locus-tag	class	description
HGP13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGP13_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGP13_RS00030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGP13_RS00050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGP13_RS00060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGP13_RS00065	COG3300	MHYT domain
HGP13_RS00065	COG5001	Diguanylate cyclase
HGP13_RS00070	COG2813	Specifically methylates the guanine in position
HGP13_RS00075	COG1185	polyribonucleotide nucleotidyltransferase activity
HGP13_RS00080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGP13_RS00085	COG0598	Magnesium transport protein CorA
HGP13_RS00090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGP13_RS00095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGP13_RS00100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGP13_RS00115	COG0779	Required for maturation of 30S ribosomal subunits
HGP13_RS00125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGP13_RS00130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGP13_RS00135	COG1396	sequence-specific DNA binding
HGP13_RS00140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGP13_RS00155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGP13_RS00160	COG1702	phosphate starvation-inducible protein PhoH
HGP13_RS00165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGP13_RS00180	COG1214	PFAM Peptidase M22, glycoprotease
HGP13_RS00225	COG3609	addiction module antidote protein, CC2985 family
HGP13_RS00230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS00255	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS00265	COG0601	transmembrane transport
HGP13_RS00275	COG2951	lytic endotransglycosylase activity
HGP13_RS00280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGP13_RS00295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGP13_RS00300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGP13_RS00315	COG2816	NAD+ diphosphatase activity
HGP13_RS00330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HGP13_RS00335	COG3474	cytochrome
HGP13_RS00340	COG4166	transmembrane transport
HGP13_RS00345	COG4166	transmembrane transport
HGP13_RS00350	COG4174	ABC transporter (Permease)
HGP13_RS00355	COG4239	(ABC) transporter, permease
HGP13_RS00360	COG4172	Belongs to the ABC transporter superfamily
HGP13_RS00390	COG1793	dna ligase
HGP13_RS00415	COG1295	ribonuclease BN
HGP13_RS00430	COG1595	DNA-templated transcription, initiation
HGP13_RS00485	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HGP13_RS00500	COG0601	transmembrane transport
HGP13_RS00505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS00510	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS00540	COG1024	Enoyl-CoA hydratase
HGP13_RS00545	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS00555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS00560	COG3836	Belongs to the HpcH HpaI aldolase family
HGP13_RS00565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS00575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGP13_RS00585	COG4608	Belongs to the ABC transporter superfamily
HGP13_RS00590	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS00595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS00600	COG0601	transmembrane transport
HGP13_RS00605	COG0747	negative chemotaxis
HGP13_RS00610	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS00615	COG2264	protein methyltransferase activity
HGP13_RS00625	COG0166	Belongs to the GPI family
HGP13_RS00630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS00655	COG0129	dihydroxy-acid dehydratase activity
HGP13_RS00665	COG0489	protein tyrosine kinase activity
HGP13_RS00670	COG3706	GGDEF domain
HGP13_RS00675	COG0583	DNA-binding transcription factor activity
HGP13_RS00690	COG3383	formate dehydrogenase (NAD+) activity
HGP13_RS00695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HGP13_RS00705	COG2197	response regulator
HGP13_RS00730	COG1177	transmembrane transport
HGP13_RS00735	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS00740	COG3842	ATPase activity
HGP13_RS00745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HGP13_RS00760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGP13_RS00775	COG1349	DNA-binding transcription factor activity
HGP13_RS00790	COG2226	methyltransferase
HGP13_RS00800	COG0697	spore germination
HGP13_RS00805	COG0402	S-adenosylhomocysteine deaminase activity
HGP13_RS00810	COG1132	(ABC) transporter
HGP13_RS00815	COG0129	dihydroxy-acid dehydratase activity
HGP13_RS00825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HGP13_RS00830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS00835	COG0154	amidase activity
HGP13_RS00840	COG0121	glutamine amidotransferase
HGP13_RS00850	COG1522	sequence-specific DNA binding
HGP13_RS00855	COG0756	dUTP diphosphatase activity
HGP13_RS00860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGP13_RS00885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS00895	COG3706	GGDEF domain
HGP13_RS00900	COG0280	phosphate acetyltransferase
HGP13_RS00900	COG0281	malic enzyme
HGP13_RS00910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGP13_RS00915	COG0656	L-ascorbic acid biosynthetic process
HGP13_RS00940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HGP13_RS00945	COG0728	peptidoglycan biosynthetic process
HGP13_RS00950	COG0180	Tryptophanyl-tRNA synthetase
HGP13_RS00960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGP13_RS00965	COG1388	LysM domain
HGP13_RS00965	COG1376	ErfK ybiS ycfS ynhG family protein
HGP13_RS00980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HGP13_RS00985	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HGP13_RS00995	COG1643	Atp-dependent helicase
HGP13_RS01015	COG1175	transmembrane transport
HGP13_RS01045	COG1461	Dihydroxyacetone kinase
HGP13_RS01070	COG2376	Dihydroxyacetone kinase
HGP13_RS01110	COG3206	protein involved in exopolysaccharide biosynthesis
HGP13_RS01110	COG0489	protein tyrosine kinase activity
HGP13_RS01115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGP13_RS01120	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS01125	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS01130	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS01135	COG0438	transferase activity, transferring glycosyl groups
HGP13_RS01150	COG0463	Glycosyl transferase, family 2
HGP13_RS01165	COG2273	Hydrolase Family 16
HGP13_RS01175	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS01210	COG1132	(ABC) transporter
HGP13_RS01220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HGP13_RS01225	COG1596	polysaccharide export
HGP13_RS01235	COG3307	-O-antigen
HGP13_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS01245	COG4647	ligase activity
HGP13_RS01250	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HGP13_RS01255	COG0145	ligase activity
HGP13_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGP13_RS01280	COG0438	transferase activity, transferring glycosyl groups
HGP13_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS01310	COG0431	NADPH-dependent FMN reductase
HGP13_RS01320	COG0410	ABC transporter
HGP13_RS01340	COG0411	ABC transporter
HGP13_RS01345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS01355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS01375	COG1335	isochorismatase
HGP13_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS01415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGP13_RS01425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HGP13_RS01430	COG0539	negative regulation of cytoplasmic translation
HGP13_RS01445	COG2235	arginine
HGP13_RS01460	COG4215	(ABC) transporter
HGP13_RS01470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HGP13_RS01560	COG5001	Diguanylate cyclase
HGP13_RS01590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HGP13_RS01595	COG1063	alcohol dehydrogenase
HGP13_RS01600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HGP13_RS01605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HGP13_RS01615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGP13_RS01620	COG1609	Transcriptional regulator
HGP13_RS01650	COG0523	cobalamin synthesis protein
HGP13_RS01675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGP13_RS01690	COG1573	uracil-dna glycosylase
HGP13_RS01700	COG4702	Belongs to the UPF0303 family
HGP13_RS01705	COG0402	S-adenosylhomocysteine deaminase activity
HGP13_RS01715	COG0583	DNA-binding transcription factor activity
HGP13_RS01720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS01730	COG0384	phenazine biosynthesis protein PhzF
HGP13_RS01740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGP13_RS01750	COG2351	hydroxyisourate hydrolase activity
HGP13_RS01755	COG3648	Uricase
HGP13_RS01755	COG3195	allantoin biosynthetic process
HGP13_RS01760	COG3257	ureidoglycine aminohydrolase activity
HGP13_RS01765	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HGP13_RS01790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS01805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGP13_RS01810	COG1595	DNA-templated transcription, initiation
HGP13_RS01830	COG1609	Transcriptional regulator
HGP13_RS01835	COG1653	transport
HGP13_RS01840	COG1175	transmembrane transport
HGP13_RS01845	COG0395	ABC-type sugar transport system, permease component
HGP13_RS01850	COG0366	Alpha amylase catalytic
HGP13_RS01855	COG3842	ATPase activity
HGP13_RS01870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGP13_RS01885	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS01890	COG0463	Glycosyl transferase, family 2
HGP13_RS01930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HGP13_RS01935	COG0745	RESPONSE REGULATOR receiver
HGP13_RS01940	COG2205	protein histidine kinase activity
HGP13_RS01945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGP13_RS01950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGP13_RS01950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGP13_RS01960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HGP13_RS01965	COG2205	protein histidine kinase activity
HGP13_RS01970	COG3178	'Phosphotransferase
HGP13_RS01975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGP13_RS01980	COG2887	Belongs to the helicase family. UvrD subfamily
HGP13_RS01985	COG1074	ATP-dependent DNA helicase activity
HGP13_RS02025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGP13_RS02030	COG0159	tryptophan synthase activity
HGP13_RS02035	COG0133	tryptophan synthase activity
HGP13_RS02040	COG0135	phosphoribosylanthranilate isomerase activity
HGP13_RS02060	COG3135	benzoate transporter
HGP13_RS02070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGP13_RS02080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGP13_RS02085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGP13_RS02090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HGP13_RS02100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGP13_RS02100	COG0072	phenylalanine-tRNA ligase activity
HGP13_RS02115	COG0667	Aldo Keto reductase
HGP13_RS02150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS02180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGP13_RS02190	COG3246	L-lysine catabolic process to acetate
HGP13_RS02195	COG4977	sequence-specific DNA binding
HGP13_RS02205	COG2115	Belongs to the xylose isomerase family
HGP13_RS02215	COG1070	Carbohydrate kinase
HGP13_RS02225	COG3468	outer membrane autotransporter barrel domain protein
HGP13_RS02230	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS02235	COG1376	ErfK ybiS ycfS ynhG family protein
HGP13_RS02235	COG1388	LysM domain
HGP13_RS02240	COG0205	6-phosphofructokinase activity
HGP13_RS02245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS02255	COG1072	(Pantothenic acid kinase))
HGP13_RS02260	COG0140	phosphoribosyl-ATP diphosphatase activity
HGP13_RS02265	COG0107	imidazoleglycerol-phosphate synthase activity
HGP13_RS02275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HGP13_RS02285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGP13_RS02295	COG0131	Imidazoleglycerol-phosphate dehydratase
HGP13_RS02300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGP13_RS02315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HGP13_RS02340	COG1609	Transcriptional regulator
HGP13_RS02355	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS02365	COG0673	inositol 2-dehydrogenase activity
HGP13_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS02375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGP13_RS02400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS02405	COG3962	Belongs to the TPP enzyme family
HGP13_RS02410	COG1082	Xylose isomerase domain protein TIM barrel
HGP13_RS02420	COG3718	enzyme involved in inositol metabolism
HGP13_RS02425	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HGP13_RS02430	COG3454	Phosphonate metabolism
HGP13_RS02435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HGP13_RS02450	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS02470	COG2824	Alkylphosphonate utilization operon protein PhnA
HGP13_RS02485	COG1686	Belongs to the peptidase S11 family
HGP13_RS02495	COG1072	(Pantothenic acid kinase))
HGP13_RS02505	COG0625	glutathione transferase activity
HGP13_RS02520	COG0829	nickel cation binding
HGP13_RS02525	COG0831	urea catabolic process
HGP13_RS02530	COG3813	Protein conserved in bacteria
HGP13_RS02540	COG0832	Belongs to the urease beta subunit family
HGP13_RS02550	COG0804	urea catabolic process
HGP13_RS02565	COG0625	glutathione transferase activity
HGP13_RS02570	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HGP13_RS02575	COG0830	nickel cation binding
HGP13_RS02585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HGP13_RS02595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGP13_RS02610	COG0583	DNA-binding transcription factor activity
HGP13_RS02620	COG1175	transmembrane transport
HGP13_RS02655	COG3842	ATPase activity
HGP13_RS02660	COG1063	alcohol dehydrogenase
HGP13_RS02665	COG0395	ABC-type sugar transport system, permease component
HGP13_RS02685	COG0534	Mate efflux family protein
HGP13_RS02720	COG0765	amino acid transport
HGP13_RS02725	COG0765	amino acid transport
HGP13_RS02730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS02740	COG0583	DNA-binding transcription factor activity
HGP13_RS02745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGP13_RS02785	COG1335	isochorismatase
HGP13_RS02790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HGP13_RS02815	COG1846	Transcriptional regulator
HGP13_RS02820	COG0483	inositol monophosphate 1-phosphatase activity
HGP13_RS02825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS02830	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HGP13_RS02835	COG0628	permease
HGP13_RS02850	COG2076	Multidrug Resistance protein
HGP13_RS02880	COG0242	peptide deformylase activity
HGP13_RS02885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGP13_RS02895	COG0101	tRNA pseudouridine synthase activity
HGP13_RS02905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGP13_RS02910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGP13_RS02930	COG2171	N-acyltransferase activity
HGP13_RS02945	COG3706	GGDEF domain
HGP13_RS02980	COG3186	Phenylalanine-4-hydroxylase
HGP13_RS02985	COG1522	sequence-specific DNA binding
HGP13_RS02990	COG1032	radical SAM domain protein
HGP13_RS02995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGP13_RS03020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HGP13_RS03025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGP13_RS03045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGP13_RS03060	COG1566	PFAM secretion protein HlyD family protein
HGP13_RS03070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HGP13_RS03075	COG0706	membrane insertase activity
HGP13_RS03080	COG0594	ribonuclease P activity
HGP13_RS03085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HGP13_RS03090	COG4191	Histidine kinase
HGP13_RS03140	COG0405	Gamma-glutamyltransferase
HGP13_RS03145	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS03150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGP13_RS03190	COG0747	negative chemotaxis
HGP13_RS03215	COG1846	Transcriptional regulator
HGP13_RS03225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGP13_RS03230	COG2011	ABC-type metal ion transport system permease component
HGP13_RS03235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS03250	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HGP13_RS03265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HGP13_RS03270	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS03280	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGP13_RS03290	COG0673	inositol 2-dehydrogenase activity
HGP13_RS03295	COG0395	ABC-type sugar transport system, permease component
HGP13_RS03300	COG1175	transmembrane transport
HGP13_RS03310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HGP13_RS03315	COG2971	BadF BadG BcrA BcrD
HGP13_RS03320	COG2188	Transcriptional regulator
HGP13_RS03325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGP13_RS03330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGP13_RS03335	COG0579	oxidoreductase
HGP13_RS03340	COG4178	(ABC) transporter
HGP13_RS03350	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS03375	COG0443	Heat shock 70 kDa protein
HGP13_RS03380	COG0484	heat shock protein binding
HGP13_RS03385	COG3963	phosphatidate phosphatase activity
HGP13_RS03395	COG0284	orotidine-5'-phosphate decarboxylase activity
HGP13_RS03405	COG1802	Transcriptional regulator
HGP13_RS03420	COG3386	PFAM SMP-30 Gluconolaconase
HGP13_RS03425	COG0800	Aldolase
HGP13_RS03430	COG3734	2-keto-3-deoxy-galactonokinase
HGP13_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS03440	COG5001	Diguanylate cyclase
HGP13_RS03460	COG0189	ligase activity
HGP13_RS03520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HGP13_RS03615	COG3038	cytochrome b561
HGP13_RS03625	COG0588	phosphoglycerate mutase activity
HGP13_RS03630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HGP13_RS03635	COG1132	(ABC) transporter
HGP13_RS03640	COG0837	glucose binding
HGP13_RS03645	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HGP13_RS03655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGP13_RS03665	COG1968	undecaprenyl-diphosphatase activity
HGP13_RS03670	COG0792	nuclease activity
HGP13_RS03675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGP13_RS03690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGP13_RS03695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGP13_RS03705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HGP13_RS03710	COG1420	regulation of RNA biosynthetic process
HGP13_RS03725	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS03740	COG4941	Belongs to the sigma-70 factor family
HGP13_RS03745	COG3795	YCII-related domain
HGP13_RS03760	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HGP13_RS03800	COG0842	Transport permease protein
HGP13_RS03805	COG1131	(ABC) transporter
HGP13_RS03820	COG2954	triphosphatase activity
HGP13_RS03835	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HGP13_RS03855	COG2094	Belongs to the DNA glycosylase MPG family
HGP13_RS03860	COG0659	secondary active sulfate transmembrane transporter activity
HGP13_RS03870	COG0671	phosphoesterase, PA-phosphatase related
HGP13_RS03885	COG2197	response regulator
HGP13_RS03900	COG3634	alkyl hydroperoxide reductase activity
HGP13_RS03910	COG0842	Transport permease protein
HGP13_RS03915	COG1131	(ABC) transporter
HGP13_RS03920	COG1271	oxidase subunit
HGP13_RS03925	COG1294	oxidase, subunit
HGP13_RS03950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGP13_RS03975	COG0481	GTPase activity
HGP13_RS03985	COG0747	negative chemotaxis
HGP13_RS03990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HGP13_RS03995	COG3030	protein affecting phage T7 exclusion by the F plasmid
HGP13_RS04030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGP13_RS04050	COG0626	cystathionine gamma-synthase activity
HGP13_RS04065	COG0006	proline dipeptidase activity
HGP13_RS04070	COG1335	isochorismatase
HGP13_RS04085	COG0237	dephospho-CoA kinase activity
HGP13_RS04090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGP13_RS04095	COG0424	maF-like protein
HGP13_RS04100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HGP13_RS04105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HGP13_RS04115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGP13_RS04120	COG1331	Highly conserved protein containing a thioredoxin domain
HGP13_RS04125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGP13_RS04130	COG0445	tRNA wobble uridine modification
HGP13_RS04135	COG0357	Ribosomal RNA small subunit methyltransferase G
HGP13_RS04190	COG0463	Glycosyl transferase, family 2
HGP13_RS04195	COG0671	phosphoesterase, PA-phosphatase related
HGP13_RS04240	COG0251	oxidation-reduction process
HGP13_RS04250	COG0110	maltose O-acetyltransferase activity
HGP13_RS04255	COG2072	flavoprotein involved in K transport
HGP13_RS04310	COG3118	belongs to the thioredoxin family
HGP13_RS04315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGP13_RS04320	COG2835	tetraacyldisaccharide 4'-kinase activity
HGP13_RS04325	COG0587	DNA-directed DNA polymerase activity
HGP13_RS04335	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS04350	COG2301	Belongs to the HpcH HpaI aldolase family
HGP13_RS04365	COG0745	RESPONSE REGULATOR receiver
HGP13_RS04370	COG2205	protein histidine kinase activity
HGP13_RS04380	COG1801	Protein of unknown function DUF72
HGP13_RS04395	COG0640	Transcriptional regulator
HGP13_RS04405	COG0066	3-isopropylmalate dehydratase activity
HGP13_RS04415	COG0251	oxidation-reduction process
HGP13_RS04425	COG0473	3-isopropylmalate dehydrogenase activity
HGP13_RS04455	COG0513	Belongs to the DEAD box helicase family
HGP13_RS04460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGP13_RS04475	COG3781	membrane
HGP13_RS04500	COG0228	four-way junction DNA binding
HGP13_RS04505	COG0287	Prephenate dehydrogenase
HGP13_RS04505	COG1605	Chorismate mutase
HGP13_RS04510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGP13_RS04515	COG1266	CAAX protease self-immunity
HGP13_RS04540	COG0137	argininosuccinate synthase activity
HGP13_RS04545	COG3300	MHYT domain
HGP13_RS04545	COG5001	Diguanylate cyclase
HGP13_RS04565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGP13_RS04585	COG3339	Conserved Protein
HGP13_RS04590	COG2154	pterin-4-alpha-carbinolamine dehydratase
HGP13_RS04595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGP13_RS04600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HGP13_RS04610	COG1136	(ABC) transporter
HGP13_RS04615	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HGP13_RS04620	COG0670	Belongs to the BI1 family
HGP13_RS04645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HGP13_RS04650	COG4133	protoheme IX ABC transporter activity
HGP13_RS04655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HGP13_RS04665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGP13_RS04685	COG0431	NADPH-dependent FMN reductase
HGP13_RS04695	COG2917	probably involved in intracellular septation
HGP13_RS04700	COG0552	protein localization to endoplasmic reticulum
HGP13_RS04705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGP13_RS04710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HGP13_RS04735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HGP13_RS04740	COG0039	L-malate dehydrogenase activity
HGP13_RS04745	COG0045	succinate-CoA ligase (ADP-forming) activity
HGP13_RS04760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HGP13_RS04765	COG0567	Dehydrogenase, E1 component
HGP13_RS04770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGP13_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS04810	COG4974	Belongs to the 'phage' integrase family
HGP13_RS04815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGP13_RS04820	COG0336	Belongs to the RNA methyltransferase TrmD family
HGP13_RS04830	COG0335	large ribosomal subunit rRNA binding
HGP13_RS04835	COG1764	response to oxidative stress
HGP13_RS04840	COG1846	Transcriptional regulator
HGP13_RS04850	COG0765	amino acid transport
HGP13_RS04860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HGP13_RS04870	COG3706	GGDEF domain
HGP13_RS04915	COG3132	Protein of unknown function, DUF480
HGP13_RS04920	COG1764	response to oxidative stress
HGP13_RS04930	COG3795	YCII-related domain
HGP13_RS04945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGP13_RS04950	COG1946	Acyl-CoA thioesterase
HGP13_RS04955	COG0347	Belongs to the P(II) protein family
HGP13_RS04960	COG0004	ammonium transporteR
HGP13_RS04965	COG2261	transglycosylase associated protein
HGP13_RS04965	COG1674	ftsk spoiiie
HGP13_RS04970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGP13_RS04990	COG0745	RESPONSE REGULATOR receiver
HGP13_RS05005	COG0583	DNA-binding transcription factor activity
HGP13_RS05020	COG2264	protein methyltransferase activity
HGP13_RS05035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGP13_RS05040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGP13_RS05045	COG0181	hydroxymethylbilane synthase activity
HGP13_RS05070	COG0519	Catalyzes the synthesis of GMP from XMP
HGP13_RS05070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGP13_RS05090	COG4957	zinc ion binding
HGP13_RS05105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HGP13_RS05115	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS05120	COG1129	ABC transporter
HGP13_RS05130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS05135	COG1024	Enoyl-CoA hydratase
HGP13_RS05135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGP13_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS05175	COG3842	ATPase activity
HGP13_RS05180	COG1177	transmembrane transport
HGP13_RS05200	COG1819	glycosyl
HGP13_RS05210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS05215	COG1414	Transcriptional regulator
HGP13_RS05220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGP13_RS05225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGP13_RS05230	COG0183	Belongs to the thiolase family
HGP13_RS05270	COG1335	isochorismatase
HGP13_RS05285	COG0848	biopolymer transport protein
HGP13_RS05290	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HGP13_RS05330	COG1872	DUF167
HGP13_RS05335	COG1737	Transcriptional regulator
HGP13_RS05360	COG0395	ABC-type sugar transport system, permease component
HGP13_RS05395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HGP13_RS05405	COG1704	LemA family
HGP13_RS05410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HGP13_RS05425	COG1247	-acetyltransferase
HGP13_RS05430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGP13_RS05440	COG1309	transcriptional regulator
HGP13_RS05445	COG2271	Major facilitator Superfamily
HGP13_RS05470	COG3511	phospholipase C
HGP13_RS05495	COG2270	Major facilitator Superfamily
HGP13_RS05500	COG0138	bifunctional purine biosynthesis protein purh
HGP13_RS05510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGP13_RS05510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGP13_RS05515	COG0501	Belongs to the peptidase M48B family
HGP13_RS05525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGP13_RS05540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGP13_RS05555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGP13_RS05560	COG5425	PFAM Usg family protein
HGP13_RS05570	COG0667	Aldo Keto reductase
HGP13_RS05575	COG2814	Major facilitator Superfamily
HGP13_RS05580	COG0583	DNA-binding transcription factor activity
HGP13_RS05585	COG0667	Aldo Keto reductase
HGP13_RS05595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGP13_RS05600	COG0495	leucyl-tRNA aminoacylation
HGP13_RS05615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGP13_RS05625	COG1794	racemase activity, acting on amino acids and derivatives
HGP13_RS05635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGP13_RS05640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HGP13_RS05645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HGP13_RS05650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGP13_RS05655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HGP13_RS05660	COG0681	Belongs to the peptidase S26 family
HGP13_RS05665	COG0246	Mannitol dehydrogenase
HGP13_RS05670	COG1904	glucuronate isomerase
HGP13_RS05685	COG0514	ATP-dependent DNA helicase (RecQ)
HGP13_RS05720	COG0583	DNA-binding transcription factor activity
HGP13_RS05740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGP13_RS05740	COG3743	rRNA binding
HGP13_RS05745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGP13_RS05750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGP13_RS05755	COG0456	acetyltransferase
HGP13_RS05765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGP13_RS05770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGP13_RS05775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HGP13_RS05780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HGP13_RS05790	COG0799	negative regulation of ribosome biogenesis
HGP13_RS05795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGP13_RS05805	COG0793	Belongs to the peptidase S41A family
HGP13_RS05815	COG0494	nUDIX hydrolase
HGP13_RS05820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGP13_RS05825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS05830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGP13_RS05855	COG3744	PilT protein domain protein
HGP13_RS05865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS05870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS05905	COG0683	leucine binding
HGP13_RS05910	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HGP13_RS05915	COG3750	Belongs to the UPF0335 family
HGP13_RS05930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGP13_RS05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS05970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGP13_RS05980	COG1692	metallophosphoesterase
HGP13_RS05985	COG0861	Integral membrane protein TerC family
HGP13_RS05990	COG0217	transcriptional regulatory protein
HGP13_RS06010	COG0702	epimerase
HGP13_RS06030	COG0254	rRNA binding
HGP13_RS06035	COG1132	(ABC) transporter
HGP13_RS06060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HGP13_RS06085	COG1272	protein, Hemolysin III
HGP13_RS06090	COG0483	inositol monophosphate 1-phosphatase activity
HGP13_RS06095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGP13_RS06115	COG1522	sequence-specific DNA binding
HGP13_RS06120	COG2226	methyltransferase
HGP13_RS06145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HGP13_RS06160	COG0632	four-way junction helicase activity
HGP13_RS06165	COG2255	four-way junction helicase activity
HGP13_RS06170	COG1408	metallophosphoesterase
HGP13_RS06180	COG0824	Thioesterase
HGP13_RS06200	COG0848	biopolymer transport protein
HGP13_RS06210	COG0823	Involved in the tonB-independent uptake of proteins
HGP13_RS06220	COG2885	chlorophyll binding
HGP13_RS06230	COG0037	tRNA processing
HGP13_RS06235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGP13_RS06250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGP13_RS06265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HGP13_RS06270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGP13_RS06275	COG0697	spore germination
HGP13_RS06280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGP13_RS06320	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HGP13_RS06335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS06340	COG0765	amino acid transport
HGP13_RS06345	COG1126	abc transporter atp-binding protein
HGP13_RS06350	COG1329	Transcriptional regulator
HGP13_RS06355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HGP13_RS06370	COG1309	transcriptional regulator
HGP13_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS06385	COG0183	Belongs to the thiolase family
HGP13_RS06395	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HGP13_RS06415	COG0372	Belongs to the citrate synthase family
HGP13_RS06420	COG0372	Belongs to the citrate synthase family
HGP13_RS06455	COG2223	nitrite transmembrane transporter activity
HGP13_RS06475	COG0469	pyruvate kinase activity
HGP13_RS06490	COG0457	Tetratricopeptide repeat
HGP13_RS06495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGP13_RS06500	COG3755	Protein conserved in bacteria
HGP13_RS06505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGP13_RS06515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS06520	COG1737	Transcriptional regulator
HGP13_RS06545	COG1921	L-seryl-tRNASec selenium transferase activity
HGP13_RS06560	COG0765	amino acid transport
HGP13_RS06565	COG0765	amino acid transport
HGP13_RS06590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HGP13_RS06595	COG1196	nuclear chromosome segregation
HGP13_RS06595	COG0741	lytic transglycosylase activity
HGP13_RS06595	COG0739	heme binding
HGP13_RS06615	COG2226	methyltransferase
HGP13_RS06620	COG0784	Response regulator, receiver
HGP13_RS06620	COG2205	protein histidine kinase activity
HGP13_RS06620	COG5002	protein histidine kinase activity
HGP13_RS06630	COG2084	Dehydrogenase
HGP13_RS06635	COG3265	gluconokinase activity
HGP13_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS06650	COG1063	alcohol dehydrogenase
HGP13_RS06655	COG1609	Transcriptional regulator
HGP13_RS06670	COG1129	ABC transporter
HGP13_RS06680	COG0142	geranyltranstransferase activity
HGP13_RS06685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGP13_RS06690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HGP13_RS06740	COG0640	Transcriptional regulator
HGP13_RS06795	COG0346	lactoylglutathione lyase activity
HGP13_RS06815	COG3588	fructose-bisphosphate aldolase
HGP13_RS06820	COG0126	phosphoglycerate kinase activity
HGP13_RS06855	COG0450	alkyl hydroperoxide reductase
HGP13_RS06860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS06860	COG3453	Protein conserved in bacteria
HGP13_RS06865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGP13_RS06870	COG0564	pseudouridine synthase activity
HGP13_RS06880	COG0346	lactoylglutathione lyase activity
HGP13_RS06940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGP13_RS06945	COG0573	inorganic phosphate transmembrane transporter activity
HGP13_RS06950	COG0581	inorganic phosphate transmembrane transporter activity
HGP13_RS06955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HGP13_RS06960	COG0704	Plays a role in the regulation of phosphate uptake
HGP13_RS06965	COG0745	RESPONSE REGULATOR receiver
HGP13_RS06970	COG1940	carbohydrate kinase activity
HGP13_RS06975	COG4213	ABC transporter substrate-binding protein
HGP13_RS06980	COG4214	carbohydrate transport
HGP13_RS06985	COG1129	ABC transporter
HGP13_RS07010	COG2202	Pas domain
HGP13_RS07010	COG3920	Histidine kinase
HGP13_RS07020	COG0784	Response regulator, receiver
HGP13_RS07035	COG0784	Response regulator, receiver
HGP13_RS07040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGP13_RS07055	COG3920	Histidine kinase
HGP13_RS07065	COG1597	lipid kinase activity
HGP13_RS07080	COG0346	lactoylglutathione lyase activity
HGP13_RS07085	COG0400	carboxylic ester hydrolase activity
HGP13_RS07105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS07120	COG2226	methyltransferase
HGP13_RS07145	COG3842	ATPase activity
HGP13_RS07155	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS07165	COG4638	Rieske (2fe-2S)
HGP13_RS07180	COG2200	EAL domain
HGP13_RS07180	COG2199	diguanylate cyclase activity
HGP13_RS07180	COG2203	Gaf domain
HGP13_RS07185	COG0745	RESPONSE REGULATOR receiver
HGP13_RS07190	COG0745	RESPONSE REGULATOR receiver
HGP13_RS07210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGP13_RS07235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGP13_RS07250	COG1653	transport
HGP13_RS07255	COG1846	Transcriptional regulator
HGP13_RS07255	COG1940	carbohydrate kinase activity
HGP13_RS07260	COG0306	phosphate transporter
HGP13_RS07270	COG4689	acetoacetate decarboxylase
HGP13_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS07280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HGP13_RS07290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HGP13_RS07295	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGP13_RS07295	COG0022	dehydrogenase e1 component
HGP13_RS07300	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGP13_RS07320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGP13_RS07340	COG3732	PTS system glucitol sorbitol-specific
HGP13_RS07350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGP13_RS07360	COG2390	Transcriptional regulator
HGP13_RS07370	COG1070	Carbohydrate kinase
HGP13_RS07390	COG1129	ABC transporter
HGP13_RS07395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS07405	COG1082	Xylose isomerase domain protein TIM barrel
HGP13_RS07415	COG2132	Multicopper oxidase
HGP13_RS07520	COG4106	trans-aconitate 2-methyltransferase activity
HGP13_RS07595	COG2135	peptidase activity
HGP13_RS07625	COG1473	amidohydrolase
HGP13_RS07635	COG0523	cobalamin synthesis protein
HGP13_RS07640	COG0425	Belongs to the sulfur carrier protein TusA family
HGP13_RS07650	COG0825	malonyl-CoA metabolic process
HGP13_RS07655	COG4974	Belongs to the 'phage' integrase family
HGP13_RS07665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGP13_RS07670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HGP13_RS07675	COG4536	flavin adenine dinucleotide binding
HGP13_RS07685	COG0028	Belongs to the TPP enzyme family
HGP13_RS07730	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HGP13_RS07735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HGP13_RS07760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS07765	COG2226	methyltransferase
HGP13_RS07770	COG4178	(ABC) transporter
HGP13_RS07780	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS07795	COG2813	Specifically methylates the guanine in position
HGP13_RS07795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGP13_RS07800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGP13_RS07805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGP13_RS07810	COG0287	Prephenate dehydrogenase
HGP13_RS07875	COG2884	Cell division ATP-binding protein ftsE
HGP13_RS07905	COG0583	DNA-binding transcription factor activity
HGP13_RS07920	COG0019	diaminopimelate decarboxylase activity
HGP13_RS07930	COG0165	Argininosuccinate lyase
HGP13_RS07935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGP13_RS07940	COG5001	Diguanylate cyclase
HGP13_RS07940	COG3300	MHYT domain
HGP13_RS07945	COG1653	transport
HGP13_RS07950	COG1175	transmembrane transport
HGP13_RS07955	COG0395	ABC-type sugar transport system, permease component
HGP13_RS07960	COG3842	ATPase activity
HGP13_RS07965	COG3842	ATPase activity
HGP13_RS07990	COG5002	protein histidine kinase activity
HGP13_RS07990	COG5001	Diguanylate cyclase
HGP13_RS07990	COG3447	MASE1 domain protein
HGP13_RS07995	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGP13_RS08000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HGP13_RS08005	COG2086	electron transfer activity
HGP13_RS08025	COG0300	oxidoreductase activity
HGP13_RS08050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGP13_RS08100	COG0653	protein targeting
HGP13_RS08105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGP13_RS08120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HGP13_RS08130	COG0494	nUDIX hydrolase
HGP13_RS08145	COG2226	methyltransferase
HGP13_RS08150	COG1040	competence protein
HGP13_RS08160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGP13_RS08170	COG1846	Transcriptional regulator
HGP13_RS08180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGP13_RS08190	COG0527	aspartate kinase activity
HGP13_RS08200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGP13_RS08205	COG2890	protein-(glutamine-N5) methyltransferase activity
HGP13_RS08215	COG0542	response to heat
HGP13_RS08230	COG1376	ErfK ybiS ycfS ynhG family protein
HGP13_RS08235	COG3548	integral membrane protein
HGP13_RS08240	COG0477	Major facilitator Superfamily
HGP13_RS08245	COG0739	heme binding
HGP13_RS08280	COG3609	addiction module antidote protein, CC2985 family
HGP13_RS08330	COG4372	Transposase
HGP13_RS08335	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS08345	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS08365	COG2910	NAD(P)H-binding
HGP13_RS08380	COG3842	ATPase activity
HGP13_RS08385	COG1177	transmembrane transport
HGP13_RS08390	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS08400	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS08405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS08420	COG2188	Transcriptional regulator
HGP13_RS08425	COG1940	carbohydrate kinase activity
HGP13_RS08440	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS08445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS08450	COG1129	ABC transporter
HGP13_RS08460	COG4608	Belongs to the ABC transporter superfamily
HGP13_RS08470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS08480	COG0747	negative chemotaxis
HGP13_RS08495	COG5564	TIM-barrel signal transduction protein
HGP13_RS08500	COG5441	Belongs to the UPF0261 family
HGP13_RS08510	COG3842	ATPase activity
HGP13_RS08525	COG0395	ABC-type sugar transport system, permease component
HGP13_RS08530	COG3842	ATPase activity
HGP13_RS08540	COG3842	ATPase activity
HGP13_RS08585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGP13_RS08595	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS08610	COG0673	inositol 2-dehydrogenase activity
HGP13_RS08615	COG1082	Xylose isomerase domain protein TIM barrel
HGP13_RS08620	COG3639	organic phosphonate transmembrane transporter activity
HGP13_RS08635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HGP13_RS08650	COG4778	phosphonate C-P lyase system protein PhnL
HGP13_RS08655	COG4107	phosphonate C-P lyase system protein PhnK
HGP13_RS08660	COG3627	carbon phosphorus lyase activity
HGP13_RS08670	COG3626	phosphonate metabolism
HGP13_RS08675	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HGP13_RS08680	COG3624	Phosphonate C-P lyase system protein PhnG
HGP13_RS08685	COG2188	Transcriptional regulator
HGP13_RS08690	COG1063	alcohol dehydrogenase
HGP13_RS08695	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS08705	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS08715	COG2721	sulfolactate sulfo-lyase activity
HGP13_RS08720	COG1802	Transcriptional regulator
HGP13_RS08745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HGP13_RS08755	COG1653	transport
HGP13_RS08760	COG1175	transmembrane transport
HGP13_RS08765	COG0395	ABC-type sugar transport system, permease component
HGP13_RS08770	COG3842	ATPase activity
HGP13_RS08780	COG0673	inositol 2-dehydrogenase activity
HGP13_RS08785	COG0667	Aldo Keto reductase
HGP13_RS08810	COG2319	Wd-40 repeat
HGP13_RS08830	COG0735	belongs to the Fur family
HGP13_RS08840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGP13_RS08840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGP13_RS08845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGP13_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS08890	COG2807	transmembrane transport
HGP13_RS08900	COG2207	Transcriptional regulator
HGP13_RS08905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGP13_RS08905	COG4651	solute:proton antiporter activity
HGP13_RS08910	COG1648	precorrin-2 dehydrogenase activity
HGP13_RS08910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGP13_RS08920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGP13_RS08925	COG0175	sulfate reduction
HGP13_RS08945	COG3239	Fatty acid desaturase
HGP13_RS08955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGP13_RS08960	COG2860	membrane
HGP13_RS08975	COG0604	alcohol dehydrogenase
HGP13_RS08980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGP13_RS08985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGP13_RS08990	COG0116	Belongs to the methyltransferase superfamily
HGP13_RS08990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HGP13_RS08995	COG2378	regulation of single-species biofilm formation
HGP13_RS09020	COG0776	regulation of translation
HGP13_RS09025	COG0616	signal peptide processing
HGP13_RS09035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HGP13_RS09040	COG1137	ATPase activity
HGP13_RS09045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HGP13_RS09050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HGP13_RS09055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGP13_RS09070	COG1957	nucleoside hydrolase
HGP13_RS09075	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS09085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS09115	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HGP13_RS09145	COG5001	Diguanylate cyclase
HGP13_RS09145	COG5002	protein histidine kinase activity
HGP13_RS09180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGP13_RS09185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGP13_RS09190	COG2226	methyltransferase
HGP13_RS09195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HGP13_RS09200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGP13_RS09210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HGP13_RS09230	COG1079	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS09240	COG2900	Belongs to the SlyX family
HGP13_RS09255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGP13_RS09310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HGP13_RS09320	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HGP13_RS09325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HGP13_RS09330	COG2205	protein histidine kinase activity
HGP13_RS09340	COG2814	Major facilitator Superfamily
HGP13_RS09360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HGP13_RS09380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS09390	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS09390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS09410	COG0673	inositol 2-dehydrogenase activity
HGP13_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS09445	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS09460	COG0463	Glycosyl transferase, family 2
HGP13_RS09485	COG0531	amino acid
HGP13_RS09520	COG3842	ATPase activity
HGP13_RS09545	COG2814	Major facilitator Superfamily
HGP13_RS09570	COG3842	ATPase activity
HGP13_RS09575	COG0395	ABC-type sugar transport system, permease component
HGP13_RS09580	COG1175	transmembrane transport
HGP13_RS09585	COG1653	transport
HGP13_RS09590	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS09595	COG1024	Enoyl-CoA hydratase
HGP13_RS09610	COG1609	Transcriptional regulator
HGP13_RS09620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGP13_RS09645	COG0483	inositol monophosphate 1-phosphatase activity
HGP13_RS09670	COG0071	Belongs to the small heat shock protein (HSP20) family
HGP13_RS09685	COG0067	glutamate synthase
HGP13_RS09685	COG0069	glutamate synthase activity
HGP13_RS09685	COG0070	glutamate synthase
HGP13_RS09700	COG2951	lytic endotransglycosylase activity
HGP13_RS09705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGP13_RS09730	COG0330	HflC and HflK could
HGP13_RS09740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HGP13_RS09745	COG0737	Belongs to the 5'-nucleotidase family
HGP13_RS09755	COG5310	Homospermidine synthase
HGP13_RS09780	COG3743	rRNA binding
HGP13_RS09780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGP13_RS09790	COG2204	response regulator
HGP13_RS09795	COG3108	Peptidase M15
HGP13_RS09800	COG0800	Aldolase
HGP13_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS09820	COG3795	YCII-related domain
HGP13_RS09845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGP13_RS09860	COG0583	DNA-binding transcription factor activity
HGP13_RS09865	COG0154	amidase activity
HGP13_RS09905	COG0644	oxidoreductase
HGP13_RS09930	COG1136	(ABC) transporter
HGP13_RS09935	COG0577	efflux transmembrane transporter activity
HGP13_RS09935	COG1136	(ABC) transporter
HGP13_RS09985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGP13_RS10025	COG2814	Major facilitator Superfamily
HGP13_RS10030	COG0367	asparagine synthase
HGP13_RS10040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HGP13_RS10045	COG5443	negative regulation of bacterial-type flagellum assembly
HGP13_RS10065	COG1749	Flagellar hook protein flgE
HGP13_RS10105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGP13_RS10110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGP13_RS10115	COG1338	Plays a role in the flagellum-specific transport system
HGP13_RS10125	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HGP13_RS10135	COG1706	bacterial-type flagellum-dependent cell motility
HGP13_RS10140	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HGP13_RS10145	COG4786	Flagellar basal body rod
HGP13_RS10150	COG1677	Flagellar hook-basal body complex protein FliE
HGP13_RS10155	COG1558	bacterial-type flagellum-dependent cell motility
HGP13_RS10160	COG1815	bacterial-type flagellum-dependent cell motility
HGP13_RS10170	COG1157	protein secretion by the type III secretion system
HGP13_RS10175	COG4786	Flagellar basal body rod
HGP13_RS10185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGP13_RS10190	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGP13_RS10195	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGP13_RS10200	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGP13_RS10205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGP13_RS10220	COG2771	luxR family
HGP13_RS10225	COG0612	Peptidase, M16
HGP13_RS10245	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HGP13_RS10250	COG3842	ATPase activity
HGP13_RS10255	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS10260	COG1177	transmembrane transport
HGP13_RS10265	COG1840	ABC-type Fe3 transport system, periplasmic component
HGP13_RS10280	COG2183	response to ionizing radiation
HGP13_RS10285	COG0583	DNA-binding transcription factor activity
HGP13_RS10290	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS10305	COG1305	Transglutaminase-like
HGP13_RS10315	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS10330	COG3795	YCII-related domain
HGP13_RS10335	COG4941	Belongs to the sigma-70 factor family
HGP13_RS10340	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS10390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGP13_RS10405	COG2207	Transcriptional regulator
HGP13_RS10405	COG0662	Cupin 2, conserved barrel domain protein
HGP13_RS10465	COG1335	isochorismatase
HGP13_RS10495	COG0583	DNA-binding transcription factor activity
HGP13_RS10545	COG3300	MHYT domain
HGP13_RS10545	COG5001	Diguanylate cyclase
HGP13_RS10565	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS10575	COG0475	glutathione-regulated potassium exporter activity
HGP13_RS10600	COG4957	zinc ion binding
HGP13_RS10665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HGP13_RS10675	COG3842	ATPase activity
HGP13_RS10680	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS10685	COG1177	transmembrane transport
HGP13_RS10690	COG0583	DNA-binding transcription factor activity
HGP13_RS10710	COG0583	DNA-binding transcription factor activity
HGP13_RS10720	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS10730	COG3842	ATPase activity
HGP13_RS10750	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS10750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS10760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGP13_RS10765	COG1760	l-serine dehydratase
HGP13_RS10780	COG2801	Transposase and inactivated derivatives
HGP13_RS10790	COG0726	polysaccharide deacetylase
HGP13_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS10820	COG0559	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS10840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS10855	COG0747	negative chemotaxis
HGP13_RS10860	COG0601	transmembrane transport
HGP13_RS10870	COG4172	Belongs to the ABC transporter superfamily
HGP13_RS10925	COG4208	sulfate ABC transporter
HGP13_RS10930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS10940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS10950	COG3842	ATPase activity
HGP13_RS10955	COG0583	DNA-binding transcription factor activity
HGP13_RS10980	COG0395	ABC-type sugar transport system, permease component
HGP13_RS10985	COG0673	inositol 2-dehydrogenase activity
HGP13_RS10995	COG3963	phosphatidate phosphatase activity
HGP13_RS11015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HGP13_RS11050	COG1609	Transcriptional regulator
HGP13_RS11055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGP13_RS11070	COG1129	ABC transporter
HGP13_RS11075	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS11095	COG1396	sequence-specific DNA binding
HGP13_RS11105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS11110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS11120	COG1116	anion transmembrane transporter activity
HGP13_RS11140	COG3604	Transcriptional regulator
HGP13_RS11150	COG3842	ATPase activity
HGP13_RS11155	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS11160	COG1177	transmembrane transport
HGP13_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS11175	COG1129	ABC transporter
HGP13_RS11180	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS11185	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS11205	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS11210	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS11235	COG0022	dehydrogenase e1 component
HGP13_RS11240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGP13_RS11245	COG1414	Transcriptional regulator
HGP13_RS11250	COG3842	ATPase activity
HGP13_RS11260	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS11290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGP13_RS11300	COG3246	L-lysine catabolic process to acetate
HGP13_RS11315	COG0583	DNA-binding transcription factor activity
HGP13_RS11320	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS11330	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS11340	COG3842	ATPase activity
HGP13_RS11345	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS11350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGP13_RS11360	COG0667	Aldo Keto reductase
HGP13_RS11370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGP13_RS11375	COG0546	phosphoglycolate phosphatase activity
HGP13_RS11395	COG1850	ribulose-bisphosphate carboxylase activity
HGP13_RS11405	COG0126	phosphoglycerate kinase activity
HGP13_RS11415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGP13_RS11425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HGP13_RS11430	COG0583	DNA-binding transcription factor activity
HGP13_RS11435	COG2204	response regulator
HGP13_RS11490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGP13_RS11490	COG0316	Belongs to the HesB IscA family
HGP13_RS11525	COG0375	protein maturation
HGP13_RS11535	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HGP13_RS11570	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS11575	COG4372	Transposase
HGP13_RS11595	COG1349	DNA-binding transcription factor activity
HGP13_RS11615	COG3842	ATPase activity
HGP13_RS11635	COG0156	8-amino-7-oxononanoate synthase activity
HGP13_RS11640	COG1063	alcohol dehydrogenase
HGP13_RS11645	COG1283	sodium-dependent phosphate transmembrane transporter activity
HGP13_RS11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS11700	COG0626	cystathionine gamma-synthase activity
HGP13_RS11720	COG5383	Protein conserved in bacteria
HGP13_RS11730	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS11735	COG0436	Aminotransferase
HGP13_RS11740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS11745	COG4957	zinc ion binding
HGP13_RS11760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGP13_RS11785	COG1396	sequence-specific DNA binding
HGP13_RS11800	COG0673	inositol 2-dehydrogenase activity
HGP13_RS11805	COG0482	sulfurtransferase activity
HGP13_RS11820	COG1733	regulation of RNA biosynthetic process
HGP13_RS11835	COG2201	protein-glutamate methylesterase activity
HGP13_RS11855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGP13_RS11880	COG0435	Glutathione S-transferase
HGP13_RS11910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGP13_RS11925	COG0477	Major facilitator Superfamily
HGP13_RS11930	COG0583	DNA-binding transcription factor activity
HGP13_RS11940	COG3180	Ammonia monooxygenase
HGP13_RS11950	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS11970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HGP13_RS11975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGP13_RS11975	COG0512	Glutamine amidotransferase of anthranilate synthase
HGP13_RS11980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HGP13_RS11990	COG2814	Major facilitator Superfamily
HGP13_RS11995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGP13_RS12015	COG1335	isochorismatase
HGP13_RS12020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HGP13_RS12060	COG1435	thymidine kinase activity
HGP13_RS12070	COG4176	ABC-type proline glycine betaine transport system permease component
HGP13_RS12080	COG2205	protein histidine kinase activity
HGP13_RS12085	COG0745	RESPONSE REGULATOR receiver
HGP13_RS12105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGP13_RS12125	COG0714	Associated with various cellular activities
HGP13_RS12140	COG0617	tRNA 3'-terminal CCA addition
HGP13_RS12160	COG0408	coproporphyrinogen oxidase activity
HGP13_RS12170	COG0789	Transcriptional regulator
HGP13_RS12175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HGP13_RS12185	COG1132	(ABC) transporter
HGP13_RS12190	COG1132	(ABC) transporter
HGP13_RS12220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HGP13_RS12220	COG2857	Cytochrome c1
HGP13_RS12235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGP13_RS12260	COG0012	GTP binding
HGP13_RS12265	COG0193	aminoacyl-tRNA hydrolase activity
HGP13_RS12270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGP13_RS12285	COG1846	Transcriptional regulator
HGP13_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS12300	COG2223	nitrite transmembrane transporter activity
HGP13_RS12305	COG2207	Transcriptional regulator
HGP13_RS12310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGP13_RS12335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGP13_RS12360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGP13_RS12375	COG2205	protein histidine kinase activity
HGP13_RS12380	COG0745	RESPONSE REGULATOR receiver
HGP13_RS12385	COG1846	Transcriptional regulator
HGP13_RS12390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS12400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS12410	COG1278	Cold shock
HGP13_RS12415	COG1278	Cold shock
HGP13_RS12445	COG1278	Cold shock
HGP13_RS12495	COG0556	nucleotide-excision repair
HGP13_RS12505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGP13_RS12525	COG0583	DNA-binding transcription factor activity
HGP13_RS12530	COG2175	clavaminate synthase activity
HGP13_RS12555	COG0277	FAD linked oxidase domain protein
HGP13_RS12585	COG1597	lipid kinase activity
HGP13_RS12590	COG2084	Dehydrogenase
HGP13_RS12605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGP13_RS12610	COG1607	acyl-coa hydrolase
HGP13_RS12660	COG1253	flavin adenine dinucleotide binding
HGP13_RS12670	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HGP13_RS12695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGP13_RS12700	COG0859	PFAM glycosyl transferase family 9
HGP13_RS12710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGP13_RS12730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HGP13_RS12730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HGP13_RS12735	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HGP13_RS12740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HGP13_RS12745	COG0463	Glycosyl transferase, family 2
HGP13_RS12750	COG1522	sequence-specific DNA binding
HGP13_RS12755	COG0492	ferredoxin-NADP+ reductase activity
HGP13_RS12760	COG0583	DNA-binding transcription factor activity
HGP13_RS12770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGP13_RS12785	COG0436	Aminotransferase
HGP13_RS12795	COG5001	Diguanylate cyclase
HGP13_RS12795	COG3300	MHYT domain
HGP13_RS12800	COG0625	glutathione transferase activity
HGP13_RS12805	COG1278	Cold shock
HGP13_RS12825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGP13_RS12845	COG3755	Protein conserved in bacteria
HGP13_RS12855	COG2852	Protein conserved in bacteria
HGP13_RS12875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGP13_RS12895	COG2814	Major facilitator Superfamily
HGP13_RS12905	COG4221	oxidoreductase activity
HGP13_RS12915	COG2801	Transposase and inactivated derivatives
HGP13_RS12935	COG1914	H( )-stimulated, divalent metal cation uptake system
HGP13_RS12940	COG1321	iron dependent repressor
HGP13_RS12955	COG2321	neutral zinc metallopeptidase
HGP13_RS12965	COG4989	oxidoreductase activity
HGP13_RS12980	COG0505	Belongs to the CarA family
HGP13_RS13000	COG0789	Transcriptional regulator
HGP13_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS13015	COG0583	DNA-binding transcription factor activity
HGP13_RS13020	COG2814	Major facilitator Superfamily
HGP13_RS13050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGP13_RS13080	COG1695	Transcriptional regulator
HGP13_RS13120	COG1595	DNA-templated transcription, initiation
HGP13_RS13140	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS13155	COG0673	inositol 2-dehydrogenase activity
HGP13_RS13165	COG1522	sequence-specific DNA binding
HGP13_RS13180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HGP13_RS13185	COG0583	DNA-binding transcription factor activity
HGP13_RS13200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGP13_RS13205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGP13_RS13210	COG2197	response regulator
HGP13_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS13220	COG2862	Uncharacterized protein family, UPF0114
HGP13_RS13230	COG2983	Belongs to the UPF0260 family
HGP13_RS13240	COG2968	Membrane
HGP13_RS13285	COG1850	ribulose-bisphosphate carboxylase activity
HGP13_RS13300	COG0673	inositol 2-dehydrogenase activity
HGP13_RS13305	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS13310	COG1129	ABC transporter
HGP13_RS13320	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS13325	COG0287	Prephenate dehydrogenase
HGP13_RS13330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS13335	COG1129	ABC transporter
HGP13_RS13340	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS13345	COG0583	DNA-binding transcription factor activity
HGP13_RS13375	COG1902	pentaerythritol trinitrate reductase activity
HGP13_RS13380	COG1609	Transcriptional regulator
HGP13_RS13385	COG1063	alcohol dehydrogenase
HGP13_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS13400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS13405	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HGP13_RS13430	COG4608	Belongs to the ABC transporter superfamily
HGP13_RS13445	COG5598	trimethylamine methyltransferase
HGP13_RS13460	COG1454	alcohol dehydrogenase
HGP13_RS13465	COG3485	protocatechuate 3,4-dioxygenase
HGP13_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS13475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HGP13_RS13480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS13505	COG3454	Phosphonate metabolism
HGP13_RS13530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGP13_RS13545	COG5001	Diguanylate cyclase
HGP13_RS13545	COG3300	MHYT domain
HGP13_RS13550	COG1473	amidohydrolase
HGP13_RS13570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGP13_RS13570	COG2080	2 iron, 2 sulfur cluster binding
HGP13_RS13605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGP13_RS13660	COG4372	Transposase
HGP13_RS13665	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS13685	COG2885	chlorophyll binding
HGP13_RS13685	COG3047	cAMP biosynthetic process
HGP13_RS13740	COG4191	Histidine kinase
HGP13_RS13740	COG0784	Response regulator, receiver
HGP13_RS13790	COG0346	lactoylglutathione lyase activity
HGP13_RS13815	COG0395	ABC-type sugar transport system, permease component
HGP13_RS13820	COG1175	transmembrane transport
HGP13_RS13830	COG1609	Transcriptional regulator
HGP13_RS13865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGP13_RS13870	COG0459	protein refolding
HGP13_RS13880	COG2818	Glycosylase
HGP13_RS13890	COG4221	oxidoreductase activity
HGP13_RS13895	COG2207	Transcriptional regulator
HGP13_RS13910	COG1956	GAF domain-containing protein
HGP13_RS13930	COG3794	PFAM blue (type 1) copper domain protein
HGP13_RS13935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGP13_RS13950	COG2855	membrane
HGP13_RS13955	COG0110	maltose O-acetyltransferase activity
HGP13_RS13985	COG0667	Aldo Keto reductase
HGP13_RS13995	COG0400	carboxylic ester hydrolase activity
HGP13_RS14005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HGP13_RS14040	COG1902	pentaerythritol trinitrate reductase activity
HGP13_RS14065	COG3609	addiction module antidote protein, CC2985 family
HGP13_RS14080	COG0765	amino acid transport
HGP13_RS14125	COG0110	maltose O-acetyltransferase activity
HGP13_RS14140	COG0406	alpha-ribazole phosphatase activity
HGP13_RS14260	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS14265	COG0640	Transcriptional regulator
HGP13_RS14270	COG0667	Aldo Keto reductase
HGP13_RS14275	COG0583	DNA-binding transcription factor activity
HGP13_RS14280	COG3706	GGDEF domain
HGP13_RS14280	COG2203	Gaf domain
HGP13_RS14280	COG5001	Diguanylate cyclase
HGP13_RS14280	COG4251	negative regulation of phosphorylation
HGP13_RS14295	COG0798	PFAM Bile acid sodium symporter
HGP13_RS14310	COG0492	ferredoxin-NADP+ reductase activity
HGP13_RS14355	COG1129	ABC transporter
HGP13_RS14360	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS14415	COG3756	Protein conserved in bacteria
HGP13_RS14435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGP13_RS14445	COG1177	transmembrane transport
HGP13_RS14450	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS14460	COG3842	ATPase activity
HGP13_RS14465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS14485	COG0604	alcohol dehydrogenase
HGP13_RS14605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGP13_RS14610	COG1609	Transcriptional regulator
HGP13_RS14625	COG3206	protein involved in exopolysaccharide biosynthesis
HGP13_RS14625	COG0489	protein tyrosine kinase activity
HGP13_RS14645	COG0297	glycogen (starch) synthase activity
HGP13_RS14690	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HGP13_RS14785	COG0625	glutathione transferase activity
HGP13_RS14790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGP13_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS14845	COG0488	(ABC) transporter
HGP13_RS14865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGP13_RS14880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGP13_RS14885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGP13_RS14895	COG3842	ATPase activity
HGP13_RS14905	COG1177	transmembrane transport
HGP13_RS14910	COG0395	ABC-type sugar transport system, permease component
HGP13_RS14915	COG0326	Molecular chaperone. Has ATPase activity
HGP13_RS14925	COG0583	DNA-binding transcription factor activity
HGP13_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS14980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGP13_RS14985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGP13_RS15000	COG0583	DNA-binding transcription factor activity
HGP13_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS15080	COG0697	spore germination
HGP13_RS15105	COG0850	regulation of cytokinetic process
HGP13_RS15110	COG2894	cell division
HGP13_RS15115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HGP13_RS15135	COG2205	protein histidine kinase activity
HGP13_RS15165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGP13_RS15170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGP13_RS15185	COG3920	Histidine kinase
HGP13_RS15190	COG5006	permease, DMT superfamily
HGP13_RS15220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGP13_RS15225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HGP13_RS15230	COG2080	2 iron, 2 sulfur cluster binding
HGP13_RS15235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGP13_RS15240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HGP13_RS15245	COG2080	2 iron, 2 sulfur cluster binding
HGP13_RS15250	COG1309	transcriptional regulator
HGP13_RS15265	COG1349	DNA-binding transcription factor activity
HGP13_RS15270	COG1129	ABC transporter
HGP13_RS15275	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS15290	COG1064	alcohol dehydrogenase
HGP13_RS15300	COG0604	alcohol dehydrogenase
HGP13_RS15325	COG0656	L-ascorbic acid biosynthetic process
HGP13_RS15345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGP13_RS15405	COG2226	methyltransferase
HGP13_RS15410	COG0596	Alpha beta hydrolase
HGP13_RS15420	COG2072	flavoprotein involved in K transport
HGP13_RS15500	COG1162	GTPase activity
HGP13_RS15505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGP13_RS15530	COG0596	Alpha beta hydrolase
HGP13_RS15545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGP13_RS15545	COG2169	Transcriptional regulator
HGP13_RS15555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGP13_RS15555	COG2169	Transcriptional regulator
HGP13_RS15560	COG1733	regulation of RNA biosynthetic process
HGP13_RS15585	COG5001	Diguanylate cyclase
HGP13_RS15585	COG5002	protein histidine kinase activity
HGP13_RS15595	COG3468	outer membrane autotransporter barrel domain protein
HGP13_RS15610	COG1024	Enoyl-CoA hydratase
HGP13_RS15635	COG0583	DNA-binding transcription factor activity
HGP13_RS15640	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS15650	COG5001	Diguanylate cyclase
HGP13_RS15665	COG1522	sequence-specific DNA binding
HGP13_RS15700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS15705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGP13_RS15725	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGP13_RS15730	COG0628	permease
HGP13_RS15735	COG0583	DNA-binding transcription factor activity
HGP13_RS15740	COG2514	catechol 2,3-dioxygenase activity
HGP13_RS15760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HGP13_RS15775	COG0667	Aldo Keto reductase
HGP13_RS15790	COG3852	Histidine kinase
HGP13_RS15900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGP13_RS15915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS15920	COG1116	anion transmembrane transporter activity
HGP13_RS15960	COG1397	ADP-ribosylglycohydrolase
HGP13_RS15965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS15970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HGP13_RS15980	COG1177	transmembrane transport
HGP13_RS15985	COG3842	ATPase activity
HGP13_RS15995	COG0583	DNA-binding transcription factor activity
HGP13_RS16020	COG2986	histidine ammonia-lyase
HGP13_RS16030	COG2814	Major facilitator Superfamily
HGP13_RS16035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS16045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS16055	COG1129	ABC transporter
HGP13_RS16075	COG3842	ATPase activity
HGP13_RS16080	COG1175	transmembrane transport
HGP13_RS16105	COG0542	response to heat
HGP13_RS16115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGP13_RS16135	COG1917	Cupin 2, conserved barrel domain protein
HGP13_RS16135	COG2169	Transcriptional regulator
HGP13_RS16140	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS16145	COG1129	ABC transporter
HGP13_RS16155	COG2186	Transcriptional regulator
HGP13_RS16165	COG1086	Polysaccharide biosynthesis protein
HGP13_RS16175	COG2271	Major facilitator Superfamily
HGP13_RS16180	COG1609	Transcriptional regulator
HGP13_RS16185	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS16190	COG1129	ABC transporter
HGP13_RS16195	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS16200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS16205	COG3265	gluconokinase activity
HGP13_RS16215	COG1959	2 iron, 2 sulfur cluster binding
HGP13_RS16220	COG4150	thiosulfate binding
HGP13_RS16235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HGP13_RS16240	COG4208	sulfate ABC transporter
HGP13_RS16245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HGP13_RS16250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGP13_RS16260	COG4953	penicillin-binding protein 1C
HGP13_RS16265	COG2373	Large extracellular alpha-helical protein
HGP13_RS16270	COG0729	surface antigen
HGP13_RS16285	COG0601	transmembrane transport
HGP13_RS16290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS16305	COG5598	trimethylamine methyltransferase
HGP13_RS16330	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HGP13_RS16335	COG0493	'glutamate synthase
HGP13_RS16355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGP13_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS16380	COG1309	transcriptional regulator
HGP13_RS16425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGP13_RS16445	COG0028	Belongs to the TPP enzyme family
HGP13_RS16450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HGP13_RS16455	COG2826	transposase and inactivated derivatives, IS30 family
HGP13_RS16475	COG3706	GGDEF domain
HGP13_RS16485	COG4106	trans-aconitate 2-methyltransferase activity
HGP13_RS16505	COG2020	methyltransferase activity
HGP13_RS16520	COG1309	transcriptional regulator
HGP13_RS16530	COG4221	oxidoreductase activity
HGP13_RS16535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS16550	COG1720	tRNA m6t6A37 methyltransferase activity
HGP13_RS16595	COG2226	methyltransferase
HGP13_RS16625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HGP13_RS16630	COG3023	N-Acetylmuramoyl-L-alanine amidase
HGP13_RS16645	COG0626	cystathionine gamma-synthase activity
HGP13_RS16650	COG2001	Belongs to the MraZ family
HGP13_RS16655	COG0275	rRNA processing
HGP13_RS16670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGP13_RS16680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGP13_RS16685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGP13_RS16695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGP13_RS16700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGP13_RS16705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGP13_RS16710	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGP13_RS16715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HGP13_RS16720	COG0849	cell division
HGP13_RS16725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGP13_RS16735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGP13_RS16745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGP13_RS16765	COG0006	proline dipeptidase activity
HGP13_RS16770	COG2264	protein methyltransferase activity
HGP13_RS16775	COG1999	signal sequence binding
HGP13_RS16780	COG3038	cytochrome b561
HGP13_RS16820	COG0534	Mate efflux family protein
HGP13_RS16840	COG5598	trimethylamine methyltransferase
HGP13_RS16845	COG1116	anion transmembrane transporter activity
HGP13_RS16860	COG4566	intracellular signal transduction
HGP13_RS16865	COG4191	Histidine kinase
HGP13_RS16880	COG1609	Transcriptional regulator
HGP13_RS16910	COG0210	DNA helicase
HGP13_RS16940	COG0784	Response regulator, receiver
HGP13_RS16945	COG0784	Response regulator, receiver
HGP13_RS16945	COG4191	Histidine kinase
HGP13_RS16965	COG0277	FAD linked oxidase domain protein
HGP13_RS16990	COG2837	iron assimilation
HGP13_RS17030	COG2814	Major facilitator Superfamily
HGP13_RS17045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HGP13_RS17050	COG3585	molybdate ion transport
HGP13_RS17055	COG0725	ABC transporter, periplasmic molybdate-binding protein
HGP13_RS17060	COG4149	molybdate abc transporter
HGP13_RS17065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HGP13_RS17070	COG3585	molybdate ion transport
HGP13_RS17070	COG2005	Transcriptional regulator
HGP13_RS17075	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS17080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS17085	COG1129	ABC transporter
HGP13_RS17095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HGP13_RS17105	COG1070	Carbohydrate kinase
HGP13_RS17125	COG0330	HflC and HflK could
HGP13_RS17130	COG0330	HflC and HflK could
HGP13_RS17150	COG0560	Phosphoserine phosphatase
HGP13_RS17150	COG3830	Belongs to the UPF0237 family
HGP13_RS17155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGP13_RS17160	COG2203	Gaf domain
HGP13_RS17160	COG2199	diguanylate cyclase activity
HGP13_RS17170	COG1396	sequence-specific DNA binding
HGP13_RS17190	COG2175	clavaminate synthase activity
HGP13_RS17205	COG0028	Belongs to the TPP enzyme family
HGP13_RS17215	COG0640	Transcriptional regulator
HGP13_RS17230	COG0590	tRNA wobble adenosine to inosine editing
HGP13_RS17235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGP13_RS17265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGP13_RS17275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HGP13_RS17280	COG3158	transport of potassium into the cell
HGP13_RS17285	COG3158	transport of potassium into the cell
HGP13_RS17290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGP13_RS17300	COG1733	regulation of RNA biosynthetic process
HGP13_RS17305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGP13_RS17325	COG1309	transcriptional regulator
HGP13_RS17330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HGP13_RS17365	COG2826	transposase and inactivated derivatives, IS30 family
HGP13_RS17370	COG0697	spore germination
HGP13_RS17375	COG1136	(ABC) transporter
HGP13_RS17375	COG0577	efflux transmembrane transporter activity
HGP13_RS17380	COG1136	(ABC) transporter
HGP13_RS17380	COG0577	efflux transmembrane transporter activity
HGP13_RS17390	COG0384	phenazine biosynthesis protein PhzF
HGP13_RS17405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HGP13_RS17410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HGP13_RS17415	COG1797	cobyrinic acid a,c-diamide synthase activity
HGP13_RS17480	COG3214	Protein conserved in bacteria
HGP13_RS17490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGP13_RS17495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGP13_RS17500	COG0649	NAD binding
HGP13_RS17505	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HGP13_RS17510	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HGP13_RS17515	COG3743	rRNA binding
HGP13_RS17515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGP13_RS17525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HGP13_RS17530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGP13_RS17540	COG0713	ATP synthesis coupled electron transport
HGP13_RS17555	COG1007	ATP synthesis coupled electron transport
HGP13_RS17575	COG0346	lactoylglutathione lyase activity
HGP13_RS17590	COG0442	prolyl-tRNA aminoacylation
HGP13_RS17600	COG1136	(ABC) transporter
HGP13_RS17610	COG0321	lipoyl(octanoyl) transferase activity
HGP13_RS17720	COG3750	Belongs to the UPF0335 family
HGP13_RS17970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HGP13_RS17975	COG0045	succinate-CoA ligase (ADP-forming) activity
HGP13_RS17980	COG2301	Belongs to the HpcH HpaI aldolase family
HGP13_RS17995	COG2239	Acts as a magnesium transporter
HGP13_RS18065	COG0251	oxidation-reduction process
HGP13_RS18080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS18085	COG0402	S-adenosylhomocysteine deaminase activity
HGP13_RS18095	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGP13_RS18100	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGP13_RS18115	COG2040	homocysteine
HGP13_RS18135	COG2814	Major facilitator Superfamily
HGP13_RS18145	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS18145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS18155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS18160	COG3264	Mechanosensitive ion channel
HGP13_RS18160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HGP13_RS18170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HGP13_RS18185	COG1088	dTDP-glucose 4,6-dehydratase activity
HGP13_RS18225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS18245	COG0583	DNA-binding transcription factor activity
HGP13_RS18265	COG0646	methionine synthase
HGP13_RS18265	COG1410	methionine synthase
HGP13_RS18305	COG5012	cobalamin binding
HGP13_RS18310	COG5598	trimethylamine methyltransferase
HGP13_RS18320	COG2186	Transcriptional regulator
HGP13_RS18325	COG2807	transmembrane transport
HGP13_RS18335	COG2081	HI0933 family
HGP13_RS18345	COG2304	oxidoreductase activity
HGP13_RS18355	COG0646	methionine synthase
HGP13_RS18355	COG1410	methionine synthase
HGP13_RS18385	COG0006	proline dipeptidase activity
HGP13_RS18420	COG1505	serine-type exopeptidase activity
HGP13_RS18445	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS18455	COG1492	cobalamin metabolic process
HGP13_RS18485	COG4172	Belongs to the ABC transporter superfamily
HGP13_RS18495	COG0601	transmembrane transport
HGP13_RS18500	COG0747	negative chemotaxis
HGP13_RS18505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGP13_RS18525	COG1063	alcohol dehydrogenase
HGP13_RS18530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGP13_RS18535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGP13_RS18540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGP13_RS18585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS18595	COG1858	cytochrome C peroxidase
HGP13_RS18600	COG1522	sequence-specific DNA binding
HGP13_RS18610	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS18635	COG3720	iron ion transport
HGP13_RS18640	COG4558	Periplasmic binding protein
HGP13_RS18645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGP13_RS18650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HGP13_RS18655	COG1959	2 iron, 2 sulfur cluster binding
HGP13_RS18660	COG2733	membrane
HGP13_RS18680	COG0583	DNA-binding transcription factor activity
HGP13_RS18685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS18690	COG0697	spore germination
HGP13_RS18715	COG5002	protein histidine kinase activity
HGP13_RS18755	COG3142	Participates in the control of copper homeostasis
HGP13_RS18795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGP13_RS18835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HGP13_RS18840	COG3119	arylsulfatase activity
HGP13_RS18910	COG3338	carbonate dehydratase activity
HGP13_RS18920	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS18925	COG4372	Transposase
HGP13_RS18930	COG0668	transmembrane transport
HGP13_RS18940	COG1376	ErfK ybiS ycfS ynhG family protein
HGP13_RS18960	COG1525	nuclease
HGP13_RS19040	COG4372	Transposase
HGP13_RS19045	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS19085	COG0384	phenazine biosynthesis protein PhzF
HGP13_RS19105	COG2135	peptidase activity
HGP13_RS19190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGP13_RS19200	COG1047	Peptidyl-prolyl cis-trans
HGP13_RS19245	COG0484	heat shock protein binding
HGP13_RS19275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGP13_RS19290	COG0525	valine-tRNA ligase activity
HGP13_RS19300	COG0129	dihydroxy-acid dehydratase activity
HGP13_RS19315	COG0708	Exodeoxyribonuclease III
HGP13_RS19330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HGP13_RS19335	COG0018	arginyl-trna synthetase
HGP13_RS19350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGP13_RS19355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGP13_RS19360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGP13_RS19365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGP13_RS19370	COG0805	protein transport
HGP13_RS19375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGP13_RS19380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HGP13_RS19385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGP13_RS19405	COG1862	Preprotein translocase
HGP13_RS19435	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HGP13_RS19465	COG0544	peptidyl-prolyl cis-trans isomerase activity
HGP13_RS19485	COG2003	Belongs to the UPF0758 family
HGP13_RS19495	COG0604	alcohol dehydrogenase
HGP13_RS19515	COG0697	spore germination
HGP13_RS19635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGP13_RS19650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGP13_RS19675	COG2814	Major facilitator Superfamily
HGP13_RS19690	COG2080	2 iron, 2 sulfur cluster binding
HGP13_RS19695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HGP13_RS19700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGP13_RS19710	COG0561	phosphatase activity
HGP13_RS19715	COG3685	Protein conserved in bacteria
HGP13_RS19720	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS19750	COG1309	transcriptional regulator
HGP13_RS19760	COG4993	Dehydrogenase
HGP13_RS19770	COG0437	4 iron, 4 sulfur cluster binding
HGP13_RS19810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGP13_RS19845	COG0024	Methionine aminopeptidase
HGP13_RS19925	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HGP13_RS19990	COG3243	poly(R)-hydroxyalkanoic acid synthase
HGP13_RS20000	COG0436	Aminotransferase
HGP13_RS20020	COG1494	fructose-1,6-bisphosphatase
HGP13_RS20035	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGP13_RS20040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HGP13_RS20045	COG0302	gtp cyclohydrolase
HGP13_RS20060	COG0583	DNA-binding transcription factor activity
HGP13_RS20070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGP13_RS20080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HGP13_RS20085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGP13_RS20100	COG0778	Nitroreductase
HGP13_RS20115	COG2301	Belongs to the HpcH HpaI aldolase family
HGP13_RS20120	COG2030	dehydratase
HGP13_RS20135	COG0187	DNA topoisomerase II activity
HGP13_RS20145	COG4964	Belongs to the GSP D family
HGP13_RS20175	COG2755	lipolytic protein G-D-S-L family
HGP13_RS20175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HGP13_RS20195	COG3706	GGDEF domain
HGP13_RS20200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGP13_RS20200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGP13_RS20205	COG0509	glycine decarboxylation via glycine cleavage system
HGP13_RS20210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS20225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HGP13_RS20240	COG1671	Belongs to the UPF0178 family
HGP13_RS20245	COG3791	Glutathione-dependent formaldehyde-activating
HGP13_RS20255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGP13_RS20260	COG4770	biotin carboxylase activity
HGP13_RS20280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGP13_RS20305	COG0784	Response regulator, receiver
HGP13_RS20315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGP13_RS20320	COG4977	sequence-specific DNA binding
HGP13_RS20330	COG2186	Transcriptional regulator
HGP13_RS20335	COG0626	cystathionine gamma-synthase activity
HGP13_RS20350	COG0395	ABC-type sugar transport system, permease component
HGP13_RS20355	COG3842	ATPase activity
HGP13_RS20360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGP13_RS20385	COG0557	exoribonuclease II activity
HGP13_RS20390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGP13_RS20400	COG0785	Cytochrome C biogenesis protein
HGP13_RS20405	COG2814	Major facilitator Superfamily
HGP13_RS20410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGP13_RS20420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGP13_RS20430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGP13_RS20440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGP13_RS20445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HGP13_RS20450	COG3706	GGDEF domain
HGP13_RS20455	COG3791	Glutathione-dependent formaldehyde-activating
HGP13_RS20460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HGP13_RS20495	COG1132	(ABC) transporter
HGP13_RS20505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGP13_RS20515	COG0281	malic enzyme
HGP13_RS20515	COG0280	phosphate acetyltransferase
HGP13_RS20535	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS20540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGP13_RS20545	COG1127	ABC transporter
HGP13_RS20580	COG0633	Ferredoxin
HGP13_RS20585	COG0492	ferredoxin-NADP+ reductase activity
HGP13_RS20600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGP13_RS20605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HGP13_RS20610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGP13_RS20620	COG0475	glutathione-regulated potassium exporter activity
HGP13_RS20620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGP13_RS20635	COG3768	UPF0283 membrane protein
HGP13_RS20640	COG3106	COG3106 Predicted ATPase
HGP13_RS20665	COG0813	purine-nucleoside phosphorylase activity
HGP13_RS20730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGP13_RS20740	COG0740	serine-type endopeptidase activity
HGP13_RS20755	COG0629	single-stranded DNA binding
HGP13_RS20760	COG1765	OsmC-like protein
HGP13_RS20765	COG2095	MarC family integral membrane protein
HGP13_RS20795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGP13_RS20805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGP13_RS20825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGP13_RS20835	COG0343	queuine tRNA-ribosyltransferase activity
HGP13_RS20855	COG2308	Evidence 4 Homologs of previously reported genes of
HGP13_RS20910	COG0395	ABC-type sugar transport system, permease component
HGP13_RS20925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGP13_RS20945	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS20950	COG4372	Transposase
HGP13_RS20965	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS20975	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS21000	COG0438	transferase activity, transferring glycosyl groups
HGP13_RS21020	COG0758	DNA mediated transformation
HGP13_RS21025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGP13_RS21030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGP13_RS21035	COG0540	Belongs to the ATCase OTCase family
HGP13_RS21040	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS21055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGP13_RS21060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HGP13_RS21070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGP13_RS21080	COG0154	amidase activity
HGP13_RS21085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HGP13_RS21095	COG1760	l-serine dehydratase
HGP13_RS21105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HGP13_RS21110	COG1686	Belongs to the peptidase S11 family
HGP13_RS21120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGP13_RS21135	COG0537	adenosine 5'-monophosphoramidase activity
HGP13_RS21175	COG0052	Belongs to the universal ribosomal protein uS2 family
HGP13_RS21180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGP13_RS21195	COG0667	Aldo Keto reductase
HGP13_RS21200	COG0528	UMP kinase activity
HGP13_RS21205	COG0233	cytoplasmic translational termination
HGP13_RS21210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGP13_RS21220	COG0750	zinc metalloprotease
HGP13_RS21225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGP13_RS21230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGP13_RS21235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGP13_RS21240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGP13_RS21245	COG3494	Protein of unknown function (DUF1009)
HGP13_RS21250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGP13_RS21255	COG0372	Belongs to the citrate synthase family
HGP13_RS21260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGP13_RS21270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGP13_RS21280	COG3483	tryptophan 2,3-dioxygenase activity
HGP13_RS21295	COG0303	'Molybdopterin
HGP13_RS21300	COG0315	cyclic pyranopterin monophosphate synthase activity
HGP13_RS21305	COG0134	indole-3-glycerol-phosphate synthase activity
HGP13_RS21310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HGP13_RS21315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGP13_RS21320	COG0149	triose-phosphate isomerase activity
HGP13_RS21335	COG0504	CTP synthase activity
HGP13_RS21345	COG1953	Uracil, thiamine, allantoin
HGP13_RS21350	COG0583	DNA-binding transcription factor activity
HGP13_RS21355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGP13_RS21360	COG2267	carboxylic ester hydrolase activity
HGP13_RS21365	COG0747	negative chemotaxis
HGP13_RS21370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS21380	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS21385	COG4608	Belongs to the ABC transporter superfamily
HGP13_RS21410	COG0010	Belongs to the arginase family
HGP13_RS21490	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS21500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGP13_RS21515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HGP13_RS21520	COG2205	protein histidine kinase activity
HGP13_RS21520	COG2202	Pas domain
HGP13_RS21525	COG1525	nuclease
HGP13_RS21530	COG0625	glutathione transferase activity
HGP13_RS21535	COG1573	uracil-dna glycosylase
HGP13_RS21540	COG1522	sequence-specific DNA binding
HGP13_RS21560	COG2084	Dehydrogenase
HGP13_RS21575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS21580	COG1763	Mo-molybdopterin cofactor biosynthetic process
HGP13_RS21585	COG0746	molybdenum cofactor guanylyltransferase activity
HGP13_RS21605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGP13_RS21620	COG1846	Transcriptional regulator
HGP13_RS21665	COG0546	phosphoglycolate phosphatase activity
HGP13_RS21670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGP13_RS21695	COG4178	(ABC) transporter
HGP13_RS21715	COG4166	transmembrane transport
HGP13_RS21730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGP13_RS21745	COG1183	phosphatidylcholine synthase activity
HGP13_RS21775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGP13_RS21780	COG0861	Integral membrane protein TerC family
HGP13_RS21820	COG0484	heat shock protein binding
HGP13_RS21825	COG0582	viral genome integration into host DNA
HGP13_RS21980	COG1686	Belongs to the peptidase S11 family
HGP13_RS21985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGP13_RS22005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGP13_RS22010	COG0084	hydrolase, TatD family'
HGP13_RS22015	COG1234	tRNA 3'-trailer cleavage
HGP13_RS22040	COG0670	Belongs to the BI1 family
HGP13_RS22065	COG3956	TIGRFAM MazG family protein
HGP13_RS22070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGP13_RS22075	COG1923	regulation of RNA biosynthetic process
HGP13_RS22080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS22085	COG2204	response regulator
HGP13_RS22090	COG5000	phosphorelay sensor kinase activity
HGP13_RS22095	COG2204	response regulator
HGP13_RS22100	COG3852	Histidine kinase
HGP13_RS22110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGP13_RS22110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HGP13_RS22125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGP13_RS22135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGP13_RS22150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGP13_RS22155	COG0022	dehydrogenase e1 component
HGP13_RS22155	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGP13_RS22160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HGP13_RS22165	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HGP13_RS22170	COG0148	phosphopyruvate hydratase activity
HGP13_RS22190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HGP13_RS22205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGP13_RS22210	COG0737	Belongs to the 5'-nucleotidase family
HGP13_RS22215	COG1252	NADH dehydrogenase
HGP13_RS22220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGP13_RS22230	COG1522	sequence-specific DNA binding
HGP13_RS22235	COG0686	Belongs to the AlaDH PNT family
HGP13_RS22260	COG2897	thiosulfate sulfurtransferase activity
HGP13_RS22275	COG0300	oxidoreductase activity
HGP13_RS22285	COG0513	Belongs to the DEAD box helicase family
HGP13_RS22290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGP13_RS22295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGP13_RS22295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HGP13_RS22300	COG0347	Belongs to the P(II) protein family
HGP13_RS22305	COG0174	glutamine synthetase
HGP13_RS22325	COG0174	glutamine synthetase
HGP13_RS22355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGP13_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS22390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGP13_RS22400	COG0203	ribosomal protein L17
HGP13_RS22405	COG0202	RNA polymerase activity
HGP13_RS22410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGP13_RS22415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGP13_RS22420	COG0563	adenylate kinase activity
HGP13_RS22430	COG0200	Binds to the 23S rRNA
HGP13_RS22435	COG1841	ribosomal large subunit assembly
HGP13_RS22440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGP13_RS22445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGP13_RS22450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGP13_RS22455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGP13_RS22460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGP13_RS22465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGP13_RS22470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGP13_RS22475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGP13_RS22480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGP13_RS22485	COG0255	Belongs to the universal ribosomal protein uL29 family
HGP13_RS22490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGP13_RS22495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGP13_RS22500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGP13_RS22505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGP13_RS22510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGP13_RS22515	COG0089	rRNA binding
HGP13_RS22520	COG0088	Forms part of the polypeptide exit tunnel
HGP13_RS22525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGP13_RS22530	COG0051	transcription antitermination factor activity, RNA binding
HGP13_RS22535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGP13_RS22540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGP13_RS22545	COG0049	tRNA binding
HGP13_RS22550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGP13_RS22575	COG4122	O-methyltransferase activity
HGP13_RS22580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGP13_RS22585	COG0085	RNA polymerase activity
HGP13_RS22590	COG0222	ribosome binding
HGP13_RS22595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGP13_RS22600	COG0081	regulation of translation
HGP13_RS22605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGP13_RS22615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGP13_RS22640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGP13_RS22670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGP13_RS22675	COG2084	Dehydrogenase
HGP13_RS22680	COG3622	Belongs to the hyi family
HGP13_RS22685	COG3960	tartronate-semialdehyde synthase activity
HGP13_RS22690	COG1414	Transcriptional regulator
HGP13_RS22755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HGP13_RS22765	COG4208	sulfate ABC transporter
HGP13_RS22770	COG3842	ATPase activity
HGP13_RS22775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS22795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGP13_RS22800	COG0513	Belongs to the DEAD box helicase family
HGP13_RS22810	COG2885	chlorophyll binding
HGP13_RS22830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HGP13_RS22835	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGP13_RS22840	COG1530	ribonuclease E activity
HGP13_RS22845	COG2066	Belongs to the glutaminase family
HGP13_RS22850	COG0436	Aminotransferase
HGP13_RS22865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HGP13_RS22870	COG0511	ligase activity, forming carbon-carbon bonds
HGP13_RS22880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HGP13_RS22905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGP13_RS22910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HGP13_RS22925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGP13_RS22930	COG3811	Belongs to the UPF0386 family
HGP13_RS22935	COG0516	GMP reductase activity
HGP13_RS22935	COG0517	IMP dehydrogenase activity
HGP13_RS23020	COG1278	Cold shock
HGP13_RS23025	COG0346	lactoylglutathione lyase activity
HGP13_RS23040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HGP13_RS23075	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HGP13_RS23115	COG2986	histidine ammonia-lyase
HGP13_RS23120	COG0494	nUDIX hydrolase
HGP13_RS23125	COG1902	pentaerythritol trinitrate reductase activity
HGP13_RS23145	COG2267	carboxylic ester hydrolase activity
HGP13_RS23150	COG1546	Belongs to the CinA family
HGP13_RS23150	COG1058	Belongs to the CinA family
HGP13_RS23160	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HGP13_RS23175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGP13_RS23190	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS23230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGP13_RS23240	COG0583	DNA-binding transcription factor activity
HGP13_RS23265	COG0586	Pfam SNARE associated Golgi protein
HGP13_RS23280	COG1968	undecaprenyl-diphosphatase activity
HGP13_RS23310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGP13_RS23315	COG3246	L-lysine catabolic process to acetate
HGP13_RS23335	COG0667	Aldo Keto reductase
HGP13_RS23365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGP13_RS23370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HGP13_RS23370	COG3608	succinylglutamate desuccinylase aspartoacylase
HGP13_RS23390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGP13_RS23400	COG3191	aminopeptidase activity
HGP13_RS23420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGP13_RS23425	COG2514	catechol 2,3-dioxygenase activity
HGP13_RS23450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGP13_RS23455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGP13_RS23465	COG0047	phosphoribosylformylglycinamidine synthase activity
HGP13_RS23490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS23500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGP13_RS23525	COG0483	inositol monophosphate 1-phosphatase activity
HGP13_RS23530	COG0037	tRNA processing
HGP13_RS23535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGP13_RS23560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HGP13_RS23565	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HGP13_RS23570	COG0538	isocitrate dehydrogenase activity
HGP13_RS23595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGP13_RS23600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGP13_RS23610	COG2313	pseudouridylate synthase activity
HGP13_RS23620	COG3791	Glutathione-dependent formaldehyde-activating
HGP13_RS23625	COG0316	Belongs to the HesB IscA family
HGP13_RS23630	COG2151	metal-sulfur cluster biosynthetic enzyme
HGP13_RS23635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGP13_RS23640	COG0719	Fe-S assembly protein
HGP13_RS23645	COG0396	ATPase activity
HGP13_RS23655	COG0719	Fe-S assembly protein
HGP13_RS23665	COG2945	thiolester hydrolase activity
HGP13_RS23675	COG0671	phosphoesterase, PA-phosphatase related
HGP13_RS23680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HGP13_RS23690	COG0463	Glycosyl transferase, family 2
HGP13_RS23695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGP13_RS23705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGP13_RS23720	COG0739	heme binding
HGP13_RS23725	COG1473	amidohydrolase
HGP13_RS23730	COG0006	proline dipeptidase activity
HGP13_RS23750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS23785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS23795	COG3842	ATPase activity
HGP13_RS23805	COG1175	transmembrane transport
HGP13_RS23810	COG0395	ABC-type sugar transport system, permease component
HGP13_RS23835	COG0776	regulation of translation
HGP13_RS23845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGP13_RS23850	COG0740	serine-type endopeptidase activity
HGP13_RS23860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS23860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HGP13_RS23865	COG2124	cytochrome p450
HGP13_RS23885	COG1832	CoA-binding protein
HGP13_RS23890	COG1196	nuclear chromosome segregation
HGP13_RS23920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGP13_RS23925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGP13_RS23960	COG0010	Belongs to the arginase family
HGP13_RS23965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HGP13_RS23975	COG1612	heme a metabolic process
HGP13_RS24000	COG3842	ATPase activity
HGP13_RS24015	COG0395	ABC-type sugar transport system, permease component
HGP13_RS24040	COG0297	glycogen (starch) synthase activity
HGP13_RS24060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGP13_RS24090	COG0776	regulation of translation
HGP13_RS24095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGP13_RS24100	COG0416	fatty acid biosynthetic process
HGP13_RS24115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGP13_RS24125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HGP13_RS24130	COG1174	glycine betaine transport
HGP13_RS24135	COG1125	glycine betaine transport
HGP13_RS24140	COG1174	glycine betaine transport
HGP13_RS24145	COG1732	Glycine betaine
HGP13_RS24150	COG2814	Major facilitator Superfamily
HGP13_RS24155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGP13_RS24160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGP13_RS24170	COG4453	Protein conserved in bacteria
HGP13_RS24180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGP13_RS24180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGP13_RS24185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGP13_RS24190	COG3136	membrane protein required for alginate biosynthesis
HGP13_RS24200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGP13_RS24205	COG0025	NhaP-type Na H and K H
HGP13_RS24210	COG2197	response regulator
HGP13_RS24215	COG2989	Protein conserved in bacteria
HGP13_RS24230	COG1024	Enoyl-CoA hydratase
HGP13_RS24240	COG0113	porphobilinogen synthase activity
HGP13_RS24270	COG0667	Aldo Keto reductase
HGP13_RS24330	COG0306	phosphate transporter
HGP13_RS24335	COG1392	Phosphate transport regulator
HGP13_RS24355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HGP13_RS24365	COG0628	permease
HGP13_RS24370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGP13_RS24380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGP13_RS24390	COG0738	Major facilitator superfamily
HGP13_RS24400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HGP13_RS24425	COG0477	Major facilitator Superfamily
HGP13_RS24450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGP13_RS24585	COG0714	Associated with various cellular activities
HGP13_RS24615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HGP13_RS24620	COG1132	(ABC) transporter
HGP13_RS24625	COG3459	Glycosyltransferase 36 associated
HGP13_RS24635	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HGP13_RS24650	COG2986	histidine ammonia-lyase
HGP13_RS24655	COG1228	amidohydrolase
HGP13_RS24660	COG0402	S-adenosylhomocysteine deaminase activity
HGP13_RS24665	COG2188	Transcriptional regulator
HGP13_RS24670	COG0251	oxidation-reduction process
HGP13_RS24680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGP13_RS24685	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGP13_RS24725	COG1234	tRNA 3'-trailer cleavage
HGP13_RS24730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HGP13_RS24740	COG1063	alcohol dehydrogenase
HGP13_RS24745	COG0156	8-amino-7-oxononanoate synthase activity
HGP13_RS24755	COG0726	polysaccharide deacetylase
HGP13_RS24770	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS24770	COG1902	pentaerythritol trinitrate reductase activity
HGP13_RS24775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGP13_RS24790	COG0747	negative chemotaxis
HGP13_RS24795	COG5598	trimethylamine methyltransferase
HGP13_RS24815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGP13_RS24850	COG1663	tetraacyldisaccharide 4'-kinase activity
HGP13_RS24855	COG1519	Transferase
HGP13_RS24870	COG0483	inositol monophosphate 1-phosphatase activity
HGP13_RS24875	COG0312	modulator of DNA gyrase
HGP13_RS24890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGP13_RS24895	COG2072	flavoprotein involved in K transport
HGP13_RS24905	COG2144	transferase activity, transferring acyl groups
HGP13_RS24930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS24940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGP13_RS24945	COG0702	epimerase
HGP13_RS24950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS24980	COG0612	Peptidase, M16
HGP13_RS24985	COG0612	Peptidase, M16
HGP13_RS24990	COG0742	ribosomal rna small subunit methyltransferase
HGP13_RS25000	COG0590	tRNA wobble adenosine to inosine editing
HGP13_RS25010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGP13_RS25030	COG0196	riboflavin kinase activity
HGP13_RS25045	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS25060	COG1230	cation diffusion facilitator family transporter
HGP13_RS25070	COG2239	Acts as a magnesium transporter
HGP13_RS25080	COG2340	Cysteine-rich secretory protein family
HGP13_RS25085	COG2814	Major facilitator Superfamily
HGP13_RS25090	COG1566	PFAM secretion protein HlyD family protein
HGP13_RS25100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGP13_RS25105	COG2267	carboxylic ester hydrolase activity
HGP13_RS25110	COG0671	phosphoesterase, PA-phosphatase related
HGP13_RS25110	COG2453	phosphatase
HGP13_RS25125	COG4589	Belongs to the CDS family
HGP13_RS25130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGP13_RS25140	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HGP13_RS25150	COG1609	Transcriptional regulator
HGP13_RS25155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS25160	COG1129	ABC transporter
HGP13_RS25170	COG2207	Transcriptional regulator
HGP13_RS25170	COG3708	Transcriptional regulator
HGP13_RS25175	COG1846	Transcriptional regulator
HGP13_RS25175	COG0456	acetyltransferase
HGP13_RS25220	COG0459	protein refolding
HGP13_RS25240	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS25265	COG1278	Cold shock
HGP13_RS25280	COG3237	CsbD-like
HGP13_RS25300	COG1309	transcriptional regulator
HGP13_RS25315	COG0114	fumarate hydratase activity
HGP13_RS25320	COG2259	Doxx family
HGP13_RS25335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGP13_RS25345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGP13_RS25360	COG1126	abc transporter atp-binding protein
HGP13_RS25365	COG0765	amino acid transport
HGP13_RS25370	COG4597	amino acid ABC transporter
HGP13_RS25375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS25390	COG0626	cystathionine gamma-synthase activity
HGP13_RS25400	COG1024	Enoyl-CoA hydratase
HGP13_RS25425	COG0438	transferase activity, transferring glycosyl groups
HGP13_RS25430	COG5001	Diguanylate cyclase
HGP13_RS25430	COG5002	protein histidine kinase activity
HGP13_RS25430	COG3447	MASE1 domain protein
HGP13_RS25465	COG0628	permease
HGP13_RS25475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGP13_RS25480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGP13_RS25505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS25520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HGP13_RS25540	COG1473	amidohydrolase
HGP13_RS25550	COG1522	sequence-specific DNA binding
HGP13_RS25555	COG2072	flavoprotein involved in K transport
HGP13_RS25565	COG0243	molybdopterin cofactor binding
HGP13_RS25570	COG0488	(ABC) transporter
HGP13_RS25575	COG4957	zinc ion binding
HGP13_RS25615	COG0105	UTP biosynthetic process
HGP13_RS25620	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HGP13_RS25625	COG0314	molybdopterin synthase activity
HGP13_RS25635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGP13_RS25640	COG0322	excinuclease ABC activity
HGP13_RS25655	COG0625	glutathione transferase activity
HGP13_RS25670	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS25690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGP13_RS25715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGP13_RS25760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGP13_RS25785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HGP13_RS25790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGP13_RS25795	COG0194	GDP metabolic process
HGP13_RS25800	COG1561	YicC-like family, N-terminal region
HGP13_RS25805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGP13_RS25810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGP13_RS25815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGP13_RS25825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGP13_RS25830	COG1368	sulfuric ester hydrolase activity
HGP13_RS25840	COG0360	Binds together with S18 to 16S ribosomal RNA
HGP13_RS25845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGP13_RS25850	COG0359	binds to the 23S rRNA
HGP13_RS25855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGP13_RS25860	COG1742	UPF0060 membrane protein
HGP13_RS25885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGP13_RS25890	COG4221	oxidoreductase activity
HGP13_RS25905	COG0697	spore germination
HGP13_RS25915	COG0583	DNA-binding transcription factor activity
HGP13_RS25925	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS25925	COG0204	Acyl-transferase
HGP13_RS25930	COG1183	phosphatidylcholine synthase activity
HGP13_RS25935	COG0688	phosphatidylethanolamine metabolic process
HGP13_RS25950	COG3386	PFAM SMP-30 Gluconolaconase
HGP13_RS25960	COG5265	(ABC) transporter
HGP13_RS25965	COG0640	Transcriptional regulator
HGP13_RS25970	COG0583	DNA-binding transcription factor activity
HGP13_RS25980	COG1652	LysM domain
HGP13_RS25990	COG0583	DNA-binding transcription factor activity
HGP13_RS26010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGP13_RS26035	COG0215	cysteine-tRNA ligase activity
HGP13_RS26075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGP13_RS26080	COG0354	folic acid binding
HGP13_RS26085	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HGP13_RS26090	COG5001	Diguanylate cyclase
HGP13_RS26100	COG0583	DNA-binding transcription factor activity
HGP13_RS26125	COG1595	DNA-templated transcription, initiation
HGP13_RS26135	COG1381	Involved in DNA repair and RecF pathway recombination
HGP13_RS26150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGP13_RS26155	COG0571	ribonuclease III activity
HGP13_RS26160	COG0681	Belongs to the peptidase S26 family
HGP13_RS26165	COG0736	holo-[acyl-carrier-protein] synthase activity
HGP13_RS26180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGP13_RS26190	COG1758	RNA polymerase activity
HGP13_RS26210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGP13_RS26215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS26220	COG0741	lytic transglycosylase activity
HGP13_RS26250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGP13_RS26255	COG0456	acetyltransferase
HGP13_RS26255	COG1846	Transcriptional regulator
HGP13_RS26260	COG1254	Belongs to the acylphosphatase family
HGP13_RS26270	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS26280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGP13_RS26325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HGP13_RS26350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGP13_RS26410	COG0308	aminopeptidase N
HGP13_RS26415	COG2205	protein histidine kinase activity
HGP13_RS26415	COG2202	Pas domain
HGP13_RS26425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HGP13_RS26435	COG0745	RESPONSE REGULATOR receiver
HGP13_RS26440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGP13_RS26445	COG3088	subunit of a heme lyase
HGP13_RS26450	COG1138	Cytochrome C-type biogenesis protein
HGP13_RS26455	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HGP13_RS26460	COG4235	cytochrome complex assembly
HGP13_RS26470	COG5002	protein histidine kinase activity
HGP13_RS26475	COG0745	RESPONSE REGULATOR receiver
HGP13_RS26490	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS26520	COG3842	ATPase activity
HGP13_RS26555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS26570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS26585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HGP13_RS26615	COG3409	Peptidoglycan-binding domain 1 protein
HGP13_RS26615	COG3757	hydrolase, family 25
HGP13_RS26620	COG2205	protein histidine kinase activity
HGP13_RS26630	COG2166	iron-sulfur cluster assembly
HGP13_RS26650	COG1280	lysine exporter protein (LysE YggA)
HGP13_RS26660	COG2010	Cytochrome c
HGP13_RS26665	COG3909	cytochrome
HGP13_RS26670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGP13_RS26675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS26690	COG0433	COG0433 Predicted ATPase
HGP13_RS26710	COG3654	unkown
HGP13_RS26730	COG0183	Belongs to the thiolase family
HGP13_RS26735	COG1309	transcriptional regulator
HGP13_RS26740	COG3119	arylsulfatase activity
HGP13_RS26750	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HGP13_RS26755	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS26805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGP13_RS26835	COG2010	Cytochrome c
HGP13_RS26860	COG0517	IMP dehydrogenase activity
HGP13_RS26865	COG3794	PFAM blue (type 1) copper domain protein
HGP13_RS26870	COG3976	FMN-binding domain protein
HGP13_RS26870	COG1053	succinate dehydrogenase
HGP13_RS26890	COG0745	RESPONSE REGULATOR receiver
HGP13_RS26930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HGP13_RS26940	COG4191	Histidine kinase
HGP13_RS26950	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGP13_RS26950	COG0022	dehydrogenase e1 component
HGP13_RS27010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGP13_RS27010	COG0045	succinate-CoA ligase (ADP-forming) activity
HGP13_RS27010	COG1042	CoA-binding domain protein
HGP13_RS27015	COG2217	Heavy metal translocating P-type atpase
HGP13_RS27020	COG3118	belongs to the thioredoxin family
HGP13_RS27065	COG2235	arginine
HGP13_RS27070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGP13_RS27080	COG0515	serine threonine protein kinase
HGP13_RS27080	COG2815	serine threonine protein kinase
HGP13_RS27135	COG4172	Belongs to the ABC transporter superfamily
HGP13_RS27140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS27145	COG0601	transmembrane transport
HGP13_RS27150	COG4166	transmembrane transport
HGP13_RS27165	COG0366	Alpha amylase catalytic
HGP13_RS27170	COG1523	belongs to the glycosyl hydrolase 13 family
HGP13_RS27175	COG0033	Phosphoglucomutase
HGP13_RS27180	COG0297	glycogen (starch) synthase activity
HGP13_RS27185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HGP13_RS27190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HGP13_RS27195	COG0058	SHG alpha-glucan phosphorylase activity
HGP13_RS27235	COG1218	3'(2'),5'-bisphosphate nucleotidase
HGP13_RS27245	COG0175	sulfate reduction
HGP13_RS27250	COG3307	-O-antigen
HGP13_RS27260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HGP13_RS27275	COG0438	transferase activity, transferring glycosyl groups
HGP13_RS27310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGP13_RS27315	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HGP13_RS27325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGP13_RS27330	COG1091	dTDP-4-dehydrorhamnose reductase activity
HGP13_RS27335	COG1088	dTDP-glucose 4,6-dehydratase activity
HGP13_RS27340	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HGP13_RS27355	COG1268	BioY protein
HGP13_RS27370	COG1177	transmembrane transport
HGP13_RS27375	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS27380	COG3842	ATPase activity
HGP13_RS27390	COG1609	Transcriptional regulator
HGP13_RS27425	COG0574	Belongs to the PEP-utilizing enzyme family
HGP13_RS27425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGP13_RS27460	COG1396	sequence-specific DNA binding
HGP13_RS27475	COG1196	nuclear chromosome segregation
HGP13_RS27480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGP13_RS27490	COG1194	a g-specific adenine glycosylase
HGP13_RS27500	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGP13_RS27505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGP13_RS27520	COG0612	Peptidase, M16
HGP13_RS27525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGP13_RS27535	COG1678	Uncharacterized ACR, COG1678
HGP13_RS27545	COG0678	peroxiredoxin activity
HGP13_RS27560	COG0328	RNA-DNA hybrid ribonuclease activity
HGP13_RS27565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGP13_RS27570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HGP13_RS27575	COG3346	SURF1 family
HGP13_RS27590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HGP13_RS27600	COG0109	protoheme IX farnesyltransferase activity
HGP13_RS27605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGP13_RS27610	COG1565	acr, cog1565
HGP13_RS27610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGP13_RS27625	COG0312	modulator of DNA gyrase
HGP13_RS27640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGP13_RS27660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGP13_RS27665	COG1741	Belongs to the pirin family
HGP13_RS27675	COG1722	exodeoxyribonuclease VII activity
HGP13_RS27680	COG0123	including yeast histone deacetylase and acetoin utilization protein
HGP13_RS27685	COG0778	Nitroreductase
HGP13_RS27695	COG1309	transcriptional regulator
HGP13_RS27705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGP13_RS27705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGP13_RS27710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGP13_RS27720	COG0406	alpha-ribazole phosphatase activity
HGP13_RS27725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGP13_RS27730	COG0484	heat shock protein binding
HGP13_RS27740	COG0259	pyridoxamine-phosphate oxidase activity
HGP13_RS27745	COG1024	Enoyl-CoA hydratase
HGP13_RS27750	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS27770	COG0151	Belongs to the GarS family
HGP13_RS27780	COG0583	DNA-binding transcription factor activity
HGP13_RS27785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HGP13_RS27800	COG0277	FAD linked oxidase domain protein
HGP13_RS27805	COG0009	L-threonylcarbamoyladenylate synthase
HGP13_RS27825	COG0751	glycine-tRNA ligase activity
HGP13_RS27835	COG0752	glycyl-tRNA synthetase alpha subunit
HGP13_RS27865	COG0142	geranyltranstransferase activity
HGP13_RS27890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGP13_RS27895	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGP13_RS27915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGP13_RS27920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGP13_RS27925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGP13_RS27935	COG0356	it plays a direct role in the translocation of protons across the membrane
HGP13_RS27955	COG0583	DNA-binding transcription factor activity
HGP13_RS27960	COG1160	GTP binding
HGP13_RS27965	COG2976	Protein conserved in bacteria
HGP13_RS27975	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HGP13_RS27980	COG0477	Major facilitator Superfamily
HGP13_RS27990	COG0583	DNA-binding transcription factor activity
HGP13_RS27995	COG2309	aminopeptidase activity
HGP13_RS28000	COG3189	MarR family transcriptional regulator
HGP13_RS28005	COG1393	Belongs to the ArsC family
HGP13_RS28015	COG3842	ATPase activity
HGP13_RS28030	COG1177	transmembrane transport
HGP13_RS28035	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS28050	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS28075	COG2017	converts alpha-aldose to the beta-anomer
HGP13_RS28085	COG1129	ABC transporter
HGP13_RS28090	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS28100	COG1309	transcriptional regulator
HGP13_RS28115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGP13_RS28120	COG0583	DNA-binding transcription factor activity
HGP13_RS28135	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS28145	COG0747	negative chemotaxis
HGP13_RS28150	COG0601	transmembrane transport
HGP13_RS28155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS28165	COG0583	DNA-binding transcription factor activity
HGP13_RS28170	COG0747	negative chemotaxis
HGP13_RS28185	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS28195	COG2113	Glycine betaine
HGP13_RS28200	COG4175	Glycine betaine
HGP13_RS28200	COG0517	IMP dehydrogenase activity
HGP13_RS28205	COG4176	ABC-type proline glycine betaine transport system permease component
HGP13_RS28240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS28260	COG0531	amino acid
HGP13_RS28275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGP13_RS28280	COG2218	PFAM glutamate synthase alpha subunit domain protein
HGP13_RS28285	COG0069	glutamate synthase activity
HGP13_RS28295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS28300	COG4311	Sarcosine oxidase, delta subunit
HGP13_RS28305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS28305	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS28315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS28345	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS28355	COG3347	Dehydrogenase
HGP13_RS28355	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS28370	COG1129	ABC transporter
HGP13_RS28375	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HGP13_RS28380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HGP13_RS28385	COG1522	sequence-specific DNA binding
HGP13_RS28395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGP13_RS28400	COG2376	Dihydroxyacetone kinase
HGP13_RS28410	COG0698	ribose 5-phosphate isomerase
HGP13_RS28415	COG0149	triose-phosphate isomerase activity
HGP13_RS28455	COG3842	ATPase activity
HGP13_RS28470	COG1175	transmembrane transport
HGP13_RS28475	COG1653	transport
HGP13_RS28485	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HGP13_RS28495	COG0714	Associated with various cellular activities
HGP13_RS28510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGP13_RS28520	COG0174	glutamine synthetase
HGP13_RS28535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HGP13_RS28545	COG2204	response regulator
HGP13_RS28550	COG4191	Histidine kinase
HGP13_RS28555	COG1301	dicarboxylic acid transport
HGP13_RS28560	COG1940	carbohydrate kinase activity
HGP13_RS28580	COG0673	inositol 2-dehydrogenase activity
HGP13_RS28590	COG0395	ABC-type sugar transport system, permease component
HGP13_RS28595	COG1175	transmembrane transport
HGP13_RS28610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS28620	COG1349	DNA-binding transcription factor activity
HGP13_RS28625	COG0673	inositol 2-dehydrogenase activity
HGP13_RS28650	COG3485	protocatechuate 3,4-dioxygenase
HGP13_RS28655	COG3485	protocatechuate 3,4-dioxygenase
HGP13_RS28660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGP13_RS28665	COG2267	carboxylic ester hydrolase activity
HGP13_RS28670	COG0583	DNA-binding transcription factor activity
HGP13_RS28705	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS28740	COG3842	ATPase activity
HGP13_RS28750	COG1177	transmembrane transport
HGP13_RS28755	COG0277	FAD linked oxidase domain protein
HGP13_RS28770	COG0667	Aldo Keto reductase
HGP13_RS28800	COG0559	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS28810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS28815	COG1802	Transcriptional regulator
HGP13_RS28820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGP13_RS28830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGP13_RS28880	COG3618	amidohydrolase
HGP13_RS28895	COG1175	transmembrane transport
HGP13_RS28900	COG0395	ABC-type sugar transport system, permease component
HGP13_RS28905	COG3842	ATPase activity
HGP13_RS28910	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS28950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGP13_RS28960	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS28970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HGP13_RS28990	COG1349	DNA-binding transcription factor activity
HGP13_RS29005	COG2986	histidine ammonia-lyase
HGP13_RS29010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGP13_RS29015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS29020	COG1132	(ABC) transporter
HGP13_RS29025	COG1132	(ABC) transporter
HGP13_RS29075	COG1063	alcohol dehydrogenase
HGP13_RS29080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGP13_RS29085	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS29090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGP13_RS29095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS29100	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS29110	COG1335	isochorismatase
HGP13_RS29135	COG1744	ABC transporter substrate-binding protein PnrA-like
HGP13_RS29165	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HGP13_RS29180	COG0583	DNA-binding transcription factor activity
HGP13_RS29185	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS29195	COG0251	oxidation-reduction process
HGP13_RS29200	COG2072	flavoprotein involved in K transport
HGP13_RS29215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS29280	COG2885	chlorophyll binding
HGP13_RS29325	COG0129	dihydroxy-acid dehydratase activity
HGP13_RS29330	COG3501	Rhs element vgr protein
HGP13_RS29365	COG0739	heme binding
HGP13_RS29400	COG0456	acetyltransferase
HGP13_RS29405	COG1177	transmembrane transport
HGP13_RS29415	COG3842	ATPase activity
HGP13_RS29425	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS29430	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS29470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HGP13_RS29480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGP13_RS29505	COG5265	(ABC) transporter
HGP13_RS29510	COG4988	ABC transporter
HGP13_RS29515	COG1271	oxidase subunit
HGP13_RS29520	COG1294	oxidase, subunit
HGP13_RS29535	COG0583	DNA-binding transcription factor activity
HGP13_RS29545	COG0583	DNA-binding transcription factor activity
HGP13_RS29555	COG1064	alcohol dehydrogenase
HGP13_RS29570	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HGP13_RS29580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HGP13_RS29595	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS29605	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS29610	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS29620	COG1653	transport
HGP13_RS29635	COG3842	ATPase activity
HGP13_RS29640	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS29655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGP13_RS29660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGP13_RS29665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS29670	COG1116	anion transmembrane transporter activity
HGP13_RS29675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGP13_RS29685	COG0243	molybdopterin cofactor binding
HGP13_RS29695	COG0395	ABC-type sugar transport system, permease component
HGP13_RS29700	COG1175	transmembrane transport
HGP13_RS29710	COG1802	Transcriptional regulator
HGP13_RS29860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGP13_RS29880	COG2197	response regulator
HGP13_RS29885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGP13_RS29890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HGP13_RS29895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGP13_RS29905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HGP13_RS29910	COG4310	Domain of unknown function (DUF2172)
HGP13_RS29915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGP13_RS29950	COG0438	transferase activity, transferring glycosyl groups
HGP13_RS29960	COG0297	glycogen (starch) synthase activity
HGP13_RS29970	COG1596	polysaccharide export
HGP13_RS30025	COG0583	DNA-binding transcription factor activity
HGP13_RS30035	COG4221	oxidoreductase activity
HGP13_RS30040	COG0406	alpha-ribazole phosphatase activity
HGP13_RS30045	COG0668	transmembrane transport
HGP13_RS30080	COG1247	-acetyltransferase
HGP13_RS30100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS30105	COG0601	transmembrane transport
HGP13_RS30145	COG1234	tRNA 3'-trailer cleavage
HGP13_RS30155	COG1132	(ABC) transporter
HGP13_RS30155	COG1132	(ABC) transporter
HGP13_RS30165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGP13_RS30195	COG0457	Tetratricopeptide repeat
HGP13_RS30215	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HGP13_RS30225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGP13_RS30265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGP13_RS30275	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS30280	COG0473	3-isopropylmalate dehydrogenase activity
HGP13_RS30285	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS30290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS30305	COG0454	-acetyltransferase
HGP13_RS30330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS30340	COG1522	sequence-specific DNA binding
HGP13_RS30360	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HGP13_RS30370	COG0583	DNA-binding transcription factor activity
HGP13_RS30375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS30405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGP13_RS30415	COG1793	dna ligase
HGP13_RS30440	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS30450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HGP13_RS30500	COG1175	transmembrane transport
HGP13_RS30515	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS30520	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS30545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGP13_RS30555	COG2353	YceI-like domain
HGP13_RS30565	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS30580	COG5441	Belongs to the UPF0261 family
HGP13_RS30590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGP13_RS30605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGP13_RS30610	COG1846	Transcriptional regulator
HGP13_RS30625	COG3384	dioxygenase
HGP13_RS30635	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGP13_RS30640	COG3971	2-oxopent-4-enoate hydratase activity
HGP13_RS30665	COG2207	Transcriptional regulator
HGP13_RS30710	COG0583	DNA-binding transcription factor activity
HGP13_RS30735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGP13_RS30740	COG0745	RESPONSE REGULATOR receiver
HGP13_RS30760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGP13_RS30775	COG0583	DNA-binding transcription factor activity
HGP13_RS30805	COG1396	sequence-specific DNA binding
HGP13_RS30820	COG1335	isochorismatase
HGP13_RS30825	COG1741	Belongs to the pirin family
HGP13_RS30830	COG0583	DNA-binding transcription factor activity
HGP13_RS30875	COG0583	DNA-binding transcription factor activity
HGP13_RS30905	COG3335	DDE superfamily endonuclease
HGP13_RS30910	COG3415	Transposase
HGP13_RS30945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGP13_RS30965	COG1725	Transcriptional regulator
HGP13_RS30970	COG0747	negative chemotaxis
HGP13_RS30975	COG0601	transmembrane transport
HGP13_RS30985	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS30995	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HGP13_RS31000	COG1063	alcohol dehydrogenase
HGP13_RS31005	COG1879	ABC-type sugar transport system periplasmic component
HGP13_RS31015	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS31020	COG1802	Transcriptional regulator
HGP13_RS31040	COG3293	Transposase
HGP13_RS31055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGP13_RS31075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HGP13_RS31085	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS31125	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS31130	COG4372	Transposase
HGP13_RS31145	COG1802	Transcriptional regulator
HGP13_RS31155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS31175	COG2721	sulfolactate sulfo-lyase activity
HGP13_RS31190	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS31195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HGP13_RS31205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HGP13_RS31255	COG1309	transcriptional regulator
HGP13_RS31275	COG0596	Alpha beta hydrolase
HGP13_RS31290	COG4957	zinc ion binding
HGP13_RS31300	COG2948	multi-organism process
HGP13_RS31310	COG3701	Conjugal transfer protein
HGP13_RS31315	COG3846	protein secretion by the type IV secretion system
HGP13_RS31330	COG3451	type IV secretory pathway VirB4
HGP13_RS31340	COG3838	Conjugal transfer protein Trbc
HGP13_RS31345	COG4962	Type ii secretion system protein e
HGP13_RS31355	COG3550	peptidyl-serine autophosphorylation
HGP13_RS31380	COG0741	lytic transglycosylase activity
HGP13_RS31420	COG5489	Protein of unknown function (DUF736)
HGP13_RS31450	COG4227	nucleotidyltransferase activity
HGP13_RS31485	COG0671	phosphoesterase, PA-phosphatase related
HGP13_RS31490	COG1597	lipid kinase activity
HGP13_RS31495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HGP13_RS31505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGP13_RS31515	COG1295	ribonuclease BN
HGP13_RS31585	COG3608	succinylglutamate desuccinylase aspartoacylase
HGP13_RS31590	COG0006	proline dipeptidase activity
HGP13_RS31595	COG2423	ornithine cyclodeaminase activity
HGP13_RS31600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HGP13_RS31610	COG0765	amino acid transport
HGP13_RS31615	COG0765	amino acid transport
HGP13_RS31620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS31625	COG1126	abc transporter atp-binding protein
HGP13_RS31630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS31635	COG1522	sequence-specific DNA binding
HGP13_RS31640	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS31645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGP13_RS31695	COG0110	maltose O-acetyltransferase activity
HGP13_RS31790	COG0625	glutathione transferase activity
HGP13_RS31805	COG1741	Belongs to the pirin family
HGP13_RS31835	COG4566	intracellular signal transduction
HGP13_RS31840	COG4191	Histidine kinase
HGP13_RS31845	COG0601	transmembrane transport
HGP13_RS31850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS31860	COG0747	negative chemotaxis
HGP13_RS31880	COG4566	intracellular signal transduction
HGP13_RS31885	COG2204	response regulator
HGP13_RS31890	COG4566	intracellular signal transduction
HGP13_RS31895	COG4191	Histidine kinase
HGP13_RS31920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGP13_RS31920	COG0517	IMP dehydrogenase activity
HGP13_RS31955	COG3550	peptidyl-serine autophosphorylation
HGP13_RS32005	COG3177	Filamentation induced by cAMP protein fic
HGP13_RS32015	COG0519	Catalyzes the synthesis of GMP from XMP
HGP13_RS32015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGP13_RS32040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HGP13_RS32045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGP13_RS32045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGP13_RS32050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HGP13_RS32055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HGP13_RS32060	COG0583	DNA-binding transcription factor activity
HGP13_RS32075	COG0387	Pfam Sodium calcium exchanger
HGP13_RS32080	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS32085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HGP13_RS32090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HGP13_RS32095	COG0124	histidyl-tRNA synthetase
HGP13_RS32110	COG2818	Glycosylase
HGP13_RS32115	COG1376	ErfK ybiS ycfS ynhG family protein
HGP13_RS32120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGP13_RS32125	COG0247	lactate metabolic process
HGP13_RS32130	COG0277	FAD linked oxidase domain protein
HGP13_RS32135	COG0277	FAD linked oxidase domain protein
HGP13_RS32150	COG1304	FMN binding
HGP13_RS32190	COG0583	DNA-binding transcription factor activity
HGP13_RS32200	COG1570	exodeoxyribonuclease VII activity
HGP13_RS32235	COG1312	Catalyzes the dehydration of D-mannonate
HGP13_RS32240	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS32260	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HGP13_RS32275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGP13_RS32280	COG1845	cytochrome c oxidase, subunit III
HGP13_RS32285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGP13_RS32290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGP13_RS32295	COG0477	Major facilitator Superfamily
HGP13_RS32300	COG2130	NADP-dependent
HGP13_RS32315	COG3938	Belongs to the proline racemase family
HGP13_RS32320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS32325	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS32330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HGP13_RS32335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGP13_RS32350	COG1129	ABC transporter
HGP13_RS32370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGP13_RS32375	COG1116	anion transmembrane transporter activity
HGP13_RS32380	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGP13_RS32390	COG0235	Class ii aldolase
HGP13_RS32410	COG0596	Alpha beta hydrolase
HGP13_RS32410	COG2945	thiolester hydrolase activity
HGP13_RS32415	COG2188	Transcriptional regulator
HGP13_RS32440	COG5490	Phasin protein
HGP13_RS32445	COG2205	protein histidine kinase activity
HGP13_RS32450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGP13_RS32465	COG1177	transmembrane transport
HGP13_RS32470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS32475	COG3842	ATPase activity
HGP13_RS32495	COG2224	Isocitrate lyase
HGP13_RS32515	COG0174	glutamine synthetase
HGP13_RS32520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS32530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGP13_RS32540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HGP13_RS32545	COG0363	glucosamine-6-phosphate deaminase activity
HGP13_RS32550	COG0129	dihydroxy-acid dehydratase activity
HGP13_RS32555	COG2304	oxidoreductase activity
HGP13_RS32565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGP13_RS32580	COG1396	sequence-specific DNA binding
HGP13_RS32595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HGP13_RS32625	COG2132	Multicopper oxidase
HGP13_RS32710	COG4964	Belongs to the GSP D family
HGP13_RS32760	COG2274	protein secretion by the type I secretion system
HGP13_RS32805	COG3706	GGDEF domain
HGP13_RS32910	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS32915	COG4372	Transposase
HGP13_RS32955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGP13_RS32965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGP13_RS32970	COG5328	Belongs to the UPF0262 family
HGP13_RS32980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGP13_RS32985	COG0424	maF-like protein
HGP13_RS32990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HGP13_RS32995	COG1486	melibiose metabolic process
HGP13_RS33000	COG4172	Belongs to the ABC transporter superfamily
HGP13_RS33005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS33010	COG0601	transmembrane transport
HGP13_RS33015	COG0747	negative chemotaxis
HGP13_RS33020	COG1486	melibiose metabolic process
HGP13_RS33025	COG2207	Transcriptional regulator
HGP13_RS33025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGP13_RS33055	COG2207	Transcriptional regulator
HGP13_RS33065	COG0582	viral genome integration into host DNA
HGP13_RS33075	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGP13_RS33130	COG3177	Filamentation induced by cAMP protein fic
HGP13_RS33160	COG2010	Cytochrome c
HGP13_RS33190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGP13_RS33200	COG2948	multi-organism process
HGP13_RS33225	COG3451	type IV secretory pathway VirB4
HGP13_RS33235	COG3838	Conjugal transfer protein Trbc
HGP13_RS33240	COG4962	Type ii secretion system protein e
HGP13_RS33270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGP13_RS33285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGP13_RS33290	COG3916	Acyl-homoserine-lactone synthase
HGP13_RS33310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS33390	COG0745	RESPONSE REGULATOR receiver
HGP13_RS33430	COG1304	FMN binding
HGP13_RS33440	COG1657	PFAM Prenyltransferase squalene oxidase
HGP13_RS33445	COG0142	geranyltranstransferase activity
HGP13_RS33450	COG2124	cytochrome p450
HGP13_RS33455	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS33460	COG2124	cytochrome p450
HGP13_RS33465	COG2124	cytochrome p450
HGP13_RS33500	COG4581	dead DEAH box helicase
HGP13_RS33510	COG4717	serine-type aminopeptidase activity
HGP13_RS33515	COG0420	3'-5' exonuclease activity
HGP13_RS33535	COG1525	nuclease
HGP13_RS33565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGP13_RS33570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGP13_RS33590	COG4959	Type IV secretory pathway protease TraF
HGP13_RS33620	COG0583	DNA-binding transcription factor activity
HGP13_RS33625	COG3153	acetyltransferase
HGP13_RS33630	COG3594	Acyltransferase
HGP13_RS33640	COG0583	DNA-binding transcription factor activity
HGP13_RS33660	COG0726	polysaccharide deacetylase
HGP13_RS33680	COG2192	nodulation
HGP13_RS33690	COG1131	(ABC) transporter
HGP13_RS33695	COG1215	transferase activity, transferring glycosyl groups
HGP13_RS33700	COG3153	acetyltransferase
HGP13_RS33725	COG1475	DNA binding
HGP13_RS33810	COG1525	nuclease
HGP13_RS33830	COG1864	DNA RNA non-specific endonuclease
HGP13_RS33830	COG3591	Belongs to the peptidase S1B family
HGP13_RS33885	COG3047	cAMP biosynthetic process
HGP13_RS33900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGP13_RS33915	COG4957	zinc ion binding
HGP13_RS33920	COG1278	Cold shock
HGP13_RS33930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGP13_RS33935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGP13_RS33940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGP13_RS33980	COG2197	response regulator
HGP13_RS33985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGP13_RS33990	COG1522	sequence-specific DNA binding
HGP13_RS33995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HGP13_RS33995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HGP13_RS34005	COG0583	DNA-binding transcription factor activity
HGP13_RS34010	COG2301	Belongs to the HpcH HpaI aldolase family
HGP13_RS34020	COG3799	methylaspartate ammonia-lyase activity
HGP13_RS34030	COG2226	methyltransferase
HGP13_RS34065	COG5433	transposase activity
HGP13_RS34070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS34085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS34085	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS34095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS34120	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS34125	COG3842	ATPase activity
HGP13_RS34155	COG2963	transposase activity
HGP13_RS34160	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS34165	COG3842	ATPase activity
HGP13_RS34175	COG1473	amidohydrolase
HGP13_RS34190	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS34195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HGP13_RS34195	COG0456	acetyltransferase
HGP13_RS34210	COG0154	amidase activity
HGP13_RS34225	COG3608	succinylglutamate desuccinylase aspartoacylase
HGP13_RS34285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HGP13_RS34290	COG0436	Aminotransferase
HGP13_RS34300	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS34350	COG2801	Transposase and inactivated derivatives
HGP13_RS34355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGP13_RS34360	COG0583	DNA-binding transcription factor activity
HGP13_RS34385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGP13_RS34390	COG0318	PFAM AMP-dependent synthetase and ligase
HGP13_RS34400	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HGP13_RS34425	COG2771	luxR family
HGP13_RS34445	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGP13_RS34490	COG0156	8-amino-7-oxononanoate synthase activity
HGP13_RS34505	COG0367	asparagine synthase
HGP13_RS34515	COG4974	Belongs to the 'phage' integrase family
HGP13_RS34520	COG3547	Transposase (IS116 IS110 IS902 family)
HGP13_RS34530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS34535	COG0316	Belongs to the HesB IscA family
HGP13_RS34545	COG0602	queuosine metabolic process
HGP13_RS34550	COG0720	synthase
HGP13_RS34555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGP13_RS34595	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HGP13_RS34610	COG3383	formate dehydrogenase (NAD+) activity
HGP13_RS34635	COG0745	RESPONSE REGULATOR receiver
HGP13_RS34645	COG1433	Dinitrogenase iron-molybdenum cofactor
HGP13_RS34650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HGP13_RS34655	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HGP13_RS34660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HGP13_RS34665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HGP13_RS34670	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HGP13_RS34705	COG0210	DNA helicase
HGP13_RS34710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS34720	COG4608	Belongs to the ABC transporter superfamily
HGP13_RS34725	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS34735	COG1349	DNA-binding transcription factor activity
HGP13_RS34740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGP13_RS34750	COG0367	asparagine synthase
HGP13_RS34765	COG1213	nucleotidyl transferase
HGP13_RS34780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS34790	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS34795	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HGP13_RS34805	COG2124	cytochrome p450
HGP13_RS34820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HGP13_RS34830	COG3383	formate dehydrogenase (NAD+) activity
HGP13_RS34835	COG5420	small protein containing a coiled-coil domain
HGP13_RS34840	COG5265	(ABC) transporter
HGP13_RS34850	COG1104	cysteine desulfurase activity
HGP13_RS34860	COG2086	electron transfer activity
HGP13_RS34865	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HGP13_RS34870	COG0644	oxidoreductase
HGP13_RS34885	COG0535	radical SAM domain protein
HGP13_RS34895	COG5554	nitrogen fixation
HGP13_RS34900	COG5554	nitrogen fixation
HGP13_RS34910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGP13_RS34915	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HGP13_RS34950	COG2204	response regulator
HGP13_RS34955	COG4191	Histidine kinase
HGP13_RS34960	COG1301	dicarboxylic acid transport
HGP13_RS34970	COG3604	Transcriptional regulator
HGP13_RS34980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGP13_RS34990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGP13_RS34995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HGP13_RS35010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGP13_RS35025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGP13_RS35035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HGP13_RS35085	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS35125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGP13_RS35135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGP13_RS35140	COG0720	synthase
HGP13_RS35145	COG0602	queuosine metabolic process
HGP13_RS35150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HGP13_RS35165	COG2022	thiamine diphosphate biosynthetic process
HGP13_RS35180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGP13_RS35185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGP13_RS35220	COG1222	aaa ATPase
HGP13_RS35260	COG4957	zinc ion binding
HGP13_RS35270	COG2130	NADP-dependent
HGP13_RS35295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HGP13_RS35320	COG0582	viral genome integration into host DNA
HGP13_RS35365	COG4952	isomerase
HGP13_RS35370	COG3347	Dehydrogenase
HGP13_RS35370	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS35375	COG1349	DNA-binding transcription factor activity
HGP13_RS35385	COG1129	ABC transporter
HGP13_RS35390	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS35395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGP13_RS35400	COG3254	rhamnose metabolic process
HGP13_RS35405	COG1070	Carbohydrate kinase
HGP13_RS35410	COG3457	Alanine racemase
HGP13_RS35415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS35425	COG0156	8-amino-7-oxononanoate synthase activity
HGP13_RS35430	COG0436	Aminotransferase
HGP13_RS35435	COG1970	mechanosensitive ion channel activity
HGP13_RS35440	COG2205	protein histidine kinase activity
HGP13_RS35440	COG0784	Response regulator, receiver
HGP13_RS35440	COG2198	Histidine kinase
HGP13_RS35460	COG0167	dihydroorotate dehydrogenase activity
HGP13_RS35465	COG0534	Mate efflux family protein
HGP13_RS35470	COG0123	including yeast histone deacetylase and acetoin utilization protein
HGP13_RS35500	COG0745	RESPONSE REGULATOR receiver
HGP13_RS35505	COG0642	Histidine kinase
HGP13_RS35510	COG0463	Glycosyl transferase, family 2
HGP13_RS35525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HGP13_RS35525	COG2755	lipolytic protein G-D-S-L family
HGP13_RS35555	COG1129	ABC transporter
HGP13_RS35560	COG4214	carbohydrate transport
HGP13_RS35570	COG0717	Belongs to the dCTP deaminase family
HGP13_RS35585	COG2967	ApaG domain
HGP13_RS35595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGP13_RS35600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGP13_RS35610	COG0598	Magnesium transport protein CorA
HGP13_RS35615	COG0704	Plays a role in the regulation of phosphate uptake
HGP13_RS35620	COG5002	protein histidine kinase activity
HGP13_RS35625	COG2326	polyphosphate kinase activity
HGP13_RS35630	COG1024	Enoyl-CoA hydratase
HGP13_RS35640	COG2197	response regulator
HGP13_RS35645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS35655	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HGP13_RS35675	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGP13_RS35675	COG1024	Enoyl-CoA hydratase
HGP13_RS35680	COG0183	Belongs to the thiolase family
HGP13_RS35685	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS35690	COG1960	acyl-CoA dehydrogenase activity
HGP13_RS35695	COG0789	Transcriptional regulator
HGP13_RS35705	COG0730	response to heat
HGP13_RS35715	COG0443	Heat shock 70 kDa protein
HGP13_RS35725	COG0243	molybdopterin cofactor binding
HGP13_RS35730	COG0437	4 iron, 4 sulfur cluster binding
HGP13_RS35735	COG3302	dmso reductase anchor subunit
HGP13_RS35745	COG1201	RNA secondary structure unwinding
HGP13_RS35750	COG0791	NLP P60 protein
HGP13_RS35760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGP13_RS35795	COG4964	Belongs to the GSP D family
HGP13_RS35835	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HGP13_RS35840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HGP13_RS35845	COG1024	Enoyl-CoA hydratase
HGP13_RS35850	COG0268	Binds directly to 16S ribosomal RNA
HGP13_RS35855	COG1192	Involved in chromosome partitioning
HGP13_RS35860	COG1475	DNA binding
HGP13_RS35865	COG1414	Transcriptional regulator
HGP13_RS35875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGP13_RS35955	COG4245	von Willebrand factor, type A
HGP13_RS35965	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HGP13_RS35975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGP13_RS36015	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HGP13_RS36020	COG1126	abc transporter atp-binding protein
HGP13_RS36025	COG0765	amino acid transport
HGP13_RS36030	COG0765	amino acid transport
HGP13_RS36045	COG0154	amidase activity
HGP13_RS36050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS36060	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS36060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGP13_RS36085	COG1104	cysteine desulfurase activity
HGP13_RS36100	COG5490	Phasin protein
HGP13_RS36120	COG4227	nucleotidyltransferase activity
HGP13_RS36140	COG4974	Belongs to the 'phage' integrase family
HGP13_RS36180	COG2963	transposase activity
HGP13_RS36205	COG4974	Belongs to the 'phage' integrase family
HGP13_RS36210	COG0582	viral genome integration into host DNA
HGP13_RS36215	COG4974	Belongs to the 'phage' integrase family
HGP13_RS36225	COG4974	Belongs to the 'phage' integrase family
HGP13_RS36230	COG0517	IMP dehydrogenase activity
HGP13_RS36275	COG3831	ATPase activity
HGP13_RS36285	COG2151	metal-sulfur cluster biosynthetic enzyme
HGP13_RS36285	COG0489	protein tyrosine kinase activity
HGP13_RS36315	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HGP13_RS36320	COG2948	multi-organism process
HGP13_RS36335	COG3704	protein secretion by the type IV secretion system
HGP13_RS36350	COG3451	type IV secretory pathway VirB4
HGP13_RS36365	COG0741	lytic transglycosylase activity
HGP13_RS36365	COG0739	heme binding
HGP13_RS36365	COG1196	nuclear chromosome segregation
HGP13_RS36465	COG4957	zinc ion binding
HGP13_RS36470	COG1278	Cold shock
HGP13_RS36480	COG5490	Phasin protein
HGP13_RS36495	COG3300	MHYT domain
HGP13_RS36495	COG5001	Diguanylate cyclase
HGP13_RS36520	COG1487	ribonuclease activity
HGP13_RS36525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HGP13_RS36530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGP13_RS36540	COG1278	Cold shock
HGP13_RS36545	COG3706	GGDEF domain
HGP13_RS36550	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS36555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HGP13_RS36570	COG2022	thiamine diphosphate biosynthetic process
HGP13_RS36590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGP13_RS36595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HGP13_RS36625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HGP13_RS36630	COG1522	sequence-specific DNA binding
HGP13_RS36645	COG3800	Transcriptional regulator
HGP13_RS36645	COG1396	sequence-specific DNA binding
HGP13_RS36650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGP13_RS36655	COG4770	biotin carboxylase activity
HGP13_RS36660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HGP13_RS36660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HGP13_RS36665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGP13_RS36670	COG0156	8-amino-7-oxononanoate synthase activity
HGP13_RS36685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGP13_RS36690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HGP13_RS36695	COG2814	Major facilitator Superfamily
HGP13_RS36755	COG4166	transmembrane transport
HGP13_RS36770	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS36795	COG0156	8-amino-7-oxononanoate synthase activity
HGP13_RS36810	COG1473	amidohydrolase
HGP13_RS36830	COG0517	IMP dehydrogenase activity
HGP13_RS36835	COG4974	Belongs to the 'phage' integrase family
HGP13_RS36840	COG4974	Belongs to the 'phage' integrase family
HGP13_RS36845	COG0582	viral genome integration into host DNA
HGP13_RS36875	COG1522	sequence-specific DNA binding
HGP13_RS36880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGP13_RS36915	COG2843	Capsule synthesis protein
HGP13_RS36920	COG4608	Belongs to the ABC transporter superfamily
HGP13_RS36925	COG0444	Belongs to the ABC transporter superfamily
HGP13_RS36930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGP13_RS36935	COG0601	transmembrane transport
HGP13_RS36940	COG0747	negative chemotaxis
HGP13_RS36950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGP13_RS36955	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS36960	COG1522	sequence-specific DNA binding
HGP13_RS36965	COG3448	diguanylate cyclase activity
HGP13_RS36965	COG4175	Glycine betaine
HGP13_RS36970	COG4176	ABC-type proline glycine betaine transport system permease component
HGP13_RS36980	COG0006	proline dipeptidase activity
HGP13_RS36985	COG1522	sequence-specific DNA binding
HGP13_RS37000	COG1473	amidohydrolase
HGP13_RS37005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HGP13_RS37010	COG2423	ornithine cyclodeaminase activity
HGP13_RS37025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGP13_RS37030	COG3608	succinylglutamate desuccinylase aspartoacylase
HGP13_RS37040	COG0006	proline dipeptidase activity
HGP13_RS37055	COG0765	amino acid transport
HGP13_RS37060	COG1126	abc transporter atp-binding protein
HGP13_RS37065	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS37170	COG3436	PFAM IS66 Orf2 family protein
HGP13_RS37190	COG4948	Mandelate Racemase Muconate Lactonizing
HGP13_RS37195	COG0583	DNA-binding transcription factor activity
HGP13_RS37205	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGP13_RS37205	COG1902	pentaerythritol trinitrate reductase activity
HGP13_RS37225	COG0006	proline dipeptidase activity
HGP13_RS37230	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS37235	COG1028	Short-chain dehydrogenase reductase Sdr
HGP13_RS37250	COG5598	trimethylamine methyltransferase
HGP13_RS37260	COG2113	Glycine betaine
HGP13_RS37265	COG4176	ABC-type proline glycine betaine transport system permease component
HGP13_RS37285	COG3938	Belongs to the proline racemase family
HGP13_RS37290	COG0583	DNA-binding transcription factor activity
HGP13_RS37295	COG1053	succinate dehydrogenase
HGP13_RS37305	COG1012	belongs to the aldehyde dehydrogenase family
HGP13_RS37345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGP13_RS37355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGP13_RS37365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGP13_RS37375	COG3842	ATPase activity
HGP13_RS37380	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGP13_RS37405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGP13_RS37415	COG3621	Patatin-like phospholipase
HGP13_RS37420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGP13_RS37425	COG4644	lycopene metabolic process
HGP13_RS37445	COG0326	Molecular chaperone. Has ATPase activity
HGP13_RS37510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves