locus-tag	class	description
MCMEM_RS00030	COG0018	arginyl-trna synthetase
MCMEM_RS00035	COG3326	Membrane
MCMEM_RS00045	COG0523	cobalamin synthesis protein
MCMEM_RS00065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCMEM_RS00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCMEM_RS00085	COG0517	IMP dehydrogenase activity
MCMEM_RS00085	COG0617	tRNA 3'-terminal CCA addition
MCMEM_RS00085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCMEM_RS00090	COG0617	tRNA 3'-terminal CCA addition
MCMEM_RS00090	COG0517	IMP dehydrogenase activity
MCMEM_RS00090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCMEM_RS00095	COG0517	IMP dehydrogenase activity
MCMEM_RS00100	COG0517	IMP dehydrogenase activity
MCMEM_RS00100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCMEM_RS00100	COG0617	tRNA 3'-terminal CCA addition
MCMEM_RS00115	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MCMEM_RS00120	COG0430	RNA-3'-phosphate cyclase activity
MCMEM_RS00150	COG0277	FAD linked oxidase domain protein
MCMEM_RS00175	COG0084	hydrolase, TatD family'
MCMEM_RS00180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCMEM_RS00220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCMEM_RS00225	COG0733	neurotransmitter:sodium symporter activity
MCMEM_RS00235	COG0316	Belongs to the HesB IscA family
MCMEM_RS00245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCMEM_RS00250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MCMEM_RS00260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MCMEM_RS00295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MCMEM_RS00310	COG0330	HflC and HflK could
MCMEM_RS00315	COG1185	polyribonucleotide nucleotidyltransferase activity
MCMEM_RS00320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MCMEM_RS00330	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCMEM_RS00335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MCMEM_RS00350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MCMEM_RS00355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCMEM_RS00360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MCMEM_RS00365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MCMEM_RS00480	COG1121	(ABC) transporter
MCMEM_RS00495	COG0107	imidazoleglycerol-phosphate synthase activity
MCMEM_RS00505	COG0826	peptidase U32
MCMEM_RS00520	COG2226	methyltransferase
MCMEM_RS00545	COG1945	arginine decarboxylase activity
MCMEM_RS00555	COG1918	ferrous iron import across plasma membrane
MCMEM_RS00555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MCMEM_RS00565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCMEM_RS00575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MCMEM_RS00590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MCMEM_RS00590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MCMEM_RS00605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MCMEM_RS00615	COG0140	phosphoribosyl-ATP diphosphatase activity
MCMEM_RS00615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MCMEM_RS00625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCMEM_RS00630	COG0436	Aminotransferase
MCMEM_RS00635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MCMEM_RS00650	COG1160	GTP binding
MCMEM_RS00660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCMEM_RS00670	COG0010	Belongs to the arginase family
MCMEM_RS00675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MCMEM_RS00680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCMEM_RS00680	COG5549	protein import
MCMEM_RS00690	COG1525	nuclease
MCMEM_RS00695	COG2217	Heavy metal translocating P-type atpase
MCMEM_RS00700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCMEM_RS00755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCMEM_RS00760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MCMEM_RS00765	COG0347	Belongs to the P(II) protein family
MCMEM_RS00770	COG0004	ammonium transporteR
MCMEM_RS00780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MCMEM_RS00785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCMEM_RS00790	COG0534	Mate efflux family protein
MCMEM_RS00810	COG0138	bifunctional purine biosynthesis protein purh
MCMEM_RS00815	COG0175	sulfate reduction
MCMEM_RS00835	COG0183	Belongs to the thiolase family
MCMEM_RS00855	COG0616	signal peptide processing
MCMEM_RS00860	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MCMEM_RS00865	COG1012	belongs to the aldehyde dehydrogenase family
MCMEM_RS00880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MCMEM_RS00900	COG0081	regulation of translation
MCMEM_RS00905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MCMEM_RS00925	COG0535	radical SAM domain protein
MCMEM_RS00930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCMEM_RS00940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MCMEM_RS00940	COG0321	lipoyl(octanoyl) transferase activity
MCMEM_RS00945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS00960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCMEM_RS00965	COG0012	GTP binding
MCMEM_RS00980	COG0459	protein refolding
MCMEM_RS00990	COG1268	BioY protein
MCMEM_RS00995	COG1122	ATPase activity
MCMEM_RS01000	COG1122	ATPase activity
MCMEM_RS01005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MCMEM_RS01010	COG0640	Transcriptional regulator
MCMEM_RS01055	COG0577	efflux transmembrane transporter activity
MCMEM_RS01055	COG1136	(ABC) transporter
MCMEM_RS01060	COG1136	(ABC) transporter
MCMEM_RS01080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MCMEM_RS01105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MCMEM_RS01120	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MCMEM_RS01125	COG0071	Belongs to the small heat shock protein (HSP20) family
MCMEM_RS01130	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MCMEM_RS01130	COG0778	Nitroreductase
MCMEM_RS01140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCMEM_RS01145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCMEM_RS01175	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MCMEM_RS01190	COG0287	Prephenate dehydrogenase
MCMEM_RS01190	COG1605	Chorismate mutase
MCMEM_RS01195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MCMEM_RS01200	COG0710	3-dehydroquinate dehydratase activity
MCMEM_RS01205	COG1465	3-dehydroquinate synthase
MCMEM_RS01210	COG1830	Aldolase
MCMEM_RS01215	COG0519	Catalyzes the synthesis of GMP from XMP
MCMEM_RS01215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCMEM_RS01245	COG0110	maltose O-acetyltransferase activity
MCMEM_RS01280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCMEM_RS01285	COG1086	Polysaccharide biosynthesis protein
MCMEM_RS01340	COG0561	phosphatase activity
MCMEM_RS01350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS01360	COG0864	Transcriptional regulator
MCMEM_RS01365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MCMEM_RS01375	COG1392	Phosphate transport regulator
MCMEM_RS01380	COG0306	phosphate transporter
MCMEM_RS01410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCMEM_RS01415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MCMEM_RS01435	COG2816	NAD+ diphosphatase activity
MCMEM_RS01445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCMEM_RS01445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCMEM_RS01455	COG1234	tRNA 3'-trailer cleavage
MCMEM_RS01465	COG2894	cell division
MCMEM_RS01470	COG0489	protein tyrosine kinase activity
MCMEM_RS01500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCMEM_RS01505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCMEM_RS01515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCMEM_RS01520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MCMEM_RS01535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCMEM_RS01545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCMEM_RS01560	COG0436	Aminotransferase
MCMEM_RS01565	COG1522	sequence-specific DNA binding
MCMEM_RS01575	COG1234	tRNA 3'-trailer cleavage
MCMEM_RS01590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS01600	COG5002	protein histidine kinase activity
MCMEM_RS01605	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MCMEM_RS01620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MCMEM_RS01630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS01640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCMEM_RS01655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MCMEM_RS01660	COG1078	dGTPase activity
MCMEM_RS01665	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MCMEM_RS01715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCMEM_RS01720	COG1116	anion transmembrane transporter activity
MCMEM_RS01740	COG0489	protein tyrosine kinase activity
MCMEM_RS01745	COG1342	Belongs to the UPF0251 family
MCMEM_RS01760	COG0708	Exodeoxyribonuclease III
MCMEM_RS01765	COG0459	protein refolding
MCMEM_RS01815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCMEM_RS01830	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCMEM_RS01835	COG1013	pyruvate-flavodoxin oxidoreductase activity
MCMEM_RS01840	COG1115	amino acid carrier protein
MCMEM_RS01845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCMEM_RS01855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCMEM_RS01860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCMEM_RS01875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MCMEM_RS01885	COG0351	phosphomethylpyrimidine kinase
MCMEM_RS01885	COG0352	thiamine-phosphate diphosphorylase activity
MCMEM_RS01900	COG0745	RESPONSE REGULATOR receiver
MCMEM_RS01905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCMEM_RS01915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MCMEM_RS01920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCMEM_RS01925	COG1797	cobyrinic acid a,c-diamide synthase activity
MCMEM_RS01955	COG0688	phosphatidylethanolamine metabolic process
MCMEM_RS01960	COG1183	phosphatidylcholine synthase activity
MCMEM_RS01965	COG0542	response to heat
MCMEM_RS01985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCMEM_RS01990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCMEM_RS02015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MCMEM_RS02060	COG2814	Major facilitator Superfamily
MCMEM_RS02065	COG1119	ATPase activity
MCMEM_RS02095	COG0129	dihydroxy-acid dehydratase activity
MCMEM_RS02125	COG1047	Peptidyl-prolyl cis-trans
MCMEM_RS02180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MCMEM_RS02190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MCMEM_RS02195	COG1691	(AIR) carboxylase
MCMEM_RS02205	COG0826	peptidase U32
MCMEM_RS02210	COG0424	maF-like protein
MCMEM_RS02220	COG0028	Belongs to the TPP enzyme family
MCMEM_RS02230	COG0668	transmembrane transport
MCMEM_RS02265	COG0539	negative regulation of cytoplasmic translation
MCMEM_RS02290	COG0745	RESPONSE REGULATOR receiver
MCMEM_RS02305	COG5012	cobalamin binding
MCMEM_RS02330	COG0745	RESPONSE REGULATOR receiver
MCMEM_RS02345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS02365	COG0556	nucleotide-excision repair
MCMEM_RS02385	COG0415	Belongs to the DNA photolyase family
MCMEM_RS02395	COG0534	Mate efflux family protein
MCMEM_RS02420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MCMEM_RS02425	COG3586	endonuclease activity
MCMEM_RS02430	COG0732	type I restriction modification DNA specificity domain
MCMEM_RS02435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MCMEM_RS02465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS02510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCMEM_RS02530	COG0668	transmembrane transport
MCMEM_RS02540	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCMEM_RS02550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCMEM_RS02565	COG1573	uracil-dna glycosylase
MCMEM_RS02585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCMEM_RS02590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCMEM_RS02595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCMEM_RS02660	COG0402	S-adenosylhomocysteine deaminase activity
MCMEM_RS02665	COG0589	response to stress
MCMEM_RS02670	COG0617	tRNA 3'-terminal CCA addition
MCMEM_RS02670	COG0517	IMP dehydrogenase activity
MCMEM_RS02670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCMEM_RS02675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCMEM_RS02685	COG0785	Cytochrome C biogenesis protein
MCMEM_RS02720	COG2264	protein methyltransferase activity
MCMEM_RS02725	COG1492	cobalamin metabolic process
MCMEM_RS02730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MCMEM_RS02735	COG0135	phosphoribosylanthranilate isomerase activity
MCMEM_RS02740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MCMEM_RS02745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MCMEM_RS02745	COG0512	Glutamine amidotransferase of anthranilate synthase
MCMEM_RS02765	COG1051	belongs to the nudix hydrolase family
MCMEM_RS02765	COG1056	cytidyltransferase-related domain
MCMEM_RS02770	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MCMEM_RS02800	COG0431	NADPH-dependent FMN reductase
MCMEM_RS02810	COG1592	Rubrerythrin
MCMEM_RS02825	COG1260	myo-inositol-1-phosphate synthase
MCMEM_RS02835	COG0426	domain, Protein
MCMEM_RS02845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCMEM_RS02860	COG0200	Binds to the 23S rRNA
MCMEM_RS02865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MCMEM_RS02870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCMEM_RS02890	COG0052	Belongs to the universal ribosomal protein uS2 family
MCMEM_RS02895	COG1355	regulation of microtubule-based process
MCMEM_RS02910	COG1304	FMN binding
MCMEM_RS02920	COG0142	geranyltranstransferase activity
MCMEM_RS02945	COG0640	Transcriptional regulator
MCMEM_RS02970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MCMEM_RS02975	COG0613	PHP domain protein
MCMEM_RS02990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MCMEM_RS02995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MCMEM_RS03080	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MCMEM_RS03090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCMEM_RS03100	COG0247	lactate metabolic process
MCMEM_RS03100	COG2181	nitrate reductase activity
MCMEM_RS03120	COG0745	RESPONSE REGULATOR receiver
MCMEM_RS03130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MCMEM_RS03135	COG0088	Forms part of the polypeptide exit tunnel
MCMEM_RS03145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCMEM_RS03150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MCMEM_RS03160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCMEM_RS03165	COG0255	Belongs to the universal ribosomal protein uL29 family
MCMEM_RS03180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MCMEM_RS03195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCMEM_RS03230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MCMEM_RS03250	COG0563	adenylate kinase activity
MCMEM_RS03305	COG0697	spore germination
MCMEM_RS03310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MCMEM_RS03315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MCMEM_RS03320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MCMEM_RS03355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCMEM_RS03365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCMEM_RS03380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MCMEM_RS03400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MCMEM_RS03415	COG1469	GTP cyclohydrolase I activity
MCMEM_RS03425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCMEM_RS03435	COG0519	Catalyzes the synthesis of GMP from XMP
MCMEM_RS03435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCMEM_RS03440	COG0514	ATP-dependent DNA helicase (RecQ)
MCMEM_RS03450	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MCMEM_RS03460	COG0540	Belongs to the ATCase OTCase family
MCMEM_RS03465	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MCMEM_RS03470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MCMEM_RS03475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCMEM_RS03490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCMEM_RS03515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCMEM_RS03525	COG0009	L-threonylcarbamoyladenylate synthase
MCMEM_RS03530	COG1320	monovalent cation:proton antiporter activity
MCMEM_RS03540	COG1863	multisubunit Na H antiporter MnhE subunit
MCMEM_RS03545	COG0651	ATP synthesis coupled electron transport
MCMEM_RS03550	COG1006	Multisubunit Na H antiporter MnhC subunit
MCMEM_RS03555	COG2111	Na H antiporter
MCMEM_RS03560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MCMEM_RS03560	COG2111	Na H antiporter
MCMEM_RS03565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MCMEM_RS03615	COG1410	methionine synthase
MCMEM_RS03615	COG0646	methionine synthase
MCMEM_RS03645	COG0306	phosphate transporter
MCMEM_RS03660	COG0175	sulfate reduction
MCMEM_RS03665	COG2895	sulfate adenylyltransferase (ATP) activity
MCMEM_RS03665	COG0529	Catalyzes the synthesis of activated sulfate
MCMEM_RS03675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MCMEM_RS03680	COG0133	tryptophan synthase activity
MCMEM_RS03685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MCMEM_RS03700	COG3063	Type IV pilus biogenesis stability protein PilW
MCMEM_RS03715	COG0673	inositol 2-dehydrogenase activity
MCMEM_RS03730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MCMEM_RS03770	COG0552	protein localization to endoplasmic reticulum
MCMEM_RS03775	COG0159	tryptophan synthase activity
MCMEM_RS03780	COG0133	tryptophan synthase activity
MCMEM_RS03785	COG0134	indole-3-glycerol-phosphate synthase activity
MCMEM_RS03820	COG0492	ferredoxin-NADP+ reductase activity
MCMEM_RS03865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MCMEM_RS03895	COG2210	Belongs to the sulfur carrier protein TusA family
MCMEM_RS03900	COG0425	Belongs to the sulfur carrier protein TusA family
MCMEM_RS03920	COG1489	DNA binding
MCMEM_RS03925	COG2226	methyltransferase
MCMEM_RS03930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCMEM_RS03935	COG2814	Major facilitator Superfamily
MCMEM_RS03945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MCMEM_RS03950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS04005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MCMEM_RS04020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MCMEM_RS04025	COG1509	lysine 2,3-aminomutase activity
MCMEM_RS04045	COG0442	prolyl-tRNA aminoacylation
MCMEM_RS04050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MCMEM_RS04090	COG1185	polyribonucleotide nucleotidyltransferase activity
MCMEM_RS04095	COG1185	polyribonucleotide nucleotidyltransferase activity
MCMEM_RS04130	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MCMEM_RS04150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCMEM_RS04170	COG0590	tRNA wobble adenosine to inosine editing
MCMEM_RS04205	COG0105	UTP biosynthetic process
MCMEM_RS04210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCMEM_RS04225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS04250	COG0534	Mate efflux family protein
MCMEM_RS04260	COG3118	belongs to the thioredoxin family
MCMEM_RS04265	COG0318	PFAM AMP-dependent synthetase and ligase
MCMEM_RS04285	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MCMEM_RS04305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCMEM_RS04315	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MCMEM_RS04345	COG1136	(ABC) transporter
MCMEM_RS04345	COG0577	efflux transmembrane transporter activity
MCMEM_RS04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCMEM_RS04355	COG0513	Belongs to the DEAD box helicase family
MCMEM_RS04370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCMEM_RS04410	COG1047	Peptidyl-prolyl cis-trans
MCMEM_RS04415	COG5002	protein histidine kinase activity
MCMEM_RS04420	COG2239	Acts as a magnesium transporter
MCMEM_RS04440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MCMEM_RS04455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCMEM_RS04460	COG0644	oxidoreductase
MCMEM_RS04465	COG2105	PFAM AIG2 family protein
MCMEM_RS04475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MCMEM_RS04495	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MCMEM_RS04500	COG1104	cysteine desulfurase activity
MCMEM_RS04505	COG0822	iron-sulfur transferase activity
MCMEM_RS04690	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MCMEM_RS04715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCMEM_RS04720	COG0569	domain protein
MCMEM_RS04725	COG0730	response to heat
MCMEM_RS04765	COG0047	phosphoribosylformylglycinamidine synthase activity
MCMEM_RS04805	COG0469	pyruvate kinase activity
MCMEM_RS04810	COG1139	Iron-sulfur cluster binding protein
MCMEM_RS04820	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MCMEM_RS04830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCMEM_RS04845	COG0693	protein deglycase activity
MCMEM_RS04855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MCMEM_RS04855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MCMEM_RS04860	COG0436	Aminotransferase
MCMEM_RS04870	COG0530	calcium, potassium:sodium antiporter activity
MCMEM_RS04885	COG0297	glycogen (starch) synthase activity
MCMEM_RS04915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MCMEM_RS04925	COG5002	protein histidine kinase activity
MCMEM_RS04935	COG0725	ABC transporter, periplasmic molybdate-binding protein
MCMEM_RS04940	COG4149	molybdate abc transporter
MCMEM_RS04945	COG3842	ATPase activity
MCMEM_RS04965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MCMEM_RS04970	COG0574	Belongs to the PEP-utilizing enzyme family
MCMEM_RS04970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCMEM_RS04995	COG0714	Associated with various cellular activities
MCMEM_RS05005	COG1605	Chorismate mutase
MCMEM_RS05005	COG0077	Prephenate dehydratase
MCMEM_RS05035	COG5012	cobalamin binding
MCMEM_RS05050	COG5012	cobalamin binding
MCMEM_RS05060	COG5012	cobalamin binding
MCMEM_RS05085	COG0523	cobalamin synthesis protein
MCMEM_RS05105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MCMEM_RS05110	COG2848	UPF0210 protein
MCMEM_RS05115	COG3830	Belongs to the UPF0237 family
MCMEM_RS05125	COG0530	calcium, potassium:sodium antiporter activity
MCMEM_RS05145	COG0784	Response regulator, receiver
MCMEM_RS05165	COG0531	amino acid
MCMEM_RS05180	COG5012	cobalamin binding
MCMEM_RS05215	COG0531	amino acid
MCMEM_RS05230	COG5012	cobalamin binding
MCMEM_RS05250	COG1748	Saccharopine dehydrogenase
MCMEM_RS05255	COG0483	inositol monophosphate 1-phosphatase activity
MCMEM_RS05260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MCMEM_RS05265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCMEM_RS05320	COG1045	serine acetyltransferase
MCMEM_RS05325	COG0644	oxidoreductase
MCMEM_RS05335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCMEM_RS05350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MCMEM_RS05355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MCMEM_RS05360	COG0546	phosphoglycolate phosphatase activity
MCMEM_RS05380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCMEM_RS05385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCMEM_RS05390	COG0314	molybdopterin synthase activity
MCMEM_RS05395	COG2003	Belongs to the UPF0758 family
MCMEM_RS05400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MCMEM_RS05405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MCMEM_RS05440	COG4175	Glycine betaine
MCMEM_RS05440	COG3448	diguanylate cyclase activity
MCMEM_RS05450	COG0154	amidase activity
MCMEM_RS05470	COG1515	deoxyribonuclease V activity
MCMEM_RS05495	COG0581	inorganic phosphate transmembrane transporter activity
MCMEM_RS05500	COG0573	inorganic phosphate transmembrane transporter activity
MCMEM_RS05505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MCMEM_RS05510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MCMEM_RS05515	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCMEM_RS05530	COG1733	regulation of RNA biosynthetic process
MCMEM_RS05535	COG0655	NAD(P)H dehydrogenase (quinone) activity
MCMEM_RS05585	COG2205	protein histidine kinase activity
MCMEM_RS05590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCMEM_RS05615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCMEM_RS05655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MCMEM_RS05660	COG0017	Asparaginyl-tRNA synthetase
MCMEM_RS05665	COG2249	NAD(P)H dehydrogenase (quinone) activity
MCMEM_RS05685	COG0187	DNA topoisomerase II activity
MCMEM_RS05690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCMEM_RS05695	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MCMEM_RS05700	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MCMEM_RS05705	COG2264	protein methyltransferase activity
MCMEM_RS05740	COG0004	ammonium transporteR
MCMEM_RS05745	COG2153	protein acetylation
MCMEM_RS05755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MCMEM_RS05755	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCMEM_RS05765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCMEM_RS05780	COG2217	Heavy metal translocating P-type atpase
MCMEM_RS05785	COG2608	mercury ion transmembrane transporter activity
MCMEM_RS05805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCMEM_RS05825	COG1205	dead DEAH box helicase
MCMEM_RS05825	COG1111	helicase
MCMEM_RS05835	COG0693	protein deglycase activity
MCMEM_RS05840	COG0531	amino acid
MCMEM_RS05850	COG1174	glycine betaine transport
MCMEM_RS05860	COG0517	IMP dehydrogenase activity
MCMEM_RS05860	COG1125	glycine betaine transport
MCMEM_RS05870	COG0719	Fe-S assembly protein
MCMEM_RS05875	COG0396	ATPase activity
MCMEM_RS05885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCMEM_RS05930	COG0765	amino acid transport
MCMEM_RS05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCMEM_RS05940	COG1331	Highly conserved protein containing a thioredoxin domain
MCMEM_RS05980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCMEM_RS05985	COG2076	Multidrug Resistance protein
MCMEM_RS05990	COG1136	(ABC) transporter
MCMEM_RS05990	COG0577	efflux transmembrane transporter activity
MCMEM_RS05995	COG0577	efflux transmembrane transporter activity
MCMEM_RS06005	COG1136	(ABC) transporter
MCMEM_RS06010	COG0598	Magnesium transport protein CorA
MCMEM_RS06015	COG2095	MarC family integral membrane protein
MCMEM_RS06025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCMEM_RS06030	COG1120	ATPase activity
MCMEM_RS06065	COG0789	Transcriptional regulator
MCMEM_RS06070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCMEM_RS06075	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MCMEM_RS06075	COG0778	Nitroreductase
MCMEM_RS06080	COG1741	Belongs to the pirin family
MCMEM_RS06085	COG0659	secondary active sulfate transmembrane transporter activity
MCMEM_RS06105	COG0450	alkyl hydroperoxide reductase
MCMEM_RS06130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MCMEM_RS06145	COG1160	GTP binding
MCMEM_RS06150	COG4895	conserved protein (DUF2196)
MCMEM_RS06180	COG2205	protein histidine kinase activity
MCMEM_RS06190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MCMEM_RS06200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MCMEM_RS06225	COG5002	protein histidine kinase activity
MCMEM_RS06280	COG1136	(ABC) transporter
MCMEM_RS06290	COG0577	efflux transmembrane transporter activity
MCMEM_RS06395	COG1606	tRNA processing
MCMEM_RS06400	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MCMEM_RS06405	COG1691	(AIR) carboxylase
MCMEM_RS06410	COG1309	transcriptional regulator
MCMEM_RS06415	COG0667	Aldo Keto reductase
MCMEM_RS06425	COG2814	Major facilitator Superfamily
MCMEM_RS06435	COG1794	racemase activity, acting on amino acids and derivatives
MCMEM_RS06455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MCMEM_RS06490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MCMEM_RS06510	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MCMEM_RS06555	COG2226	methyltransferase
MCMEM_RS06575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCMEM_RS06580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MCMEM_RS06590	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCMEM_RS06600	COG1380	Effector of murein hydrolase LrgA
MCMEM_RS06605	COG1346	cytolysis
MCMEM_RS06645	COG2226	methyltransferase
MCMEM_RS06655	COG1733	regulation of RNA biosynthetic process
MCMEM_RS06665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCMEM_RS06700	COG4067	protein conserved in archaea
MCMEM_RS06700	COG0189	ligase activity
MCMEM_RS06705	COG0189	ligase activity
MCMEM_RS06740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCMEM_RS06745	COG2890	protein-(glutamine-N5) methyltransferase activity
MCMEM_RS06770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MCMEM_RS06775	COG1067	ATP-dependent peptidase activity
MCMEM_RS06775	COG0470	DNA polymerase III
MCMEM_RS06790	COG5002	protein histidine kinase activity
MCMEM_RS06790	COG5001	Diguanylate cyclase
MCMEM_RS06790	COG3447	MASE1 domain protein
MCMEM_RS06825	COG1013	pyruvate-flavodoxin oxidoreductase activity
MCMEM_RS06830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MCMEM_RS06830	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCMEM_RS06840	COG1049	propionate catabolic process, 2-methylcitrate cycle
MCMEM_RS06845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MCMEM_RS06850	COG0697	spore germination
MCMEM_RS06855	COG0577	efflux transmembrane transporter activity
MCMEM_RS06865	COG1136	(ABC) transporter
MCMEM_RS06880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCMEM_RS06940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCMEM_RS06975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MCMEM_RS07000	COG3118	belongs to the thioredoxin family
MCMEM_RS07010	COG2878	Part of a membrane complex involved in electron transport
MCMEM_RS07030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MCMEM_RS07055	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MCMEM_RS07060	COG1733	regulation of RNA biosynthetic process
MCMEM_RS07065	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MCMEM_RS07070	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MCMEM_RS07125	COG2226	methyltransferase
MCMEM_RS07135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCMEM_RS07185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MCMEM_RS07195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MCMEM_RS07200	COG0571	ribonuclease III activity
MCMEM_RS07265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCMEM_RS07275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCMEM_RS07285	COG0505	Belongs to the CarA family
MCMEM_RS07290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCMEM_RS07295	COG0137	argininosuccinate synthase activity
MCMEM_RS07300	COG0028	Belongs to the TPP enzyme family
MCMEM_RS07310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MCMEM_RS07325	COG1215	transferase activity, transferring glycosyl groups
MCMEM_RS07330	COG3769	mannosylglycerate metabolic process
MCMEM_RS07345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MCMEM_RS07350	COG1201	RNA secondary structure unwinding
MCMEM_RS07385	COG0318	PFAM AMP-dependent synthetase and ligase
MCMEM_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
MCMEM_RS07405	COG0039	L-malate dehydrogenase activity
MCMEM_RS07410	COG1363	Peptidase, m42
MCMEM_RS07415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCMEM_RS07420	COG0028	Belongs to the TPP enzyme family
MCMEM_RS07425	COG0440	acetolactate synthase activity
MCMEM_RS07430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MCMEM_RS07450	COG0589	response to stress
MCMEM_RS07460	COG1136	(ABC) transporter
MCMEM_RS07470	COG0577	efflux transmembrane transporter activity
MCMEM_RS07495	COG5002	protein histidine kinase activity
MCMEM_RS07540	COG1830	Aldolase
MCMEM_RS07545	COG1120	ATPase activity
MCMEM_RS07550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCMEM_RS07580	COG0423	glycine-tRNA ligase activity
MCMEM_RS07585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MCMEM_RS07635	COG0560	Phosphoserine phosphatase
MCMEM_RS07650	COG0535	radical SAM domain protein
MCMEM_RS07655	COG0644	oxidoreductase
MCMEM_RS07665	COG0343	queuine tRNA-ribosyltransferase activity
MCMEM_RS07685	COG0798	PFAM Bile acid sodium symporter
MCMEM_RS07735	COG1185	polyribonucleotide nucleotidyltransferase activity
MCMEM_RS07755	COG0277	FAD linked oxidase domain protein
MCMEM_RS07760	COG3875	lactate racemase activity
MCMEM_RS07790	COG2205	protein histidine kinase activity
MCMEM_RS07805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCMEM_RS07825	COG0574	Belongs to the PEP-utilizing enzyme family
MCMEM_RS07825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCMEM_RS07835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCMEM_RS07860	COG0459	protein refolding
MCMEM_RS07880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCMEM_RS07890	COG4555	ABC transporter
MCMEM_RS07895	COG0037	tRNA processing
MCMEM_RS07910	COG2226	methyltransferase
MCMEM_RS07915	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MCMEM_RS07925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCMEM_RS07930	COG0284	orotidine-5'-phosphate decarboxylase activity
MCMEM_RS07940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCMEM_RS07980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MCMEM_RS07985	COG0436	Aminotransferase
MCMEM_RS07990	COG3527	Alpha-acetolactate decarboxylase
MCMEM_RS08000	COG1121	(ABC) transporter
MCMEM_RS08005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCMEM_RS08015	COG5002	protein histidine kinase activity
MCMEM_RS08020	COG0165	Argininosuccinate lyase
MCMEM_RS08025	COG0252	asparaginase activity
MCMEM_RS08080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MCMEM_RS08090	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MCMEM_RS08095	COG1797	cobyrinic acid a,c-diamide synthase activity
MCMEM_RS08105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCMEM_RS08110	COG1138	Cytochrome C-type biogenesis protein
MCMEM_RS08130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MCMEM_RS08135	COG1151	hydroxylamine reductase activity
MCMEM_RS08145	COG0151	Belongs to the GarS family
MCMEM_RS08150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MCMEM_RS08205	COG0655	NAD(P)H dehydrogenase (quinone) activity
MCMEM_RS08215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MCMEM_RS08230	COG1342	Belongs to the UPF0251 family
MCMEM_RS08235	COG0731	radical SAM domain protein
MCMEM_RS08235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCMEM_RS08245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MCMEM_RS08280	COG0390	transport system, permease component
MCMEM_RS08285	COG1132	(ABC) transporter
MCMEM_RS08310	COG2181	nitrate reductase activity
MCMEM_RS08310	COG0247	lactate metabolic process
MCMEM_RS08375	COG1528	Iron-storage protein
MCMEM_RS08385	COG0535	radical SAM domain protein
MCMEM_RS08395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCMEM_RS08395	COG1648	precorrin-2 dehydrogenase activity
MCMEM_RS08405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MCMEM_RS08415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCMEM_RS08420	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MCMEM_RS08435	COG1793	dna ligase
MCMEM_RS08440	COG0460	homoserine dehydrogenase
MCMEM_RS08465	COG0501	Belongs to the peptidase M48B family
MCMEM_RS08475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MCMEM_RS08480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MCMEM_RS08485	COG0644	oxidoreductase
MCMEM_RS08495	COG1122	ATPase activity
MCMEM_RS08500	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MCMEM_RS08510	COG0310	cobalt ion transport
MCMEM_RS08520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCMEM_RS08525	COG1301	dicarboxylic acid transport
MCMEM_RS08570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCMEM_RS08580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MCMEM_RS08595	COG4221	oxidoreductase activity
MCMEM_RS08610	COG5012	cobalamin binding
MCMEM_RS08620	COG2205	protein histidine kinase activity
MCMEM_RS08650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MCMEM_RS08660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MCMEM_RS08690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCMEM_RS08695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCMEM_RS08700	COG0049	tRNA binding
MCMEM_RS08710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCMEM_RS08720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCMEM_RS08725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCMEM_RS08730	COG0085	RNA polymerase activity
MCMEM_RS08735	COG0085	RNA polymerase activity
MCMEM_RS08750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MCMEM_RS08755	COG0402	S-adenosylhomocysteine deaminase activity
MCMEM_RS08760	COG1418	mRNA catabolic process
MCMEM_RS08780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MCMEM_RS08795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MCMEM_RS08815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MCMEM_RS08825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCMEM_RS08860	COG0590	tRNA wobble adenosine to inosine editing
MCMEM_RS08865	COG0826	peptidase U32
MCMEM_RS08885	COG0543	2 iron, 2 sulfur cluster binding
MCMEM_RS08890	COG0167	dihydroorotate dehydrogenase activity
MCMEM_RS08895	COG0181	hydroxymethylbilane synthase activity
MCMEM_RS08905	COG0113	porphobilinogen synthase activity
MCMEM_RS08910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCMEM_RS08915	COG1648	precorrin-2 dehydrogenase activity
MCMEM_RS08915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCMEM_RS08925	COG1522	sequence-specific DNA binding
MCMEM_RS08930	COG0535	radical SAM domain protein
MCMEM_RS08940	COG0142	geranyltranstransferase activity
MCMEM_RS08945	COG0535	radical SAM domain protein
MCMEM_RS08955	COG1269	ATP hydrolysis coupled proton transport
MCMEM_RS08965	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
MCMEM_RS08985	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MCMEM_RS09045	COG0668	transmembrane transport
MCMEM_RS09080	COG0602	queuosine metabolic process
MCMEM_RS09090	COG2144	transferase activity, transferring acyl groups
MCMEM_RS09095	COG1433	Dinitrogenase iron-molybdenum cofactor
MCMEM_RS09095	COG0535	radical SAM domain protein
MCMEM_RS09105	COG0602	queuosine metabolic process
MCMEM_RS09115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MCMEM_RS09135	COG0189	ligase activity
MCMEM_RS09135	COG4067	protein conserved in archaea
MCMEM_RS09150	COG0585	pseudouridine synthase activity
MCMEM_RS09155	COG0504	CTP synthase activity
MCMEM_RS09180	COG1007	ATP synthesis coupled electron transport
MCMEM_RS09185	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCMEM_RS09195	COG0713	ATP synthesis coupled electron transport
MCMEM_RS09230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCMEM_RS09235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCMEM_RS09255	COG1233	COG1233 Phytoene dehydrogenase and related
MCMEM_RS09260	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCMEM_RS09265	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCMEM_RS09270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCMEM_RS09280	COG1324	tolerance protein
MCMEM_RS09290	COG0644	oxidoreductase
MCMEM_RS09300	COG0569	domain protein
MCMEM_RS09305	COG0484	heat shock protein binding
MCMEM_RS09310	COG0443	Heat shock 70 kDa protein
MCMEM_RS09315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MCMEM_RS09325	COG1181	Belongs to the D-alanine--D-alanine ligase family
MCMEM_RS09350	COG2217	Heavy metal translocating P-type atpase
MCMEM_RS09360	COG2608	mercury ion transmembrane transporter activity
MCMEM_RS09415	COG1518	maintenance of DNA repeat elements
MCMEM_RS09500	COG0310	cobalt ion transport
MCMEM_RS09515	COG1122	ATPase activity
MCMEM_RS09520	COG0301	tRNA thio-modification
MCMEM_RS09535	COG1254	Belongs to the acylphosphatase family
MCMEM_RS09540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCMEM_RS09555	COG0493	'glutamate synthase
MCMEM_RS09575	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MCMEM_RS09580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MCMEM_RS09590	COG0131	Imidazoleglycerol-phosphate dehydratase
MCMEM_RS09595	COG1193	negative regulation of DNA recombination
MCMEM_RS09650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MCMEM_RS09655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCMEM_RS09660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MCMEM_RS09700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MCMEM_RS09710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MCMEM_RS09735	COG2078	PFAM AMMECR1 domain protein
MCMEM_RS09740	COG0126	phosphoglycerate kinase activity
MCMEM_RS09745	COG0857	belongs to the CobB CobQ family
MCMEM_RS09760	COG0038	chloride channel
MCMEM_RS09765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCMEM_RS09770	COG1494	fructose-1,6-bisphosphatase
MCMEM_RS09780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MCMEM_RS09785	COG0495	leucyl-tRNA aminoacylation
MCMEM_RS09825	COG3263	regulation of cellular component size
MCMEM_RS09840	COG5012	cobalamin binding
MCMEM_RS09855	COG5012	cobalamin binding
MCMEM_RS09905	COG2255	four-way junction helicase activity
MCMEM_RS09915	COG2878	Part of a membrane complex involved in electron transport
MCMEM_RS09915	COG1245	4Fe-4S binding domain
MCMEM_RS09920	COG4657	Part of a membrane complex involved in electron transport
MCMEM_RS09925	COG4660	Part of a membrane complex involved in electron transport
MCMEM_RS09930	COG4659	FMN binding
MCMEM_RS09935	COG4658	electron transport chain
MCMEM_RS09940	COG4656	Part of a membrane complex involved in electron transport
MCMEM_RS09955	COG1477	protein flavinylation
MCMEM_RS09960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MCMEM_RS10000	COG1185	polyribonucleotide nucleotidyltransferase activity
MCMEM_RS10025	COG0189	ligase activity
MCMEM_RS10045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MCMEM_RS10050	COG1078	dGTPase activity
MCMEM_RS10060	COG0163	prenyltransferase activity
MCMEM_RS10075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCMEM_RS10085	COG1993	acr, cog1993
MCMEM_RS10100	COG0521	Mo-molybdopterin cofactor biosynthetic process
MCMEM_RS10105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MCMEM_RS10125	COG0180	Tryptophanyl-tRNA synthetase
MCMEM_RS10145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MCMEM_RS10145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCMEM_RS10150	COG1606	tRNA processing
MCMEM_RS10160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MCMEM_RS10170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCMEM_RS10210	COG0714	Associated with various cellular activities
MCMEM_RS10315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCMEM_RS10355	COG1739	Uncharacterized protein family UPF0029
MCMEM_RS10360	COG0667	Aldo Keto reductase
MCMEM_RS10395	COG2878	Part of a membrane complex involved in electron transport
MCMEM_RS10410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MCMEM_RS10425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MCMEM_RS10445	COG0322	excinuclease ABC activity
MCMEM_RS10450	COG0493	'glutamate synthase
MCMEM_RS10450	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MCMEM_RS10460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCMEM_RS10490	COG0577	efflux transmembrane transporter activity
MCMEM_RS10490	COG1136	(ABC) transporter
MCMEM_RS10495	COG1136	(ABC) transporter
MCMEM_RS10505	COG0589	response to stress
MCMEM_RS10560	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MCMEM_RS10565	COG2048	Heterodisulfide reductase, subunit B
MCMEM_RS10570	COG0247	lactate metabolic process
MCMEM_RS10570	COG2181	nitrate reductase activity
MCMEM_RS10580	COG0067	glutamate synthase
MCMEM_RS10600	COG1570	exodeoxyribonuclease VII activity
MCMEM_RS10605	COG1722	exodeoxyribonuclease VII activity
MCMEM_RS10640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MCMEM_RS10685	COG0420	3'-5' exonuclease activity
MCMEM_RS10690	COG1196	nuclear chromosome segregation
MCMEM_RS10700	COG1196	nuclear chromosome segregation
MCMEM_RS10710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MCMEM_RS10720	COG1216	Glycosyl transferase, family 2
MCMEM_RS10725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MCMEM_RS10735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MCMEM_RS10750	COG1733	regulation of RNA biosynthetic process
MCMEM_RS10755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCMEM_RS10785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MCMEM_RS10815	COG0537	adenosine 5'-monophosphoramidase activity
MCMEM_RS10830	COG0494	nUDIX hydrolase
MCMEM_RS10845	COG2205	protein histidine kinase activity
MCMEM_RS10845	COG5002	protein histidine kinase activity
MCMEM_RS10845	COG0784	Response regulator, receiver
MCMEM_RS10855	COG5002	protein histidine kinase activity
MCMEM_RS10865	COG5012	cobalamin binding
MCMEM_RS10870	COG0145	ligase activity
MCMEM_RS10890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCMEM_RS10900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCMEM_RS10905	COG0303	'Molybdopterin
MCMEM_RS10975	COG0784	Response regulator, receiver
MCMEM_RS10985	COG4451	ribulose bisphosphate carboxylase, small
MCMEM_RS10985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MCMEM_RS10990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCMEM_RS11010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MCMEM_RS11040	COG0528	UMP kinase activity
MCMEM_RS11060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MCMEM_RS11075	COG0473	3-isopropylmalate dehydrogenase activity
MCMEM_RS11085	COG0066	3-isopropylmalate dehydratase activity
MCMEM_RS11090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCMEM_RS11105	COG0438	transferase activity, transferring glycosyl groups
MCMEM_RS11145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MCMEM_RS11150	COG1091	dTDP-4-dehydrorhamnose reductase activity
MCMEM_RS11175	COG0438	transferase activity, transferring glycosyl groups
MCMEM_RS11190	COG0367	asparagine synthase
MCMEM_RS11195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCMEM_RS11200	COG0438	transferase activity, transferring glycosyl groups
MCMEM_RS11205	COG0463	Glycosyl transferase, family 2
MCMEM_RS11210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCMEM_RS11230	COG0024	Methionine aminopeptidase
MCMEM_RS11245	COG2226	methyltransferase
MCMEM_RS11255	COG0101	tRNA pseudouridine synthase activity
MCMEM_RS11285	COG0066	3-isopropylmalate dehydratase activity
MCMEM_RS11290	COG0473	3-isopropylmalate dehydrogenase activity
MCMEM_RS11300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCMEM_RS11325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCMEM_RS11340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCMEM_RS11345	COG0154	amidase activity
MCMEM_RS11350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCMEM_RS11375	COG1151	hydroxylamine reductase activity
MCMEM_RS11405	COG3118	belongs to the thioredoxin family
MCMEM_RS11420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MCMEM_RS11430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MCMEM_RS11435	COG1891	lyase activity
MCMEM_RS11440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCMEM_RS11445	COG1458	PINc domain ribonuclease
MCMEM_RS11455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MCMEM_RS11460	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MCMEM_RS11465	COG0157	Belongs to the NadC ModD family
MCMEM_RS11490	COG0148	phosphopyruvate hydratase activity
MCMEM_RS11495	COG0417	DNA replication proofreading
MCMEM_RS11515	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCMEM_RS11520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MCMEM_RS11540	COG0475	glutathione-regulated potassium exporter activity
MCMEM_RS11545	COG0517	IMP dehydrogenase activity
MCMEM_RS11545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCMEM_RS11545	COG0617	tRNA 3'-terminal CCA addition
MCMEM_RS11550	COG1122	ATPase activity
MCMEM_RS11560	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MCMEM_RS11565	COG0310	cobalt ion transport
MCMEM_RS11575	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MCMEM_RS11580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MCMEM_RS11585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MCMEM_RS11605	COG2373	Large extracellular alpha-helical protein
MCMEM_RS11630	COG0842	Transport permease protein
MCMEM_RS11645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCMEM_RS11645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCMEM_RS11655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCMEM_RS11670	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MCMEM_RS11690	COG0076	glutamate decarboxylase activity
MCMEM_RS11700	COG2205	protein histidine kinase activity
MCMEM_RS11700	COG2202	Pas domain
MCMEM_RS11710	COG2205	protein histidine kinase activity
MCMEM_RS11750	COG5297	Belongs to the glycosyl hydrolase family 6
MCMEM_RS11750	COG4733	cellulase activity
MCMEM_RS11770	COG2205	protein histidine kinase activity
MCMEM_RS11780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MCMEM_RS11785	COG1404	Belongs to the peptidase S8 family
MCMEM_RS11800	COG2205	protein histidine kinase activity
MCMEM_RS11840	COG0784	Response regulator, receiver
MCMEM_RS11840	COG2198	Histidine kinase
MCMEM_RS11840	COG5002	protein histidine kinase activity
MCMEM_RS11845	COG2205	protein histidine kinase activity
MCMEM_RS11895	COG5002	protein histidine kinase activity
MCMEM_RS11895	COG0784	Response regulator, receiver
MCMEM_RS11895	COG2198	Histidine kinase
MCMEM_RS11900	COG5002	protein histidine kinase activity
MCMEM_RS11910	COG2205	protein histidine kinase activity
MCMEM_RS11935	COG1234	tRNA 3'-trailer cleavage
MCMEM_RS12000	COG5002	protein histidine kinase activity
MCMEM_RS12005	COG1401	restriction endodeoxyribonuclease activity