locus-tag	class	description
BK007_RS00020	COG2814	Major facilitator Superfamily
BK007_RS00030	COG1378	Sugar-specific transcriptional regulator TrmB
BK007_RS00055	COG1873	PFAM PRC-barrel domain
BK007_RS00060	COG0393	Putative heavy-metal-binding
BK007_RS00080	COG0737	Belongs to the 5'-nucleotidase family
BK007_RS00090	COG0864	Transcriptional regulator
BK007_RS00165	COG0069	glutamate synthase activity
BK007_RS00175	COG2151	metal-sulfur cluster biosynthetic enzyme
BK007_RS00195	COG0318	PFAM AMP-dependent synthetase and ligase
BK007_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BK007_RS00235	COG0047	phosphoribosylformylglycinamidine synthase activity
BK007_RS00270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BK007_RS00290	COG0084	hydrolase, TatD family'
BK007_RS00295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK007_RS00360	COG1454	alcohol dehydrogenase
BK007_RS00375	COG1011	Hydrolase
BK007_RS00385	COG1309	transcriptional regulator
BK007_RS00420	COG0174	glutamine synthetase
BK007_RS00440	COG1429	ligase activity, forming nitrogen-metal bonds
BK007_RS00445	COG1429	ligase activity, forming nitrogen-metal bonds
BK007_RS00450	COG1429	ligase activity, forming nitrogen-metal bonds
BK007_RS00465	COG1122	ATPase activity
BK007_RS00485	COG1918	ferrous iron import across plasma membrane
BK007_RS00485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BK007_RS00495	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BK007_RS00495	COG1918	ferrous iron import across plasma membrane
BK007_RS00530	COG0310	cobalt ion transport
BK007_RS00545	COG0310	cobalt ion transport
BK007_RS00570	COG1408	metallophosphoesterase
BK007_RS00580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BK007_RS00630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BK007_RS00640	COG1185	polyribonucleotide nucleotidyltransferase activity
BK007_RS00675	COG0534	Mate efflux family protein
BK007_RS00695	COG0577	efflux transmembrane transporter activity
BK007_RS00695	COG1136	(ABC) transporter
BK007_RS00700	COG1136	(ABC) transporter
BK007_RS00715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK007_RS00720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK007_RS00725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK007_RS00735	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
BK007_RS00740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BK007_RS00745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BK007_RS00785	COG0375	protein maturation
BK007_RS00820	COG1067	ATP-dependent peptidase activity
BK007_RS00820	COG0470	DNA polymerase III
BK007_RS00825	COG1492	cobalamin metabolic process
BK007_RS00830	COG0569	domain protein
BK007_RS00835	COG0589	response to stress
BK007_RS00850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK007_RS00850	COG0517	IMP dehydrogenase activity
BK007_RS00850	COG0617	tRNA 3'-terminal CCA addition
BK007_RS00855	COG0864	Transcriptional regulator
BK007_RS00860	COG2264	protein methyltransferase activity
BK007_RS00875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK007_RS00880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BK007_RS00885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK007_RS00910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK007_RS00945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK007_RS00970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BK007_RS00980	COG0517	IMP dehydrogenase activity
BK007_RS00990	COG0482	sulfurtransferase activity
BK007_RS01000	COG1418	mRNA catabolic process
BK007_RS01015	COG2878	Part of a membrane complex involved in electron transport
BK007_RS01025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK007_RS01030	COG1809	phosphosulfolactate synthase activity
BK007_RS01040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BK007_RS01055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BK007_RS01060	COG0081	regulation of translation
BK007_RS01075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BK007_RS01085	COG1618	nucleotide phosphatase activity, acting on free nucleotides
BK007_RS01120	COG0312	modulator of DNA gyrase
BK007_RS01125	COG0561	phosphatase activity
BK007_RS01130	COG0409	Hydrogenase expression formation protein
BK007_RS01135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK007_RS01200	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BK007_RS01200	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BK007_RS01205	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BK007_RS01225	COG1476	TRANSCRIPTIONal
BK007_RS01245	COG2197	response regulator
BK007_RS01270	COG2226	methyltransferase
BK007_RS01295	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BK007_RS01300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK007_RS01315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BK007_RS01320	COG0602	queuosine metabolic process
BK007_RS01345	COG1268	BioY protein
BK007_RS01365	COG1695	Transcriptional regulator
BK007_RS01370	COG4974	Belongs to the 'phage' integrase family
BK007_RS01375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK007_RS01395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BK007_RS01420	COG4895	conserved protein (DUF2196)
BK007_RS01445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BK007_RS01460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BK007_RS01475	COG4591	ABC-type transport system involved in lipoprotein release permease component
BK007_RS01480	COG0577	efflux transmembrane transporter activity
BK007_RS01480	COG1136	(ABC) transporter
BK007_RS01485	COG0393	Putative heavy-metal-binding
BK007_RS01490	COG0393	Putative heavy-metal-binding
BK007_RS01505	COG0528	UMP kinase activity
BK007_RS01510	COG0659	secondary active sulfate transmembrane transporter activity
BK007_RS01525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BK007_RS01530	COG0673	inositol 2-dehydrogenase activity
BK007_RS01535	COG0181	hydroxymethylbilane synthase activity
BK007_RS01545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BK007_RS01565	COG0010	Belongs to the arginase family
BK007_RS01575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BK007_RS01610	COG3920	Histidine kinase
BK007_RS01615	COG2226	methyltransferase
BK007_RS01625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK007_RS01645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK007_RS01685	COG1185	polyribonucleotide nucleotidyltransferase activity
BK007_RS01730	COG5002	protein histidine kinase activity
BK007_RS01770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BK007_RS01775	COG0826	peptidase U32
BK007_RS01780	COG0617	tRNA 3'-terminal CCA addition
BK007_RS01780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK007_RS01780	COG0517	IMP dehydrogenase activity
BK007_RS01785	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BK007_RS01795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK007_RS01815	COG1088	dTDP-glucose 4,6-dehydratase activity
BK007_RS01825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BK007_RS01865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BK007_RS01870	COG1525	nuclease
BK007_RS01895	COG0419	ATPase involved in DNA repair
BK007_RS01925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK007_RS01930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BK007_RS01955	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BK007_RS01960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK007_RS01970	COG0287	Prephenate dehydrogenase
BK007_RS02030	COG0864	Transcriptional regulator
BK007_RS02035	COG0175	sulfate reduction
BK007_RS02085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BK007_RS02115	COG0210	DNA helicase
BK007_RS02120	COG3593	DNA synthesis involved in DNA repair
BK007_RS02155	COG1131	(ABC) transporter
BK007_RS02175	COG0298	carbon dioxide binding
BK007_RS02190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BK007_RS02190	COG0512	Glutamine amidotransferase of anthranilate synthase
BK007_RS02200	COG0135	phosphoribosylanthranilate isomerase activity
BK007_RS02205	COG0133	tryptophan synthase activity
BK007_RS02210	COG0159	tryptophan synthase activity
BK007_RS02215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BK007_RS02230	COG1266	CAAX protease self-immunity
BK007_RS02240	COG2264	protein methyltransferase activity
BK007_RS02265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BK007_RS02270	COG1073	alpha beta
BK007_RS02275	COG2226	methyltransferase
BK007_RS02295	COG3548	integral membrane protein
BK007_RS02310	COG0778	Nitroreductase
BK007_RS02350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BK007_RS02360	COG0798	PFAM Bile acid sodium symporter
BK007_RS02365	COG0640	Transcriptional regulator
BK007_RS02370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK007_RS02410	COG0471	metal ion transport
BK007_RS02460	COG0628	permease
BK007_RS02470	COG1309	transcriptional regulator
BK007_RS02475	COG0656	L-ascorbic acid biosynthetic process
BK007_RS02495	COG0534	Mate efflux family protein
BK007_RS02545	COG0051	transcription antitermination factor activity, RNA binding
BK007_RS02550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BK007_RS02555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK007_RS02560	COG0049	tRNA binding
BK007_RS02580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK007_RS02585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK007_RS02590	COG0085	RNA polymerase activity
BK007_RS02595	COG0085	RNA polymerase activity
BK007_RS02630	COG0126	phosphoglycerate kinase activity
BK007_RS02670	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK007_RS02675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK007_RS02675	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK007_RS02705	COG1183	phosphatidylcholine synthase activity
BK007_RS02710	COG0688	phosphatidylethanolamine metabolic process
BK007_RS02745	COG0778	Nitroreductase
BK007_RS02745	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
BK007_RS02750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BK007_RS02765	COG4172	Belongs to the ABC transporter superfamily
BK007_RS02775	COG1648	precorrin-2 dehydrogenase activity
BK007_RS02775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BK007_RS02780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BK007_RS02790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK007_RS02800	COG3920	Histidine kinase
BK007_RS02815	COG1151	hydroxylamine reductase activity
BK007_RS02850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK007_RS02865	COG0708	Exodeoxyribonuclease III
BK007_RS02870	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK007_RS02900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK007_RS02900	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK007_RS02910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK007_RS02940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK007_RS02950	COG1216	Glycosyl transferase, family 2
BK007_RS02975	COG1793	dna ligase
BK007_RS02980	COG3920	Histidine kinase
BK007_RS03000	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BK007_RS03005	COG0516	GMP reductase activity
BK007_RS03005	COG0517	IMP dehydrogenase activity
BK007_RS03040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BK007_RS03060	COG3585	molybdate ion transport
BK007_RS03075	COG3842	ATPase activity
BK007_RS03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK007_RS03105	COG1120	ATPase activity
BK007_RS03120	COG0347	Belongs to the P(II) protein family
BK007_RS03130	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BK007_RS03150	COG1433	Dinitrogenase iron-molybdenum cofactor
BK007_RS03150	COG0535	radical SAM domain protein
BK007_RS03160	COG0243	molybdopterin cofactor binding
BK007_RS03170	COG0243	molybdopterin cofactor binding
BK007_RS03180	COG1229	Formylmethanofuran dehydrogenase subunit A
BK007_RS03215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BK007_RS03220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BK007_RS03235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BK007_RS03265	COG1473	amidohydrolase
BK007_RS03280	COG2116	formate transmembrane transporter activity
BK007_RS03285	COG3383	formate dehydrogenase (NAD+) activity
BK007_RS03305	COG0288	reversible hydration of carbon dioxide
BK007_RS03315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BK007_RS03320	COG0148	phosphopyruvate hydratase activity
BK007_RS03325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BK007_RS03340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK007_RS03340	COG0517	IMP dehydrogenase activity
BK007_RS03340	COG0617	tRNA 3'-terminal CCA addition
BK007_RS03345	COG1328	CTP reductase activity
BK007_RS03345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BK007_RS03360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BK007_RS03410	COG0402	S-adenosylhomocysteine deaminase activity
BK007_RS03415	COG2217	Heavy metal translocating P-type atpase
BK007_RS03425	COG0585	pseudouridine synthase activity
BK007_RS03430	COG0107	imidazoleglycerol-phosphate synthase activity
BK007_RS03445	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BK007_RS03460	COG0402	S-adenosylhomocysteine deaminase activity
BK007_RS03465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BK007_RS03470	COG0179	Fumarylacetoacetate (FAA) hydrolase
BK007_RS03480	COG0495	leucyl-tRNA aminoacylation
BK007_RS03490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BK007_RS03530	COG0012	GTP binding
BK007_RS03535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BK007_RS03540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK007_RS03565	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BK007_RS03570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BK007_RS03575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BK007_RS03615	COG1515	deoxyribonuclease V activity
BK007_RS03625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BK007_RS03625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BK007_RS03630	COG1492	cobalamin metabolic process
BK007_RS03635	COG0154	amidase activity
BK007_RS03660	COG3548	integral membrane protein
BK007_RS03685	COG1131	(ABC) transporter
BK007_RS03705	COG2197	response regulator
BK007_RS03710	COG0745	RESPONSE REGULATOR receiver
BK007_RS03715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK007_RS03735	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BK007_RS03740	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
BK007_RS03755	COG0131	Imidazoleglycerol-phosphate dehydratase
BK007_RS03760	COG3548	integral membrane protein
BK007_RS03795	COG1797	cobyrinic acid a,c-diamide synthase activity
BK007_RS03815	COG1192	Involved in chromosome partitioning
BK007_RS03830	COG3174	membrane
BK007_RS03835	COG0129	dihydroxy-acid dehydratase activity
BK007_RS03845	COG0018	arginyl-trna synthetase
BK007_RS03850	COG1309	transcriptional regulator
BK007_RS03855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BK007_RS03865	COG0151	Belongs to the GarS family
BK007_RS03870	COG0028	Belongs to the TPP enzyme family
BK007_RS03875	COG0440	acetolactate synthase activity
BK007_RS03880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BK007_RS03895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BK007_RS03915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK007_RS03920	COG1968	undecaprenyl-diphosphatase activity
BK007_RS03950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK007_RS04015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BK007_RS04040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BK007_RS04045	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BK007_RS04050	COG0540	Belongs to the ATCase OTCase family
BK007_RS04100	COG3189	MarR family transcriptional regulator
BK007_RS04110	COG0019	diaminopimelate decarboxylase activity
BK007_RS04115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BK007_RS04125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BK007_RS04180	COG0427	acetyl-CoA hydrolase
BK007_RS04190	COG0281	malic enzyme
BK007_RS04325	COG0107	imidazoleglycerol-phosphate synthase activity
BK007_RS04345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BK007_RS04365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BK007_RS04375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK007_RS04385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK007_RS04390	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BK007_RS04390	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BK007_RS04395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BK007_RS04415	COG0426	domain, Protein
BK007_RS04420	COG1773	rubredoxin
BK007_RS04420	COG1592	Rubrerythrin
BK007_RS04450	COG1131	(ABC) transporter
BK007_RS04465	COG1131	(ABC) transporter
BK007_RS04470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BK007_RS04480	COG1136	(ABC) transporter
BK007_RS04480	COG0577	efflux transmembrane transporter activity
BK007_RS04485	COG1136	(ABC) transporter
BK007_RS04500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BK007_RS04505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BK007_RS04510	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
BK007_RS04540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BK007_RS04550	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BK007_RS04565	COG1846	Transcriptional regulator
BK007_RS04570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BK007_RS04575	COG0066	3-isopropylmalate dehydratase activity
BK007_RS04580	COG0473	3-isopropylmalate dehydrogenase activity
BK007_RS04585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK007_RS04590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BK007_RS04605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BK007_RS04615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BK007_RS04620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BK007_RS04710	COG2890	protein-(glutamine-N5) methyltransferase activity
BK007_RS04720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BK007_RS04745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BK007_RS04810	COG1185	polyribonucleotide nucleotidyltransferase activity
BK007_RS04825	COG1379	DNA repair
BK007_RS04855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BK007_RS04860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK007_RS04885	COG0024	Methionine aminopeptidase
BK007_RS04945	COG0484	heat shock protein binding
BK007_RS04955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BK007_RS04970	COG1691	(AIR) carboxylase
BK007_RS04985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BK007_RS04990	COG4106	trans-aconitate 2-methyltransferase activity
BK007_RS05015	COG1335	isochorismatase
BK007_RS05040	COG1131	(ABC) transporter
BK007_RS05075	COG1309	transcriptional regulator
BK007_RS05105	COG2226	methyltransferase
BK007_RS05115	COG1695	Transcriptional regulator
BK007_RS05135	COG1136	(ABC) transporter
BK007_RS05140	COG0577	efflux transmembrane transporter activity
BK007_RS05145	COG1136	(ABC) transporter
BK007_RS05145	COG0577	efflux transmembrane transporter activity
BK007_RS05170	COG1136	(ABC) transporter
BK007_RS05170	COG0577	efflux transmembrane transporter activity
BK007_RS05215	COG2813	Specifically methylates the guanine in position
BK007_RS05220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BK007_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK007_RS05260	COG0330	HflC and HflK could
BK007_RS05275	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
BK007_RS05285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BK007_RS05285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BK007_RS05310	COG1309	transcriptional regulator
BK007_RS05375	COG1007	ATP synthesis coupled electron transport
BK007_RS05400	COG1140	nitrate reductase beta subunit
BK007_RS05415	COG0649	NAD binding
BK007_RS05430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK007_RS05490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BK007_RS05495	COG1309	transcriptional regulator
BK007_RS05505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BK007_RS05520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BK007_RS05570	COG0602	queuosine metabolic process
BK007_RS05575	COG0517	IMP dehydrogenase activity
BK007_RS05580	COG0617	tRNA 3'-terminal CCA addition
BK007_RS05580	COG0517	IMP dehydrogenase activity
BK007_RS05580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK007_RS05585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK007_RS05585	COG0617	tRNA 3'-terminal CCA addition
BK007_RS05585	COG0517	IMP dehydrogenase activity
BK007_RS05595	COG0516	GMP reductase activity
BK007_RS05610	COG1605	Chorismate mutase
BK007_RS05610	COG0077	Prephenate dehydratase
BK007_RS05630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BK007_RS05715	COG2226	methyltransferase
BK007_RS05720	COG1131	(ABC) transporter
BK007_RS05760	COG0167	dihydroorotate dehydrogenase activity
BK007_RS05765	COG0543	2 iron, 2 sulfur cluster binding
BK007_RS05820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK007_RS05830	COG0517	IMP dehydrogenase activity
BK007_RS05835	COG0140	phosphoribosyl-ATP diphosphatase activity
BK007_RS05845	COG0667	Aldo Keto reductase
BK007_RS05855	COG0778	Nitroreductase
BK007_RS05870	COG0028	Belongs to the TPP enzyme family
BK007_RS05870	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
BK007_RS05880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BK007_RS05885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BK007_RS05890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BK007_RS05900	COG2264	protein methyltransferase activity
BK007_RS05910	COG2197	response regulator
BK007_RS05920	COG0784	Response regulator, receiver
BK007_RS05930	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BK007_RS05940	COG1469	GTP cyclohydrolase I activity
BK007_RS05950	COG0123	including yeast histone deacetylase and acetoin utilization protein
BK007_RS05955	COG1522	sequence-specific DNA binding
BK007_RS05975	COG0069	glutamate synthase activity
BK007_RS05995	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
BK007_RS06005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK007_RS06015	COG0037	tRNA processing
BK007_RS06035	COG2045	Belongs to the ComB family
BK007_RS06040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK007_RS06055	COG1408	metallophosphoesterase
BK007_RS06060	COG1918	ferrous iron import across plasma membrane
BK007_RS06060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BK007_RS06070	COG1342	Belongs to the UPF0251 family
BK007_RS06080	COG0489	protein tyrosine kinase activity
BK007_RS06095	COG2894	cell division
BK007_RS06105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK007_RS06175	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
BK007_RS06205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BK007_RS06220	COG0396	ATPase activity
BK007_RS06235	COG3259	Nickel-dependent hydrogenase
BK007_RS06255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BK007_RS06260	COG1323	Belongs to the UPF0348 family
BK007_RS06265	COG1047	Peptidyl-prolyl cis-trans
BK007_RS06270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BK007_RS06285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BK007_RS06295	COG0076	glutamate decarboxylase activity
BK007_RS06305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK007_RS06310	COG2133	pyrroloquinoline quinone binding
BK007_RS06320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BK007_RS06340	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BK007_RS06345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BK007_RS06365	COG1260	myo-inositol-1-phosphate synthase
BK007_RS06390	COG0753	catalase activity
BK007_RS06400	COG2832	Protein of unknown function (DUF454)
BK007_RS06435	COG4172	Belongs to the ABC transporter superfamily
BK007_RS06440	COG1342	Belongs to the UPF0251 family
BK007_RS06450	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BK007_RS06460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK007_RS06500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BK007_RS06540	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BK007_RS06565	COG1269	ATP hydrolysis coupled proton transport
BK007_RS06610	COG0393	Putative heavy-metal-binding
BK007_RS06615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BK007_RS06630	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BK007_RS06640	COG0072	phenylalanine-tRNA ligase activity
BK007_RS06640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK007_RS06645	COG1012	belongs to the aldehyde dehydrogenase family
BK007_RS06670	COG1994	Peptidase M50
BK007_RS06760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK007_RS06815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BK007_RS06820	COG0573	inorganic phosphate transmembrane transporter activity
BK007_RS06825	COG0581	inorganic phosphate transmembrane transporter activity
BK007_RS06830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK007_RS06835	COG0704	Plays a role in the regulation of phosphate uptake
BK007_RS06865	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK007_RS06870	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK007_RS06875	COG1144	Oxidoreductase
BK007_RS06880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK007_RS06885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BK007_RS06890	COG0037	tRNA processing
BK007_RS06915	COG0785	Cytochrome C biogenesis protein
BK007_RS06930	COG1323	Belongs to the UPF0348 family
BK007_RS06990	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BK007_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK007_RS07005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BK007_RS07025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BK007_RS07035	COG0826	peptidase U32
BK007_RS07045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BK007_RS07060	COG0693	protein deglycase activity
BK007_RS07090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK007_RS07095	COG0170	dolichyl monophosphate biosynthetic process
BK007_RS07100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK007_RS07110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BK007_RS07135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BK007_RS07155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK007_RS07160	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BK007_RS07165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BK007_RS07220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BK007_RS07230	COG0584	glycerophosphoryl diester phosphodiesterase
BK007_RS07235	COG0756	dUTP diphosphatase activity
BK007_RS07240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK007_RS07245	COG0028	Belongs to the TPP enzyme family
BK007_RS07250	COG1032	radical SAM domain protein
BK007_RS07255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BK007_RS07275	COG1216	Glycosyl transferase, family 2
BK007_RS07275	COG0438	transferase activity, transferring glycosyl groups
BK007_RS07295	COG1216	Glycosyl transferase, family 2
BK007_RS07300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BK007_RS07340	COG1316	TRANSCRIPTIONal
BK007_RS07360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK007_RS07390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BK007_RS07405	COG1216	Glycosyl transferase, family 2
BK007_RS07415	COG2154	pterin-4-alpha-carbinolamine dehydratase
BK007_RS07430	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BK007_RS07440	COG0347	Belongs to the P(II) protein family
BK007_RS07445	COG0004	ammonium transporteR
BK007_RS07450	COG0347	Belongs to the P(II) protein family
BK007_RS07455	COG0004	ammonium transporteR
BK007_RS07460	COG0069	glutamate synthase activity
BK007_RS07475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BK007_RS07480	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BK007_RS07495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BK007_RS07505	COG0039	L-malate dehydrogenase activity
BK007_RS07515	COG0473	3-isopropylmalate dehydrogenase activity
BK007_RS07520	COG1980	fructose-bisphosphate aldolase activity
BK007_RS07525	COG2197	response regulator
BK007_RS07550	COG0009	L-threonylcarbamoyladenylate synthase
BK007_RS07570	COG1129	ABC transporter
BK007_RS07580	COG1881	PFAM PEBP family protein
BK007_RS07585	COG0482	sulfurtransferase activity
BK007_RS07595	COG0165	Argininosuccinate lyase
BK007_RS07620	COG0539	negative regulation of cytoplasmic translation
BK007_RS07625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BK007_RS07645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK007_RS07650	COG0105	UTP biosynthetic process
BK007_RS07675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BK007_RS07685	COG0180	Tryptophanyl-tRNA synthetase
BK007_RS07695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BK007_RS07710	COG1082	Xylose isomerase domain protein TIM barrel
BK007_RS07720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BK007_RS07730	COG1458	PINc domain ribonuclease
BK007_RS07740	COG0745	RESPONSE REGULATOR receiver
BK007_RS07775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK007_RS07785	COG0710	3-dehydroquinate dehydratase activity
BK007_RS07795	COG0501	Belongs to the peptidase M48B family
BK007_RS07835	COG2255	four-way junction helicase activity
BK007_RS07840	COG2255	four-way junction helicase activity
BK007_RS07850	COG3259	Nickel-dependent hydrogenase
BK007_RS07855	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BK007_RS07875	COG0668	transmembrane transport
BK007_RS07880	COG1234	tRNA 3'-trailer cleavage
BK007_RS07900	COG1827	regulation of RNA biosynthetic process
BK007_RS07925	COG2894	cell division
BK007_RS07930	COG2894	cell division
BK007_RS07935	COG0804	urea catabolic process
BK007_RS07945	COG0717	Belongs to the dCTP deaminase family
BK007_RS07955	COG0247	lactate metabolic process
BK007_RS07985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BK007_RS07995	COG4145	pantothenate transmembrane transporter activity
BK007_RS08005	COG0454	-acetyltransferase
BK007_RS08025	COG3279	Response regulator of the LytR AlgR family
BK007_RS08035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BK007_RS08045	COG3920	Histidine kinase
BK007_RS08075	COG2172	sigma factor antagonist activity
BK007_RS08100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK007_RS08120	COG0521	Mo-molybdopterin cofactor biosynthetic process
BK007_RS08135	COG2144	transferase activity, transferring acyl groups
BK007_RS08170	COG1433	Dinitrogenase iron-molybdenum cofactor
BK007_RS08170	COG0535	radical SAM domain protein
BK007_RS08175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BK007_RS08210	COG1131	(ABC) transporter
BK007_RS08220	COG2226	methyltransferase
BK007_RS08230	COG0247	lactate metabolic process
BK007_RS08230	COG2181	nitrate reductase activity
BK007_RS08235	COG2048	Heterodisulfide reductase, subunit B
BK007_RS08260	COG0516	GMP reductase activity
BK007_RS08260	COG0517	IMP dehydrogenase activity
BK007_RS08270	COG0426	domain, Protein
BK007_RS08275	COG0306	phosphate transporter
BK007_RS08290	COG1253	flavin adenine dinucleotide binding
BK007_RS08305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK007_RS08315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK007_RS08320	COG0436	Aminotransferase
BK007_RS08335	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BK007_RS08355	COG0297	glycogen (starch) synthase activity
BK007_RS08355	COG0438	transferase activity, transferring glycosyl groups
BK007_RS08370	COG1086	Polysaccharide biosynthesis protein
BK007_RS08375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK007_RS08385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BK007_RS08395	COG2089	acid synthase
BK007_RS08405	COG0463	Glycosyl transferase, family 2
BK007_RS08440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BK007_RS08450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BK007_RS08455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK007_RS08550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK007_RS08565	COG0346	lactoylglutathione lyase activity
BK007_RS08580	COG0477	Major facilitator Superfamily
BK007_RS08585	COG0628	permease
BK007_RS08600	COG3920	Histidine kinase
BK007_RS08605	COG3920	Histidine kinase
BK007_RS08625	COG0430	RNA-3'-phosphate cyclase activity
BK007_RS08635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BK007_RS08635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BK007_RS08640	COG0439	Biotin carboxylase
BK007_RS08645	COG2264	protein methyltransferase activity
BK007_RS08655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BK007_RS08660	COG0088	Forms part of the polypeptide exit tunnel
BK007_RS08665	COG0089	rRNA binding
BK007_RS08670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BK007_RS08675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BK007_RS08680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BK007_RS08690	COG0255	Belongs to the universal ribosomal protein uL29 family
BK007_RS08695	COG0023	Translation Initiation Factor
BK007_RS08705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BK007_RS08710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BK007_RS08715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BK007_RS08725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BK007_RS08735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BK007_RS08740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BK007_RS08760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BK007_RS08775	COG0201	protein transport
BK007_RS08795	COG0563	adenylate kinase activity
BK007_RS08815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BK007_RS08820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK007_RS08825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BK007_RS08835	COG0200	Binds to the 23S rRNA
BK007_RS08845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BK007_RS08870	COG0052	Belongs to the universal ribosomal protein uS2 family
BK007_RS08880	COG1355	regulation of microtubule-based process
BK007_RS08890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BK007_RS08895	COG1304	FMN binding
BK007_RS08900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK007_RS08905	COG0142	geranyltranstransferase activity
BK007_RS08910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK007_RS08930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BK007_RS08995	COG2770	Histidine kinase
BK007_RS08995	COG2208	phosphoserine phosphatase activity
BK007_RS09000	COG2172	sigma factor antagonist activity
BK007_RS09005	COG1366	Belongs to the anti-sigma-factor antagonist family
BK007_RS09010	COG0534	Mate efflux family protein
BK007_RS09060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK007_RS09065	COG1215	transferase activity, transferring glycosyl groups
BK007_RS09105	COG3920	Histidine kinase
BK007_RS09125	COG1592	Rubrerythrin
BK007_RS09130	COG2033	superoxide reductase activity
BK007_RS09140	COG1185	polyribonucleotide nucleotidyltransferase activity
BK007_RS09150	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BK007_RS09175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BK007_RS09185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BK007_RS09200	COG0072	phenylalanine-tRNA ligase activity
BK007_RS09215	COG0432	Pfam Uncharacterised protein family UPF0047
BK007_RS09220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BK007_RS09225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK007_RS09240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BK007_RS09250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BK007_RS09275	COG0640	Transcriptional regulator
BK007_RS09290	COG4999	Histidine kinase
BK007_RS09290	COG3850	Histidine kinase
BK007_RS09290	COG3437	response regulator, receiver
BK007_RS09290	COG2205	protein histidine kinase activity
BK007_RS09295	COG0784	Response regulator, receiver
BK007_RS09300	COG4251	negative regulation of phosphorylation
BK007_RS09360	COG4191	Histidine kinase
BK007_RS09375	COG1331	Highly conserved protein containing a thioredoxin domain
BK007_RS09380	COG0864	Transcriptional regulator
BK007_RS09385	COG0803	Belongs to the bacterial solute-binding protein 9 family
BK007_RS09390	COG1121	(ABC) transporter
BK007_RS09395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK007_RS09410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BK007_RS09420	COG0371	Dehydrogenase
BK007_RS09425	COG0442	prolyl-tRNA aminoacylation
BK007_RS09440	COG0351	phosphomethylpyrimidine kinase
BK007_RS09450	COG2226	methyltransferase
BK007_RS09460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BK007_RS09470	COG0450	alkyl hydroperoxide reductase
BK007_RS09480	COG1773	rubredoxin
BK007_RS09490	COG1773	rubredoxin
BK007_RS09510	COG0589	response to stress
BK007_RS09520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK007_RS09535	COG1078	dGTPase activity
BK007_RS09540	COG0163	prenyltransferase activity
BK007_RS09545	COG2264	protein methyltransferase activity
BK007_RS09560	COG0746	molybdenum cofactor guanylyltransferase activity
BK007_RS09565	COG0516	GMP reductase activity
BK007_RS09565	COG0517	IMP dehydrogenase activity
BK007_RS09590	COG1216	Glycosyl transferase, family 2
BK007_RS09595	COG1215	transferase activity, transferring glycosyl groups
BK007_RS09615	COG0463	Glycosyl transferase, family 2
BK007_RS09625	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BK007_RS09625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BK007_RS09630	COG0343	queuine tRNA-ribosyltransferase activity
BK007_RS09660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BK007_RS09665	COG1091	dTDP-4-dehydrorhamnose reductase activity
BK007_RS09720	COG3335	DDE superfamily endonuclease
BK007_RS09725	COG0436	Aminotransferase
BK007_RS09730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK007_RS09750	COG3481	metal-dependent phosphohydrolase, HD sub domain
BK007_RS09775	COG3773	Cell wall hydrolase
BK007_RS09775	COG3409	Peptidoglycan-binding domain 1 protein
BK007_RS09810	COG3920	Histidine kinase
BK007_RS09830	COG2814	Major facilitator Superfamily
BK007_RS09855	COG0501	Belongs to the peptidase M48B family
BK007_RS09860	COG1704	LemA family
BK007_RS09870	COG1704	LemA family
BK007_RS09900	COG0745	RESPONSE REGULATOR receiver
BK007_RS09935	COG0210	DNA helicase
BK007_RS10020	COG0693	protein deglycase activity
BK007_RS10035	COG2226	methyltransferase
BK007_RS10055	COG0864	Transcriptional regulator
BK007_RS10060	COG1397	ADP-ribosylglycohydrolase
BK007_RS10080	COG0864	Transcriptional regulator
BK007_RS10095	COG2154	pterin-4-alpha-carbinolamine dehydratase
BK007_RS10135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BK007_RS10190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BK007_RS10200	COG1111	helicase
BK007_RS10200	COG1205	dead DEAH box helicase
BK007_RS10205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK007_RS10210	COG0758	DNA mediated transformation
BK007_RS10275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK007_RS10285	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BK007_RS10330	COG3773	Cell wall hydrolase
BK007_RS10330	COG3409	Peptidoglycan-binding domain 1 protein
BK007_RS10390	COG0571	ribonuclease III activity
BK007_RS10405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BK007_RS10405	COG0426	domain, Protein
BK007_RS10450	COG2816	NAD+ diphosphatase activity
BK007_RS10455	COG3263	regulation of cellular component size
BK007_RS10460	COG2197	response regulator
BK007_RS10475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK007_RS10520	COG3920	Histidine kinase
BK007_RS10535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK007_RS10565	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BK007_RS10570	COG0501	Belongs to the peptidase M48B family
BK007_RS10585	COG2814	Major facilitator Superfamily
BK007_RS10620	COG0477	Major facilitator Superfamily
BK007_RS10635	COG1584	GPR1 FUN34 yaaH family protein
BK007_RS10640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK007_RS10650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BK007_RS10650	COG1918	ferrous iron import across plasma membrane
BK007_RS10655	COG1321	iron dependent repressor
BK007_RS10660	COG0459	protein refolding
BK007_RS10675	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
BK007_RS10685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BK007_RS10690	COG0017	Asparaginyl-tRNA synthetase
BK007_RS10695	COG2081	HI0933 family
BK007_RS10720	COG1830	Aldolase
BK007_RS10725	COG1465	3-dehydroquinate synthase
BK007_RS10740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BK007_RS10760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK007_RS10760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK007_RS10775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK007_RS10855	COG1215	transferase activity, transferring glycosyl groups
BK007_RS10860	COG0438	transferase activity, transferring glycosyl groups
BK007_RS10865	COG0438	transferase activity, transferring glycosyl groups
BK007_RS10870	COG0438	transferase activity, transferring glycosyl groups
BK007_RS10890	COG0297	glycogen (starch) synthase activity
BK007_RS10895	COG1215	transferase activity, transferring glycosyl groups
BK007_RS10915	COG2226	methyltransferase
BK007_RS10975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK007_RS10995	COG0492	ferredoxin-NADP+ reductase activity
BK007_RS11045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BK007_RS11065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK007_RS11070	COG0649	NAD binding
BK007_RS11090	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
BK007_RS11095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK007_RS11115	COG0301	tRNA thio-modification
BK007_RS11125	COG0822	iron-sulfur transferase activity
BK007_RS11145	COG0215	cysteine-tRNA ligase activity
BK007_RS11160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BK007_RS11170	COG0367	asparagine synthase
BK007_RS11185	COG0460	homoserine dehydrogenase
BK007_RS11190	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BK007_RS11205	COG0504	CTP synthase activity
BK007_RS11285	COG1363	Peptidase, m42
BK007_RS11295	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BK007_RS11300	COG0745	RESPONSE REGULATOR receiver
BK007_RS11315	COG0556	nucleotide-excision repair
BK007_RS11325	COG4251	negative regulation of phosphorylation
BK007_RS11330	COG0784	Response regulator, receiver
BK007_RS11370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BK007_RS11390	COG0113	porphobilinogen synthase activity
BK007_RS11405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BK007_RS11420	COG1201	RNA secondary structure unwinding
BK007_RS11460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BK007_RS11475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BK007_RS11480	COG1032	radical SAM domain protein
BK007_RS11490	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BK007_RS11495	COG1518	maintenance of DNA repeat elements
BK007_RS11525	COG1203	CRISPR-associated helicase, Cas3
BK007_RS11575	COG1796	DNA polymerase
BK007_RS11575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BK007_RS11585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK007_RS11595	COG2050	protein possibly involved in aromatic compounds catabolism
BK007_RS11595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BK007_RS11635	COG0459	protein refolding
BK007_RS11655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BK007_RS11660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BK007_RS11685	COG0616	signal peptide processing
BK007_RS11695	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BK007_RS11700	COG0438	transferase activity, transferring glycosyl groups
BK007_RS11700	COG0297	glycogen (starch) synthase activity
BK007_RS11725	COG1215	transferase activity, transferring glycosyl groups
BK007_RS11795	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BK007_RS11805	COG1592	Rubrerythrin
BK007_RS11810	COG3920	Histidine kinase
BK007_RS11855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK007_RS11860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BK007_RS11870	COG0066	3-isopropylmalate dehydratase activity
BK007_RS11880	COG0535	radical SAM domain protein
BK007_RS11920	COG0101	tRNA pseudouridine synthase activity
BK007_RS11940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BK007_RS11940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BK007_RS11945	COG1305	Transglutaminase-like
BK007_RS11965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK007_RS11975	COG2078	PFAM AMMECR1 domain protein
BK007_RS11980	COG0312	modulator of DNA gyrase
BK007_RS11985	COG0517	IMP dehydrogenase activity
BK007_RS11985	COG0516	GMP reductase activity
BK007_RS12010	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK007_RS12025	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BK007_RS12030	COG0310	cobalt ion transport
BK007_RS12035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK007_RS12045	COG0284	orotidine-5'-phosphate decarboxylase activity
BK007_RS12060	COG0516	GMP reductase activity
BK007_RS12090	COG0693	protein deglycase activity
BK007_RS12130	COG1131	(ABC) transporter