locus-tag	class	description
MJ_RS00005	COG0436	Aminotransferase
MJ_RS00035	COG0243	molybdopterin cofactor binding
MJ_RS00040	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
MJ_RS00055	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MJ_RS00095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MJ_RS00100	COG0252	asparaginase activity
MJ_RS00125	COG0430	RNA-3'-phosphate cyclase activity
MJ_RS00130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MJ_RS00130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MJ_RS00150	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MJ_RS00155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MJ_RS00170	COG1372	Participates in initiation and elongation during chromosome replication
MJ_RS00170	COG0719	Fe-S assembly protein
MJ_RS00175	COG0396	ATPase activity
MJ_RS00180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MJ_RS00215	COG1379	DNA repair
MJ_RS00220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MJ_RS00230	COG2890	protein-(glutamine-N5) methyltransferase activity
MJ_RS00255	COG0076	glutamate decarboxylase activity
MJ_RS00270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MJ_RS00295	COG0004	ammonium transporteR
MJ_RS00300	COG0347	Belongs to the P(II) protein family
MJ_RS00305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MJ_RS00335	COG0175	sulfate reduction
MJ_RS00350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MJ_RS00395	COG0714	Associated with various cellular activities
MJ_RS00430	COG2890	protein-(glutamine-N5) methyltransferase activity
MJ_RS00435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MJ_RS00445	COG1120	ATPase activity
MJ_RS00450	COG0826	peptidase U32
MJ_RS00460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MJ_RS00500	COG0516	GMP reductase activity
MJ_RS00500	COG0517	IMP dehydrogenase activity
MJ_RS00505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MJ_RS00510	COG0163	prenyltransferase activity
MJ_RS00525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MJ_RS00530	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MJ_RS00550	COG0469	pyruvate kinase activity
MJ_RS00555	COG0483	inositol monophosphate 1-phosphatase activity
MJ_RS00560	COG4095	Psort location CytoplasmicMembrane, score
MJ_RS00565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MJ_RS00605	COG1185	polyribonucleotide nucleotidyltransferase activity
MJ_RS00620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MJ_RS00640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MJ_RS00645	COG2361	Protein of unknown function DUF86
MJ_RS00655	COG2361	Protein of unknown function DUF86
MJ_RS00695	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MJ_RS00715	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MJ_RS00725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MJ_RS00750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MJ_RS00775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MJ_RS00785	COG1522	sequence-specific DNA binding
MJ_RS00805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MJ_RS00845	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MJ_RS00850	COG0440	acetolactate synthase activity
MJ_RS00855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MJ_RS00870	COG1691	(AIR) carboxylase
MJ_RS00890	COG2894	cell division
MJ_RS00895	COG0668	transmembrane transport
MJ_RS00900	COG1793	dna ligase
MJ_RS00905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MJ_RS00925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MJ_RS00930	COG0088	Forms part of the polypeptide exit tunnel
MJ_RS00935	COG0089	rRNA binding
MJ_RS00940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MJ_RS00945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MJ_RS00965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MJ_RS00975	COG2239	Acts as a magnesium transporter
MJ_RS00985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MJ_RS00990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MJ_RS00995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MJ_RS01010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MJ_RS01015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MJ_RS01035	COG0148	phosphopyruvate hydratase activity
MJ_RS01050	COG0586	Pfam SNARE associated Golgi protein
MJ_RS01060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MJ_RS01065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MJ_RS01105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MJ_RS01120	COG0375	protein maturation
MJ_RS01130	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MJ_RS01135	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MJ_RS01145	COG1527	subunit (C
MJ_RS01155	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MJ_RS01160	COG1269	ATP hydrolysis coupled proton transport
MJ_RS01185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MJ_RS01205	COG0423	glycine-tRNA ligase activity
MJ_RS01220	COG0312	modulator of DNA gyrase
MJ_RS01225	COG0148	phosphopyruvate hydratase activity
MJ_RS01235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MJ_RS01245	COG0351	phosphomethylpyrimidine kinase
MJ_RS01255	COG0018	arginyl-trna synthetase
MJ_RS01285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MJ_RS01295	COG0077	Prephenate dehydratase
MJ_RS01295	COG1605	Chorismate mutase
MJ_RS01340	COG1809	phosphosulfolactate synthase activity
MJ_RS01350	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MJ_RS01350	COG0028	Belongs to the TPP enzyme family
MJ_RS01360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MJ_RS01380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MJ_RS01395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MJ_RS01400	COG1013	pyruvate-flavodoxin oxidoreductase activity
MJ_RS01405	COG0674	pyruvate-flavodoxin oxidoreductase activity
MJ_RS01410	COG1144	Oxidoreductase
MJ_RS01415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MJ_RS01435	COG1476	TRANSCRIPTIONal
MJ_RS01450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MJ_RS01465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MJ_RS01465	COG0674	pyruvate-flavodoxin oxidoreductase activity
MJ_RS01470	COG0028	Belongs to the TPP enzyme family
MJ_RS01475	COG1047	Peptidyl-prolyl cis-trans
MJ_RS01480	COG0109	protoheme IX farnesyltransferase activity
MJ_RS01500	COG0489	protein tyrosine kinase activity
MJ_RS01540	COG0552	protein localization to endoplasmic reticulum
MJ_RS01550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MJ_RS01555	COG1201	RNA secondary structure unwinding
MJ_RS01560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MJ_RS01565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MJ_RS01580	COG1980	fructose-bisphosphate aldolase activity
MJ_RS01585	COG0583	DNA-binding transcription factor activity
MJ_RS01590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MJ_RS01595	COG0140	phosphoribosyl-ATP diphosphatase activity
MJ_RS01595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MJ_RS01600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MJ_RS01630	COG0010	Belongs to the arginase family
MJ_RS01650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MJ_RS01660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MJ_RS01675	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MJ_RS01685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MJ_RS01695	COG0051	transcription antitermination factor activity, RNA binding
MJ_RS01700	COG2895	sulfate adenylyltransferase (ATP) activity
MJ_RS01710	COG2252	PERMEase
MJ_RS01935	COG4974	Belongs to the 'phage' integrase family
MJ_RS01950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MJ_RS01965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MJ_RS01970	COG0671	phosphoesterase, PA-phosphatase related
MJ_RS01980	COG1203	CRISPR-associated helicase, Cas3
MJ_RS01990	COG1518	maintenance of DNA repeat elements
MJ_RS02030	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MJ_RS02045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MJ_RS02060	COG1994	Peptidase M50
MJ_RS02060	COG0517	IMP dehydrogenase activity
MJ_RS02085	COG1185	polyribonucleotide nucleotidyltransferase activity
MJ_RS02115	COG1830	Aldolase
MJ_RS02130	COG1355	regulation of microtubule-based process
MJ_RS02155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MJ_RS02175	COG0107	imidazoleglycerol-phosphate synthase activity
MJ_RS02185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MJ_RS02230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MJ_RS02270	COG0717	Belongs to the dCTP deaminase family
MJ_RS02310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MJ_RS02310	COG0116	Belongs to the methyltransferase superfamily
MJ_RS02325	COG0730	response to heat
MJ_RS02335	COG1185	polyribonucleotide nucleotidyltransferase activity
MJ_RS02350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MJ_RS02380	COG0135	phosphoribosylanthranilate isomerase activity
MJ_RS02395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MJ_RS02405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MJ_RS02410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MJ_RS02430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MJ_RS02435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MJ_RS02440	COG0255	Belongs to the universal ribosomal protein uL29 family
MJ_RS02455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MJ_RS02460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MJ_RS02480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MJ_RS02485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MJ_RS02490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MJ_RS02520	COG0200	Binds to the 23S rRNA
MJ_RS02565	COG0037	tRNA processing
MJ_RS02570	COG1242	4 iron, 4 sulfur cluster binding
MJ_RS02590	COG0039	L-malate dehydrogenase activity
MJ_RS02605	COG0157	Belongs to the NadC ModD family
MJ_RS02615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MJ_RS02635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MJ_RS02650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MJ_RS02655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MJ_RS02670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MJ_RS02690	COG0081	regulation of translation
MJ_RS02700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MJ_RS02735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MJ_RS02830	COG0426	domain, Protein
MJ_RS02835	COG0123	including yeast histone deacetylase and acetoin utilization protein
MJ_RS02855	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MJ_RS02865	COG1051	belongs to the nudix hydrolase family
MJ_RS02865	COG1056	cytidyltransferase-related domain
MJ_RS02870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MJ_RS02870	COG0574	Belongs to the PEP-utilizing enzyme family
MJ_RS02875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MJ_RS02880	COG0463	Glycosyl transferase, family 2
MJ_RS02890	COG2894	cell division
MJ_RS02900	COG0864	Transcriptional regulator
MJ_RS02920	COG1254	Belongs to the acylphosphatase family
MJ_RS02930	COG1363	Peptidase, m42
MJ_RS02950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MJ_RS02970	COG0270	DNA (cytosine-5-)-methyltransferase activity
MJ_RS02975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MJ_RS03000	COG0181	hydroxymethylbilane synthase activity
MJ_RS03015	COG0457	Tetratricopeptide repeat
MJ_RS03040	COG0589	response to stress
MJ_RS03050	COG2894	cell division
MJ_RS03090	COG0585	pseudouridine synthase activity
MJ_RS03175	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MJ_RS03185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MJ_RS03210	COG1227	inorganic diphosphatase activity
MJ_RS03215	COG0531	amino acid
MJ_RS03225	COG0457	Tetratricopeptide repeat
MJ_RS03225	COG0705	Rhomboid family
MJ_RS03230	COG1994	Peptidase M50
MJ_RS03240	COG1605	Chorismate mutase
MJ_RS03240	COG0287	Prephenate dehydrogenase
MJ_RS03245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MJ_RS03255	COG1394	ATPase activity, coupled to movement of substances
MJ_RS03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MJ_RS03265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MJ_RS03270	COG1872	DUF167
MJ_RS03275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MJ_RS03290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MJ_RS03335	COG0306	phosphate transporter
MJ_RS03350	COG0495	leucyl-tRNA aminoacylation
MJ_RS03355	COG1509	lysine 2,3-aminomutase activity
MJ_RS03365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MJ_RS03370	COG1605	Chorismate mutase
MJ_RS03370	COG0077	Prephenate dehydratase
MJ_RS03375	COG2226	methyltransferase
MJ_RS03390	COG0126	phosphoglycerate kinase activity
MJ_RS03400	COG0113	porphobilinogen synthase activity
MJ_RS03405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MJ_RS03420	COG1730	sister chromatid segregation
MJ_RS03425	COG0446	pyridine nucleotide-disulphide oxidoreductase
MJ_RS03435	COG0616	signal peptide processing
MJ_RS03440	COG1534	Rna-binding protein
MJ_RS03445	COG0517	IMP dehydrogenase activity
MJ_RS03450	COG0167	dihydroorotate dehydrogenase activity
MJ_RS03460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MJ_RS03480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MJ_RS03515	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MJ_RS03525	COG0513	Belongs to the DEAD box helicase family
MJ_RS03535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MJ_RS03540	COG0471	metal ion transport
MJ_RS03565	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MJ_RS03575	COG3958	Transketolase
MJ_RS03580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MJ_RS03585	COG3959	Transketolase, thiamine diphosphate binding domain
MJ_RS03600	COG0436	Aminotransferase
MJ_RS03675	COG0131	Imidazoleglycerol-phosphate dehydratase
MJ_RS03680	COG0402	S-adenosylhomocysteine deaminase activity
MJ_RS03700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MJ_RS03810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MJ_RS03830	COG0314	molybdopterin synthase activity
MJ_RS03845	COG0473	3-isopropylmalate dehydrogenase activity
MJ_RS03850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MJ_RS03860	COG1522	sequence-specific DNA binding
MJ_RS03865	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
MJ_RS03875	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MJ_RS03885	COG1151	hydroxylamine reductase activity
MJ_RS03895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MJ_RS03900	COG0431	NADPH-dependent FMN reductase
MJ_RS03905	COG0426	domain, Protein
MJ_RS03915	COG1592	Rubrerythrin
MJ_RS03920	COG1773	rubredoxin
MJ_RS03925	COG0450	alkyl hydroperoxide reductase
MJ_RS03945	COG1773	rubredoxin
MJ_RS03950	COG2033	superoxide reductase activity
MJ_RS03960	COG2048	Heterodisulfide reductase, subunit B
MJ_RS03975	COG1592	Rubrerythrin
MJ_RS03975	COG1773	rubredoxin
MJ_RS03985	COG0426	domain, Protein
MJ_RS03995	COG0348	domain, Protein
MJ_RS04055	COG0425	Belongs to the sulfur carrier protein TusA family
MJ_RS04060	COG0084	hydrolase, TatD family'
MJ_RS04090	COG0864	Transcriptional regulator
MJ_RS04095	COG0778	Nitroreductase
MJ_RS04095	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MJ_RS04135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MJ_RS04255	COG1136	(ABC) transporter
MJ_RS04265	COG0577	efflux transmembrane transporter activity
MJ_RS04265	COG1136	(ABC) transporter
MJ_RS04310	COG0006	proline dipeptidase activity
MJ_RS04340	COG2078	PFAM AMMECR1 domain protein
MJ_RS04365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MJ_RS04375	COG0688	phosphatidylethanolamine metabolic process
MJ_RS04410	COG0544	peptidyl-prolyl cis-trans isomerase activity
MJ_RS04430	COG0519	Catalyzes the synthesis of GMP from XMP
MJ_RS04430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MJ_RS04580	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MJ_RS04620	COG1304	FMN binding
MJ_RS04625	COG2048	Heterodisulfide reductase, subunit B
MJ_RS04645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MJ_RS04660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MJ_RS04685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MJ_RS04710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MJ_RS04715	COG2813	Specifically methylates the guanine in position
MJ_RS04720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MJ_RS04730	COG2255	four-way junction helicase activity
MJ_RS04740	COG0303	'Molybdopterin
MJ_RS04750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MJ_RS04840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MJ_RS04870	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MJ_RS04870	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MJ_RS04875	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MJ_RS04905	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MJ_RS04920	COG0134	indole-3-glycerol-phosphate synthase activity
MJ_RS04930	COG1160	GTP binding
MJ_RS04940	COG0517	IMP dehydrogenase activity
MJ_RS04940	COG0516	GMP reductase activity
MJ_RS04950	COG2894	cell division
MJ_RS04970	COG2890	protein-(glutamine-N5) methyltransferase activity
MJ_RS04975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MJ_RS04985	COG0301	tRNA thio-modification
MJ_RS05000	COG1836	PFAM Integral membrane protein DUF92
MJ_RS05050	COG0151	Belongs to the GarS family
MJ_RS05055	COG0390	transport system, permease component
MJ_RS05075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MJ_RS05075	COG1199	ATP-dependent helicase activity
MJ_RS05100	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MJ_RS05105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MJ_RS05120	COG1458	PINc domain ribonuclease
MJ_RS05125	COG1323	Belongs to the UPF0348 family
MJ_RS05150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MJ_RS05170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MJ_RS05175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MJ_RS05205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MJ_RS05210	COG0693	protein deglycase activity
MJ_RS05215	COG2217	Heavy metal translocating P-type atpase
MJ_RS05230	COG0750	zinc metalloprotease
MJ_RS05235	COG2095	MarC family integral membrane protein
MJ_RS05240	COG0175	sulfate reduction
MJ_RS05285	COG0052	Belongs to the universal ribosomal protein uS2 family
MJ_RS05325	COG0425	Belongs to the sulfur carrier protein TusA family
MJ_RS05340	COG0409	Hydrogenase expression formation protein
MJ_RS05345	COG1587	Uroporphyrinogen-III synthase
MJ_RS05355	COG0312	modulator of DNA gyrase
MJ_RS05370	COG0459	protein refolding
MJ_RS05375	COG0124	histidyl-tRNA synthetase
MJ_RS05390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MJ_RS05415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MJ_RS05420	COG0704	Plays a role in the regulation of phosphate uptake
MJ_RS05440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MJ_RS05445	COG0581	inorganic phosphate transmembrane transporter activity
MJ_RS05450	COG0573	inorganic phosphate transmembrane transporter activity
MJ_RS05470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MJ_RS05475	COG0505	Belongs to the CarA family
MJ_RS05495	COG4152	abc transporter atp-binding protein
MJ_RS05505	COG3681	Belongs to the UPF0597 family
MJ_RS05510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MJ_RS05515	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MJ_RS05515	COG3261	NADH dehydrogenase
MJ_RS05545	COG0598	Magnesium transport protein CorA
MJ_RS05565	COG0133	tryptophan synthase activity
MJ_RS05570	COG0159	tryptophan synthase activity
MJ_RS05580	COG0085	RNA polymerase activity
MJ_RS05585	COG0085	RNA polymerase activity
MJ_RS05590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MJ_RS05595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MJ_RS05615	COG0049	tRNA binding
MJ_RS05630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MJ_RS05635	COG2192	nodulation
MJ_RS05650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MJ_RS05650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MJ_RS05670	COG1216	Glycosyl transferase, family 2
MJ_RS05675	COG2192	nodulation
MJ_RS05680	COG0438	transferase activity, transferring glycosyl groups
MJ_RS05695	COG3980	spore coat polysaccharide biosynthesis protein
MJ_RS05710	COG2089	acid synthase
MJ_RS05715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MJ_RS05765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MJ_RS05790	COG0432	Pfam Uncharacterised protein family UPF0047
MJ_RS05805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MJ_RS05820	COG0083	homoserine kinase activity
MJ_RS05840	COG0310	cobalt ion transport
MJ_RS05850	COG1433	Dinitrogenase iron-molybdenum cofactor
MJ_RS05850	COG0535	radical SAM domain protein
MJ_RS05870	COG0019	diaminopimelate decarboxylase activity
MJ_RS05885	COG1891	lyase activity
MJ_RS05890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MJ_RS05895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MJ_RS05910	COG0083	homoserine kinase activity
MJ_RS05915	COG0569	domain protein
MJ_RS05935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MJ_RS05950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MJ_RS05965	COG0434	BtpA family
MJ_RS05970	COG0367	asparagine synthase
MJ_RS05975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MJ_RS06015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MJ_RS06030	COG2151	metal-sulfur cluster biosynthetic enzyme
MJ_RS06035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MJ_RS06040	COG0519	Catalyzes the synthesis of GMP from XMP
MJ_RS06040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MJ_RS06060	COG0315	cyclic pyranopterin monophosphate synthase activity
MJ_RS06085	COG2045	Belongs to the ComB family
MJ_RS06095	COG0003	Pfam Anion-transporting ATPase
MJ_RS06100	COG0668	transmembrane transport
MJ_RS06120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MJ_RS06160	COG1078	dGTPase activity
MJ_RS06180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MJ_RS06190	COG0037	tRNA processing
MJ_RS06220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MJ_RS06245	COG0243	molybdopterin cofactor binding
MJ_RS06250	COG1229	Formylmethanofuran dehydrogenase subunit A
MJ_RS06255	COG0393	Putative heavy-metal-binding
MJ_RS06275	COG0504	CTP synthase activity
MJ_RS06285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MJ_RS06290	COG0438	transferase activity, transferring glycosyl groups
MJ_RS06295	COG0628	permease
MJ_RS06300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MJ_RS06300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MJ_RS06330	COG0725	ABC transporter, periplasmic molybdate-binding protein
MJ_RS06340	COG1397	ADP-ribosylglycohydrolase
MJ_RS06360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MJ_RS06365	COG3259	Nickel-dependent hydrogenase
MJ_RS06375	COG2768	binding domain, Protein
MJ_RS06385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MJ_RS06400	COG1185	polyribonucleotide nucleotidyltransferase activity
MJ_RS06430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MJ_RS06460	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MJ_RS06485	COG1183	phosphatidylcholine synthase activity
MJ_RS06490	COG1451	nucleotide metabolic process
MJ_RS06505	COG2361	Protein of unknown function DUF86
MJ_RS06560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MJ_RS06565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MJ_RS06575	COG0439	Biotin carboxylase
MJ_RS06580	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MJ_RS06585	COG0511	ligase activity, forming carbon-carbon bonds
MJ_RS06585	COG5016	pyruvate
MJ_RS06590	COG0516	GMP reductase activity
MJ_RS06590	COG0517	IMP dehydrogenase activity
MJ_RS06610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MJ_RS06615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MJ_RS06620	COG0442	prolyl-tRNA aminoacylation
MJ_RS06640	COG0517	IMP dehydrogenase activity
MJ_RS06640	COG1125	glycine betaine transport
MJ_RS06645	COG1342	Belongs to the UPF0251 family
MJ_RS06660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MJ_RS06680	COG1465	3-dehydroquinate synthase
MJ_RS06690	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MJ_RS06695	COG2226	methyltransferase
MJ_RS06705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MJ_RS06715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MJ_RS06720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MJ_RS06725	COG0301	tRNA thio-modification
MJ_RS06725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MJ_RS06735	COG0528	UMP kinase activity
MJ_RS06760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MJ_RS06760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MJ_RS06770	COG0105	UTP biosynthetic process
MJ_RS06800	COG0066	3-isopropylmalate dehydratase activity
MJ_RS06820	COG0569	domain protein
MJ_RS06820	COG0475	glutathione-regulated potassium exporter activity
MJ_RS06825	COG0129	dihydroxy-acid dehydratase activity
MJ_RS06830	COG0066	3-isopropylmalate dehydratase activity
MJ_RS06925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MJ_RS06925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MJ_RS06935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MJ_RS06940	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MJ_RS06950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MJ_RS06955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MJ_RS07000	COG0651	ATP synthesis coupled electron transport
MJ_RS07015	COG0731	radical SAM domain protein
MJ_RS07015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MJ_RS07030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MJ_RS07040	COG2814	Major facilitator Superfamily
MJ_RS07045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MJ_RS07050	COG0733	neurotransmitter:sodium symporter activity
MJ_RS07065	COG0419	ATPase involved in DNA repair
MJ_RS07080	COG0640	Transcriptional regulator
MJ_RS07085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MJ_RS07105	COG0024	Methionine aminopeptidase
MJ_RS07120	COG0012	GTP binding
MJ_RS07135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MJ_RS07160	COG1160	GTP binding
MJ_RS07170	COG1104	cysteine desulfurase activity
MJ_RS07180	COG0004	ammonium transporteR
MJ_RS07185	COG0347	Belongs to the P(II) protein family
MJ_RS07195	COG0174	glutamine synthetase
MJ_RS07200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MJ_RS07225	COG0067	glutamate synthase
MJ_RS07230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MJ_RS07260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MJ_RS07270	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MJ_RS07285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MJ_RS07290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MJ_RS07300	COG0585	pseudouridine synthase activity
MJ_RS07310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MJ_RS07340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MJ_RS07360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MJ_RS07365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MJ_RS07370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MJ_RS07390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MJ_RS07415	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MJ_RS07420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MJ_RS07435	COG0436	Aminotransferase
MJ_RS07440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MJ_RS07480	COG0563	adenylate kinase activity
MJ_RS07490	COG1204	response to ionizing radiation
MJ_RS07505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MJ_RS07505	COG0517	IMP dehydrogenase activity
MJ_RS07515	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MJ_RS07530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MJ_RS07545	COG1012	belongs to the aldehyde dehydrogenase family
MJ_RS07555	COG0393	Putative heavy-metal-binding
MJ_RS07575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MJ_RS07605	COG1797	cobyrinic acid a,c-diamide synthase activity
MJ_RS07615	COG2255	four-way junction helicase activity
MJ_RS07630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MJ_RS07645	COG3063	Type IV pilus biogenesis stability protein PilW
MJ_RS07655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MJ_RS07660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MJ_RS07695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MJ_RS07700	COG1525	nuclease
MJ_RS07735	COG0543	2 iron, 2 sulfur cluster binding
MJ_RS07765	COG2264	protein methyltransferase activity
MJ_RS07785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MJ_RS07800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MJ_RS07820	COG1851	Uncharacterised protein family (UPF0128)
MJ_RS07825	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MJ_RS07830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MJ_RS07875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MJ_RS07895	COG2342	PFAM TM1410 hypothetical-related protein
MJ_RS07900	COG0037	tRNA processing
MJ_RS07905	COG0436	Aminotransferase
MJ_RS07940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MJ_RS07945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MJ_RS07950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MJ_RS07965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MJ_RS08025	COG1234	tRNA 3'-trailer cleavage
MJ_RS08040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MJ_RS08050	COG0577	efflux transmembrane transporter activity
MJ_RS08050	COG1136	(ABC) transporter
MJ_RS08055	COG1136	(ABC) transporter
MJ_RS08075	COG1110	DNA topoisomerase II activity
MJ_RS08075	COG1110	DNA topoisomerase II activity
MJ_RS08090	COG0121	glutamine amidotransferase
MJ_RS08120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MJ_RS08125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MJ_RS08130	COG0025	NhaP-type Na H and K H
MJ_RS08140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MJ_RS08170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MJ_RS08190	COG4956	integral membrane protein (PIN domain superfamily)
MJ_RS08230	COG0402	S-adenosylhomocysteine deaminase activity
MJ_RS08240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MJ_RS08245	COG1373	ATPase (AAA superfamily
MJ_RS08270	COG0183	Belongs to the thiolase family
MJ_RS08300	COG0017	Asparaginyl-tRNA synthetase
MJ_RS08310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MJ_RS08325	COG2814	Major facilitator Superfamily
MJ_RS08365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MJ_RS08370	COG0310	cobalt ion transport
MJ_RS08385	COG1122	ATPase activity
MJ_RS08405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MJ_RS08405	COG0519	Catalyzes the synthesis of GMP from XMP
MJ_RS08410	COG1704	LemA family
MJ_RS08435	COG0540	Belongs to the ATCase OTCase family
MJ_RS08445	COG1720	tRNA m6t6A37 methyltransferase activity
MJ_RS08460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MJ_RS08460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MJ_RS08485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MJ_RS08495	COG0560	Phosphoserine phosphatase
MJ_RS08505	COG0473	3-isopropylmalate dehydrogenase activity
MJ_RS08510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MJ_RS08515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MJ_RS08535	COG0460	homoserine dehydrogenase
MJ_RS08540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MJ_RS08555	COG0297	glycogen (starch) synthase activity
MJ_RS08585	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MJ_RS08605	COG0516	GMP reductase activity
MJ_RS08605	COG0517	IMP dehydrogenase activity
MJ_RS08625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MJ_RS08710	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MJ_RS08720	COG0482	sulfurtransferase activity
MJ_RS08745	COG1196	nuclear chromosome segregation
MJ_RS08755	COG0602	queuosine metabolic process
MJ_RS08760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MJ_RS08770	COG0047	phosphoribosylformylglycinamidine synthase activity
MJ_RS08785	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
MJ_RS08790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MJ_RS08790	COG0551	DNA topoisomerase type I activity
MJ_RS08795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MJ_RS08835	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MJ_RS08840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MJ_RS08845	COG0746	molybdenum cofactor guanylyltransferase activity
MJ_RS08855	COG2848	UPF0210 protein
MJ_RS08875	COG1337	RAMP superfamily
MJ_RS08900	COG0101	tRNA pseudouridine synthase activity
MJ_RS08910	COG2095	MarC family integral membrane protein
MJ_RS08935	COG0501	Belongs to the peptidase M48B family
MJ_RS09090	COG1192	Involved in chromosome partitioning
MJ_RS09175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MJ_RS09190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MJ_RS09305	COG2361	Protein of unknown function DUF86
MJ_RS09375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity