locus-tag	class	description
A8C75_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8C75_RS00010	COG0592	DNA-directed DNA polymerase activity
A8C75_RS00030	COG0625	glutathione transferase activity
A8C75_RS00035	COG1846	Transcriptional regulator
A8C75_RS00040	COG0697	spore germination
A8C75_RS00045	COG0778	Nitroreductase
A8C75_RS00050	COG2986	histidine ammonia-lyase
A8C75_RS00055	COG2056	Na+-H+ antiporter family
A8C75_RS00060	COG2354	Protein conserved in bacteria
A8C75_RS00065	COG0583	DNA-binding transcription factor activity
A8C75_RS00075	COG0751	glycine-tRNA ligase activity
A8C75_RS00080	COG0752	glycyl-tRNA synthetase alpha subunit
A8C75_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8C75_RS00095	COG0569	domain protein
A8C75_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8C75_RS00110	COG0242	peptide deformylase activity
A8C75_RS00115	COG1652	LysM domain
A8C75_RS00120	COG0758	DNA mediated transformation
A8C75_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
A8C75_RS00130	COG0408	coproporphyrinogen oxidase activity
A8C75_RS00140	COG1067	ATP-dependent peptidase activity
A8C75_RS00165	COG2010	Cytochrome c
A8C75_RS00170	COG2010	Cytochrome c
A8C75_RS00185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A8C75_RS00195	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A8C75_RS00200	COG2818	Glycosylase
A8C75_RS00210	COG0534	Mate efflux family protein
A8C75_RS00215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8C75_RS00220	COG1121	(ABC) transporter
A8C75_RS00230	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A8C75_RS00255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C75_RS00265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8C75_RS00270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8C75_RS00290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8C75_RS00290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8C75_RS00305	COG2132	Multicopper oxidase
A8C75_RS00340	COG0583	DNA-binding transcription factor activity
A8C75_RS00360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8C75_RS00365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8C75_RS00370	COG0501	Belongs to the peptidase M48B family
A8C75_RS00380	COG0742	ribosomal rna small subunit methyltransferase
A8C75_RS00390	COG0552	protein localization to endoplasmic reticulum
A8C75_RS00395	COG2884	Cell division ATP-binding protein ftsE
A8C75_RS00400	COG2177	Part of the ABC transporter FtsEX involved in
A8C75_RS00410	COG2363	Small membrane protein
A8C75_RS00425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8C75_RS00430	COG0583	DNA-binding transcription factor activity
A8C75_RS00435	COG3959	Transketolase, thiamine diphosphate binding domain
A8C75_RS00440	COG3958	Transketolase
A8C75_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS00450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS00460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS00465	COG2084	Dehydrogenase
A8C75_RS00475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C75_RS00480	COG2017	converts alpha-aldose to the beta-anomer
A8C75_RS00490	COG0129	dihydroxy-acid dehydratase activity
A8C75_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS00505	COG0800	Aldolase
A8C75_RS00510	COG3386	PFAM SMP-30 Gluconolaconase
A8C75_RS00525	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C75_RS00535	COG2207	Transcriptional regulator
A8C75_RS00540	COG0745	RESPONSE REGULATOR receiver
A8C75_RS00545	COG2205	protein histidine kinase activity
A8C75_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS00570	COG0004	ammonium transporteR
A8C75_RS00610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8C75_RS00620	COG1061	Type III restriction enzyme res subunit
A8C75_RS00625	COG1132	(ABC) transporter
A8C75_RS00635	COG2814	Major facilitator Superfamily
A8C75_RS00645	COG0028	Belongs to the TPP enzyme family
A8C75_RS00655	COG0583	DNA-binding transcription factor activity
A8C75_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS00675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C75_RS00720	COG0107	imidazoleglycerol-phosphate synthase activity
A8C75_RS00725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8C75_RS00730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8C75_RS00735	COG0131	Imidazoleglycerol-phosphate dehydratase
A8C75_RS00745	COG1194	a g-specific adenine glycosylase
A8C75_RS00750	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A8C75_RS00755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8C75_RS00755	COG2111	Na H antiporter
A8C75_RS00760	COG1006	Multisubunit Na H antiporter MnhC subunit
A8C75_RS00765	COG0651	ATP synthesis coupled electron transport
A8C75_RS00770	COG1863	multisubunit Na H antiporter MnhE subunit
A8C75_RS00775	COG2212	antiporter activity
A8C75_RS00780	COG1320	monovalent cation:proton antiporter activity
A8C75_RS00790	COG2186	Transcriptional regulator
A8C75_RS00795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8C75_RS00850	COG4175	Glycine betaine
A8C75_RS00850	COG0517	IMP dehydrogenase activity
A8C75_RS00865	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS00870	COG1309	transcriptional regulator
A8C75_RS00875	COG3328	transposase activity
A8C75_RS00920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8C75_RS00925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8C75_RS00935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8C75_RS00940	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A8C75_RS00975	COG0673	inositol 2-dehydrogenase activity
A8C75_RS00985	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A8C75_RS00990	COG0175	sulfate reduction
A8C75_RS01000	COG1218	3'(2'),5'-bisphosphate nucleotidase
A8C75_RS01005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8C75_RS01015	COG1943	Transposase
A8C75_RS01040	COG0489	protein tyrosine kinase activity
A8C75_RS01055	COG4191	Histidine kinase
A8C75_RS01055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C75_RS01065	COG0640	Transcriptional regulator
A8C75_RS01070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8C75_RS01105	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A8C75_RS01115	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A8C75_RS01135	COG1917	Cupin 2, conserved barrel domain protein
A8C75_RS01140	COG5285	phytanoyl-CoA dioxygenase
A8C75_RS01145	COG0527	aspartate kinase activity
A8C75_RS01150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A8C75_RS01165	COG0129	dihydroxy-acid dehydratase activity
A8C75_RS01190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8C75_RS01190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8C75_RS01200	COG0306	phosphate transporter
A8C75_RS01205	COG1392	Phosphate transport regulator
A8C75_RS01235	COG0726	polysaccharide deacetylase
A8C75_RS01290	COG5433	transposase activity
A8C75_RS01300	COG1083	cytidylyl-transferase
A8C75_RS01305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8C75_RS01310	COG2089	acid synthase
A8C75_RS01320	COG1560	Kdo2-lipid A biosynthetic process
A8C75_RS01325	COG1132	(ABC) transporter
A8C75_RS01330	COG1519	Transferase
A8C75_RS01335	COG1965	Belongs to the frataxin family
A8C75_RS01345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8C75_RS01355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A8C75_RS01365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8C75_RS01370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8C75_RS01380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8C75_RS01380	COG2813	Specifically methylates the guanine in position
A8C75_RS01385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8C75_RS01450	COG0540	Belongs to the ATCase OTCase family
A8C75_RS01455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8C75_RS01460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8C75_RS01465	COG1678	Uncharacterized ACR, COG1678
A8C75_RS01475	COG0189	ligase activity
A8C75_RS01480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8C75_RS01485	COG3845	ABC transporter
A8C75_RS01490	COG4603	Belongs to the binding-protein-dependent transport system permease family
A8C75_RS01505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8C75_RS01510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8C75_RS01515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8C75_RS01520	COG0126	phosphoglycerate kinase activity
A8C75_RS01530	COG0246	Mannitol dehydrogenase
A8C75_RS01545	COG1175	transmembrane transport
A8C75_RS01555	COG1063	alcohol dehydrogenase
A8C75_RS01560	COG4977	sequence-specific DNA binding
A8C75_RS01560	COG1917	Cupin 2, conserved barrel domain protein
A8C75_RS01580	COG1388	LysM domain
A8C75_RS01580	COG1376	ErfK ybiS ycfS ynhG family protein
A8C75_RS01590	COG0583	DNA-binding transcription factor activity
A8C75_RS01595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8C75_RS01615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C75_RS01620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C75_RS01625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C75_RS01625	COG0649	NAD binding
A8C75_RS01635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A8C75_RS01640	COG1034	ATP synthesis coupled electron transport
A8C75_RS01645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8C75_RS01650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C75_RS01660	COG0713	ATP synthesis coupled electron transport
A8C75_RS01675	COG1007	ATP synthesis coupled electron transport
A8C75_RS01690	COG1228	amidohydrolase
A8C75_RS01700	COG0583	DNA-binding transcription factor activity
A8C75_RS01705	COG0531	amino acid
A8C75_RS01725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8C75_RS01725	COG0519	Catalyzes the synthesis of GMP from XMP
A8C75_RS01740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS01750	COG2358	TRAP transporter, solute receptor (TAXI family
A8C75_RS01765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8C75_RS01790	COG1131	(ABC) transporter
A8C75_RS01795	COG0842	Transport permease protein
A8C75_RS01800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C75_RS01800	COG3153	acetyltransferase
A8C75_RS01810	COG0513	Belongs to the DEAD box helicase family
A8C75_RS01840	COG3264	Mechanosensitive ion channel
A8C75_RS01840	COG1511	domain protein
A8C75_RS01850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C75_RS01855	COG3123	guanosine phosphorylase activity
A8C75_RS01860	COG0583	DNA-binding transcription factor activity
A8C75_RS01865	COG2814	Major facilitator Superfamily
A8C75_RS01870	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS01880	COG2010	Cytochrome c
A8C75_RS01890	COG1981	membrane
A8C75_RS01900	COG2226	methyltransferase
A8C75_RS01910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8C75_RS01915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8C75_RS01925	COG0018	arginyl-trna synthetase
A8C75_RS01930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8C75_RS01935	COG0254	rRNA binding
A8C75_RS01940	COG0281	malic enzyme
A8C75_RS01975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8C75_RS01980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8C75_RS01990	COG0067	glutamate synthase
A8C75_RS01990	COG0069	glutamate synthase activity
A8C75_RS01990	COG0070	glutamate synthase
A8C75_RS01995	COG0493	'glutamate synthase
A8C75_RS02020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8C75_RS02025	COG0288	reversible hydration of carbon dioxide
A8C75_RS02030	COG2873	o-acetylhomoserine
A8C75_RS02045	COG0488	(ABC) transporter
A8C75_RS02050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8C75_RS02055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8C75_RS02060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8C75_RS02060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8C75_RS02075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8C75_RS02085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A8C75_RS02090	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8C75_RS02095	COG0653	protein targeting
A8C75_RS02120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8C75_RS02125	COG0142	geranyltranstransferase activity
A8C75_RS02130	COG1722	exodeoxyribonuclease VII activity
A8C75_RS02135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8C75_RS02140	COG1360	Flagellar Motor Protein
A8C75_RS02180	COG2807	transmembrane transport
A8C75_RS02185	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C75_RS02195	COG1215	transferase activity, transferring glycosyl groups
A8C75_RS02205	COG2186	Transcriptional regulator
A8C75_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS02215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C75_RS02230	COG1917	Cupin 2, conserved barrel domain protein
A8C75_RS02235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C75_RS02240	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS02250	COG1653	transport
A8C75_RS02255	COG0395	ABC-type sugar transport system, permease component
A8C75_RS02260	COG4209	transmembrane transport
A8C75_RS02265	COG3842	ATPase activity
A8C75_RS02275	COG2188	Transcriptional regulator
A8C75_RS02280	COG3314	Sporulation integral membrane protein YlbJ
A8C75_RS02290	COG1228	amidohydrolase
A8C75_RS02295	COG0010	Belongs to the arginase family
A8C75_RS02300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A8C75_RS02305	COG2902	Dehydrogenase
A8C75_RS02335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8C75_RS02340	COG0733	neurotransmitter:sodium symporter activity
A8C75_RS02345	COG2867	negative regulation of translational initiation
A8C75_RS02350	COG2914	Belongs to the UPF0125 (RnfH) family
A8C75_RS02355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8C75_RS02360	COG0735	belongs to the Fur family
A8C75_RS02365	COG0497	DNA recombination
A8C75_RS02370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8C75_RS02375	COG0443	Heat shock 70 kDa protein
A8C75_RS02380	COG0484	heat shock protein binding
A8C75_RS02390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8C75_RS02410	COG2095	MarC family integral membrane protein
A8C75_RS02420	COG5016	pyruvate
A8C75_RS02420	COG0511	ligase activity, forming carbon-carbon bonds
A8C75_RS02425	COG0439	Biotin carboxylase
A8C75_RS02430	COG0583	DNA-binding transcription factor activity
A8C75_RS02435	COG2816	NAD+ diphosphatase activity
A8C75_RS02440	COG0494	nUDIX hydrolase
A8C75_RS02450	COG0011	TIGRFAM Protein of
A8C75_RS02455	COG4536	flavin adenine dinucleotide binding
A8C75_RS02460	COG4137	Cytochrome C assembly protein
A8C75_RS02465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8C75_RS02470	COG0228	four-way junction DNA binding
A8C75_RS02475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8C75_RS02485	COG0335	large ribosomal subunit rRNA binding
A8C75_RS02495	COG4974	Belongs to the 'phage' integrase family
A8C75_RS02500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8C75_RS02515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A8C75_RS02520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8C75_RS02535	COG2200	EAL domain
A8C75_RS02540	COG0494	nUDIX hydrolase
A8C75_RS02545	COG3151	Protein conserved in bacteria
A8C75_RS02550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8C75_RS02555	COG3150	esterase
A8C75_RS02575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8C75_RS02580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8C75_RS02590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8C75_RS02595	COG0768	penicillin binding
A8C75_RS02600	COG0772	Belongs to the SEDS family
A8C75_RS02605	COG2951	lytic endotransglycosylase activity
A8C75_RS02610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8C75_RS02615	COG1686	Belongs to the peptidase S11 family
A8C75_RS02625	COG2921	Belongs to the UPF0250 family
A8C75_RS02630	COG0321	lipoyl(octanoyl) transferase activity
A8C75_RS02635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8C75_RS02645	COG2423	ornithine cyclodeaminase activity
A8C75_RS02650	COG1757	Na H antiporter
A8C75_RS02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS02655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A8C75_RS02680	COG1466	dna polymerase III delta subunit
A8C75_RS02690	COG0495	leucyl-tRNA aminoacylation
A8C75_RS02705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8C75_RS02720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A8C75_RS02725	COG4535	Mg2 and Co2 transporter CorC
A8C75_RS02730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8C75_RS02735	COG1702	phosphate starvation-inducible protein PhoH
A8C75_RS02740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8C75_RS02755	COG1509	lysine 2,3-aminomutase activity
A8C75_RS02760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8C75_RS02765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A8C75_RS02770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A8C75_RS02775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8C75_RS02795	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A8C75_RS02800	COG4191	Histidine kinase
A8C75_RS02810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8C75_RS02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C75_RS02820	COG1309	transcriptional regulator
A8C75_RS02830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8C75_RS02835	COG0084	hydrolase, TatD family'
A8C75_RS02885	COG0024	Methionine aminopeptidase
A8C75_RS02890	COG0052	Belongs to the universal ribosomal protein uS2 family
A8C75_RS02895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8C75_RS02900	COG0528	UMP kinase activity
A8C75_RS02905	COG0233	cytoplasmic translational termination
A8C75_RS02940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8C75_RS02945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C75_RS02950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C75_RS02955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8C75_RS02965	COG0825	malonyl-CoA metabolic process
A8C75_RS02970	COG0037	tRNA processing
A8C75_RS02975	COG0504	CTP synthase activity
A8C75_RS02985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8C75_RS02990	COG0585	pseudouridine synthase activity
A8C75_RS02995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A8C75_RS03000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8C75_RS03020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A8C75_RS03025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8C75_RS03040	COG1546	Belongs to the CinA family
A8C75_RS03045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8C75_RS03060	COG1522	sequence-specific DNA binding
A8C75_RS03070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8C75_RS03120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS03125	COG0583	DNA-binding transcription factor activity
A8C75_RS03130	COG3739	integral membrane protein
A8C75_RS03140	COG0217	transcriptional regulatory protein
A8C75_RS03150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C75_RS03155	COG0628	permease
A8C75_RS03170	COG2823	Periplasmic or secreted lipoprotein
A8C75_RS03175	COG2204	response regulator
A8C75_RS03180	COG3852	Histidine kinase
A8C75_RS03190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8C75_RS03195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS03215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8C75_RS03225	COG2030	dehydratase
A8C75_RS03230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8C75_RS03235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8C75_RS03240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8C75_RS03265	COG0667	Aldo Keto reductase
A8C75_RS03290	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8C75_RS03295	COG1063	alcohol dehydrogenase
A8C75_RS03300	COG1760	l-serine dehydratase
A8C75_RS03305	COG0583	DNA-binding transcription factor activity
A8C75_RS03325	COG1902	pentaerythritol trinitrate reductase activity
A8C75_RS03325	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8C75_RS03330	COG0247	lactate metabolic process
A8C75_RS03330	COG2181	nitrate reductase activity
A8C75_RS03335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8C75_RS03365	COG2409	Drug exporters of the RND superfamily
A8C75_RS03370	COG2072	flavoprotein involved in K transport
A8C75_RS03375	COG3321	synthase
A8C75_RS03375	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8C75_RS03375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C75_RS03375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8C75_RS03385	COG1104	cysteine desulfurase activity
A8C75_RS03405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS03425	COG4638	Rieske (2fe-2S)
A8C75_RS03430	COG1017	nitric oxide dioxygenase activity
A8C75_RS03430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C75_RS03445	COG2137	regulation of response to DNA damage stimulus
A8C75_RS03450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8C75_RS03455	COG0527	aspartate kinase activity
A8C75_RS03460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A8C75_RS03485	COG0301	tRNA thio-modification
A8C75_RS03485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C75_RS03490	COG3630	sodium ion export across plasma membrane
A8C75_RS03495	COG5016	pyruvate
A8C75_RS03495	COG0511	ligase activity, forming carbon-carbon bonds
A8C75_RS03500	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A8C75_RS03505	COG0583	DNA-binding transcription factor activity
A8C75_RS03520	COG0439	Biotin carboxylase
A8C75_RS03530	COG1984	allophanate hydrolase subunit 2
A8C75_RS03540	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8C75_RS03545	COG0745	RESPONSE REGULATOR receiver
A8C75_RS03550	COG1309	transcriptional regulator
A8C75_RS03565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8C75_RS03570	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8C75_RS03575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8C75_RS03585	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A8C75_RS03585	COG0778	Nitroreductase
A8C75_RS03605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8C75_RS03610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8C75_RS03630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8C75_RS03635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8C75_RS03640	COG1845	cytochrome c oxidase, subunit III
A8C75_RS03645	COG1845	cytochrome c oxidase, subunit III
A8C75_RS03660	COG3238	Protein conserved in bacteria
A8C75_RS03670	COG1953	Uracil, thiamine, allantoin
A8C75_RS03725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS03730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS03735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8C75_RS03755	COG0183	Belongs to the thiolase family
A8C75_RS03760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8C75_RS03765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8C75_RS03770	COG3246	L-lysine catabolic process to acetate
A8C75_RS03775	COG3485	protocatechuate 3,4-dioxygenase
A8C75_RS03780	COG3485	protocatechuate 3,4-dioxygenase
A8C75_RS03785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8C75_RS03790	COG0583	DNA-binding transcription factor activity
A8C75_RS03810	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS03815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C75_RS03820	COG0583	DNA-binding transcription factor activity
A8C75_RS03825	COG4638	Rieske (2fe-2S)
A8C75_RS03835	COG4176	ABC-type proline glycine betaine transport system permease component
A8C75_RS03840	COG2113	Glycine betaine
A8C75_RS03850	COG3706	GGDEF domain
A8C75_RS03870	COG0673	inositol 2-dehydrogenase activity
A8C75_RS03890	COG1802	Transcriptional regulator
A8C75_RS03895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8C75_RS03900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A8C75_RS03910	COG1473	amidohydrolase
A8C75_RS03955	COG3128	pkhd-type hydroxylase
A8C75_RS03960	COG4774	siderophore transport
A8C75_RS03970	COG0848	biopolymer transport protein
A8C75_RS03975	COG0848	biopolymer transport protein
A8C75_RS03990	COG0745	RESPONSE REGULATOR receiver
A8C75_RS04015	COG1815	bacterial-type flagellum-dependent cell motility
A8C75_RS04020	COG1558	bacterial-type flagellum-dependent cell motility
A8C75_RS04030	COG1749	Flagellar hook protein flgE
A8C75_RS04035	COG4786	Flagellar basal body rod
A8C75_RS04050	COG1706	bacterial-type flagellum-dependent cell motility
A8C75_RS04065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8C75_RS04070	COG1943	Transposase
A8C75_RS04090	COG1334	flagellar protein FlaG
A8C75_RS04115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8C75_RS04135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C75_RS04150	COG1677	Flagellar hook-basal body complex protein FliE
A8C75_RS04180	COG3144	bacterial-type flagellum assembly
A8C75_RS04210	COG1987	bacterial-type flagellum assembly
A8C75_RS04215	COG1684	flagellar biosynthetic protein fliR
A8C75_RS04225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8C75_RS04245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8C75_RS04250	COG1360	Flagellar Motor Protein
A8C75_RS04260	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8C75_RS04270	COG4133	protoheme IX ABC transporter activity
A8C75_RS04290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A8C75_RS04295	COG1138	Cytochrome C-type biogenesis protein
A8C75_RS04315	COG3115	cell septum assembly
A8C75_RS04315	COG3115	cell septum assembly
A8C75_RS04320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8C75_RS04340	COG0517	IMP dehydrogenase activity
A8C75_RS04340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8C75_RS04340	COG0617	tRNA 3'-terminal CCA addition
A8C75_RS04345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS04345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A8C75_RS04350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8C75_RS04365	COG1091	dTDP-4-dehydrorhamnose reductase activity
A8C75_RS04370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A8C75_RS04385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A8C75_RS04395	COG2244	polysaccharide biosynthetic process
A8C75_RS04405	COG0438	transferase activity, transferring glycosyl groups
A8C75_RS04410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8C75_RS04420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8C75_RS04425	COG0653	protein targeting
A8C75_RS04435	COG1793	dna ligase
A8C75_RS04455	COG0358	DNA primase activity
A8C75_RS04470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8C75_RS04475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8C75_RS04490	COG0617	tRNA 3'-terminal CCA addition
A8C75_RS04495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C75_RS04500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8C75_RS04505	COG2967	ApaG domain
A8C75_RS04510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8C75_RS04525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8C75_RS04530	COG3178	'Phosphotransferase
A8C75_RS04535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8C75_RS04540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8C75_RS04550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8C75_RS04555	COG0546	phosphoglycolate phosphatase activity
A8C75_RS04585	COG4336	lyase activity
A8C75_RS04605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8C75_RS04610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8C75_RS04615	COG1984	allophanate hydrolase subunit 2
A8C75_RS04620	COG2902	Dehydrogenase
A8C75_RS04665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8C75_RS04670	COG0134	indole-3-glycerol-phosphate synthase activity
A8C75_RS04675	COG1765	OsmC-like protein
A8C75_RS04680	COG0360	Binds together with S18 to 16S ribosomal RNA
A8C75_RS04685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8C75_RS04695	COG0359	binds to the 23S rRNA
A8C75_RS04700	COG0305	Participates in initiation and elongation during chromosome replication
A8C75_RS04715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C75_RS04720	COG1720	tRNA m6t6A37 methyltransferase activity
A8C75_RS04735	COG1040	competence protein
A8C75_RS04740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8C75_RS04745	COG0156	8-amino-7-oxononanoate synthase activity
A8C75_RS04750	COG2267	carboxylic ester hydrolase activity
A8C75_RS04755	COG2226	methyltransferase
A8C75_RS04755	COG1073	alpha beta
A8C75_RS04760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8C75_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS04805	COG4638	Rieske (2fe-2S)
A8C75_RS04810	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A8C75_RS04815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C75_RS04815	COG0543	2 iron, 2 sulfur cluster binding
A8C75_RS04820	COG1846	Transcriptional regulator
A8C75_RS04840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS04845	COG1304	FMN binding
A8C75_RS04860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS04870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS04870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS04875	COG0583	DNA-binding transcription factor activity
A8C75_RS04880	COG3483	tryptophan 2,3-dioxygenase activity
A8C75_RS04885	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8C75_RS04895	COG0733	neurotransmitter:sodium symporter activity
A8C75_RS04900	COG0596	Alpha beta hydrolase
A8C75_RS04905	COG0545	Peptidyl-prolyl cis-trans isomerase
A8C75_RS04915	COG1570	exodeoxyribonuclease VII activity
A8C75_RS04935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A8C75_RS04950	COG2350	Protein conserved in bacteria
A8C75_RS04955	COG2917	probably involved in intracellular septation
A8C75_RS04960	COG0613	PHP domain protein
A8C75_RS04965	COG0009	L-threonylcarbamoyladenylate synthase
A8C75_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS04990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8C75_RS05000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8C75_RS05010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8C75_RS05015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8C75_RS05020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8C75_RS05030	COG0776	regulation of translation
A8C75_RS05040	COG0284	orotidine-5'-phosphate decarboxylase activity
A8C75_RS05060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS05070	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8C75_RS05075	COG2186	Transcriptional regulator
A8C75_RS05085	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C75_RS05100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8C75_RS05105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8C75_RS05115	COG2308	Evidence 4 Homologs of previously reported genes of
A8C75_RS05115	COG2307	Protein conserved in bacteria
A8C75_RS05130	COG2308	Evidence 4 Homologs of previously reported genes of
A8C75_RS05150	COG0433	COG0433 Predicted ATPase
A8C75_RS05155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A8C75_RS05160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8C75_RS05165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8C75_RS05170	COG0723	plastoquinol--plastocyanin reductase activity
A8C75_RS05175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8C75_RS05180	COG2857	Cytochrome c1
A8C75_RS05185	COG0625	glutathione transferase activity
A8C75_RS05190	COG2969	positive regulation of protein catabolic process
A8C75_RS05195	COG2823	Periplasmic or secreted lipoprotein
A8C75_RS05200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A8C75_RS05205	COG0792	nuclease activity
A8C75_RS05230	COG0275	rRNA processing
A8C75_RS05235	COG3116	cell division
A8C75_RS05245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8C75_RS05250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8C75_RS05255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8C75_RS05265	COG0772	Belongs to the SEDS family
A8C75_RS05270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8C75_RS05275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8C75_RS05295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8C75_RS05300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A8C75_RS05305	COG0653	protein targeting
A8C75_RS05310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8C75_RS05315	COG0494	nUDIX hydrolase
A8C75_RS05320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A8C75_RS05325	COG0237	dephospho-CoA kinase activity
A8C75_RS05330	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8C75_RS05360	COG3023	N-Acetylmuramoyl-L-alanine amidase
A8C75_RS05370	COG3842	ATPase activity
A8C75_RS05375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A8C75_RS05380	COG1840	ABC-type Fe3 transport system, periplasmic component
A8C75_RS05385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8C75_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS05400	COG3012	SEC-C Motif Domain Protein
A8C75_RS05405	COG2925	Exonuclease
A8C75_RS05430	COG0697	spore germination
A8C75_RS05450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8C75_RS05465	COG3344	reverse transcriptase
A8C75_RS05480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8C75_RS05490	COG5265	(ABC) transporter
A8C75_RS05520	COG0625	glutathione transferase activity
A8C75_RS05530	COG3132	Protein of unknown function, DUF480
A8C75_RS05555	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A8C75_RS05560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8C75_RS05575	COG1968	undecaprenyl-diphosphatase activity
A8C75_RS05585	COG0742	ribosomal rna small subunit methyltransferase
A8C75_RS05590	COG2937	Belongs to the GPAT DAPAT family
A8C75_RS05595	COG2900	Belongs to the SlyX family
A8C75_RS05610	COG1801	Protein of unknown function DUF72
A8C75_RS05620	COG4584	PFAM Integrase catalytic
A8C75_RS05625	COG1484	DNA-dependent DNA replication
A8C75_RS05630	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A8C75_RS05645	COG2207	Transcriptional regulator
A8C75_RS05660	COG0746	molybdenum cofactor guanylyltransferase activity
A8C75_RS05665	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS05680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8C75_RS05685	COG3265	gluconokinase activity
A8C75_RS05690	COG1609	Transcriptional regulator
A8C75_RS05695	COG2824	Alkylphosphonate utilization operon protein PhnA
A8C75_RS05705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8C75_RS05710	COG0154	amidase activity
A8C75_RS05715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8C75_RS05720	COG1077	Cell shape determining protein MreB Mrl
A8C75_RS05725	COG1792	Involved in formation and maintenance of cell shape
A8C75_RS05730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A8C75_RS05735	COG0424	maF-like protein
A8C75_RS05740	COG1530	ribonuclease E activity
A8C75_RS05750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C75_RS05755	COG3028	Belongs to the UPF0307 family
A8C75_RS05760	COG2239	Acts as a magnesium transporter
A8C75_RS05765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8C75_RS05770	COG1660	Displays ATPase and GTPase activities
A8C75_RS05785	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8C75_RS05790	COG1137	ATPase activity
A8C75_RS05795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A8C75_RS05805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A8C75_RS05815	COG1127	ABC transporter
A8C75_RS05820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8C75_RS05825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A8C75_RS05840	COG5007	Belongs to the BolA IbaG family
A8C75_RS05845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8C75_RS05850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8C75_RS05855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8C75_RS05860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C75_RS05875	COG1802	Transcriptional regulator
A8C75_RS05880	COG0604	alcohol dehydrogenase
A8C75_RS05885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C75_RS05895	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A8C75_RS05910	COG2096	Adenosyltransferase
A8C75_RS05920	COG1666	GTP binding
A8C75_RS05930	COG2211	Major facilitator Superfamily
A8C75_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS05940	COG3030	protein affecting phage T7 exclusion by the F plasmid
A8C75_RS05945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8C75_RS05950	COG0459	protein refolding
A8C75_RS05955	COG0747	negative chemotaxis
A8C75_RS05960	COG0601	transmembrane transport
A8C75_RS05965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C75_RS05970	COG0444	Belongs to the ABC transporter superfamily
A8C75_RS05975	COG4608	Belongs to the ABC transporter superfamily
A8C75_RS05980	COG2866	Carboxypeptidase
A8C75_RS05985	COG0583	DNA-binding transcription factor activity
A8C75_RS05990	COG0006	proline dipeptidase activity
A8C75_RS05995	COG0514	ATP-dependent DNA helicase (RecQ)
A8C75_RS06010	COG0318	PFAM AMP-dependent synthetase and ligase
A8C75_RS06015	COG0733	neurotransmitter:sodium symporter activity
A8C75_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS06045	COG1473	amidohydrolase
A8C75_RS06060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8C75_RS06075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8C75_RS06075	COG0617	tRNA 3'-terminal CCA addition
A8C75_RS06075	COG0517	IMP dehydrogenase activity
A8C75_RS06100	COG3098	single-species biofilm formation
A8C75_RS06105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A8C75_RS06110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8C75_RS06115	COG0583	DNA-binding transcription factor activity
A8C75_RS06120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8C75_RS06125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8C75_RS06130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A8C75_RS06135	COG0450	alkyl hydroperoxide reductase
A8C75_RS06140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8C75_RS06150	COG0137	argininosuccinate synthase activity
A8C75_RS06170	COG1104	cysteine desulfurase activity
A8C75_RS06185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8C75_RS06210	COG2274	protein secretion by the type I secretion system
A8C75_RS06215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C75_RS06225	COG1538	Outer membrane efflux protein
A8C75_RS06235	COG1304	FMN binding
A8C75_RS06240	COG3425	synthase
A8C75_RS06245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8C75_RS06260	COG0417	DNA replication proofreading
A8C75_RS06265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8C75_RS06270	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A8C75_RS06285	COG1017	nitric oxide dioxygenase activity
A8C75_RS06285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C75_RS06290	COG3706	GGDEF domain
A8C75_RS06290	COG4251	negative regulation of phosphorylation
A8C75_RS06290	COG2203	Gaf domain
A8C75_RS06290	COG5001	Diguanylate cyclase
A8C75_RS06295	COG1309	transcriptional regulator
A8C75_RS06305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8C75_RS06330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8C75_RS06335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8C75_RS06340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C75_RS06345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8C75_RS06355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8C75_RS06360	COG4660	Part of a membrane complex involved in electron transport
A8C75_RS06365	COG4659	FMN binding
A8C75_RS06370	COG4658	electron transport chain
A8C75_RS06380	COG2878	Part of a membrane complex involved in electron transport
A8C75_RS06385	COG4657	Part of a membrane complex involved in electron transport
A8C75_RS06395	COG0175	sulfate reduction
A8C75_RS06400	COG0730	response to heat
A8C75_RS06405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C75_RS06415	COG0175	sulfate reduction
A8C75_RS06420	COG1648	precorrin-2 dehydrogenase activity
A8C75_RS06420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8C75_RS06430	COG0745	RESPONSE REGULATOR receiver
A8C75_RS06440	COG3706	GGDEF domain
A8C75_RS06445	COG1177	transmembrane transport
A8C75_RS06450	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8C75_RS06455	COG3842	ATPase activity
A8C75_RS06460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8C75_RS06485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C75_RS06490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS06505	COG1609	Transcriptional regulator
A8C75_RS06520	COG0789	Transcriptional regulator
A8C75_RS06525	COG0484	heat shock protein binding
A8C75_RS06530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C75_RS06545	COG3784	Protein of unknown function (DUF1318)
A8C75_RS06560	COG0583	DNA-binding transcription factor activity
A8C75_RS06570	COG0247	lactate metabolic process
A8C75_RS06585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8C75_RS06610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8C75_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS06655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS06655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS06660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS06665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS06675	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C75_RS06680	COG3246	L-lysine catabolic process to acetate
A8C75_RS06725	COG4245	von Willebrand factor, type A
A8C75_RS06780	COG1518	maintenance of DNA repeat elements
A8C75_RS06835	COG3293	Transposase
A8C75_RS06840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C75_RS06855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS06890	COG2226	methyltransferase
A8C75_RS06895	COG0318	PFAM AMP-dependent synthetase and ligase
A8C75_RS06905	COG0789	Transcriptional regulator
A8C75_RS06910	COG0183	Belongs to the thiolase family
A8C75_RS06915	COG0346	lactoylglutathione lyase activity
A8C75_RS06930	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS06935	COG1024	Enoyl-CoA hydratase
A8C75_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS06975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A8C75_RS06980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8C75_RS06985	COG1349	DNA-binding transcription factor activity
A8C75_RS06990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8C75_RS06995	COG3284	Transcriptional regulator
A8C75_RS07000	COG2801	Transposase and inactivated derivatives
A8C75_RS07005	COG3344	reverse transcriptase
A8C75_RS07020	COG3842	ATPase activity
A8C75_RS07025	COG3842	ATPase activity
A8C75_RS07035	COG0395	ABC-type sugar transport system, permease component
A8C75_RS07050	COG1454	alcohol dehydrogenase
A8C75_RS07060	COG2814	Major facilitator Superfamily
A8C75_RS07070	COG2205	protein histidine kinase activity
A8C75_RS07085	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS07105	COG1252	NADH dehydrogenase
A8C75_RS07120	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A8C75_RS07125	COG1074	ATP-dependent DNA helicase activity
A8C75_RS07130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8C75_RS07140	COG1959	2 iron, 2 sulfur cluster binding
A8C75_RS07145	COG4991	sh3 domain protein
A8C75_RS07150	COG0668	transmembrane transport
A8C75_RS07165	COG0579	oxidoreductase
A8C75_RS07170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8C75_RS07175	COG1611	Belongs to the LOG family
A8C75_RS07180	COG0739	heme binding
A8C75_RS07190	COG0121	glutamine amidotransferase
A8C75_RS07195	COG1643	Atp-dependent helicase
A8C75_RS07220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8C75_RS07225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8C75_RS07235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A8C75_RS07240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A8C75_RS07250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C75_RS07270	COG0501	Belongs to the peptidase M48B family
A8C75_RS07275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8C75_RS07275	COG0116	Belongs to the methyltransferase superfamily
A8C75_RS07290	COG0406	alpha-ribazole phosphatase activity
A8C75_RS07295	COG0438	transferase activity, transferring glycosyl groups
A8C75_RS07320	COG0668	transmembrane transport
A8C75_RS07325	COG0436	Aminotransferase
A8C75_RS07400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8C75_RS07410	COG3139	Protein of unknown function (DUF1315)
A8C75_RS07420	COG0308	aminopeptidase N
A8C75_RS07435	COG0546	phosphoglycolate phosphatase activity
A8C75_RS07445	COG0307	riboflavin synthase, alpha
A8C75_RS07450	COG1090	epimerase
A8C75_RS07470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8C75_RS07470	COG0116	Belongs to the methyltransferase superfamily
A8C75_RS07475	COG0004	ammonium transporteR
A8C75_RS07480	COG0039	L-malate dehydrogenase activity
A8C75_RS07495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A8C75_RS07500	COG1053	succinate dehydrogenase
A8C75_RS07505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8C75_RS07555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A8C75_RS07580	COG2205	protein histidine kinase activity
A8C75_RS07580	COG2198	Histidine kinase
A8C75_RS07580	COG0784	Response regulator, receiver
A8C75_RS07585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS07595	COG0384	phenazine biosynthesis protein PhzF
A8C75_RS07610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8C75_RS07615	COG1054	Belongs to the UPF0176 family
A8C75_RS07650	COG3695	enzyme binding
A8C75_RS07660	COG3706	GGDEF domain
A8C75_RS07665	COG0589	response to stress
A8C75_RS07670	COG0708	Exodeoxyribonuclease III
A8C75_RS07680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A8C75_RS07685	COG4149	molybdate abc transporter
A8C75_RS07690	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8C75_RS07695	COG3585	molybdate ion transport
A8C75_RS07695	COG2005	Transcriptional regulator
A8C75_RS07700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8C75_RS07710	COG0583	DNA-binding transcription factor activity
A8C75_RS07725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8C75_RS07745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8C75_RS07755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8C75_RS07765	COG0632	four-way junction helicase activity
A8C75_RS07770	COG2255	four-way junction helicase activity
A8C75_RS07790	COG0823	Involved in the tonB-independent uptake of proteins
A8C75_RS07795	COG2885	chlorophyll binding
A8C75_RS07805	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A8C75_RS07815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8C75_RS07820	COG4783	chaperone-mediated protein folding
A8C75_RS07825	COG0425	Belongs to the sulfur carrier protein TusA family
A8C75_RS07835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8C75_RS07840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C75_RS07850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C75_RS07855	COG0564	pseudouridine synthase activity
A8C75_RS07860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8C75_RS07865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A8C75_RS07870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8C75_RS07875	COG3108	Peptidase M15
A8C75_RS07880	COG4651	solute:proton antiporter activity
A8C75_RS07880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8C75_RS07885	COG0534	Mate efflux family protein
A8C75_RS07890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8C75_RS07890	COG0316	Belongs to the HesB IscA family
A8C75_RS07895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8C75_RS07905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8C75_RS07910	COG4172	Belongs to the ABC transporter superfamily
A8C75_RS07915	COG4239	(ABC) transporter, permease
A8C75_RS07920	COG4174	ABC transporter (Permease)
A8C75_RS07925	COG4166	transmembrane transport
A8C75_RS07930	COG0741	lytic transglycosylase activity
A8C75_RS07930	COG1388	LysM domain
A8C75_RS07940	COG2226	methyltransferase
A8C75_RS07945	COG0328	RNA-DNA hybrid ribonuclease activity
A8C75_RS07950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8C75_RS07955	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8C75_RS07960	COG2816	NAD+ diphosphatase activity
A8C75_RS07970	COG0616	signal peptide processing
A8C75_RS07980	COG1376	ErfK ybiS ycfS ynhG family protein
A8C75_RS07985	COG1472	Belongs to the glycosyl hydrolase 3 family
A8C75_RS07990	COG0668	transmembrane transport
A8C75_RS07995	COG5002	protein histidine kinase activity
A8C75_RS08005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8C75_RS08020	COG1805	sodium ion transport
A8C75_RS08035	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A8C75_RS08040	COG2871	sodium ion transport
A8C75_RS08045	COG1477	protein flavinylation
A8C75_RS08050	COG2991	Protein conserved in bacteria
A8C75_RS08055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8C75_RS08070	COG4628	conserved protein (DUF2132)
A8C75_RS08095	COG4591	ABC-type transport system involved in lipoprotein release permease component
A8C75_RS08100	COG1136	(ABC) transporter
A8C75_RS08110	COG0658	competence protein
A8C75_RS08110	COG2333	competence protein COMEC
A8C75_RS08115	COG0811	peptide transport
A8C75_RS08120	COG0848	biopolymer transport protein
A8C75_RS08125	COG1663	tetraacyldisaccharide 4'-kinase activity
A8C75_RS08130	COG2835	tetraacyldisaccharide 4'-kinase activity
A8C75_RS08135	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A8C75_RS08145	COG1566	PFAM secretion protein HlyD family protein
A8C75_RS08155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8C75_RS08160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8C75_RS08165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8C75_RS08175	COG3100	YcgL domain-containing protein
A8C75_RS08180	COG2983	Belongs to the UPF0260 family
A8C75_RS08210	COG1362	aminopeptidase activity
A8C75_RS08230	COG1216	Glycosyl transferase, family 2
A8C75_RS08270	COG0438	transferase activity, transferring glycosyl groups
A8C75_RS08275	COG0438	transferase activity, transferring glycosyl groups
A8C75_RS08280	COG0367	asparagine synthase
A8C75_RS08305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8C75_RS08320	COG0463	Glycosyl transferase, family 2
A8C75_RS08330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8C75_RS08335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8C75_RS08340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8C75_RS08370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C75_RS08375	COG1819	glycosyl
A8C75_RS08405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C75_RS08415	COG2204	response regulator
A8C75_RS08440	COG3267	Type II secretory pathway component ExeA
A8C75_RS08440	COG3409	Peptidoglycan-binding domain 1 protein
A8C75_RS08450	COG0489	protein tyrosine kinase activity
A8C75_RS08465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8C75_RS08475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8C75_RS08485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8C75_RS08530	COG0463	Glycosyl transferase, family 2
A8C75_RS08570	COG1944	ATP diphosphatase activity
A8C75_RS08590	COG1196	nuclear chromosome segregation
A8C75_RS08610	COG0271	Belongs to the BolA IbaG family
A8C75_RS08620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8C75_RS08625	COG1132	(ABC) transporter
A8C75_RS08630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C75_RS08640	COG3012	SEC-C Motif Domain Protein
A8C75_RS08640	COG3318	Belongs to the UPF0149 family
A8C75_RS08645	COG0514	ATP-dependent DNA helicase (RecQ)
A8C75_RS08650	COG0037	tRNA processing
A8C75_RS08665	COG3101	peptidyl-lysine hydroxylation
A8C75_RS08685	COG0523	cobalamin synthesis protein
A8C75_RS08700	COG0243	molybdopterin cofactor binding
A8C75_RS08705	COG2146	nitrite reductase [NAD(P)H] activity
A8C75_RS08710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C75_RS08715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C75_RS08720	COG2815	serine threonine protein kinase
A8C75_RS08720	COG0515	serine threonine protein kinase
A8C75_RS08725	COG2223	nitrite transmembrane transporter activity
A8C75_RS08730	COG1116	anion transmembrane transporter activity
A8C75_RS08740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C75_RS08745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C75_RS08750	COG0745	RESPONSE REGULATOR receiver
A8C75_RS08755	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A8C75_RS08755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8C75_RS08760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C75_RS08785	COG3228	Belongs to the MtfA family
A8C75_RS08800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8C75_RS08805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8C75_RS08815	COG0628	permease
A8C75_RS08830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8C75_RS08870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C75_RS08885	COG0582	viral genome integration into host DNA
A8C75_RS08955	COG0420	3'-5' exonuclease activity
A8C75_RS08960	COG0419	ATPase involved in DNA repair
A8C75_RS08980	COG1074	ATP-dependent DNA helicase activity
A8C75_RS08985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C75_RS09035	COG2003	Belongs to the UPF0758 family
A8C75_RS09055	COG0714	Associated with various cellular activities
A8C75_RS09125	COG0583	DNA-binding transcription factor activity
A8C75_RS09135	COG2175	clavaminate synthase activity
A8C75_RS09145	COG0560	Phosphoserine phosphatase
A8C75_RS09155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C75_RS09175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8C75_RS09180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8C75_RS09185	COG1530	ribonuclease E activity
A8C75_RS09215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8C75_RS09225	COG1802	Transcriptional regulator
A8C75_RS09230	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8C75_RS09235	COG0372	Belongs to the citrate synthase family
A8C75_RS09240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8C75_RS09250	COG2079	MmgE PrpD family protein
A8C75_RS09255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8C75_RS09265	COG0583	DNA-binding transcription factor activity
A8C75_RS09270	COG0277	FAD linked oxidase domain protein
A8C75_RS09270	COG0247	lactate metabolic process
A8C75_RS09280	COG0583	DNA-binding transcription factor activity
A8C75_RS09290	COG1671	Belongs to the UPF0178 family
A8C75_RS09300	COG0492	ferredoxin-NADP+ reductase activity
A8C75_RS09305	COG1959	2 iron, 2 sulfur cluster binding
A8C75_RS09310	COG0546	phosphoglycolate phosphatase activity
A8C75_RS09325	COG1399	metal-binding, possibly nucleic acid-binding protein
A8C75_RS09330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8C75_RS09335	COG0416	fatty acid biosynthetic process
A8C75_RS09350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C75_RS09355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C75_RS09360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8C75_RS09365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8C75_RS09370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8C75_RS09385	COG0084	hydrolase, TatD family'
A8C75_RS09390	COG0039	L-malate dehydrogenase activity
A8C75_RS09395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8C75_RS09400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C75_RS09400	COG3453	Protein conserved in bacteria
A8C75_RS09410	COG0432	Pfam Uncharacterised protein family UPF0047
A8C75_RS09415	COG2084	Dehydrogenase
A8C75_RS09420	COG2920	part of a sulfur-relay system
A8C75_RS09435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A8C75_RS09440	COG0670	Belongs to the BI1 family
A8C75_RS09450	COG0564	pseudouridine synthase activity
A8C75_RS09455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8C75_RS09460	COG4172	Belongs to the ABC transporter superfamily
A8C75_RS09470	COG0601	transmembrane transport
A8C75_RS09475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C75_RS09480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C75_RS09485	COG2084	Dehydrogenase
A8C75_RS09490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A8C75_RS09495	COG4232	protein-disulfide reductase activity
A8C75_RS09505	COG2030	dehydratase
A8C75_RS09510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A8C75_RS09515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8C75_RS09530	COG2081	HI0933 family
A8C75_RS09535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS09545	COG4095	Psort location CytoplasmicMembrane, score
A8C75_RS09555	COG0330	HflC and HflK could
A8C75_RS09590	COG5487	UPF0391 membrane protein
A8C75_RS09595	COG2823	Periplasmic or secreted lipoprotein
A8C75_RS09615	COG3237	CsbD-like
A8C75_RS09620	COG2197	response regulator
A8C75_RS09655	COG1953	Uracil, thiamine, allantoin
A8C75_RS09660	COG1953	Uracil, thiamine, allantoin
A8C75_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS09700	COG3383	formate dehydrogenase (NAD+) activity
A8C75_RS09725	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS09740	COG2943	transferase activity, transferring hexosyl groups
A8C75_RS09745	COG0673	inositol 2-dehydrogenase activity
A8C75_RS09750	COG0673	inositol 2-dehydrogenase activity
A8C75_RS09770	COG1858	cytochrome C peroxidase
A8C75_RS09780	COG0673	inositol 2-dehydrogenase activity
A8C75_RS09785	COG4670	ketone body catabolic process
A8C75_RS09790	COG1024	Enoyl-CoA hydratase
A8C75_RS09795	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS09805	COG1175	transmembrane transport
A8C75_RS09810	COG0395	ABC-type sugar transport system, permease component
A8C75_RS09815	COG3842	ATPase activity
A8C75_RS09825	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS09835	COG1609	Transcriptional regulator
A8C75_RS09855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS09925	COG2814	Major facilitator Superfamily
A8C75_RS09930	COG0583	DNA-binding transcription factor activity
A8C75_RS09935	COG0778	Nitroreductase
A8C75_RS09945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8C75_RS09950	COG1301	dicarboxylic acid transport
A8C75_RS09980	COG2375	cellular response to nickel ion
A8C75_RS09985	COG0747	negative chemotaxis
A8C75_RS09990	COG0601	transmembrane transport
A8C75_RS09995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C75_RS10015	COG0583	DNA-binding transcription factor activity
A8C75_RS10025	COG0318	PFAM AMP-dependent synthetase and ligase
A8C75_RS10025	COG0204	Acyl-transferase
A8C75_RS10045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C75_RS10050	COG2151	metal-sulfur cluster biosynthetic enzyme
A8C75_RS10055	COG3396	Phenylacetate-CoA oxygenase
A8C75_RS10060	COG3460	Phenylacetate-CoA oxygenase
A8C75_RS10065	COG3396	Phenylacetate-CoA oxygenase
A8C75_RS10075	COG0183	Belongs to the thiolase family
A8C75_RS10080	COG2050	protein possibly involved in aromatic compounds catabolism
A8C75_RS10085	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C75_RS10090	COG1024	Enoyl-CoA hydratase
A8C75_RS10095	COG1024	Enoyl-CoA hydratase
A8C75_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS10110	COG1024	Enoyl-CoA hydratase
A8C75_RS10115	COG0583	DNA-binding transcription factor activity
A8C75_RS10120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C75_RS10140	COG0564	pseudouridine synthase activity
A8C75_RS10155	COG5433	transposase activity
A8C75_RS10175	COG1757	Na H antiporter
A8C75_RS10235	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A8C75_RS10245	COG0095	Lipoate-protein ligase
A8C75_RS10250	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C75_RS10260	COG0022	dehydrogenase e1 component
A8C75_RS10265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8C75_RS10270	COG2197	response regulator
A8C75_RS10275	COG3284	Transcriptional regulator
A8C75_RS10300	COG0842	Transport permease protein
A8C75_RS10305	COG1131	(ABC) transporter
A8C75_RS10310	COG0517	IMP dehydrogenase activity
A8C75_RS10330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C75_RS10340	COG4770	biotin carboxylase activity
A8C75_RS10345	COG1024	Enoyl-CoA hydratase
A8C75_RS10350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8C75_RS10355	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS10360	COG1309	transcriptional regulator
A8C75_RS10365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8C75_RS10380	COG4566	intracellular signal transduction
A8C75_RS10385	COG4191	Histidine kinase
A8C75_RS10425	COG2871	sodium ion transport
A8C75_RS10430	COG1959	2 iron, 2 sulfur cluster binding
A8C75_RS10450	COG0583	DNA-binding transcription factor activity
A8C75_RS10455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C75_RS10455	COG4191	Histidine kinase
A8C75_RS10460	COG2204	response regulator
A8C75_RS10470	COG1301	dicarboxylic acid transport
A8C75_RS10500	COG0683	leucine binding
A8C75_RS10525	COG3135	benzoate transporter
A8C75_RS10530	COG0183	Belongs to the thiolase family
A8C75_RS10550	COG0583	DNA-binding transcription factor activity
A8C75_RS10555	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS10565	COG3314	Sporulation integral membrane protein YlbJ
A8C75_RS10580	COG0583	DNA-binding transcription factor activity
A8C75_RS10605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS10620	COG0625	glutathione transferase activity
A8C75_RS10630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A8C75_RS10670	COG0714	Associated with various cellular activities
A8C75_RS10685	COG1573	uracil-dna glycosylase
A8C75_RS10695	COG0583	DNA-binding transcription factor activity
A8C75_RS10725	COG2202	Pas domain
A8C75_RS10725	COG2205	protein histidine kinase activity
A8C75_RS10750	COG2315	Protein conserved in bacteria
A8C75_RS10760	COG1131	(ABC) transporter
A8C75_RS10780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8C75_RS10785	COG0583	DNA-binding transcription factor activity
A8C75_RS10795	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS10815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS10820	COG2271	Major facilitator Superfamily
A8C75_RS10825	COG0251	oxidation-reduction process
A8C75_RS10845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS10850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS10865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS10880	COG4989	oxidoreductase activity
A8C75_RS10885	COG2186	Transcriptional regulator
A8C75_RS10890	COG0673	inositol 2-dehydrogenase activity
A8C75_RS10915	COG1126	abc transporter atp-binding protein
A8C75_RS10920	COG0765	amino acid transport
A8C75_RS10925	COG0765	amino acid transport
A8C75_RS10930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C75_RS10965	COG3284	Transcriptional regulator
A8C75_RS10970	COG2223	nitrite transmembrane transporter activity
A8C75_RS10975	COG3852	Histidine kinase
A8C75_RS11030	COG1175	transmembrane transport
A8C75_RS11035	COG0395	ABC-type sugar transport system, permease component
A8C75_RS11045	COG1621	beta-fructofuranosidase activity
A8C75_RS11050	COG5433	transposase activity
A8C75_RS11070	COG1609	Transcriptional regulator
A8C75_RS11095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C75_RS11135	COG1175	transmembrane transport
A8C75_RS11140	COG0395	ABC-type sugar transport system, permease component
A8C75_RS11145	COG3842	ATPase activity
A8C75_RS11150	COG0667	Aldo Keto reductase
A8C75_RS11160	COG0738	Major facilitator superfamily
A8C75_RS11175	COG0346	lactoylglutathione lyase activity
A8C75_RS11195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8C75_RS11210	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A8C75_RS11220	COG4143	(ABC) transporter
A8C75_RS11235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C75_RS11240	COG1113	amino acid transport
A8C75_RS11260	COG2072	flavoprotein involved in K transport
A8C75_RS11265	COG0583	DNA-binding transcription factor activity
A8C75_RS11270	COG1027	Aspartate ammonia-lyase
A8C75_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS11285	COG3257	ureidoglycine aminohydrolase activity
A8C75_RS11310	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C75_RS11315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8C75_RS11340	COG0215	cysteine-tRNA ligase activity
A8C75_RS11365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8C75_RS11400	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8C75_RS11405	COG0740	serine-type endopeptidase activity
A8C75_RS11410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8C75_RS11425	COG0322	excinuclease ABC activity
A8C75_RS11455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A8C75_RS11460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8C75_RS11460	COG2169	Transcriptional regulator
A8C75_RS11480	COG2197	response regulator
A8C75_RS11495	COG0210	DNA helicase
A8C75_RS11505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS11510	COG1757	Na H antiporter
A8C75_RS11520	COG0174	glutamine synthetase
A8C75_RS11525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8C75_RS11530	COG1917	Cupin 2, conserved barrel domain protein
A8C75_RS11530	COG1396	sequence-specific DNA binding
A8C75_RS11560	COG0022	dehydrogenase e1 component
A8C75_RS11570	COG5642	Protein of unknown function (DUF2384)
A8C75_RS11655	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A8C75_RS11665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A8C75_RS11695	COG1196	nuclear chromosome segregation
A8C75_RS11705	COG0714	Associated with various cellular activities
A8C75_RS11710	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A8C75_RS11720	COG0189	ligase activity
A8C75_RS11720	COG0569	domain protein
A8C75_RS11770	COG0837	glucose binding
A8C75_RS11795	COG3119	arylsulfatase activity
A8C75_RS11805	COG0667	Aldo Keto reductase
A8C75_RS11810	COG0583	DNA-binding transcription factor activity
A8C75_RS11815	COG1051	belongs to the nudix hydrolase family
A8C75_RS11820	COG2259	Doxx family
A8C75_RS11830	COG2176	DNA-directed DNA polymerase activity
A8C75_RS11855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8C75_RS11860	COG2971	BadF BadG BcrA BcrD
A8C75_RS11865	COG0363	glucosamine-6-phosphate deaminase activity
A8C75_RS11875	COG1175	transmembrane transport
A8C75_RS11880	COG0395	ABC-type sugar transport system, permease component
A8C75_RS11885	COG3842	ATPase activity
A8C75_RS11890	COG2188	Transcriptional regulator
A8C75_RS11905	COG1484	DNA-dependent DNA replication
A8C75_RS11910	COG4584	PFAM Integrase catalytic
A8C75_RS11940	COG1742	UPF0060 membrane protein
A8C75_RS11960	COG2814	Major facilitator Superfamily
A8C75_RS11970	COG0714	Associated with various cellular activities
A8C75_RS12005	COG0300	oxidoreductase activity
A8C75_RS12020	COG0076	glutamate decarboxylase activity
A8C75_RS12025	COG0646	methionine synthase
A8C75_RS12025	COG1410	methionine synthase
A8C75_RS12070	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS12075	COG0579	oxidoreductase
A8C75_RS12090	COG2204	response regulator
A8C75_RS12095	COG4191	Histidine kinase
A8C75_RS12115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C75_RS12120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8C75_RS12125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8C75_RS12130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8C75_RS12135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8C75_RS12140	COG1674	ftsk spoiiie
A8C75_RS12145	COG0492	ferredoxin-NADP+ reductase activity
A8C75_RS12150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A8C75_RS12155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A8C75_RS12160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8C75_RS12165	COG0542	response to heat
A8C75_RS12170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A8C75_RS12175	COG1278	Cold shock
A8C75_RS12185	COG1187	pseudouridine synthase activity
A8C75_RS12190	COG0314	molybdopterin synthase activity
A8C75_RS12205	COG2915	High frequency lysogenization protein hflD homolog
A8C75_RS12225	COG2850	peptidyl-arginine hydroxylation
A8C75_RS12230	COG0625	glutathione transferase activity
A8C75_RS12240	COG1288	antiporter activity
A8C75_RS12245	COG4266	Belongs to the allantoicase family
A8C75_RS12250	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A8C75_RS12255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8C75_RS12260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C75_RS12270	COG5002	protein histidine kinase activity
A8C75_RS12270	COG5001	Diguanylate cyclase
A8C75_RS12270	COG3447	MASE1 domain protein
A8C75_RS12280	COG1686	Belongs to the peptidase S11 family
A8C75_RS12285	COG0418	dihydroorotase activity
A8C75_RS12290	COG1196	nuclear chromosome segregation
A8C75_RS12290	COG0741	lytic transglycosylase activity
A8C75_RS12290	COG0739	heme binding
A8C75_RS12295	COG2186	Transcriptional regulator
A8C75_RS12300	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS12305	COG1063	alcohol dehydrogenase
A8C75_RS12310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS12315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS12315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS12320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS12325	COG1312	Catalyzes the dehydration of D-mannonate
A8C75_RS12330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C75_RS12355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS12365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8C75_RS12370	COG0583	DNA-binding transcription factor activity
A8C75_RS12375	COG1346	cytolysis
A8C75_RS12385	COG1414	Transcriptional regulator
A8C75_RS12390	COG0247	lactate metabolic process
A8C75_RS12395	COG0277	FAD linked oxidase domain protein
A8C75_RS12400	COG0277	FAD linked oxidase domain protein
A8C75_RS12410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8C75_RS12415	COG0469	pyruvate kinase activity
A8C75_RS12425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS12430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS12435	COG0287	Prephenate dehydrogenase
A8C75_RS12440	COG2186	Transcriptional regulator
A8C75_RS12450	COG1850	ribulose-bisphosphate carboxylase activity
A8C75_RS12470	COG3960	tartronate-semialdehyde synthase activity
A8C75_RS12475	COG3622	Belongs to the hyi family
A8C75_RS12480	COG2084	Dehydrogenase
A8C75_RS12510	COG0625	glutathione transferase activity
A8C75_RS12515	COG0625	glutathione transferase activity
A8C75_RS12535	COG2197	response regulator
A8C75_RS12540	COG0625	glutathione transferase activity
A8C75_RS12545	COG3588	fructose-bisphosphate aldolase
A8C75_RS12575	COG3386	PFAM SMP-30 Gluconolaconase
A8C75_RS12595	COG3243	poly(R)-hydroxyalkanoic acid synthase
A8C75_RS12665	COG0535	radical SAM domain protein
A8C75_RS12675	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A8C75_RS12680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8C75_RS12685	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS12700	COG2267	carboxylic ester hydrolase activity
A8C75_RS12725	COG1049	propionate catabolic process, 2-methylcitrate cycle
A8C75_RS12730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8C75_RS12730	COG0392	lysyltransferase activity
A8C75_RS12755	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A8C75_RS12770	COG1355	regulation of microtubule-based process
A8C75_RS12800	COG1286	toxin biosynthetic process
A8C75_RS12810	COG0285	dihydrofolate synthase activity
A8C75_RS12815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8C75_RS12820	COG0159	tryptophan synthase activity
A8C75_RS12825	COG0133	tryptophan synthase activity
A8C75_RS12830	COG0135	phosphoribosylanthranilate isomerase activity
A8C75_RS12845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8C75_RS12850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8C75_RS12855	COG0473	3-isopropylmalate dehydrogenase activity
A8C75_RS12860	COG0066	3-isopropylmalate dehydratase activity
A8C75_RS12865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8C75_RS12880	COG3243	poly(R)-hydroxyalkanoic acid synthase
A8C75_RS12885	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A8C75_RS12905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8C75_RS12945	COG2062	phosphohistidine phosphatase, SixA
A8C75_RS12950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8C75_RS12960	COG1199	ATP-dependent helicase activity
A8C75_RS12965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8C75_RS13005	COG0589	response to stress
A8C75_RS13010	COG0488	(ABC) transporter
A8C75_RS13030	COG3243	poly(R)-hydroxyalkanoic acid synthase
A8C75_RS13055	COG0435	Glutathione S-transferase
A8C75_RS13065	COG3287	FIST C domain
A8C75_RS13065	COG2200	EAL domain
A8C75_RS13065	COG2199	diguanylate cyclase activity
A8C75_RS13070	COG3118	belongs to the thioredoxin family
A8C75_RS13075	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A8C75_RS13080	COG0425	Belongs to the sulfur carrier protein TusA family
A8C75_RS13095	COG3278	Belongs to the heme-copper respiratory oxidase family
A8C75_RS13110	COG2010	Cytochrome c
A8C75_RS13115	COG0348	domain, Protein
A8C75_RS13125	COG2217	Heavy metal translocating P-type atpase
A8C75_RS13140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8C75_RS13145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8C75_RS13150	COG2974	May be involved in recombination
A8C75_RS13155	COG0602	queuosine metabolic process
A8C75_RS13165	COG1739	Uncharacterized protein family UPF0029
A8C75_RS13175	COG3706	GGDEF domain
A8C75_RS13185	COG0442	prolyl-tRNA aminoacylation
A8C75_RS13190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A8C75_RS13195	COG1254	Belongs to the acylphosphatase family
A8C75_RS13200	COG1295	ribonuclease BN
A8C75_RS13205	COG1393	Belongs to the ArsC family
A8C75_RS13220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8C75_RS13235	COG1132	(ABC) transporter
A8C75_RS13255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8C75_RS13275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8C75_RS13280	COG4608	Belongs to the ABC transporter superfamily
A8C75_RS13285	COG0444	Belongs to the ABC transporter superfamily
A8C75_RS13290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C75_RS13295	COG0601	transmembrane transport
A8C75_RS13300	COG0747	negative chemotaxis
A8C75_RS13315	COG0402	S-adenosylhomocysteine deaminase activity
A8C75_RS13335	COG0513	Belongs to the DEAD box helicase family
A8C75_RS13345	COG0419	ATPase involved in DNA repair
A8C75_RS13350	COG0420	3'-5' exonuclease activity
A8C75_RS13355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C75_RS13360	COG2902	Dehydrogenase
A8C75_RS13370	COG2995	paraquat-inducible protein a
A8C75_RS13375	COG1643	Atp-dependent helicase
A8C75_RS13385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A8C75_RS13390	COG2894	cell division
A8C75_RS13395	COG0850	regulation of cytokinetic process
A8C75_RS13405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8C75_RS13410	COG1047	Peptidyl-prolyl cis-trans
A8C75_RS13415	COG0513	Belongs to the DEAD box helicase family
A8C75_RS13420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C75_RS13425	COG0513	Belongs to the DEAD box helicase family
A8C75_RS13430	COG0791	NLP P60 protein
A8C75_RS13435	COG1605	Chorismate mutase
A8C75_RS13435	COG0077	Prephenate dehydratase
A8C75_RS13440	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS13450	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8C75_RS13455	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8C75_RS13460	COG1129	ABC transporter
A8C75_RS13465	COG1879	ABC-type sugar transport system periplasmic component
A8C75_RS13475	COG0583	DNA-binding transcription factor activity
A8C75_RS13490	COG3119	arylsulfatase activity
A8C75_RS13505	COG3485	protocatechuate 3,4-dioxygenase
A8C75_RS13515	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS13525	COG2066	Belongs to the glutaminase family
A8C75_RS13540	COG3181	Tripartite tricarboxylate transporter family receptor
A8C75_RS13550	COG0473	3-isopropylmalate dehydrogenase activity
A8C75_RS13555	COG0583	DNA-binding transcription factor activity
A8C75_RS13560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A8C75_RS13565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A8C75_RS13570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8C75_RS13580	COG0697	spore germination
A8C75_RS13595	COG0246	Mannitol dehydrogenase
A8C75_RS13610	COG0431	NADPH-dependent FMN reductase
A8C75_RS13610	COG3976	FMN-binding domain protein
A8C75_RS13610	COG1053	succinate dehydrogenase
A8C75_RS13615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS13625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS13640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C75_RS13650	COG0583	DNA-binding transcription factor activity
A8C75_RS13660	COG3718	enzyme involved in inositol metabolism
A8C75_RS13670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C75_RS13675	COG3962	Belongs to the TPP enzyme family
A8C75_RS13690	COG0386	Belongs to the glutathione peroxidase family
A8C75_RS13700	COG1492	cobalamin metabolic process
A8C75_RS13710	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A8C75_RS13715	COG0778	Nitroreductase
A8C75_RS13730	COG4206	TonB-dependent receptor
A8C75_RS13735	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C75_RS13735	COG1024	Enoyl-CoA hydratase
A8C75_RS13755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8C75_RS13760	COG1119	ATPase activity
A8C75_RS13765	COG0513	Belongs to the DEAD box helicase family
A8C75_RS13805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS13805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS13815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS13825	COG3321	synthase
A8C75_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS13825	COG0604	alcohol dehydrogenase
A8C75_RS13840	COG3706	GGDEF domain
A8C75_RS13845	COG3214	Protein conserved in bacteria
A8C75_RS13860	COG1404	Belongs to the peptidase S8 family
A8C75_RS13865	COG1132	(ABC) transporter
A8C75_RS13900	COG2226	methyltransferase
A8C75_RS13905	COG3327	negative regulation of DNA-templated transcription, initiation
A8C75_RS13935	COG3038	cytochrome b561
A8C75_RS13940	COG2353	YceI-like domain
A8C75_RS13950	COG1280	lysine exporter protein (LysE YggA)
A8C75_RS13955	COG3122	Protein conserved in bacteria
A8C75_RS13975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A8C75_RS13990	COG1278	Cold shock
A8C75_RS13995	COG0189	ligase activity
A8C75_RS14005	COG3842	ATPase activity
A8C75_RS14010	COG0395	ABC-type sugar transport system, permease component
A8C75_RS14015	COG1175	transmembrane transport
A8C75_RS14025	COG0583	DNA-binding transcription factor activity
A8C75_RS14030	COG3119	arylsulfatase activity
A8C75_RS14035	COG0189	ligase activity
A8C75_RS14040	COG4067	protein conserved in archaea
A8C75_RS14040	COG0189	ligase activity
A8C75_RS14050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8C75_RS14060	COG0793	Belongs to the peptidase S41A family
A8C75_RS14065	COG0583	DNA-binding transcription factor activity
A8C75_RS14070	COG2259	Doxx family
A8C75_RS14075	COG3384	dioxygenase
A8C75_RS14095	COG0784	Response regulator, receiver
A8C75_RS14100	COG4251	negative regulation of phosphorylation
A8C75_RS14105	COG2205	protein histidine kinase activity
A8C75_RS14105	COG0784	Response regulator, receiver
A8C75_RS14115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8C75_RS14130	COG3273	potassium ion transport
A8C75_RS14130	COG0471	metal ion transport
A8C75_RS14150	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8C75_RS14160	COG1944	ATP diphosphatase activity
A8C75_RS14200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8C75_RS14200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8C75_RS14205	COG0509	glycine decarboxylation via glycine cleavage system
A8C75_RS14215	COG1760	l-serine dehydratase
A8C75_RS14220	COG3264	Mechanosensitive ion channel
A8C75_RS14220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A8C75_RS14230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8C75_RS14250	COG1686	Belongs to the peptidase S11 family
A8C75_RS14255	COG0438	transferase activity, transferring glycosyl groups
A8C75_RS14270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8C75_RS14280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS14290	COG0583	DNA-binding transcription factor activity
A8C75_RS14295	COG3048	D-serine ammonia-lyase activity
A8C75_RS14300	COG1115	amino acid carrier protein
A8C75_RS14320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A8C75_RS14330	COG0633	Ferredoxin
A8C75_RS14340	COG2119	membrane
A8C75_RS14345	COG0166	Belongs to the GPI family
A8C75_RS14350	COG1803	Methylglyoxal synthase
A8C75_RS14360	COG1757	Na H antiporter
A8C75_RS14380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8C75_RS14395	COG3181	Tripartite tricarboxylate transporter family receptor
A8C75_RS14400	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS14410	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS14425	COG0673	inositol 2-dehydrogenase activity
A8C75_RS14430	COG1609	Transcriptional regulator
A8C75_RS14435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8C75_RS14465	COG0673	inositol 2-dehydrogenase activity
A8C75_RS14470	COG1082	Xylose isomerase domain protein TIM barrel
A8C75_RS14485	COG1129	ABC transporter
A8C75_RS14490	COG4211	Belongs to the binding-protein-dependent transport system permease family
A8C75_RS14505	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS14510	COG1414	Transcriptional regulator
A8C75_RS14535	COG0583	DNA-binding transcription factor activity
A8C75_RS14545	COG3254	rhamnose metabolic process
A8C75_RS14560	COG1129	ABC transporter
A8C75_RS14565	COG1879	ABC-type sugar transport system periplasmic component
A8C75_RS14575	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS14575	COG3347	Dehydrogenase
A8C75_RS14580	COG4952	isomerase
A8C75_RS14595	COG0149	triose-phosphate isomerase activity
A8C75_RS14675	COG1309	transcriptional regulator
A8C75_RS14680	COG1234	tRNA 3'-trailer cleavage
A8C75_RS14690	COG1070	Carbohydrate kinase
A8C75_RS14695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8C75_RS14705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8C75_RS14710	COG0246	Mannitol dehydrogenase
A8C75_RS14725	COG1175	transmembrane transport
A8C75_RS14750	COG0402	S-adenosylhomocysteine deaminase activity
A8C75_RS14760	COG1609	Transcriptional regulator
A8C75_RS14765	COG2233	PERMEase
A8C75_RS14770	COG0402	S-adenosylhomocysteine deaminase activity
A8C75_RS14790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C75_RS14805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A8C75_RS14830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8C75_RS14850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS14855	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS14860	COG3842	ATPase activity
A8C75_RS14870	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8C75_RS14875	COG1177	transmembrane transport
A8C75_RS14885	COG0556	nucleotide-excision repair
A8C75_RS14890	COG0436	Aminotransferase
A8C75_RS14895	COG1309	transcriptional regulator
A8C75_RS14900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C75_RS14905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8C75_RS14910	COG1538	Outer membrane efflux protein
A8C75_RS14925	COG0717	Belongs to the dCTP deaminase family
A8C75_RS14930	COG0489	protein tyrosine kinase activity
A8C75_RS14935	COG0318	PFAM AMP-dependent synthetase and ligase
A8C75_RS14935	COG0204	Acyl-transferase
A8C75_RS14950	COG0251	oxidation-reduction process
A8C75_RS14955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS14965	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS14970	COG0583	DNA-binding transcription factor activity
A8C75_RS14990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8C75_RS15000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C75_RS15000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C75_RS15005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C75_RS15010	COG4597	amino acid ABC transporter
A8C75_RS15015	COG0765	amino acid transport
A8C75_RS15020	COG1126	abc transporter atp-binding protein
A8C75_RS15030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8C75_RS15060	COG0166	Belongs to the GPI family
A8C75_RS15065	COG1218	3'(2'),5'-bisphosphate nucleotidase
A8C75_RS15080	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS15085	COG3360	Dodecin
A8C75_RS15100	COG2205	protein histidine kinase activity
A8C75_RS15110	COG2204	response regulator
A8C75_RS15115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8C75_RS15130	COG3530	Putative quorum-sensing-regulated virulence factor
A8C75_RS15145	COG2832	Protein of unknown function (DUF454)
A8C75_RS15150	COG1444	tRNA N-acetyltransferase activity
A8C75_RS15155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8C75_RS15175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A8C75_RS15190	COG0405	Gamma-glutamyltransferase
A8C75_RS15200	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A8C75_RS15205	COG0235	Class ii aldolase
A8C75_RS15210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C75_RS15215	COG0436	Aminotransferase
A8C75_RS15235	COG1136	(ABC) transporter
A8C75_RS15245	COG3106	COG3106 Predicted ATPase
A8C75_RS15250	COG3768	UPF0283 membrane protein
A8C75_RS15255	COG2827	Endonuclease containing a URI domain
A8C75_RS15260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8C75_RS15265	COG1522	sequence-specific DNA binding
A8C75_RS15295	COG0023	Translation Initiation Factor
A8C75_RS15305	COG3220	belongs to the UPF0276 family
A8C75_RS15325	COG3806	Anti-sigma factor
A8C75_RS15330	COG1595	DNA-templated transcription, initiation
A8C75_RS15345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8C75_RS15360	COG0300	oxidoreductase activity
A8C75_RS15370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8C75_RS15375	COG2217	Heavy metal translocating P-type atpase
A8C75_RS15390	COG0778	Nitroreductase
A8C75_RS15395	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8C75_RS15395	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8C75_RS15400	COG0842	Transport permease protein
A8C75_RS15405	COG1131	(ABC) transporter
A8C75_RS15425	COG0644	oxidoreductase
A8C75_RS15435	COG5002	protein histidine kinase activity
A8C75_RS15505	COG0745	RESPONSE REGULATOR receiver
A8C75_RS15510	COG5002	protein histidine kinase activity
A8C75_RS15515	COG2205	protein histidine kinase activity
A8C75_RS15515	COG0784	Response regulator, receiver
A8C75_RS15520	COG0745	RESPONSE REGULATOR receiver
A8C75_RS15555	COG1607	acyl-coa hydrolase
A8C75_RS15560	COG1984	allophanate hydrolase subunit 2
A8C75_RS15565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8C75_RS15575	COG0318	PFAM AMP-dependent synthetase and ligase
A8C75_RS15630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8C75_RS15650	COG3267	Type II secretory pathway component ExeA
A8C75_RS15650	COG3409	Peptidoglycan-binding domain 1 protein
A8C75_RS15655	COG2204	response regulator
A8C75_RS15680	COG1450	Type ii and iii secretion system protein
A8C75_RS15695	COG3166	PFAM Fimbrial assembly family protein
A8C75_RS15700	COG3156	type II secretion system protein K
A8C75_RS15710	COG2165	general secretion pathway protein
A8C75_RS15725	COG1459	type II secretion system
A8C75_RS15730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8C75_RS15740	COG5001	Diguanylate cyclase
A8C75_RS15740	COG1716	ATPase activity
A8C75_RS15745	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8C75_RS15750	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A8C75_RS15755	COG3639	organic phosphonate transmembrane transporter activity
A8C75_RS15760	COG2188	Transcriptional regulator
A8C75_RS15765	COG3624	Phosphonate C-P lyase system protein PhnG
A8C75_RS15775	COG3626	phosphonate metabolism
A8C75_RS15780	COG3627	carbon phosphorus lyase activity
A8C75_RS15785	COG4107	phosphonate C-P lyase system protein PhnK
A8C75_RS15790	COG4778	phosphonate C-P lyase system protein PhnL
A8C75_RS15795	COG3454	Phosphonate metabolism
A8C75_RS15800	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A8C75_RS15805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8C75_RS15820	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS15825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8C75_RS15840	COG1902	pentaerythritol trinitrate reductase activity
A8C75_RS15855	COG1082	Xylose isomerase domain protein TIM barrel
A8C75_RS15860	COG0673	inositol 2-dehydrogenase activity
A8C75_RS15870	COG1609	Transcriptional regulator
A8C75_RS15875	COG0673	inositol 2-dehydrogenase activity
A8C75_RS15880	COG1082	Xylose isomerase domain protein TIM barrel
A8C75_RS15895	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A8C75_RS15905	COG2721	sulfolactate sulfo-lyase activity
A8C75_RS15910	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS15920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS15925	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS15930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS15935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS15940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS15945	COG1609	Transcriptional regulator
A8C75_RS15955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8C75_RS15960	COG1842	Phage shock protein A
A8C75_RS15980	COG2801	Transposase and inactivated derivatives
A8C75_RS15985	COG3344	reverse transcriptase
A8C75_RS16010	COG0133	tryptophan synthase activity
A8C75_RS16015	COG0159	tryptophan synthase activity
A8C75_RS16025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C75_RS16030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS16035	COG0348	domain, Protein
A8C75_RS16050	COG1741	Belongs to the pirin family
A8C75_RS16065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A8C75_RS16110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C75_RS16135	COG5507	3-demethylubiquinone-9 3-methyltransferase
A8C75_RS16140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A8C75_RS16145	COG3264	Mechanosensitive ion channel
A8C75_RS16145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A8C75_RS16150	COG4702	Belongs to the UPF0303 family
A8C75_RS16155	COG4175	Glycine betaine
A8C75_RS16155	COG3448	diguanylate cyclase activity
A8C75_RS16160	COG4176	ABC-type proline glycine betaine transport system permease component
A8C75_RS16170	COG1309	transcriptional regulator
A8C75_RS16175	COG1979	alcohol dehydrogenase
A8C75_RS16180	COG2130	NADP-dependent
A8C75_RS16200	COG1469	GTP cyclohydrolase I activity
A8C75_RS16220	COG4584	PFAM Integrase catalytic
A8C75_RS16225	COG1484	DNA-dependent DNA replication
A8C75_RS16255	COG1929	Belongs to the glycerate kinase type-1 family
A8C75_RS16260	COG3835	regulator
A8C75_RS16265	COG0469	pyruvate kinase activity
A8C75_RS16275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS16295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8C75_RS16295	COG2010	Cytochrome c
A8C75_RS16300	COG2080	2 iron, 2 sulfur cluster binding
A8C75_RS16305	COG2309	aminopeptidase activity
A8C75_RS16310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C75_RS16315	COG0596	Alpha beta hydrolase
A8C75_RS16320	COG3473	Maleate cis-trans isomerase
A8C75_RS16325	COG1335	isochorismatase
A8C75_RS16330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C75_RS16335	COG1846	Transcriptional regulator
A8C75_RS16340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8C75_RS16340	COG2010	Cytochrome c
A8C75_RS16355	COG0653	protein targeting
A8C75_RS16390	COG0129	dihydroxy-acid dehydratase activity
A8C75_RS16405	COG4214	carbohydrate transport
A8C75_RS16415	COG4213	ABC transporter substrate-binding protein
A8C75_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS16435	COG0673	inositol 2-dehydrogenase activity
A8C75_RS16445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8C75_RS16455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8C75_RS16455	COG2226	methyltransferase
A8C75_RS16455	COG0596	Alpha beta hydrolase
A8C75_RS16470	COG0443	Heat shock 70 kDa protein
A8C75_RS16475	COG0443	Heat shock 70 kDa protein
A8C75_RS16485	COG1187	pseudouridine synthase activity
A8C75_RS16490	COG1322	Protein conserved in bacteria
A8C75_RS16500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C75_RS16530	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A8C75_RS16535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8C75_RS16590	COG0583	DNA-binding transcription factor activity
A8C75_RS16595	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS16605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C75_RS16620	COG5433	transposase activity
A8C75_RS16630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS16640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8C75_RS16645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8C75_RS16650	COG1121	(ABC) transporter
A8C75_RS16660	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS16685	COG0776	regulation of translation
A8C75_RS16690	COG0072	phenylalanine-tRNA ligase activity
A8C75_RS16695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8C75_RS16700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8C75_RS16705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8C75_RS16710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8C75_RS16715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8C75_RS16720	COG3290	protein histidine kinase activity
A8C75_RS16745	COG2186	Transcriptional regulator
A8C75_RS16750	COG0247	lactate metabolic process
A8C75_RS16755	COG1139	Iron-sulfur cluster binding protein
A8C75_RS16775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8C75_RS16780	COG0830	nickel cation binding
A8C75_RS16790	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A8C75_RS16795	COG0804	urea catabolic process
A8C75_RS16800	COG0832	Belongs to the urease beta subunit family
A8C75_RS16805	COG0831	urea catabolic process
A8C75_RS16810	COG1272	protein, Hemolysin III
A8C75_RS16820	COG0829	nickel cation binding
A8C75_RS16865	COG0748	coenzyme F420 binding
A8C75_RS16875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8C75_RS16885	COG0515	serine threonine protein kinase
A8C75_RS16885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8C75_RS16900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8C75_RS16935	COG3022	response to hydroperoxide
A8C75_RS16940	COG0667	Aldo Keto reductase
A8C75_RS16950	COG2205	protein histidine kinase activity
A8C75_RS16965	COG2353	YceI-like domain
A8C75_RS16980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C75_RS17000	COG2010	Cytochrome c
A8C75_RS17010	COG1132	(ABC) transporter
A8C75_RS17015	COG1132	(ABC) transporter
A8C75_RS17030	COG1136	(ABC) transporter
A8C75_RS17030	COG0577	efflux transmembrane transporter activity
A8C75_RS17060	COG0583	DNA-binding transcription factor activity
A8C75_RS17070	COG1454	alcohol dehydrogenase
A8C75_RS17080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8C75_RS17085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8C75_RS17110	COG1414	Transcriptional regulator
A8C75_RS17120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS17125	COG0589	response to stress
A8C75_RS17130	COG0659	secondary active sulfate transmembrane transporter activity
A8C75_RS17140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8C75_RS17145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A8C75_RS17160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8C75_RS17165	COG0511	ligase activity, forming carbon-carbon bonds
A8C75_RS17175	COG2264	protein methyltransferase activity
A8C75_RS17195	COG0138	bifunctional purine biosynthesis protein purh
A8C75_RS17200	COG0151	Belongs to the GarS family
A8C75_RS17205	COG1280	lysine exporter protein (LysE YggA)
A8C75_RS17220	COG2766	serine protein kinase
A8C75_RS17225	COG2718	Belongs to the UPF0229 family
A8C75_RS17230	COG2719	SpoVR family
A8C75_RS17235	COG0537	adenosine 5'-monophosphoramidase activity
A8C75_RS17240	COG0584	glycerophosphoryl diester phosphodiesterase
A8C75_RS17245	COG2814	Major facilitator Superfamily
A8C75_RS17250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8C75_RS17260	COG1279	arginine transmembrane transporter activity
A8C75_RS17275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8C75_RS17280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C75_RS17295	COG0563	adenylate kinase activity
A8C75_RS17300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A8C75_RS17305	COG3956	TIGRFAM MazG family protein
A8C75_RS17310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8C75_RS17320	COG0736	holo-[acyl-carrier-protein] synthase activity
A8C75_RS17335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8C75_RS17340	COG0571	ribonuclease III activity
A8C75_RS17350	COG0681	Belongs to the peptidase S26 family
A8C75_RS17355	COG0481	GTPase activity
A8C75_RS17360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C75_RS17365	COG3086	response to oxidative stress
A8C75_RS17420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8C75_RS17425	COG1160	GTP binding
A8C75_RS17435	COG2976	Protein conserved in bacteria
A8C75_RS17440	COG0124	histidyl-tRNA synthetase
A8C75_RS17455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8C75_RS17460	COG0105	UTP biosynthetic process
A8C75_RS17470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A8C75_RS17480	COG0330	HflC and HflK could
A8C75_RS17485	COG0330	HflC and HflK could
A8C75_RS17490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8C75_RS17495	COG1923	regulation of RNA biosynthetic process
A8C75_RS17510	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8C75_RS17515	COG0802	atpase or kinase
A8C75_RS17520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A8C75_RS17520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8C75_RS17530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A8C75_RS17535	COG1162	GTPase activity
A8C75_RS17550	COG0688	phosphatidylethanolamine metabolic process
A8C75_RS17555	COG0354	folic acid binding
A8C75_RS17590	COG2204	response regulator
A8C75_RS17595	COG2205	protein histidine kinase activity
A8C75_RS17600	COG1271	oxidase subunit
A8C75_RS17605	COG1294	oxidase, subunit
A8C75_RS17615	COG1802	Transcriptional regulator
A8C75_RS17655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8C75_RS17660	COG0583	DNA-binding transcription factor activity
A8C75_RS17720	COG0154	amidase activity
A8C75_RS17730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS17745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8C75_RS17765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS17765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS17775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS17780	COG1802	Transcriptional regulator
A8C75_RS17785	COG1902	pentaerythritol trinitrate reductase activity
A8C75_RS17815	COG0154	amidase activity
A8C75_RS17840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS17845	COG0154	amidase activity
A8C75_RS17870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS17885	COG1802	Transcriptional regulator
A8C75_RS17890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8C75_RS17900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8C75_RS17905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8C75_RS17945	COG0795	lipopolysaccharide-transporting ATPase activity
A8C75_RS17950	COG0795	lipopolysaccharide-transporting ATPase activity
A8C75_RS17975	COG0577	efflux transmembrane transporter activity
A8C75_RS17975	COG1136	(ABC) transporter
A8C75_RS17980	COG0577	efflux transmembrane transporter activity
A8C75_RS17980	COG1136	(ABC) transporter
A8C75_RS17985	COG0577	efflux transmembrane transporter activity
A8C75_RS17985	COG1136	(ABC) transporter
A8C75_RS17990	COG0525	valine-tRNA ligase activity
A8C75_RS17995	COG0583	DNA-binding transcription factor activity
A8C75_RS18000	COG0667	Aldo Keto reductase
A8C75_RS18005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS18010	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS18015	COG0114	fumarate hydratase activity
A8C75_RS18025	COG1733	regulation of RNA biosynthetic process
A8C75_RS18030	COG2962	Rard protein
A8C75_RS18070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C75_RS18135	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A8C75_RS18155	COG1278	Cold shock
A8C75_RS18160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8C75_RS18165	COG0488	(ABC) transporter
A8C75_RS18175	COG0693	protein deglycase activity
A8C75_RS18190	COG1115	amino acid carrier protein
A8C75_RS18195	COG1027	Aspartate ammonia-lyase
A8C75_RS18200	COG0252	asparaginase activity
A8C75_RS18215	COG0789	Transcriptional regulator
A8C75_RS18230	COG0588	phosphoglycerate mutase activity
A8C75_RS18240	COG3842	ATPase activity
A8C75_RS18245	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8C75_RS18255	COG1349	DNA-binding transcription factor activity
A8C75_RS18260	COG4191	Histidine kinase
A8C75_RS18270	COG0697	spore germination
A8C75_RS18280	COG2027	D-alanyl-D-alanine carboxypeptidase
A8C75_RS18305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8C75_RS18320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS18355	COG1047	Peptidyl-prolyl cis-trans
A8C75_RS18365	COG0259	pyridoxamine-phosphate oxidase activity
A8C75_RS18370	COG2995	paraquat-inducible protein a
A8C75_RS18375	COG3008	intermembrane lipid transfer
A8C75_RS18390	COG2267	carboxylic ester hydrolase activity
A8C75_RS18405	COG0436	Aminotransferase
A8C75_RS18410	COG1393	Belongs to the ArsC family
A8C75_RS18420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C75_RS18425	COG2226	methyltransferase
A8C75_RS18450	COG0697	spore germination
A8C75_RS18515	COG2193	ferroxidase activity
A8C75_RS18545	COG1854	S-ribosylhomocysteine lyase activity
A8C75_RS18555	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A8C75_RS18565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8C75_RS18565	COG0678	peroxiredoxin activity
A8C75_RS18570	COG1285	pathogenesis
A8C75_RS18610	COG0513	Belongs to the DEAD box helicase family
A8C75_RS18615	COG5433	transposase activity
A8C75_RS18660	COG3209	COG3209 Rhs family protein
A8C75_RS18690	COG1120	ATPase activity
A8C75_RS18695	COG0390	transport system, permease component
A8C75_RS18705	COG0183	Belongs to the thiolase family
A8C75_RS18710	COG1024	Enoyl-CoA hydratase
A8C75_RS18710	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C75_RS18715	COG1024	Enoyl-CoA hydratase
A8C75_RS18740	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS18750	COG2409	Drug exporters of the RND superfamily
A8C75_RS18755	COG4447	cellulose binding
A8C75_RS18785	COG0745	RESPONSE REGULATOR receiver
A8C75_RS18790	COG2176	DNA-directed DNA polymerase activity
A8C75_RS18790	COG5002	protein histidine kinase activity
A8C75_RS18800	COG5002	protein histidine kinase activity
A8C75_RS18815	COG0450	alkyl hydroperoxide reductase
A8C75_RS18830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8C75_RS18855	COG0583	DNA-binding transcription factor activity
A8C75_RS18860	COG2828	Protein conserved in bacteria
A8C75_RS18880	COG0729	surface antigen
A8C75_RS18895	COG2186	Transcriptional regulator
A8C75_RS18900	COG3618	amidohydrolase
A8C75_RS18905	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS18910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS18920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS18925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C75_RS18935	COG4948	Mandelate Racemase Muconate Lactonizing
A8C75_RS18945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C75_RS18955	COG0861	Integral membrane protein TerC family
A8C75_RS18960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C75_RS18970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C75_RS18980	COG0747	negative chemotaxis
A8C75_RS18995	COG2186	Transcriptional regulator
A8C75_RS19005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C75_RS19010	COG2721	sulfolactate sulfo-lyase activity
A8C75_RS19030	COG1609	Transcriptional regulator
A8C75_RS19035	COG0583	DNA-binding transcription factor activity
A8C75_RS19045	COG0252	asparaginase activity
A8C75_RS19055	COG3263	regulation of cellular component size
A8C75_RS19060	COG2814	Major facilitator Superfamily
A8C75_RS19065	COG0251	oxidation-reduction process
A8C75_RS19070	COG1832	CoA-binding protein
A8C75_RS19075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C75_RS19080	COG2890	protein-(glutamine-N5) methyltransferase activity
A8C75_RS19085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8C75_RS19090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8C75_RS19110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8C75_RS19115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8C75_RS19120	COG0193	aminoacyl-tRNA hydrolase activity
A8C75_RS19125	COG0012	GTP binding
A8C75_RS19155	COG0560	Phosphoserine phosphatase
A8C75_RS19155	COG3830	Belongs to the UPF0237 family
A8C75_RS19160	COG0586	Pfam SNARE associated Golgi protein
A8C75_RS19165	COG0557	exoribonuclease II activity
A8C75_RS19180	COG1862	Preprotein translocase
A8C75_RS19185	COG0343	queuine tRNA-ribosyltransferase activity
A8C75_RS19190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8C75_RS19210	COG1522	sequence-specific DNA binding
A8C75_RS19235	COG1024	Enoyl-CoA hydratase
A8C75_RS19245	COG1960	acyl-CoA dehydrogenase activity
A8C75_RS19255	COG2124	cytochrome p450
A8C75_RS19265	COG0183	Belongs to the thiolase family
A8C75_RS19270	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C75_RS19275	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS19295	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS19315	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS19345	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C75_RS19395	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS19405	COG2124	cytochrome p450
A8C75_RS19415	COG1309	transcriptional regulator
A8C75_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS19425	COG1024	Enoyl-CoA hydratase
A8C75_RS19455	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS19460	COG0386	Belongs to the glutathione peroxidase family
A8C75_RS19465	COG1063	alcohol dehydrogenase
A8C75_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS19475	COG3025	triphosphatase activity
A8C75_RS19480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8C75_RS19490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A8C75_RS19490	COG1672	PFAM Archaeal ATPase
A8C75_RS19495	COG0473	3-isopropylmalate dehydrogenase activity
A8C75_RS19510	COG3181	Tripartite tricarboxylate transporter family receptor
A8C75_RS19520	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS19525	COG2721	sulfolactate sulfo-lyase activity
A8C75_RS19535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8C75_RS19540	COG0402	S-adenosylhomocysteine deaminase activity
A8C75_RS19550	COG2855	membrane
A8C75_RS19575	COG0583	DNA-binding transcription factor activity
A8C75_RS19580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C75_RS19585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8C75_RS19605	COG0625	glutathione transferase activity
A8C75_RS19615	COG0471	metal ion transport
A8C75_RS19620	COG0596	Alpha beta hydrolase
A8C75_RS19625	COG0583	DNA-binding transcription factor activity
A8C75_RS19630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8C75_RS19635	COG0066	3-isopropylmalate dehydratase activity
A8C75_RS19640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8C75_RS19655	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A8C75_RS19660	COG0515	serine threonine protein kinase
A8C75_RS19660	COG2815	serine threonine protein kinase
A8C75_RS19665	COG2116	formate transmembrane transporter activity
A8C75_RS19670	COG2814	Major facilitator Superfamily
A8C75_RS19675	COG0583	DNA-binding transcription factor activity
A8C75_RS19700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A8C75_RS19720	COG0784	Response regulator, receiver
A8C75_RS19720	COG2205	protein histidine kinase activity
A8C75_RS19720	COG5002	protein histidine kinase activity
A8C75_RS19740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8C75_RS19750	COG0280	phosphate acetyltransferase
A8C75_RS19760	COG0686	Belongs to the AlaDH PNT family
A8C75_RS19765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS19770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C75_RS19780	COG2022	thiamine diphosphate biosynthetic process
A8C75_RS19820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8C75_RS19875	COG0205	6-phosphofructokinase activity
A8C75_RS19880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A8C75_RS19890	COG0783	Belongs to the Dps family
A8C75_RS19895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C75_RS20030	COG3112	Uncharacterised protein family (UPF0231)
A8C75_RS20035	COG1072	(Pantothenic acid kinase))
A8C75_RS20080	COG4964	Belongs to the GSP D family
A8C75_RS20105	COG5433	transposase activity
A8C75_RS20145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS20165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8C75_RS20170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8C75_RS20180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C75_RS20185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8C75_RS20190	COG1116	anion transmembrane transporter activity
A8C75_RS20195	COG0351	phosphomethylpyrimidine kinase
A8C75_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS20220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8C75_RS20230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C75_RS20235	COG1522	sequence-specific DNA binding
A8C75_RS20240	COG3186	Phenylalanine-4-hydroxylase
A8C75_RS20245	COG2154	pterin-4-alpha-carbinolamine dehydratase
A8C75_RS20255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8C75_RS20260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8C75_RS20265	COG2003	Belongs to the UPF0758 family
A8C75_RS20270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8C75_RS20275	COG0756	dUTP diphosphatase activity
A8C75_RS20280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8C75_RS20285	COG1309	transcriptional regulator
A8C75_RS20295	COG2807	transmembrane transport
A8C75_RS20300	COG2902	Dehydrogenase
A8C75_RS20305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8C75_RS20315	COG3724	N-succinylarginine dihydrolase activity
A8C75_RS20320	COG2861	carbohydrate metabolic process
A8C75_RS20325	COG0793	Belongs to the peptidase S41A family
A8C75_RS20330	COG4942	peptidase
A8C75_RS20335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A8C75_RS20340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C75_RS20350	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A8C75_RS20355	COG1404	Belongs to the peptidase S8 family
A8C75_RS20355	COG4935	Belongs to the peptidase S8 family
A8C75_RS20365	COG1028	Short-chain dehydrogenase reductase Sdr
A8C75_RS20370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS20380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8C75_RS20385	COG2204	response regulator
A8C75_RS20390	COG3447	MASE1 domain protein
A8C75_RS20390	COG5001	Diguanylate cyclase
A8C75_RS20390	COG5002	protein histidine kinase activity
A8C75_RS20465	COG0733	neurotransmitter:sodium symporter activity
A8C75_RS20490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8C75_RS20505	COG3639	organic phosphonate transmembrane transporter activity
A8C75_RS20510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8C75_RS20535	COG1278	Cold shock
A8C75_RS20545	COG0519	Catalyzes the synthesis of GMP from XMP
A8C75_RS20545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8C75_RS20550	COG1177	transmembrane transport
A8C75_RS20555	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8C75_RS20560	COG3842	ATPase activity
A8C75_RS20565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8C75_RS20595	COG0174	glutamine synthetase
A8C75_RS20600	COG1217	gtp-binding protein TYPA
A8C75_RS20610	COG3119	arylsulfatase activity
A8C75_RS20615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS20625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS20625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS20630	COG2942	2-epimerase
A8C75_RS20650	COG1490	D-aminoacyl-tRNA deacylase activity
A8C75_RS20660	COG3647	Membrane
A8C75_RS20665	COG1115	amino acid carrier protein
A8C75_RS20675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8C75_RS20680	COG0583	DNA-binding transcription factor activity
A8C75_RS20705	COG2855	membrane
A8C75_RS20710	COG0583	DNA-binding transcription factor activity
A8C75_RS20715	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A8C75_RS20720	COG2855	membrane
A8C75_RS20730	COG2267	carboxylic ester hydrolase activity
A8C75_RS20745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS20750	COG0583	DNA-binding transcription factor activity
A8C75_RS20755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A8C75_RS20755	COG1672	PFAM Archaeal ATPase
A8C75_RS20760	COG0745	RESPONSE REGULATOR receiver
A8C75_RS20765	COG5002	protein histidine kinase activity
A8C75_RS20810	COG1012	belongs to the aldehyde dehydrogenase family
A8C75_RS20815	COG3302	dmso reductase anchor subunit
A8C75_RS20820	COG0437	4 iron, 4 sulfur cluster binding
A8C75_RS20825	COG0243	molybdopterin cofactor binding
A8C75_RS20860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS20865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS20865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS20870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS20870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS20905	COG0109	protoheme IX farnesyltransferase activity
A8C75_RS20910	COG1612	heme a metabolic process
A8C75_RS20935	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A8C75_RS20945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8C75_RS20945	COG1565	acr, cog1565
A8C75_RS20955	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A8C75_RS20960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8C75_RS20965	COG1183	phosphatidylcholine synthase activity
A8C75_RS20970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8C75_RS20970	COG0519	Catalyzes the synthesis of GMP from XMP
A8C75_RS21000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8C75_RS21000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C75_RS21035	COG1047	Peptidyl-prolyl cis-trans
A8C75_RS21045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8C75_RS21050	COG0196	riboflavin kinase activity
A8C75_RS21055	COG0728	peptidoglycan biosynthetic process
A8C75_RS21060	COG0268	Binds directly to 16S ribosomal RNA
A8C75_RS21065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8C75_RS21070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8C75_RS21080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8C75_RS21085	COG0142	geranyltranstransferase activity
A8C75_RS21090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8C75_RS21100	COG0204	Acyl-transferase
A8C75_RS21105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A8C75_RS21110	COG0315	cyclic pyranopterin monophosphate synthase activity
A8C75_RS21120	COG0303	'Molybdopterin
A8C75_RS21125	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8C75_RS21135	COG1091	dTDP-4-dehydrorhamnose reductase activity
A8C75_RS21145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8C75_RS21155	COG0402	S-adenosylhomocysteine deaminase activity
A8C75_RS21165	COG2252	PERMEase
A8C75_RS21190	COG4266	Belongs to the allantoicase family
A8C75_RS21210	COG2233	PERMEase
A8C75_RS21215	COG1309	transcriptional regulator
A8C75_RS21225	COG3960	tartronate-semialdehyde synthase activity
A8C75_RS21230	COG3622	Belongs to the hyi family
A8C75_RS21235	COG2084	Dehydrogenase
A8C75_RS21240	COG0469	pyruvate kinase activity
A8C75_RS21245	COG4413	Urea transporter
A8C75_RS21255	COG1309	transcriptional regulator
A8C75_RS21275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS21285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8C75_RS21305	COG0022	dehydrogenase e1 component
A8C75_RS21320	COG0203	ribosomal protein L17
A8C75_RS21325	COG0202	RNA polymerase activity
A8C75_RS21335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8C75_RS21340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8C75_RS21350	COG0200	Binds to the 23S rRNA
A8C75_RS21355	COG1841	ribosomal large subunit assembly
A8C75_RS21360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8C75_RS21365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8C75_RS21370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8C75_RS21375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8C75_RS21385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8C75_RS21390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8C75_RS21395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8C75_RS21400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8C75_RS21405	COG0255	Belongs to the universal ribosomal protein uL29 family
A8C75_RS21410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8C75_RS21415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8C75_RS21420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8C75_RS21425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8C75_RS21430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8C75_RS21435	COG0089	rRNA binding
A8C75_RS21440	COG0088	Forms part of the polypeptide exit tunnel
A8C75_RS21445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8C75_RS21450	COG0051	transcription antitermination factor activity, RNA binding
A8C75_RS21455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8C75_RS21460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8C75_RS21470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8C75_RS21480	COG0085	RNA polymerase activity
A8C75_RS21485	COG0222	ribosome binding
A8C75_RS21490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8C75_RS21495	COG0081	regulation of translation
A8C75_RS21500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8C75_RS21520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8C75_RS21550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A8C75_RS21565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8C75_RS21575	COG0730	response to heat
A8C75_RS21590	COG0494	nUDIX hydrolase
A8C75_RS21600	COG0667	Aldo Keto reductase
A8C75_RS21610	COG0509	glycine decarboxylation via glycine cleavage system
A8C75_RS21615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C75_RS21620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C75_RS21625	COG0006	proline dipeptidase activity
A8C75_RS21630	COG3079	Belongs to the UPF0149 family
A8C75_RS21650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8C75_RS21665	COG0165	Argininosuccinate lyase
A8C75_RS21675	COG1587	Uroporphyrinogen-III synthase
A8C75_RS21680	COG2959	enzyme of heme biosynthesis
A8C75_RS21685	COG3071	HemY protein
A8C75_RS21690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8C75_RS21695	COG2841	Protein conserved in bacteria
A8C75_RS21705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8C75_RS21720	COG0248	Ppx GppA phosphatase
A8C75_RS21735	COG0671	phosphoesterase, PA-phosphatase related
A8C75_RS21740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8C75_RS21745	COG1011	Hydrolase
A8C75_RS21750	COG0494	nUDIX hydrolase
A8C75_RS21755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8C75_RS21765	COG4181	ATPase activity
A8C75_RS21770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A8C75_RS21780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8C75_RS21785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8C75_RS21805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS21815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS21820	COG2204	response regulator
A8C75_RS21830	COG2183	response to ionizing radiation
A8C75_RS21835	COG2918	glutathione biosynthetic process
A8C75_RS21855	COG0545	Peptidyl-prolyl cis-trans isomerase
A8C75_RS21865	COG0488	(ABC) transporter
A8C75_RS21875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8C75_RS21920	COG3246	L-lysine catabolic process to acetate
A8C75_RS21925	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C75_RS21955	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A8C75_RS21990	COG1561	YicC-like family, N-terminal region
A8C75_RS22015	COG1942	4-Oxalocrotonate Tautomerase
A8C75_RS22030	COG0625	glutathione transferase activity
A8C75_RS22035	COG0583	DNA-binding transcription factor activity
A8C75_RS22070	COG0739	heme binding
A8C75_RS22075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A8C75_RS22080	COG0316	Belongs to the HesB IscA family
A8C75_RS22085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8C75_RS22090	COG0038	chloride channel
A8C75_RS22120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C75_RS22130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8C75_RS22135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C75_RS22150	COG1489	DNA binding
A8C75_RS22155	COG0436	Aminotransferase
A8C75_RS22160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8C75_RS22165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8C75_RS22170	COG4191	Histidine kinase
A8C75_RS22175	COG2204	response regulator
A8C75_RS22190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8C75_RS22195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8C75_RS22205	COG0183	Belongs to the thiolase family
A8C75_RS22220	COG1187	pseudouridine synthase activity
A8C75_RS22240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8C75_RS22250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8C75_RS22255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8C75_RS22260	COG0195	Participates in both transcription termination and antitermination
A8C75_RS22265	COG0779	Required for maturation of 30S ribosomal subunits
A8C75_RS22280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8C75_RS22285	COG0149	triose-phosphate isomerase activity
A8C75_RS22290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8C75_RS22295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8C75_RS22300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8C75_RS22305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A8C75_RS22315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8C75_RS22320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8C75_RS22325	COG0505	Belongs to the CarA family
A8C75_RS22355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8C75_RS22360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8C75_RS22365	COG0537	adenosine 5'-monophosphoramidase activity
A8C75_RS22370	COG0140	phosphoribosyl-ATP diphosphatase activity
A8C75_RS22375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8C75_RS22380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8C75_RS22395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8C75_RS22410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8C75_RS22415	COG0210	DNA helicase
A8C75_RS22435	COG0573	inorganic phosphate transmembrane transporter activity
A8C75_RS22440	COG0573	inorganic phosphate transmembrane transporter activity
A8C75_RS22445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8C75_RS22450	COG0704	Plays a role in the regulation of phosphate uptake
A8C75_RS22460	COG3161	chorismate lyase activity
A8C75_RS22465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A8C75_RS22490	COG0604	alcohol dehydrogenase
A8C75_RS22505	COG3068	Protein conserved in bacteria
A8C75_RS22515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS22520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A8C75_RS22525	COG1737	Transcriptional regulator
A8C75_RS22535	COG0069	glutamate synthase activity
A8C75_RS22540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8C75_RS22545	COG0733	neurotransmitter:sodium symporter activity
A8C75_RS22555	COG1522	sequence-specific DNA binding
A8C75_RS22560	COG4772	TonB-dependent receptor
A8C75_RS22565	COG1120	ATPase activity
A8C75_RS22570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C75_RS22575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C75_RS22580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8C75_RS22590	COG0019	diaminopimelate decarboxylase activity
A8C75_RS22615	COG0174	glutamine synthetase
A8C75_RS22620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C75_RS22635	COG4584	PFAM Integrase catalytic
A8C75_RS22640	COG1484	DNA-dependent DNA replication
A8C75_RS22645	COG3344	reverse transcriptase
A8C75_RS22655	COG0010	Belongs to the arginase family
A8C75_RS22665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8C75_RS22670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A8C75_RS22675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8C75_RS22695	COG0509	glycine decarboxylation via glycine cleavage system
A8C75_RS22700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8C75_RS22705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8C75_RS22710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8C75_RS22720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8C75_RS22725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8C75_RS22730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8C75_RS22735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8C75_RS22745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8C75_RS22755	COG0356	it plays a direct role in the translocation of protons across the membrane
A8C75_RS22765	COG1475	DNA binding
A8C75_RS22770	COG1192	Involved in chromosome partitioning
A8C75_RS22775	COG0357	Ribosomal RNA small subunit methyltransferase G
A8C75_RS22780	COG0445	tRNA wobble uridine modification
A8C75_RS22785	COG0006	proline dipeptidase activity
A8C75_RS22790	COG0697	spore germination
A8C75_RS22800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8C75_RS22805	COG0706	membrane insertase activity
A8C75_RS22810	COG0594	ribonuclease P activity