locus-tag	class	description
MALG_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MALG_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MALG_RS00025	COG1737	Transcriptional regulator
MALG_RS00040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS00065	COG0583	DNA-binding transcription factor activity
MALG_RS00070	COG0747	negative chemotaxis
MALG_RS00075	COG0444	Belongs to the ABC transporter superfamily
MALG_RS00095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS00100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MALG_RS00105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MALG_RS00110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MALG_RS00115	COG1120	ATPase activity
MALG_RS00125	COG3328	transposase activity
MALG_RS00150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MALG_RS00155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MALG_RS00170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MALG_RS00180	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MALG_RS00185	COG0804	urea catabolic process
MALG_RS00200	COG0832	Belongs to the urease beta subunit family
MALG_RS00205	COG0831	urea catabolic process
MALG_RS00210	COG0829	nickel cation binding
MALG_RS00220	COG0559	Belongs to the binding-protein-dependent transport system permease family
MALG_RS00225	COG1172	Belongs to the binding-protein-dependent transport system permease family
MALG_RS00250	COG0246	Mannitol dehydrogenase
MALG_RS00255	COG1501	Belongs to the glycosyl hydrolase 31 family
MALG_RS00265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MALG_RS00275	COG3250	beta-galactosidase activity
MALG_RS00280	COG2186	Transcriptional regulator
MALG_RS00285	COG1312	Catalyzes the dehydration of D-mannonate
MALG_RS00310	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS00330	COG1175	transmembrane transport
MALG_RS00335	COG3842	ATPase activity
MALG_RS00350	COG0527	aspartate kinase activity
MALG_RS00355	COG1917	Cupin 2, conserved barrel domain protein
MALG_RS00360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MALG_RS00365	COG0456	acetyltransferase
MALG_RS00375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MALG_RS00380	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MALG_RS00405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MALG_RS00420	COG1609	Transcriptional regulator
MALG_RS00425	COG3214	Protein conserved in bacteria
MALG_RS00435	COG0625	glutathione transferase activity
MALG_RS00450	COG0495	leucyl-tRNA aminoacylation
MALG_RS00460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MALG_RS00525	COG3383	formate dehydrogenase (NAD+) activity
MALG_RS00540	COG2084	Dehydrogenase
MALG_RS00545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MALG_RS00555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MALG_RS00570	COG1252	NADH dehydrogenase
MALG_RS00575	COG3830	Belongs to the UPF0237 family
MALG_RS00575	COG0560	Phosphoserine phosphatase
MALG_RS00590	COG1953	Uracil, thiamine, allantoin
MALG_RS00595	COG1194	a g-specific adenine glycosylase
MALG_RS00610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MALG_RS00620	COG0587	DNA-directed DNA polymerase activity
MALG_RS00625	COG0028	Belongs to the TPP enzyme family
MALG_RS00640	COG0803	Belongs to the bacterial solute-binding protein 9 family
MALG_RS00645	COG1121	(ABC) transporter
MALG_RS00650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MALG_RS00655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MALG_RS00660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MALG_RS00665	COG0140	phosphoribosyl-ATP diphosphatase activity
MALG_RS00670	COG0107	imidazoleglycerol-phosphate synthase activity
MALG_RS00675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MALG_RS00690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MALG_RS00710	COG0131	Imidazoleglycerol-phosphate dehydratase
MALG_RS00735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MALG_RS00760	COG0395	ABC-type sugar transport system, permease component
MALG_RS00765	COG1175	transmembrane transport
MALG_RS00770	COG3842	ATPase activity
MALG_RS00775	COG3842	ATPase activity
MALG_RS00785	COG1349	DNA-binding transcription factor activity
MALG_RS00790	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS00805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MALG_RS00825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MALG_RS00830	COG0772	Belongs to the SEDS family
MALG_RS00835	COG0768	penicillin binding
MALG_RS00900	COG2983	Belongs to the UPF0260 family
MALG_RS00905	COG0196	riboflavin kinase activity
MALG_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS00930	COG2814	Major facilitator Superfamily
MALG_RS00940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MALG_RS00950	COG0116	Belongs to the methyltransferase superfamily
MALG_RS00950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MALG_RS00955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MALG_RS00960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MALG_RS00965	COG0277	FAD linked oxidase domain protein
MALG_RS00970	COG0129	dihydroxy-acid dehydratase activity
MALG_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS01025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS01040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS01050	COG2423	ornithine cyclodeaminase activity
MALG_RS01055	COG0583	DNA-binding transcription factor activity
MALG_RS01060	COG0251	oxidation-reduction process
MALG_RS01065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MALG_RS01070	COG0747	negative chemotaxis
MALG_RS01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS01085	COG0444	Belongs to the ABC transporter superfamily
MALG_RS01090	COG4608	Belongs to the ABC transporter superfamily
MALG_RS01100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MALG_RS01105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MALG_RS01110	COG4558	Periplasmic binding protein
MALG_RS01120	COG1629	transport
MALG_RS01135	COG4605	iron ion homeostasis
MALG_RS01140	COG4604	ABC transporter, ATP-binding protein
MALG_RS01160	COG0811	peptide transport
MALG_RS01170	COG3254	rhamnose metabolic process
MALG_RS01180	COG0246	Mannitol dehydrogenase
MALG_RS01190	COG2186	Transcriptional regulator
MALG_RS01195	COG1172	Belongs to the binding-protein-dependent transport system permease family
MALG_RS01210	COG1063	alcohol dehydrogenase
MALG_RS01215	COG2721	sulfolactate sulfo-lyase activity
MALG_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS01225	COG0179	Fumarylacetoacetate (FAA) hydrolase
MALG_RS01235	COG0180	Tryptophanyl-tRNA synthetase
MALG_RS01245	COG0628	permease
MALG_RS01270	COG3237	CsbD-like
MALG_RS01300	COG1295	ribonuclease BN
MALG_RS01325	COG0784	Response regulator, receiver
MALG_RS01350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MALG_RS01355	COG1960	acyl-CoA dehydrogenase activity
MALG_RS01370	COG0427	acetyl-CoA hydrolase
MALG_RS01375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MALG_RS01385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MALG_RS01395	COG2032	superoxide dismutase activity
MALG_RS01410	COG0628	permease
MALG_RS01465	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS01485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MALG_RS01500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MALG_RS01530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MALG_RS01560	COG5328	Belongs to the UPF0262 family
MALG_RS01570	COG0442	prolyl-tRNA aminoacylation
MALG_RS01575	COG0628	permease
MALG_RS01585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MALG_RS01590	COG0798	PFAM Bile acid sodium symporter
MALG_RS01595	COG1115	amino acid carrier protein
MALG_RS01610	COG0248	Ppx GppA phosphatase
MALG_RS01615	COG0525	valine-tRNA ligase activity
MALG_RS01620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MALG_RS01655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MALG_RS01675	COG2423	ornithine cyclodeaminase activity
MALG_RS01680	COG2271	Major facilitator Superfamily
MALG_RS01685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MALG_RS01690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MALG_RS01705	COG1674	ftsk spoiiie
MALG_RS01720	COG0469	pyruvate kinase activity
MALG_RS01730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MALG_RS01735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MALG_RS01740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MALG_RS01745	COG1671	Belongs to the UPF0178 family
MALG_RS01750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MALG_RS01780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MALG_RS01795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MALG_RS01810	COG1793	dna ligase
MALG_RS01830	COG0181	hydroxymethylbilane synthase activity
MALG_RS01835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MALG_RS01840	COG1131	(ABC) transporter
MALG_RS01845	COG0842	Transport permease protein
MALG_RS01850	COG0616	signal peptide processing
MALG_RS01850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MALG_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS01870	COG0322	excinuclease ABC activity
MALG_RS01875	COG0546	phosphoglycolate phosphatase activity
MALG_RS01900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MALG_RS01905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MALG_RS01915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MALG_RS01925	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MALG_RS01940	COG2130	NADP-dependent
MALG_RS01945	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS01950	COG1960	acyl-CoA dehydrogenase activity
MALG_RS01975	COG0730	response to heat
MALG_RS01980	COG1079	Belongs to the binding-protein-dependent transport system permease family
MALG_RS01990	COG3845	ABC transporter
MALG_RS01995	COG1744	ABC transporter substrate-binding protein PnrA-like
MALG_RS02005	COG1214	PFAM Peptidase M22, glycoprotease
MALG_RS02010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MALG_RS02040	COG0284	orotidine-5'-phosphate decarboxylase activity
MALG_RS02045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MALG_RS02050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MALG_RS02100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MALG_RS02100	COG3008	intermembrane lipid transfer
MALG_RS02105	COG2995	paraquat-inducible protein a
MALG_RS02115	COG2814	Major facilitator Superfamily
MALG_RS02155	COG1175	transmembrane transport
MALG_RS02160	COG0395	ABC-type sugar transport system, permease component
MALG_RS02180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MALG_RS02185	COG1122	ATPase activity
MALG_RS02190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MALG_RS02195	COG1268	BioY protein
MALG_RS02205	COG0255	Belongs to the universal ribosomal protein uL29 family
MALG_RS02210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MALG_RS02215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MALG_RS02220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MALG_RS02225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MALG_RS02230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MALG_RS02235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MALG_RS02240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MALG_RS02245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MALG_RS02250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MALG_RS02255	COG1841	ribosomal large subunit assembly
MALG_RS02275	COG0200	Binds to the 23S rRNA
MALG_RS02280	COG0201	protein transport
MALG_RS02285	COG0563	adenylate kinase activity
MALG_RS02300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MALG_RS02305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MALG_RS02310	COG0202	RNA polymerase activity
MALG_RS02315	COG0431	NADPH-dependent FMN reductase
MALG_RS02320	COG0203	ribosomal protein L17
MALG_RS02345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MALG_RS02350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MALG_RS02360	COG0564	pseudouridine synthase activity
MALG_RS02365	COG0546	phosphoglycolate phosphatase activity
MALG_RS02375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MALG_RS02380	COG4597	amino acid ABC transporter
MALG_RS02385	COG0765	amino acid transport
MALG_RS02390	COG1126	abc transporter atp-binding protein
MALG_RS02410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MALG_RS02415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MALG_RS02425	COG0706	membrane insertase activity
MALG_RS02430	COG5001	Diguanylate cyclase
MALG_RS02440	COG0842	Transport permease protein
MALG_RS02455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MALG_RS02465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MALG_RS02470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MALG_RS02475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MALG_RS02485	COG0540	Belongs to the ATCase OTCase family
MALG_RS02490	COG1573	uracil-dna glycosylase
MALG_RS02495	COG0521	Mo-molybdopterin cofactor biosynthetic process
MALG_RS02525	COG0823	Involved in the tonB-independent uptake of proteins
MALG_RS02530	COG2885	chlorophyll binding
MALG_RS02540	COG0037	tRNA processing
MALG_RS02545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MALG_RS02550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MALG_RS02560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MALG_RS02580	COG1201	RNA secondary structure unwinding
MALG_RS02630	COG4964	Belongs to the GSP D family
MALG_RS02685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MALG_RS02695	COG0758	DNA mediated transformation
MALG_RS02700	COG0312	modulator of DNA gyrase
MALG_RS02710	COG0109	protoheme IX farnesyltransferase activity
MALG_RS02720	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MALG_RS02730	COG3346	SURF1 family
MALG_RS02755	COG0277	FAD linked oxidase domain protein
MALG_RS02760	COG0242	peptide deformylase activity
MALG_RS02765	COG0242	peptide deformylase activity
MALG_RS02770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MALG_RS02780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MALG_RS02785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MALG_RS02795	COG1116	anion transmembrane transporter activity
MALG_RS02800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MALG_RS02805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MALG_RS02830	COG1105	Belongs to the carbohydrate kinase PfkB family
MALG_RS02835	COG3128	pkhd-type hydroxylase
MALG_RS02850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MALG_RS02855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MALG_RS02870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MALG_RS02885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MALG_RS02895	COG1496	oxidoreductase activity
MALG_RS02915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MALG_RS02925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MALG_RS02930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MALG_RS02935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MALG_RS02940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MALG_RS02945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MALG_RS02950	COG0133	tryptophan synthase activity
MALG_RS02955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MALG_RS02960	COG1047	Peptidyl-prolyl cis-trans
MALG_RS02970	COG2267	carboxylic ester hydrolase activity
MALG_RS02985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MALG_RS03005	COG4948	Mandelate Racemase Muconate Lactonizing
MALG_RS03010	COG0640	Transcriptional regulator
MALG_RS03025	COG0667	Aldo Keto reductase
MALG_RS03035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MALG_RS03035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MALG_RS03050	COG4770	biotin carboxylase activity
MALG_RS03070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MALG_RS03075	COG2814	Major facilitator Superfamily
MALG_RS03080	COG3800	Transcriptional regulator
MALG_RS03080	COG1396	sequence-specific DNA binding
MALG_RS03100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MALG_RS03115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MALG_RS03125	COG0483	inositol monophosphate 1-phosphatase activity
MALG_RS03135	COG0735	belongs to the Fur family
MALG_RS03145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MALG_RS03155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MALG_RS03160	COG0459	protein refolding
MALG_RS03205	COG1519	Transferase
MALG_RS03210	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS03235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MALG_RS03240	COG0659	secondary active sulfate transmembrane transporter activity
MALG_RS03250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MALG_RS03255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MALG_RS03260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MALG_RS03280	COG0583	DNA-binding transcription factor activity
MALG_RS03285	COG0596	Alpha beta hydrolase
MALG_RS03295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MALG_RS03300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MALG_RS03305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MALG_RS03315	COG0281	malic enzyme
MALG_RS03315	COG0280	phosphate acetyltransferase
MALG_RS03325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MALG_RS03330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MALG_RS03335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MALG_RS03340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MALG_RS03370	COG0348	domain, Protein
MALG_RS03375	COG0583	DNA-binding transcription factor activity
MALG_RS03380	COG2010	Cytochrome c
MALG_RS03415	COG1846	Transcriptional regulator
MALG_RS03440	COG0534	Mate efflux family protein
MALG_RS03450	COG0346	lactoylglutathione lyase activity
MALG_RS03465	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MALG_RS03490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MALG_RS03545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MALG_RS03560	COG1459	type II secretion system
MALG_RS03575	COG1063	alcohol dehydrogenase
MALG_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS03590	COG4948	Mandelate Racemase Muconate Lactonizing
MALG_RS03595	COG0747	negative chemotaxis
MALG_RS03600	COG0601	transmembrane transport
MALG_RS03605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS03610	COG0444	Belongs to the ABC transporter superfamily
MALG_RS03615	COG4608	Belongs to the ABC transporter superfamily
MALG_RS03630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MALG_RS03640	COG1024	Enoyl-CoA hydratase
MALG_RS03645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS03655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS03680	COG1172	Belongs to the binding-protein-dependent transport system permease family
MALG_RS03690	COG1172	Belongs to the binding-protein-dependent transport system permease family
MALG_RS03695	COG1129	ABC transporter
MALG_RS03700	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS03715	COG1609	Transcriptional regulator
MALG_RS03735	COG3842	ATPase activity
MALG_RS03740	COG0395	ABC-type sugar transport system, permease component
MALG_RS03745	COG1175	transmembrane transport
MALG_RS03750	COG1653	transport
MALG_RS03760	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS03765	COG1024	Enoyl-CoA hydratase
MALG_RS03770	COG4670	ketone body catabolic process
MALG_RS03785	COG2151	metal-sulfur cluster biosynthetic enzyme
MALG_RS03785	COG0489	protein tyrosine kinase activity
MALG_RS03795	COG0254	rRNA binding
MALG_RS03800	COG0335	large ribosomal subunit rRNA binding
MALG_RS03805	COG0336	Belongs to the RNA methyltransferase TrmD family
MALG_RS03815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MALG_RS03820	COG0228	four-way junction DNA binding
MALG_RS03840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MALG_RS03845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MALG_RS03870	COG0356	it plays a direct role in the translocation of protons across the membrane
MALG_RS03875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MALG_RS03885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MALG_RS03920	COG1473	amidohydrolase
MALG_RS03925	COG1522	sequence-specific DNA binding
MALG_RS03930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MALG_RS03940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MALG_RS03945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MALG_RS03950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS03955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MALG_RS03965	COG1609	Transcriptional regulator
MALG_RS03975	COG1175	transmembrane transport
MALG_RS03980	COG0395	ABC-type sugar transport system, permease component
MALG_RS03985	COG1621	beta-fructofuranosidase activity
MALG_RS03995	COG3119	arylsulfatase activity
MALG_RS04000	COG3181	Tripartite tricarboxylate transporter family receptor
MALG_RS04015	COG2186	Transcriptional regulator
MALG_RS04020	COG3119	arylsulfatase activity
MALG_RS04040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MALG_RS04045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MALG_RS04050	COG3360	Dodecin
MALG_RS04060	COG0481	GTPase activity
MALG_RS04080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MALG_RS04085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MALG_RS04095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MALG_RS04100	COG0154	amidase activity
MALG_RS04110	COG3023	N-Acetylmuramoyl-L-alanine amidase
MALG_RS04115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MALG_RS04120	COG0670	Belongs to the BI1 family
MALG_RS04130	COG0583	DNA-binding transcription factor activity
MALG_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS04135	COG0604	alcohol dehydrogenase
MALG_RS04135	COG3321	synthase
MALG_RS04140	COG1396	sequence-specific DNA binding
MALG_RS04145	COG0483	inositol monophosphate 1-phosphatase activity
MALG_RS04160	COG0402	S-adenosylhomocysteine deaminase activity
MALG_RS04165	COG2239	Acts as a magnesium transporter
MALG_RS04180	COG1692	metallophosphoesterase
MALG_RS04185	COG0471	metal ion transport
MALG_RS04185	COG3273	potassium ion transport
MALG_RS04195	COG0471	metal ion transport
MALG_RS04195	COG3273	potassium ion transport
MALG_RS04200	COG1846	Transcriptional regulator
MALG_RS04210	COG0217	transcriptional regulatory protein
MALG_RS04215	COG2951	lytic endotransglycosylase activity
MALG_RS04220	COG3920	Histidine kinase
MALG_RS04240	COG1178	ABC-type Fe3 transport system permease component
MALG_RS04245	COG1840	ABC-type Fe3 transport system, periplasmic component
MALG_RS04310	COG0546	phosphoglycolate phosphatase activity
MALG_RS04350	COG1648	precorrin-2 dehydrogenase activity
MALG_RS04350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MALG_RS04355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MALG_RS04360	COG0243	molybdopterin cofactor binding
MALG_RS04365	COG2146	nitrite reductase [NAD(P)H] activity
MALG_RS04370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MALG_RS04380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MALG_RS04380	COG1116	anion transmembrane transporter activity
MALG_RS04385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MALG_RS04390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MALG_RS04390	COG1116	anion transmembrane transporter activity
MALG_RS04395	COG1116	anion transmembrane transporter activity
MALG_RS04395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MALG_RS04400	COG3707	response regulator
MALG_RS04405	COG2076	Multidrug Resistance protein
MALG_RS04410	COG0546	phosphoglycolate phosphatase activity
MALG_RS04410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MALG_RS04440	COG1181	Belongs to the D-alanine--D-alanine ligase family
MALG_RS04445	COG0583	DNA-binding transcription factor activity
MALG_RS04450	COG3181	Tripartite tricarboxylate transporter family receptor
MALG_RS04475	COG1309	transcriptional regulator
MALG_RS04480	COG0673	inositol 2-dehydrogenase activity
MALG_RS04510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS04520	COG0069	glutamate synthase activity
MALG_RS04525	COG2218	PFAM glutamate synthase alpha subunit domain protein
MALG_RS04530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MALG_RS04550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MALG_RS04550	COG0446	pyridine nucleotide-disulphide oxidoreductase
MALG_RS04555	COG4311	Sarcosine oxidase, delta subunit
MALG_RS04560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS04565	COG1349	DNA-binding transcription factor activity
MALG_RS04570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MALG_RS04575	COG1176	ABC-type spermidine putrescine transport system, permease component I
MALG_RS04590	COG0588	phosphoglycerate mutase activity
MALG_RS04610	COG2855	membrane
MALG_RS04615	COG2072	flavoprotein involved in K transport
MALG_RS04635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MALG_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS04670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS04675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS04680	COG1733	regulation of RNA biosynthetic process
MALG_RS04695	COG3119	arylsulfatase activity
MALG_RS04710	COG0583	DNA-binding transcription factor activity
MALG_RS04715	COG4948	Mandelate Racemase Muconate Lactonizing
MALG_RS04725	COG3246	L-lysine catabolic process to acetate
MALG_RS04735	COG2188	Transcriptional regulator
MALG_RS04745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MALG_RS04760	COG0604	alcohol dehydrogenase
MALG_RS04760	COG3321	synthase
MALG_RS04765	COG1294	oxidase, subunit
MALG_RS04770	COG1271	oxidase subunit
MALG_RS04800	COG3328	transposase activity
MALG_RS04820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MALG_RS04825	COG1335	isochorismatase
MALG_RS04850	COG1309	transcriptional regulator
MALG_RS04855	COG1643	Atp-dependent helicase
MALG_RS04865	COG1703	isobutyryl-CoA mutase activity
MALG_RS04875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MALG_RS04890	COG0187	DNA topoisomerase II activity
MALG_RS04920	COG0745	RESPONSE REGULATOR receiver
MALG_RS04955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MALG_RS04960	COG0508	dehydrogenase complex catalyzes the overall conversion of
MALG_RS04965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MALG_RS04970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MALG_RS04975	COG0583	DNA-binding transcription factor activity
MALG_RS04980	COG1278	Cold shock
MALG_RS04985	COG1393	Belongs to the ArsC family
MALG_RS05005	COG0358	DNA primase activity
MALG_RS05010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MALG_RS05035	COG3220	belongs to the UPF0276 family
MALG_RS05045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MALG_RS05080	COG0552	protein localization to endoplasmic reticulum
MALG_RS05100	COG2917	probably involved in intracellular septation
MALG_RS05120	COG1469	GTP cyclohydrolase I activity
MALG_RS05130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MALG_RS05150	COG0489	protein tyrosine kinase activity
MALG_RS05155	COG1120	ATPase activity
MALG_RS05170	COG4206	TonB-dependent receptor
MALG_RS05175	COG2001	Belongs to the MraZ family
MALG_RS05195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MALG_RS05205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MALG_RS05210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MALG_RS05220	COG2081	HI0933 family
MALG_RS05230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MALG_RS05235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MALG_RS05250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MALG_RS05255	COG1181	Belongs to the D-alanine--D-alanine ligase family
MALG_RS05260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MALG_RS05265	COG0849	cell division
MALG_RS05270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MALG_RS05280	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MALG_RS05290	COG0277	FAD linked oxidase domain protein
MALG_RS05295	COG0038	chloride channel
MALG_RS05305	COG0006	proline dipeptidase activity
MALG_RS05330	COG1595	DNA-templated transcription, initiation
MALG_RS05340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MALG_RS05345	COG0484	heat shock protein binding
MALG_RS05360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MALG_RS05380	COG0519	Catalyzes the synthesis of GMP from XMP
MALG_RS05380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MALG_RS05385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MALG_RS05400	COG1570	exodeoxyribonuclease VII activity
MALG_RS05450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MALG_RS05455	COG1329	Transcriptional regulator
MALG_RS05475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MALG_RS05480	COG0583	DNA-binding transcription factor activity
MALG_RS05485	COG2080	2 iron, 2 sulfur cluster binding
MALG_RS05490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MALG_RS05505	COG0402	S-adenosylhomocysteine deaminase activity
MALG_RS05525	COG1172	Belongs to the binding-protein-dependent transport system permease family
MALG_RS05545	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MALG_RS05575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MALG_RS05580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MALG_RS05610	COG5598	trimethylamine methyltransferase
MALG_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS05625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MALG_RS05650	COG0154	amidase activity
MALG_RS05675	COG0583	DNA-binding transcription factor activity
MALG_RS05680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MALG_RS05690	COG1984	allophanate hydrolase subunit 2
MALG_RS05700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MALG_RS05705	COG4597	amino acid ABC transporter
MALG_RS05710	COG0765	amino acid transport
MALG_RS05720	COG0626	cystathionine gamma-synthase activity
MALG_RS05740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS05765	COG0251	oxidation-reduction process
MALG_RS05770	COG1126	abc transporter atp-binding protein
MALG_RS05775	COG1802	Transcriptional regulator
MALG_RS05780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MALG_RS05785	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS05790	COG0179	Fumarylacetoacetate (FAA) hydrolase
MALG_RS05795	COG2188	Transcriptional regulator
MALG_RS05805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MALG_RS05825	COG0179	Fumarylacetoacetate (FAA) hydrolase
MALG_RS05830	COG0778	Nitroreductase
MALG_RS05855	COG3485	protocatechuate 3,4-dioxygenase
MALG_RS05870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MALG_RS05870	COG1648	precorrin-2 dehydrogenase activity
MALG_RS05875	COG1797	cobyrinic acid a,c-diamide synthase activity
MALG_RS05880	COG2875	Belongs to the precorrin methyltransferase family
MALG_RS05895	COG2099	Precorrin-6x reductase
MALG_RS05940	COG1492	cobalamin metabolic process
MALG_RS05950	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MALG_RS05970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MALG_RS05975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MALG_RS05980	COG0778	Nitroreductase
MALG_RS05985	COG1609	Transcriptional regulator
MALG_RS05995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS06000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MALG_RS06005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS06005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MALG_RS06010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MALG_RS06035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MALG_RS06040	COG2855	membrane
MALG_RS06050	COG3119	arylsulfatase activity
MALG_RS06055	COG3119	arylsulfatase activity
MALG_RS06080	COG2186	Transcriptional regulator
MALG_RS06085	COG3284	Transcriptional regulator
MALG_RS06100	COG3246	L-lysine catabolic process to acetate
MALG_RS06105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MALG_RS06110	COG3842	ATPase activity
MALG_RS06125	COG1176	ABC-type spermidine putrescine transport system, permease component I
MALG_RS06130	COG0583	DNA-binding transcription factor activity
MALG_RS06160	COG3350	monooxygenase activity
MALG_RS06190	COG0459	protein refolding
MALG_RS06195	COG1064	alcohol dehydrogenase
MALG_RS06205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MALG_RS06220	COG3119	arylsulfatase activity
MALG_RS06235	COG0395	ABC-type sugar transport system, permease component
MALG_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS06260	COG1609	Transcriptional regulator
MALG_RS06265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MALG_RS06270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MALG_RS06300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MALG_RS06305	COG0235	Class ii aldolase
MALG_RS06310	COG0583	DNA-binding transcription factor activity
MALG_RS06345	COG0019	diaminopimelate decarboxylase activity
MALG_RS06350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MALG_RS06355	COG0730	response to heat
MALG_RS06370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MALG_RS06375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS06400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MALG_RS06400	COG0446	pyridine nucleotide-disulphide oxidoreductase
MALG_RS06425	COG5265	(ABC) transporter
MALG_RS06430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MALG_RS06450	COG1160	GTP binding
MALG_RS06465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MALG_RS06475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MALG_RS06480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MALG_RS06485	COG1862	Preprotein translocase
MALG_RS06490	COG0024	Methionine aminopeptidase
MALG_RS06495	COG3737	Protein of unknown function (DUF498/DUF598)
MALG_RS06500	COG4133	protoheme IX ABC transporter activity
MALG_RS06505	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MALG_RS06510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MALG_RS06540	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MALG_RS06545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MALG_RS06565	COG0482	sulfurtransferase activity
MALG_RS06580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MALG_RS06585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MALG_RS06595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MALG_RS06600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MALG_RS06605	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MALG_RS06610	COG1024	Enoyl-CoA hydratase
MALG_RS06625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MALG_RS06630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MALG_RS06635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MALG_RS06650	COG1309	transcriptional regulator
MALG_RS06655	COG2326	polyphosphate kinase activity
MALG_RS06665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MALG_RS06680	COG0697	spore germination
MALG_RS06690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MALG_RS06725	COG1957	nucleoside hydrolase
MALG_RS06730	COG3956	TIGRFAM MazG family protein
MALG_RS06735	COG0010	Belongs to the arginase family
MALG_RS06745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MALG_RS06750	COG2890	protein-(glutamine-N5) methyltransferase activity
MALG_RS06760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MALG_RS06765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MALG_RS06775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MALG_RS06790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MALG_RS06815	COG2095	MarC family integral membrane protein
MALG_RS06820	COG0488	(ABC) transporter
MALG_RS06825	COG0105	UTP biosynthetic process
MALG_RS06830	COG1051	belongs to the nudix hydrolase family
MALG_RS06850	COG0215	cysteine-tRNA ligase activity
MALG_RS06855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MALG_RS06865	COG2814	Major facilitator Superfamily
MALG_RS06905	COG0488	(ABC) transporter
MALG_RS06935	COG0739	heme binding
MALG_RS06940	COG2833	Protein of unknown function (DUF455)
MALG_RS06945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MALG_RS06955	COG0519	Catalyzes the synthesis of GMP from XMP
MALG_RS06955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MALG_RS06990	COG2154	pterin-4-alpha-carbinolamine dehydratase
MALG_RS06995	COG3186	Phenylalanine-4-hydroxylase
MALG_RS07000	COG1522	sequence-specific DNA binding
MALG_RS07010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MALG_RS07020	COG2010	Cytochrome c
MALG_RS07040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MALG_RS07045	COG2867	negative regulation of translational initiation
MALG_RS07055	COG2267	carboxylic ester hydrolase activity
MALG_RS07060	COG0004	ammonium transporteR
MALG_RS07065	COG1546	Belongs to the CinA family
MALG_RS07065	COG1058	Belongs to the CinA family
MALG_RS07070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MALG_RS07075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MALG_RS07075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MALG_RS07080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MALG_RS07085	COG3852	Histidine kinase
MALG_RS07090	COG2204	response regulator
MALG_RS07095	COG5000	phosphorelay sensor kinase activity
MALG_RS07100	COG2204	response regulator
MALG_RS07115	COG3773	Cell wall hydrolase
MALG_RS07120	COG0569	domain protein
MALG_RS07125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MALG_RS07130	COG1923	regulation of RNA biosynthetic process
MALG_RS07135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MALG_RS07140	COG2366	antibiotic biosynthetic process
MALG_RS07145	COG2084	Dehydrogenase
MALG_RS07150	COG1530	ribonuclease E activity
MALG_RS07155	COG0425	Belongs to the sulfur carrier protein TusA family
MALG_RS07165	COG2124	cytochrome p450
MALG_RS07175	COG2945	thiolester hydrolase activity
MALG_RS07180	COG1959	2 iron, 2 sulfur cluster binding
MALG_RS07190	COG0719	Fe-S assembly protein
MALG_RS07205	COG0396	ATPase activity
MALG_RS07210	COG0719	Fe-S assembly protein
MALG_RS07225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MALG_RS07285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MALG_RS07350	COG3108	Peptidase M15
MALG_RS07355	COG3409	Peptidoglycan-binding domain 1 protein
MALG_RS07355	COG3267	Type II secretory pathway component ExeA
MALG_RS07360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MALG_RS07365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MALG_RS07390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MALG_RS07390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MALG_RS07420	COG0084	hydrolase, TatD family'
MALG_RS07430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MALG_RS07435	COG1686	Belongs to the peptidase S11 family
MALG_RS07470	COG3328	transposase activity
MALG_RS07500	COG0235	Class ii aldolase
MALG_RS07505	COG3395	kinase activity
MALG_RS07510	COG2084	Dehydrogenase
MALG_RS07520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MALG_RS07525	COG1609	Transcriptional regulator
MALG_RS07550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MALG_RS07555	COG0156	8-amino-7-oxononanoate synthase activity
MALG_RS07565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MALG_RS07580	COG0436	Aminotransferase
MALG_RS07585	COG0860	N-Acetylmuramoyl-L-alanine amidase
MALG_RS07590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MALG_RS07595	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MALG_RS07600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MALG_RS07610	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MALG_RS07615	COG1280	lysine exporter protein (LysE YggA)
MALG_RS07620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MALG_RS07625	COG0259	pyridoxamine-phosphate oxidase activity
MALG_RS07630	COG1278	Cold shock
MALG_RS07645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MALG_RS07670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MALG_RS07675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MALG_RS07685	COG1217	gtp-binding protein TYPA
MALG_RS07715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MALG_RS07715	COG2010	Cytochrome c
MALG_RS07720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MALG_RS07740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MALG_RS07740	COG3743	rRNA binding
MALG_RS07745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MALG_RS07755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MALG_RS07760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MALG_RS07765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MALG_RS07805	COG1612	heme a metabolic process
MALG_RS07810	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MALG_RS07825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MALG_RS07830	COG5425	PFAM Usg family protein
MALG_RS07850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MALG_RS07855	COG0697	spore germination
MALG_RS07885	COG4536	flavin adenine dinucleotide binding
MALG_RS07890	COG4974	Belongs to the 'phage' integrase family
MALG_RS07900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MALG_RS07905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MALG_RS07915	COG5012	cobalamin binding
MALG_RS07925	COG0646	methionine synthase
MALG_RS07925	COG1410	methionine synthase
MALG_RS07935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MALG_RS07940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MALG_RS07945	COG0047	phosphoribosylformylglycinamidine synthase activity
MALG_RS07960	COG0512	Glutamine amidotransferase of anthranilate synthase
MALG_RS07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MALG_RS07975	COG0010	Belongs to the arginase family
MALG_RS08135	COG3023	N-Acetylmuramoyl-L-alanine amidase
MALG_RS08170	COG3328	transposase activity
MALG_RS08215	COG5507	3-demethylubiquinone-9 3-methyltransferase
MALG_RS08240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MALG_RS08240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS08250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS08255	COG1802	Transcriptional regulator
MALG_RS08300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS08325	COG4191	Histidine kinase
MALG_RS08330	COG0251	oxidation-reduction process
MALG_RS08340	COG4215	(ABC) transporter
MALG_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MALG_RS08360	COG3383	formate dehydrogenase (NAD+) activity
MALG_RS08380	COG3328	transposase activity
MALG_RS08400	COG3328	transposase activity
MALG_RS08500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MALG_RS08505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MALG_RS08510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MALG_RS08520	COG2166	iron-sulfur cluster assembly
MALG_RS08525	COG0629	single-stranded DNA binding
MALG_RS08530	COG0741	lytic transglycosylase activity
MALG_RS08530	COG1196	nuclear chromosome segregation
MALG_RS08530	COG0739	heme binding
MALG_RS08545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MALG_RS08560	COG0233	cytoplasmic translational termination
MALG_RS08565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MALG_RS08575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MALG_RS08580	COG0750	zinc metalloprotease
MALG_RS08585	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MALG_RS08595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MALG_RS08600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MALG_RS08610	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MALG_RS08620	COG0433	COG0433 Predicted ATPase
MALG_RS08650	COG2133	pyrroloquinoline quinone binding
MALG_RS08665	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MALG_RS08675	COG1561	YicC-like family, N-terminal region
MALG_RS08680	COG0194	GDP metabolic process
MALG_RS08690	COG0626	cystathionine gamma-synthase activity
MALG_RS08695	COG5002	protein histidine kinase activity
MALG_RS08705	COG0573	inorganic phosphate transmembrane transporter activity
MALG_RS08710	COG0581	inorganic phosphate transmembrane transporter activity
MALG_RS08715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MALG_RS08725	COG0745	RESPONSE REGULATOR receiver
MALG_RS08730	COG1960	acyl-CoA dehydrogenase activity
MALG_RS08740	COG0129	dihydroxy-acid dehydratase activity
MALG_RS08745	COG2197	response regulator
MALG_RS08750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MALG_RS08755	COG0052	Belongs to the universal ribosomal protein uS2 family
MALG_RS08760	COG3842	ATPase activity
MALG_RS08765	COG0366	Alpha amylase catalytic
MALG_RS08770	COG0395	ABC-type sugar transport system, permease component
MALG_RS08775	COG1175	transmembrane transport
MALG_RS08780	COG1653	transport
MALG_RS08785	COG1609	Transcriptional regulator
MALG_RS08800	COG0243	molybdopterin cofactor binding
MALG_RS08805	COG0437	4 iron, 4 sulfur cluster binding
MALG_RS08810	COG3302	dmso reductase anchor subunit
MALG_RS08815	COG4608	Belongs to the ABC transporter superfamily
MALG_RS08820	COG0444	Belongs to the ABC transporter superfamily
MALG_RS08830	COG0601	transmembrane transport
MALG_RS08845	COG0747	negative chemotaxis
MALG_RS08875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MALG_RS08900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MALG_RS08960	COG1475	DNA binding
MALG_RS08975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MALG_RS08985	COG3328	transposase activity
MALG_RS08995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MALG_RS09010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MALG_RS09015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MALG_RS09015	COG3264	Mechanosensitive ion channel
MALG_RS09025	COG0494	nUDIX hydrolase
MALG_RS09035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MALG_RS09040	COG0415	Belongs to the DNA photolyase family
MALG_RS09065	COG1960	acyl-CoA dehydrogenase activity
MALG_RS09075	COG1024	Enoyl-CoA hydratase
MALG_RS09080	COG3246	L-lysine catabolic process to acetate
MALG_RS09085	COG0824	Thioesterase
MALG_RS09085	COG1250	3-hydroxyacyl-CoA dehydrogenase
MALG_RS09090	COG2358	TRAP transporter, solute receptor (TAXI family
MALG_RS09120	COG0601	transmembrane transport
MALG_RS09125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS09130	COG0444	Belongs to the ABC transporter superfamily
MALG_RS09135	COG4608	Belongs to the ABC transporter superfamily
MALG_RS09145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MALG_RS09165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MALG_RS09175	COG0123	including yeast histone deacetylase and acetoin utilization protein
MALG_RS09185	COG0488	(ABC) transporter
MALG_RS09205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MALG_RS09210	COG0416	fatty acid biosynthetic process
MALG_RS09215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MALG_RS09220	COG0776	regulation of translation
MALG_RS09235	COG0717	Belongs to the dCTP deaminase family
MALG_RS09245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MALG_RS09250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MALG_RS09255	COG1472	Belongs to the glycosyl hydrolase 3 family
MALG_RS09265	COG0018	arginyl-trna synthetase
MALG_RS09270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MALG_RS09275	COG0316	Belongs to the HesB IscA family
MALG_RS09300	COG1522	sequence-specific DNA binding
MALG_RS09300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MALG_RS09305	COG2313	pseudouridylate synthase activity
MALG_RS09325	COG0114	fumarate hydratase activity
MALG_RS09340	COG4106	trans-aconitate 2-methyltransferase activity
MALG_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS09355	COG4166	transmembrane transport
MALG_RS09380	COG0538	isocitrate dehydrogenase activity
MALG_RS09385	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MALG_RS09400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MALG_RS09415	COG1024	Enoyl-CoA hydratase
MALG_RS09430	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MALG_RS09435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MALG_RS09440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MALG_RS09455	COG0583	DNA-binding transcription factor activity
MALG_RS09460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MALG_RS09480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MALG_RS09495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MALG_RS09505	COG2354	Protein conserved in bacteria
MALG_RS09530	COG0405	Gamma-glutamyltransferase
MALG_RS09545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MALG_RS09555	COG0583	DNA-binding transcription factor activity
MALG_RS09570	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MALG_RS09580	COG1960	acyl-CoA dehydrogenase activity
MALG_RS09600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MALG_RS09610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MALG_RS09620	COG0542	response to heat
MALG_RS09650	COG2124	cytochrome p450
MALG_RS09655	COG0058	SHG alpha-glucan phosphorylase activity
MALG_RS09660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MALG_RS09665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MALG_RS09670	COG0297	glycogen (starch) synthase activity
MALG_RS09685	COG0033	Phosphoglucomutase
MALG_RS09690	COG0667	Aldo Keto reductase
MALG_RS09695	COG0823	Involved in the tonB-independent uptake of proteins
MALG_RS09700	COG0513	Belongs to the DEAD box helicase family
MALG_RS09710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS09720	COG0583	DNA-binding transcription factor activity
MALG_RS09730	COG2267	carboxylic ester hydrolase activity
MALG_RS09735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MALG_RS09740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MALG_RS09745	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS09755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MALG_RS09760	COG3622	Belongs to the hyi family
MALG_RS09775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MALG_RS09790	COG3239	Fatty acid desaturase
MALG_RS09795	COG0343	queuine tRNA-ribosyltransferase activity
MALG_RS09800	COG0189	ligase activity
MALG_RS09800	COG4067	protein conserved in archaea
MALG_RS09815	COG2151	metal-sulfur cluster biosynthetic enzyme
MALG_RS09830	COG0006	proline dipeptidase activity
MALG_RS09840	COG0149	triose-phosphate isomerase activity
MALG_RS09845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS09850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MALG_RS09855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS09885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MALG_RS09890	COG0129	dihydroxy-acid dehydratase activity
MALG_RS09895	COG0800	Aldolase
MALG_RS09925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MALG_RS09940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MALG_RS09950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MALG_RS09955	COG0028	Belongs to the TPP enzyme family
MALG_RS09960	COG0440	acetolactate synthase activity
MALG_RS09985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MALG_RS09990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MALG_RS09995	COG0134	indole-3-glycerol-phosphate synthase activity
MALG_RS10000	COG0315	cyclic pyranopterin monophosphate synthase activity
MALG_RS10005	COG0303	'Molybdopterin
MALG_RS10010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MALG_RS10015	COG0658	competence protein
MALG_RS10015	COG2333	competence protein COMEC
MALG_RS10020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MALG_RS10025	COG0372	Belongs to the citrate synthase family
MALG_RS10030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MALG_RS10045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MALG_RS10050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MALG_RS10055	COG0435	Glutathione S-transferase
MALG_RS10080	COG0697	spore germination
MALG_RS10105	COG0697	spore germination
MALG_RS10110	COG0148	phosphopyruvate hydratase activity
MALG_RS10130	COG0166	Belongs to the GPI family
MALG_RS10140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MALG_RS10165	COG0126	phosphoglycerate kinase activity
MALG_RS10175	COG3588	fructose-bisphosphate aldolase
MALG_RS10180	COG0642	Histidine kinase
MALG_RS10200	COG2828	Protein conserved in bacteria
MALG_RS10210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MALG_RS10215	COG1802	Transcriptional regulator
MALG_RS10220	COG1053	succinate dehydrogenase
MALG_RS10235	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MALG_RS10240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MALG_RS10250	COG0022	dehydrogenase e1 component
MALG_RS10250	COG0508	dehydrogenase complex catalyzes the overall conversion of
MALG_RS10260	COG0508	dehydrogenase complex catalyzes the overall conversion of
MALG_RS10265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MALG_RS10285	COG1175	transmembrane transport
MALG_RS10290	COG0395	ABC-type sugar transport system, permease component
MALG_RS10300	COG0129	dihydroxy-acid dehydratase activity
MALG_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS10310	COG3734	2-keto-3-deoxy-galactonokinase
MALG_RS10315	COG0800	Aldolase
MALG_RS10405	COG4695	Portal protein
MALG_RS10415	COG0583	DNA-binding transcription factor activity
MALG_RS10425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MALG_RS10430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MALG_RS10435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MALG_RS10445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MALG_RS10455	COG0360	Binds together with S18 to 16S ribosomal RNA
MALG_RS10460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MALG_RS10465	COG0359	binds to the 23S rRNA
MALG_RS10480	COG0544	peptidyl-prolyl cis-trans isomerase activity
MALG_RS10495	COG1802	Transcriptional regulator
MALG_RS10515	COG1653	transport
MALG_RS10520	COG0395	ABC-type sugar transport system, permease component
MALG_RS10525	COG4209	transmembrane transport
MALG_RS10530	COG3842	ATPase activity
MALG_RS10535	COG1802	Transcriptional regulator
MALG_RS10550	COG0321	lipoyl(octanoyl) transferase activity
MALG_RS10575	COG1610	YqeY-like protein
MALG_RS10580	COG0505	Belongs to the CarA family
MALG_RS10590	COG1802	Transcriptional regulator
MALG_RS10600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MALG_RS10610	COG1404	Belongs to the peptidase S8 family
MALG_RS10615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MALG_RS10625	COG1522	sequence-specific DNA binding
MALG_RS10635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MALG_RS10640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MALG_RS10645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MALG_RS10650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MALG_RS10660	COG0574	Belongs to the PEP-utilizing enzyme family
MALG_RS10660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MALG_RS10665	COG0751	glycine-tRNA ligase activity
MALG_RS10675	COG0752	glycyl-tRNA synthetase alpha subunit
MALG_RS10695	COG0587	DNA-directed DNA polymerase activity
MALG_RS10715	COG0330	HflC and HflK could
MALG_RS10730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MALG_RS10735	COG1760	l-serine dehydratase
MALG_RS10760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MALG_RS10775	COG0504	CTP synthase activity
MALG_RS10780	COG0737	Belongs to the 5'-nucleotidase family
MALG_RS10805	COG4215	(ABC) transporter
MALG_RS10810	COG4160	amino acid transport
MALG_RS10815	COG0174	glutamine synthetase
MALG_RS10820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MALG_RS10820	COG0519	Catalyzes the synthesis of GMP from XMP
MALG_RS10825	COG0174	glutamine synthetase
MALG_RS10830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS10835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MALG_RS10855	COG3243	poly(R)-hydroxyalkanoic acid synthase
MALG_RS10880	COG0564	pseudouridine synthase activity
MALG_RS10940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MALG_RS10945	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MALG_RS10965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MALG_RS10970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MALG_RS10975	COG3718	enzyme involved in inositol metabolism
MALG_RS10980	COG1082	Xylose isomerase domain protein TIM barrel
MALG_RS10985	COG3962	Belongs to the TPP enzyme family
MALG_RS10995	COG0673	inositol 2-dehydrogenase activity
MALG_RS11000	COG1609	Transcriptional regulator
MALG_RS11005	COG0604	alcohol dehydrogenase
MALG_RS11020	COG1228	amidohydrolase
MALG_RS11030	COG0625	glutathione transferase activity
MALG_RS11035	COG2873	o-acetylhomoserine
MALG_RS11060	COG4235	cytochrome complex assembly
MALG_RS11065	COG3088	subunit of a heme lyase
MALG_RS11070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MALG_RS11075	COG1138	Cytochrome C-type biogenesis protein
MALG_RS11130	COG2205	protein histidine kinase activity
MALG_RS11130	COG0784	Response regulator, receiver
MALG_RS11130	COG2198	Histidine kinase
MALG_RS11155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MALG_RS11160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MALG_RS11165	COG0583	DNA-binding transcription factor activity
MALG_RS11185	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MALG_RS11200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MALG_RS11215	COG0175	sulfate reduction
MALG_RS11220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MALG_RS11230	COG1648	precorrin-2 dehydrogenase activity
MALG_RS11230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MALG_RS11235	COG1522	sequence-specific DNA binding
MALG_RS11280	COG0418	dihydroorotase activity
MALG_RS11285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MALG_RS11290	COG0305	Participates in initiation and elongation during chromosome replication
MALG_RS11295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MALG_RS11300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MALG_RS11305	COG1127	ABC transporter
MALG_RS11335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MALG_RS11350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MALG_RS11355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MALG_RS11360	COG0739	heme binding
MALG_RS11360	COG0741	lytic transglycosylase activity
MALG_RS11360	COG1196	nuclear chromosome segregation
MALG_RS11370	COG0805	protein transport
MALG_RS11375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MALG_RS11380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MALG_RS11385	COG2378	regulation of single-species biofilm formation
MALG_RS11390	COG0513	Belongs to the DEAD box helicase family
MALG_RS11395	COG3842	ATPase activity
MALG_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS11420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MALG_RS11435	COG0513	Belongs to the DEAD box helicase family
MALG_RS11440	COG1764	response to oxidative stress
MALG_RS11450	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MALG_RS11460	COG1007	ATP synthesis coupled electron transport
MALG_RS11475	COG0713	ATP synthesis coupled electron transport
MALG_RS11490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MALG_RS11500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MALG_RS11555	COG0649	NAD binding
MALG_RS11565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MALG_RS11570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MALG_RS11600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MALG_RS11620	COG1960	acyl-CoA dehydrogenase activity
MALG_RS11640	COG0546	phosphoglycolate phosphatase activity
MALG_RS11645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MALG_RS11650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MALG_RS11670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MALG_RS11685	COG1162	GTPase activity
MALG_RS11690	COG1473	amidohydrolase
MALG_RS11695	COG4172	Belongs to the ABC transporter superfamily
MALG_RS11700	COG0747	negative chemotaxis
MALG_RS11705	COG0601	transmembrane transport
MALG_RS11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS11725	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MALG_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS11740	COG0204	Acyl-transferase
MALG_RS11745	COG0308	aminopeptidase N
MALG_RS11755	COG3750	Belongs to the UPF0335 family
MALG_RS11790	COG5002	protein histidine kinase activity
MALG_RS11800	COG0745	RESPONSE REGULATOR receiver
MALG_RS11805	COG3800	Transcriptional regulator
MALG_RS11805	COG1396	sequence-specific DNA binding
MALG_RS11830	COG0410	ABC transporter
MALG_RS11845	COG0439	Biotin carboxylase
MALG_RS11850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MALG_RS11870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MALG_RS11875	COG0740	serine-type endopeptidase activity
MALG_RS11905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MALG_RS11905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MALG_RS11975	COG4397	Mu-like prophage major head subunit gpT
MALG_RS12005	COG4383	Mu-like prophage protein gp29
MALG_RS12010	COG4373	Mu-like prophage FluMu protein gp28
MALG_RS12140	COG3328	transposase activity
MALG_RS12225	COG0432	Pfam Uncharacterised protein family UPF0047
MALG_RS12250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MALG_RS12275	COG1741	Belongs to the pirin family
MALG_RS12290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MALG_RS12295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MALG_RS12300	COG0101	tRNA pseudouridine synthase activity
MALG_RS12305	COG3106	COG3106 Predicted ATPase
MALG_RS12315	COG3768	UPF0283 membrane protein
MALG_RS12320	COG0438	transferase activity, transferring glycosyl groups
MALG_RS12325	COG0534	Mate efflux family protein
MALG_RS12350	COG1960	acyl-CoA dehydrogenase activity
MALG_RS12360	COG0625	glutathione transferase activity
MALG_RS12365	COG0183	Belongs to the thiolase family
MALG_RS12370	COG1250	3-hydroxyacyl-CoA dehydrogenase
MALG_RS12370	COG1024	Enoyl-CoA hydratase
MALG_RS12375	COG5002	protein histidine kinase activity
MALG_RS12375	COG2176	DNA-directed DNA polymerase activity
MALG_RS12380	COG0745	RESPONSE REGULATOR receiver
MALG_RS12395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MALG_RS12405	COG0563	adenylate kinase activity
MALG_RS12410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MALG_RS12425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MALG_RS12430	COG0625	glutathione transferase activity
MALG_RS12435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MALG_RS12440	COG0077	Prephenate dehydratase
MALG_RS12445	COG3474	cytochrome
MALG_RS12450	COG4166	transmembrane transport
MALG_RS12455	COG4174	ABC transporter (Permease)
MALG_RS12460	COG4239	(ABC) transporter, permease
MALG_RS12465	COG4172	Belongs to the ABC transporter superfamily
MALG_RS12470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MALG_RS12475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MALG_RS12485	COG2017	converts alpha-aldose to the beta-anomer
MALG_RS12495	COG2801	Transposase and inactivated derivatives
MALG_RS12500	COG3328	transposase activity
MALG_RS12515	COG3328	transposase activity
MALG_RS12575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MALG_RS12590	COG0110	maltose O-acetyltransferase activity
MALG_RS12625	COG0297	glycogen (starch) synthase activity
MALG_RS12630	COG2192	nodulation
MALG_RS12645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MALG_RS12675	COG3550	peptidyl-serine autophosphorylation
MALG_RS12710	COG3328	transposase activity
MALG_RS12735	COG2186	Transcriptional regulator
MALG_RS12755	COG4948	Mandelate Racemase Muconate Lactonizing
MALG_RS12760	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS12765	COG3119	arylsulfatase activity
MALG_RS12775	COG2186	Transcriptional regulator
MALG_RS12780	COG0012	GTP binding
MALG_RS12785	COG0159	tryptophan synthase activity
MALG_RS12790	COG0784	Response regulator, receiver
MALG_RS12790	COG2205	protein histidine kinase activity
MALG_RS12815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MALG_RS12820	COG0193	aminoacyl-tRNA hydrolase activity
MALG_RS12830	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS12835	COG1132	(ABC) transporter
MALG_RS12845	COG2135	peptidase activity
MALG_RS12860	COG0737	Belongs to the 5'-nucleotidase family
MALG_RS12875	COG1686	Belongs to the peptidase S11 family
MALG_RS12880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MALG_RS12885	COG2813	Specifically methylates the guanine in position
MALG_RS12890	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS12895	COG0408	coproporphyrinogen oxidase activity
MALG_RS12905	COG0590	tRNA wobble adenosine to inosine editing
MALG_RS12910	COG1187	pseudouridine synthase activity
MALG_RS12915	COG0861	Integral membrane protein TerC family
MALG_RS12930	COG3853	Toxic anion resistance protein (TelA)
MALG_RS12965	COG1490	D-aminoacyl-tRNA deacylase activity
MALG_RS12995	COG3246	L-lysine catabolic process to acetate
MALG_RS13025	COG1250	3-hydroxyacyl-CoA dehydrogenase
MALG_RS13040	COG1234	tRNA 3'-trailer cleavage
MALG_RS13055	COG0697	spore germination
MALG_RS13065	COG0655	NAD(P)H dehydrogenase (quinone) activity
MALG_RS13090	COG0667	Aldo Keto reductase
MALG_RS13125	COG0556	nucleotide-excision repair
MALG_RS13155	COG2832	Protein of unknown function (DUF454)
MALG_RS13190	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MALG_RS13205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MALG_RS13220	COG1943	Transposase
MALG_RS13260	COG0644	oxidoreductase
MALG_RS13265	COG1278	Cold shock
MALG_RS13275	COG1136	(ABC) transporter
MALG_RS13285	COG0483	inositol monophosphate 1-phosphatase activity
MALG_RS13290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MALG_RS13290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MALG_RS13295	COG0509	glycine decarboxylation via glycine cleavage system
MALG_RS13300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MALG_RS13305	COG1959	2 iron, 2 sulfur cluster binding
MALG_RS13320	COG1435	thymidine kinase activity
MALG_RS13340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MALG_RS13355	COG0604	alcohol dehydrogenase
MALG_RS13360	COG2937	Belongs to the GPAT DAPAT family
MALG_RS13365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MALG_RS13365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MALG_RS13370	COG5001	Diguanylate cyclase
MALG_RS13370	COG3300	MHYT domain
MALG_RS13375	COG0813	purine-nucleoside phosphorylase activity
MALG_RS13400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MALG_RS13410	COG0019	diaminopimelate decarboxylase activity
MALG_RS13455	COG2030	dehydratase
MALG_RS13485	COG0039	L-malate dehydrogenase activity
MALG_RS13490	COG0045	succinate-CoA ligase (ADP-forming) activity
MALG_RS13500	COG0567	Dehydrogenase, E1 component
MALG_RS13505	COG0508	dehydrogenase complex catalyzes the overall conversion of
MALG_RS13535	COG2884	Cell division ATP-binding protein ftsE
MALG_RS13550	COG0019	diaminopimelate decarboxylase activity
MALG_RS13570	COG0165	Argininosuccinate lyase
MALG_RS13575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MALG_RS13595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MALG_RS13615	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MALG_RS13625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MALG_RS13680	COG1573	uracil-dna glycosylase
MALG_RS13690	COG1227	inorganic diphosphatase activity
MALG_RS13705	COG0287	Prephenate dehydrogenase
MALG_RS13710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MALG_RS13715	COG5310	Homospermidine synthase
MALG_RS13720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MALG_RS13725	COG2818	Glycosylase
MALG_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS13745	COG2264	protein methyltransferase activity
MALG_RS13755	COG0142	geranyltranstransferase activity
MALG_RS13760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MALG_RS13775	COG1522	sequence-specific DNA binding
MALG_RS13800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MALG_RS13805	COG0746	molybdenum cofactor guanylyltransferase activity
MALG_RS13810	COG0303	'Molybdopterin
MALG_RS13825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MALG_RS13835	COG0009	L-threonylcarbamoyladenylate synthase
MALG_RS13840	COG1960	acyl-CoA dehydrogenase activity
MALG_RS13845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MALG_RS13885	COG2264	protein methyltransferase activity
MALG_RS13895	COG5457	Domain of unknown function (DUF1127)
MALG_RS13900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MALG_RS13905	COG0632	four-way junction helicase activity
MALG_RS13910	COG2255	four-way junction helicase activity
MALG_RS13915	COG2723	6-phospho-beta-galactosidase activity
MALG_RS13930	COG4974	Belongs to the 'phage' integrase family
MALG_RS13945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS13950	COG1183	phosphatidylcholine synthase activity
MALG_RS13965	COG1228	amidohydrolase
MALG_RS13970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MALG_RS13975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MALG_RS13990	COG0071	Belongs to the small heat shock protein (HSP20) family
MALG_RS14000	COG0529	Catalyzes the synthesis of activated sulfate
MALG_RS14000	COG2046	Belongs to the sulfate adenylyltransferase family
MALG_RS14005	COG0583	DNA-binding transcription factor activity
MALG_RS14015	COG0492	ferredoxin-NADP+ reductase activity
MALG_RS14020	COG1522	sequence-specific DNA binding
MALG_RS14035	COG0564	pseudouridine synthase activity
MALG_RS14045	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MALG_RS14050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MALG_RS14055	COG0517	IMP dehydrogenase activity
MALG_RS14055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MALG_RS14060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MALG_RS14070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MALG_RS14100	COG1956	GAF domain-containing protein
MALG_RS14105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MALG_RS14110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MALG_RS14115	COG1253	flavin adenine dinucleotide binding
MALG_RS14120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MALG_RS14125	COG1702	phosphate starvation-inducible protein PhoH
MALG_RS14135	COG2885	chlorophyll binding
MALG_RS14145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MALG_RS14160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MALG_RS14165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MALG_RS14175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MALG_RS14180	COG0735	belongs to the Fur family
MALG_RS14200	COG1522	sequence-specific DNA binding
MALG_RS14220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MALG_RS14230	COG1136	(ABC) transporter
MALG_RS14240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MALG_RS14250	COG1132	(ABC) transporter
MALG_RS14260	COG0354	folic acid binding
MALG_RS14270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MALG_RS14290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MALG_RS14300	COG1250	3-hydroxyacyl-CoA dehydrogenase
MALG_RS14310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MALG_RS14320	COG1660	Displays ATPase and GTPase activities
MALG_RS14330	COG2205	protein histidine kinase activity
MALG_RS14335	COG0745	RESPONSE REGULATOR receiver
MALG_RS14340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MALG_RS14365	COG5002	protein histidine kinase activity
MALG_RS14370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MALG_RS14380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MALG_RS14385	COG0594	ribonuclease P activity
MALG_RS14390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MALG_RS14415	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MALG_RS14425	COG0179	Fumarylacetoacetate (FAA) hydrolase
MALG_RS14435	COG2030	dehydratase
MALG_RS14440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MALG_RS14445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MALG_RS14450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MALG_RS14455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MALG_RS14460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MALG_RS14470	COG0089	rRNA binding
MALG_RS14475	COG0088	Forms part of the polypeptide exit tunnel
MALG_RS14480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MALG_RS14485	COG0051	transcription antitermination factor activity, RNA binding
MALG_RS14495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MALG_RS14505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MALG_RS14520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MALG_RS14525	COG0085	RNA polymerase activity
MALG_RS14535	COG0222	ribosome binding
MALG_RS14540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MALG_RS14550	COG0784	Response regulator, receiver
MALG_RS14550	COG2205	protein histidine kinase activity
MALG_RS14550	COG5002	protein histidine kinase activity
MALG_RS14560	COG0081	regulation of translation
MALG_RS14565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MALG_RS14570	COG0250	Participates in transcription elongation, termination and antitermination
MALG_RS14580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MALG_RS14590	COG1215	transferase activity, transferring glycosyl groups
MALG_RS14615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MALG_RS14625	COG1063	alcohol dehydrogenase
MALG_RS14640	COG0135	phosphoribosylanthranilate isomerase activity
MALG_RS14650	COG0776	regulation of translation
MALG_RS14655	COG0539	negative regulation of cytoplasmic translation
MALG_RS14665	COG0667	Aldo Keto reductase
MALG_RS14670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MALG_RS14675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MALG_RS14680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MALG_RS14690	COG0183	Belongs to the thiolase family
MALG_RS14695	COG1366	Belongs to the anti-sigma-factor antagonist family
MALG_RS14705	COG0405	Gamma-glutamyltransferase
MALG_RS14725	COG1063	alcohol dehydrogenase
MALG_RS14745	COG4948	Mandelate Racemase Muconate Lactonizing
MALG_RS14755	COG2301	Belongs to the HpcH HpaI aldolase family
MALG_RS14770	COG0825	malonyl-CoA metabolic process
MALG_RS14775	COG1802	Transcriptional regulator
MALG_RS14795	COG0729	surface antigen
MALG_RS14805	COG0318	PFAM AMP-dependent synthetase and ligase
MALG_RS14810	COG0183	Belongs to the thiolase family
MALG_RS14815	COG0436	Aminotransferase
MALG_RS14880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MALG_RS14900	COG0339	signal peptide processing
MALG_RS14905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MALG_RS14910	COG0756	dUTP diphosphatase activity
MALG_RS14935	COG0606	chelatase, subunit chli
MALG_RS14950	COG0792	nuclease activity
MALG_RS14955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MALG_RS14965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MALG_RS14970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MALG_RS14975	COG4143	(ABC) transporter
MALG_RS14985	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MALG_RS15010	COG2808	Putative FMN-binding domain
MALG_RS15015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MALG_RS15020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MALG_RS15035	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MALG_RS15040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MALG_RS15050	COG0583	DNA-binding transcription factor activity
MALG_RS15055	COG1063	alcohol dehydrogenase
MALG_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
MALG_RS15085	COG2186	Transcriptional regulator
MALG_RS15110	COG0473	3-isopropylmalate dehydrogenase activity
MALG_RS15130	COG0066	3-isopropylmalate dehydratase activity
MALG_RS15135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MALG_RS15140	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MALG_RS15140	COG3264	Mechanosensitive ion channel
MALG_RS15145	COG0799	negative regulation of ribosome biogenesis
MALG_RS15150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MALG_RS15155	COG0742	ribosomal rna small subunit methyltransferase
MALG_RS15165	COG0678	peroxiredoxin activity
MALG_RS15170	COG2154	pterin-4-alpha-carbinolamine dehydratase
MALG_RS15200	COG2853	Lipoprotein
MALG_RS15210	COG0300	oxidoreductase activity
MALG_RS15225	COG1595	DNA-templated transcription, initiation
MALG_RS15230	COG3806	Anti-sigma factor
MALG_RS15240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MALG_RS15245	COG0004	ammonium transporteR
MALG_RS15250	COG0347	Belongs to the P(II) protein family
MALG_RS15265	COG2897	thiosulfate sulfurtransferase activity
MALG_RS15270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MALG_RS15295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MALG_RS15300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MALG_RS15305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MALG_RS15335	COG0791	NLP P60 protein
MALG_RS15340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MALG_RS15350	COG0288	reversible hydration of carbon dioxide
MALG_RS15360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MALG_RS15390	COG2816	NAD+ diphosphatase activity
MALG_RS15400	COG0563	adenylate kinase activity
MALG_RS15405	COG2096	Adenosyltransferase
MALG_RS15415	COG0300	oxidoreductase activity
MALG_RS15430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MALG_RS15445	COG2326	polyphosphate kinase activity
MALG_RS15450	COG1522	sequence-specific DNA binding
MALG_RS15455	COG0686	Belongs to the AlaDH PNT family
MALG_RS15460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MALG_RS15460	COG0072	phenylalanine-tRNA ligase activity
MALG_RS15465	COG2124	cytochrome p450
MALG_RS15475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MALG_RS15480	COG1024	Enoyl-CoA hydratase
MALG_RS15500	COG0312	modulator of DNA gyrase
MALG_RS15510	COG1832	CoA-binding protein
MALG_RS15535	COG2171	N-acyltransferase activity
MALG_RS15555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MALG_RS15575	COG0557	exoribonuclease II activity
MALG_RS15585	COG0443	Heat shock 70 kDa protein
MALG_RS15595	COG2003	Belongs to the UPF0758 family
MALG_RS15600	COG2951	lytic endotransglycosylase activity
MALG_RS15625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MALG_RS15650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MALG_RS15655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MALG_RS15660	COG1137	ATPase activity
MALG_RS15675	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MALG_RS15690	COG1970	mechanosensitive ion channel activity
MALG_RS15700	COG0314	molybdopterin synthase activity
MALG_RS15710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MALG_RS15725	COG1381	Involved in DNA repair and RecF pathway recombination
MALG_RS15735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MALG_RS15745	COG0571	ribonuclease III activity
MALG_RS15750	COG0681	Belongs to the peptidase S26 family
MALG_RS15755	COG3119	arylsulfatase activity
MALG_RS15760	COG0736	holo-[acyl-carrier-protein] synthase activity
MALG_RS15765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MALG_RS15775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MALG_RS15780	COG1758	RNA polymerase activity
MALG_RS15785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MALG_RS15795	COG1238	metal cluster binding
MALG_RS15805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MALG_RS15810	COG0328	RNA-DNA hybrid ribonuclease activity
MALG_RS15815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MALG_RS15835	COG1968	undecaprenyl-diphosphatase activity
MALG_RS15845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MALG_RS15850	COG0640	Transcriptional regulator
MALG_RS15865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MALG_RS15890	COG0346	lactoylglutathione lyase activity
MALG_RS15905	COG2885	chlorophyll binding
MALG_RS15935	COG0431	NADPH-dependent FMN reductase
MALG_RS15940	COG2885	chlorophyll binding
MALG_RS15950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MALG_RS15955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MALG_RS15975	COG0583	DNA-binding transcription factor activity
MALG_RS15980	COG0693	protein deglycase activity
MALG_RS15985	COG0446	pyridine nucleotide-disulphide oxidoreductase
MALG_RS15985	COG1902	pentaerythritol trinitrate reductase activity
MALG_RS16005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MALG_RS16010	COG0285	dihydrofolate synthase activity
MALG_RS16020	COG2835	tetraacyldisaccharide 4'-kinase activity
MALG_RS16030	COG3118	belongs to the thioredoxin family
MALG_RS16045	COG1177	transmembrane transport
MALG_RS16060	COG3842	ATPase activity
MALG_RS16065	COG0006	proline dipeptidase activity
MALG_RS16100	COG3842	ATPase activity
MALG_RS16110	COG1176	ABC-type spermidine putrescine transport system, permease component I
MALG_RS16115	COG1177	transmembrane transport
MALG_RS16120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS16170	COG0372	Belongs to the citrate synthase family
MALG_RS16175	COG0280	phosphate acetyltransferase
MALG_RS16180	COG0028	Belongs to the TPP enzyme family
MALG_RS16195	COG0438	transferase activity, transferring glycosyl groups
MALG_RS16230	COG0697	spore germination
MALG_RS16245	COG0776	regulation of translation
MALG_RS16250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MALG_RS16280	COG1058	Belongs to the CinA family
MALG_RS16280	COG1546	Belongs to the CinA family
MALG_RS16285	COG1489	DNA binding
MALG_RS16295	COG0024	Methionine aminopeptidase
MALG_RS16310	COG0793	Belongs to the peptidase S41A family
MALG_RS16315	COG1051	belongs to the nudix hydrolase family
MALG_RS16335	COG0745	RESPONSE REGULATOR receiver
MALG_RS16340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MALG_RS16345	COG1846	Transcriptional regulator
MALG_RS16350	COG0745	RESPONSE REGULATOR receiver
MALG_RS16355	COG0123	including yeast histone deacetylase and acetoin utilization protein
MALG_RS16360	COG1722	exodeoxyribonuclease VII activity
MALG_RS16365	COG0142	geranyltranstransferase activity
MALG_RS16370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MALG_RS16405	COG0489	protein tyrosine kinase activity
MALG_RS16450	COG0642	Histidine kinase
MALG_RS16480	COG3328	transposase activity
MALG_RS16490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MALG_RS16495	COG0022	dehydrogenase e1 component
MALG_RS16505	COG0508	dehydrogenase complex catalyzes the overall conversion of
MALG_RS16525	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MALG_RS16540	COG3284	Transcriptional regulator
MALG_RS16555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MALG_RS16565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MALG_RS16575	COG0124	histidyl-tRNA synthetase
MALG_RS16635	COG2066	Belongs to the glutaminase family
MALG_RS16645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MALG_RS16655	COG3845	ABC transporter
MALG_RS16660	COG4603	Belongs to the binding-protein-dependent transport system permease family
MALG_RS16665	COG1079	Belongs to the binding-protein-dependent transport system permease family
MALG_RS16685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MALG_RS16695	COG2860	membrane
MALG_RS16705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MALG_RS16705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MALG_RS16710	COG0697	spore germination
MALG_RS16720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MALG_RS16725	COG0612	Peptidase, M16
MALG_RS16730	COG0612	Peptidase, M16
MALG_RS16740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MALG_RS16745	COG0138	bifunctional purine biosynthesis protein purh
MALG_RS16765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MALG_RS16770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MALG_RS16775	COG3698	Phosphodiester glycosidase
MALG_RS16785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MALG_RS16800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MALG_RS16810	COG1185	polyribonucleotide nucleotidyltransferase activity
MALG_RS16825	COG0450	alkyl hydroperoxide reductase
MALG_RS16835	COG0006	proline dipeptidase activity
MALG_RS16840	COG4172	Belongs to the ABC transporter superfamily
MALG_RS16845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS16850	COG0601	transmembrane transport
MALG_RS16855	COG0747	negative chemotaxis
MALG_RS16880	COG0779	Required for maturation of 30S ribosomal subunits
MALG_RS16895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MALG_RS16900	COG0494	nUDIX hydrolase
MALG_RS16905	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MALG_RS16910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MALG_RS16915	COG0653	protein targeting
MALG_RS16930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MALG_RS16940	COG1012	belongs to the aldehyde dehydrogenase family
MALG_RS16945	COG1063	alcohol dehydrogenase
MALG_RS16960	COG1396	sequence-specific DNA binding
MALG_RS16965	COG0183	Belongs to the thiolase family
MALG_RS16970	COG4953	penicillin-binding protein 1C
MALG_RS16975	COG2373	Large extracellular alpha-helical protein
MALG_RS16985	COG3022	response to hydroperoxide
MALG_RS16990	COG0514	ATP-dependent DNA helicase (RecQ)
MALG_RS17010	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
MALG_RS17030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MALG_RS17035	COG1335	isochorismatase
MALG_RS17040	COG0443	Heat shock 70 kDa protein
MALG_RS17045	COG1054	Belongs to the UPF0176 family
MALG_RS17065	COG0446	pyridine nucleotide-disulphide oxidoreductase
MALG_RS17080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MALG_RS17085	COG0737	Belongs to the 5'-nucleotidase family
MALG_RS17090	COG3258	Cytochrome c
MALG_RS17115	COG0785	Cytochrome C biogenesis protein
MALG_RS17125	COG0640	Transcriptional regulator
MALG_RS17130	COG2391	methyltransferase activity
MALG_RS17155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MALG_RS17180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MALG_RS17190	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MALG_RS17195	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MALG_RS17200	COG1999	signal sequence binding
MALG_RS17215	COG0802	atpase or kinase
MALG_RS17225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MALG_RS17235	COG1074	ATP-dependent DNA helicase activity
MALG_RS17245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MALG_RS17255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MALG_RS17260	COG0747	negative chemotaxis
MALG_RS17270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MALG_RS17275	COG0601	transmembrane transport
MALG_RS17285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MALG_RS17295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MALG_RS17335	COG1131	(ABC) transporter
MALG_RS17355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MALG_RS17355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MALG_RS17365	COG0714	Associated with various cellular activities
MALG_RS17395	COG0277	FAD linked oxidase domain protein
MALG_RS17400	COG0277	FAD linked oxidase domain protein
MALG_RS17405	COG0247	lactate metabolic process
MALG_RS17410	COG3591	Belongs to the peptidase S1B family
MALG_RS17415	COG0071	Belongs to the small heat shock protein (HSP20) family
MALG_RS17425	COG1247	-acetyltransferase
MALG_RS17430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MALG_RS17435	COG3034	peptidoglycan biosynthetic process
MALG_RS17455	COG1132	(ABC) transporter
MALG_RS17460	COG1132	(ABC) transporter
MALG_RS17465	COG0617	tRNA 3'-terminal CCA addition
MALG_RS17470	COG0494	nUDIX hydrolase
MALG_RS17480	COG0494	nUDIX hydrolase
MALG_RS17495	COG2379	hydroxypyruvate reductase
MALG_RS17515	COG0137	argininosuccinate synthase activity
MALG_RS17525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MALG_RS17530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MALG_RS17530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MALG_RS17535	COG0280	phosphate acetyltransferase
MALG_RS17535	COG0281	malic enzyme
MALG_RS17540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MALG_RS17545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MALG_RS17555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MALG_RS17560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MALG_RS17565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MALG_RS17580	COG0357	Ribosomal RNA small subunit methyltransferase G
MALG_RS17585	COG0445	tRNA wobble uridine modification
MALG_RS17590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MALG_RS17595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MALG_RS17600	COG0424	maF-like protein
MALG_RS17605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MALG_RS17610	COG0237	dephospho-CoA kinase activity
MALG_RS17615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MALG_RS17620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MALG_RS17675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MALG_RS17680	COG1360	Flagellar Motor Protein
MALG_RS17700	COG1706	bacterial-type flagellum-dependent cell motility
MALG_RS17705	COG1338	Plays a role in the flagellum-specific transport system
MALG_RS17710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MALG_RS17720	COG1766	The M ring may be actively involved in energy transduction
MALG_RS17740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MALG_RS17750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MALG_RS17760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MALG_RS17775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MALG_RS17785	COG4786	Flagellar basal body rod
MALG_RS17790	COG4786	Flagellar basal body rod
MALG_RS17795	COG1987	bacterial-type flagellum assembly
MALG_RS17805	COG1558	bacterial-type flagellum-dependent cell motility
MALG_RS17810	COG1815	bacterial-type flagellum-dependent cell motility
MALG_RS17825	COG5443	negative regulation of bacterial-type flagellum assembly
MALG_RS17855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MALG_RS17865	COG2226	methyltransferase
MALG_RS17870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MALG_RS17880	COG0268	Binds directly to 16S ribosomal RNA
MALG_RS17890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MALG_RS18135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MALG_RS18300	COG1609	Transcriptional regulator
MALG_RS18460	COG1252	NADH dehydrogenase
MALG_RS18515	COG0587	DNA-directed DNA polymerase activity
MALG_RS18615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MALG_RS18850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MALG_RS18860	COG0277	FAD linked oxidase domain protein
MALG_RS19070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MALG_RS19230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MALG_RS19715	COG0587	DNA-directed DNA polymerase activity
MALG_RS19800	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MALG_RS20105	COG0747	negative chemotaxis
MALG_RS20470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MALG_RS20695	COG1022	Amp-dependent synthetase and ligase
MALG_RS20720	COG3383	formate dehydrogenase (NAD+) activity
MALG_RS20780	COG1953	Uracil, thiamine, allantoin
MALG_RS20825	COG0587	DNA-directed DNA polymerase activity
MALG_RS21040	COG0768	penicillin binding
MALG_RS21640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MALG_RS22220	COG3250	beta-galactosidase activity
MALG_RS22685	COG0747	negative chemotaxis
MALG_RS22690	COG0444	Belongs to the ABC transporter superfamily
MALG_RS22705	COG0601	transmembrane transport
MALG_RS23415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MALG_RS23540	COG0246	Mannitol dehydrogenase
MALG_RS23670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MALG_RS23945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MALG_RS24485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MALG_RS25000	COG1172	Belongs to the binding-protein-dependent transport system permease family
MALG_RS25020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MALG_RS25080	COG2226	methyltransferase