locus-tag	class	description
GWK48_RS00065	ENOG4108JJB	ABC transporter
GWK48_RS00085	ENOG4105CHR	reductase
GWK48_RS00105	ENOG4105EFA	4-hydroxyphenylacetate
GWK48_RS00130	ENOG4107QNK	)-transporter
GWK48_RS00170	ENOG4108IUW	ABC transporter
GWK48_RS00205	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GWK48_RS00210	ENOG4105C9X	ppx gppa phosphatase
GWK48_RS00275	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
GWK48_RS00290	ENOG4105CPQ	Dehydrogenase
GWK48_RS00310	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
GWK48_RS00340	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
GWK48_RS00390	ENOG4105CIG	ABC transporter
GWK48_RS00395	ENOG4105C57	major facilitator superfamily
GWK48_RS00400	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
GWK48_RS00405	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GWK48_RS00420	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
GWK48_RS00440	ENOG4105C26	Dehydrogenase
GWK48_RS00450	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GWK48_RS00455	ENOG4105CSH	Transporter
GWK48_RS00480	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
GWK48_RS00485	ENOG41089BK	Glutamine amido-transferase
GWK48_RS00490	ENOG4107YEI	lmbE family
GWK48_RS00495	ENOG4105CXK	mandelate racemase muconate lactonizing
GWK48_RS00505	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK48_RS00515	ENOG4108IEG	Formate dehydrogenase Alpha subunit
GWK48_RS00525	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
GWK48_RS00560	ENOG4105BZP	glycoside hydrolase 15-related
GWK48_RS00575	ENOG4105ETU	transcriptional activator (TenA
GWK48_RS00580	ENOG4106HK8	GPR1 FUN34 yaaH family protein
GWK48_RS00585	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GWK48_RS00590	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
GWK48_RS00630	ENOG4105ERH	Fumarylacetoacetate hydrolase
GWK48_RS00645	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GWK48_RS00655	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
GWK48_RS00735	ENOG4105RD7	BadF BadG BcrA BcrD
GWK48_RS00740	ENOG4105DHP	deoxycytidine triphosphate deaminase
GWK48_RS00745	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
GWK48_RS00750	ENOG4108R96	Methyltransferase, YaeB family
GWK48_RS00785	ENOG4107RGD	Major Facilitator superfamily
GWK48_RS00790	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
GWK48_RS00800	ENOG4105CGK	Exodeoxyribonuclease III
GWK48_RS00820	ENOG4108JJB	ABC transporter
GWK48_RS00835	ENOG4105CP7	Triose-phosphate isomerase
GWK48_RS00845	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
GWK48_RS00850	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
GWK48_RS00865	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GWK48_RS00870	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GWK48_RS00905	ENOG4107QM5	aconitate hydratase
GWK48_RS00970	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GWK48_RS00975	ENOG4107QTZ	amino acid
GWK48_RS00980	ENOG4105C5X	domain protein
GWK48_RS01020	ENOG4105DF9	Lipoate-protein, ligase
GWK48_RS01025	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GWK48_RS01070	ENOG4107R56	PP-loop domain protein
GWK48_RS01080	ENOG4105HZM	Fha domain containing protein
GWK48_RS01085	ENOG4105MEW	serine threonine protein phosphatase
GWK48_RS01105	ENOG4107QNK	)-transporter
GWK48_RS01110	ENOG4105CEP	NADH dehydrogenase
GWK48_RS01115	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
GWK48_RS01220	ENOG4105BZN	citrate synthase
GWK48_RS01235	ENOG4105D3R	alkyl hydroperoxide reductase
GWK48_RS01255	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
GWK48_RS01260	ENOG4107RBB	ABC transporter, permease
GWK48_RS01270	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GWK48_RS01295	ENOG4105BZU	Histidine kinase
GWK48_RS01310	ENOG41086B8	CoB-CoM heterodisulfide reductase
GWK48_RS01325	ENOG4107QN2	dihydrolipoyl dehydrogenase
GWK48_RS01340	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GWK48_RS01345	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
GWK48_RS01405	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
GWK48_RS01440	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GWK48_RS01450	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GWK48_RS01495	ENOG4105DCI	Phosphohydrolase
GWK48_RS01500	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
GWK48_RS01515	ENOG4105CPK	Glycosyl transferase (Group 1
GWK48_RS01540	ENOG4105C22	threonyL-tRNA synthetase
GWK48_RS01555	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
GWK48_RS01560	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
GWK48_RS01575	ENOG4108WBT	adenosyltransferase
GWK48_RS01615	ENOG4105CN5	Metallo-Beta-Lactamase
GWK48_RS01620	ENOG4105C22	threonyL-tRNA synthetase
GWK48_RS01630	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
GWK48_RS01635	ENOG4108S0S	Nucleotidyl transferase
GWK48_RS01650	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GWK48_RS01665	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
GWK48_RS01670	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
GWK48_RS01685	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
GWK48_RS01755	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GWK48_RS01770	ENOG4105K63	Thioredoxin
GWK48_RS01775	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GWK48_RS01785	ENOG4105EUJ	GTP cyclohydrolase i
GWK48_RS01790	ENOG4105DC7	peptidase M24
GWK48_RS01795	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GWK48_RS01810	ENOG4105C6T	cysteine synthase
GWK48_RS01825	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
GWK48_RS01830	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GWK48_RS01855	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
GWK48_RS01870	ENOG4105BZA	Phosphoglycerate kinase
GWK48_RS01910	ENOG4105DIW	FeS assembly protein SUFB
GWK48_RS01915	ENOG4105C3K	feS assembly ATPase SufC
GWK48_RS01935	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GWK48_RS01940	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
GWK48_RS01945	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK48_RS01950	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK48_RS01985	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
GWK48_RS01995	ENOG4105C5R	Aminotransferase
GWK48_RS02000	ENOG4108JQ1	Dehydrogenase
GWK48_RS02005	ENOG4105GRF	N-glycosylase DNA lyase
GWK48_RS02035	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
GWK48_RS02040	ENOG4105CHM	Aminotransferase
GWK48_RS02045	ENOG4105DK0	Indole-3-glycerol phosphate synthase
GWK48_RS02050	ENOG4105DDQ	anthranilate synthase
GWK48_RS02055	ENOG4105CRQ	synthase (Component I)
GWK48_RS02060	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
GWK48_RS02070	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
GWK48_RS02075	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
GWK48_RS02080	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
GWK48_RS02085	ENOG4105CZA	synthase
GWK48_RS02090	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
GWK48_RS02105	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
GWK48_RS02115	ENOG4105CFH	Aspartokinase
GWK48_RS02120	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
GWK48_RS02135	ENOG4105DBV	ornithine carbamoyltransferase
GWK48_RS02170	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
GWK48_RS02195	ENOG4105C75	arginyL-tRNA synthetase
GWK48_RS02205	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GWK48_RS02255	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
GWK48_RS02305	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
GWK48_RS02320	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GWK48_RS02330	ENOG4105VF7	tolerance protein
GWK48_RS02340	ENOG4105CB5	ATP-dependent DNA helicase recG
GWK48_RS02360	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
GWK48_RS02370	ENOG4107QRT	dEAD DEAH box helicase
GWK48_RS02385	ENOG4105E0R	Deoxyhypusine synthase
GWK48_RS02390	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK48_RS02405	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
GWK48_RS02430	ENOG4105CHR	reductase
GWK48_RS02440	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
GWK48_RS02450	ENOG4107SDT	Homocitrate synthase
GWK48_RS02500	ENOG4107QNK	)-transporter
GWK48_RS02510	ENOG4105C26	Dehydrogenase
GWK48_RS02525	ENOG4105EFA	4-hydroxyphenylacetate
GWK48_RS02530	ENOG4105ERH	Fumarylacetoacetate hydrolase
GWK48_RS02535	ENOG4108IXY	short-chain dehydrogenase reductase
GWK48_RS02545	ENOG41066FR	extracellular solute-binding protein
GWK48_RS02575	ENOG4105M7V	2'-5' rna ligase
GWK48_RS02590	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
GWK48_RS02615	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
GWK48_RS02660	ENOG4105CIF	Ornithine Cyclodeaminase
GWK48_RS02715	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
GWK48_RS02725	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
GWK48_RS02730	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
GWK48_RS02820	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
GWK48_RS02825	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
GWK48_RS02830	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
GWK48_RS02835	ENOG4105E2X	shikimate dehydrogenase
GWK48_RS02840	ENOG4105D49	3-dehydroquinate synthase
GWK48_RS02845	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
GWK48_RS02860	ENOG4108IUS	Transketolase
GWK48_RS02865	ENOG4108HHA	Transketolase
GWK48_RS02870	ENOG4105D06	uba thif-type nad fad binding protein
GWK48_RS02890	ENOG4105CBC	glutamate synthase
GWK48_RS02895	ENOG4105EYU	Glutamine amido-transferase
GWK48_RS02960	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
GWK48_RS02985	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
GWK48_RS02995	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GWK48_RS03000	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS03010	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS03020	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS03025	ENOG4105D65	subunit l
GWK48_RS03030	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS03035	ENOG4105CZA	synthase
GWK48_RS03050	ENOG4105CQ2	DNA polymerase
GWK48_RS03060	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
GWK48_RS03080	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GWK48_RS03100	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
GWK48_RS03105	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
GWK48_RS03110	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
GWK48_RS03125	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
GWK48_RS03135	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
GWK48_RS03140	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
GWK48_RS03155	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
GWK48_RS03165	ENOG4105C7K	acetolactate synthase
GWK48_RS03170	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
GWK48_RS03175	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
GWK48_RS03200	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
GWK48_RS03210	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
GWK48_RS03220	ENOG4105C8T	Leucyl-tRNA synthetase
GWK48_RS03230	ENOG4105CIH	Imidazole acetol-phosphate transaminase
GWK48_RS03235	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
GWK48_RS03240	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
GWK48_RS03245	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
GWK48_RS03250	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
GWK48_RS03260	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
GWK48_RS03270	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
GWK48_RS03275	ENOG4105VG1	fes assembly suf system protein
GWK48_RS03280	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
GWK48_RS03285	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GWK48_RS03320	ENOG4108ZRZ	Transcriptional regulator (AsnC family)
GWK48_RS03340	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
GWK48_RS03345	ENOG4105CD3	dihydroorotase
GWK48_RS03355	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
GWK48_RS03360	ENOG4105CXT	aspartate transcarbamylase
GWK48_RS03365	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
GWK48_RS03370	ENOG4107YPM	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
GWK48_RS03385	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
GWK48_RS03390	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GWK48_RS03410	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
GWK48_RS03430	ENOG4105KME	endoribonuclease L-psp
GWK48_RS03480	ENOG4105CPQ	Dehydrogenase
GWK48_RS03485	ENOG41080XP	Cbs domain
GWK48_RS03495	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
GWK48_RS03500	ENOG4105DZS	Phenylacetate-CoA ligase
GWK48_RS03515	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
GWK48_RS03525	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
GWK48_RS03540	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
GWK48_RS03595	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GWK48_RS03600	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GWK48_RS03640	ENOG41088PD	hydrolase
GWK48_RS03650	ENOG4105DJT	lAO AO transport system ATPase
GWK48_RS03665	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
GWK48_RS03670	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
GWK48_RS03675	ENOG4108V1U	phospholipid-binding protein
GWK48_RS03680	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
GWK48_RS03710	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
GWK48_RS03715	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK48_RS03720	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GWK48_RS03725	ENOG4105C8V	SAICAR synthetase
GWK48_RS03735	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
GWK48_RS03740	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
GWK48_RS03750	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
GWK48_RS03755	ENOG4105C12	Phosphoribosylglycinamide synthetase
GWK48_RS03760	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
GWK48_RS03775	ENOG4105CDH	Citrulline--aspartate ligase
GWK48_RS03780	ENOG4105CH7	arginosuccinase
GWK48_RS03785	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
GWK48_RS03790	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
GWK48_RS03795	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GWK48_RS03805	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
GWK48_RS03850	ENOG4105E39	Enoyl-CoA hydratase
GWK48_RS03855	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
GWK48_RS03860	ENOG4105D6E	homoserine dehydrogenase
GWK48_RS03870	ENOG4105MRR	Transcriptional regulator (By similarity)
GWK48_RS03875	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
GWK48_RS03885	ENOG4107YZX	Universal stress protein
GWK48_RS03890	ENOG4107QN2	dihydrolipoyl dehydrogenase
GWK48_RS03900	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GWK48_RS03935	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GWK48_RS03950	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
GWK48_RS03965	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GWK48_RS03985	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
GWK48_RS04000	ENOG4105D1Z	hydroxypyruvate reductase
GWK48_RS04005	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS04015	ENOG4107RWR	Sodium hydrogen exchanger
GWK48_RS04025	ENOG4107T5V	SNARE associated Golgi
GWK48_RS04050	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
GWK48_RS04055	ENOG4105CHR	reductase
GWK48_RS04060	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
GWK48_RS04070	ENOG4105D82	Glutamate dehydrogenase
GWK48_RS04095	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
GWK48_RS04130	ENOG4105C1G	acyl-Coa dehydrogenase
GWK48_RS04135	ENOG4105EET	magnesium chelatase
GWK48_RS04140	ENOG4105CTK	cobaltochelatase, cobn subunit
GWK48_RS04155	ENOG4105E4R	Precorrin-3B C17-methyltransferase
GWK48_RS04170	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GWK48_RS04175	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
GWK48_RS04190	ENOG41081F0	Precorrin-8x methylmutase
GWK48_RS04200	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
GWK48_RS04235	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
GWK48_RS04245	ENOG4105CSM	endonuclease III
GWK48_RS04255	ENOG4107R8N	Glycosyl transferase, family 2
GWK48_RS04260	ENOG4107QRT	dEAD DEAH box helicase
GWK48_RS04295	ENOG4105CEV	competence damage-inducible protein
GWK48_RS04300	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
GWK48_RS04315	ENOG4105E8R	UPF0173 metal-dependent hydrolase
GWK48_RS04370	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GWK48_RS04395	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
GWK48_RS04400	ENOG4105CE9	30S ribosomal protein S2
GWK48_RS04410	ENOG4108UJD	30S ribosomal protein S9
GWK48_RS04415	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
GWK48_RS04430	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
GWK48_RS04435	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
GWK48_RS04440	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK48_RS04460	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
GWK48_RS04465	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
GWK48_RS04470	ENOG4105CQ2	DNA polymerase
GWK48_RS04505	ENOG4105CRK	lysyL-tRNA synthetase
GWK48_RS04525	ENOG4105C31	Tryptophanyl-tRNA synthetase
GWK48_RS04550	ENOG4105D1F	ATP-binding protein
GWK48_RS04580	ENOG4105EYF	MMPL domain protein
GWK48_RS04600	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
GWK48_RS04610	ENOG4105CIH	Imidazole acetol-phosphate transaminase
GWK48_RS04620	ENOG4105CSH	Transporter
GWK48_RS04650	ENOG4105CSP	Major Facilitator Superfamily
GWK48_RS04665	ENOG4108J59	Extracellular solute-binding protein, family 5
GWK48_RS04675	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
GWK48_RS04685	ENOG4108JQ7	(ABC) transporter
GWK48_RS04710	ENOG4108ZJT	translation initiation factor, Sui1
GWK48_RS04725	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
GWK48_RS04755	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
GWK48_RS04760	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
GWK48_RS04775	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GWK48_RS04785	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
GWK48_RS04790	ENOG4105CPC	Aldo Keto reductase
GWK48_RS04835	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
GWK48_RS04840	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK48_RS04845	ENOG4105E3H	phosphoglycerate mutase
GWK48_RS04860	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
GWK48_RS04870	ENOG4105EM7	Selenocysteine-specific translation elongation factor
GWK48_RS04895	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
GWK48_RS04920	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
GWK48_RS04925	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GWK48_RS04930	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GWK48_RS04940	ENOG4107QRT	dEAD DEAH box helicase
GWK48_RS04960	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GWK48_RS04990	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
GWK48_RS05000	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
GWK48_RS05005	ENOG4107QK2	May be the GTPase, regulating ATP sulfurylase activity (By similarity)
GWK48_RS05010	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
GWK48_RS05035	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GWK48_RS05040	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GWK48_RS05045	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GWK48_RS05055	ENOG4105C6K	Malic enzyme
GWK48_RS05060	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
GWK48_RS05080	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
GWK48_RS05085	ENOG4105KG3	cytidine deaminase
GWK48_RS05090	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
GWK48_RS05095	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
GWK48_RS05110	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GWK48_RS05125	ENOG4105C83	adenylosuccinate lyase
GWK48_RS05145	ENOG4105DZ0	fad dependent oxidoreductase
GWK48_RS05150	ENOG4105CQC	Prephenate dehydratase
GWK48_RS05165	ENOG4105C7B	Threonine dehydratase
GWK48_RS05185	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GWK48_RS05200	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
GWK48_RS05205	ENOG4105NAU	thioesterase Superfamily protein
GWK48_RS05255	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
GWK48_RS05275	ENOG4105E66	phosphoriboisomerase A
GWK48_RS05310	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
GWK48_RS05320	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK48_RS05355	ENOG4105CUT	histidyl-tRNA synthetase
GWK48_RS05370	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
GWK48_RS05395	ENOG4107NFR	Fructose-1,6-bisphosphatase
GWK48_RS05400	ENOG4105FDK	ABC transporter
GWK48_RS05420	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
GWK48_RS05430	ENOG4105CY0	Metallo-Beta-Lactamase
GWK48_RS05435	ENOG4108MDK	Dehydrogenase
GWK48_RS05455	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
GWK48_RS05500	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
GWK48_RS05505	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
GWK48_RS05510	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
GWK48_RS05520	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
GWK48_RS05525	ENOG4105C3G	gtp-binding protein
GWK48_RS05560	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
GWK48_RS05570	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
GWK48_RS05595	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
GWK48_RS05600	ENOG4107YBY	Hydrolase
GWK48_RS05615	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
GWK48_RS05620	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
GWK48_RS05630	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
GWK48_RS05635	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
GWK48_RS05640	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
GWK48_RS05645	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWK48_RS05650	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
GWK48_RS05655	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
GWK48_RS05660	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
GWK48_RS05665	ENOG41084ME	50s ribosomal protein l29
GWK48_RS05680	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
GWK48_RS05685	ENOG41082A0	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
GWK48_RS05695	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWK48_RS05705	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
GWK48_RS05710	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
GWK48_RS05730	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
GWK48_RS05765	ENOG4105CAT	Cytidine monophosphate kinase
GWK48_RS05785	ENOG4108Z1Z	gCN5-related N-acetyltransferase
GWK48_RS05790	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
GWK48_RS05815	ENOG4108JJB	ABC transporter
GWK48_RS05820	ENOG4105EN6	Membrane
GWK48_RS05835	ENOG4105CND	Glycosyl transferase, family 2
GWK48_RS05840	ENOG4105DWF	phosphomethylpyrimidine kinase
GWK48_RS05845	ENOG4108RVA	ribokinase
GWK48_RS05865	ENOG4105CMR	udp-glucose 4-epimerase
GWK48_RS05880	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK48_RS05890	ENOG4105C2M	dna polymerase I
GWK48_RS05895	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GWK48_RS05900	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
GWK48_RS05905	ENOG4105D52	delta-aminolevulinic acid dehydratase
GWK48_RS05910	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
GWK48_RS05915	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
GWK48_RS05945	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
GWK48_RS05950	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
GWK48_RS05975	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
GWK48_RS05990	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
GWK48_RS06020	ENOG4105NBF	ammecr1 domain protein
GWK48_RS06035	ENOG4105DHP	deoxycytidine triphosphate deaminase
GWK48_RS06040	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
GWK48_RS06055	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
GWK48_RS06135	ENOG41088YS	Glycosyl transferase (Group 1
GWK48_RS06185	ENOG4105CPQ	Dehydrogenase
GWK48_RS06190	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
GWK48_RS06195	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
GWK48_RS06205	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GWK48_RS06220	ENOG4105C5S	asparaginyl-tRNA synthetase
GWK48_RS06260	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
GWK48_RS06265	ENOG4108KB0	deacetylase
GWK48_RS06270	ENOG4105C8Y	Acetylornithine aminotransferase
GWK48_RS06275	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GWK48_RS06290	ENOG4107U4Q	acetylglutamate kinase
GWK48_RS06295	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
GWK48_RS06335	ENOG41080HJ	6-phospho 3-hexuloisomerase
GWK48_RS06355	ENOG41061GT	Aldolase
GWK48_RS06375	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GWK48_RS06385	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
GWK48_RS06390	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
GWK48_RS06395	ENOG4105D0M	Protease HtpX homolog
GWK48_RS06400	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
GWK48_RS06415	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
GWK48_RS06445	ENOG4105CJ1	ABC, transporter
GWK48_RS06450	ENOG4107YZX	Universal stress protein
GWK48_RS06465	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
GWK48_RS06475	ENOG4105EUB	pirin domain protein
GWK48_RS06510	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GWK48_RS06525	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GWK48_RS06535	ENOG4105C1G	acyl-Coa dehydrogenase
GWK48_RS06545	ENOG4105C8Y	Acetylornithine aminotransferase
GWK48_RS06550	ENOG4105C1G	acyl-Coa dehydrogenase
GWK48_RS06560	ENOG4105DXD	2-methylcitrate dehydratase
GWK48_RS06565	ENOG4105CR4	methylisocitrate lyase
GWK48_RS06570	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GWK48_RS06575	ENOG4105BZN	citrate synthase
GWK48_RS06620	ENOG4105BZ9	Cytochrome C oxidase, subunit I
GWK48_RS06625	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
GWK48_RS06645	ENOG4108RAC	Rubrerythrin
GWK48_RS06700	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GWK48_RS06710	ENOG4105WGB	oxidoreductase, delta subunit
GWK48_RS06715	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GWK48_RS06720	ENOG4105DDK	oxidoreductase, beta subunit
GWK48_RS06725	ENOG41080XP	Cbs domain
GWK48_RS06805	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK48_RS06845	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GWK48_RS06870	ENOG4105CV8	reductase
GWK48_RS06875	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
GWK48_RS06885	ENOG4105CSH	Transporter
GWK48_RS06925	ENOG4108JQ7	(ABC) transporter
GWK48_RS06935	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
GWK48_RS06965	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
GWK48_RS06970	ENOG4105CQB	FAD linked oxidase domain protein
GWK48_RS06990	ENOG4105D3W	isochorismatase
GWK48_RS06995	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
GWK48_RS07005	ENOG4107QNK	)-transporter
GWK48_RS07080	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GWK48_RS07100	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
GWK48_RS07145	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK48_RS07160	ENOG4105KHC	sulfurtransferase
GWK48_RS07175	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
GWK48_RS07190	ENOG4105CI0	Citrate lyase
GWK48_RS07200	ENOG4105E4P	ATPase (AAA
GWK48_RS07210	ENOG4108UKI	Enoyl-CoA hydratase
GWK48_RS07225	ENOG4105E33	succinate dehydrogenase
GWK48_RS07240	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
GWK48_RS07245	ENOG4107GFK	fumarate
GWK48_RS07255	ENOG4105C54	Major Facilitator superfamily
GWK48_RS07265	ENOG4105CTX	dehydratase
GWK48_RS07270	ENOG4105CTX	dehydratase
GWK48_RS07275	ENOG4105DIA	mandelate racemase muconate lactonizing
GWK48_RS07280	ENOG4105DRR	Transcriptional regulator, GntR family
GWK48_RS07300	ENOG4108Z0Z	intracellular protease Pfpi family
GWK48_RS07320	ENOG4105M4B	Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity)
GWK48_RS07340	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GWK48_RS07345	ENOG4105DDK	oxidoreductase, beta subunit
GWK48_RS07385	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
GWK48_RS07400	ENOG4105CEY	Amp-dependent synthetase and ligase
GWK48_RS07405	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
GWK48_RS07470	ENOG4105E39	Enoyl-CoA hydratase
GWK48_RS07475	ENOG4105C1G	acyl-Coa dehydrogenase
GWK48_RS07480	ENOG4105CEY	Amp-dependent synthetase and ligase
GWK48_RS07495	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GWK48_RS07510	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
GWK48_RS07540	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
GWK48_RS07570	ENOG4105E39	Enoyl-CoA hydratase
GWK48_RS07575	ENOG4107Y9U	Membrane
GWK48_RS07595	ENOG4105VUC	UPF0237 protein
GWK48_RS07600	ENOG4105CAG	UPF0210 protein
GWK48_RS07605	ENOG4105CTD	carboxy-peptidase
GWK48_RS07655	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
GWK48_RS07665	ENOG4105BZJ	Electron transfer flavoprotein
GWK48_RS07685	ENOG4105VG1	fes assembly suf system protein
GWK48_RS07710	ENOG4105BZ9	Cytochrome C oxidase, subunit I
GWK48_RS07725	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
GWK48_RS07780	ENOG4105CUB	amino acid
GWK48_RS07830	ENOG4105E5W	Transporter
GWK48_RS07840	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GWK48_RS07855	ENOG4105CYW	agmatinase
GWK48_RS07895	ENOG4105DDK	oxidoreductase, beta subunit
GWK48_RS07900	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GWK48_RS07905	ENOG4105WGB	oxidoreductase, delta subunit
GWK48_RS07930	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
GWK48_RS07940	ENOG4105C4X	radical SAM domain protein
GWK48_RS07970	ENOG4105DA5	(ABC) transporter
GWK48_RS07985	ENOG4105DQU	oxidoreductase, subunit beta
GWK48_RS07990	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
GWK48_RS08025	ENOG4105DGU	Histone deacetylase
GWK48_RS08030	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
GWK48_RS08070	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
GWK48_RS08110	ENOG4108I5C	dEAD DEAH box helicase
GWK48_RS08115	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GWK48_RS08145	ENOG4105CQB	FAD linked oxidase domain protein
GWK48_RS08160	ENOG4107QJE	Chromosome Partitioning Protein
GWK48_RS08170	ENOG4107S7U	Sulfide dehydrogenase
GWK48_RS08185	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
GWK48_RS08205	ENOG4105CSH	Transporter
GWK48_RS08215	ENOG4107RQ2	Cytochrome c oxidase, subunit I
GWK48_RS08235	ENOG4105CJ1	ABC, transporter
GWK48_RS08270	ENOG4105C8T	Leucyl-tRNA synthetase
GWK48_RS08305	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
GWK48_RS08315	ENOG4105C01	Dihydroxy-acid dehydratase
GWK48_RS08320	ENOG4107V8H	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
GWK48_RS08335	ENOG4107VIJ	nudix hydrolase
GWK48_RS08370	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
GWK48_RS08395	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
GWK48_RS08410	ENOG4105DNP	FAD linked oxidase domain protein
GWK48_RS08420	ENOG4105D1F	ATP-binding protein
GWK48_RS08430	ENOG4105J7I	hydrolase
GWK48_RS08435	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
GWK48_RS08455	ENOG4108K7V	UPF0284 protein
GWK48_RS08465	ENOG4105C9B	Cysteine desulfurase
GWK48_RS08480	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
GWK48_RS08495	ENOG4105CAY	ferredoxin--nadp reductase
GWK48_RS08545	ENOG4105K63	Thioredoxin
GWK48_RS08560	ENOG4105CVJ	phosphoglycerate mutase
GWK48_RS08570	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GWK48_RS08595	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GWK48_RS08625	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
GWK48_RS08645	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
GWK48_RS08650	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK48_RS08655	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
GWK48_RS08660	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GWK48_RS08710	ENOG4105C7Z	Conserved Protein
GWK48_RS08715	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
GWK48_RS08785	ENOG4105CB5	ATP-dependent DNA helicase recG
GWK48_RS08795	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
GWK48_RS08800	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GWK48_RS08845	ENOG4108HMX	isocitrate dehydrogenase (NADP)
GWK48_RS08865	ENOG4108ZHD	aig2 family
GWK48_RS08890	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
GWK48_RS08900	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
GWK48_RS08910	ENOG4105CTB	Polyprenyl synthetase
GWK48_RS08915	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GWK48_RS08935	ENOG4105D44	asparaginase
GWK48_RS08955	ENOG4107QZT	geranylgeranyl reductase
GWK48_RS08980	ENOG4105E33	succinate dehydrogenase
GWK48_RS08995	ENOG4105C28	cystathionine
GWK48_RS09000	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
GWK48_RS09005	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
GWK48_RS09020	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
GWK48_RS09055	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GWK48_RS09075	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GWK48_RS09120	ENOG4108EHY	type IV secretion system
GWK48_RS09135	ENOG4105DK2	UPF0207 protein
GWK48_RS09140	ENOG4105DWF	phosphomethylpyrimidine kinase
GWK48_RS09160	ENOG4105EM7	Selenocysteine-specific translation elongation factor
GWK48_RS09170	ENOG4106943	Heat shock protein
GWK48_RS09185	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
GWK48_RS09200	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK48_RS09205	ENOG4105ECY	inositol monophosphatase
GWK48_RS09210	ENOG4105C3M	thioredoxin reductase
GWK48_RS09260	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GWK48_RS09290	ENOG4105CJ1	ABC, transporter
GWK48_RS09300	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
GWK48_RS09340	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GWK48_RS09375	ENOG4105C5F	glutamine synthetase
GWK48_RS09385	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
GWK48_RS09395	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
GWK48_RS09400	ENOG4108MGF	sugar kinase
GWK48_RS09405	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GWK48_RS09415	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK48_RS09420	ENOG4105PTV	Nudix Hydrolase
GWK48_RS09440	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
GWK48_RS09450	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
GWK48_RS09465	ENOG4105F7P	transcriptional regulator AsnC family
GWK48_RS09485	ENOG4105DKW	ABC transporter
GWK48_RS09490	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
GWK48_RS09495	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
GWK48_RS09525	ENOG4105DB1	molybdopterin oxidoreductase
GWK48_RS09530	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GWK48_RS09580	ENOG4105C5X	domain protein
GWK48_RS09585	ENOG4105C5R	Aminotransferase
GWK48_RS09615	ENOG4105C9U	ATP-dependent DNA helicase RecQ
GWK48_RS09625	ENOG4107QPV	Serine Threonine protein kinase
GWK48_RS09640	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GWK48_RS09645	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GWK48_RS09660	ENOG4105FCD	Major Facilitator
GWK48_RS09700	ENOG4105C54	Major Facilitator superfamily
GWK48_RS09740	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GWK48_RS09750	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS09755	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GWK48_RS09760	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GWK48_RS09785	ENOG41067TZ	transcriptional regulator, MarR family
GWK48_RS09790	ENOG4107U7N	hydantoinase B oxoprolinase
GWK48_RS09805	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
GWK48_RS09840	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
GWK48_RS09860	ENOG4105E50	uracil-dna glycosylase
GWK48_RS09865	ENOG4108ZJI	phenylacetic acid degradation protein
GWK48_RS09890	ENOG4107QTZ	amino acid
GWK48_RS09895	ENOG41067KJ	GYD family
GWK48_RS09905	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GWK48_RS09915	ENOG4105WGP	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity)
GWK48_RS09950	ENOG4105IJY	hydroxylase
GWK48_RS09955	ENOG4105EWK	phytoene
GWK48_RS09975	ENOG4105EW9	transcriptional regulator AsnC family
GWK48_RS10000	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
GWK48_RS10025	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
GWK48_RS10030	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
GWK48_RS10060	ENOG4105CQM	Urea amidohydrolase subunit alpha
GWK48_RS10070	ENOG4108WKG	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
GWK48_RS10075	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
GWK48_RS10115	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
GWK48_RS10125	ENOG4105CEU	Arginine dihydrolase
GWK48_RS10175	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GWK48_RS10245	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
GWK48_RS10285	ENOG4105DTT	CRISPR-associated helicase, cas3
GWK48_RS10315	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
GWK48_RS10330	ENOG4105D9P	serine threonine protein kinase
GWK48_RS10335	ENOG4105KRN	Transcriptional regulator, abrb family
GWK48_RS10475	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
GWK48_RS10605	ENOG4107QN2	dihydrolipoyl dehydrogenase
GWK48_RS10625	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
GWK48_RS10645	ENOG4107TSN	permease
GWK48_RS10685	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
GWK48_RS10690	ENOG4105D0M	Protease HtpX homolog
GWK48_RS10695	ENOG4105BZP	glycoside hydrolase 15-related
GWK48_RS10700	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
GWK48_RS10730	ENOG4105CPP	Dehydrogenase, E1 component
GWK48_RS10735	ENOG4107RUY	(E1 component), alpha subunit
GWK48_RS10755	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GWK48_RS10770	ENOG4105C3M	thioredoxin reductase
GWK48_RS10775	ENOG4105C10	Electron transfer flavoprotein
GWK48_RS10785	ENOG4105BZU	Histidine kinase
GWK48_RS10810	ENOG4105CYC	Transferase
GWK48_RS10815	ENOG4105C1G	acyl-Coa dehydrogenase
GWK48_RS10830	ENOG4105D2S	major facilitator superfamily
GWK48_RS10840	ENOG4105CEY	Amp-dependent synthetase and ligase
GWK48_RS10865	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
GWK48_RS10890	ENOG4105CEP	NADH dehydrogenase
GWK48_RS10965	ENOG4105DCI	Phosphohydrolase
GWK48_RS10980	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
GWK48_RS10985	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
GWK48_RS11030	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
GWK48_RS11050	ENOG4105K64	Glycosyl transferase, family 2
GWK48_RS11060	ENOG4107QRS	glycosyltransferase group 2 family protein
GWK48_RS11090	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GWK48_RS11170	ENOG4105E4P	ATPase (AAA
GWK48_RS11290	ENOG4107RGD	Major Facilitator superfamily