locus-tag	class	description
MESIL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MESIL_RS00010	COG0592	DNA-directed DNA polymerase activity
MESIL_RS00015	COG0148	phosphopyruvate hydratase activity
MESIL_RS00020	COG0469	pyruvate kinase activity
MESIL_RS00025	COG2124	cytochrome p450
MESIL_RS00065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MESIL_RS00070	COG0347	Belongs to the P(II) protein family
MESIL_RS00075	COG0004	ammonium transporteR
MESIL_RS00080	COG1420	regulation of RNA biosynthetic process
MESIL_RS00085	COG0142	geranyltranstransferase activity
MESIL_RS00090	COG1842	Phage shock protein A
MESIL_RS00110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MESIL_RS00115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MESIL_RS00135	COG1388	LysM domain
MESIL_RS00135	COG3858	chitin binding
MESIL_RS00160	COG0243	molybdopterin cofactor binding
MESIL_RS00180	COG4187	Peptidase family M20/M25/M40
MESIL_RS00185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MESIL_RS00200	COG1172	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS00205	COG1879	ABC-type sugar transport system periplasmic component
MESIL_RS00220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MESIL_RS00270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MESIL_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS00310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MESIL_RS00325	COG4585	Histidine kinase
MESIL_RS00330	COG2197	response regulator
MESIL_RS00335	COG1185	polyribonucleotide nucleotidyltransferase activity
MESIL_RS00340	COG1960	acyl-CoA dehydrogenase activity
MESIL_RS00350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MESIL_RS00355	COG0303	'Molybdopterin
MESIL_RS00360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MESIL_RS00365	COG0667	Aldo Keto reductase
MESIL_RS00375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MESIL_RS00380	COG2720	vancomycin resistance protein
MESIL_RS00395	COG0601	transmembrane transport
MESIL_RS00400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS00410	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MESIL_RS00415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MESIL_RS00420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MESIL_RS00425	COG1404	Belongs to the peptidase S8 family
MESIL_RS00455	COG0442	prolyl-tRNA aminoacylation
MESIL_RS00460	COG0673	inositol 2-dehydrogenase activity
MESIL_RS00465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MESIL_RS00480	COG0318	PFAM AMP-dependent synthetase and ligase
MESIL_RS00500	COG0497	DNA recombination
MESIL_RS00510	COG0517	IMP dehydrogenase activity
MESIL_RS00515	COG0589	response to stress
MESIL_RS00545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MESIL_RS00550	COG0497	DNA recombination
MESIL_RS00565	COG0556	nucleotide-excision repair
MESIL_RS00590	COG2309	aminopeptidase activity
MESIL_RS00600	COG2183	response to ionizing radiation
MESIL_RS00600	COG0539	negative regulation of cytoplasmic translation
MESIL_RS00610	COG2239	Acts as a magnesium transporter
MESIL_RS00615	COG0475	glutathione-regulated potassium exporter activity
MESIL_RS00630	COG3942	CHAP domain
MESIL_RS00630	COG1388	LysM domain
MESIL_RS00635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MESIL_RS00645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MESIL_RS00650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MESIL_RS00655	COG0105	UTP biosynthetic process
MESIL_RS00660	COG0515	serine threonine protein kinase
MESIL_RS00660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MESIL_RS00670	COG1937	Protein conserved in bacteria
MESIL_RS00675	COG2217	Heavy metal translocating P-type atpase
MESIL_RS00685	COG2217	Heavy metal translocating P-type atpase
MESIL_RS00710	COG2132	Multicopper oxidase
MESIL_RS00720	COG5002	protein histidine kinase activity
MESIL_RS00725	COG0745	RESPONSE REGULATOR receiver
MESIL_RS00765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MESIL_RS00780	COG1063	alcohol dehydrogenase
MESIL_RS00785	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS00790	COG1063	alcohol dehydrogenase
MESIL_RS00810	COG1609	Transcriptional regulator
MESIL_RS00815	COG0738	Major facilitator superfamily
MESIL_RS00820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MESIL_RS00835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MESIL_RS00840	COG0446	pyridine nucleotide-disulphide oxidoreductase
MESIL_RS00845	COG0425	Belongs to the sulfur carrier protein TusA family
MESIL_RS00860	COG0205	6-phosphofructokinase activity
MESIL_RS00880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MESIL_RS00890	COG1217	gtp-binding protein TYPA
MESIL_RS00895	COG0009	L-threonylcarbamoyladenylate synthase
MESIL_RS00900	COG2967	ApaG domain
MESIL_RS00910	COG2318	DinB family
MESIL_RS00915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MESIL_RS00925	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MESIL_RS00975	COG0579	oxidoreductase
MESIL_RS00990	COG0739	heme binding
MESIL_RS00990	COG1196	nuclear chromosome segregation
MESIL_RS00990	COG0741	lytic transglycosylase activity
MESIL_RS00995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MESIL_RS01000	COG0825	malonyl-CoA metabolic process
MESIL_RS01020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MESIL_RS01040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MESIL_RS01110	COG1136	(ABC) transporter
MESIL_RS01115	COG1136	(ABC) transporter
MESIL_RS01115	COG0577	efflux transmembrane transporter activity
MESIL_RS01120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MESIL_RS01125	COG0516	GMP reductase activity
MESIL_RS01135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MESIL_RS01140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MESIL_RS01145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MESIL_RS01155	COG3540	Alkaline phosphatase
MESIL_RS01160	COG0589	response to stress
MESIL_RS01170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MESIL_RS01205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MESIL_RS01250	COG2181	nitrate reductase activity
MESIL_RS01265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MESIL_RS01270	COG2010	Cytochrome c
MESIL_RS01295	COG1672	PFAM Archaeal ATPase
MESIL_RS01295	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MESIL_RS01325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MESIL_RS01330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MESIL_RS01350	COG2151	metal-sulfur cluster biosynthetic enzyme
MESIL_RS01365	COG1832	CoA-binding protein
MESIL_RS01375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MESIL_RS01380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MESIL_RS01380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MESIL_RS01410	COG1472	Belongs to the glycosyl hydrolase 3 family
MESIL_RS01415	COG1737	Transcriptional regulator
MESIL_RS01425	COG1175	transmembrane transport
MESIL_RS01430	COG0395	ABC-type sugar transport system, permease component
MESIL_RS01445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MESIL_RS01450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MESIL_RS01455	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MESIL_RS01465	COG1902	pentaerythritol trinitrate reductase activity
MESIL_RS01495	COG2086	electron transfer activity
MESIL_RS01500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MESIL_RS01520	COG0477	Major facilitator Superfamily
MESIL_RS01550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MESIL_RS01580	COG2258	MOSC domain
MESIL_RS01595	COG2226	methyltransferase
MESIL_RS01605	COG0019	diaminopimelate decarboxylase activity
MESIL_RS01610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MESIL_RS01640	COG1850	ribulose-bisphosphate carboxylase activity
MESIL_RS01645	COG0662	Cupin 2, conserved barrel domain protein
MESIL_RS01650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MESIL_RS01655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MESIL_RS01670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MESIL_RS01675	COG1660	Displays ATPase and GTPase activities
MESIL_RS01685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MESIL_RS01690	COG3300	MHYT domain
MESIL_RS01690	COG5001	Diguanylate cyclase
MESIL_RS01700	COG0314	molybdopterin synthase activity
MESIL_RS01705	COG0187	DNA topoisomerase II activity
MESIL_RS01725	COG1216	Glycosyl transferase, family 2
MESIL_RS01725	COG0463	Glycosyl transferase, family 2
MESIL_RS01730	COG1216	Glycosyl transferase, family 2
MESIL_RS01735	COG0512	Glutamine amidotransferase of anthranilate synthase
MESIL_RS01740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MESIL_RS01745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MESIL_RS01765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MESIL_RS01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MESIL_RS01775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MESIL_RS01785	COG0285	dihydrofolate synthase activity
MESIL_RS01795	COG0181	hydroxymethylbilane synthase activity
MESIL_RS01810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MESIL_RS01820	COG0792	nuclease activity
MESIL_RS01825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MESIL_RS01830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MESIL_RS01845	COG1131	(ABC) transporter
MESIL_RS01865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MESIL_RS01870	COG2022	thiamine diphosphate biosynthetic process
MESIL_RS01875	COG2104	thiamine diphosphate biosynthetic process
MESIL_RS01880	COG0352	thiamine-phosphate diphosphorylase activity
MESIL_RS01885	COG0515	serine threonine protein kinase
MESIL_RS01885	COG2815	serine threonine protein kinase
MESIL_RS01895	COG1404	Belongs to the peptidase S8 family
MESIL_RS01920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MESIL_RS01950	COG0492	ferredoxin-NADP+ reductase activity
MESIL_RS01955	COG1505	serine-type exopeptidase activity
MESIL_RS01960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MESIL_RS01965	COG0612	Peptidase, M16
MESIL_RS01975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MESIL_RS01980	COG1937	Protein conserved in bacteria
MESIL_RS01990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MESIL_RS02000	COG0778	Nitroreductase
MESIL_RS02005	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MESIL_RS02015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MESIL_RS02035	COG1252	NADH dehydrogenase
MESIL_RS02040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MESIL_RS02060	COG0071	Belongs to the small heat shock protein (HSP20) family
MESIL_RS02070	COG0457	Tetratricopeptide repeat
MESIL_RS02070	COG0705	Rhomboid family
MESIL_RS02075	COG0475	glutathione-regulated potassium exporter activity
MESIL_RS02080	COG0490	domain, Protein
MESIL_RS02085	COG3431	PFAM Phosphate-starvation-inducible E
MESIL_RS02120	COG2193	ferroxidase activity
MESIL_RS02130	COG0154	amidase activity
MESIL_RS02155	COG0488	(ABC) transporter
MESIL_RS02160	COG0667	Aldo Keto reductase
MESIL_RS02165	COG0412	Dienelactone hydrolase
MESIL_RS02170	COG0789	Transcriptional regulator
MESIL_RS02175	COG0484	heat shock protein binding
MESIL_RS02185	COG0443	Heat shock 70 kDa protein
MESIL_RS02190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MESIL_RS02195	COG0783	Belongs to the Dps family
MESIL_RS02200	COG0776	regulation of translation
MESIL_RS02205	COG0204	Acyl-transferase
MESIL_RS02205	COG0318	PFAM AMP-dependent synthetase and ligase
MESIL_RS02210	COG1543	Belongs to the glycosyl hydrolase 57 family
MESIL_RS02220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MESIL_RS02225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MESIL_RS02230	COG0730	response to heat
MESIL_RS02235	COG0189	ligase activity
MESIL_RS02250	COG0066	3-isopropylmalate dehydratase activity
MESIL_RS02255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MESIL_RS02260	COG1598	PFAM Uncharacterised protein family UPF0150
MESIL_RS02270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MESIL_RS02275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MESIL_RS02280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MESIL_RS02290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MESIL_RS02325	COG1472	Belongs to the glycosyl hydrolase 3 family
MESIL_RS02350	COG2197	response regulator
MESIL_RS02375	COG1231	oxidoreductase activity
MESIL_RS02380	COG0604	alcohol dehydrogenase
MESIL_RS02395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MESIL_RS02430	COG0395	ABC-type sugar transport system, permease component
MESIL_RS02450	COG4948	Mandelate Racemase Muconate Lactonizing
MESIL_RS02470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MESIL_RS02590	COG0741	lytic transglycosylase activity
MESIL_RS02595	COG3854	ATPases associated with a variety of cellular activities
MESIL_RS02660	COG2801	Transposase and inactivated derivatives
MESIL_RS02670	COG5654	RES domain protein
MESIL_RS02715	COG0667	Aldo Keto reductase
MESIL_RS02730	COG2124	cytochrome p450
MESIL_RS02870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MESIL_RS02895	COG1525	nuclease
MESIL_RS02940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MESIL_RS02945	COG2409	Drug exporters of the RND superfamily
MESIL_RS02970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MESIL_RS02980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MESIL_RS02985	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MESIL_RS02990	COG1496	oxidoreductase activity
MESIL_RS03000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MESIL_RS03020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MESIL_RS03025	COG0400	carboxylic ester hydrolase activity
MESIL_RS03030	COG0346	lactoylglutathione lyase activity
MESIL_RS03045	COG1733	regulation of RNA biosynthetic process
MESIL_RS03055	COG0459	protein refolding
MESIL_RS03060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MESIL_RS03065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MESIL_RS03090	COG0166	Belongs to the GPI family
MESIL_RS03110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MESIL_RS03125	COG1595	DNA-templated transcription, initiation
MESIL_RS03140	COG1612	heme a metabolic process
MESIL_RS03140	COG0109	protoheme IX farnesyltransferase activity
MESIL_RS03145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MESIL_RS03145	COG2010	Cytochrome c
MESIL_RS03150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MESIL_RS03150	COG1845	cytochrome c oxidase, subunit III
MESIL_RS03225	COG2226	methyltransferase
MESIL_RS03230	COG4603	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS03235	COG1079	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS03260	COG2199	diguanylate cyclase activity
MESIL_RS03265	COG4106	trans-aconitate 2-methyltransferase activity
MESIL_RS03270	COG0494	nUDIX hydrolase
MESIL_RS03295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MESIL_RS03305	COG0581	inorganic phosphate transmembrane transporter activity
MESIL_RS03310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MESIL_RS03325	COG0012	GTP binding
MESIL_RS03335	COG2005	Transcriptional regulator
MESIL_RS03335	COG3585	molybdate ion transport
MESIL_RS03350	COG1181	Belongs to the D-alanine--D-alanine ligase family
MESIL_RS03360	COG0193	aminoacyl-tRNA hydrolase activity
MESIL_RS03365	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MESIL_RS03370	COG0366	Alpha amylase catalytic
MESIL_RS03375	COG1082	Xylose isomerase domain protein TIM barrel
MESIL_RS03385	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MESIL_RS03390	COG3842	ATPase activity
MESIL_RS03410	COG1609	Transcriptional regulator
MESIL_RS03415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MESIL_RS03425	COG0586	Pfam SNARE associated Golgi protein
MESIL_RS03455	COG0346	lactoylglutathione lyase activity
MESIL_RS03500	COG0803	Belongs to the bacterial solute-binding protein 9 family
MESIL_RS03505	COG1121	(ABC) transporter
MESIL_RS03510	COG1321	iron dependent repressor
MESIL_RS03510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MESIL_RS03515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MESIL_RS03520	COG1472	Belongs to the glycosyl hydrolase 3 family
MESIL_RS03540	COG2017	converts alpha-aldose to the beta-anomer
MESIL_RS03545	COG1070	Carbohydrate kinase
MESIL_RS03570	COG1337	RAMP superfamily
MESIL_RS03610	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MESIL_RS03635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MESIL_RS03640	COG1126	abc transporter atp-binding protein
MESIL_RS03655	COG0765	amino acid transport
MESIL_RS03685	COG0513	Belongs to the DEAD box helicase family
MESIL_RS03700	COG3011	Protein conserved in bacteria
MESIL_RS03705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MESIL_RS03715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MESIL_RS03725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MESIL_RS03750	COG1802	Transcriptional regulator
MESIL_RS03755	COG1187	pseudouridine synthase activity
MESIL_RS03760	COG2205	protein histidine kinase activity
MESIL_RS03765	COG0745	RESPONSE REGULATOR receiver
MESIL_RS03775	COG0477	Major facilitator Superfamily
MESIL_RS03795	COG0717	Belongs to the dCTP deaminase family
MESIL_RS03800	COG0010	Belongs to the arginase family
MESIL_RS03805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MESIL_RS03810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MESIL_RS03820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MESIL_RS03825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MESIL_RS03830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MESIL_RS03835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MESIL_RS03850	COG0799	negative regulation of ribosome biogenesis
MESIL_RS03895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MESIL_RS03900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MESIL_RS03905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MESIL_RS03910	COG1854	S-ribosylhomocysteine lyase activity
MESIL_RS03920	COG0569	domain protein
MESIL_RS03925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MESIL_RS03940	COG2313	pseudouridylate synthase activity
MESIL_RS03950	COG3001	Fructosamine kinase
MESIL_RS03955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MESIL_RS03960	COG0366	Alpha amylase catalytic
MESIL_RS03975	COG0277	FAD linked oxidase domain protein
MESIL_RS03985	COG0667	Aldo Keto reductase
MESIL_RS04000	COG1733	regulation of RNA biosynthetic process
MESIL_RS04005	COG2910	NAD(P)H-binding
MESIL_RS04020	COG1131	(ABC) transporter
MESIL_RS04030	COG1131	(ABC) transporter
MESIL_RS04040	COG1725	Transcriptional regulator
MESIL_RS04045	COG1131	(ABC) transporter
MESIL_RS04085	COG1136	(ABC) transporter
MESIL_RS04090	COG0577	efflux transmembrane transporter activity
MESIL_RS04090	COG1136	(ABC) transporter
MESIL_RS04100	COG1067	ATP-dependent peptidase activity
MESIL_RS04105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MESIL_RS04130	COG0297	glycogen (starch) synthase activity
MESIL_RS04140	COG2323	membrane
MESIL_RS04145	COG0456	acetyltransferase
MESIL_RS04150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MESIL_RS04165	COG1116	anion transmembrane transporter activity
MESIL_RS04170	COG3850	Histidine kinase
MESIL_RS04170	COG5002	protein histidine kinase activity
MESIL_RS04185	COG0085	RNA polymerase activity
MESIL_RS04190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MESIL_RS04205	COG2267	carboxylic ester hydrolase activity
MESIL_RS04225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MESIL_RS04230	COG0359	binds to the 23S rRNA
MESIL_RS04240	COG0321	lipoyl(octanoyl) transferase activity
MESIL_RS04245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MESIL_RS04255	COG0366	Alpha amylase catalytic
MESIL_RS04260	COG2084	Dehydrogenase
MESIL_RS04275	COG0704	Plays a role in the regulation of phosphate uptake
MESIL_RS04280	COG2205	protein histidine kinase activity
MESIL_RS04320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MESIL_RS04330	COG0482	sulfurtransferase activity
MESIL_RS04350	COG0354	folic acid binding
MESIL_RS04355	COG1546	Belongs to the CinA family
MESIL_RS04355	COG1058	Belongs to the CinA family
MESIL_RS04360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MESIL_RS04365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MESIL_RS04370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MESIL_RS04370	COG1418	mRNA catabolic process
MESIL_RS04380	COG1077	Cell shape determining protein MreB Mrl
MESIL_RS04385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MESIL_RS04390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MESIL_RS04395	COG0673	inositol 2-dehydrogenase activity
MESIL_RS04400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MESIL_RS04405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MESIL_RS04425	COG2197	response regulator
MESIL_RS04470	COG1115	amino acid carrier protein
MESIL_RS04475	COG0163	prenyltransferase activity
MESIL_RS04480	COG1968	undecaprenyl-diphosphatase activity
MESIL_RS04485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MESIL_RS04490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MESIL_RS04510	COG2165	general secretion pathway protein
MESIL_RS04515	COG2165	general secretion pathway protein
MESIL_RS04520	COG4636	protein conserved in cyanobacteria
MESIL_RS04530	COG5001	Diguanylate cyclase
MESIL_RS04530	COG3300	MHYT domain
MESIL_RS04535	COG1595	DNA-templated transcription, initiation
MESIL_RS04600	COG1732	Glycine betaine
MESIL_RS04605	COG1174	glycine betaine transport
MESIL_RS04610	COG0517	IMP dehydrogenase activity
MESIL_RS04610	COG1125	glycine betaine transport
MESIL_RS04615	COG1174	glycine betaine transport
MESIL_RS04645	COG1131	(ABC) transporter
MESIL_RS04655	COG0315	cyclic pyranopterin monophosphate synthase activity
MESIL_RS04665	COG1482	cell wall glycoprotein biosynthetic process
MESIL_RS04715	COG3842	ATPase activity
MESIL_RS04725	COG5002	protein histidine kinase activity
MESIL_RS04730	COG0785	Cytochrome C biogenesis protein
MESIL_RS04735	COG1131	(ABC) transporter
MESIL_RS04750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MESIL_RS04755	COG1138	Cytochrome C-type biogenesis protein
MESIL_RS04760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MESIL_RS04765	COG3088	subunit of a heme lyase
MESIL_RS04780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MESIL_RS04795	COG0268	Binds directly to 16S ribosomal RNA
MESIL_RS04805	COG0083	homoserine kinase activity
MESIL_RS04810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MESIL_RS04810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MESIL_RS04815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MESIL_RS04820	COG1160	GTP binding
MESIL_RS04835	COG0395	ABC-type sugar transport system, permease component
MESIL_RS04850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MESIL_RS04865	COG0517	IMP dehydrogenase activity
MESIL_RS04870	COG0123	including yeast histone deacetylase and acetoin utilization protein
MESIL_RS04890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MESIL_RS04905	COG1278	Cold shock
MESIL_RS04910	COG0484	heat shock protein binding
MESIL_RS04935	COG2808	Putative FMN-binding domain
MESIL_RS04940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MESIL_RS04950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MESIL_RS04960	COG0534	Mate efflux family protein
MESIL_RS04965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MESIL_RS04970	COG3265	gluconokinase activity
MESIL_RS04985	COG0793	Belongs to the peptidase S41A family
MESIL_RS04990	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MESIL_RS05015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MESIL_RS05015	COG2169	Transcriptional regulator
MESIL_RS05020	COG0697	spore germination
MESIL_RS05030	COG0673	inositol 2-dehydrogenase activity
MESIL_RS05035	COG3718	enzyme involved in inositol metabolism
MESIL_RS05045	COG1349	DNA-binding transcription factor activity
MESIL_RS05050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MESIL_RS05050	COG0574	Belongs to the PEP-utilizing enzyme family
MESIL_RS05055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MESIL_RS05065	COG1132	(ABC) transporter
MESIL_RS05070	COG0822	iron-sulfur transferase activity
MESIL_RS05075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MESIL_RS05085	COG0719	Fe-S assembly protein
MESIL_RS05090	COG0719	Fe-S assembly protein
MESIL_RS05095	COG0396	ATPase activity
MESIL_RS05110	COG1802	Transcriptional regulator
MESIL_RS05115	COG2721	sulfolactate sulfo-lyase activity
MESIL_RS05120	COG2721	sulfolactate sulfo-lyase activity
MESIL_RS05125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MESIL_RS05130	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MESIL_RS05135	COG1653	transport
MESIL_RS05140	COG1175	transmembrane transport
MESIL_RS05155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MESIL_RS05160	COG3684	Belongs to the aldolase LacD family
MESIL_RS05175	COG0346	lactoylglutathione lyase activity
MESIL_RS05205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MESIL_RS05225	COG0495	leucyl-tRNA aminoacylation
MESIL_RS05245	COG0745	RESPONSE REGULATOR receiver
MESIL_RS05255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MESIL_RS05265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MESIL_RS05270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MESIL_RS05270	COG0758	DNA mediated transformation
MESIL_RS05275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MESIL_RS05280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MESIL_RS05285	COG0110	maltose O-acetyltransferase activity
MESIL_RS05315	COG4585	Histidine kinase
MESIL_RS05320	COG2197	response regulator
MESIL_RS05330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MESIL_RS05335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MESIL_RS05345	COG0047	phosphoribosylformylglycinamidine synthase activity
MESIL_RS05355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MESIL_RS05360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MESIL_RS05370	COG0577	efflux transmembrane transporter activity
MESIL_RS05370	COG1136	(ABC) transporter
MESIL_RS05375	COG1136	(ABC) transporter
MESIL_RS05400	COG0745	RESPONSE REGULATOR receiver
MESIL_RS05405	COG2205	protein histidine kinase activity
MESIL_RS05420	COG1051	belongs to the nudix hydrolase family
MESIL_RS05430	COG1278	Cold shock
MESIL_RS05440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MESIL_RS05455	COG2860	membrane
MESIL_RS05460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MESIL_RS05480	COG0306	phosphate transporter
MESIL_RS05485	COG1392	Phosphate transport regulator
MESIL_RS05490	COG1960	acyl-CoA dehydrogenase activity
MESIL_RS05500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MESIL_RS05505	COG1047	Peptidyl-prolyl cis-trans
MESIL_RS05540	COG1139	Iron-sulfur cluster binding protein
MESIL_RS05545	COG0247	lactate metabolic process
MESIL_RS05550	COG2819	hydrolase of the alpha beta superfamily
MESIL_RS05585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MESIL_RS05595	COG2409	Drug exporters of the RND superfamily
MESIL_RS05600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MESIL_RS05605	COG0517	IMP dehydrogenase activity
MESIL_RS05605	COG0516	GMP reductase activity
MESIL_RS05625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MESIL_RS05630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MESIL_RS05645	COG1164	Oligoendopeptidase f
MESIL_RS05655	COG1404	Belongs to the peptidase S8 family
MESIL_RS05660	COG2096	Adenosyltransferase
MESIL_RS05665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MESIL_RS05685	COG1268	BioY protein
MESIL_RS05690	COG1335	isochorismatase
MESIL_RS05695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MESIL_RS05720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MESIL_RS05725	COG1796	DNA polymerase
MESIL_RS05725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MESIL_RS05730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MESIL_RS05740	COG0508	dehydrogenase complex catalyzes the overall conversion of
MESIL_RS05745	COG0022	dehydrogenase e1 component
MESIL_RS05750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MESIL_RS05755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MESIL_RS05760	COG2514	catechol 2,3-dioxygenase activity
MESIL_RS05820	COG0789	Transcriptional regulator
MESIL_RS05840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MESIL_RS05875	COG0793	Belongs to the peptidase S41A family
MESIL_RS05880	COG1694	Mazg nucleotide pyrophosphohydrolase
MESIL_RS05885	COG1803	Methylglyoxal synthase
MESIL_RS05900	COG1193	negative regulation of DNA recombination
MESIL_RS05905	COG0366	Alpha amylase catalytic
MESIL_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS05955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MESIL_RS05960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MESIL_RS05975	COG0582	viral genome integration into host DNA
MESIL_RS06025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MESIL_RS06225	COG1857	crispr-associated protein
MESIL_RS06265	COG0135	phosphoribosylanthranilate isomerase activity
MESIL_RS06270	COG1216	Glycosyl transferase, family 2
MESIL_RS06275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MESIL_RS06280	COG0248	Ppx GppA phosphatase
MESIL_RS06285	COG2062	phosphohistidine phosphatase, SixA
MESIL_RS06300	COG1024	Enoyl-CoA hydratase
MESIL_RS06305	COG3119	arylsulfatase activity
MESIL_RS06310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MESIL_RS06325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MESIL_RS06330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MESIL_RS06335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MESIL_RS06340	COG0427	acetyl-CoA hydrolase
MESIL_RS06380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MESIL_RS06385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MESIL_RS06390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MESIL_RS06395	COG0805	protein transport
MESIL_RS06400	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MESIL_RS06400	COG1605	Chorismate mutase
MESIL_RS06405	COG1007	ATP synthesis coupled electron transport
MESIL_RS06410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MESIL_RS06415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MESIL_RS06420	COG0713	ATP synthesis coupled electron transport
MESIL_RS06425	COG0839	Belongs to the complex I subunit 6 family
MESIL_RS06430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MESIL_RS06435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MESIL_RS06440	COG1034	ATP synthesis coupled electron transport
MESIL_RS06445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MESIL_RS06450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MESIL_RS06455	COG0649	NAD binding
MESIL_RS06460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MESIL_RS06465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MESIL_RS06470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MESIL_RS06475	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MESIL_RS06520	COG0347	Belongs to the P(II) protein family
MESIL_RS06530	COG0473	3-isopropylmalate dehydrogenase activity
MESIL_RS06535	COG0861	Integral membrane protein TerC family
MESIL_RS06540	COG0861	Integral membrane protein TerC family
MESIL_RS06545	COG0861	Integral membrane protein TerC family
MESIL_RS06555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MESIL_RS06555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MESIL_RS06605	COG1597	lipid kinase activity
MESIL_RS06625	COG0628	permease
MESIL_RS06640	COG0194	GDP metabolic process
MESIL_RS06650	COG1438	arginine binding
MESIL_RS06660	COG2095	MarC family integral membrane protein
MESIL_RS06670	COG0497	DNA recombination
MESIL_RS06680	COG0736	holo-[acyl-carrier-protein] synthase activity
MESIL_RS06685	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MESIL_RS06685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MESIL_RS06690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MESIL_RS06695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MESIL_RS06700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MESIL_RS06705	COG1450	Type ii and iii secretion system protein
MESIL_RS06730	COG0473	3-isopropylmalate dehydrogenase activity
MESIL_RS06775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MESIL_RS06810	COG0793	Belongs to the peptidase S41A family
MESIL_RS06820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MESIL_RS06835	COG0681	Belongs to the peptidase S26 family
MESIL_RS06845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MESIL_RS06850	COG0460	homoserine dehydrogenase
MESIL_RS06885	COG0747	negative chemotaxis
MESIL_RS06890	COG0601	transmembrane transport
MESIL_RS06895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS06900	COG0444	Belongs to the ABC transporter superfamily
MESIL_RS06915	COG1506	peptidase
MESIL_RS06915	COG0823	Involved in the tonB-independent uptake of proteins
MESIL_RS06915	COG4946	Tricorn protease homolog
MESIL_RS06940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MESIL_RS06945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MESIL_RS06965	COG2815	serine threonine protein kinase
MESIL_RS06965	COG0515	serine threonine protein kinase
MESIL_RS06970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MESIL_RS06975	COG1233	COG1233 Phytoene dehydrogenase and related
MESIL_RS06980	COG0415	Belongs to the DNA photolyase family
MESIL_RS06985	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MESIL_RS07005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MESIL_RS07010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MESIL_RS07015	COG4558	Periplasmic binding protein
MESIL_RS07040	COG2205	protein histidine kinase activity
MESIL_RS07065	COG0210	DNA helicase
MESIL_RS07105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MESIL_RS07125	COG0366	Alpha amylase catalytic
MESIL_RS07150	COG0842	Transport permease protein
MESIL_RS07150	COG1129	ABC transporter
MESIL_RS07155	COG0793	Belongs to the peptidase S41A family
MESIL_RS07160	COG2884	Cell division ATP-binding protein ftsE
MESIL_RS07165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MESIL_RS07190	COG0247	lactate metabolic process
MESIL_RS07195	COG0277	FAD linked oxidase domain protein
MESIL_RS07200	COG0277	FAD linked oxidase domain protein
MESIL_RS07210	COG0714	Associated with various cellular activities
MESIL_RS07220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MESIL_RS07225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MESIL_RS07230	COG2009	succinate dehydrogenase
MESIL_RS07240	COG1053	succinate dehydrogenase
MESIL_RS07245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MESIL_RS07260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MESIL_RS07265	COG0515	serine threonine protein kinase
MESIL_RS07270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MESIL_RS07285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MESIL_RS07295	COG1269	ATP hydrolysis coupled proton transport
MESIL_RS07305	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
MESIL_RS07310	COG1527	subunit (C
MESIL_RS07315	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MESIL_RS07320	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MESIL_RS07325	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MESIL_RS07330	COG1394	ATPase activity, coupled to movement of substances
MESIL_RS07345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MESIL_RS07355	COG0612	Peptidase, M16
MESIL_RS07360	COG0612	Peptidase, M16
MESIL_RS07375	COG0697	spore germination
MESIL_RS07380	COG1250	3-hydroxyacyl-CoA dehydrogenase
MESIL_RS07400	COG1960	acyl-CoA dehydrogenase activity
MESIL_RS07405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MESIL_RS07405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MESIL_RS07415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MESIL_RS07420	COG0195	Participates in both transcription termination and antitermination
MESIL_RS07425	COG0779	Required for maturation of 30S ribosomal subunits
MESIL_RS07430	COG2207	Transcriptional regulator
MESIL_RS07435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MESIL_RS07455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MESIL_RS07465	COG0275	rRNA processing
MESIL_RS07470	COG1562	ergosterol biosynthetic process
MESIL_RS07495	COG0463	Glycosyl transferase, family 2
MESIL_RS07500	COG1233	COG1233 Phytoene dehydrogenase and related
MESIL_RS07510	COG1607	acyl-coa hydrolase
MESIL_RS07515	COG1304	FMN binding
MESIL_RS07550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MESIL_RS07555	COG0142	geranyltranstransferase activity
MESIL_RS07560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MESIL_RS07565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MESIL_RS07580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MESIL_RS07585	COG0322	excinuclease ABC activity
MESIL_RS07600	COG1881	PFAM PEBP family protein
MESIL_RS07605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MESIL_RS07620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MESIL_RS07635	COG2423	ornithine cyclodeaminase activity
MESIL_RS07640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MESIL_RS07645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MESIL_RS07655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MESIL_RS07660	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MESIL_RS07665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MESIL_RS07680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MESIL_RS07685	COG0488	(ABC) transporter
MESIL_RS07700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MESIL_RS07715	COG0483	inositol monophosphate 1-phosphatase activity
MESIL_RS07720	COG2890	protein-(glutamine-N5) methyltransferase activity
MESIL_RS07725	COG1847	R3H domain protein
MESIL_RS07730	COG0706	membrane insertase activity
MESIL_RS07735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MESIL_RS07790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MESIL_RS07790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MESIL_RS07795	COG1733	regulation of RNA biosynthetic process
MESIL_RS07800	COG2894	cell division
MESIL_RS07805	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MESIL_RS07810	COG0772	Belongs to the SEDS family
MESIL_RS07820	COG3842	ATPase activity
MESIL_RS07855	COG2010	Cytochrome c
MESIL_RS07865	COG2010	Cytochrome c
MESIL_RS07875	COG1177	transmembrane transport
MESIL_RS07880	COG1176	ABC-type spermidine putrescine transport system, permease component I
MESIL_RS07885	COG3842	ATPase activity
MESIL_RS07900	COG1316	TRANSCRIPTIONal
MESIL_RS07970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MESIL_RS07980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MESIL_RS07985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MESIL_RS07995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MESIL_RS08005	COG1104	cysteine desulfurase activity
MESIL_RS08010	COG0318	PFAM AMP-dependent synthetase and ligase
MESIL_RS08030	COG1473	amidohydrolase
MESIL_RS08040	COG0129	dihydroxy-acid dehydratase activity
MESIL_RS08050	COG0473	3-isopropylmalate dehydrogenase activity
MESIL_RS08055	COG0066	3-isopropylmalate dehydratase activity
MESIL_RS08065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MESIL_RS08085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MESIL_RS08090	COG0180	Tryptophanyl-tRNA synthetase
MESIL_RS08105	COG0183	Belongs to the thiolase family
MESIL_RS08115	COG0287	Prephenate dehydrogenase
MESIL_RS08120	COG2050	protein possibly involved in aromatic compounds catabolism
MESIL_RS08135	COG0585	pseudouridine synthase activity
MESIL_RS08140	COG0590	tRNA wobble adenosine to inosine editing
MESIL_RS08140	COG0037	tRNA processing
MESIL_RS08155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MESIL_RS08160	COG0372	Belongs to the citrate synthase family
MESIL_RS08165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MESIL_RS08175	COG1131	(ABC) transporter
MESIL_RS08190	COG2217	Heavy metal translocating P-type atpase
MESIL_RS08195	COG0640	Transcriptional regulator
MESIL_RS08230	COG1228	amidohydrolase
MESIL_RS08235	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MESIL_RS08240	COG2188	Transcriptional regulator
MESIL_RS08245	COG2986	histidine ammonia-lyase
MESIL_RS08255	COG0714	Associated with various cellular activities
MESIL_RS08270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MESIL_RS08275	COG0653	protein targeting
MESIL_RS08280	COG1408	metallophosphoesterase
MESIL_RS08285	COG0217	transcriptional regulatory protein
MESIL_RS08295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MESIL_RS08310	COG0196	riboflavin kinase activity
MESIL_RS08315	COG0494	nUDIX hydrolase
MESIL_RS08320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MESIL_RS08325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MESIL_RS08335	COG0515	serine threonine protein kinase
MESIL_RS08335	COG2815	serine threonine protein kinase
MESIL_RS08340	COG1752	Esterase of the alpha-beta hydrolase superfamily
MESIL_RS08350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MESIL_RS08355	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MESIL_RS08390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MESIL_RS08395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MESIL_RS08410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MESIL_RS08415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MESIL_RS08420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MESIL_RS08425	COG0772	Belongs to the SEDS family
MESIL_RS08430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MESIL_RS08435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MESIL_RS08460	COG0275	rRNA processing
MESIL_RS08465	COG2001	Belongs to the MraZ family
MESIL_RS08485	COG0538	isocitrate dehydrogenase activity
MESIL_RS08530	COG2137	regulation of response to DNA damage stimulus
MESIL_RS08550	COG0215	cysteine-tRNA ligase activity
MESIL_RS08555	COG2738	Putative neutral zinc metallopeptidase
MESIL_RS08560	COG2359	stage V sporulation protein S
MESIL_RS08570	COG0067	glutamate synthase
MESIL_RS08570	COG0070	glutamate synthase
MESIL_RS08570	COG0069	glutamate synthase activity
MESIL_RS08580	COG1011	Hydrolase
MESIL_RS08585	COG0632	four-way junction helicase activity
MESIL_RS08590	COG1024	Enoyl-CoA hydratase
MESIL_RS08600	COG1024	Enoyl-CoA hydratase
MESIL_RS08615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MESIL_RS08620	COG0039	L-malate dehydrogenase activity
MESIL_RS08630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MESIL_RS08655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MESIL_RS08655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MESIL_RS08670	COG1331	Highly conserved protein containing a thioredoxin domain
MESIL_RS08675	COG1692	metallophosphoesterase
MESIL_RS08685	COG0405	Gamma-glutamyltransferase
MESIL_RS08690	COG3360	Dodecin
MESIL_RS08710	COG0504	CTP synthase activity
MESIL_RS08720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MESIL_RS08720	COG2199	diguanylate cyclase activity
MESIL_RS08785	COG0582	viral genome integration into host DNA
MESIL_RS08950	COG3195	allantoin biosynthetic process
MESIL_RS08950	COG3648	Uricase
MESIL_RS08965	COG2351	hydroxyisourate hydrolase activity
MESIL_RS08975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MESIL_RS08985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MESIL_RS08990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MESIL_RS08995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MESIL_RS09005	COG3845	ABC transporter
MESIL_RS09010	COG4603	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS09015	COG1079	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS09025	COG0402	S-adenosylhomocysteine deaminase activity
MESIL_RS09030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MESIL_RS09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
MESIL_RS09040	COG1024	Enoyl-CoA hydratase
MESIL_RS09065	COG0183	Belongs to the thiolase family
MESIL_RS09085	COG1960	acyl-CoA dehydrogenase activity
MESIL_RS09095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MESIL_RS09110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MESIL_RS09115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MESIL_RS09125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MESIL_RS09125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MESIL_RS09150	COG2719	SpoVR family
MESIL_RS09160	COG2766	serine protein kinase
MESIL_RS09180	COG0402	S-adenosylhomocysteine deaminase activity
MESIL_RS09190	COG4948	Mandelate Racemase Muconate Lactonizing
MESIL_RS09195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MESIL_RS09200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MESIL_RS09205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MESIL_RS09210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MESIL_RS09220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MESIL_RS09220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MESIL_RS09225	COG0726	polysaccharide deacetylase
MESIL_RS09235	COG1216	Glycosyl transferase, family 2
MESIL_RS09245	COG0133	tryptophan synthase activity
MESIL_RS09250	COG0159	tryptophan synthase activity
MESIL_RS09255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MESIL_RS09260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MESIL_RS09285	COG0643	Histidine kinase
MESIL_RS09285	COG2198	Histidine kinase
MESIL_RS09300	COG2030	dehydratase
MESIL_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
MESIL_RS09335	COG0544	peptidyl-prolyl cis-trans isomerase activity
MESIL_RS09340	COG0740	serine-type endopeptidase activity
MESIL_RS09345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MESIL_RS09355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MESIL_RS09360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MESIL_RS09370	COG1674	ftsk spoiiie
MESIL_RS09415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MESIL_RS09420	COG2703	oxygen carrier activity
MESIL_RS09435	COG0288	reversible hydration of carbon dioxide
MESIL_RS09445	COG0167	dihydroorotate dehydrogenase activity
MESIL_RS09460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MESIL_RS09470	COG0420	3'-5' exonuclease activity
MESIL_RS09475	COG0419	ATPase involved in DNA repair
MESIL_RS09480	COG0728	peptidoglycan biosynthetic process
MESIL_RS09485	COG0017	Asparaginyl-tRNA synthetase
MESIL_RS09490	COG0084	hydrolase, TatD family'
MESIL_RS09500	COG1755	Isoprenylcysteine carboxyl methyltransferase
MESIL_RS09510	COG0778	Nitroreductase
MESIL_RS09620	COG4383	Mu-like prophage protein gp29
MESIL_RS09730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MESIL_RS09750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MESIL_RS09755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MESIL_RS09770	COG0508	dehydrogenase complex catalyzes the overall conversion of
MESIL_RS09775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MESIL_RS09780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MESIL_RS09785	COG0646	methionine synthase
MESIL_RS09785	COG1410	methionine synthase
MESIL_RS09790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MESIL_RS09790	COG1796	DNA polymerase
MESIL_RS09800	COG0456	acetyltransferase
MESIL_RS09805	COG1283	sodium-dependent phosphate transmembrane transporter activity
MESIL_RS09810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MESIL_RS09810	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MESIL_RS09815	COG1131	(ABC) transporter
MESIL_RS09830	COG1131	(ABC) transporter
MESIL_RS09840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MESIL_RS09850	COG0750	zinc metalloprotease
MESIL_RS09855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MESIL_RS09860	COG0575	Belongs to the CDS family
MESIL_RS09865	COG0233	cytoplasmic translational termination
MESIL_RS09870	COG0528	UMP kinase activity
MESIL_RS09875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MESIL_RS09880	COG0052	Belongs to the universal ribosomal protein uS2 family
MESIL_RS09895	COG1597	lipid kinase activity
MESIL_RS09920	COG0438	transferase activity, transferring glycosyl groups
MESIL_RS09930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MESIL_RS09955	COG3005	denitrification pathway
MESIL_RS09960	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MESIL_RS09965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MESIL_RS09985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MESIL_RS09995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MESIL_RS10000	COG2873	o-acetylhomoserine
MESIL_RS10020	COG1840	ABC-type Fe3 transport system, periplasmic component
MESIL_RS10030	COG3842	ATPase activity
MESIL_RS10050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MESIL_RS10055	COG2264	protein methyltransferase activity
MESIL_RS10060	COG0803	Belongs to the bacterial solute-binding protein 9 family
MESIL_RS10075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MESIL_RS10080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MESIL_RS10085	COG0509	glycine decarboxylation via glycine cleavage system
MESIL_RS10090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MESIL_RS10095	COG1100	Small GTP-binding protein
MESIL_RS10115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MESIL_RS10135	COG0366	Alpha amylase catalytic
MESIL_RS10140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MESIL_RS10145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MESIL_RS10150	COG1185	polyribonucleotide nucleotidyltransferase activity
MESIL_RS10155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MESIL_RS10160	COG2814	Major facilitator Superfamily
MESIL_RS10165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MESIL_RS10170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MESIL_RS10195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MESIL_RS10200	COG0511	ligase activity, forming carbon-carbon bonds
MESIL_RS10205	COG0439	Biotin carboxylase
MESIL_RS10210	COG0494	nUDIX hydrolase
MESIL_RS10215	COG0517	IMP dehydrogenase activity
MESIL_RS10215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MESIL_RS10215	COG0617	tRNA 3'-terminal CCA addition
MESIL_RS10225	COG1994	Peptidase M50
MESIL_RS10230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MESIL_RS10235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MESIL_RS10240	COG0006	proline dipeptidase activity
MESIL_RS10245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MESIL_RS10250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MESIL_RS10255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MESIL_RS10265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MESIL_RS10270	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MESIL_RS10275	COG0017	Asparaginyl-tRNA synthetase
MESIL_RS10290	COG0560	Phosphoserine phosphatase
MESIL_RS10295	COG0384	phenazine biosynthesis protein PhzF
MESIL_RS10305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MESIL_RS10320	COG1196	nuclear chromosome segregation
MESIL_RS10335	COG0124	histidyl-tRNA synthetase
MESIL_RS10340	COG1175	transmembrane transport
MESIL_RS10345	COG0395	ABC-type sugar transport system, permease component
MESIL_RS10360	COG0126	phosphoglycerate kinase activity
MESIL_RS10365	COG0149	triose-phosphate isomerase activity
MESIL_RS10375	COG0071	Belongs to the small heat shock protein (HSP20) family
MESIL_RS10385	COG1309	transcriptional regulator
MESIL_RS10415	COG1024	Enoyl-CoA hydratase
MESIL_RS10420	COG0813	purine-nucleoside phosphorylase activity
MESIL_RS10425	COG1136	(ABC) transporter
MESIL_RS10430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MESIL_RS10435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MESIL_RS10440	COG2045	Belongs to the ComB family
MESIL_RS10450	COG0789	Transcriptional regulator
MESIL_RS10465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MESIL_RS10470	COG0742	ribosomal rna small subunit methyltransferase
MESIL_RS10505	COG1744	ABC transporter substrate-binding protein PnrA-like
MESIL_RS10510	COG3845	ABC transporter
MESIL_RS10520	COG0077	Prephenate dehydratase
MESIL_RS10520	COG1605	Chorismate mutase
MESIL_RS10525	COG0745	RESPONSE REGULATOR receiver
MESIL_RS10550	COG0517	IMP dehydrogenase activity
MESIL_RS10565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MESIL_RS10580	COG0402	S-adenosylhomocysteine deaminase activity
MESIL_RS10585	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MESIL_RS10590	COG1280	lysine exporter protein (LysE YggA)
MESIL_RS10600	COG0167	dihydroorotate dehydrogenase activity
MESIL_RS10600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MESIL_RS10605	COG0493	'glutamate synthase
MESIL_RS10610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MESIL_RS10635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MESIL_RS10655	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
MESIL_RS10665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MESIL_RS10700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MESIL_RS10705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MESIL_RS10710	COG0243	molybdopterin cofactor binding
MESIL_RS10715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MESIL_RS10730	COG0277	FAD linked oxidase domain protein
MESIL_RS10745	COG1459	type II secretion system
MESIL_RS10750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MESIL_RS10760	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MESIL_RS10765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MESIL_RS10770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MESIL_RS10775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MESIL_RS10785	COG0440	acetolactate synthase activity
MESIL_RS10790	COG0028	Belongs to the TPP enzyme family
MESIL_RS10800	COG0492	ferredoxin-NADP+ reductase activity
MESIL_RS10805	COG0861	Integral membrane protein TerC family
MESIL_RS10820	COG0114	fumarate hydratase activity
MESIL_RS10825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MESIL_RS10840	COG0134	indole-3-glycerol-phosphate synthase activity
MESIL_RS10845	COG1752	Esterase of the alpha-beta hydrolase superfamily
MESIL_RS10860	COG2358	TRAP transporter, solute receptor (TAXI family
MESIL_RS10870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MESIL_RS10875	COG0107	imidazoleglycerol-phosphate synthase activity
MESIL_RS10880	COG0140	phosphoribosyl-ATP diphosphatase activity
MESIL_RS10880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MESIL_RS10885	COG1494	fructose-1,6-bisphosphatase
MESIL_RS10895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MESIL_RS10900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MESIL_RS10910	COG4558	Periplasmic binding protein
MESIL_RS10930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MESIL_RS10935	COG0423	glycine-tRNA ligase activity
MESIL_RS10940	COG0542	response to heat
MESIL_RS10945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MESIL_RS10950	COG4956	integral membrane protein (PIN domain superfamily)
MESIL_RS10965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MESIL_RS10980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MESIL_RS10985	COG0519	Catalyzes the synthesis of GMP from XMP
MESIL_RS10985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MESIL_RS11005	COG1573	uracil-dna glycosylase
MESIL_RS11015	COG1012	belongs to the aldehyde dehydrogenase family
MESIL_RS11020	COG0138	bifunctional purine biosynthesis protein purh
MESIL_RS11060	COG1970	mechanosensitive ion channel activity
MESIL_RS11070	COG3842	ATPase activity
MESIL_RS11075	COG0572	uridine kinase
MESIL_RS11095	COG2176	DNA-directed DNA polymerase activity
MESIL_RS11100	COG0154	amidase activity
MESIL_RS11105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MESIL_RS11115	COG1435	thymidine kinase activity
MESIL_RS11120	COG0254	rRNA binding
MESIL_RS11145	COG0237	dephospho-CoA kinase activity
MESIL_RS11150	COG0617	tRNA 3'-terminal CCA addition
MESIL_RS11165	COG0557	exoribonuclease II activity
MESIL_RS11180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MESIL_RS11185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MESIL_RS11190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MESIL_RS11190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MESIL_RS11200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MESIL_RS11205	COG1030	water channel activity
MESIL_RS11210	COG4864	UPF0365 protein
MESIL_RS11220	COG1702	phosphate starvation-inducible protein PhoH
MESIL_RS11225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MESIL_RS11230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MESIL_RS11235	COG1253	flavin adenine dinucleotide binding
MESIL_RS11250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MESIL_RS11260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MESIL_RS11265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MESIL_RS11305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MESIL_RS11320	COG0477	Major facilitator Superfamily
MESIL_RS11325	COG1205	dead DEAH box helicase
MESIL_RS11325	COG1111	helicase
MESIL_RS11330	COG3263	regulation of cellular component size
MESIL_RS11340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MESIL_RS11345	COG4651	solute:proton antiporter activity
MESIL_RS11345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MESIL_RS11355	COG1254	Belongs to the acylphosphatase family
MESIL_RS11360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MESIL_RS11365	COG0546	phosphoglycolate phosphatase activity
MESIL_RS11385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MESIL_RS11410	COG0358	DNA primase activity
MESIL_RS11415	COG1959	2 iron, 2 sulfur cluster binding
MESIL_RS11420	COG2897	thiosulfate sulfurtransferase activity
MESIL_RS11430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MESIL_RS11440	COG0335	large ribosomal subunit rRNA binding
MESIL_RS11445	COG0336	Belongs to the RNA methyltransferase TrmD family
MESIL_RS11450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MESIL_RS11455	COG1837	Belongs to the UPF0109 family
MESIL_RS11460	COG0228	four-way junction DNA binding
MESIL_RS11480	COG2239	Acts as a magnesium transporter
MESIL_RS11540	COG2813	Specifically methylates the guanine in position
MESIL_RS11550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MESIL_RS11565	COG0488	(ABC) transporter
MESIL_RS11575	COG0488	(ABC) transporter
MESIL_RS11595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MESIL_RS11600	COG2508	Transcriptional regulator
MESIL_RS11605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MESIL_RS11620	COG1012	belongs to the aldehyde dehydrogenase family
MESIL_RS11625	COG2368	4-hydroxyphenylacetate
MESIL_RS11630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MESIL_RS11640	COG1250	3-hydroxyacyl-CoA dehydrogenase
MESIL_RS11665	COG2050	protein possibly involved in aromatic compounds catabolism
MESIL_RS11670	COG0183	Belongs to the thiolase family
MESIL_RS11675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MESIL_RS11685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MESIL_RS11695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MESIL_RS11700	COG0318	PFAM AMP-dependent synthetase and ligase
MESIL_RS11705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MESIL_RS11710	COG2030	dehydratase
MESIL_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS11750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MESIL_RS11770	COG1845	cytochrome c oxidase, subunit III
MESIL_RS11780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MESIL_RS11785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MESIL_RS11800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MESIL_RS11815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MESIL_RS11830	COG2311	Membrane
MESIL_RS11835	COG0505	Belongs to the CarA family
MESIL_RS11850	COG0165	Argininosuccinate lyase
MESIL_RS11860	COG0137	argininosuccinate synthase activity
MESIL_RS11880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MESIL_RS11910	COG0481	GTPase activity
MESIL_RS11920	COG2197	response regulator
MESIL_RS11925	COG3870	Protein conserved in bacteria
MESIL_RS11935	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MESIL_RS11940	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MESIL_RS11950	COG1175	transmembrane transport
MESIL_RS11960	COG1940	carbohydrate kinase activity
MESIL_RS11965	COG1490	D-aminoacyl-tRNA deacylase activity
MESIL_RS11970	COG1307	EDD domain protein, DegV family
MESIL_RS11975	COG1307	EDD domain protein, DegV family
MESIL_RS11980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MESIL_RS12000	COG1349	DNA-binding transcription factor activity
MESIL_RS12005	COG1653	transport
MESIL_RS12010	COG1175	transmembrane transport
MESIL_RS12015	COG0395	ABC-type sugar transport system, permease component
MESIL_RS12025	COG1085	galactose-1-phosphate uridylyltransferase
MESIL_RS12035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MESIL_RS12045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MESIL_RS12055	COG3842	ATPase activity
MESIL_RS12060	COG1176	ABC-type spermidine putrescine transport system, permease component I
MESIL_RS12065	COG1177	transmembrane transport
MESIL_RS12080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MESIL_RS12120	COG1012	belongs to the aldehyde dehydrogenase family
MESIL_RS12125	COG1177	transmembrane transport
MESIL_RS12130	COG1176	ABC-type spermidine putrescine transport system, permease component I
MESIL_RS12135	COG3842	ATPase activity
MESIL_RS12140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MESIL_RS12145	COG0583	DNA-binding transcription factor activity
MESIL_RS12165	COG2151	metal-sulfur cluster biosynthetic enzyme
MESIL_RS12170	COG0823	Involved in the tonB-independent uptake of proteins
MESIL_RS12175	COG0860	N-Acetylmuramoyl-L-alanine amidase
MESIL_RS12185	COG0247	lactate metabolic process
MESIL_RS12185	COG2181	nitrate reductase activity
MESIL_RS12195	COG1672	PFAM Archaeal ATPase
MESIL_RS12195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MESIL_RS12205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MESIL_RS12240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MESIL_RS12245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MESIL_RS12305	COG0018	arginyl-trna synthetase
MESIL_RS12310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MESIL_RS12315	COG1428	Deoxynucleoside kinase
MESIL_RS12320	COG1428	Deoxynucleoside kinase
MESIL_RS12345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MESIL_RS12350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MESIL_RS12355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MESIL_RS12365	COG0165	Argininosuccinate lyase
MESIL_RS12370	COG0395	ABC-type sugar transport system, permease component
MESIL_RS12375	COG1175	transmembrane transport
MESIL_RS12380	COG2182	Extracellular solute-binding protein
MESIL_RS12395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MESIL_RS12400	COG0739	heme binding
MESIL_RS12405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MESIL_RS12420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MESIL_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS12440	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MESIL_RS12445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MESIL_RS12455	COG1324	tolerance protein
MESIL_RS12460	COG0598	Magnesium transport protein CorA
MESIL_RS12465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MESIL_RS12475	COG0492	ferredoxin-NADP+ reductase activity
MESIL_RS12480	COG0737	Belongs to the 5'-nucleotidase family
MESIL_RS12495	COG0174	glutamine synthetase
MESIL_RS12530	COG0747	negative chemotaxis
MESIL_RS12540	COG0601	transmembrane transport
MESIL_RS12545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS12555	COG0285	dihydrofolate synthase activity
MESIL_RS12560	COG0521	Mo-molybdopterin cofactor biosynthetic process
MESIL_RS12570	COG1132	(ABC) transporter
MESIL_RS12575	COG1132	(ABC) transporter
MESIL_RS12595	COG2197	response regulator
MESIL_RS12620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MESIL_RS12625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MESIL_RS12630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MESIL_RS12650	COG1960	acyl-CoA dehydrogenase activity
MESIL_RS12665	COG0312	modulator of DNA gyrase
MESIL_RS12680	COG2318	DinB family
MESIL_RS12685	COG0604	alcohol dehydrogenase
MESIL_RS12685	COG3321	synthase
MESIL_RS12690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS12695	COG0601	transmembrane transport
MESIL_RS12700	COG0747	negative chemotaxis
MESIL_RS12715	COG1994	Peptidase M50
MESIL_RS12715	COG0517	IMP dehydrogenase activity
MESIL_RS12745	COG0730	response to heat
MESIL_RS12750	COG3341	Caulimovirus viroplasmin
MESIL_RS12750	COG0328	RNA-DNA hybrid ribonuclease activity
MESIL_RS12760	COG0489	protein tyrosine kinase activity
MESIL_RS12785	COG1051	belongs to the nudix hydrolase family
MESIL_RS12790	COG0525	valine-tRNA ligase activity
MESIL_RS12810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MESIL_RS12820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MESIL_RS12825	COG0010	Belongs to the arginase family
MESIL_RS12835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MESIL_RS12840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MESIL_RS12845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MESIL_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS12855	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS12860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MESIL_RS12865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MESIL_RS12870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MESIL_RS12875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MESIL_RS12880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MESIL_RS12890	COG0671	phosphoesterase, PA-phosphatase related
MESIL_RS12910	COG0564	pseudouridine synthase activity
MESIL_RS12915	COG1418	mRNA catabolic process
MESIL_RS12920	COG2255	four-way junction helicase activity
MESIL_RS12930	COG3835	regulator
MESIL_RS12965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MESIL_RS12970	COG2188	Transcriptional regulator
MESIL_RS12975	COG0747	negative chemotaxis
MESIL_RS12980	COG0601	transmembrane transport
MESIL_RS12985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS12990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MESIL_RS12995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MESIL_RS13000	COG0747	negative chemotaxis
MESIL_RS13005	COG0601	transmembrane transport
MESIL_RS13010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS13020	COG3876	Protein conserved in bacteria
MESIL_RS13025	COG2385	sporulation resulting in formation of a cellular spore
MESIL_RS13040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MESIL_RS13050	COG0424	maF-like protein
MESIL_RS13065	COG0768	penicillin binding
MESIL_RS13085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MESIL_RS13100	COG4712	double-strand break repair protein
MESIL_RS13115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MESIL_RS13120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MESIL_RS13125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MESIL_RS13135	COG0131	Imidazoleglycerol-phosphate dehydratase
MESIL_RS13140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MESIL_RS13160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MESIL_RS13170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MESIL_RS13175	COG2326	polyphosphate kinase activity
MESIL_RS13210	COG1054	Belongs to the UPF0176 family
MESIL_RS13215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MESIL_RS13220	COG1937	Protein conserved in bacteria
MESIL_RS13225	COG1272	protein, Hemolysin III
MESIL_RS13235	COG5002	protein histidine kinase activity
MESIL_RS13280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MESIL_RS13305	COG0673	inositol 2-dehydrogenase activity
MESIL_RS13315	COG1175	transmembrane transport
MESIL_RS13325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MESIL_RS13365	COG0789	Transcriptional regulator
MESIL_RS13420	COG0222	ribosome binding
MESIL_RS13425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MESIL_RS13445	COG3483	tryptophan 2,3-dioxygenase activity
MESIL_RS13470	COG0081	regulation of translation
MESIL_RS13480	COG0250	Participates in transcription elongation, termination and antitermination
MESIL_RS13485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MESIL_RS13490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MESIL_RS13525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MESIL_RS13540	COG2068	MobA-Related Protein
MESIL_RS13560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MESIL_RS13570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MESIL_RS13575	COG0746	molybdenum cofactor guanylyltransferase activity
MESIL_RS13580	COG4585	Histidine kinase
MESIL_RS13595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MESIL_RS13630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MESIL_RS13635	COG0284	orotidine-5'-phosphate decarboxylase activity
MESIL_RS13650	COG1764	response to oxidative stress
MESIL_RS13655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MESIL_RS13675	COG3487	Iron-regulated protein
MESIL_RS13685	COG1178	ABC-type Fe3 transport system permease component
MESIL_RS13695	COG3548	integral membrane protein
MESIL_RS13700	COG0101	tRNA pseudouridine synthase activity
MESIL_RS13715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MESIL_RS13720	COG0601	transmembrane transport
MESIL_RS13725	COG0747	negative chemotaxis
MESIL_RS13735	COG0316	Belongs to the HesB IscA family
MESIL_RS13745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MESIL_RS13765	COG0438	transferase activity, transferring glycosyl groups
MESIL_RS13785	COG1216	Glycosyl transferase, family 2
MESIL_RS13795	COG2244	polysaccharide biosynthetic process
MESIL_RS13825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MESIL_RS13860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MESIL_RS13870	COG1914	H( )-stimulated, divalent metal cation uptake system
MESIL_RS13910	COG0589	response to stress
MESIL_RS13915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MESIL_RS13920	COG1993	acr, cog1993
MESIL_RS13935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MESIL_RS13940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MESIL_RS13945	COG2855	membrane
MESIL_RS13955	COG1595	DNA-templated transcription, initiation
MESIL_RS13990	COG2010	Cytochrome c
MESIL_RS14000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MESIL_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS14020	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MESIL_RS14020	COG3408	Glycogen debranching enzyme
MESIL_RS14025	COG0395	ABC-type sugar transport system, permease component
MESIL_RS14030	COG1175	transmembrane transport
MESIL_RS14040	COG1609	Transcriptional regulator
MESIL_RS14050	COG2823	Periplasmic or secreted lipoprotein
MESIL_RS14050	COG1652	LysM domain
MESIL_RS14095	COG0745	RESPONSE REGULATOR receiver
MESIL_RS14105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MESIL_RS14110	COG0765	amino acid transport
MESIL_RS14120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MESIL_RS14125	COG0438	transferase activity, transferring glycosyl groups
MESIL_RS14130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MESIL_RS14135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MESIL_RS14145	COG0477	Major facilitator Superfamily
MESIL_RS14160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MESIL_RS14170	COG0259	pyridoxamine-phosphate oxidase activity
MESIL_RS14175	COG1131	(ABC) transporter
MESIL_RS14195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MESIL_RS14215	COG0477	Major facilitator Superfamily
MESIL_RS14235	COG2385	sporulation resulting in formation of a cellular spore
MESIL_RS14235	COG2247	cell wall binding repeat
MESIL_RS14240	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MESIL_RS14245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MESIL_RS14250	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MESIL_RS14280	COG0629	single-stranded DNA binding
MESIL_RS14300	COG1643	Atp-dependent helicase
MESIL_RS14310	COG3548	integral membrane protein
MESIL_RS14320	COG2197	response regulator
MESIL_RS14330	COG1349	DNA-binding transcription factor activity
MESIL_RS14335	COG1129	ABC transporter
MESIL_RS14340	COG1172	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS14345	COG1172	Belongs to the binding-protein-dependent transport system permease family
MESIL_RS14350	COG1879	ABC-type sugar transport system periplasmic component
MESIL_RS14360	COG4952	isomerase
MESIL_RS14365	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS14365	COG3347	Dehydrogenase
MESIL_RS14370	COG1070	Carbohydrate kinase
MESIL_RS14435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MESIL_RS14440	COG0604	alcohol dehydrogenase
MESIL_RS14465	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MESIL_RS14475	COG0203	ribosomal protein L17
MESIL_RS14480	COG0202	RNA polymerase activity
MESIL_RS14485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MESIL_RS14490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MESIL_RS14495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MESIL_RS14505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MESIL_RS14515	COG0563	adenylate kinase activity
MESIL_RS14520	COG0201	protein transport
MESIL_RS14545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MESIL_RS14550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MESIL_RS14580	COG0255	Belongs to the universal ribosomal protein uL29 family
MESIL_RS14585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MESIL_RS14590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MESIL_RS14600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MESIL_RS14605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MESIL_RS14610	COG0089	rRNA binding
MESIL_RS14615	COG0088	Forms part of the polypeptide exit tunnel
MESIL_RS14625	COG0051	transcription antitermination factor activity, RNA binding
MESIL_RS14640	COG0049	tRNA binding
MESIL_RS14690	COG3956	TIGRFAM MazG family protein
MESIL_RS14700	COG0693	protein deglycase activity
MESIL_RS14725	COG1396	sequence-specific DNA binding
MESIL_RS14735	COG2856	Zn peptidase
MESIL_RS14740	COG2816	NAD+ diphosphatase activity
MESIL_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
MESIL_RS14750	COG0302	gtp cyclohydrolase
MESIL_RS14755	COG0463	Glycosyl transferase, family 2
MESIL_RS14765	COG0438	transferase activity, transferring glycosyl groups
MESIL_RS14795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MESIL_RS14815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MESIL_RS14875	COG0156	8-amino-7-oxononanoate synthase activity
MESIL_RS14880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MESIL_RS14965	COG1940	carbohydrate kinase activity
MESIL_RS14975	COG0745	RESPONSE REGULATOR receiver
MESIL_RS14980	COG1404	Belongs to the peptidase S8 family
MESIL_RS14995	COG0745	RESPONSE REGULATOR receiver
MESIL_RS15005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MESIL_RS15010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MESIL_RS15015	COG0181	hydroxymethylbilane synthase activity
MESIL_RS15025	COG0113	porphobilinogen synthase activity
MESIL_RS15030	COG5002	protein histidine kinase activity
MESIL_RS15035	COG0745	RESPONSE REGULATOR receiver
MESIL_RS15040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MESIL_RS15050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MESIL_RS15055	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MESIL_RS15065	COG3584	3D domain protein
MESIL_RS15065	COG3583	domain protein
MESIL_RS15070	COG1461	Dihydroxyacetone kinase
MESIL_RS15080	COG0343	queuine tRNA-ribosyltransferase activity
MESIL_RS15085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MESIL_RS15090	COG1993	acr, cog1993
MESIL_RS15095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MESIL_RS15105	COG2720	vancomycin resistance protein
MESIL_RS15120	COG1187	pseudouridine synthase activity
MESIL_RS15130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MESIL_RS15135	COG1522	sequence-specific DNA binding
MESIL_RS15140	COG0686	Belongs to the AlaDH PNT family
MESIL_RS15155	COG0628	permease
MESIL_RS15170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MESIL_RS15180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MESIL_RS15185	COG0436	Aminotransferase
MESIL_RS15205	COG3118	belongs to the thioredoxin family
MESIL_RS15210	COG0416	fatty acid biosynthetic process
MESIL_RS15215	COG0668	transmembrane transport
MESIL_RS15230	COG2272	Belongs to the type-B carboxylesterase lipase family
MESIL_RS15235	COG0277	FAD linked oxidase domain protein
MESIL_RS15240	COG1597	lipid kinase activity
MESIL_RS15250	COG0123	including yeast histone deacetylase and acetoin utilization protein
MESIL_RS15255	COG0671	phosphoesterase, PA-phosphatase related
MESIL_RS15265	COG1515	deoxyribonuclease V activity
MESIL_RS15275	COG0714	Associated with various cellular activities
MESIL_RS15310	COG2151	metal-sulfur cluster biosynthetic enzyme
MESIL_RS15325	COG3396	Phenylacetate-CoA oxygenase
MESIL_RS15355	COG1070	Carbohydrate kinase
MESIL_RS15360	COG1070	Carbohydrate kinase
MESIL_RS15365	COG1349	DNA-binding transcription factor activity
MESIL_RS15380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MESIL_RS15385	COG1175	transmembrane transport
MESIL_RS15390	COG0395	ABC-type sugar transport system, permease component
MESIL_RS15415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MESIL_RS15420	COG1070	Carbohydrate kinase
MESIL_RS15440	COG0842	Transport permease protein
MESIL_RS15445	COG1131	(ABC) transporter
MESIL_RS15470	COG0747	negative chemotaxis
MESIL_RS15485	COG1120	ATPase activity
MESIL_RS15490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MESIL_RS15510	COG1690	Belongs to the RtcB family
MESIL_RS15525	COG0802	atpase or kinase
MESIL_RS15535	COG2223	nitrite transmembrane transporter activity
MESIL_RS15540	COG3191	aminopeptidase activity
MESIL_RS15545	COG2389	metal-binding protein
MESIL_RS15565	COG1309	transcriptional regulator
MESIL_RS15585	COG0305	Participates in initiation and elongation during chromosome replication
MESIL_RS15595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MESIL_RS15600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MESIL_RS15600	COG0072	phenylalanine-tRNA ligase activity
MESIL_RS15610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MESIL_RS15615	COG0205	6-phosphofructokinase activity
MESIL_RS15620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MESIL_RS15660	COG0251	oxidation-reduction process
MESIL_RS15670	COG0631	protein serine/threonine phosphatase activity
MESIL_RS15685	COG1166	arginine decarboxylase activity
MESIL_RS15695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MESIL_RS15700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MESIL_RS15700	COG2199	diguanylate cyclase activity
MESIL_RS15725	COG0506	proline dehydrogenase activity
MESIL_RS15735	COG1012	belongs to the aldehyde dehydrogenase family
MESIL_RS15800	COG0730	response to heat
MESIL_RS15805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MESIL_RS15830	COG0642	Histidine kinase
MESIL_RS15840	COG0671	phosphoesterase, PA-phosphatase related
MESIL_RS15870	COG2873	o-acetylhomoserine
MESIL_RS15890	COG1136	(ABC) transporter
MESIL_RS15915	COG1573	uracil-dna glycosylase
MESIL_RS15920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MESIL_RS15945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MESIL_RS15950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MESIL_RS15960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MESIL_RS15970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MESIL_RS15995	COG0521	Mo-molybdopterin cofactor biosynthetic process
MESIL_RS16005	COG1486	melibiose metabolic process
MESIL_RS16015	COG0436	Aminotransferase
MESIL_RS16020	COG2814	Major facilitator Superfamily
MESIL_RS16030	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
MESIL_RS16050	COG0584	glycerophosphoryl diester phosphodiesterase
MESIL_RS16070	COG2333	competence protein COMEC
MESIL_RS16070	COG0658	competence protein
MESIL_RS16075	COG1475	DNA binding
MESIL_RS16080	COG1192	Involved in chromosome partitioning
MESIL_RS16085	COG0357	Ribosomal RNA small subunit methyltransferase G
MESIL_RS16095	COG0445	tRNA wobble uridine modification
MESIL_RS16460	COG4585	Histidine kinase
MESIL_RS16805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MESIL_RS16805	COG0515	serine threonine protein kinase
MESIL_RS16810	COG2815	serine threonine protein kinase
MESIL_RS16810	COG0515	serine threonine protein kinase
MESIL_RS18215	COG1404	Belongs to the peptidase S8 family
MESIL_RS18445	COG2971	BadF BadG BcrA BcrD
MESIL_RS18480	COG0606	chelatase, subunit chli
MESIL_RS18520	COG1573	uracil-dna glycosylase
MESIL_RS18600	COG0835	chemotaxis
MESIL_RS18645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MESIL_RS18670	COG4585	Histidine kinase
MESIL_RS18680	COG0438	transferase activity, transferring glycosyl groups
MESIL_RS18685	COG1215	transferase activity, transferring glycosyl groups
MESIL_RS18695	COG0438	transferase activity, transferring glycosyl groups
MESIL_RS18700	COG1215	transferase activity, transferring glycosyl groups
MESIL_RS18705	COG1215	transferase activity, transferring glycosyl groups
MESIL_RS18705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MESIL_RS18715	COG0456	acetyltransferase
MESIL_RS18715	COG0454	-acetyltransferase
MESIL_RS18770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MESIL_RS18815	COG1660	Displays ATPase and GTPase activities