locus-tag	class	description
Ga0123461_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Ga0123461_RS00010	COG0592	DNA-directed DNA polymerase activity
Ga0123461_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ga0123461_RS00020	COG0187	DNA topoisomerase II activity
Ga0123461_RS00045	COG0494	nUDIX hydrolase
Ga0123461_RS00050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Ga0123461_RS00055	COG2226	methyltransferase
Ga0123461_RS00060	COG2267	carboxylic ester hydrolase activity
Ga0123461_RS00065	COG0156	8-amino-7-oxononanoate synthase activity
Ga0123461_RS00075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ga0123461_RS00080	COG0288	reversible hydration of carbon dioxide
Ga0123461_RS00090	COG0149	triose-phosphate isomerase activity
Ga0123461_RS00105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ga0123461_RS00125	COG1683	Conserved Protein
Ga0123461_RS00135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Ga0123461_RS00180	COG0612	Peptidase, M16
Ga0123461_RS00185	COG0612	Peptidase, M16
Ga0123461_RS00195	COG0138	bifunctional purine biosynthesis protein purh
Ga0123461_RS00205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Ga0123461_RS00210	COG0009	L-threonylcarbamoyladenylate synthase
Ga0123461_RS00215	COG1333	cytochrome c biogenesis protein
Ga0123461_RS00220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ga0123461_RS00225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Ga0123461_RS00230	COG1214	PFAM Peptidase M22, glycoprotease
Ga0123461_RS00235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ga0123461_RS00240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Ga0123461_RS00245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ga0123461_RS00290	COG2208	phosphoserine phosphatase activity
Ga0123461_RS00290	COG2770	Histidine kinase
Ga0123461_RS00295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ga0123461_RS00305	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ga0123461_RS00310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ga0123461_RS00325	COG0616	signal peptide processing
Ga0123461_RS00330	COG1968	undecaprenyl-diphosphatase activity
Ga0123461_RS00345	COG1366	Belongs to the anti-sigma-factor antagonist family
Ga0123461_RS00350	COG1366	Belongs to the anti-sigma-factor antagonist family
Ga0123461_RS00375	COG0708	Exodeoxyribonuclease III
Ga0123461_RS00380	COG1077	Cell shape determining protein MreB Mrl
Ga0123461_RS00395	COG0768	penicillin binding
Ga0123461_RS00400	COG0772	Belongs to the SEDS family
Ga0123461_RS00405	COG0730	response to heat
Ga0123461_RS00415	COG1024	Enoyl-CoA hydratase
Ga0123461_RS00440	COG2151	metal-sulfur cluster biosynthetic enzyme
Ga0123461_RS00445	COG0822	iron-sulfur transferase activity
Ga0123461_RS00450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ga0123461_RS00455	COG0719	Fe-S assembly protein
Ga0123461_RS00460	COG0396	ATPase activity
Ga0123461_RS00465	COG0719	Fe-S assembly protein
Ga0123461_RS00475	COG0784	Response regulator, receiver
Ga0123461_RS00475	COG0643	Histidine kinase
Ga0123461_RS00475	COG2198	Histidine kinase
Ga0123461_RS00485	COG0840	transmembrane signaling receptor activity
Ga0123461_RS00495	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS00500	COG2201	protein-glutamate methylesterase activity
Ga0123461_RS00515	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS00545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Ga0123461_RS00555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Ga0123461_RS00570	COG1580	Controls the rotational direction of flagella during chemotaxis
Ga0123461_RS00590	COG1338	Plays a role in the flagellum-specific transport system
Ga0123461_RS00605	COG2199	diguanylate cyclase activity
Ga0123461_RS00605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS00610	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS00635	COG1157	protein secretion by the type III secretion system
Ga0123461_RS00645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ga0123461_RS00650	COG1766	The M ring may be actively involved in energy transduction
Ga0123461_RS00655	COG1677	Flagellar hook-basal body complex protein FliE
Ga0123461_RS00665	COG1815	bacterial-type flagellum-dependent cell motility
Ga0123461_RS00670	COG2204	response regulator
Ga0123461_RS00690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Ga0123461_RS00710	COG1684	flagellar biosynthetic protein fliR
Ga0123461_RS00715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Ga0123461_RS00730	COG1419	protein localization to endoplasmic reticulum
Ga0123461_RS00745	COG1191	sigma factor activity
Ga0123461_RS00770	COG4786	Flagellar basal body rod
Ga0123461_RS00775	COG4786	Flagellar basal body rod
Ga0123461_RS00785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Ga0123461_RS00795	COG1705	Flagellar rod assembly protein muramidase FlgJ
Ga0123461_RS00795	COG3951	Flagellar rod assembly protein muramidase FlgJ
Ga0123461_RS00825	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Ga0123461_RS00830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Ga0123461_RS00835	COG0741	lytic transglycosylase activity
Ga0123461_RS00845	COG1516	flagellar protein fliS
Ga0123461_RS00860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Ga0123461_RS00865	COG1516	flagellar protein fliS
Ga0123461_RS00880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Ga0123461_RS00910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ga0123461_RS00925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ga0123461_RS00930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ga0123461_RS00940	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Ga0123461_RS00955	COG0390	transport system, permease component
Ga0123461_RS00960	COG1196	nuclear chromosome segregation
Ga0123461_RS00970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ga0123461_RS00975	COG1702	phosphate starvation-inducible protein PhoH
Ga0123461_RS00980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Ga0123461_RS00990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Ga0123461_RS00995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ga0123461_RS01010	COG0352	thiamine-phosphate diphosphorylase activity
Ga0123461_RS01025	COG0826	peptidase U32
Ga0123461_RS01035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Ga0123461_RS01045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ga0123461_RS01055	COG0752	glycyl-tRNA synthetase alpha subunit
Ga0123461_RS01060	COG0751	glycine-tRNA ligase activity
Ga0123461_RS01090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Ga0123461_RS01115	COG2205	protein histidine kinase activity
Ga0123461_RS01115	COG0784	Response regulator, receiver
Ga0123461_RS01125	COG2217	Heavy metal translocating P-type atpase
Ga0123461_RS01130	COG2814	Major facilitator Superfamily
Ga0123461_RS01145	COG0038	chloride channel
Ga0123461_RS01155	COG1393	Belongs to the ArsC family
Ga0123461_RS01160	COG0514	ATP-dependent DNA helicase (RecQ)
Ga0123461_RS01170	COG0113	porphobilinogen synthase activity
Ga0123461_RS01200	COG2171	N-acyltransferase activity
Ga0123461_RS01205	COG0019	diaminopimelate decarboxylase activity
Ga0123461_RS01210	COG0436	Aminotransferase
Ga0123461_RS01220	COG0165	Argininosuccinate lyase
Ga0123461_RS01225	COG2900	Belongs to the SlyX family
Ga0123461_RS01250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Ga0123461_RS01260	COG0583	DNA-binding transcription factor activity
Ga0123461_RS01270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Ga0123461_RS01285	COG3023	N-Acetylmuramoyl-L-alanine amidase
Ga0123461_RS01300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Ga0123461_RS01310	COG0741	lytic transglycosylase activity
Ga0123461_RS01335	COG4133	protoheme IX ABC transporter activity
Ga0123461_RS01340	COG4139	cobalamin transport
Ga0123461_RS01345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Ga0123461_RS01355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Ga0123461_RS01365	COG1492	cobalamin metabolic process
Ga0123461_RS01380	COG4206	TonB-dependent receptor
Ga0123461_RS01390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Ga0123461_RS01415	COG1136	(ABC) transporter
Ga0123461_RS01435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Ga0123461_RS01440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Ga0123461_RS01445	COG1127	ABC transporter
Ga0123461_RS01465	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ga0123461_RS01470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ga0123461_RS01480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ga0123461_RS01485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ga0123461_RS01500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Ga0123461_RS01505	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Ga0123461_RS01515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Ga0123461_RS01520	COG0543	2 iron, 2 sulfur cluster binding
Ga0123461_RS01530	COG2199	diguanylate cyclase activity
Ga0123461_RS01530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS01535	COG4191	Histidine kinase
Ga0123461_RS01540	COG2197	response regulator
Ga0123461_RS01565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS01580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ga0123461_RS01590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ga0123461_RS01595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ga0123461_RS01615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Ga0123461_RS01625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ga0123461_RS01630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ga0123461_RS01635	COG0051	transcription antitermination factor activity, RNA binding
Ga0123461_RS01640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Ga0123461_RS01645	COG0088	Forms part of the polypeptide exit tunnel
Ga0123461_RS01650	COG0089	rRNA binding
Ga0123461_RS01655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Ga0123461_RS01660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Ga0123461_RS01665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Ga0123461_RS01670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Ga0123461_RS01675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Ga0123461_RS01680	COG0255	Belongs to the universal ribosomal protein uL29 family
Ga0123461_RS01685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Ga0123461_RS01690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Ga0123461_RS01695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Ga0123461_RS01700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ga0123461_RS01710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ga0123461_RS01720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Ga0123461_RS01725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Ga0123461_RS01730	COG1841	ribosomal large subunit assembly
Ga0123461_RS01735	COG0200	Binds to the 23S rRNA
Ga0123461_RS01740	COG0201	protein transport
Ga0123461_RS01745	COG0563	adenylate kinase activity
Ga0123461_RS01750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Ga0123461_RS01755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Ga0123461_RS01760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Ga0123461_RS01765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Ga0123461_RS01770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Ga0123461_RS01775	COG0202	RNA polymerase activity
Ga0123461_RS01780	COG0203	ribosomal protein L17
Ga0123461_RS01785	COG3706	GGDEF domain
Ga0123461_RS01790	COG2917	probably involved in intracellular septation
Ga0123461_RS01800	COG0668	transmembrane transport
Ga0123461_RS01815	COG2814	Major facilitator Superfamily
Ga0123461_RS01820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Ga0123461_RS01825	COG0564	pseudouridine synthase activity
Ga0123461_RS01835	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Ga0123461_RS01845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Ga0123461_RS01925	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Ga0123461_RS01935	COG3845	ABC transporter
Ga0123461_RS01945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ga0123461_RS01965	COG0840	transmembrane signaling receptor activity
Ga0123461_RS01985	COG0643	Histidine kinase
Ga0123461_RS01985	COG0784	Response regulator, receiver
Ga0123461_RS01985	COG2198	Histidine kinase
Ga0123461_RS01995	COG3706	GGDEF domain
Ga0123461_RS01995	COG5001	Diguanylate cyclase
Ga0123461_RS01995	COG4251	negative regulation of phosphorylation
Ga0123461_RS01995	COG2203	Gaf domain
Ga0123461_RS02005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS02015	COG3012	SEC-C Motif Domain Protein
Ga0123461_RS02020	COG2983	Belongs to the UPF0260 family
Ga0123461_RS02025	COG2001	Belongs to the MraZ family
Ga0123461_RS02030	COG0275	rRNA processing
Ga0123461_RS02045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ga0123461_RS02050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Ga0123461_RS02055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ga0123461_RS02060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Ga0123461_RS02065	COG0772	Belongs to the SEDS family
Ga0123461_RS02070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ga0123461_RS02075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ga0123461_RS02080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Ga0123461_RS02100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Ga0123461_RS02105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Ga0123461_RS02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ga0123461_RS02135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Ga0123461_RS02140	COG1573	uracil-dna glycosylase
Ga0123461_RS02155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Ga0123461_RS02165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ga0123461_RS02180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ga0123461_RS02185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ga0123461_RS02190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ga0123461_RS02195	COG0649	NAD binding
Ga0123461_RS02205	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Ga0123461_RS02210	COG1034	ATP synthesis coupled electron transport
Ga0123461_RS02215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Ga0123461_RS02230	COG0713	ATP synthesis coupled electron transport
Ga0123461_RS02245	COG1007	ATP synthesis coupled electron transport
Ga0123461_RS02255	COG0356	it plays a direct role in the translocation of protons across the membrane
Ga0123461_RS02260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ga0123461_RS02270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ga0123461_RS02275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Ga0123461_RS02280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Ga0123461_RS02285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Ga0123461_RS02295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ga0123461_RS02300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ga0123461_RS02305	COG3132	Protein of unknown function, DUF480
Ga0123461_RS02310	COG0784	Response regulator, receiver
Ga0123461_RS02310	COG4191	Histidine kinase
Ga0123461_RS02315	COG0564	pseudouridine synthase activity
Ga0123461_RS02320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Ga0123461_RS02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Ga0123461_RS02330	COG1459	type II secretion system
Ga0123461_RS02335	COG5002	protein histidine kinase activity
Ga0123461_RS02350	COG0237	dephospho-CoA kinase activity
Ga0123461_RS02355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Ga0123461_RS02405	COG0714	Associated with various cellular activities
Ga0123461_RS02420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Ga0123461_RS02425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Ga0123461_RS02430	COG2853	Lipoprotein
Ga0123461_RS02435	COG0667	Aldo Keto reductase
Ga0123461_RS02440	COG0784	Response regulator, receiver
Ga0123461_RS02440	COG4191	Histidine kinase
Ga0123461_RS02450	COG0590	tRNA wobble adenosine to inosine editing
Ga0123461_RS02470	COG3592	Divergent 4Fe-4S mono-cluster
Ga0123461_RS02480	COG0435	Glutathione S-transferase
Ga0123461_RS02485	COG1902	pentaerythritol trinitrate reductase activity
Ga0123461_RS02490	COG2353	YceI-like domain
Ga0123461_RS02495	COG3038	cytochrome b561
Ga0123461_RS02505	COG0840	transmembrane signaling receptor activity
Ga0123461_RS02515	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
Ga0123461_RS02520	COG0356	it plays a direct role in the translocation of protons across the membrane
Ga0123461_RS02530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ga0123461_RS02545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ga0123461_RS02550	COG2154	pterin-4-alpha-carbinolamine dehydratase
Ga0123461_RS02560	COG4969	Belongs to the N-Me-Phe pilin family
Ga0123461_RS02605	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Ga0123461_RS02630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ga0123461_RS02635	COG1530	ribonuclease E activity
Ga0123461_RS02640	COG0424	maF-like protein
Ga0123461_RS02645	COG0142	geranyltranstransferase activity
Ga0123461_RS02665	COG1187	pseudouridine synthase activity
Ga0123461_RS02670	COG2813	Specifically methylates the guanine in position
Ga0123461_RS02680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ga0123461_RS02685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Ga0123461_RS02690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ga0123461_RS02700	COG0354	folic acid binding
Ga0123461_RS02710	COG2239	Acts as a magnesium transporter
Ga0123461_RS02715	COG0802	atpase or kinase
Ga0123461_RS02730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ga0123461_RS02735	COG2921	Belongs to the UPF0250 family
Ga0123461_RS02750	COG4657	Part of a membrane complex involved in electron transport
Ga0123461_RS02755	COG2878	Part of a membrane complex involved in electron transport
Ga0123461_RS02775	COG4660	Part of a membrane complex involved in electron transport
Ga0123461_RS02790	COG0242	peptide deformylase activity
Ga0123461_RS02795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Ga0123461_RS02800	COG1073	alpha beta
Ga0123461_RS02815	COG3706	GGDEF domain
Ga0123461_RS02820	COG0217	transcriptional regulatory protein
Ga0123461_RS02825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS02835	COG3259	Nickel-dependent hydrogenase
Ga0123461_RS02840	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Ga0123461_RS02845	COG3383	formate dehydrogenase (NAD+) activity
Ga0123461_RS02850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Ga0123461_RS02865	COG0309	Hydrogenase expression formation protein (HypE)
Ga0123461_RS02875	COG0298	carbon dioxide binding
Ga0123461_RS02885	COG0375	protein maturation
Ga0123461_RS02895	COG1643	Atp-dependent helicase
Ga0123461_RS02915	COG0308	aminopeptidase N
Ga0123461_RS02925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ga0123461_RS02940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ga0123461_RS02945	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ga0123461_RS02950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Ga0123461_RS02960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Ga0123461_RS02965	COG0072	phenylalanine-tRNA ligase activity
Ga0123461_RS02970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ga0123461_RS02985	COG0675	Transposase, IS605 OrfB family
Ga0123461_RS02995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Ga0123461_RS03000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Ga0123461_RS03030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ga0123461_RS03040	COG0450	alkyl hydroperoxide reductase
Ga0123461_RS03045	COG0653	protein targeting
Ga0123461_RS03080	COG4536	flavin adenine dinucleotide binding
Ga0123461_RS03090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Ga0123461_RS03095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Ga0123461_RS03105	COG2884	Cell division ATP-binding protein ftsE
Ga0123461_RS03110	COG2177	Part of the ABC transporter FtsEX involved in
Ga0123461_RS03120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Ga0123461_RS03135	COG5000	phosphorelay sensor kinase activity
Ga0123461_RS03140	COG2204	response regulator
Ga0123461_RS03145	COG0569	domain protein
Ga0123461_RS03150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ga0123461_RS03155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ga0123461_RS03160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Ga0123461_RS03185	COG0525	valine-tRNA ligase activity
Ga0123461_RS03200	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS03210	COG0488	(ABC) transporter
Ga0123461_RS03220	COG0301	tRNA thio-modification
Ga0123461_RS03245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Ga0123461_RS03275	COG0513	Belongs to the DEAD box helicase family
Ga0123461_RS03280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ga0123461_RS03285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ga0123461_RS03295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ga0123461_RS03300	COG1663	tetraacyldisaccharide 4'-kinase activity
Ga0123461_RS03310	COG0025	NhaP-type Na H and K H
Ga0123461_RS03325	COG1846	Transcriptional regulator
Ga0123461_RS03330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ga0123461_RS03340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ga0123461_RS03350	COG2204	response regulator
Ga0123461_RS03365	COG0542	response to heat
Ga0123461_RS03380	COG0318	PFAM AMP-dependent synthetase and ligase
Ga0123461_RS03390	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS03395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ga0123461_RS03400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ga0123461_RS03405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ga0123461_RS03430	COG0582	viral genome integration into host DNA
Ga0123461_RS03480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ga0123461_RS03520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ga0123461_RS03545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ga0123461_RS03585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ga0123461_RS03595	COG0436	Aminotransferase
Ga0123461_RS03605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ga0123461_RS03610	COG0154	amidase activity
Ga0123461_RS03615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ga0123461_RS03640	COG2329	Antibiotic biosynthesis monooxygenase
Ga0123461_RS03650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ga0123461_RS03655	COG1286	toxin biosynthetic process
Ga0123461_RS03660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Ga0123461_RS03665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Ga0123461_RS03675	COG0157	Belongs to the NadC ModD family
Ga0123461_RS03730	COG2878	Part of a membrane complex involved in electron transport
Ga0123461_RS03740	COG3842	ATPase activity
Ga0123461_RS03750	COG3547	Transposase (IS116 IS110 IS902 family)
Ga0123461_RS03770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Ga0123461_RS03780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ga0123461_RS03785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Ga0123461_RS03785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ga0123461_RS03790	COG0347	Belongs to the P(II) protein family
Ga0123461_RS03795	COG0174	glutamine synthetase
Ga0123461_RS03830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Ga0123461_RS03870	COG0517	IMP dehydrogenase activity
Ga0123461_RS03870	COG0617	tRNA 3'-terminal CCA addition
Ga0123461_RS03870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Ga0123461_RS03875	COG0268	Binds directly to 16S ribosomal RNA
Ga0123461_RS03895	COG0277	FAD linked oxidase domain protein
Ga0123461_RS03895	COG0277	FAD linked oxidase domain protein
Ga0123461_RS03925	COG0432	Pfam Uncharacterised protein family UPF0047
Ga0123461_RS03945	COG1393	Belongs to the ArsC family
Ga0123461_RS03960	COG1525	nuclease
Ga0123461_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
Ga0123461_RS03980	COG0488	(ABC) transporter
Ga0123461_RS03995	COG5016	pyruvate
Ga0123461_RS03995	COG0511	ligase activity, forming carbon-carbon bonds
Ga0123461_RS04000	COG0439	Biotin carboxylase
Ga0123461_RS04005	COG4999	Histidine kinase
Ga0123461_RS04005	COG3437	response regulator, receiver
Ga0123461_RS04005	COG3850	Histidine kinase
Ga0123461_RS04005	COG2205	protein histidine kinase activity
Ga0123461_RS04010	COG2202	Pas domain
Ga0123461_RS04010	COG2205	protein histidine kinase activity
Ga0123461_RS04020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ga0123461_RS04025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ga0123461_RS04030	COG0805	protein transport
Ga0123461_RS04045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ga0123461_RS04050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ga0123461_RS04055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Ga0123461_RS04065	COG1420	regulation of RNA biosynthetic process
Ga0123461_RS04070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ga0123461_RS04080	COG0484	heat shock protein binding
Ga0123461_RS04085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Ga0123461_RS04095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Ga0123461_RS04105	COG0811	peptide transport
Ga0123461_RS04110	COG0848	biopolymer transport protein
Ga0123461_RS04135	COG0348	domain, Protein
Ga0123461_RS04145	COG0457	Tetratricopeptide repeat
Ga0123461_RS04155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ga0123461_RS04170	COG0052	Belongs to the universal ribosomal protein uS2 family
Ga0123461_RS04175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ga0123461_RS04180	COG0528	UMP kinase activity
Ga0123461_RS04185	COG0233	cytoplasmic translational termination
Ga0123461_RS04190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ga0123461_RS04195	COG0575	Belongs to the CDS family
Ga0123461_RS04200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Ga0123461_RS04205	COG0750	zinc metalloprotease
Ga0123461_RS04210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ga0123461_RS04220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ga0123461_RS04225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ga0123461_RS04230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ga0123461_RS04235	COG3494	Protein of unknown function (DUF1009)
Ga0123461_RS04250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Ga0123461_RS04265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Ga0123461_RS04270	COG0416	fatty acid biosynthetic process
Ga0123461_RS04275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ga0123461_RS04280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ga0123461_RS04290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ga0123461_RS04295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ga0123461_RS04300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ga0123461_RS04310	COG0305	Participates in initiation and elongation during chromosome replication
Ga0123461_RS04315	COG0359	binds to the 23S rRNA
Ga0123461_RS04325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Ga0123461_RS04335	COG0360	Binds together with S18 to 16S ribosomal RNA
Ga0123461_RS04345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ga0123461_RS04345	COG0574	Belongs to the PEP-utilizing enzyme family
Ga0123461_RS04365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ga0123461_RS04385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Ga0123461_RS04390	COG0129	dihydroxy-acid dehydratase activity
Ga0123461_RS04405	COG1362	aminopeptidase activity
Ga0123461_RS04435	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ga0123461_RS04445	COG0564	pseudouridine synthase activity
Ga0123461_RS04490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Ga0123461_RS04520	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Ga0123461_RS04530	COG0084	hydrolase, TatD family'
Ga0123461_RS04535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ga0123461_RS04540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ga0123461_RS04565	COG0281	malic enzyme
Ga0123461_RS04580	COG0307	riboflavin synthase, alpha
Ga0123461_RS04585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ga0123461_RS04585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ga0123461_RS04590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Ga0123461_RS04595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ga0123461_RS04600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ga0123461_RS04605	COG0546	phosphoglycolate phosphatase activity
Ga0123461_RS04610	COG0352	thiamine-phosphate diphosphorylase activity
Ga0123461_RS04615	COG0351	phosphomethylpyrimidine kinase
Ga0123461_RS04615	COG0352	thiamine-phosphate diphosphorylase activity
Ga0123461_RS04620	COG0625	glutathione transferase activity
Ga0123461_RS04640	COG0300	oxidoreductase activity
Ga0123461_RS04670	COG0488	(ABC) transporter
Ga0123461_RS04675	COG0432	Pfam Uncharacterised protein family UPF0047
Ga0123461_RS04700	COG0481	GTPase activity
Ga0123461_RS04705	COG0681	Belongs to the peptidase S26 family
Ga0123461_RS04715	COG0571	ribonuclease III activity
Ga0123461_RS04720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ga0123461_RS04725	COG1381	Involved in DNA repair and RecF pathway recombination
Ga0123461_RS04730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Ga0123461_RS04735	COG0736	holo-[acyl-carrier-protein] synthase activity
Ga0123461_RS04745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ga0123461_RS04745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ga0123461_RS04760	COG1053	succinate dehydrogenase
Ga0123461_RS04765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ga0123461_RS04780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Ga0123461_RS04785	COG0723	plastoquinol--plastocyanin reductase activity
Ga0123461_RS04805	COG0436	Aminotransferase
Ga0123461_RS04815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Ga0123461_RS04825	COG0840	transmembrane signaling receptor activity
Ga0123461_RS04830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Ga0123461_RS04830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ga0123461_RS04855	COG1217	gtp-binding protein TYPA
Ga0123461_RS04860	COG0024	Methionine aminopeptidase
Ga0123461_RS04895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Ga0123461_RS04900	COG0033	Phosphoglucomutase
Ga0123461_RS04905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Ga0123461_RS04910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ga0123461_RS04935	COG3437	response regulator, receiver
Ga0123461_RS04955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ga0123461_RS04960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ga0123461_RS04970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ga0123461_RS05015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ga0123461_RS05025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Ga0123461_RS05030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Ga0123461_RS05035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Ga0123461_RS05040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Ga0123461_RS05045	COG0473	3-isopropylmalate dehydrogenase activity
Ga0123461_RS05050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ga0123461_RS05065	COG0101	tRNA pseudouridine synthase activity
Ga0123461_RS05075	COG0483	inositol monophosphate 1-phosphatase activity
Ga0123461_RS05085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ga0123461_RS05095	COG1674	ftsk spoiiie
Ga0123461_RS05110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ga0123461_RS05115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ga0123461_RS05120	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS05125	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS05125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ga0123461_RS05130	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ga0123461_RS05140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ga0123461_RS05155	COG1131	(ABC) transporter
Ga0123461_RS05185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ga0123461_RS05185	COG0425	Belongs to the sulfur carrier protein TusA family
Ga0123461_RS05190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ga0123461_RS05195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ga0123461_RS05245	COG0606	chelatase, subunit chli
Ga0123461_RS05250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS05285	COG0163	prenyltransferase activity
Ga0123461_RS05290	COG1137	ATPase activity
Ga0123461_RS05305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Ga0123461_RS05310	COG0517	IMP dehydrogenase activity
Ga0123461_RS05310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Ga0123461_RS05320	COG1666	GTP binding
Ga0123461_RS05325	COG1104	cysteine desulfurase activity
Ga0123461_RS05355	COG0784	Response regulator, receiver
Ga0123461_RS05355	COG4191	Histidine kinase
Ga0123461_RS05375	COG0784	Response regulator, receiver
Ga0123461_RS05375	COG4191	Histidine kinase
Ga0123461_RS05415	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Ga0123461_RS05425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ga0123461_RS05435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Ga0123461_RS05450	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS05460	COG4565	transcriptional regulatory protein
Ga0123461_RS05465	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS05470	COG5001	Diguanylate cyclase
Ga0123461_RS05470	COG4251	negative regulation of phosphorylation
Ga0123461_RS05470	COG3706	GGDEF domain
Ga0123461_RS05470	COG2203	Gaf domain
Ga0123461_RS05480	COG3852	Histidine kinase
Ga0123461_RS05485	COG5002	protein histidine kinase activity
Ga0123461_RS05490	COG1335	isochorismatase
Ga0123461_RS05520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ga0123461_RS05525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Ga0123461_RS05540	COG2176	DNA-directed DNA polymerase activity
Ga0123461_RS05560	COG0676	glucose-6-phosphate 1-epimerase activity
Ga0123461_RS05575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Ga0123461_RS05585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ga0123461_RS05585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ga0123461_RS05595	COG3001	Fructosamine kinase
Ga0123461_RS05605	COG0312	modulator of DNA gyrase
Ga0123461_RS05610	COG0312	modulator of DNA gyrase
Ga0123461_RS05620	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Ga0123461_RS05625	COG0330	HflC and HflK could
Ga0123461_RS05630	COG0330	HflC and HflK could
Ga0123461_RS05645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ga0123461_RS05650	COG0194	GDP metabolic process
Ga0123461_RS05655	COG1758	RNA polymerase activity
Ga0123461_RS05670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Ga0123461_RS05675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ga0123461_RS05685	COG4191	Histidine kinase
Ga0123461_RS05685	COG0784	Response regulator, receiver
Ga0123461_RS05700	COG2226	methyltransferase
Ga0123461_RS05705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ga0123461_RS05705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ga0123461_RS05710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Ga0123461_RS05720	COG1546	Belongs to the CinA family
Ga0123461_RS05720	COG1058	Belongs to the CinA family
Ga0123461_RS05725	COG0647	UMP catabolic process
Ga0123461_RS05740	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Ga0123461_RS05745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Ga0123461_RS05745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Ga0123461_RS05750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Ga0123461_RS05765	COG0463	Glycosyl transferase, family 2
Ga0123461_RS05775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ga0123461_RS05795	COG2192	nodulation
Ga0123461_RS05815	COG0859	PFAM glycosyl transferase family 9
Ga0123461_RS05835	COG2835	tetraacyldisaccharide 4'-kinase activity
Ga0123461_RS05840	COG0670	Belongs to the BI1 family
Ga0123461_RS05845	COG3030	protein affecting phage T7 exclusion by the F plasmid
Ga0123461_RS05865	COG1162	GTPase activity
Ga0123461_RS05875	COG2116	formate transmembrane transporter activity
Ga0123461_RS05880	COG0513	Belongs to the DEAD box helicase family
Ga0123461_RS05890	COG1473	amidohydrolase
Ga0123461_RS05895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Ga0123461_RS05900	COG2974	May be involved in recombination
Ga0123461_RS05905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Ga0123461_RS05915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Ga0123461_RS05930	COG0604	alcohol dehydrogenase
Ga0123461_RS05945	COG2095	MarC family integral membrane protein
Ga0123461_RS05950	COG0724	RNA recognition motif
Ga0123461_RS05960	COG4115	mRNA cleavage
Ga0123461_RS05965	COG0252	asparaginase activity
Ga0123461_RS05970	COG4628	conserved protein (DUF2132)
Ga0123461_RS05975	COG1643	Atp-dependent helicase
Ga0123461_RS05980	COG0688	phosphatidylethanolamine metabolic process
Ga0123461_RS05990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ga0123461_RS06010	COG3040	lipid binding
Ga0123461_RS06020	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Ga0123461_RS06025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ga0123461_RS06035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Ga0123461_RS06055	COG0488	(ABC) transporter
Ga0123461_RS06065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Ga0123461_RS06075	COG0529	Catalyzes the synthesis of activated sulfate
Ga0123461_RS06105	COG2755	lipolytic protein G-D-S-L family
Ga0123461_RS06105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Ga0123461_RS06135	COG1215	transferase activity, transferring glycosyl groups
Ga0123461_RS06150	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ga0123461_RS06165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ga0123461_RS06215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ga0123461_RS06250	COG0316	Belongs to the HesB IscA family
Ga0123461_RS06255	COG1131	(ABC) transporter
Ga0123461_RS06260	COG0842	Transport permease protein
Ga0123461_RS06265	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Ga0123461_RS06270	COG0590	tRNA wobble adenosine to inosine editing
Ga0123461_RS06275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ga0123461_RS06280	COG0601	transmembrane transport
Ga0123461_RS06300	COG0582	viral genome integration into host DNA
Ga0123461_RS06320	COG3956	TIGRFAM MazG family protein
Ga0123461_RS06325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ga0123461_RS06370	COG1733	regulation of RNA biosynthetic process
Ga0123461_RS06390	COG0572	uridine kinase
Ga0123461_RS06395	COG1230	cation diffusion facilitator family transporter
Ga0123461_RS06400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ga0123461_RS06425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ga0123461_RS06460	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS06465	COG4251	negative regulation of phosphorylation
Ga0123461_RS06470	COG4251	negative regulation of phosphorylation
Ga0123461_RS06475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ga0123461_RS06490	COG4566	intracellular signal transduction
Ga0123461_RS06535	COG1562	ergosterol biosynthetic process
Ga0123461_RS06540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Ga0123461_RS06545	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Ga0123461_RS06550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Ga0123461_RS06555	COG0632	four-way junction helicase activity
Ga0123461_RS06560	COG2255	four-way junction helicase activity
Ga0123461_RS06565	COG0824	Thioesterase
Ga0123461_RS06600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ga0123461_RS06620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Ga0123461_RS06625	COG4221	oxidoreductase activity
Ga0123461_RS06630	COG0067	glutamate synthase
Ga0123461_RS06630	COG0069	glutamate synthase activity
Ga0123461_RS06630	COG0070	glutamate synthase
Ga0123461_RS06645	COG0475	glutathione-regulated potassium exporter activity
Ga0123461_RS06650	COG3264	Mechanosensitive ion channel
Ga0123461_RS06650	COG1511	domain protein
Ga0123461_RS06655	COG4067	protein conserved in archaea
Ga0123461_RS06655	COG0189	ligase activity
Ga0123461_RS06660	COG0189	ligase activity
Ga0123461_RS06690	COG4106	trans-aconitate 2-methyltransferase activity
Ga0123461_RS06695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ga0123461_RS06700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Ga0123461_RS06715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Ga0123461_RS06720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ga0123461_RS06730	COG0195	Participates in both transcription termination and antitermination
Ga0123461_RS06735	COG0779	Required for maturation of 30S ribosomal subunits
Ga0123461_RS06755	COG0328	RNA-DNA hybrid ribonuclease activity
Ga0123461_RS06760	COG1663	tetraacyldisaccharide 4'-kinase activity
Ga0123461_RS06785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ga0123461_RS06800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Ga0123461_RS06805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ga0123461_RS06810	COG0739	heme binding
Ga0123461_RS06810	COG1388	LysM domain
Ga0123461_RS06815	COG1238	metal cluster binding
Ga0123461_RS06820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ga0123461_RS06835	COG0776	regulation of translation
Ga0123461_RS06840	COG1136	(ABC) transporter
Ga0123461_RS06850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Ga0123461_RS06855	COG0105	UTP biosynthetic process
Ga0123461_RS06860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Ga0123461_RS06865	COG0602	queuosine metabolic process
Ga0123461_RS06880	COG0823	Involved in the tonB-independent uptake of proteins
Ga0123461_RS06885	COG0004	ammonium transporteR
Ga0123461_RS06895	COG0004	ammonium transporteR
Ga0123461_RS06900	COG0347	Belongs to the P(II) protein family
Ga0123461_RS06915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ga0123461_RS06920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Ga0123461_RS06925	COG3474	cytochrome
Ga0123461_RS06945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Ga0123461_RS06950	COG2022	thiamine diphosphate biosynthetic process
Ga0123461_RS06965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Ga0123461_RS06970	COG0511	ligase activity, forming carbon-carbon bonds
Ga0123461_RS06980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ga0123461_RS06985	COG1183	phosphatidylcholine synthase activity
Ga0123461_RS06990	COG0688	phosphatidylethanolamine metabolic process
Ga0123461_RS07005	COG0577	efflux transmembrane transporter activity
Ga0123461_RS07005	COG1136	(ABC) transporter
Ga0123461_RS07010	COG0577	efflux transmembrane transporter activity
Ga0123461_RS07010	COG1136	(ABC) transporter
Ga0123461_RS07030	COG4968	Prepilin-type N-terminal cleavage methylation domain
Ga0123461_RS07035	COG1131	(ABC) transporter
Ga0123461_RS07055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ga0123461_RS07085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ga0123461_RS07095	COG1074	ATP-dependent DNA helicase activity
Ga0123461_RS07135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Ga0123461_RS07140	COG0045	succinate-CoA ligase (ADP-forming) activity
Ga0123461_RS07145	COG0039	L-malate dehydrogenase activity
Ga0123461_RS07155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ga0123461_RS07165	COG1388	LysM domain
Ga0123461_RS07165	COG0791	NLP P60 protein
Ga0123461_RS07175	COG0686	Belongs to the AlaDH PNT family
Ga0123461_RS07180	COG0450	alkyl hydroperoxide reductase
Ga0123461_RS07185	COG2914	Belongs to the UPF0125 (RnfH) family
Ga0123461_RS07190	COG2867	negative regulation of translational initiation
Ga0123461_RS07195	COG1160	GTP binding
Ga0123461_RS07220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ga0123461_RS07250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Ga0123461_RS07255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Ga0123461_RS07270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ga0123461_RS07275	COG2951	lytic endotransglycosylase activity
Ga0123461_RS07285	COG1611	Belongs to the LOG family
Ga0123461_RS07295	COG1686	Belongs to the peptidase S11 family
Ga0123461_RS07305	COG0546	phosphoglycolate phosphatase activity
Ga0123461_RS07310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Ga0123461_RS07325	COG4106	trans-aconitate 2-methyltransferase activity
Ga0123461_RS07330	COG2423	ornithine cyclodeaminase activity
Ga0123461_RS07345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ga0123461_RS07350	COG0251	oxidation-reduction process
Ga0123461_RS07360	COG4628	conserved protein (DUF2132)
Ga0123461_RS07390	COG0463	Glycosyl transferase, family 2
Ga0123461_RS07415	COG4964	Belongs to the GSP D family
Ga0123461_RS07475	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Ga0123461_RS07490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ga0123461_RS07490	COG0574	Belongs to the PEP-utilizing enzyme family
Ga0123461_RS07500	COG0531	amino acid
Ga0123461_RS07525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Ga0123461_RS07535	COG5016	pyruvate
Ga0123461_RS07535	COG0511	ligase activity, forming carbon-carbon bonds
Ga0123461_RS07540	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Ga0123461_RS07545	COG1047	Peptidyl-prolyl cis-trans
Ga0123461_RS07560	COG1322	Protein conserved in bacteria
Ga0123461_RS07565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Ga0123461_RS07585	COG1115	amino acid carrier protein
Ga0123461_RS07590	COG1199	ATP-dependent helicase activity
Ga0123461_RS07595	COG4608	Belongs to the ABC transporter superfamily
Ga0123461_RS07605	COG0114	fumarate hydratase activity
Ga0123461_RS07610	COG2770	Histidine kinase
Ga0123461_RS07610	COG2208	phosphoserine phosphatase activity
Ga0123461_RS07615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ga0123461_RS07680	COG0180	Tryptophanyl-tRNA synthetase
Ga0123461_RS07690	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Ga0123461_RS07695	COG1187	pseudouridine synthase activity
Ga0123461_RS07705	COG0322	excinuclease ABC activity
Ga0123461_RS07730	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS07730	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS07730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ga0123461_RS07730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ga0123461_RS07735	COG0210	DNA helicase
Ga0123461_RS07760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Ga0123461_RS07775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ga0123461_RS07785	COG3118	belongs to the thioredoxin family
Ga0123461_RS07800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Ga0123461_RS07815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Ga0123461_RS07835	COG0343	queuine tRNA-ribosyltransferase activity
Ga0123461_RS07840	COG1862	Preprotein translocase
Ga0123461_RS07845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ga0123461_RS07850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ga0123461_RS07885	COG0823	Involved in the tonB-independent uptake of proteins
Ga0123461_RS07895	COG0166	Belongs to the GPI family
Ga0123461_RS07900	COG0297	glycogen (starch) synthase activity
Ga0123461_RS07910	COG1739	Uncharacterized protein family UPF0029
Ga0123461_RS07915	COG0058	SHG alpha-glucan phosphorylase activity
Ga0123461_RS07920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ga0123461_RS07920	COG0515	serine threonine protein kinase
Ga0123461_RS07940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS07945	COG0205	6-phosphofructokinase activity
Ga0123461_RS07950	COG0483	inositol monophosphate 1-phosphatase activity
Ga0123461_RS07955	COG1494	fructose-1,6-bisphosphatase
Ga0123461_RS07960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Ga0123461_RS07965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Ga0123461_RS07970	COG0126	phosphoglycerate kinase activity
Ga0123461_RS07975	COG0469	pyruvate kinase activity
Ga0123461_RS07995	COG0501	Belongs to the peptidase M48B family
Ga0123461_RS08000	COG1704	LemA family
Ga0123461_RS08005	COG2270	Major facilitator Superfamily
Ga0123461_RS08020	COG0471	metal ion transport
Ga0123461_RS08035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Ga0123461_RS08045	COG0140	phosphoribosyl-ATP diphosphatase activity
Ga0123461_RS08050	COG4651	solute:proton antiporter activity
Ga0123461_RS08050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ga0123461_RS08055	COG2205	protein histidine kinase activity
Ga0123461_RS08055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ga0123461_RS08065	COG2824	Alkylphosphonate utilization operon protein PhnA
Ga0123461_RS08115	COG1530	ribonuclease E activity
Ga0123461_RS08120	COG0564	pseudouridine synthase activity
Ga0123461_RS08125	COG1496	oxidoreductase activity
Ga0123461_RS08130	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ga0123461_RS08140	COG1960	acyl-CoA dehydrogenase activity
Ga0123461_RS08160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Ga0123461_RS08165	COG3028	Belongs to the UPF0307 family
Ga0123461_RS08180	COG1999	signal sequence binding
Ga0123461_RS08185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ga0123461_RS08185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ga0123461_RS08195	COG2873	o-acetylhomoserine
Ga0123461_RS08200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Ga0123461_RS08205	COG0302	gtp cyclohydrolase
Ga0123461_RS08220	COG0655	NAD(P)H dehydrogenase (quinone) activity
Ga0123461_RS08225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Ga0123461_RS08240	COG2770	Histidine kinase
Ga0123461_RS08240	COG3437	response regulator, receiver
Ga0123461_RS08245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ga0123461_RS08245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ga0123461_RS08270	COG2814	Major facilitator Superfamily
Ga0123461_RS08275	COG1612	heme a metabolic process
Ga0123461_RS08280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ga0123461_RS08320	COG0109	protoheme IX farnesyltransferase activity
Ga0123461_RS08355	COG0497	DNA recombination
Ga0123461_RS08360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Ga0123461_RS08405	COG0463	Glycosyl transferase, family 2
Ga0123461_RS08410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Ga0123461_RS08425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ga0123461_RS08430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ga0123461_RS08440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ga0123461_RS08450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Ga0123461_RS08455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ga0123461_RS08455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Ga0123461_RS08460	COG0275	rRNA processing
Ga0123461_RS08480	COG3100	YcgL domain-containing protein
Ga0123461_RS08480	COG0561	phosphatase activity
Ga0123461_RS08485	COG0438	transferase activity, transferring glycosyl groups
Ga0123461_RS08500	COG1022	Amp-dependent synthetase and ligase
Ga0123461_RS08505	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ga0123461_RS08505	COG1024	Enoyl-CoA hydratase
Ga0123461_RS08520	COG1994	Peptidase M50
Ga0123461_RS08530	COG0505	Belongs to the CarA family
Ga0123461_RS08535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ga0123461_RS08540	COG0556	nucleotide-excision repair
Ga0123461_RS08550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Ga0123461_RS08560	COG0393	Putative heavy-metal-binding
Ga0123461_RS08570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ga0123461_RS08575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ga0123461_RS08575	COG0519	Catalyzes the synthesis of GMP from XMP
Ga0123461_RS08580	COG3706	GGDEF domain
Ga0123461_RS08640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ga0123461_RS08690	COG0629	single-stranded DNA binding
Ga0123461_RS08710	COG0235	Class ii aldolase
Ga0123461_RS08725	COG5002	protein histidine kinase activity
Ga0123461_RS08735	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS08755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ga0123461_RS08760	COG0573	inorganic phosphate transmembrane transporter activity
Ga0123461_RS08765	COG0573	inorganic phosphate transmembrane transporter activity
Ga0123461_RS08770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Ga0123461_RS08775	COG0704	Plays a role in the regulation of phosphate uptake
Ga0123461_RS08780	COG0306	phosphate transporter
Ga0123461_RS08785	COG1392	Phosphate transport regulator
Ga0123461_RS08810	COG2326	polyphosphate kinase activity
Ga0123461_RS08820	COG2326	polyphosphate kinase activity
Ga0123461_RS08825	COG0248	Ppx GppA phosphatase
Ga0123461_RS08835	COG1570	exodeoxyribonuclease VII activity
Ga0123461_RS08855	COG0405	Gamma-glutamyltransferase
Ga0123461_RS08865	COG1428	Deoxynucleoside kinase
Ga0123461_RS08875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Ga0123461_RS08880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Ga0123461_RS08885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Ga0123461_RS08890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Ga0123461_RS08900	COG3706	GGDEF domain
Ga0123461_RS08900	COG4251	negative regulation of phosphorylation
Ga0123461_RS08900	COG5001	Diguanylate cyclase
Ga0123461_RS08900	COG2203	Gaf domain
Ga0123461_RS08930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Ga0123461_RS08950	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ga0123461_RS08955	COG0567	Dehydrogenase, E1 component
Ga0123461_RS08960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Ga0123461_RS08995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Ga0123461_RS09000	COG0248	Ppx GppA phosphatase
Ga0123461_RS09000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ga0123461_RS09010	COG1132	(ABC) transporter
Ga0123461_RS09015	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ga0123461_RS09020	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Ga0123461_RS09020	COG0662	Cupin 2, conserved barrel domain protein
Ga0123461_RS09070	COG0631	protein serine/threonine phosphatase activity
Ga0123461_RS09075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Ga0123461_RS09085	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Ga0123461_RS09095	COG0776	regulation of translation
Ga0123461_RS09100	COG0539	negative regulation of cytoplasmic translation
Ga0123461_RS09105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Ga0123461_RS09110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Ga0123461_RS09115	COG0287	Prephenate dehydrogenase
Ga0123461_RS09125	COG0077	Prephenate dehydratase
Ga0123461_RS09125	COG1605	Chorismate mutase
Ga0123461_RS09130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ga0123461_RS09140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ga0123461_RS09150	COG1596	polysaccharide export
Ga0123461_RS09150	COG1555	photosystem II stabilization
Ga0123461_RS09160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ga0123461_RS09195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ga0123461_RS09250	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ga0123461_RS09300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Ga0123461_RS09320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Ga0123461_RS09325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ga0123461_RS09335	COG1127	ABC transporter
Ga0123461_RS09370	COG0776	regulation of translation
Ga0123461_RS09385	COG0740	serine-type endopeptidase activity
Ga0123461_RS09390	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ga0123461_RS09415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Ga0123461_RS09420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ga0123461_RS09425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ga0123461_RS09430	COG0756	dUTP diphosphatase activity
Ga0123461_RS09440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Ga0123461_RS09445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ga0123461_RS09460	COG0196	riboflavin kinase activity
Ga0123461_RS09465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Ga0123461_RS09470	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
Ga0123461_RS09485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ga0123461_RS09485	COG0519	Catalyzes the synthesis of GMP from XMP
Ga0123461_RS09490	COG0516	GMP reductase activity
Ga0123461_RS09490	COG0517	IMP dehydrogenase activity
Ga0123461_RS09495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Ga0123461_RS09520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ga0123461_RS09530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ga0123461_RS09540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Ga0123461_RS09560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Ga0123461_RS09570	COG0012	GTP binding
Ga0123461_RS09575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Ga0123461_RS09580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Ga0123461_RS09595	COG0204	Acyl-transferase
Ga0123461_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
Ga0123461_RS09600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Ga0123461_RS09605	COG4191	Histidine kinase
Ga0123461_RS09605	COG0784	Response regulator, receiver
Ga0123461_RS09615	COG0492	ferredoxin-NADP+ reductase activity
Ga0123461_RS09620	COG2239	Acts as a magnesium transporter
Ga0123461_RS09625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ga0123461_RS09630	COG0560	Phosphoserine phosphatase
Ga0123461_RS09640	COG1295	ribonuclease BN
Ga0123461_RS09650	COG4191	Histidine kinase
Ga0123461_RS09650	COG0784	Response regulator, receiver
Ga0123461_RS09655	COG2833	Protein of unknown function (DUF455)
Ga0123461_RS09660	COG2915	High frequency lysogenization protein hflD homolog
Ga0123461_RS09675	COG0659	secondary active sulfate transmembrane transporter activity
Ga0123461_RS09685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Ga0123461_RS09690	COG0792	nuclease activity
Ga0123461_RS09695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Ga0123461_RS09710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Ga0123461_RS09710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Ga0123461_RS09715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ga0123461_RS09735	COG0215	cysteine-tRNA ligase activity
Ga0123461_RS09740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ga0123461_RS09750	COG0148	phosphopyruvate hydratase activity
Ga0123461_RS09755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Ga0123461_RS09760	COG0504	CTP synthase activity
Ga0123461_RS09765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ga0123461_RS09765	COG0047	phosphoribosylformylglycinamidine synthase activity
Ga0123461_RS09770	COG4191	Histidine kinase
Ga0123461_RS09785	COG2996	Protein conserved in bacteria
Ga0123461_RS09795	COG2183	response to ionizing radiation
Ga0123461_RS09820	COG1846	Transcriptional regulator
Ga0123461_RS09825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Ga0123461_RS09830	COG3123	guanosine phosphorylase activity
Ga0123461_RS09835	COG0010	Belongs to the arginase family
Ga0123461_RS09855	COG0433	COG0433 Predicted ATPase
Ga0123461_RS09860	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Ga0123461_RS09865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Ga0123461_RS09870	COG0363	glucosamine-6-phosphate deaminase activity
Ga0123461_RS09875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Ga0123461_RS09890	COG0501	Belongs to the peptidase M48B family
Ga0123461_RS09915	COG1451	nucleotide metabolic process
Ga0123461_RS09925	COG2814	Major facilitator Superfamily
Ga0123461_RS09970	COG0513	Belongs to the DEAD box helicase family
Ga0123461_RS09980	COG1166	arginine decarboxylase activity
Ga0123461_RS09985	COG0336	Belongs to the RNA methyltransferase TrmD family
Ga0123461_RS09990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Ga0123461_RS09995	COG0228	four-way junction DNA binding
Ga0123461_RS10000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ga0123461_RS10005	COG2895	sulfate adenylyltransferase (ATP) activity
Ga0123461_RS10010	COG0175	sulfate reduction
Ga0123461_RS10015	COG0175	sulfate reduction
Ga0123461_RS10020	COG0471	metal ion transport
Ga0123461_RS10030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Ga0123461_RS10045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Ga0123461_RS10055	COG0489	protein tyrosine kinase activity
Ga0123461_RS10060	COG2210	Belongs to the sulfur carrier protein TusA family
Ga0123461_RS10065	COG0425	Belongs to the sulfur carrier protein TusA family
Ga0123461_RS10070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ga0123461_RS10085	COG1671	Belongs to the UPF0178 family
Ga0123461_RS10095	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ga0123461_RS10110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Ga0123461_RS10115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Ga0123461_RS10125	COG4585	Histidine kinase
Ga0123461_RS10130	COG2197	response regulator
Ga0123461_RS10135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ga0123461_RS10140	COG0501	Belongs to the peptidase M48B family
Ga0123461_RS10145	COG1058	Belongs to the CinA family
Ga0123461_RS10145	COG1546	Belongs to the CinA family
Ga0123461_RS10160	COG1355	regulation of microtubule-based process
Ga0123461_RS10165	COG4771	TonB-dependent receptor
Ga0123461_RS10185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Ga0123461_RS10190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Ga0123461_RS10195	COG0131	Imidazoleglycerol-phosphate dehydratase
Ga0123461_RS10200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ga0123461_RS10205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Ga0123461_RS10210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Ga0123461_RS10215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ga0123461_RS10220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Ga0123461_RS10225	COG0552	protein localization to endoplasmic reticulum
Ga0123461_RS10255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ga0123461_RS10265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Ga0123461_RS10270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Ga0123461_RS10280	COG0442	prolyl-tRNA aminoacylation
Ga0123461_RS10295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Ga0123461_RS10300	COG0527	aspartate kinase activity
Ga0123461_RS10330	COG2814	Major facilitator Superfamily
Ga0123461_RS10340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ga0123461_RS10345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ga0123461_RS10370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Ga0123461_RS10385	COG3706	GGDEF domain
Ga0123461_RS10400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Ga0123461_RS10405	COG0281	malic enzyme
Ga0123461_RS10405	COG0280	phosphate acetyltransferase
Ga0123461_RS10410	COG0741	lytic transglycosylase activity
Ga0123461_RS10410	COG1196	nuclear chromosome segregation
Ga0123461_RS10410	COG0739	heme binding
Ga0123461_RS10420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Ga0123461_RS10440	COG0372	Belongs to the citrate synthase family
Ga0123461_RS10450	COG0583	DNA-binding transcription factor activity
Ga0123461_RS10475	COG0018	arginyl-trna synthetase
Ga0123461_RS10480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ga0123461_RS10485	COG0242	peptide deformylase activity
Ga0123461_RS10495	COG0316	Belongs to the HesB IscA family
Ga0123461_RS10510	COG1045	serine acetyltransferase
Ga0123461_RS10515	COG0612	Peptidase, M16
Ga0123461_RS10520	COG1185	polyribonucleotide nucleotidyltransferase activity
Ga0123461_RS10525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Ga0123461_RS10530	COG1301	dicarboxylic acid transport
Ga0123461_RS10565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ga0123461_RS10570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Ga0123461_RS10580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Ga0123461_RS10585	COG1678	Uncharacterized ACR, COG1678
Ga0123461_RS10590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ga0123461_RS10605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Ga0123461_RS10615	COG0037	tRNA processing
Ga0123461_RS10625	COG0803	Belongs to the bacterial solute-binding protein 9 family
Ga0123461_RS10635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ga0123461_RS10650	COG1966	Carbon starvation protein
Ga0123461_RS10655	COG0587	DNA-directed DNA polymerase activity
Ga0123461_RS10660	COG0825	malonyl-CoA metabolic process
Ga0123461_RS10670	COG1278	Cold shock
Ga0123461_RS10695	COG0628	permease
Ga0123461_RS10700	COG1403	HNH endonuclease
Ga0123461_RS10735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ga0123461_RS10745	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Ga0123461_RS10750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Ga0123461_RS10780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ga0123461_RS10790	COG1238	metal cluster binding
Ga0123461_RS10795	COG5002	protein histidine kinase activity
Ga0123461_RS10800	COG0784	Response regulator, receiver
Ga0123461_RS10800	COG4191	Histidine kinase
Ga0123461_RS10805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Ga0123461_RS10810	COG2205	protein histidine kinase activity
Ga0123461_RS10810	COG0784	Response regulator, receiver
Ga0123461_RS10830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Ga0123461_RS10865	COG0493	'glutamate synthase
Ga0123461_RS10870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ga0123461_RS10870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ga0123461_RS10870	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS10870	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ga0123461_RS10890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ga0123461_RS10895	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ga0123461_RS10900	COG0022	dehydrogenase e1 component
Ga0123461_RS10905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Ga0123461_RS10940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ga0123461_RS10945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Ga0123461_RS10950	COG0084	hydrolase, TatD family'
Ga0123461_RS10960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ga0123461_RS10970	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Ga0123461_RS10975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Ga0123461_RS10985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ga0123461_RS11000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ga0123461_RS11020	COG0066	3-isopropylmalate dehydratase activity
Ga0123461_RS11025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ga0123461_RS11030	COG0583	DNA-binding transcription factor activity
Ga0123461_RS11035	COG0717	Belongs to the dCTP deaminase family
Ga0123461_RS11040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Ga0123461_RS11050	COG0385	Bile acid
Ga0123461_RS11075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ga0123461_RS11100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ga0123461_RS11120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Ga0123461_RS11130	COG2199	diguanylate cyclase activity
Ga0123461_RS11130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Ga0123461_RS11135	COG0372	Belongs to the citrate synthase family
Ga0123461_RS11150	COG0557	exoribonuclease II activity
Ga0123461_RS11165	COG5001	Diguanylate cyclase
Ga0123461_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ga0123461_RS11205	COG0495	leucyl-tRNA aminoacylation
Ga0123461_RS11210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ga0123461_RS11215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ga0123461_RS11220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ga0123461_RS11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ga0123461_RS11240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Ga0123461_RS11250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ga0123461_RS11370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Ga0123461_RS11380	COG4335	DNA alkylation repair
Ga0123461_RS11410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Ga0123461_RS11415	COG2226	methyltransferase
Ga0123461_RS11425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ga0123461_RS11430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Ga0123461_RS11435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Ga0123461_RS11450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Ga0123461_RS11455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ga0123461_RS11460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ga0123461_RS11465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ga0123461_RS11470	COG2081	HI0933 family
Ga0123461_RS11475	COG2204	response regulator
Ga0123461_RS11490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Ga0123461_RS11505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Ga0123461_RS11515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ga0123461_RS11530	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Ga0123461_RS11540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Ga0123461_RS11550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Ga0123461_RS11575	COG1959	2 iron, 2 sulfur cluster binding
Ga0123461_RS11580	COG1151	hydroxylamine reductase activity
Ga0123461_RS11585	COG0633	Ferredoxin
Ga0123461_RS11585	COG0543	2 iron, 2 sulfur cluster binding
Ga0123461_RS11595	COG0668	transmembrane transport
Ga0123461_RS11600	COG1028	Short-chain dehydrogenase reductase Sdr
Ga0123461_RS11620	COG1194	a g-specific adenine glycosylase
Ga0123461_RS11625	COG0405	Gamma-glutamyltransferase
Ga0123461_RS11650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ga0123461_RS11660	COG0785	Cytochrome C biogenesis protein
Ga0123461_RS11680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Ga0123461_RS11685	COG1692	metallophosphoesterase
Ga0123461_RS11700	COG1610	YqeY-like protein
Ga0123461_RS11705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Ga0123461_RS11710	COG0728	peptidoglycan biosynthetic process
Ga0123461_RS11725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ga0123461_RS11730	COG0512	Glutamine amidotransferase of anthranilate synthase
Ga0123461_RS11735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ga0123461_RS11740	COG0134	indole-3-glycerol-phosphate synthase activity
Ga0123461_RS11770	COG0457	Tetratricopeptide repeat
Ga0123461_RS11785	COG1940	carbohydrate kinase activity
Ga0123461_RS11795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Ga0123461_RS11800	COG0509	glycine decarboxylation via glycine cleavage system
Ga0123461_RS11805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ga0123461_RS11810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ga0123461_RS11830	COG0436	Aminotransferase
Ga0123461_RS11835	COG0653	protein targeting
Ga0123461_RS11840	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Ga0123461_RS11845	COG0494	nUDIX hydrolase
Ga0123461_RS11855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Ga0123461_RS11860	COG2199	diguanylate cyclase activity
Ga0123461_RS11875	COG0793	Belongs to the peptidase S41A family
Ga0123461_RS11880	COG4942	peptidase
Ga0123461_RS11880	COG1388	LysM domain
Ga0123461_RS11885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Ga0123461_RS11890	COG0799	negative regulation of ribosome biogenesis
Ga0123461_RS11895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Ga0123461_RS11900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Ga0123461_RS11905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Ga0123461_RS11910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ga0123461_RS11915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Ga0123461_RS11920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Ga0123461_RS11925	COG0254	rRNA binding
Ga0123461_RS11930	COG0346	lactoylglutathione lyase activity
Ga0123461_RS11945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ga0123461_RS11960	COG1918	ferrous iron import across plasma membrane
Ga0123461_RS11960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ga0123461_RS11975	COG0475	glutathione-regulated potassium exporter activity
Ga0123461_RS11985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Ga0123461_RS11990	COG0798	PFAM Bile acid sodium symporter
Ga0123461_RS12000	COG0640	Transcriptional regulator
Ga0123461_RS12005	COG0589	response to stress
Ga0123461_RS12010	COG0137	argininosuccinate synthase activity
Ga0123461_RS12015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Ga0123461_RS12020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ga0123461_RS12030	COG0133	tryptophan synthase activity
Ga0123461_RS12035	COG0159	tryptophan synthase activity
Ga0123461_RS12045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Ga0123461_RS12050	COG0285	dihydrofolate synthase activity
Ga0123461_RS12055	COG0745	RESPONSE REGULATOR receiver
Ga0123461_RS12065	COG0028	Belongs to the TPP enzyme family
Ga0123461_RS12080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ga0123461_RS12095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ga0123461_RS12110	COG2967	ApaG domain
Ga0123461_RS12120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Ga0123461_RS12125	COG0085	RNA polymerase activity
Ga0123461_RS12130	COG0222	ribosome binding
Ga0123461_RS12135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Ga0123461_RS12140	COG0081	regulation of translation
Ga0123461_RS12145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Ga0123461_RS12155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ga0123461_RS12165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Ga0123461_RS12170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ga0123461_RS12200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ga0123461_RS12215	COG1475	DNA binding
Ga0123461_RS12225	COG0357	Ribosomal RNA small subunit methyltransferase G
Ga0123461_RS12230	COG0445	tRNA wobble uridine modification
Ga0123461_RS12240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ga0123461_RS12245	COG0706	membrane insertase activity
Ga0123461_RS12250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Ga0123461_RS12260	COG0230	Belongs to the bacterial ribosomal protein bL34 family