locus-tag	class	description
E1742_RS00005	COG0215	cysteine-tRNA ligase activity
E1742_RS00015	COG0825	malonyl-CoA metabolic process
E1742_RS00020	COG0037	tRNA processing
E1742_RS00025	COG0527	aspartate kinase activity
E1742_RS00095	COG3300	MHYT domain
E1742_RS00095	COG5001	Diguanylate cyclase
E1742_RS00100	COG1309	transcriptional regulator
E1742_RS00120	COG2271	Major facilitator Superfamily
E1742_RS00125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1742_RS00145	COG4771	TonB-dependent receptor
E1742_RS00155	COG0840	transmembrane signaling receptor activity
E1742_RS00200	COG1234	tRNA 3'-trailer cleavage
E1742_RS00225	COG4771	TonB-dependent receptor
E1742_RS00260	COG3634	alkyl hydroperoxide reductase activity
E1742_RS00270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E1742_RS00280	COG1522	sequence-specific DNA binding
E1742_RS00305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E1742_RS00310	COG0494	nUDIX hydrolase
E1742_RS00335	COG2205	protein histidine kinase activity
E1742_RS00355	COG4948	Mandelate Racemase Muconate Lactonizing
E1742_RS00360	COG0583	DNA-binding transcription factor activity
E1742_RS00370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E1742_RS00395	COG1252	NADH dehydrogenase
E1742_RS00400	COG3850	Histidine kinase
E1742_RS00410	COG5002	protein histidine kinase activity
E1742_RS00425	COG0784	Response regulator, receiver
E1742_RS00425	COG2205	protein histidine kinase activity
E1742_RS00460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E1742_RS00480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS00495	COG1496	oxidoreductase activity
E1742_RS00500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1742_RS00505	COG0477	Major facilitator Superfamily
E1742_RS00520	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E1742_RS00525	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS00560	COG0829	nickel cation binding
E1742_RS00570	COG0832	Belongs to the urease beta subunit family
E1742_RS00575	COG0804	urea catabolic process
E1742_RS00580	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E1742_RS00585	COG0830	nickel cation binding
E1742_RS00590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E1742_RS00605	COG1902	pentaerythritol trinitrate reductase activity
E1742_RS00650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E1742_RS00660	COG0688	phosphatidylethanolamine metabolic process
E1742_RS00710	COG4221	oxidoreductase activity
E1742_RS00720	COG1418	mRNA catabolic process
E1742_RS00730	COG0840	transmembrane signaling receptor activity
E1742_RS00785	COG0515	serine threonine protein kinase
E1742_RS00800	COG1741	Belongs to the pirin family
E1742_RS00880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E1742_RS00910	COG0038	chloride channel
E1742_RS00925	COG4771	TonB-dependent receptor
E1742_RS00940	COG3433	isochorismatase activity
E1742_RS00940	COG1535	isochorismatase
E1742_RS00945	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS00955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E1742_RS00975	COG2382	esterase
E1742_RS00985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E1742_RS01010	COG4774	siderophore transport
E1742_RS01030	COG0784	Response regulator, receiver
E1742_RS01030	COG2205	protein histidine kinase activity
E1742_RS01030	COG5002	protein histidine kinase activity
E1742_RS01065	COG1126	abc transporter atp-binding protein
E1742_RS01120	COG1940	carbohydrate kinase activity
E1742_RS01125	COG2382	esterase
E1742_RS01125	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS01125	COG3693	PFAM glycoside hydrolase, family 10
E1742_RS01130	COG1864	DNA RNA non-specific endonuclease
E1742_RS01130	COG3591	Belongs to the peptidase S1B family
E1742_RS01150	COG3706	GGDEF domain
E1742_RS01150	COG4251	negative regulation of phosphorylation
E1742_RS01150	COG2203	Gaf domain
E1742_RS01150	COG5001	Diguanylate cyclase
E1742_RS01160	COG0784	Response regulator, receiver
E1742_RS01160	COG4191	Histidine kinase
E1742_RS01180	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E1742_RS01220	COG0626	cystathionine gamma-synthase activity
E1742_RS01225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E1742_RS01230	COG1435	thymidine kinase activity
E1742_RS01245	COG2080	2 iron, 2 sulfur cluster binding
E1742_RS01250	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E1742_RS01255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E1742_RS01260	COG0656	L-ascorbic acid biosynthetic process
E1742_RS01265	COG0753	catalase activity
E1742_RS01300	COG1960	acyl-CoA dehydrogenase activity
E1742_RS01310	COG0778	Nitroreductase
E1742_RS01325	COG3411	Ferredoxin
E1742_RS01350	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E1742_RS01385	COG1960	acyl-CoA dehydrogenase activity
E1742_RS01440	COG1459	type II secretion system
E1742_RS01460	COG3267	Type II secretory pathway component ExeA
E1742_RS01460	COG3409	Peptidoglycan-binding domain 1 protein
E1742_RS01465	COG1131	(ABC) transporter
E1742_RS01475	COG1459	type II secretion system
E1742_RS01485	COG2165	general secretion pathway protein
E1742_RS01545	COG3409	Peptidoglycan-binding domain 1 protein
E1742_RS01545	COG3267	Type II secretory pathway component ExeA
E1742_RS01565	COG2204	response regulator
E1742_RS01600	COG0436	Aminotransferase
E1742_RS01610	COG3022	response to hydroperoxide
E1742_RS01615	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E1742_RS01625	COG0564	pseudouridine synthase activity
E1742_RS01645	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E1742_RS01655	COG2723	6-phospho-beta-galactosidase activity
E1742_RS01665	COG1175	transmembrane transport
E1742_RS01675	COG3842	ATPase activity
E1742_RS01685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E1742_RS01690	COG0626	cystathionine gamma-synthase activity
E1742_RS01720	COG0560	Phosphoserine phosphatase
E1742_RS01725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E1742_RS01745	COG0515	serine threonine protein kinase
E1742_RS01745	COG2815	serine threonine protein kinase
E1742_RS01855	COG1611	Belongs to the LOG family
E1742_RS01875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E1742_RS01900	COG0583	DNA-binding transcription factor activity
E1742_RS01905	COG3739	integral membrane protein
E1742_RS01960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E1742_RS01975	COG4591	ABC-type transport system involved in lipoprotein release permease component
E1742_RS01980	COG1136	(ABC) transporter
E1742_RS01985	COG0084	hydrolase, TatD family'
E1742_RS02000	COG2271	Major facilitator Superfamily
E1742_RS02005	COG1609	Transcriptional regulator
E1742_RS02035	COG2267	carboxylic ester hydrolase activity
E1742_RS02040	COG0717	Belongs to the dCTP deaminase family
E1742_RS02050	COG0745	RESPONSE REGULATOR receiver
E1742_RS02145	COG0693	protein deglycase activity
E1742_RS02155	COG0513	Belongs to the DEAD box helicase family
E1742_RS02165	COG1132	(ABC) transporter
E1742_RS02185	COG0277	FAD linked oxidase domain protein
E1742_RS02200	COG1295	ribonuclease BN
E1742_RS02215	COG3385	transposase activity
E1742_RS02225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E1742_RS02250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E1742_RS02260	COG1278	Cold shock
E1742_RS02265	COG0583	DNA-binding transcription factor activity
E1742_RS02270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E1742_RS02280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1742_RS02285	COG2226	methyltransferase
E1742_RS02290	COG0328	RNA-DNA hybrid ribonuclease activity
E1742_RS02310	COG0673	inositol 2-dehydrogenase activity
E1742_RS02460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E1742_RS02535	COG5002	protein histidine kinase activity
E1742_RS02545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E1742_RS02550	COG0243	molybdopterin cofactor binding
E1742_RS02565	COG1132	(ABC) transporter
E1742_RS02570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E1742_RS02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
E1742_RS02575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E1742_RS02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
E1742_RS02590	COG0443	Heat shock 70 kDa protein
E1742_RS02595	COG2176	DNA-directed DNA polymerase activity
E1742_RS02615	COG1505	serine-type exopeptidase activity
E1742_RS02620	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E1742_RS02625	COG5001	Diguanylate cyclase
E1742_RS02625	COG3706	GGDEF domain
E1742_RS02625	COG4251	negative regulation of phosphorylation
E1742_RS02625	COG2203	Gaf domain
E1742_RS02630	COG3851	Histidine kinase
E1742_RS02635	COG0602	queuosine metabolic process
E1742_RS02640	COG0720	synthase
E1742_RS02650	COG1619	proteins homologs of microcin C7 resistance protein MccF
E1742_RS02660	COG0488	(ABC) transporter
E1742_RS02665	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E1742_RS02680	COG0183	Belongs to the thiolase family
E1742_RS02695	COG2130	NADP-dependent
E1742_RS02700	COG2153	protein acetylation
E1742_RS02705	COG0583	DNA-binding transcription factor activity
E1742_RS02710	COG0604	alcohol dehydrogenase
E1742_RS02740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E1742_RS02745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E1742_RS02760	COG1247	-acetyltransferase
E1742_RS02765	COG0084	hydrolase, TatD family'
E1742_RS02775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E1742_RS02825	COG4104	PAAR repeat-containing protein
E1742_RS02830	COG0826	peptidase U32
E1742_RS02845	COG0489	protein tyrosine kinase activity
E1742_RS02910	COG1305	Transglutaminase-like
E1742_RS02920	COG2308	Evidence 4 Homologs of previously reported genes of
E1742_RS02925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E1742_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS02970	COG4974	Belongs to the 'phage' integrase family
E1742_RS02975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E1742_RS02975	COG2755	lipolytic protein G-D-S-L family
E1742_RS02995	COG2391	methyltransferase activity
E1742_RS03010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E1742_RS03015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E1742_RS03020	COG0431	NADPH-dependent FMN reductase
E1742_RS03040	COG2204	response regulator
E1742_RS03050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E1742_RS03055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E1742_RS03070	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS03075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E1742_RS03080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E1742_RS03085	COG2917	probably involved in intracellular septation
E1742_RS03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E1742_RS03100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E1742_RS03105	COG3385	transposase activity
E1742_RS03115	COG0583	DNA-binding transcription factor activity
E1742_RS03120	COG0047	phosphoribosylformylglycinamidine synthase activity
E1742_RS03120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E1742_RS03150	COG4181	ATPase activity
E1742_RS03160	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E1742_RS03165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E1742_RS03175	COG0776	regulation of translation
E1742_RS03180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E1742_RS03190	COG0740	serine-type endopeptidase activity
E1742_RS03205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E1742_RS03210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS03220	COG1562	ergosterol biosynthetic process
E1742_RS03310	COG4974	Belongs to the 'phage' integrase family
E1742_RS03320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E1742_RS03325	COG0303	'Molybdopterin
E1742_RS03335	COG1760	l-serine dehydratase
E1742_RS03340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E1742_RS03345	COG0156	8-amino-7-oxononanoate synthase activity
E1742_RS03400	COG4133	protoheme IX ABC transporter activity
E1742_RS03420	COG1446	asparaginase
E1742_RS03430	COG1181	Belongs to the D-alanine--D-alanine ligase family
E1742_RS03430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E1742_RS03435	COG0784	Response regulator, receiver
E1742_RS03435	COG2205	protein histidine kinase activity
E1742_RS03445	COG3706	GGDEF domain
E1742_RS03460	COG2252	PERMEase
E1742_RS03465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E1742_RS03500	COG0657	acetylesterase activity
E1742_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS03540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E1742_RS03550	COG0045	succinate-CoA ligase (ADP-forming) activity
E1742_RS03550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E1742_RS03550	COG1042	CoA-binding domain protein
E1742_RS03555	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E1742_RS03570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E1742_RS03575	COG1845	cytochrome c oxidase, subunit III
E1742_RS03580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E1742_RS03585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E1742_RS03590	COG0477	Major facilitator Superfamily
E1742_RS03595	COG1301	dicarboxylic acid transport
E1742_RS03625	COG0840	transmembrane signaling receptor activity
E1742_RS03635	COG1113	amino acid transport
E1742_RS03640	COG5001	Diguanylate cyclase
E1742_RS03640	COG4251	negative regulation of phosphorylation
E1742_RS03640	COG3706	GGDEF domain
E1742_RS03640	COG2203	Gaf domain
E1742_RS03655	COG5001	Diguanylate cyclase
E1742_RS03675	COG0531	amino acid
E1742_RS03680	COG2197	response regulator
E1742_RS03690	COG3916	Acyl-homoserine-lactone synthase
E1742_RS03710	COG2197	response regulator
E1742_RS03760	COG5001	Diguanylate cyclase
E1742_RS03760	COG3300	MHYT domain
E1742_RS03780	COG0395	ABC-type sugar transport system, permease component
E1742_RS03785	COG1175	transmembrane transport
E1742_RS03795	COG3250	beta-galactosidase activity
E1742_RS03805	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS03810	COG1472	Belongs to the glycosyl hydrolase 3 family
E1742_RS03835	COG0668	transmembrane transport
E1742_RS03850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E1742_RS03860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E1742_RS03870	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E1742_RS03885	COG2833	Protein of unknown function (DUF455)
E1742_RS03895	COG2351	hydroxyisourate hydrolase activity
E1742_RS03910	COG0745	RESPONSE REGULATOR receiver
E1742_RS03940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E1742_RS04005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E1742_RS04015	COG4794	Type iii secretion
E1742_RS04040	COG1157	protein secretion by the type III secretion system
E1742_RS04060	COG4789	Type iii secretion
E1742_RS04100	COG0500	methyltransferase
E1742_RS04140	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS04155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E1742_RS04160	COG1085	galactose-1-phosphate uridylyltransferase
E1742_RS04205	COG1129	ABC transporter
E1742_RS04210	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1742_RS04215	COG1879	ABC-type sugar transport system periplasmic component
E1742_RS04225	COG0673	inositol 2-dehydrogenase activity
E1742_RS04245	COG3604	Transcriptional regulator
E1742_RS04255	COG0515	serine threonine protein kinase
E1742_RS04320	COG0475	glutathione-regulated potassium exporter activity
E1742_RS04330	COG2814	Major facilitator Superfamily
E1742_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS04480	COG2113	Glycine betaine
E1742_RS04485	COG4176	ABC-type proline glycine betaine transport system permease component
E1742_RS04490	COG4175	Glycine betaine
E1742_RS04505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E1742_RS04510	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E1742_RS04520	COG0535	radical SAM domain protein
E1742_RS04525	COG3162	membrane
E1742_RS04530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E1742_RS04545	COG0596	Alpha beta hydrolase
E1742_RS04550	COG1309	transcriptional regulator
E1742_RS04555	COG1944	ATP diphosphatase activity
E1742_RS04560	COG0583	DNA-binding transcription factor activity
E1742_RS04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E1742_RS04630	COG4771	TonB-dependent receptor
E1742_RS04640	COG0640	Transcriptional regulator
E1742_RS04655	COG1228	amidohydrolase
E1742_RS04660	COG2207	Transcriptional regulator
E1742_RS04660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E1742_RS04665	COG1335	isochorismatase
E1742_RS04670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E1742_RS04670	COG0519	Catalyzes the synthesis of GMP from XMP
E1742_RS04675	COG0516	GMP reductase activity
E1742_RS04675	COG0517	IMP dehydrogenase activity
E1742_RS04695	COG2914	Belongs to the UPF0125 (RnfH) family
E1742_RS04700	COG2867	negative regulation of translational initiation
E1742_RS04705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E1742_RS04740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E1742_RS04745	COG1335	isochorismatase
E1742_RS04750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E1742_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS04790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E1742_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS04805	COG1595	DNA-templated transcription, initiation
E1742_RS04810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E1742_RS04815	COG2202	Pas domain
E1742_RS04815	COG2200	EAL domain
E1742_RS04815	COG2199	diguanylate cyclase activity
E1742_RS04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E1742_RS04825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E1742_RS04830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E1742_RS04835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E1742_RS04840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E1742_RS04845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E1742_RS04850	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E1742_RS04855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E1742_RS04860	COG0750	zinc metalloprotease
E1742_RS04865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E1742_RS04870	COG0575	Belongs to the CDS family
E1742_RS04875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E1742_RS04880	COG0233	cytoplasmic translational termination
E1742_RS04885	COG0528	UMP kinase activity
E1742_RS04890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E1742_RS04895	COG0052	Belongs to the universal ribosomal protein uS2 family
E1742_RS04925	COG0024	Methionine aminopeptidase
E1742_RS04930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E1742_RS04935	COG1187	pseudouridine synthase activity
E1742_RS04945	COG1297	OPT oligopeptide transporter protein
E1742_RS04950	COG0242	peptide deformylase activity
E1742_RS04955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E1742_RS04960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E1742_RS04990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E1742_RS04995	COG0509	glycine decarboxylation via glycine cleavage system
E1742_RS05000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E1742_RS05000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E1742_RS05015	COG2319	Wd-40 repeat
E1742_RS05015	COG4249	Peptidase C14 caspase catalytic subunit p20
E1742_RS05060	COG1131	(ABC) transporter
E1742_RS05065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E1742_RS05070	COG1819	glycosyl
E1742_RS05075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E1742_RS05115	COG0642	Histidine kinase
E1742_RS05125	COG0840	transmembrane signaling receptor activity
E1742_RS05140	COG2197	response regulator
E1742_RS05150	COG0776	regulation of translation
E1742_RS05155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E1742_RS05155	COG0072	phenylalanine-tRNA ligase activity
E1742_RS05160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E1742_RS05165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E1742_RS05170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E1742_RS05175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E1742_RS05180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E1742_RS05200	COG1230	cation diffusion facilitator family transporter
E1742_RS05215	COG1335	isochorismatase
E1742_RS05240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E1742_RS05245	COG0251	oxidation-reduction process
E1742_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS05260	COG0387	Pfam Sodium calcium exchanger
E1742_RS05265	COG4771	TonB-dependent receptor
E1742_RS05275	COG1301	dicarboxylic acid transport
E1742_RS05325	COG4566	intracellular signal transduction
E1742_RS05330	COG0251	oxidation-reduction process
E1742_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS05375	COG0110	maltose O-acetyltransferase activity
E1742_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS05385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E1742_RS05395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E1742_RS05410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E1742_RS05415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E1742_RS05420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E1742_RS05450	COG0673	inositol 2-dehydrogenase activity
E1742_RS05455	COG4702	Belongs to the UPF0303 family
E1742_RS05460	COG1349	DNA-binding transcription factor activity
E1742_RS05485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E1742_RS05490	COG0668	transmembrane transport
E1742_RS05505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E1742_RS05525	COG1987	bacterial-type flagellum assembly
E1742_RS05535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1742_RS05545	COG1677	Flagellar hook-basal body complex protein FliE
E1742_RS05555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1742_RS05600	COG1191	sigma factor activity
E1742_RS05605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E1742_RS05625	COG1705	Flagellar rod assembly protein muramidase FlgJ
E1742_RS05625	COG3951	Flagellar rod assembly protein muramidase FlgJ
E1742_RS05645	COG1558	bacterial-type flagellum-dependent cell motility
E1742_RS05665	COG4786	Flagellar basal body rod
E1742_RS05670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E1742_RS05675	COG1706	bacterial-type flagellum-dependent cell motility
E1742_RS05700	COG5001	Diguanylate cyclase
E1742_RS05725	COG0121	glutamine amidotransferase
E1742_RS05730	COG0772	Belongs to the SEDS family
E1742_RS05745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E1742_RS05745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E1742_RS05750	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E1742_RS05760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E1742_RS05765	COG1074	ATP-dependent DNA helicase activity
E1742_RS05770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E1742_RS05790	COG1505	serine-type exopeptidase activity
E1742_RS05795	COG0784	Response regulator, receiver
E1742_RS05795	COG2205	protein histidine kinase activity
E1742_RS05810	COG0625	glutathione transferase activity
E1742_RS05815	COG0840	transmembrane signaling receptor activity
E1742_RS05825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E1742_RS05840	COG0784	Response regulator, receiver
E1742_RS05840	COG3437	response regulator, receiver
E1742_RS05860	COG2059	Chromate
E1742_RS05875	COG1045	serine acetyltransferase
E1742_RS05880	COG2814	Major facilitator Superfamily
E1742_RS05900	COG3118	belongs to the thioredoxin family
E1742_RS05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E1742_RS05960	COG1122	ATPase activity
E1742_RS05965	COG4662	Binding-protein-dependent transport system inner membrane component
E1742_RS05970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E1742_RS05975	COG3383	formate dehydrogenase (NAD+) activity
E1742_RS05985	COG1910	domain protein
E1742_RS06000	COG2135	peptidase activity
E1742_RS06015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E1742_RS06050	COG3546	catalase activity
E1742_RS06055	COG1960	acyl-CoA dehydrogenase activity
E1742_RS06060	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS06070	COG0559	Belongs to the binding-protein-dependent transport system permease family
E1742_RS06115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E1742_RS06130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E1742_RS06140	COG0835	chemotaxis
E1742_RS06140	COG0784	Response regulator, receiver
E1742_RS06150	COG0025	NhaP-type Na H and K H
E1742_RS06155	COG3275	phosphorelay sensor kinase activity
E1742_RS06160	COG3279	Response regulator of the LytR AlgR family
E1742_RS06180	COG3706	GGDEF domain
E1742_RS06195	COG2205	protein histidine kinase activity
E1742_RS06215	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1742_RS06220	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1742_RS06225	COG1129	ABC transporter
E1742_RS06230	COG1879	ABC-type sugar transport system periplasmic component
E1742_RS06240	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS06245	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS06255	COG1082	Xylose isomerase domain protein TIM barrel
E1742_RS06285	COG3940	Belongs to the glycosyl hydrolase 43 family
E1742_RS06290	COG2211	Major facilitator Superfamily
E1742_RS06315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E1742_RS06320	COG5002	protein histidine kinase activity
E1742_RS06325	COG0534	Mate efflux family protein
E1742_RS06340	COG4771	TonB-dependent receptor
E1742_RS06365	COG0417	DNA replication proofreading
E1742_RS06380	COG0662	Cupin 2, conserved barrel domain protein
E1742_RS06405	COG1278	Cold shock
E1742_RS06415	COG1472	Belongs to the glycosyl hydrolase 3 family
E1742_RS06420	COG1501	Belongs to the glycosyl hydrolase 31 family
E1742_RS06425	COG1874	Beta-galactosidase
E1742_RS06445	COG4213	ABC transporter substrate-binding protein
E1742_RS06450	COG2017	converts alpha-aldose to the beta-anomer
E1742_RS06455	COG1609	Transcriptional regulator
E1742_RS06455	COG2207	Transcriptional regulator
E1742_RS06460	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS06465	COG4585	Histidine kinase
E1742_RS06470	COG2197	response regulator
E1742_RS06495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1742_RS06500	COG1609	Transcriptional regulator
E1742_RS06505	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1742_RS06510	COG1129	ABC transporter
E1742_RS06515	COG1879	ABC-type sugar transport system periplasmic component
E1742_RS06520	COG2897	thiosulfate sulfurtransferase activity
E1742_RS06555	COG0322	excinuclease ABC activity
E1742_RS06560	COG0736	holo-[acyl-carrier-protein] synthase activity
E1742_RS06565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E1742_RS06575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E1742_RS06595	COG0481	GTPase activity
E1742_RS06605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E1742_RS06630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E1742_RS06645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E1742_RS06650	COG0416	fatty acid biosynthetic process
E1742_RS06655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E1742_RS06660	COG1399	metal-binding, possibly nucleic acid-binding protein
E1742_RS06665	COG0424	maF-like protein
E1742_RS06670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E1742_RS06675	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E1742_RS06680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E1742_RS06685	COG2224	Isocitrate lyase
E1742_RS06690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E1742_RS06740	COG0542	response to heat
E1742_RS06745	COG0314	molybdopterin synthase activity
E1742_RS06760	COG0045	succinate-CoA ligase (ADP-forming) activity
E1742_RS06760	COG1042	CoA-binding domain protein
E1742_RS06760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E1742_RS06770	COG3214	Protein conserved in bacteria
E1742_RS06775	COG0420	3'-5' exonuclease activity
E1742_RS06800	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E1742_RS06825	COG0513	Belongs to the DEAD box helicase family
E1742_RS06830	COG0154	amidase activity
E1742_RS06835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E1742_RS06890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E1742_RS06905	COG0489	protein tyrosine kinase activity
E1742_RS06910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E1742_RS06910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E1742_RS06920	COG0697	spore germination
E1742_RS06930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E1742_RS06935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E1742_RS06940	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E1742_RS06945	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E1742_RS06950	COG0745	RESPONSE REGULATOR receiver
E1742_RS06955	COG2201	protein-glutamate methylesterase activity
E1742_RS06960	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E1742_RS06975	COG0835	chemotaxis
E1742_RS06980	COG0643	Histidine kinase
E1742_RS06980	COG2198	Histidine kinase
E1742_RS06985	COG0745	RESPONSE REGULATOR receiver
E1742_RS06995	COG1360	Flagellar Motor Protein
E1742_RS07005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E1742_RS07025	COG3483	tryptophan 2,3-dioxygenase activity
E1742_RS07035	COG4251	negative regulation of phosphorylation
E1742_RS07040	COG0784	Response regulator, receiver
E1742_RS07080	COG0697	spore germination
E1742_RS07090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E1742_RS07100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E1742_RS07105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E1742_RS07110	COG0277	FAD linked oxidase domain protein
E1742_RS07135	COG0612	Peptidase, M16
E1742_RS07140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E1742_RS07145	COG0477	Major facilitator Superfamily
E1742_RS07180	COG0513	Belongs to the DEAD box helicase family
E1742_RS07200	COG1280	lysine exporter protein (LysE YggA)
E1742_RS07220	COG2171	N-acyltransferase activity
E1742_RS07265	COG1393	Belongs to the ArsC family
E1742_RS07275	COG2890	protein-(glutamine-N5) methyltransferase activity
E1742_RS07280	COG0488	(ABC) transporter
E1742_RS07325	COG4941	Belongs to the sigma-70 factor family
E1742_RS07330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E1742_RS07360	COG3201	nicotinamide mononucleotide transporter
E1742_RS07380	COG2205	protein histidine kinase activity
E1742_RS07385	COG5001	Diguanylate cyclase
E1742_RS07390	COG4990	cell redox homeostasis
E1742_RS07390	COG3591	Belongs to the peptidase S1B family
E1742_RS07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS07420	COG1278	Cold shock
E1742_RS07430	COG0616	signal peptide processing
E1742_RS07440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E1742_RS07455	COG2814	Major facilitator Superfamily
E1742_RS07460	COG3530	Putative quorum-sensing-regulated virulence factor
E1742_RS07465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E1742_RS07485	COG0583	DNA-binding transcription factor activity
E1742_RS07490	COG1741	Belongs to the pirin family
E1742_RS07495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E1742_RS07560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E1742_RS07565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E1742_RS07585	COG1007	ATP synthesis coupled electron transport
E1742_RS07600	COG0713	ATP synthesis coupled electron transport
E1742_RS07610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1742_RS07615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E1742_RS07620	COG1034	ATP synthesis coupled electron transport
E1742_RS07630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E1742_RS07635	COG0649	NAD binding
E1742_RS07640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1742_RS07650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1742_RS07660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E1742_RS07665	COG0149	triose-phosphate isomerase activity
E1742_RS07670	COG0604	alcohol dehydrogenase
E1742_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS07670	COG3321	synthase
E1742_RS07705	COG4771	TonB-dependent receptor
E1742_RS07710	COG2755	lipolytic protein G-D-S-L family
E1742_RS07720	COG3345	alpha-galactosidase
E1742_RS07755	COG0840	transmembrane signaling receptor activity
E1742_RS07770	COG1185	polyribonucleotide nucleotidyltransferase activity
E1742_RS07775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E1742_RS07785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E1742_RS07790	COG1183	phosphatidylcholine synthase activity
E1742_RS07810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E1742_RS07815	COG0440	acetolactate synthase activity
E1742_RS07820	COG0028	Belongs to the TPP enzyme family
E1742_RS07855	COG2814	Major facilitator Superfamily
E1742_RS07870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E1742_RS07880	COG2975	iron-sulfur cluster assembly
E1742_RS07890	COG0443	Heat shock 70 kDa protein
E1742_RS07895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E1742_RS07900	COG0316	Belongs to the HesB IscA family
E1742_RS07905	COG0822	iron-sulfur transferase activity
E1742_RS07910	COG1104	cysteine desulfurase activity
E1742_RS07930	COG0625	glutathione transferase activity
E1742_RS07940	COG0583	DNA-binding transcription factor activity
E1742_RS07960	COG0443	Heat shock 70 kDa protein
E1742_RS07965	COG0443	Heat shock 70 kDa protein
E1742_RS07975	COG0840	transmembrane signaling receptor activity
E1742_RS08070	COG0693	protein deglycase activity
E1742_RS08100	COG3275	phosphorelay sensor kinase activity
E1742_RS08110	COG2610	gluconate transmembrane transporter activity
E1742_RS08120	COG2755	lipolytic protein G-D-S-L family
E1742_RS08120	COG0657	acetylesterase activity
E1742_RS08145	COG0556	nucleotide-excision repair
E1742_RS08155	COG0640	Transcriptional regulator
E1742_RS08170	COG2095	MarC family integral membrane protein
E1742_RS08175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E1742_RS08180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E1742_RS08185	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E1742_RS08190	COG0330	HflC and HflK could
E1742_RS08195	COG0330	HflC and HflK could
E1742_RS08200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E1742_RS08205	COG1923	regulation of RNA biosynthetic process
E1742_RS08210	COG1160	GTP binding
E1742_RS08225	COG0124	histidyl-tRNA synthetase
E1742_RS08230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E1742_RS08235	COG1426	Protein conserved in bacteria
E1742_RS08245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E1742_RS08250	COG0105	UTP biosynthetic process
E1742_RS08265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E1742_RS08285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E1742_RS08300	COG1199	ATP-dependent helicase activity
E1742_RS08320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E1742_RS08325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E1742_RS08335	COG0508	dehydrogenase complex catalyzes the overall conversion of
E1742_RS08340	COG0567	Dehydrogenase, E1 component
E1742_RS08355	COG5002	protein histidine kinase activity
E1742_RS08370	COG2205	protein histidine kinase activity
E1742_RS08370	COG2202	Pas domain
E1742_RS08375	COG5002	protein histidine kinase activity
E1742_RS08380	COG2205	protein histidine kinase activity
E1742_RS08380	COG3292	Two component regulator propeller
E1742_RS08380	COG0745	RESPONSE REGULATOR receiver
E1742_RS08385	COG5002	protein histidine kinase activity
E1742_RS08395	COG0372	Belongs to the citrate synthase family
E1742_RS08400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E1742_RS08405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E1742_RS08410	COG1053	succinate dehydrogenase
E1742_RS08415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E1742_RS08420	COG2009	succinate dehydrogenase
E1742_RS08445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E1742_RS08475	COG2866	Carboxypeptidase
E1742_RS08480	COG0753	catalase activity
E1742_RS08500	COG0427	acetyl-CoA hydrolase
E1742_RS08505	COG0583	DNA-binding transcription factor activity
E1742_RS08550	COG0740	serine-type endopeptidase activity
E1742_RS08610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E1742_RS08620	COG1309	transcriptional regulator
E1742_RS08640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS08655	COG0477	Major facilitator Superfamily
E1742_RS08680	COG2205	protein histidine kinase activity
E1742_RS08690	COG2204	response regulator
E1742_RS08710	COG0436	Aminotransferase
E1742_RS08720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E1742_RS08725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E1742_RS08745	COG0789	Transcriptional regulator
E1742_RS08750	COG2217	Heavy metal translocating P-type atpase
E1742_RS08780	COG3437	response regulator, receiver
E1742_RS08815	COG1396	sequence-specific DNA binding
E1742_RS08825	COG0306	phosphate transporter
E1742_RS08835	COG0305	Participates in initiation and elongation during chromosome replication
E1742_RS08840	COG0359	binds to the 23S rRNA
E1742_RS08845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E1742_RS08855	COG0360	Binds together with S18 to 16S ribosomal RNA
E1742_RS08860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E1742_RS08870	COG0626	cystathionine gamma-synthase activity
E1742_RS08890	COG0285	dihydrofolate synthase activity
E1742_RS08895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E1742_RS08900	COG0159	tryptophan synthase activity
E1742_RS08905	COG0133	tryptophan synthase activity
E1742_RS08910	COG0135	phosphoribosylanthranilate isomerase activity
E1742_RS08915	COG0101	tRNA pseudouridine synthase activity
E1742_RS08925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E1742_RS08930	COG0473	3-isopropylmalate dehydrogenase activity
E1742_RS08935	COG0066	3-isopropylmalate dehydratase activity
E1742_RS08945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E1742_RS08950	COG2198	Histidine kinase
E1742_RS08950	COG0784	Response regulator, receiver
E1742_RS08950	COG0643	Histidine kinase
E1742_RS08955	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E1742_RS08990	COG4206	TonB-dependent receptor
E1742_RS09000	COG1477	protein flavinylation
E1742_RS09040	COG1201	RNA secondary structure unwinding
E1742_RS09045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E1742_RS09045	COG1793	dna ligase
E1742_RS09050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E1742_RS09050	COG1793	dna ligase
E1742_RS09055	COG0514	ATP-dependent DNA helicase (RecQ)
E1742_RS09065	COG0784	Response regulator, receiver
E1742_RS09065	COG4191	Histidine kinase
E1742_RS09070	COG2205	protein histidine kinase activity
E1742_RS09075	COG0667	Aldo Keto reductase
E1742_RS09085	COG1956	GAF domain-containing protein
E1742_RS09095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E1742_RS09105	COG2207	Transcriptional regulator
E1742_RS09110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E1742_RS09145	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E1742_RS09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E1742_RS09160	COG0180	Tryptophanyl-tRNA synthetase
E1742_RS09165	COG1994	Peptidase M50
E1742_RS09170	COG0009	L-threonylcarbamoyladenylate synthase
E1742_RS09175	COG0501	Belongs to the peptidase M48B family
E1742_RS09180	COG0613	PHP domain protein
E1742_RS09185	COG0596	Alpha beta hydrolase
E1742_RS09195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E1742_RS09225	COG0584	glycerophosphoryl diester phosphodiesterase
E1742_RS09255	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E1742_RS09260	COG0148	phosphopyruvate hydratase activity
E1742_RS09270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E1742_RS09275	COG0504	CTP synthase activity
E1742_RS09305	COG0587	DNA-directed DNA polymerase activity
E1742_RS09320	COG0737	Belongs to the 5'-nucleotidase family
E1742_RS09330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E1742_RS09335	COG0642	Histidine kinase
E1742_RS09345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E1742_RS09355	COG0071	Belongs to the small heat shock protein (HSP20) family
E1742_RS09400	COG1643	Atp-dependent helicase
E1742_RS09405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E1742_RS09405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E1742_RS09410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E1742_RS09415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E1742_RS09420	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E1742_RS09435	COG2203	Gaf domain
E1742_RS09435	COG3706	GGDEF domain
E1742_RS09435	COG5001	Diguanylate cyclase
E1742_RS09435	COG4251	negative regulation of phosphorylation
E1742_RS09445	COG2201	protein-glutamate methylesterase activity
E1742_RS09455	COG0835	chemotaxis
E1742_RS09465	COG0840	transmembrane signaling receptor activity
E1742_RS09465	COG3290	protein histidine kinase activity
E1742_RS09470	COG2198	Histidine kinase
E1742_RS09470	COG0643	Histidine kinase
E1742_RS09480	COG0745	RESPONSE REGULATOR receiver
E1742_RS09485	COG0840	transmembrane signaling receptor activity
E1742_RS09520	COG0800	Aldolase
E1742_RS09530	COG0166	Belongs to the GPI family
E1742_RS09540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E1742_RS09550	COG2205	protein histidine kinase activity
E1742_RS09550	COG2202	Pas domain
E1742_RS09555	COG2814	Major facilitator Superfamily
E1742_RS09570	COG3842	ATPase activity
E1742_RS09580	COG1840	ABC-type Fe3 transport system, periplasmic component
E1742_RS09590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E1742_RS09620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E1742_RS09625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS09630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E1742_RS09645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E1742_RS09650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E1742_RS09665	COG3266	domain, Protein
E1742_RS09665	COG0515	serine threonine protein kinase
E1742_RS09670	COG1561	YicC-like family, N-terminal region
E1742_RS09680	COG0194	GDP metabolic process
E1742_RS09685	COG1758	RNA polymerase activity
E1742_RS09690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E1742_RS09720	COG3385	transposase activity
E1742_RS09740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E1742_RS09740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E1742_RS09760	COG2257	FlhB HrpN YscU SpaS Family
E1742_RS09765	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E1742_RS09770	COG1677	Flagellar hook-basal body complex protein FliE
E1742_RS09780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1742_RS09790	COG1157	protein secretion by the type III secretion system
E1742_RS09805	COG1580	Controls the rotational direction of flagella during chemotaxis
E1742_RS09810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1742_RS09815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1742_RS09825	COG1338	Plays a role in the flagellum-specific transport system
E1742_RS09830	COG1987	bacterial-type flagellum assembly
E1742_RS09835	COG1684	flagellar biosynthetic protein fliR
E1742_RS09875	COG1256	bacterial-type flagellum assembly
E1742_RS09880	COG3951	Flagellar rod assembly protein muramidase FlgJ
E1742_RS09880	COG1705	Flagellar rod assembly protein muramidase FlgJ
E1742_RS09885	COG1706	bacterial-type flagellum-dependent cell motility
E1742_RS09890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E1742_RS09900	COG4787	bacterial-type flagellum-dependent cell motility
E1742_RS09915	COG1558	bacterial-type flagellum-dependent cell motility
E1742_RS09920	COG1815	bacterial-type flagellum-dependent cell motility
E1742_RS09990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E1742_RS10015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E1742_RS10040	COG1187	pseudouridine synthase activity
E1742_RS10060	COG0546	phosphoglycolate phosphatase activity
E1742_RS10070	COG1530	ribonuclease E activity
E1742_RS10080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E1742_RS10105	COG5002	protein histidine kinase activity
E1742_RS10115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E1742_RS10120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E1742_RS10130	COG2766	serine protein kinase
E1742_RS10135	COG2718	Belongs to the UPF0229 family
E1742_RS10175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E1742_RS10180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E1742_RS10185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E1742_RS10190	COG0756	dUTP diphosphatase activity
E1742_RS10195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E1742_RS10205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E1742_RS10215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E1742_RS10220	COG0789	Transcriptional regulator
E1742_RS10235	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E1742_RS10240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E1742_RS10245	COG0167	dihydroorotate dehydrogenase activity
E1742_RS10250	COG0667	Aldo Keto reductase
E1742_RS10260	COG0583	DNA-binding transcription factor activity
E1742_RS10265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E1742_RS10270	COG4208	sulfate ABC transporter
E1742_RS10280	COG0450	alkyl hydroperoxide reductase
E1742_RS10290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E1742_RS10355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E1742_RS10360	COG1047	Peptidyl-prolyl cis-trans
E1742_RS10365	COG2003	Belongs to the UPF0758 family
E1742_RS10370	COG1368	sulfuric ester hydrolase activity
E1742_RS10375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E1742_RS10380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E1742_RS10390	COG3264	Mechanosensitive ion channel
E1742_RS10390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E1742_RS10395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E1742_RS10395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E1742_RS10400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E1742_RS10415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E1742_RS10420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E1742_RS10435	COG3209	COG3209 Rhs family protein
E1742_RS10480	COG0384	phenazine biosynthesis protein PhzF
E1742_RS10500	COG0840	transmembrane signaling receptor activity
E1742_RS10550	COG2723	6-phospho-beta-galactosidase activity
E1742_RS10575	COG4771	TonB-dependent receptor
E1742_RS10595	COG4977	sequence-specific DNA binding
E1742_RS10605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E1742_RS10610	COG0508	dehydrogenase complex catalyzes the overall conversion of
E1742_RS10615	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E1742_RS10620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E1742_RS10650	COG4654	Cytochrome c, class I
E1742_RS10670	COG0129	dihydroxy-acid dehydratase activity
E1742_RS10675	COG0583	DNA-binding transcription factor activity
E1742_RS10680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E1742_RS10685	COG2130	NADP-dependent
E1742_RS10700	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E1742_RS10710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E1742_RS10715	COG0459	protein refolding
E1742_RS10725	COG0028	Belongs to the TPP enzyme family
E1742_RS10745	COG2814	Major facilitator Superfamily
E1742_RS10755	COG0837	glucose binding
E1742_RS10755	COG1737	Transcriptional regulator
E1742_RS10760	COG0366	Alpha amylase catalytic
E1742_RS10780	COG0366	Alpha amylase catalytic
E1742_RS10785	COG0033	Phosphoglucomutase
E1742_RS10795	COG1501	Belongs to the glycosyl hydrolase 31 family
E1742_RS10805	COG4774	siderophore transport
E1742_RS10835	COG0402	S-adenosylhomocysteine deaminase activity
E1742_RS10850	COG1132	(ABC) transporter
E1742_RS10900	COG0583	DNA-binding transcription factor activity
E1742_RS10925	COG1846	Transcriptional regulator
E1742_RS10985	COG0840	transmembrane signaling receptor activity
E1742_RS11045	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E1742_RS11050	COG0308	aminopeptidase N
E1742_RS11065	COG1803	Methylglyoxal synthase
E1742_RS11070	COG0697	spore germination
E1742_RS11085	COG0217	transcriptional regulatory protein
E1742_RS11090	COG0151	Belongs to the GarS family
E1742_RS11095	COG0408	coproporphyrinogen oxidase activity
E1742_RS11105	COG0799	negative regulation of ribosome biogenesis
E1742_RS11110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E1742_RS11115	COG0424	maF-like protein
E1742_RS11120	COG1530	ribonuclease E activity
E1742_RS11150	COG1215	transferase activity, transferring glycosyl groups
E1742_RS11165	COG1054	Belongs to the UPF0176 family
E1742_RS11205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E1742_RS11205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E1742_RS11230	COG0438	transferase activity, transferring glycosyl groups
E1742_RS11235	COG0546	phosphoglycolate phosphatase activity
E1742_RS11235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E1742_RS11240	COG2076	Multidrug Resistance protein
E1742_RS11265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E1742_RS11265	COG2755	lipolytic protein G-D-S-L family
E1742_RS11280	COG0513	Belongs to the DEAD box helicase family
E1742_RS11285	COG2203	Gaf domain
E1742_RS11285	COG3706	GGDEF domain
E1742_RS11285	COG5001	Diguanylate cyclase
E1742_RS11285	COG4251	negative regulation of phosphorylation
E1742_RS11300	COG0840	transmembrane signaling receptor activity
E1742_RS11310	COG2080	2 iron, 2 sulfur cluster binding
E1742_RS11315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E1742_RS11320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E1742_RS11330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E1742_RS11365	COG3210	domain, Protein
E1742_RS11365	COG3210	domain, Protein
E1742_RS11370	COG2831	hemolysin activation secretion protein
E1742_RS11380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E1742_RS11385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E1742_RS11390	COG2080	2 iron, 2 sulfur cluster binding
E1742_RS11395	COG2832	Protein of unknown function (DUF454)
E1742_RS11410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E1742_RS11415	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS11425	COG1414	Transcriptional regulator
E1742_RS11430	COG0559	Belongs to the binding-protein-dependent transport system permease family
E1742_RS11455	COG1960	acyl-CoA dehydrogenase activity
E1742_RS11460	COG1960	acyl-CoA dehydrogenase activity
E1742_RS11470	COG1064	alcohol dehydrogenase
E1742_RS11490	COG3738	Protein conserved in bacteria
E1742_RS11495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E1742_RS11520	COG3842	ATPase activity
E1742_RS11525	COG3842	ATPase activity
E1742_RS11645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E1742_RS11660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E1742_RS11665	COG2081	HI0933 family
E1742_RS11670	COG2032	superoxide dismutase activity
E1742_RS11675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E1742_RS11685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E1742_RS11695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E1742_RS11720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E1742_RS11725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E1742_RS11755	COG4974	Belongs to the 'phage' integrase family
E1742_RS11785	COG4566	intracellular signal transduction
E1742_RS11795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E1742_RS11805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E1742_RS11810	COG0802	atpase or kinase
E1742_RS11815	COG0860	N-Acetylmuramoyl-L-alanine amidase
E1742_RS11825	COG3338	carbonate dehydratase activity
E1742_RS11830	COG0586	Pfam SNARE associated Golgi protein
E1742_RS11840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E1742_RS11845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E1742_RS11885	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E1742_RS11890	COG0477	Major facilitator Superfamily
E1742_RS11915	COG4206	TonB-dependent receptor
E1742_RS11920	COG2186	Transcriptional regulator
E1742_RS11930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E1742_RS11970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E1742_RS11975	COG1702	phosphate starvation-inducible protein PhoH
E1742_RS11980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E1742_RS11990	COG4535	Mg2 and Co2 transporter CorC
E1742_RS11995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E1742_RS12000	COG0752	glycyl-tRNA synthetase alpha subunit
E1742_RS12005	COG0751	glycine-tRNA ligase activity
E1742_RS12010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E1742_RS12060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E1742_RS12085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E1742_RS12100	COG0540	Belongs to the ATCase OTCase family
E1742_RS12105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E1742_RS12110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E1742_RS12115	COG1678	Uncharacterized ACR, COG1678
E1742_RS12120	COG0415	Belongs to the DNA photolyase family
E1742_RS12130	COG0643	Histidine kinase
E1742_RS12130	COG2198	Histidine kinase
E1742_RS12135	COG0840	transmembrane signaling receptor activity
E1742_RS12155	COG1773	rubredoxin
E1742_RS12165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E1742_RS12170	COG1914	H( )-stimulated, divalent metal cation uptake system
E1742_RS12175	COG0598	Magnesium transport protein CorA
E1742_RS12180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E1742_RS12200	COG0557	exoribonuclease II activity
E1742_RS12205	COG3161	chorismate lyase activity
E1742_RS12210	COG3150	esterase
E1742_RS12230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E1742_RS12235	COG0511	ligase activity, forming carbon-carbon bonds
E1742_RS12240	COG0439	Biotin carboxylase
E1742_RS12245	COG2264	protein methyltransferase activity
E1742_RS12255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1742_RS12260	COG0762	integral membrane protein
E1742_RS12280	COG0840	transmembrane signaling receptor activity
E1742_RS12370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E1742_RS12415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E1742_RS12440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E1742_RS12445	COG1116	anion transmembrane transporter activity
E1742_RS12450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E1742_RS12460	COG0501	Belongs to the peptidase M48B family
E1742_RS12465	COG4269	membrane
E1742_RS12475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E1742_RS12485	COG0741	lytic transglycosylase activity
E1742_RS12490	COG0442	prolyl-tRNA aminoacylation
E1742_RS12495	COG0494	nUDIX hydrolase
E1742_RS12515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E1742_RS12540	COG0745	RESPONSE REGULATOR receiver
E1742_RS12545	COG2205	protein histidine kinase activity
E1742_RS12550	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E1742_RS12555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E1742_RS12560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E1742_RS12615	COG0165	Argininosuccinate lyase
E1742_RS12625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E1742_RS12655	COG1012	belongs to the aldehyde dehydrogenase family
E1742_RS12655	COG2030	dehydratase
E1742_RS12665	COG0183	Belongs to the thiolase family
E1742_RS12675	COG2050	protein possibly involved in aromatic compounds catabolism
E1742_RS12680	COG1250	3-hydroxyacyl-CoA dehydrogenase
E1742_RS12690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E1742_RS12695	COG2151	metal-sulfur cluster biosynthetic enzyme
E1742_RS12700	COG3396	Phenylacetate-CoA oxygenase
E1742_RS12705	COG3460	Phenylacetate-CoA oxygenase
E1742_RS12710	COG3396	Phenylacetate-CoA oxygenase
E1742_RS12720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E1742_RS12725	COG2866	Carboxypeptidase
E1742_RS12755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E1742_RS12760	COG0312	modulator of DNA gyrase
E1742_RS12765	COG3028	Belongs to the UPF0307 family
E1742_RS12770	COG0521	Mo-molybdopterin cofactor biosynthetic process
E1742_RS12790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E1742_RS12800	COG2271	Major facilitator Superfamily
E1742_RS12805	COG1509	lysine 2,3-aminomutase activity
E1742_RS12815	COG0840	transmembrane signaling receptor activity
E1742_RS12820	COG2094	Belongs to the DNA glycosylase MPG family
E1742_RS12850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E1742_RS12855	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
E1742_RS12860	COG1335	isochorismatase
E1742_RS12905	COG1228	amidohydrolase
E1742_RS12925	COG2986	histidine ammonia-lyase
E1742_RS12930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E1742_RS12935	COG0583	DNA-binding transcription factor activity
E1742_RS12940	COG0667	Aldo Keto reductase
E1742_RS12945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E1742_RS12970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E1742_RS12970	COG2169	Transcriptional regulator
E1742_RS12985	COG2201	protein-glutamate methylesterase activity
E1742_RS12990	COG3118	belongs to the thioredoxin family
E1742_RS12995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E1742_RS13000	COG0254	rRNA binding
E1742_RS13035	COG0183	Belongs to the thiolase family
E1742_RS13040	COG0531	amino acid
E1742_RS13050	COG3685	Protein conserved in bacteria
E1742_RS13095	COG0738	Major facilitator superfamily
E1742_RS13100	COG1349	DNA-binding transcription factor activity
E1742_RS13110	COG2186	Transcriptional regulator
E1742_RS13115	COG3385	transposase activity
E1742_RS13120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E1742_RS13140	COG2271	Major facilitator Superfamily
E1742_RS13145	COG2205	protein histidine kinase activity
E1742_RS13145	COG0784	Response regulator, receiver
E1742_RS13150	COG3437	response regulator, receiver
E1742_RS13165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E1742_RS13170	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E1742_RS13205	COG2205	protein histidine kinase activity
E1742_RS13205	COG0784	Response regulator, receiver
E1742_RS13205	COG5002	protein histidine kinase activity
E1742_RS13210	COG1546	Belongs to the CinA family
E1742_RS13270	COG4771	TonB-dependent receptor
E1742_RS13280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E1742_RS13285	COG0259	pyridoxamine-phosphate oxidase activity
E1742_RS13295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E1742_RS13305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E1742_RS13310	COG1960	acyl-CoA dehydrogenase activity
E1742_RS13315	COG5002	protein histidine kinase activity
E1742_RS13320	COG3047	cAMP biosynthetic process
E1742_RS13330	COG0009	L-threonylcarbamoyladenylate synthase
E1742_RS13335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E1742_RS13340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E1742_RS13345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E1742_RS13355	COG0469	pyruvate kinase activity
E1742_RS13360	COG0126	phosphoglycerate kinase activity
E1742_RS13400	COG0315	cyclic pyranopterin monophosphate synthase activity
E1742_RS13415	COG4969	Belongs to the N-Me-Phe pilin family
E1742_RS13425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E1742_RS13430	COG0045	succinate-CoA ligase (ADP-forming) activity
E1742_RS13460	COG2267	carboxylic ester hydrolase activity
E1742_RS13465	COG4221	oxidoreductase activity
E1742_RS13470	COG1902	pentaerythritol trinitrate reductase activity
E1742_RS13485	COG2137	regulation of response to DNA damage stimulus
E1742_RS13490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E1742_RS13500	COG0642	Histidine kinase
E1742_RS13510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E1742_RS13525	COG0205	6-phosphofructokinase activity
E1742_RS13540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E1742_RS13555	COG0617	tRNA 3'-terminal CCA addition
E1742_RS13560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E1742_RS13575	COG4670	ketone body catabolic process
E1742_RS13585	COG1309	transcriptional regulator
E1742_RS13595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E1742_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
E1742_RS13615	COG0673	inositol 2-dehydrogenase activity
E1742_RS13630	COG0174	glutamine synthetase
E1742_RS13635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E1742_RS13650	COG0745	RESPONSE REGULATOR receiver
E1742_RS13670	COG1175	transmembrane transport
E1742_RS13675	COG0395	ABC-type sugar transport system, permease component
E1742_RS13690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E1742_RS13695	COG2146	nitrite reductase [NAD(P)H] activity
E1742_RS13700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E1742_RS13710	COG1116	anion transmembrane transporter activity
E1742_RS13710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E1742_RS13735	COG2175	clavaminate synthase activity
E1742_RS13740	COG3647	Membrane
E1742_RS13745	COG1573	uracil-dna glycosylase
E1742_RS13755	COG0288	reversible hydration of carbon dioxide
E1742_RS13760	COG0484	heat shock protein binding
E1742_RS13765	COG0443	Heat shock 70 kDa protein
E1742_RS13770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E1742_RS13775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E1742_RS13785	COG0497	DNA recombination
E1742_RS13830	COG0346	lactoylglutathione lyase activity
E1742_RS13845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E1742_RS13855	COG2733	membrane
E1742_RS13870	COG0596	Alpha beta hydrolase
E1742_RS13875	COG1609	Transcriptional regulator
E1742_RS13885	COG1968	undecaprenyl-diphosphatase activity
E1742_RS13890	COG0514	ATP-dependent DNA helicase (RecQ)
E1742_RS13900	COG0697	spore germination
E1742_RS13905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E1742_RS13910	COG5002	protein histidine kinase activity
E1742_RS13935	COG4206	TonB-dependent receptor
E1742_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS13990	COG1136	(ABC) transporter
E1742_RS13990	COG0577	efflux transmembrane transporter activity
E1742_RS14035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E1742_RS14045	COG1136	(ABC) transporter
E1742_RS14045	COG0577	efflux transmembrane transporter activity
E1742_RS14060	COG3852	Histidine kinase
E1742_RS14065	COG2814	Major facilitator Superfamily
E1742_RS14080	COG1981	membrane
E1742_RS14085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E1742_RS14100	COG0495	leucyl-tRNA aminoacylation
E1742_RS14145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E1742_RS14150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E1742_RS14155	COG0735	belongs to the Fur family
E1742_RS14160	COG1420	regulation of RNA biosynthetic process
E1742_RS14185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E1742_RS14190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E1742_RS14195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E1742_RS14200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E1742_RS14205	COG3178	'Phosphotransferase
E1742_RS14210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E1742_RS14215	COG0006	proline dipeptidase activity
E1742_RS14220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E1742_RS14225	COG0432	Pfam Uncharacterised protein family UPF0047
E1742_RS14235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1742_RS14245	COG1472	Belongs to the glycosyl hydrolase 3 family
E1742_RS14285	COG0482	sulfurtransferase activity
E1742_RS14295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E1742_RS14305	COG4774	siderophore transport
E1742_RS14345	COG3128	pkhd-type hydroxylase
E1742_RS14370	COG3038	cytochrome b561
E1742_RS14375	COG2353	YceI-like domain
E1742_RS14395	COG5002	protein histidine kinase activity
E1742_RS14425	COG0583	DNA-binding transcription factor activity
E1742_RS14435	COG0431	NADPH-dependent FMN reductase
E1742_RS14440	COG0386	Belongs to the glutathione peroxidase family
E1742_RS14450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E1742_RS14470	COG1289	transmembrane transporter activity
E1742_RS14475	COG0697	spore germination
E1742_RS14485	COG0727	PFAM Uncharacterised protein family (UPF0153)
E1742_RS14495	COG0823	Involved in the tonB-independent uptake of proteins
E1742_RS14500	COG0531	amino acid
E1742_RS14510	COG1902	pentaerythritol trinitrate reductase activity
E1742_RS14525	COG2902	Dehydrogenase
E1742_RS14550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E1742_RS14590	COG0625	glutathione transferase activity
E1742_RS14605	COG1609	Transcriptional regulator
E1742_RS14610	COG3265	gluconokinase activity
E1742_RS14615	COG3459	Glycosyltransferase 36 associated
E1742_RS14620	COG2211	Major facilitator Superfamily
E1742_RS14625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E1742_RS14630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E1742_RS14635	COG1862	Preprotein translocase
E1742_RS14640	COG0343	queuine tRNA-ribosyltransferase activity
E1742_RS14645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E1742_RS14660	COG0739	heme binding
E1742_RS14685	COG0673	inositol 2-dehydrogenase activity
E1742_RS14695	COG0418	dihydroorotase activity
E1742_RS14700	COG1126	abc transporter atp-binding protein
E1742_RS14705	COG1301	dicarboxylic acid transport
E1742_RS14715	COG5265	(ABC) transporter
E1742_RS14725	COG3540	Alkaline phosphatase
E1742_RS14735	COG1960	acyl-CoA dehydrogenase activity
E1742_RS14750	COG0583	DNA-binding transcription factor activity
E1742_RS14755	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS14760	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS14770	COG0243	molybdopterin cofactor binding
E1742_RS14775	COG1473	amidohydrolase
E1742_RS14785	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E1742_RS14820	COG4676	Protein conserved in bacteria
E1742_RS14825	COG4676	Protein conserved in bacteria
E1742_RS14830	COG5445	Predicted secreted protein (DUF2300)
E1742_RS14835	COG2373	Large extracellular alpha-helical protein
E1742_RS14845	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E1742_RS14900	COG2366	antibiotic biosynthetic process
E1742_RS14945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E1742_RS14950	COG1127	ABC transporter
E1742_RS14970	COG3411	Ferredoxin
E1742_RS14975	COG2945	thiolester hydrolase activity
E1742_RS14980	COG1686	Belongs to the peptidase S11 family
E1742_RS15040	COG0438	transferase activity, transferring glycosyl groups
E1742_RS15045	COG0367	asparagine synthase
E1742_RS15050	COG0438	transferase activity, transferring glycosyl groups
E1742_RS15080	COG3409	Peptidoglycan-binding domain 1 protein
E1742_RS15080	COG3267	Type II secretory pathway component ExeA
E1742_RS15090	COG0489	protein tyrosine kinase activity
E1742_RS15130	COG1196	nuclear chromosome segregation
E1742_RS15130	COG0741	lytic transglycosylase activity
E1742_RS15130	COG0739	heme binding
E1742_RS15155	COG0367	asparagine synthase
E1742_RS15175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E1742_RS15205	COG2204	response regulator
E1742_RS15215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E1742_RS15220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E1742_RS15230	COG0438	transferase activity, transferring glycosyl groups
E1742_RS15240	COG1215	transferase activity, transferring glycosyl groups
E1742_RS15255	COG0438	transferase activity, transferring glycosyl groups
E1742_RS15295	COG3052	prosthetic group binding
E1742_RS15330	COG3590	peptidase
E1742_RS15335	COG3590	peptidase
E1742_RS15340	COG4771	TonB-dependent receptor
E1742_RS15350	COG0793	Belongs to the peptidase S41A family
E1742_RS15360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E1742_RS15360	COG4651	solute:proton antiporter activity
E1742_RS15365	COG1902	pentaerythritol trinitrate reductase activity
E1742_RS15365	COG0446	pyridine nucleotide-disulphide oxidoreductase
E1742_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS15400	COG0183	Belongs to the thiolase family
E1742_RS15410	COG0583	DNA-binding transcription factor activity
E1742_RS15415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E1742_RS15420	COG0850	regulation of cytokinetic process
E1742_RS15430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E1742_RS15440	COG0745	RESPONSE REGULATOR receiver
E1742_RS15445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E1742_RS15450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E1742_RS15455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E1742_RS15460	COG2890	protein-(glutamine-N5) methyltransferase activity
E1742_RS15465	COG2918	glutathione biosynthetic process
E1742_RS15490	COG1764	response to oxidative stress
E1742_RS15510	COG3158	transport of potassium into the cell
E1742_RS15520	COG2962	Rard protein
E1742_RS15525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E1742_RS15525	COG2755	lipolytic protein G-D-S-L family
E1742_RS15530	COG0488	(ABC) transporter
E1742_RS15535	COG3385	transposase activity
E1742_RS15600	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E1742_RS15615	COG2070	2-Nitropropane dioxygenase
E1742_RS15645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E1742_RS15665	COG1309	transcriptional regulator
E1742_RS15680	COG5507	3-demethylubiquinone-9 3-methyltransferase
E1742_RS15710	COG2326	polyphosphate kinase activity
E1742_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS15745	COG0800	Aldolase
E1742_RS15750	COG3734	2-keto-3-deoxy-galactonokinase
E1742_RS15760	COG0745	RESPONSE REGULATOR receiver
E1742_RS15765	COG2972	Histidine kinase
E1742_RS15775	COG3338	carbonate dehydratase activity
E1742_RS15785	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E1742_RS15805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E1742_RS15810	COG1162	GTPase activity
E1742_RS15825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E1742_RS15830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E1742_RS15835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E1742_RS15840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E1742_RS15845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E1742_RS15850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E1742_RS15860	COG0356	it plays a direct role in the translocation of protons across the membrane
E1742_RS15870	COG1475	DNA binding
E1742_RS15875	COG1192	Involved in chromosome partitioning
E1742_RS15880	COG0357	Ribosomal RNA small subunit methyltransferase G
E1742_RS15885	COG0445	tRNA wobble uridine modification
E1742_RS15925	COG0411	ABC transporter
E1742_RS15940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E1742_RS15945	COG0506	proline dehydrogenase activity
E1742_RS15945	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E1742_RS15945	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E1742_RS15955	COG0840	transmembrane signaling receptor activity
E1742_RS15975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E1742_RS15980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E1742_RS15985	COG0742	ribosomal rna small subunit methyltransferase
E1742_RS15995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E1742_RS16005	COG1522	sequence-specific DNA binding
E1742_RS16030	COG1538	Outer membrane efflux protein
E1742_RS16045	COG2814	Major facilitator Superfamily
E1742_RS16095	COG0840	transmembrane signaling receptor activity
E1742_RS16110	COG0454	-acetyltransferase
E1742_RS16135	COG5002	protein histidine kinase activity
E1742_RS16135	COG5001	Diguanylate cyclase
E1742_RS16155	COG5001	Diguanylate cyclase
E1742_RS16160	COG0840	transmembrane signaling receptor activity
E1742_RS16195	COG4585	Histidine kinase
E1742_RS16200	COG2197	response regulator
E1742_RS16225	COG4964	Belongs to the GSP D family
E1742_RS16300	COG2353	YceI-like domain
E1742_RS16305	COG0697	spore germination
E1742_RS16310	COG0583	DNA-binding transcription factor activity
E1742_RS16320	COG0583	DNA-binding transcription factor activity
E1742_RS16330	COG1090	epimerase
E1742_RS16345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E1742_RS16355	COG0348	domain, Protein
E1742_RS16375	COG3278	Belongs to the heme-copper respiratory oxidase family
E1742_RS16385	COG2217	Heavy metal translocating P-type atpase
E1742_RS16395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E1742_RS16400	COG0840	transmembrane signaling receptor activity
E1742_RS16405	COG4682	membrane
E1742_RS16410	COG2354	Protein conserved in bacteria
E1742_RS16415	COG1280	lysine exporter protein (LysE YggA)
E1742_RS16425	COG2921	Belongs to the UPF0250 family
E1742_RS16430	COG0321	lipoyl(octanoyl) transferase activity
E1742_RS16435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E1742_RS16450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E1742_RS16455	COG0590	tRNA wobble adenosine to inosine editing
E1742_RS16455	COG0037	tRNA processing
E1742_RS16470	COG2186	Transcriptional regulator
E1742_RS16475	COG3845	ABC transporter
E1742_RS16480	COG4603	Belongs to the binding-protein-dependent transport system permease family
E1742_RS16485	COG1079	Belongs to the binding-protein-dependent transport system permease family
E1742_RS16495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E1742_RS16500	COG2823	Periplasmic or secreted lipoprotein
E1742_RS16505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E1742_RS16510	COG0792	nuclease activity
E1742_RS16525	COG0625	glutathione transferase activity
E1742_RS16545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E1742_RS16550	COG4770	biotin carboxylase activity
E1742_RS16555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E1742_RS16560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E1742_RS16565	COG0156	8-amino-7-oxononanoate synthase activity
E1742_RS16575	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E1742_RS16580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E1742_RS16585	COG3012	SEC-C Motif Domain Protein
E1742_RS16590	COG5002	protein histidine kinase activity
E1742_RS16610	COG2188	Transcriptional regulator
E1742_RS16615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E1742_RS16620	COG2807	transmembrane transport
E1742_RS16625	COG1649	PFAM Uncharacterised BCR, COG1649
E1742_RS16635	COG3023	N-Acetylmuramoyl-L-alanine amidase
E1742_RS16655	COG0700	Nucleoside recognition
E1742_RS16665	COG4206	TonB-dependent receptor
E1742_RS16670	COG1619	proteins homologs of microcin C7 resistance protein MccF
E1742_RS16675	COG5002	protein histidine kinase activity
E1742_RS16680	COG1295	ribonuclease BN
E1742_RS16685	COG2205	protein histidine kinase activity
E1742_RS16695	COG0745	RESPONSE REGULATOR receiver
E1742_RS16700	COG1960	acyl-CoA dehydrogenase activity
E1742_RS16705	COG0300	oxidoreductase activity
E1742_RS16720	COG1960	acyl-CoA dehydrogenase activity
E1742_RS16725	COG0789	Transcriptional regulator
E1742_RS16730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1742_RS16745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E1742_RS16750	COG2183	response to ionizing radiation
E1742_RS16755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E1742_RS16760	COG2205	protein histidine kinase activity
E1742_RS16765	COG0745	RESPONSE REGULATOR receiver
E1742_RS16780	COG0067	glutamate synthase
E1742_RS16780	COG0069	glutamate synthase activity
E1742_RS16780	COG0070	glutamate synthase
E1742_RS16790	COG1127	ABC transporter
E1742_RS16795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E1742_RS16800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E1742_RS16820	COG1131	(ABC) transporter
E1742_RS16825	COG0842	Transport permease protein
E1742_RS16830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E1742_RS16835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E1742_RS16840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E1742_RS16850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E1742_RS16865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E1742_RS16870	COG0107	imidazoleglycerol-phosphate synthase activity
E1742_RS16875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E1742_RS16880	COG0140	phosphoribosyl-ATP diphosphatase activity
E1742_RS16890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E1742_RS16895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E1742_RS16900	COG0805	protein transport
E1742_RS16905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E1742_RS16910	COG1309	transcriptional regulator
E1742_RS16945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E1742_RS16950	COG1073	alpha beta
E1742_RS16955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E1742_RS16960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E1742_RS16975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E1742_RS16990	COG0210	DNA helicase
E1742_RS16995	COG2900	Belongs to the SlyX family
E1742_RS17025	COG0339	signal peptide processing
E1742_RS17030	COG0339	signal peptide processing
E1742_RS17040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E1742_RS17045	COG0789	Transcriptional regulator
E1742_RS17055	COG1032	radical SAM domain protein
E1742_RS17105	COG0450	alkyl hydroperoxide reductase
E1742_RS17110	COG3634	alkyl hydroperoxide reductase activity
E1742_RS17120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E1742_RS17140	COG2271	Major facilitator Superfamily
E1742_RS17155	COG0840	transmembrane signaling receptor activity
E1742_RS17165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E1742_RS17175	COG0500	methyltransferase
E1742_RS17195	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E1742_RS17240	COG0629	single-stranded DNA binding
E1742_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS17265	COG2207	Transcriptional regulator
E1742_RS17270	COG0655	NAD(P)H dehydrogenase (quinone) activity
E1742_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS17300	COG4221	oxidoreductase activity
E1742_RS17305	COG2207	Transcriptional regulator
E1742_RS17370	COG2816	NAD+ diphosphatase activity
E1742_RS17375	COG0302	gtp cyclohydrolase
E1742_RS17385	COG2198	Histidine kinase
E1742_RS17385	COG0784	Response regulator, receiver
E1742_RS17385	COG5002	protein histidine kinase activity
E1742_RS17390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E1742_RS17420	COG3047	cAMP biosynthetic process
E1742_RS17450	COG3258	Cytochrome c
E1742_RS17460	COG0446	pyridine nucleotide-disulphide oxidoreductase
E1742_RS17510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E1742_RS17515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E1742_RS17520	COG0594	ribonuclease P activity
E1742_RS17525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E1742_RS17530	COG0706	membrane insertase activity
E1742_RS17555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E1742_RS17580	COG1183	phosphatidylcholine synthase activity
E1742_RS17585	COG4989	oxidoreductase activity
E1742_RS17595	COG1609	Transcriptional regulator
E1742_RS17605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E1742_RS17670	COG4964	Belongs to the GSP D family
E1742_RS17725	COG0473	3-isopropylmalate dehydrogenase activity
E1742_RS17730	COG0583	DNA-binding transcription factor activity
E1742_RS17745	COG1970	mechanosensitive ion channel activity
E1742_RS17750	COG0723	plastoquinol--plastocyanin reductase activity
E1742_RS17755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E1742_RS17760	COG2857	Cytochrome c1
E1742_RS17765	COG0625	glutathione transferase activity
E1742_RS17770	COG2969	positive regulation of protein catabolic process
E1742_RS17780	COG1253	flavin adenine dinucleotide binding
E1742_RS17830	COG0596	Alpha beta hydrolase
E1742_RS17835	COG2205	protein histidine kinase activity
E1742_RS17855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E1742_RS17865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E1742_RS17875	COG4942	peptidase
E1742_RS17880	COG0793	Belongs to the peptidase S41A family
E1742_RS17885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E1742_RS17955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E1742_RS17960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E1742_RS17975	COG0523	cobalamin synthesis protein
E1742_RS17980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E1742_RS18000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E1742_RS18015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E1742_RS18020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E1742_RS18025	COG1950	PFAM Membrane protein of
E1742_RS18035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E1742_RS18050	COG0617	tRNA 3'-terminal CCA addition
E1742_RS18070	COG1522	sequence-specific DNA binding
E1742_RS18085	COG4771	TonB-dependent receptor
E1742_RS18095	COG0037	tRNA processing
E1742_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS18115	COG0484	heat shock protein binding
E1742_RS18125	COG0784	Response regulator, receiver
E1742_RS18125	COG3437	response regulator, receiver
E1742_RS18150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E1742_RS18160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E1742_RS18170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E1742_RS18175	COG0081	regulation of translation
E1742_RS18180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E1742_RS18185	COG0222	ribosome binding
E1742_RS18190	COG0085	RNA polymerase activity
E1742_RS18195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E1742_RS18220	COG2205	protein histidine kinase activity
E1742_RS18220	COG0784	Response regulator, receiver
E1742_RS18245	COG1522	sequence-specific DNA binding
E1742_RS18260	COG2119	membrane
E1742_RS18305	COG0714	Associated with various cellular activities
E1742_RS18360	COG5002	protein histidine kinase activity
E1742_RS18370	COG0577	efflux transmembrane transporter activity
E1742_RS18375	COG1136	(ABC) transporter
E1742_RS18375	COG0577	efflux transmembrane transporter activity
E1742_RS18380	COG1136	(ABC) transporter
E1742_RS18395	COG2194	sulfuric ester hydrolase activity
E1742_RS18400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E1742_RS18405	COG0049	tRNA binding
E1742_RS18410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E1742_RS18415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E1742_RS18420	COG0051	transcription antitermination factor activity, RNA binding
E1742_RS18425	COG4206	TonB-dependent receptor
E1742_RS18450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E1742_RS18455	COG0088	Forms part of the polypeptide exit tunnel
E1742_RS18460	COG0089	rRNA binding
E1742_RS18465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E1742_RS18470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E1742_RS18475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E1742_RS18480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E1742_RS18485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E1742_RS18490	COG0255	Belongs to the universal ribosomal protein uL29 family
E1742_RS18495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E1742_RS18500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E1742_RS18505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E1742_RS18510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E1742_RS18515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E1742_RS18520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E1742_RS18525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E1742_RS18530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E1742_RS18535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E1742_RS18540	COG1841	ribosomal large subunit assembly
E1742_RS18545	COG0200	Binds to the 23S rRNA
E1742_RS18550	COG0201	protein transport
E1742_RS18555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E1742_RS18560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E1742_RS18565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E1742_RS18570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E1742_RS18575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E1742_RS18580	COG0202	RNA polymerase activity
E1742_RS18585	COG0203	ribosomal protein L17
E1742_RS18590	COG4232	protein-disulfide reductase activity
E1742_RS18630	COG2814	Major facilitator Superfamily
E1742_RS18645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E1742_RS18655	COG1333	cytochrome c biogenesis protein
E1742_RS18660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E1742_RS18665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E1742_RS18670	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E1742_RS18685	COG1965	Belongs to the frataxin family
E1742_RS18690	COG0659	secondary active sulfate transmembrane transporter activity
E1742_RS18730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E1742_RS18740	COG1194	a g-specific adenine glycosylase
E1742_RS18750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E1742_RS18760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E1742_RS18765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E1742_RS18775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E1742_RS18780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E1742_RS18795	COG0193	aminoacyl-tRNA hydrolase activity
E1742_RS18800	COG0012	GTP binding
E1742_RS18825	COG3217	Mosc domain protein beta barrel domain protein
E1742_RS18825	COG0633	Ferredoxin
E1742_RS18910	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E1742_RS18925	COG1137	ATPase activity
E1742_RS18930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E1742_RS18935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E1742_RS18950	COG1660	Displays ATPase and GTPase activities
E1742_RS18960	COG3263	regulation of cellular component size
E1742_RS18970	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E1742_RS18980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E1742_RS18980	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E1742_RS18985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E1742_RS18990	COG1238	metal cluster binding
E1742_RS19010	COG0840	transmembrane signaling receptor activity
E1742_RS19025	COG2226	methyltransferase
E1742_RS19040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E1742_RS19045	COG0500	methyltransferase
E1742_RS19060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E1742_RS19065	COG0494	nUDIX hydrolase
E1742_RS19070	COG3568	Endonuclease Exonuclease Phosphatase
E1742_RS19075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E1742_RS19090	COG1960	acyl-CoA dehydrogenase activity
E1742_RS19095	COG1250	3-hydroxyacyl-CoA dehydrogenase
E1742_RS19095	COG1024	Enoyl-CoA hydratase
E1742_RS19100	COG0183	Belongs to the thiolase family
E1742_RS19105	COG1024	Enoyl-CoA hydratase
E1742_RS19135	COG1404	Belongs to the peptidase S8 family
E1742_RS19185	COG2818	Glycosylase
E1742_RS19190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E1742_RS19190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E1742_RS19195	COG2205	protein histidine kinase activity
E1742_RS19245	COG1090	epimerase
E1742_RS19275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E1742_RS19295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E1742_RS19295	COG4191	Histidine kinase
E1742_RS19300	COG0784	Response regulator, receiver
E1742_RS19300	COG3437	response regulator, receiver
E1742_RS19330	COG0412	Dienelactone hydrolase
E1742_RS19425	COG0300	oxidoreductase activity
E1742_RS19450	COG0840	transmembrane signaling receptor activity
E1742_RS19465	COG0784	Response regulator, receiver
E1742_RS19465	COG4191	Histidine kinase
E1742_RS19485	COG0668	transmembrane transport
E1742_RS19525	COG3122	Protein conserved in bacteria
E1742_RS19540	COG0861	Integral membrane protein TerC family
E1742_RS19555	COG0583	DNA-binding transcription factor activity
E1742_RS19580	COG0583	DNA-binding transcription factor activity
E1742_RS19585	COG1942	4-Oxalocrotonate Tautomerase
E1742_RS19595	COG4294	response to UV
E1742_RS19620	COG0579	oxidoreductase
E1742_RS19640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E1742_RS19645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E1742_RS19675	COG0134	indole-3-glycerol-phosphate synthase activity
E1742_RS19685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E1742_RS19690	COG0512	Glutamine amidotransferase of anthranilate synthase
E1742_RS19700	COG0546	phosphoglycolate phosphatase activity
E1742_RS19705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E1742_RS19710	COG2967	ApaG domain
E1742_RS19715	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E1742_RS19760	COG0477	Major facilitator Superfamily
E1742_RS19765	COG1492	cobalamin metabolic process
E1742_RS19770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E1742_RS19790	COG1797	cobyrinic acid a,c-diamide synthase activity
E1742_RS19800	COG1120	ATPase activity
E1742_RS19805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E1742_RS19810	COG4206	TonB-dependent receptor
E1742_RS19820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E1742_RS19825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E1742_RS19830	COG0745	RESPONSE REGULATOR receiver
E1742_RS19835	COG2205	protein histidine kinase activity
E1742_RS19840	COG2194	sulfuric ester hydrolase activity
E1742_RS19880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E1742_RS19895	COG3437	response regulator, receiver
E1742_RS19905	COG1690	Belongs to the RtcB family
E1742_RS19910	COG0430	RNA-3'-phosphate cyclase activity
E1742_RS19915	COG4772	TonB-dependent receptor
E1742_RS19955	COG0606	chelatase, subunit chli
E1742_RS19970	COG0347	Belongs to the P(II) protein family
E1742_RS19975	COG0004	ammonium transporteR
E1742_RS19985	COG0189	ligase activity
E1742_RS20000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E1742_RS20005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E1742_RS20010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E1742_RS20010	COG2813	Specifically methylates the guanine in position
E1742_RS20025	COG0708	Exodeoxyribonuclease III
E1742_RS20030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E1742_RS20050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E1742_RS20060	COG2267	carboxylic ester hydrolase activity
E1742_RS20075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E1742_RS20080	COG0154	amidase activity
E1742_RS20085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E1742_RS20090	COG1077	Cell shape determining protein MreB Mrl
E1742_RS20105	COG0768	penicillin binding
E1742_RS20110	COG0772	Belongs to the SEDS family
E1742_RS20125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E1742_RS20135	COG0300	oxidoreductase activity
E1742_RS20140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E1742_RS20150	COG0018	arginyl-trna synthetase
E1742_RS20165	COG5000	phosphorelay sensor kinase activity
E1742_RS20170	COG2204	response regulator
E1742_RS20170	COG2204	response regulator
E1742_RS20185	COG0121	glutamine amidotransferase
E1742_RS20190	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E1742_RS20205	COG0583	DNA-binding transcription factor activity
E1742_RS20220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E1742_RS20225	COG0242	peptide deformylase activity
E1742_RS20235	COG0758	DNA mediated transformation
E1742_RS20240	COG2922	Belongs to the Smg family
E1742_RS20255	COG0840	transmembrane signaling receptor activity
E1742_RS20275	COG1131	(ABC) transporter
E1742_RS20285	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E1742_RS20290	COG2321	neutral zinc metallopeptidase
E1742_RS20300	COG1765	OsmC-like protein
E1742_RS20310	COG4555	ABC transporter
E1742_RS20320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E1742_RS20325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E1742_RS20330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E1742_RS20335	COG0316	Belongs to the HesB IscA family
E1742_RS20350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E1742_RS20355	COG1196	nuclear chromosome segregation
E1742_RS20355	COG0741	lytic transglycosylase activity
E1742_RS20355	COG0739	heme binding
E1742_RS20360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E1742_RS20380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E1742_RS20385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E1742_RS20390	COG0138	bifunctional purine biosynthesis protein purh
E1742_RS20395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E1742_RS20400	COG0632	four-way junction helicase activity
E1742_RS20405	COG2255	four-way junction helicase activity
E1742_RS20410	COG1671	Belongs to the UPF0178 family
E1742_RS20425	COG0280	phosphate acetyltransferase
E1742_RS20425	COG0281	malic enzyme
E1742_RS20435	COG0525	valine-tRNA ligase activity
E1742_RS20450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E1742_RS20460	COG2022	thiamine diphosphate biosynthetic process
E1742_RS20465	COG0351	phosphomethylpyrimidine kinase
E1742_RS20470	COG0352	thiamine-phosphate diphosphorylase activity
E1742_RS20475	COG0745	RESPONSE REGULATOR receiver
E1742_RS20495	COG0210	DNA helicase
E1742_RS20505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E1742_RS20520	COG0412	Dienelactone hydrolase
E1742_RS20555	COG1722	exodeoxyribonuclease VII activity
E1742_RS20560	COG0142	geranyltranstransferase activity
E1742_RS20565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E1742_RS20585	COG3275	phosphorelay sensor kinase activity
E1742_RS20595	COG2096	Adenosyltransferase
E1742_RS20600	COG0277	FAD linked oxidase domain protein
E1742_RS20610	COG0247	lactate metabolic process
E1742_RS20620	COG0386	Belongs to the glutathione peroxidase family
E1742_RS20655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E1742_RS20660	COG0583	DNA-binding transcription factor activity
E1742_RS20665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E1742_RS20690	COG1040	competence protein
E1742_RS20695	COG2226	methyltransferase
E1742_RS20705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E1742_RS20710	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E1742_RS20745	COG0109	protoheme IX farnesyltransferase activity
E1742_RS20750	COG1999	signal sequence binding
E1742_RS20765	COG0628	permease
E1742_RS20775	COG1253	flavin adenine dinucleotide binding
E1742_RS20780	COG0583	DNA-binding transcription factor activity
E1742_RS20835	COG1131	(ABC) transporter
E1742_RS20840	COG0681	Belongs to the peptidase S26 family
E1742_RS20860	COG4773	Receptor
E1742_RS20870	COG0405	Gamma-glutamyltransferase
E1742_RS20880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E1742_RS20885	COG2177	Part of the ABC transporter FtsEX involved in
E1742_RS20890	COG2884	Cell division ATP-binding protein ftsE
E1742_RS20915	COG0840	transmembrane signaling receptor activity
E1742_RS20980	COG2001	Belongs to the MraZ family
E1742_RS20985	COG0275	rRNA processing
E1742_RS20990	COG3116	cell division
E1742_RS21000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E1742_RS21005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E1742_RS21010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E1742_RS21015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E1742_RS21030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E1742_RS21035	COG1181	Belongs to the D-alanine--D-alanine ligase family
E1742_RS21040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E1742_RS21050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E1742_RS21055	COG0678	peroxiredoxin activity
E1742_RS21075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E1742_RS21085	COG0653	protein targeting
E1742_RS21090	COG0840	transmembrane signaling receptor activity
E1742_RS21130	COG0494	nUDIX hydrolase
E1742_RS21135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E1742_RS21150	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS21180	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E1742_RS21185	COG0534	Mate efflux family protein
E1742_RS21190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E1742_RS21205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E1742_RS21205	COG0318	PFAM AMP-dependent synthetase and ligase
E1742_RS21205	COG3321	synthase
E1742_RS21205	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS21205	COG0300	oxidoreductase activity
E1742_RS21220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E1742_RS21235	COG2197	response regulator
E1742_RS21240	COG2977	Belongs to the P-Pant transferase superfamily
E1742_RS21245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E1742_RS21250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E1742_RS21255	COG0237	dephospho-CoA kinase activity
E1742_RS21260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E1742_RS21275	COG4536	flavin adenine dinucleotide binding
E1742_RS21285	COG2351	hydroxyisourate hydrolase activity
E1742_RS21290	COG2272	Belongs to the type-B carboxylesterase lipase family
E1742_RS21320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E1742_RS21330	COG0402	S-adenosylhomocysteine deaminase activity
E1742_RS21350	COG0737	Belongs to the 5'-nucleotidase family
E1742_RS21370	COG0494	nUDIX hydrolase
E1742_RS21380	COG1079	Belongs to the binding-protein-dependent transport system permease family
E1742_RS21385	COG4603	Belongs to the binding-protein-dependent transport system permease family
E1742_RS21390	COG3845	ABC transporter
E1742_RS21395	COG1744	ABC transporter substrate-binding protein PnrA-like
E1742_RS21400	COG4771	TonB-dependent receptor
E1742_RS21415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E1742_RS21420	COG0583	DNA-binding transcription factor activity
E1742_RS21425	COG2313	pseudouridylate synthase activity
E1742_RS21430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1742_RS21430	COG1522	sequence-specific DNA binding
E1742_RS21435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E1742_RS21440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E1742_RS21445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E1742_RS21450	COG1012	belongs to the aldehyde dehydrogenase family
E1742_RS21475	COG3279	Response regulator of the LytR AlgR family
E1742_RS21495	COG1309	transcriptional regulator
E1742_RS21500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E1742_RS21505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E1742_RS21510	COG0686	Belongs to the AlaDH PNT family
E1742_RS21520	COG0493	'glutamate synthase
E1742_RS21530	COG1953	Uracil, thiamine, allantoin
E1742_RS21565	COG0583	DNA-binding transcription factor activity
E1742_RS21575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E1742_RS21580	COG4946	Tricorn protease homolog
E1742_RS21580	COG0823	Involved in the tonB-independent uptake of proteins
E1742_RS21580	COG1506	peptidase
E1742_RS21590	COG2205	protein histidine kinase activity
E1742_RS21590	COG0784	Response regulator, receiver
E1742_RS21590	COG2198	Histidine kinase
E1742_RS21600	COG2172	sigma factor antagonist activity
E1742_RS21605	COG1366	Belongs to the anti-sigma-factor antagonist family
E1742_RS21610	COG1366	Belongs to the anti-sigma-factor antagonist family
E1742_RS21645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E1742_RS21650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E1742_RS21660	COG3275	phosphorelay sensor kinase activity
E1742_RS21665	COG3279	Response regulator of the LytR AlgR family
E1742_RS21670	COG0484	heat shock protein binding
E1742_RS21695	COG0640	Transcriptional regulator
E1742_RS21700	COG1393	Belongs to the ArsC family
E1742_RS21710	COG4677	pectinesterase activity
E1742_RS21725	COG2186	Transcriptional regulator
E1742_RS21730	COG0142	geranyltranstransferase activity
E1742_RS21735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E1742_RS21740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E1742_RS21745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E1742_RS21750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E1742_RS21755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E1742_RS21760	COG2878	Part of a membrane complex involved in electron transport
E1742_RS21780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E1742_RS21800	COG0776	regulation of translation
E1742_RS21865	COG0174	glutamine synthetase
E1742_RS21885	COG0598	Magnesium transport protein CorA
E1742_RS21890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E1742_RS21895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E1742_RS21905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E1742_RS21920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E1742_RS21925	COG3164	Protein of unknown function
E1742_RS21930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E1742_RS21935	COG0312	modulator of DNA gyrase
E1742_RS21940	COG4771	TonB-dependent receptor
E1742_RS21950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E1742_RS21970	COG4206	TonB-dependent receptor
E1742_RS21975	COG4206	TonB-dependent receptor
E1742_RS21980	COG0601	transmembrane transport
E1742_RS21985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E1742_RS21990	COG4172	Belongs to the ABC transporter superfamily
E1742_RS22000	COG0837	glucose binding
E1742_RS22000	COG1737	Transcriptional regulator
E1742_RS22005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E1742_RS22015	COG0779	Required for maturation of 30S ribosomal subunits
E1742_RS22020	COG0195	Participates in both transcription termination and antitermination
E1742_RS22020	COG2251	uridine kinase activity
E1742_RS22025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E1742_RS22030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E1742_RS22045	COG2205	protein histidine kinase activity
E1742_RS22050	COG1217	gtp-binding protein TYPA
E1742_RS22060	COG3940	Belongs to the glycosyl hydrolase 43 family
E1742_RS22075	COG1070	Carbohydrate kinase
E1742_RS22080	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1742_RS22085	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1742_RS22090	COG1129	ABC transporter
E1742_RS22095	COG1879	ABC-type sugar transport system periplasmic component
E1742_RS22105	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS22105	COG3347	Dehydrogenase
E1742_RS22110	COG4952	isomerase
E1742_RS22125	COG3254	rhamnose metabolic process
E1742_RS22130	COG0657	acetylesterase activity
E1742_RS22130	COG2755	lipolytic protein G-D-S-L family
E1742_RS22140	COG2755	lipolytic protein G-D-S-L family
E1742_RS22145	COG3401	FG-GAP repeat protein
E1742_RS22150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E1742_RS22165	COG3401	FG-GAP repeat protein
E1742_RS22175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E1742_RS22180	COG0840	transmembrane signaling receptor activity
E1742_RS22220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E1742_RS22235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E1742_RS22240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E1742_RS22260	COG2271	Major facilitator Superfamily
E1742_RS22265	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS22325	COG3300	MHYT domain
E1742_RS22325	COG5001	Diguanylate cyclase
E1742_RS22355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E1742_RS22360	COG2814	Major facilitator Superfamily
E1742_RS22365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E1742_RS22370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E1742_RS22370	COG2205	protein histidine kinase activity
E1742_RS22400	COG4771	TonB-dependent receptor
E1742_RS22405	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS22420	COG1704	LemA family
E1742_RS22425	COG0284	orotidine-5'-phosphate decarboxylase activity
E1742_RS22430	COG2925	Exonuclease
E1742_RS22445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E1742_RS22490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E1742_RS22495	COG0484	heat shock protein binding
E1742_RS22535	COG0583	DNA-binding transcription factor activity
E1742_RS22540	COG2814	Major facilitator Superfamily
E1742_RS22550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E1742_RS22555	COG0584	glycerophosphoryl diester phosphodiesterase
E1742_RS22565	COG0425	Belongs to the sulfur carrier protein TusA family
E1742_RS22570	COG2086	electron transfer activity
E1742_RS22580	COG1960	acyl-CoA dehydrogenase activity
E1742_RS22590	COG1280	lysine exporter protein (LysE YggA)
E1742_RS22605	COG0228	four-way junction DNA binding
E1742_RS22610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E1742_RS22615	COG0336	Belongs to the RNA methyltransferase TrmD family
E1742_RS22620	COG0335	large ribosomal subunit rRNA binding
E1742_RS22630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E1742_RS22645	COG2188	Transcriptional regulator
E1742_RS22695	COG0395	ABC-type sugar transport system, permease component
E1742_RS22700	COG1175	transmembrane transport
E1742_RS22715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E1742_RS22720	COG2188	Transcriptional regulator
E1742_RS22740	COG3409	Peptidoglycan-binding domain 1 protein
E1742_RS22740	COG3267	Type II secretory pathway component ExeA
E1742_RS22770	COG3220	belongs to the UPF0276 family
E1742_RS22785	COG0114	fumarate hydratase activity
E1742_RS22855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E1742_RS22865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E1742_RS22875	COG2329	Antibiotic biosynthesis monooxygenase
E1742_RS22910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E1742_RS22930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E1742_RS22940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E1742_RS22945	COG0287	Prephenate dehydrogenase
E1742_RS22950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E1742_RS22955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E1742_RS22965	COG0776	regulation of translation
E1742_RS22975	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E1742_RS22980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E1742_RS22995	COG0492	ferredoxin-NADP+ reductase activity
E1742_RS23020	COG2951	lytic endotransglycosylase activity
E1742_RS23035	COG0714	Associated with various cellular activities
E1742_RS23040	COG0123	including yeast histone deacetylase and acetoin utilization protein
E1742_RS23050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E1742_RS23080	COG0840	transmembrane signaling receptor activity
E1742_RS23090	COG4214	carbohydrate transport
E1742_RS23095	COG1129	ABC transporter
E1742_RS23100	COG4213	ABC transporter substrate-binding protein
E1742_RS23105	COG0129	dihydroxy-acid dehydratase activity
E1742_RS23110	COG3386	PFAM SMP-30 Gluconolaconase
E1742_RS23125	COG4948	Mandelate Racemase Muconate Lactonizing
E1742_RS23135	COG3507	Belongs to the glycosyl hydrolase 43 family
E1742_RS23145	COG3661	Belongs to the glycosyl hydrolase 67 family
E1742_RS23165	COG1289	transmembrane transporter activity
E1742_RS23170	COG1846	Transcriptional regulator
E1742_RS23190	COG2271	Major facilitator Superfamily
E1742_RS23195	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS23205	COG1028	Short-chain dehydrogenase reductase Sdr
E1742_RS23210	COG5652	VanZ like family
E1742_RS23215	COG0667	Aldo Keto reductase
E1742_RS23220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E1742_RS23225	COG1570	exodeoxyribonuclease VII activity
E1742_RS23230	COG0811	peptide transport
E1742_RS23235	COG0848	biopolymer transport protein
E1742_RS23240	COG1663	tetraacyldisaccharide 4'-kinase activity
E1742_RS23245	COG2835	tetraacyldisaccharide 4'-kinase activity
E1742_RS23250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E1742_RS23255	COG0563	adenylate kinase activity
E1742_RS23275	COG0405	Gamma-glutamyltransferase
E1742_RS23295	COG0745	RESPONSE REGULATOR receiver
E1742_RS23315	COG1024	Enoyl-CoA hydratase
E1742_RS23320	COG1960	acyl-CoA dehydrogenase activity
E1742_RS23330	COG1045	serine acetyltransferase
E1742_RS23345	COG0488	(ABC) transporter
E1742_RS23375	COG1596	polysaccharide export
E1742_RS23380	COG0489	protein tyrosine kinase activity
E1742_RS23380	COG3206	protein involved in exopolysaccharide biosynthesis
E1742_RS23465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E1742_RS23470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E1742_RS23565	COG0728	peptidoglycan biosynthetic process
E1742_RS23570	COG0268	Binds directly to 16S ribosomal RNA
E1742_RS23585	COG1187	pseudouridine synthase activity
E1742_RS23595	COG1794	racemase activity, acting on amino acids and derivatives
E1742_RS23620	COG1278	Cold shock
E1742_RS23625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E1742_RS23630	COG0542	response to heat
E1742_RS23645	COG4946	Tricorn protease homolog
E1742_RS23645	COG0793	Belongs to the peptidase S41A family
E1742_RS23650	COG3829	transcription factor binding
E1742_RS23705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E1742_RS23750	COG1648	precorrin-2 dehydrogenase activity
E1742_RS23750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E1742_RS23765	COG0175	sulfate reduction
E1742_RS23775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E1742_RS23780	COG0583	DNA-binding transcription factor activity
E1742_RS23785	COG2226	methyltransferase
E1742_RS23810	COG3275	phosphorelay sensor kinase activity
E1742_RS23850	COG1012	belongs to the aldehyde dehydrogenase family
E1742_RS23860	COG3791	Glutathione-dependent formaldehyde-activating
E1742_RS23875	COG2010	Cytochrome c
E1742_RS23900	COG3284	Transcriptional regulator
E1742_RS23920	COG2070	2-Nitropropane dioxygenase
E1742_RS23925	COG1666	GTP binding
E1742_RS23930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E1742_RS23935	COG5001	Diguanylate cyclase
E1742_RS23935	COG4251	negative regulation of phosphorylation
E1742_RS23935	COG3706	GGDEF domain
E1742_RS23935	COG2203	Gaf domain
E1742_RS23940	COG2201	protein-glutamate methylesterase activity
E1742_RS23965	COG0840	transmembrane signaling receptor activity
E1742_RS23965	COG0840	transmembrane signaling receptor activity
E1742_RS23970	COG0137	argininosuccinate synthase activity
E1742_RS23975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E1742_RS23985	COG1162	GTPase activity
E1742_RS23990	COG0501	Belongs to the peptidase M48B family
E1742_RS23995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E1742_RS24010	COG3318	Belongs to the UPF0149 family
E1742_RS24010	COG3012	SEC-C Motif Domain Protein
E1742_RS24015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E1742_RS24040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS24060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E1742_RS24105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E1742_RS24115	COG2814	Major facilitator Superfamily
E1742_RS24130	COG1739	Uncharacterized protein family UPF0029
E1742_RS24185	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E1742_RS24195	COG0823	Involved in the tonB-independent uptake of proteins
E1742_RS24215	COG0824	Thioesterase
E1742_RS24220	COG4221	oxidoreductase activity
E1742_RS24225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E1742_RS24230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E1742_RS24265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E1742_RS24265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E1742_RS24275	COG0840	transmembrane signaling receptor activity
E1742_RS24285	COG1764	response to oxidative stress
E1742_RS24310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E1742_RS24315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E1742_RS24325	COG0741	lytic transglycosylase activity
E1742_RS24330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E1742_RS24345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E1742_RS24350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E1742_RS24360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E1742_RS24390	COG2879	small protein
E1742_RS24395	COG1966	Carbon starvation protein
E1742_RS24505	COG2755	lipolytic protein G-D-S-L family
E1742_RS24505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E1742_RS24520	COG0023	Translation Initiation Factor
E1742_RS24525	COG2610	gluconate transmembrane transporter activity
E1742_RS24555	COG2205	protein histidine kinase activity
E1742_RS24605	COG0671	phosphoesterase, PA-phosphatase related
E1742_RS24610	COG1597	lipid kinase activity
E1742_RS24615	COG1408	metallophosphoesterase
E1742_RS24630	COG0427	acetyl-CoA hydrolase
E1742_RS24640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E1742_RS24685	COG2982	Protein involved in outer membrane biogenesis
E1742_RS24760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E1742_RS24760	COG2885	chlorophyll binding
E1742_RS24800	COG3622	Belongs to the hyi family
E1742_RS24805	COG0513	Belongs to the DEAD box helicase family
E1742_RS24810	COG0483	inositol monophosphate 1-phosphatase activity
E1742_RS24845	COG1309	transcriptional regulator
E1742_RS24855	COG0625	glutathione transferase activity
E1742_RS24860	COG1451	nucleotide metabolic process
E1742_RS24865	COG0322	excinuclease ABC activity
E1742_RS24870	COG0572	uridine kinase
E1742_RS24875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E1742_RS24880	COG0725	ABC transporter, periplasmic molybdate-binding protein
E1742_RS24885	COG4149	molybdate abc transporter
E1742_RS24890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E1742_RS24985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E1742_RS24995	COG2824	Alkylphosphonate utilization operon protein PhnA
E1742_RS25010	COG5652	VanZ like family
E1742_RS25015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E1742_RS25020	COG0181	hydroxymethylbilane synthase activity
E1742_RS25030	COG2959	enzyme of heme biosynthesis
E1742_RS25040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E1742_RS25065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1742_RS25085	COG3210	domain, Protein
E1742_RS25100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E1742_RS25100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E1742_RS25105	COG0347	Belongs to the P(II) protein family
E1742_RS25110	COG2860	membrane
E1742_RS25115	COG2840	Smr protein MutS2
E1742_RS25120	COG0492	ferredoxin-NADP+ reductase activity
E1742_RS25125	COG1674	ftsk spoiiie
E1742_RS25130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E1742_RS25135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E1742_RS25160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E1742_RS25175	COG1879	ABC-type sugar transport system periplasmic component
E1742_RS25180	COG1271	oxidase subunit
E1742_RS25185	COG1294	oxidase, subunit
E1742_RS25205	COG0243	molybdopterin cofactor binding
E1742_RS25205	COG3383	formate dehydrogenase (NAD+) activity
E1742_RS25210	COG0437	4 iron, 4 sulfur cluster binding
E1742_RS25260	COG4771	TonB-dependent receptor
E1742_RS25280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E1742_RS25305	COG0612	Peptidase, M16
E1742_RS25310	COG1607	acyl-coa hydrolase
E1742_RS25320	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E1742_RS25345	COG2205	protein histidine kinase activity
E1742_RS25345	COG4999	Histidine kinase
E1742_RS25345	COG3437	response regulator, receiver
E1742_RS25345	COG3850	Histidine kinase
E1742_RS25370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E1742_RS25385	COG3639	organic phosphonate transmembrane transporter activity
E1742_RS25390	COG3639	organic phosphonate transmembrane transporter activity
E1742_RS25405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E1742_RS25410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E1742_RS25415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E1742_RS25420	COG0709	Synthesizes selenophosphate from selenide and ATP
E1742_RS25430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E1742_RS25440	COG0823	Involved in the tonB-independent uptake of proteins
E1742_RS25440	COG1506	peptidase
E1742_RS25445	COG0753	catalase activity
E1742_RS25450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E1742_RS25480	COG1376	ErfK ybiS ycfS ynhG family protein
E1742_RS25485	COG0513	Belongs to the DEAD box helicase family
E1742_RS25495	COG1388	LysM domain
E1742_RS25495	COG0741	lytic transglycosylase activity
E1742_RS25555	COG1214	PFAM Peptidase M22, glycoprotease
E1742_RS25575	COG0477	Major facilitator Superfamily
E1742_RS25580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E1742_RS25595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E1742_RS25615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E1742_RS25620	COG0573	inorganic phosphate transmembrane transporter activity
E1742_RS25630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E1742_RS25635	COG0704	Plays a role in the regulation of phosphate uptake
E1742_RS25645	COG5002	protein histidine kinase activity
E1742_RS25650	COG1752	Esterase of the alpha-beta hydrolase superfamily
E1742_RS25655	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E1742_RS25670	COG0505	Belongs to the CarA family
E1742_RS25675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E1742_RS25680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E1742_RS25695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E1742_RS25700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E1742_RS25705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E1742_RS25710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E1742_RS25775	COG0243	molybdopterin cofactor binding
E1742_RS25775	COG3383	formate dehydrogenase (NAD+) activity
E1742_RS25780	COG0437	4 iron, 4 sulfur cluster binding
E1742_RS25800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E1742_RS25815	COG0583	DNA-binding transcription factor activity
E1742_RS25830	COG3275	phosphorelay sensor kinase activity
E1742_RS25835	COG3279	Response regulator of the LytR AlgR family
E1742_RS25860	COG4191	Histidine kinase
E1742_RS25890	COG0557	exoribonuclease II activity
E1742_RS25895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E1742_RS25900	COG1045	serine acetyltransferase
E1742_RS25905	COG3132	Protein of unknown function, DUF480
E1742_RS25950	COG1131	(ABC) transporter
E1742_RS25955	COG1725	Transcriptional regulator
E1742_RS25970	COG1902	pentaerythritol trinitrate reductase activity
E1742_RS25990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E1742_RS26005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides