locus-tag	class	description
GWK48_RS00065	COG1122	ATPase activity
GWK48_RS00085	COG1028	Short-chain dehydrogenase reductase Sdr
GWK48_RS00105	COG2368	4-hydroxyphenylacetate
GWK48_RS00125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK48_RS00170	COG4555	ABC transporter
GWK48_RS00190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK48_RS00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWK48_RS00215	COG2062	phosphohistidine phosphatase, SixA
GWK48_RS00275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK48_RS00290	COG1063	alcohol dehydrogenase
GWK48_RS00310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWK48_RS00340	COG1914	H( )-stimulated, divalent metal cation uptake system
GWK48_RS00390	COG1131	(ABC) transporter
GWK48_RS00400	COG3386	PFAM SMP-30 Gluconolaconase
GWK48_RS00405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK48_RS00415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWK48_RS00420	COG0535	radical SAM domain protein
GWK48_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
GWK48_RS00450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK48_RS00455	COG0477	Major facilitator Superfamily
GWK48_RS00490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK48_RS00495	COG4948	Mandelate Racemase Muconate Lactonizing
GWK48_RS00505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK48_RS00515	COG3383	formate dehydrogenase (NAD+) activity
GWK48_RS00525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWK48_RS00560	COG3387	PFAM Glycoside hydrolase 15-related
GWK48_RS00575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK48_RS00580	COG1584	GPR1 FUN34 yaaH family protein
GWK48_RS00585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK48_RS00590	COG0556	nucleotide-excision repair
GWK48_RS00630	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK48_RS00645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK48_RS00645	COG0519	Catalyzes the synthesis of GMP from XMP
GWK48_RS00655	COG1515	deoxyribonuclease V activity
GWK48_RS00700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK48_RS00710	COG1116	anion transmembrane transporter activity
GWK48_RS00735	COG2971	BadF BadG BcrA BcrD
GWK48_RS00740	COG0717	Belongs to the dCTP deaminase family
GWK48_RS00745	COG3608	succinylglutamate desuccinylase aspartoacylase
GWK48_RS00745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWK48_RS00750	COG1720	tRNA m6t6A37 methyltransferase activity
GWK48_RS00785	COG2814	Major facilitator Superfamily
GWK48_RS00790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GWK48_RS00800	COG0708	Exodeoxyribonuclease III
GWK48_RS00820	COG1122	ATPase activity
GWK48_RS00835	COG0149	triose-phosphate isomerase activity
GWK48_RS00845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWK48_RS00850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWK48_RS00865	COG2226	methyltransferase
GWK48_RS00870	COG0516	GMP reductase activity
GWK48_RS00905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWK48_RS00925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK48_RS00960	COG0114	fumarate hydratase activity
GWK48_RS00970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK48_RS00975	COG0531	amino acid
GWK48_RS00980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK48_RS01020	COG0095	Lipoate-protein ligase
GWK48_RS01025	COG0509	glycine decarboxylation via glycine cleavage system
GWK48_RS01050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK48_RS01070	COG0037	tRNA processing
GWK48_RS01080	COG1716	ATPase activity
GWK48_RS01085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWK48_RS01105	COG2814	Major facilitator Superfamily
GWK48_RS01110	COG1252	NADH dehydrogenase
GWK48_RS01115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWK48_RS01155	COG0475	glutathione-regulated potassium exporter activity
GWK48_RS01220	COG0372	Belongs to the citrate synthase family
GWK48_RS01235	COG0450	alkyl hydroperoxide reductase
GWK48_RS01255	COG1335	isochorismatase
GWK48_RS01260	COG0577	efflux transmembrane transporter activity
GWK48_RS01270	COG1136	(ABC) transporter
GWK48_RS01295	COG0004	ammonium transporteR
GWK48_RS01310	COG2048	Heterodisulfide reductase, subunit B
GWK48_RS01325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK48_RS01340	COG0425	Belongs to the sulfur carrier protein TusA family
GWK48_RS01345	COG2210	Belongs to the sulfur carrier protein TusA family
GWK48_RS01405	COG0095	Lipoate-protein ligase
GWK48_RS01440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWK48_RS01450	COG0509	glycine decarboxylation via glycine cleavage system
GWK48_RS01495	COG1078	dGTPase activity
GWK48_RS01500	COG0813	purine-nucleoside phosphorylase activity
GWK48_RS01515	COG0438	transferase activity, transferring glycosyl groups
GWK48_RS01540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWK48_RS01555	COG0045	succinate-CoA ligase (ADP-forming) activity
GWK48_RS01575	COG2096	Adenosyltransferase
GWK48_RS01615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GWK48_RS01620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWK48_RS01630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK48_RS01635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK48_RS01650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWK48_RS01670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWK48_RS01685	COG0552	protein localization to endoplasmic reticulum
GWK48_RS01755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK48_RS01755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWK48_RS01765	COG0318	PFAM AMP-dependent synthetase and ligase
GWK48_RS01770	COG3118	belongs to the thioredoxin family
GWK48_RS01790	COG0006	proline dipeptidase activity
GWK48_RS01795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK48_RS01810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK48_RS01825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GWK48_RS01830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK48_RS01855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWK48_RS01870	COG0126	phosphoglycerate kinase activity
GWK48_RS01910	COG0719	Fe-S assembly protein
GWK48_RS01915	COG0396	ATPase activity
GWK48_RS01935	COG0509	glycine decarboxylation via glycine cleavage system
GWK48_RS01940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWK48_RS01945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK48_RS01950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK48_RS01985	COG1222	aaa ATPase
GWK48_RS01995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK48_RS02000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK48_RS02005	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
GWK48_RS02035	COG0525	valine-tRNA ligase activity
GWK48_RS02040	COG0436	Aminotransferase
GWK48_RS02045	COG0134	indole-3-glycerol-phosphate synthase activity
GWK48_RS02050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK48_RS02050	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK48_RS02055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK48_RS02060	COG0135	phosphoribosylanthranilate isomerase activity
GWK48_RS02070	COG0159	tryptophan synthase activity
GWK48_RS02075	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GWK48_RS02080	COG1254	Belongs to the acylphosphatase family
GWK48_RS02085	COG1260	myo-inositol-1-phosphate synthase
GWK48_RS02090	COG0574	Belongs to the PEP-utilizing enzyme family
GWK48_RS02090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWK48_RS02115	COG0527	aspartate kinase activity
GWK48_RS02120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWK48_RS02135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWK48_RS02170	COG0459	protein refolding
GWK48_RS02195	COG0018	arginyl-trna synthetase
GWK48_RS02205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK48_RS02220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK48_RS02255	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
GWK48_RS02305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWK48_RS02305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWK48_RS02320	COG0154	amidase activity
GWK48_RS02325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK48_RS02330	COG1324	tolerance protein
GWK48_RS02340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK48_RS02360	COG1110	DNA topoisomerase II activity
GWK48_RS02370	COG1201	RNA secondary structure unwinding
GWK48_RS02385	COG1899	peptidyl-lysine modification to peptidyl-hypusine
GWK48_RS02390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK48_RS02405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWK48_RS02410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK48_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
GWK48_RS02440	COG0528	UMP kinase activity
GWK48_RS02450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK48_RS02525	COG2368	4-hydroxyphenylacetate
GWK48_RS02530	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK48_RS02535	COG0300	oxidoreductase activity
GWK48_RS02545	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWK48_RS02575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GWK48_RS02590	COG1234	tRNA 3'-trailer cleavage
GWK48_RS02615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK48_RS02660	COG2423	ornithine cyclodeaminase activity
GWK48_RS02675	COG1185	polyribonucleotide nucleotidyltransferase activity
GWK48_RS02715	COG0438	transferase activity, transferring glycosyl groups
GWK48_RS02725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK48_RS02730	COG2222	sugar isomerase
GWK48_RS02820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWK48_RS02830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWK48_RS02835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWK48_RS02840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWK48_RS02845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GWK48_RS02860	COG3958	Transketolase
GWK48_RS02865	COG3959	Transketolase, thiamine diphosphate binding domain
GWK48_RS02870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK48_RS02890	COG0069	glutamate synthase activity
GWK48_RS02895	COG0067	glutamate synthase
GWK48_RS02960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK48_RS02965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK48_RS02985	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GWK48_RS02995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK48_RS03000	COG0649	NAD binding
GWK48_RS03005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWK48_RS03010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK48_RS03020	COG0713	ATP synthesis coupled electron transport
GWK48_RS03025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK48_RS03030	COG1007	ATP synthesis coupled electron transport
GWK48_RS03035	COG1260	myo-inositol-1-phosphate synthase
GWK48_RS03050	COG0417	DNA replication proofreading
GWK48_RS03060	COG2264	protein methyltransferase activity
GWK48_RS03080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK48_RS03100	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GWK48_RS03110	COG1394	ATPase activity, coupled to movement of substances
GWK48_RS03125	COG0442	prolyl-tRNA aminoacylation
GWK48_RS03135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GWK48_RS03140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GWK48_RS03155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWK48_RS03165	COG0028	Belongs to the TPP enzyme family
GWK48_RS03170	COG0546	phosphoglycolate phosphatase activity
GWK48_RS03175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK48_RS03185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWK48_RS03200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GWK48_RS03210	COG0037	tRNA processing
GWK48_RS03220	COG0495	leucyl-tRNA aminoacylation
GWK48_RS03230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK48_RS03235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWK48_RS03240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWK48_RS03245	COG0131	Imidazoleglycerol-phosphate dehydratase
GWK48_RS03250	COG0107	imidazoleglycerol-phosphate synthase activity
GWK48_RS03255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK48_RS03270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWK48_RS03270	COG0140	phosphoribosyl-ATP diphosphatase activity
GWK48_RS03275	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK48_RS03280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWK48_RS03285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK48_RS03320	COG1522	sequence-specific DNA binding
GWK48_RS03340	COG0167	dihydroorotate dehydrogenase activity
GWK48_RS03345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWK48_RS03355	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWK48_RS03360	COG0540	Belongs to the ATCase OTCase family
GWK48_RS03365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWK48_RS03370	COG0284	orotidine-5'-phosphate decarboxylase activity
GWK48_RS03385	COG2255	four-way junction helicase activity
GWK48_RS03390	COG0315	cyclic pyranopterin monophosphate synthase activity
GWK48_RS03410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK48_RS03480	COG1063	alcohol dehydrogenase
GWK48_RS03485	COG0517	IMP dehydrogenase activity
GWK48_RS03495	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK48_RS03500	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GWK48_RS03515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK48_RS03525	COG0297	glycogen (starch) synthase activity
GWK48_RS03540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK48_RS03595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK48_RS03600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWK48_RS03640	COG2267	carboxylic ester hydrolase activity
GWK48_RS03650	COG1703	isobutyryl-CoA mutase activity
GWK48_RS03655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK48_RS03665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWK48_RS03670	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GWK48_RS03675	COG1881	PFAM PEBP family protein
GWK48_RS03680	COG0704	Plays a role in the regulation of phosphate uptake
GWK48_RS03710	COG0602	queuosine metabolic process
GWK48_RS03715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK48_RS03720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK48_RS03720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK48_RS03725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWK48_RS03735	COG0047	phosphoribosylformylglycinamidine synthase activity
GWK48_RS03740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWK48_RS03745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWK48_RS03750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWK48_RS03760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWK48_RS03775	COG0137	argininosuccinate synthase activity
GWK48_RS03780	COG0165	Argininosuccinate lyase
GWK48_RS03785	COG0505	Belongs to the CarA family
GWK48_RS03790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK48_RS03795	COG0189	ligase activity
GWK48_RS03805	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK48_RS03850	COG1024	Enoyl-CoA hydratase
GWK48_RS03855	COG0109	protoheme IX farnesyltransferase activity
GWK48_RS03870	COG0864	Transcriptional regulator
GWK48_RS03875	COG0312	modulator of DNA gyrase
GWK48_RS03885	COG0589	response to stress
GWK48_RS03890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK48_RS03900	COG0009	L-threonylcarbamoyladenylate synthase
GWK48_RS03905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK48_RS03935	COG0402	S-adenosylhomocysteine deaminase activity
GWK48_RS03950	COG0303	'Molybdopterin
GWK48_RS03965	COG2226	methyltransferase
GWK48_RS03985	COG1321	iron dependent repressor
GWK48_RS04000	COG2379	hydroxypyruvate reductase
GWK48_RS04005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK48_RS04015	COG0475	glutathione-regulated potassium exporter activity
GWK48_RS04025	COG0586	Pfam SNARE associated Golgi protein
GWK48_RS04050	COG1573	uracil-dna glycosylase
GWK48_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
GWK48_RS04060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWK48_RS04070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK48_RS04095	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK48_RS04115	COG1607	acyl-coa hydrolase
GWK48_RS04125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK48_RS04130	COG1960	acyl-CoA dehydrogenase activity
GWK48_RS04135	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GWK48_RS04170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK48_RS04200	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GWK48_RS04235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWK48_RS04245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK48_RS04255	COG1215	transferase activity, transferring glycosyl groups
GWK48_RS04260	COG1201	RNA secondary structure unwinding
GWK48_RS04290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK48_RS04295	COG1058	Belongs to the CinA family
GWK48_RS04295	COG1546	Belongs to the CinA family
GWK48_RS04300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK48_RS04315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK48_RS04370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK48_RS04380	COG1304	FMN binding
GWK48_RS04395	COG1355	regulation of microtubule-based process
GWK48_RS04400	COG0052	Belongs to the universal ribosomal protein uS2 family
GWK48_RS04410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWK48_RS04415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWK48_RS04430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWK48_RS04435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWK48_RS04440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK48_RS04460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK48_RS04470	COG0417	DNA replication proofreading
GWK48_RS04505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWK48_RS04525	COG0180	Tryptophanyl-tRNA synthetase
GWK48_RS04550	COG0489	protein tyrosine kinase activity
GWK48_RS04600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWK48_RS04610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK48_RS04620	COG0477	Major facilitator Superfamily
GWK48_RS04650	COG2271	Major facilitator Superfamily
GWK48_RS04665	COG4166	transmembrane transport
GWK48_RS04670	COG0601	transmembrane transport
GWK48_RS04680	COG0444	Belongs to the ABC transporter superfamily
GWK48_RS04685	COG4608	Belongs to the ABC transporter superfamily
GWK48_RS04710	COG0023	Translation Initiation Factor
GWK48_RS04725	COG0423	glycine-tRNA ligase activity
GWK48_RS04755	COG0163	prenyltransferase activity
GWK48_RS04760	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GWK48_RS04775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWK48_RS04785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK48_RS04790	COG0667	Aldo Keto reductase
GWK48_RS04835	COG1110	DNA topoisomerase II activity
GWK48_RS04840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK48_RS04845	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GWK48_RS04860	COG0557	exoribonuclease II activity
GWK48_RS04895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWK48_RS04920	COG2813	Specifically methylates the guanine in position
GWK48_RS04925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK48_RS04930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK48_RS04940	COG1201	RNA secondary structure unwinding
GWK48_RS04960	COG0402	S-adenosylhomocysteine deaminase activity
GWK48_RS04970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWK48_RS04980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK48_RS04980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK48_RS04990	COG1797	cobyrinic acid a,c-diamide synthase activity
GWK48_RS05000	COG0051	transcription antitermination factor activity, RNA binding
GWK48_RS05005	COG2895	sulfate adenylyltransferase (ATP) activity
GWK48_RS05010	COG0049	tRNA binding
GWK48_RS05035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWK48_RS05040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWK48_RS05045	COG0085	RNA polymerase activity
GWK48_RS05055	COG0281	malic enzyme
GWK48_RS05060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWK48_RS05080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWK48_RS05085	COG0295	cytidine deaminase activity
GWK48_RS05090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK48_RS05095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK48_RS05105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK48_RS05105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK48_RS05110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK48_RS05125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK48_RS05145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GWK48_RS05150	COG0077	Prephenate dehydratase
GWK48_RS05150	COG1605	Chorismate mutase
GWK48_RS05165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK48_RS05185	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWK48_RS05185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK48_RS05200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWK48_RS05255	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GWK48_RS05275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWK48_RS05310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWK48_RS05320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK48_RS05355	COG0124	histidyl-tRNA synthetase
GWK48_RS05395	COG1980	fructose-bisphosphate aldolase activity
GWK48_RS05400	COG1121	(ABC) transporter
GWK48_RS05420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWK48_RS05430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWK48_RS05435	COG0371	Dehydrogenase
GWK48_RS05455	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWK48_RS05500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK48_RS05510	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWK48_RS05520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWK48_RS05525	COG0012	GTP binding
GWK48_RS05560	COG1185	polyribonucleotide nucleotidyltransferase activity
GWK48_RS05570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWK48_RS05595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWK48_RS05600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK48_RS05615	COG0473	3-isopropylmalate dehydrogenase activity
GWK48_RS05620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK48_RS05630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWK48_RS05635	COG0088	Forms part of the polypeptide exit tunnel
GWK48_RS05640	COG0089	rRNA binding
GWK48_RS05645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWK48_RS05650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWK48_RS05655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWK48_RS05660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWK48_RS05665	COG0255	Belongs to the universal ribosomal protein uL29 family
GWK48_RS05680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWK48_RS05685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWK48_RS05695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWK48_RS05705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWK48_RS05710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWK48_RS05730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWK48_RS05785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWK48_RS05790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK48_RS05815	COG1122	ATPase activity
GWK48_RS05820	COG2860	membrane
GWK48_RS05835	COG1215	transferase activity, transferring glycosyl groups
GWK48_RS05840	COG0352	thiamine-phosphate diphosphorylase activity
GWK48_RS05840	COG0351	phosphomethylpyrimidine kinase
GWK48_RS05845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK48_RS05865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK48_RS05880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK48_RS05890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK48_RS05890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK48_RS05895	COG1648	precorrin-2 dehydrogenase activity
GWK48_RS05895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK48_RS05900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWK48_RS05905	COG0113	porphobilinogen synthase activity
GWK48_RS05910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK48_RS05915	COG0181	hydroxymethylbilane synthase activity
GWK48_RS05945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK48_RS05945	COG2022	thiamine diphosphate biosynthetic process
GWK48_RS05950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK48_RS05975	COG0504	CTP synthase activity
GWK48_RS05990	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GWK48_RS06020	COG2078	PFAM AMMECR1 domain protein
GWK48_RS06035	COG0717	Belongs to the dCTP deaminase family
GWK48_RS06040	COG1793	dna ligase
GWK48_RS06055	COG0439	Biotin carboxylase
GWK48_RS06135	COG0438	transferase activity, transferring glycosyl groups
GWK48_RS06185	COG1063	alcohol dehydrogenase
GWK48_RS06190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GWK48_RS06195	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GWK48_RS06205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK48_RS06205	COG0519	Catalyzes the synthesis of GMP from XMP
GWK48_RS06220	COG0017	Asparaginyl-tRNA synthetase
GWK48_RS06260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK48_RS06265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK48_RS06270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK48_RS06275	COG0189	ligase activity
GWK48_RS06290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWK48_RS06295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWK48_RS06335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWK48_RS06355	COG1830	Aldolase
GWK48_RS06375	COG0516	GMP reductase activity
GWK48_RS06375	COG0517	IMP dehydrogenase activity
GWK48_RS06385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWK48_RS06390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK48_RS06395	COG0501	Belongs to the peptidase M48B family
GWK48_RS06400	COG0405	Gamma-glutamyltransferase
GWK48_RS06415	COG1444	tRNA N-acetyltransferase activity
GWK48_RS06445	COG1131	(ABC) transporter
GWK48_RS06450	COG0589	response to stress
GWK48_RS06465	COG1444	tRNA N-acetyltransferase activity
GWK48_RS06475	COG1741	Belongs to the pirin family
GWK48_RS06525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK48_RS06535	COG1960	acyl-CoA dehydrogenase activity
GWK48_RS06545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK48_RS06550	COG1960	acyl-CoA dehydrogenase activity
GWK48_RS06560	COG2079	MmgE PrpD family protein
GWK48_RS06565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWK48_RS06570	COG0517	IMP dehydrogenase activity
GWK48_RS06570	COG0516	GMP reductase activity
GWK48_RS06575	COG0372	Belongs to the citrate synthase family
GWK48_RS06620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK48_RS06645	COG1592	Rubrerythrin
GWK48_RS06700	COG0437	4 iron, 4 sulfur cluster binding
GWK48_RS06710	COG1144	Oxidoreductase
GWK48_RS06715	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS06720	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS06725	COG0517	IMP dehydrogenase activity
GWK48_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK48_RS06845	COG3842	ATPase activity
GWK48_RS06870	COG0656	L-ascorbic acid biosynthetic process
GWK48_RS06875	COG0039	L-malate dehydrogenase activity
GWK48_RS06885	COG0477	Major facilitator Superfamily
GWK48_RS06925	COG4608	Belongs to the ABC transporter superfamily
GWK48_RS06930	COG0444	Belongs to the ABC transporter superfamily
GWK48_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK48_RS06940	COG0601	transmembrane transport
GWK48_RS06960	COG0604	alcohol dehydrogenase
GWK48_RS06970	COG0277	FAD linked oxidase domain protein
GWK48_RS06990	COG1335	isochorismatase
GWK48_RS06995	COG0574	Belongs to the PEP-utilizing enzyme family
GWK48_RS06995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWK48_RS07005	COG2814	Major facilitator Superfamily
GWK48_RS07080	COG0425	Belongs to the sulfur carrier protein TusA family
GWK48_RS07100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK48_RS07135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWK48_RS07145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK48_RS07160	COG2897	thiosulfate sulfurtransferase activity
GWK48_RS07175	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK48_RS07190	COG2301	Belongs to the HpcH HpaI aldolase family
GWK48_RS07200	COG1373	ATPase (AAA superfamily
GWK48_RS07210	COG1024	Enoyl-CoA hydratase
GWK48_RS07225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK48_RS07240	COG1053	succinate dehydrogenase
GWK48_RS07245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK48_RS07255	COG2271	Major facilitator Superfamily
GWK48_RS07265	COG2721	sulfolactate sulfo-lyase activity
GWK48_RS07270	COG2721	sulfolactate sulfo-lyase activity
GWK48_RS07280	COG1802	Transcriptional regulator
GWK48_RS07340	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS07345	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS07365	COG1522	sequence-specific DNA binding
GWK48_RS07400	COG0318	PFAM AMP-dependent synthetase and ligase
GWK48_RS07405	COG4946	Tricorn protease homolog
GWK48_RS07405	COG1506	peptidase
GWK48_RS07405	COG0823	Involved in the tonB-independent uptake of proteins
GWK48_RS07470	COG1024	Enoyl-CoA hydratase
GWK48_RS07475	COG1960	acyl-CoA dehydrogenase activity
GWK48_RS07480	COG0318	PFAM AMP-dependent synthetase and ligase
GWK48_RS07495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK48_RS07510	COG0243	molybdopterin cofactor binding
GWK48_RS07570	COG1024	Enoyl-CoA hydratase
GWK48_RS07575	COG0697	spore germination
GWK48_RS07595	COG3830	Belongs to the UPF0237 family
GWK48_RS07600	COG2848	UPF0210 protein
GWK48_RS07605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWK48_RS07655	COG0644	oxidoreductase
GWK48_RS07665	COG2086	electron transfer activity
GWK48_RS07685	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK48_RS07710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK48_RS07725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWK48_RS07730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK48_RS07780	COG0531	amino acid
GWK48_RS07830	COG2211	Major facilitator Superfamily
GWK48_RS07840	COG2814	Major facilitator Superfamily
GWK48_RS07845	COG1473	amidohydrolase
GWK48_RS07895	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS07900	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS07905	COG1144	Oxidoreductase
GWK48_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK48_RS07940	COG0641	radical SAM
GWK48_RS07970	COG1131	(ABC) transporter
GWK48_RS07985	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS07990	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK48_RS07990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWK48_RS08020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWK48_RS08020	COG0617	tRNA 3'-terminal CCA addition
GWK48_RS08020	COG0517	IMP dehydrogenase activity
GWK48_RS08030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWK48_RS08110	COG1205	dead DEAH box helicase
GWK48_RS08110	COG1111	helicase
GWK48_RS08115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWK48_RS08145	COG0277	FAD linked oxidase domain protein
GWK48_RS08160	COG1192	Involved in chromosome partitioning
GWK48_RS08170	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK48_RS08185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWK48_RS08205	COG0477	Major facilitator Superfamily
GWK48_RS08215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK48_RS08235	COG1131	(ABC) transporter
GWK48_RS08270	COG0495	leucyl-tRNA aminoacylation
GWK48_RS08320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK48_RS08335	COG0494	nUDIX hydrolase
GWK48_RS08370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWK48_RS08395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWK48_RS08410	COG0277	FAD linked oxidase domain protein
GWK48_RS08420	COG0489	protein tyrosine kinase activity
GWK48_RS08430	COG0561	phosphatase activity
GWK48_RS08435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWK48_RS08455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GWK48_RS08480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK48_RS08495	COG0492	ferredoxin-NADP+ reductase activity
GWK48_RS08560	COG0406	alpha-ribazole phosphatase activity
GWK48_RS08570	COG0517	IMP dehydrogenase activity
GWK48_RS08570	COG0516	GMP reductase activity
GWK48_RS08595	COG0517	IMP dehydrogenase activity
GWK48_RS08595	COG0516	GMP reductase activity
GWK48_RS08625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK48_RS08645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK48_RS08645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWK48_RS08650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK48_RS08655	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWK48_RS08660	COG0154	amidase activity
GWK48_RS08710	COG1331	Highly conserved protein containing a thioredoxin domain
GWK48_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
GWK48_RS08785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK48_RS08795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK48_RS08800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK48_RS08840	COG2226	methyltransferase
GWK48_RS08845	COG0538	isocitrate dehydrogenase activity
GWK48_RS08860	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWK48_RS08865	COG2105	PFAM AIG2 family protein
GWK48_RS08900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GWK48_RS08910	COG0142	geranyltranstransferase activity
GWK48_RS08915	COG0189	ligase activity
GWK48_RS08915	COG0569	domain protein
GWK48_RS08925	COG0644	oxidoreductase
GWK48_RS08935	COG1446	asparaginase
GWK48_RS08955	COG0644	oxidoreductase
GWK48_RS08970	COG0647	UMP catabolic process
GWK48_RS08980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK48_RS09000	COG0083	homoserine kinase activity
GWK48_RS09005	COG0303	'Molybdopterin
GWK48_RS09020	COG0714	Associated with various cellular activities
GWK48_RS09025	COG2304	oxidoreductase activity
GWK48_RS09055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWK48_RS09075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK48_RS09080	COG0183	Belongs to the thiolase family
GWK48_RS09120	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GWK48_RS09140	COG0351	phosphomethylpyrimidine kinase
GWK48_RS09140	COG0352	thiamine-phosphate diphosphorylase activity
GWK48_RS09170	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK48_RS09175	COG0346	lactoylglutathione lyase activity
GWK48_RS09180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK48_RS09180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK48_RS09200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK48_RS09210	COG0492	ferredoxin-NADP+ reductase activity
GWK48_RS09260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK48_RS09290	COG1131	(ABC) transporter
GWK48_RS09300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWK48_RS09375	COG0174	glutamine synthetase
GWK48_RS09385	COG0430	RNA-3'-phosphate cyclase activity
GWK48_RS09395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK48_RS09400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK48_RS09415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK48_RS09440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK48_RS09450	COG0805	protein transport
GWK48_RS09465	COG1522	sequence-specific DNA binding
GWK48_RS09480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWK48_RS09485	COG1119	ATPase activity
GWK48_RS09490	COG4139	cobalamin transport
GWK48_RS09495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK48_RS09525	COG0243	molybdopterin cofactor binding
GWK48_RS09530	COG0437	4 iron, 4 sulfur cluster binding
GWK48_RS09580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK48_RS09585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK48_RS09610	COG0475	glutathione-regulated potassium exporter activity
GWK48_RS09615	COG0551	DNA topoisomerase type I activity
GWK48_RS09615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK48_RS09625	COG0515	serine threonine protein kinase
GWK48_RS09640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK48_RS09645	COG0066	3-isopropylmalate dehydratase activity
GWK48_RS09665	COG2814	Major facilitator Superfamily
GWK48_RS09700	COG2271	Major facilitator Superfamily
GWK48_RS09740	COG0651	ATP synthesis coupled electron transport
GWK48_RS09750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK48_RS09755	COG0649	NAD binding
GWK48_RS09760	COG0651	ATP synthesis coupled electron transport
GWK48_RS09780	COG2814	Major facilitator Superfamily
GWK48_RS09785	COG1846	Transcriptional regulator
GWK48_RS09790	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GWK48_RS09805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GWK48_RS09840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK48_RS09860	COG1573	uracil-dna glycosylase
GWK48_RS09865	COG2050	protein possibly involved in aromatic compounds catabolism
GWK48_RS09890	COG0531	amino acid
GWK48_RS09895	COG4274	PFAM GYD family protein
GWK48_RS09905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK48_RS09915	COG0824	Thioesterase
GWK48_RS09945	COG1562	ergosterol biosynthetic process
GWK48_RS10000	COG1401	restriction endodeoxyribonuclease activity
GWK48_RS10025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GWK48_RS10030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWK48_RS10035	COG0477	Major facilitator Superfamily
GWK48_RS10060	COG0804	urea catabolic process
GWK48_RS10075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWK48_RS10115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK48_RS10125	COG2235	arginine
GWK48_RS10175	COG2226	methyltransferase
GWK48_RS10215	COG4454	pyrroloquinoline quinone binding
GWK48_RS10235	COG0455	bacterial-type flagellum organization
GWK48_RS10245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWK48_RS10285	COG1203	CRISPR-associated helicase, Cas3
GWK48_RS10315	COG1518	maintenance of DNA repeat elements
GWK48_RS10330	COG2815	serine threonine protein kinase
GWK48_RS10330	COG0515	serine threonine protein kinase
GWK48_RS10335	COG2002	toxin-antitoxin pair type II binding
GWK48_RS10475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GWK48_RS10605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK48_RS10625	COG3383	formate dehydrogenase (NAD+) activity
GWK48_RS10645	COG0730	response to heat
GWK48_RS10655	COG2814	Major facilitator Superfamily
GWK48_RS10685	COG1968	undecaprenyl-diphosphatase activity
GWK48_RS10690	COG0501	Belongs to the peptidase M48B family
GWK48_RS10695	COG3387	PFAM Glycoside hydrolase 15-related
GWK48_RS10700	COG1073	alpha beta
GWK48_RS10700	COG2226	methyltransferase
GWK48_RS10730	COG0022	dehydrogenase e1 component
GWK48_RS10735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK48_RS10750	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GWK48_RS10755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWK48_RS10770	COG0492	ferredoxin-NADP+ reductase activity
GWK48_RS10775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWK48_RS10785	COG0004	ammonium transporteR
GWK48_RS10810	COG0427	acetyl-CoA hydrolase
GWK48_RS10815	COG1960	acyl-CoA dehydrogenase activity
GWK48_RS10830	COG2271	Major facilitator Superfamily
GWK48_RS10840	COG0318	PFAM AMP-dependent synthetase and ligase
GWK48_RS10865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWK48_RS10890	COG1252	NADH dehydrogenase
GWK48_RS10965	COG1078	dGTPase activity
GWK48_RS10975	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GWK48_RS11030	COG2264	protein methyltransferase activity
GWK48_RS11050	COG1215	transferase activity, transferring glycosyl groups
GWK48_RS11060	COG1216	Glycosyl transferase, family 2
GWK48_RS11090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWK48_RS11095	COG2192	nodulation
GWK48_RS11170	COG1373	ATPase (AAA superfamily
GWK48_RS11290	COG2814	Major facilitator Superfamily
GWK48_RS11320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B