locus-tag	class	description
B5K38_RS00030	COG0674	pyruvate-flavodoxin oxidoreductase activity
B5K38_RS00030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B5K38_RS00045	COG1465	3-dehydroquinate synthase
B5K38_RS00075	COG1832	CoA-binding protein
B5K38_RS00080	COG0165	Argininosuccinate lyase
B5K38_RS00085	COG0585	pseudouridine synthase activity
B5K38_RS00100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5K38_RS00115	COG0864	Transcriptional regulator
B5K38_RS00135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5K38_RS00145	COG4974	Belongs to the 'phage' integrase family
B5K38_RS00280	COG0393	Putative heavy-metal-binding
B5K38_RS00315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5K38_RS00320	COG1797	cobyrinic acid a,c-diamide synthase activity
B5K38_RS00355	COG1469	GTP cyclohydrolase I activity
B5K38_RS00360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5K38_RS00400	COG1304	FMN binding
B5K38_RS00420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5K38_RS00435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5K38_RS00440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5K38_RS00440	COG0140	phosphoribosyl-ATP diphosphatase activity
B5K38_RS00450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B5K38_RS00455	COG2264	protein methyltransferase activity
B5K38_RS00465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B5K38_RS00470	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B5K38_RS00475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5K38_RS00500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5K38_RS00505	COG0347	Belongs to the P(II) protein family
B5K38_RS00510	COG0004	ammonium transporteR
B5K38_RS00515	COG0347	Belongs to the P(II) protein family
B5K38_RS00525	COG0004	ammonium transporteR
B5K38_RS00575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5K38_RS00590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5K38_RS00595	COG0067	glutamate synthase
B5K38_RS00645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B5K38_RS00655	COG0438	transferase activity, transferring glycosyl groups
B5K38_RS00685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5K38_RS00690	COG1396	sequence-specific DNA binding
B5K38_RS00695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5K38_RS00705	COG0475	glutathione-regulated potassium exporter activity
B5K38_RS00715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5K38_RS00720	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B5K38_RS00785	COG1840	ABC-type Fe3 transport system, periplasmic component
B5K38_RS00795	COG3842	ATPase activity
B5K38_RS00805	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B5K38_RS00825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B5K38_RS00835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5K38_RS00840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B5K38_RS00840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B5K38_RS00860	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B5K38_RS00875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5K38_RS00910	COG0517	IMP dehydrogenase activity
B5K38_RS00910	COG0516	GMP reductase activity
B5K38_RS00920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B5K38_RS00925	COG0066	3-isopropylmalate dehydratase activity
B5K38_RS00945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B5K38_RS00970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5K38_RS00975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5K38_RS00980	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B5K38_RS00985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5K38_RS00990	COG0275	rRNA processing
B5K38_RS01005	COG0471	metal ion transport
B5K38_RS01005	COG0490	domain, Protein
B5K38_RS01010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5K38_RS01035	COG0482	sulfurtransferase activity
B5K38_RS01050	COG2045	Belongs to the ComB family
B5K38_RS01060	COG0003	Pfam Anion-transporting ATPase
B5K38_RS01075	COG0534	Mate efflux family protein
B5K38_RS01100	COG0390	transport system, permease component
B5K38_RS01115	COG1078	dGTPase activity
B5K38_RS01125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5K38_RS01135	COG0047	phosphoribosylformylglycinamidine synthase activity
B5K38_RS01155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5K38_RS01155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5K38_RS01165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B5K38_RS01175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B5K38_RS01240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5K38_RS01245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5K38_RS01250	COG1120	ATPase activity
B5K38_RS01265	COG0303	'Molybdopterin
B5K38_RS01280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5K38_RS01285	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5K38_RS01290	COG4149	molybdate abc transporter
B5K38_RS01295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B5K38_RS01300	COG0667	Aldo Keto reductase
B5K38_RS01305	COG1396	sequence-specific DNA binding
B5K38_RS01310	COG0697	spore germination
B5K38_RS01320	COG0423	glycine-tRNA ligase activity
B5K38_RS01330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5K38_RS01340	COG2217	Heavy metal translocating P-type atpase
B5K38_RS01345	COG0640	Transcriptional regulator
B5K38_RS01355	COG1227	inorganic diphosphatase activity
B5K38_RS01360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5K38_RS01380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5K38_RS01390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5K38_RS01400	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
B5K38_RS01405	COG1126	abc transporter atp-binding protein
B5K38_RS01410	COG3481	metal-dependent phosphohydrolase, HD sub domain
B5K38_RS01525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5K38_RS01525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5K38_RS01535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5K38_RS01555	COG0081	regulation of translation
B5K38_RS01575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5K38_RS01580	COG0668	transmembrane transport
B5K38_RS01590	COG2095	MarC family integral membrane protein
B5K38_RS01605	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B5K38_RS01620	COG1136	(ABC) transporter
B5K38_RS01625	COG1809	phosphosulfolactate synthase activity
B5K38_RS01650	COG0617	tRNA 3'-terminal CCA addition
B5K38_RS01650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B5K38_RS01650	COG0517	IMP dehydrogenase activity
B5K38_RS01660	COG0140	phosphoribosyl-ATP diphosphatase activity
B5K38_RS01660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5K38_RS01665	COG4956	integral membrane protein (PIN domain superfamily)
B5K38_RS01670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B5K38_RS01675	COG0105	UTP biosynthetic process
B5K38_RS01680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5K38_RS01695	COG2239	Acts as a magnesium transporter
B5K38_RS01705	COG0409	Hydrogenase expression formation protein
B5K38_RS01735	COG0083	homoserine kinase activity
B5K38_RS01785	COG1013	pyruvate-flavodoxin oxidoreductase activity
B5K38_RS01800	COG0425	Belongs to the sulfur carrier protein TusA family
B5K38_RS01845	COG1980	fructose-bisphosphate aldolase activity
B5K38_RS01850	COG0129	dihydroxy-acid dehydratase activity
B5K38_RS01865	COG0083	homoserine kinase activity
B5K38_RS01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5K38_RS01950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B5K38_RS01970	COG5016	pyruvate
B5K38_RS01970	COG0511	ligase activity, forming carbon-carbon bonds
B5K38_RS01975	COG0439	Biotin carboxylase
B5K38_RS02000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5K38_RS02005	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
B5K38_RS02015	COG1584	GPR1 FUN34 yaaH family protein
B5K38_RS02025	COG2860	membrane
B5K38_RS02045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5K38_RS02060	COG0402	S-adenosylhomocysteine deaminase activity
B5K38_RS02075	COG0066	3-isopropylmalate dehydratase activity
B5K38_RS02080	COG1121	(ABC) transporter
B5K38_RS02110	COG0528	UMP kinase activity
B5K38_RS02140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5K38_RS02145	COG0151	Belongs to the GarS family
B5K38_RS02155	COG1587	Uroporphyrinogen-III synthase
B5K38_RS02165	COG0148	phosphopyruvate hydratase activity
B5K38_RS02170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5K38_RS02180	COG0501	Belongs to the peptidase M48B family
B5K38_RS02205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B5K38_RS02220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5K38_RS02220	COG0517	IMP dehydrogenase activity
B5K38_RS02235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B5K38_RS02245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5K38_RS02250	COG3290	protein histidine kinase activity
B5K38_RS02250	COG0840	transmembrane signaling receptor activity
B5K38_RS02255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5K38_RS02260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5K38_RS02275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5K38_RS02280	COG0733	neurotransmitter:sodium symporter activity
B5K38_RS02290	COG0617	tRNA 3'-terminal CCA addition
B5K38_RS02290	COG0517	IMP dehydrogenase activity
B5K38_RS02290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B5K38_RS02320	COG0778	Nitroreductase
B5K38_RS02345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5K38_RS02350	COG0084	hydrolase, TatD family'
B5K38_RS02360	COG2155	Conserved Protein
B5K38_RS02370	COG0189	ligase activity
B5K38_RS02375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B5K38_RS02385	COG0167	dihydroorotate dehydrogenase activity
B5K38_RS02390	COG0539	negative regulation of cytoplasmic translation
B5K38_RS02435	COG2894	cell division
B5K38_RS02475	COG0513	Belongs to the DEAD box helicase family
B5K38_RS02670	COG1120	ATPase activity
B5K38_RS02680	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B5K38_RS02685	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B5K38_RS02720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5K38_RS02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5K38_RS02785	COG1429	ligase activity, forming nitrogen-metal bonds
B5K38_RS02790	COG1111	helicase
B5K38_RS02790	COG1205	dead DEAH box helicase
B5K38_RS02800	COG0069	glutamate synthase activity
B5K38_RS02835	COG3842	ATPase activity
B5K38_RS02850	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5K38_RS02860	COG1229	Formylmethanofuran dehydrogenase subunit A
B5K38_RS02880	COG0303	'Molybdopterin
B5K38_RS02885	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5K38_RS02890	COG4149	molybdate abc transporter
B5K38_RS02920	COG1136	(ABC) transporter
B5K38_RS02920	COG0577	efflux transmembrane transporter activity
B5K38_RS02930	COG1136	(ABC) transporter
B5K38_RS02960	COG0659	secondary active sulfate transmembrane transporter activity
B5K38_RS02990	COG0668	transmembrane transport
B5K38_RS03005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5K38_RS03020	COG0473	3-isopropylmalate dehydrogenase activity
B5K38_RS03025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5K38_RS03050	COG0303	'Molybdopterin
B5K38_RS03055	COG2078	PFAM AMMECR1 domain protein
B5K38_RS03065	COG0131	Imidazoleglycerol-phosphate dehydratase
B5K38_RS03075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5K38_RS03080	COG0765	amino acid transport
B5K38_RS03095	COG2813	Specifically methylates the guanine in position
B5K38_RS03120	COG0693	protein deglycase activity
B5K38_RS03125	COG2890	protein-(glutamine-N5) methyltransferase activity
B5K38_RS03160	COG0318	PFAM AMP-dependent synthetase and ligase
B5K38_RS03185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5K38_RS03195	COG0746	molybdenum cofactor guanylyltransferase activity
B5K38_RS03225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B5K38_RS03235	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B5K38_RS03245	COG0525	valine-tRNA ligase activity
B5K38_RS03250	COG0589	response to stress
B5K38_RS03275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5K38_RS03280	COG1215	transferase activity, transferring glycosyl groups
B5K38_RS03355	COG1185	polyribonucleotide nucleotidyltransferase activity
B5K38_RS03360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B5K38_RS03380	COG0343	queuine tRNA-ribosyltransferase activity
B5K38_RS03390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B5K38_RS03400	COG3527	Alpha-acetolactate decarboxylase
B5K38_RS03410	COG0585	pseudouridine synthase activity
B5K38_RS03430	COG1342	Belongs to the UPF0251 family
B5K38_RS03435	COG1125	glycine betaine transport
B5K38_RS03435	COG0517	IMP dehydrogenase activity
B5K38_RS03465	COG1102	Psort location Cytoplasmic, score
B5K38_RS03485	COG1918	ferrous iron import across plasma membrane
B5K38_RS03485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B5K38_RS03495	COG1321	iron dependent repressor
B5K38_RS03510	COG0577	efflux transmembrane transporter activity
B5K38_RS03560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B5K38_RS03565	COG0039	L-malate dehydrogenase activity
B5K38_RS03580	COG0430	RNA-3'-phosphate cyclase activity
B5K38_RS03585	COG2192	nodulation
B5K38_RS03590	COG0028	Belongs to the TPP enzyme family
B5K38_RS03595	COG0440	acetolactate synthase activity
B5K38_RS03605	COG0385	Bile acid
B5K38_RS03630	COG0535	radical SAM domain protein
B5K38_RS03630	COG1433	Dinitrogenase iron-molybdenum cofactor
B5K38_RS03635	COG0826	peptidase U32
B5K38_RS03640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5K38_RS03655	COG0659	secondary active sulfate transmembrane transporter activity
B5K38_RS03675	COG0052	Belongs to the universal ribosomal protein uS2 family
B5K38_RS03690	COG0697	spore germination
B5K38_RS03695	COG4895	conserved protein (DUF2196)
B5K38_RS03710	COG1476	TRANSCRIPTIONal
B5K38_RS03735	COG1757	Na H antiporter
B5K38_RS03755	COG0552	protein localization to endoplasmic reticulum
B5K38_RS03760	COG0071	Belongs to the small heat shock protein (HSP20) family
B5K38_RS03765	COG2264	protein methyltransferase activity
B5K38_RS03770	COG1830	Aldolase
B5K38_RS03775	COG0149	triose-phosphate isomerase activity
B5K38_RS03780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5K38_RS03790	COG0348	domain, Protein
B5K38_RS03810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5K38_RS03815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B5K38_RS03820	COG0442	prolyl-tRNA aminoacylation
B5K38_RS03825	COG0495	leucyl-tRNA aminoacylation
B5K38_RS03835	COG0534	Mate efflux family protein
B5K38_RS03850	COG0189	ligase activity
B5K38_RS03860	COG0489	protein tyrosine kinase activity
B5K38_RS03870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5K38_RS03880	COG1891	lyase activity
B5K38_RS03900	COG0598	Magnesium transport protein CorA
B5K38_RS03905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5K38_RS03920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B5K38_RS03940	COG0864	Transcriptional regulator
B5K38_RS03945	COG1151	hydroxylamine reductase activity
B5K38_RS03955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5K38_RS03980	COG0556	nucleotide-excision repair
B5K38_RS03985	COG0322	excinuclease ABC activity
B5K38_RS04000	COG1722	exodeoxyribonuclease VII activity
B5K38_RS04005	COG1570	exodeoxyribonuclease VII activity
B5K38_RS04035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5K38_RS04135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B5K38_RS04170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5K38_RS04210	COG1401	restriction endodeoxyribonuclease activity
B5K38_RS04210	COG1401	restriction endodeoxyribonuclease activity
B5K38_RS04220	COG3177	Filamentation induced by cAMP protein fic
B5K38_RS04320	COG4974	Belongs to the 'phage' integrase family
B5K38_RS04385	COG1691	(AIR) carboxylase
B5K38_RS04390	COG0667	Aldo Keto reductase
B5K38_RS04415	COG0667	Aldo Keto reductase
B5K38_RS04440	COG1309	transcriptional regulator
B5K38_RS04480	COG1309	transcriptional regulator
B5K38_RS04490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5K38_RS04530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5K38_RS04540	COG3259	Nickel-dependent hydrogenase
B5K38_RS04550	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B5K38_RS04555	COG3259	Nickel-dependent hydrogenase
B5K38_RS04565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B5K38_RS04570	COG0243	molybdopterin cofactor binding
B5K38_RS04590	COG5012	cobalamin binding
B5K38_RS04595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5K38_RS04600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5K38_RS04605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5K38_RS04610	COG0523	cobalamin synthesis protein
B5K38_RS04625	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
B5K38_RS04630	COG0328	RNA-DNA hybrid ribonuclease activity
B5K38_RS04630	COG3341	Caulimovirus viroplasmin
B5K38_RS04710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5K38_RS04715	COG1280	lysine exporter protein (LysE YggA)
B5K38_RS04740	COG0347	Belongs to the P(II) protein family
B5K38_RS04745	COG0347	Belongs to the P(II) protein family
B5K38_RS04755	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B5K38_RS04775	COG1509	lysine 2,3-aminomutase activity
B5K38_RS04790	COG0475	glutathione-regulated potassium exporter activity
B5K38_RS04795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5K38_RS04800	COG2113	Glycine betaine
B5K38_RS04805	COG4176	ABC-type proline glycine betaine transport system permease component
B5K38_RS04830	COG0590	tRNA wobble adenosine to inosine editing
B5K38_RS04835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5K38_RS04840	COG0577	efflux transmembrane transporter activity
B5K38_RS04845	COG0181	hydroxymethylbilane synthase activity
B5K38_RS04865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B5K38_RS04885	COG0473	3-isopropylmalate dehydrogenase activity
B5K38_RS04915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B5K38_RS04930	COG0310	cobalt ion transport
B5K38_RS04945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5K38_RS04950	COG0504	CTP synthase activity
B5K38_RS04955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5K38_RS04955	COG0519	Catalyzes the synthesis of GMP from XMP
B5K38_RS04970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B5K38_RS04985	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B5K38_RS04990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5K38_RS05015	COG1234	tRNA 3'-trailer cleavage
B5K38_RS05030	COG1238	metal cluster binding
B5K38_RS05060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5K38_RS05070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5K38_RS05075	COG0367	asparagine synthase
B5K38_RS05080	COG0543	2 iron, 2 sulfur cluster binding
B5K38_RS05085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B5K38_RS05100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5K38_RS05110	COG0835	chemotaxis
B5K38_RS05115	COG2201	protein-glutamate methylesterase activity
B5K38_RS05120	COG0643	Histidine kinase
B5K38_RS05120	COG2198	Histidine kinase
B5K38_RS05125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B5K38_RS05135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5K38_RS05150	COG2201	protein-glutamate methylesterase activity
B5K38_RS05165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5K38_RS05175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5K38_RS05190	COG0175	sulfate reduction
B5K38_RS05195	COG0730	response to heat
B5K38_RS05200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5K38_RS05200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B5K38_RS05215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5K38_RS05220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5K38_RS05240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B5K38_RS05310	COG1518	maintenance of DNA repeat elements
B5K38_RS05340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B5K38_RS05380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5K38_RS05415	COG1793	dna ligase
B5K38_RS05420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5K38_RS05505	COG2264	protein methyltransferase activity
B5K38_RS05585	COG0159	tryptophan synthase activity
B5K38_RS05590	COG0133	tryptophan synthase activity
B5K38_RS05595	COG0135	phosphoribosylanthranilate isomerase activity
B5K38_RS05600	COG0512	Glutamine amidotransferase of anthranilate synthase
B5K38_RS05605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5K38_RS05620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5K38_RS05625	COG0564	pseudouridine synthase activity
B5K38_RS05630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5K38_RS05635	COG0708	Exodeoxyribonuclease III
B5K38_RS05640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5K38_RS05655	COG0517	IMP dehydrogenase activity
B5K38_RS05655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5K38_RS05665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5K38_RS05705	COG0018	arginyl-trna synthetase
B5K38_RS05750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5K38_RS05775	COG1269	ATP hydrolysis coupled proton transport
B5K38_RS05790	COG1527	subunit (C
B5K38_RS05805	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
B5K38_RS05810	COG1394	ATPase activity, coupled to movement of substances
B5K38_RS05835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5K38_RS05845	COG2048	Heterodisulfide reductase, subunit B
B5K38_RS05875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B5K38_RS05885	COG1739	Uncharacterized protein family UPF0029
B5K38_RS05895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5K38_RS05915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5K38_RS05935	COG0616	signal peptide processing
B5K38_RS05950	COG0436	Aminotransferase
B5K38_RS05970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B5K38_RS05975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5K38_RS05985	COG0662	Cupin 2, conserved barrel domain protein
B5K38_RS05985	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B5K38_RS05990	COG0438	transferase activity, transferring glycosyl groups
B5K38_RS06020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5K38_RS06025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B5K38_RS06040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5K38_RS06040	COG0574	Belongs to the PEP-utilizing enzyme family
B5K38_RS06050	COG0573	inorganic phosphate transmembrane transporter activity
B5K38_RS06055	COG0581	inorganic phosphate transmembrane transporter activity
B5K38_RS06060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5K38_RS06065	COG0704	Plays a role in the regulation of phosphate uptake
B5K38_RS06075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5K38_RS06090	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B5K38_RS06135	COG3958	Transketolase
B5K38_RS06140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5K38_RS06145	COG3959	Transketolase, thiamine diphosphate binding domain
B5K38_RS06165	COG0697	spore germination
B5K38_RS06175	COG1418	mRNA catabolic process
B5K38_RS06180	COG0012	GTP binding
B5K38_RS06185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5K38_RS06190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B5K38_RS06200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5K38_RS06200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5K38_RS06205	COG2183	response to ionizing radiation
B5K38_RS06210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5K38_RS06215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5K38_RS06220	COG0432	Pfam Uncharacterised protein family UPF0047
B5K38_RS06235	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B5K38_RS06240	COG0426	domain, Protein
B5K38_RS06245	COG0426	domain, Protein
B5K38_RS06250	COG1773	rubredoxin
B5K38_RS06250	COG1592	Rubrerythrin
B5K38_RS06255	COG1522	sequence-specific DNA binding
B5K38_RS06260	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B5K38_RS06265	COG0352	thiamine-phosphate diphosphorylase activity
B5K38_RS06275	COG1201	RNA secondary structure unwinding
B5K38_RS06290	COG1968	undecaprenyl-diphosphatase activity
B5K38_RS06295	COG2894	cell division
B5K38_RS06305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5K38_RS06320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5K38_RS06330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B5K38_RS06330	COG3261	NADH dehydrogenase
B5K38_RS06340	COG2048	Heterodisulfide reductase, subunit B
B5K38_RS06350	COG2033	superoxide reductase activity
B5K38_RS06360	COG1528	Iron-storage protein
B5K38_RS06375	COG0426	domain, Protein
B5K38_RS06385	COG2608	mercury ion transmembrane transporter activity
B5K38_RS06390	COG2217	Heavy metal translocating P-type atpase
B5K38_RS06400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5K38_RS06405	COG0396	ATPase activity
B5K38_RS06410	COG0719	Fe-S assembly protein
B5K38_RS06410	COG1372	Participates in initiation and elongation during chromosome replication
B5K38_RS06415	COG0463	Glycosyl transferase, family 2
B5K38_RS06420	COG1183	phosphatidylcholine synthase activity
B5K38_RS06435	COG0450	alkyl hydroperoxide reductase
B5K38_RS06455	COG2226	methyltransferase
B5K38_RS06470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5K38_RS06475	COG1120	ATPase activity
B5K38_RS06490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5K38_RS06495	COG0235	Class ii aldolase
B5K38_RS06505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B5K38_RS06510	COG1047	Peptidyl-prolyl cis-trans
B5K38_RS06515	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
B5K38_RS06545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5K38_RS06560	COG0019	diaminopimelate decarboxylase activity
B5K38_RS06580	COG0006	proline dipeptidase activity
B5K38_RS06585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5K38_RS06590	COG0174	glutamine synthetase
B5K38_RS06615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5K38_RS06620	COG0183	Belongs to the thiolase family
B5K38_RS06635	COG1492	cobalamin metabolic process
B5K38_RS06680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5K38_RS06685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5K38_RS06720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5K38_RS06725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5K38_RS06730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5K38_RS06735	COG0314	molybdopterin synthase activity
B5K38_RS06750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5K38_RS06755	COG1606	tRNA processing
B5K38_RS06800	COG1229	Formylmethanofuran dehydrogenase subunit A
B5K38_RS06815	COG0517	IMP dehydrogenase activity
B5K38_RS06820	COG0517	IMP dehydrogenase activity
B5K38_RS06830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5K38_RS06845	COG0113	porphobilinogen synthase activity
B5K38_RS06880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5K38_RS06880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5K38_RS06885	COG0252	asparaginase activity
B5K38_RS06915	COG0674	pyruvate-flavodoxin oxidoreductase activity
B5K38_RS06915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B5K38_RS06925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5K38_RS06940	COG1053	succinate dehydrogenase
B5K38_RS06950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5K38_RS07020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5K38_RS07040	COG0297	glycogen (starch) synthase activity
B5K38_RS07045	COG0166	Belongs to the GPI family
B5K38_RS07065	COG0288	reversible hydration of carbon dioxide
B5K38_RS07075	COG2116	formate transmembrane transporter activity
B5K38_RS07090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5K38_RS07125	COG1185	polyribonucleotide nucleotidyltransferase activity
B5K38_RS07160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5K38_RS07165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5K38_RS07180	COG0200	Binds to the 23S rRNA
B5K38_RS07185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5K38_RS07210	COG0148	phosphopyruvate hydratase activity
B5K38_RS07230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5K38_RS07235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5K38_RS07240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B5K38_RS07265	COG2890	protein-(glutamine-N5) methyltransferase activity
B5K38_RS07275	COG0419	ATPase involved in DNA repair
B5K38_RS07295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5K38_RS07310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5K38_RS07310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5K38_RS07330	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B5K38_RS07335	COG0037	tRNA processing
B5K38_RS07345	COG0301	tRNA thio-modification
B5K38_RS07355	COG0037	tRNA processing
B5K38_RS07370	COG0517	IMP dehydrogenase activity
B5K38_RS07370	COG0516	GMP reductase activity
B5K38_RS07385	COG0085	RNA polymerase activity
B5K38_RS07390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5K38_RS07395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5K38_RS07415	COG0049	tRNA binding
B5K38_RS07420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5K38_RS07425	COG2895	sulfate adenylyltransferase (ATP) activity
B5K38_RS07435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5K38_RS07450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B5K38_RS07455	COG1983	PspC domain protein
B5K38_RS07465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5K38_RS07470	COG0402	S-adenosylhomocysteine deaminase activity
B5K38_RS07475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5K38_RS07490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5K38_RS07505	COG1355	regulation of microtubule-based process
B5K38_RS07535	COG0710	3-dehydroquinate dehydratase activity
B5K38_RS07540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5K38_RS07545	COG0436	Aminotransferase
B5K38_RS07550	COG1196	nuclear chromosome segregation
B5K38_RS07555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5K38_RS07560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5K38_RS07590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5K38_RS07595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5K38_RS07600	COG0255	Belongs to the universal ribosomal protein uL29 family
B5K38_RS07615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5K38_RS07620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5K38_RS07625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5K38_RS07635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5K38_RS07645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5K38_RS07650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5K38_RS07680	COG0200	Binds to the 23S rRNA
B5K38_RS07690	COG0201	protein transport
B5K38_RS07695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5K38_RS07710	COG0717	Belongs to the dCTP deaminase family
B5K38_RS07715	COG2848	UPF0210 protein
B5K38_RS07730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5K38_RS07740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5K38_RS07760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5K38_RS07770	COG2340	Cysteine-rich secretory protein family
B5K38_RS07775	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B5K38_RS07790	COG0640	Transcriptional regulator
B5K38_RS07795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5K38_RS07800	COG0024	Methionine aminopeptidase
B5K38_RS07805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5K38_RS07805	COG0519	Catalyzes the synthesis of GMP from XMP
B5K38_RS07885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5K38_RS07890	COG0649	NAD binding
B5K38_RS07910	COG2239	Acts as a magnesium transporter
B5K38_RS07920	COG3681	Belongs to the UPF0597 family
B5K38_RS07925	COG1863	multisubunit Na H antiporter MnhE subunit
B5K38_RS07930	COG1730	sister chromatid segregation
B5K38_RS07945	COG1458	PINc domain ribonuclease
B5K38_RS07955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B5K38_RS07970	COG1797	cobyrinic acid a,c-diamide synthase activity
B5K38_RS07980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5K38_RS07985	COG0310	cobalt ion transport
B5K38_RS08005	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5K38_RS08010	COG0668	transmembrane transport
B5K38_RS08015	COG1012	belongs to the aldehyde dehydrogenase family
B5K38_RS08025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5K38_RS08030	COG0529	Catalyzes the synthesis of activated sulfate
B5K38_RS08035	COG0402	S-adenosylhomocysteine deaminase activity
B5K38_RS08040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5K38_RS08055	COG1242	4 iron, 4 sulfur cluster binding
B5K38_RS08080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5K38_RS08095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5K38_RS08100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5K38_RS08105	COG1013	pyruvate-flavodoxin oxidoreductase activity
B5K38_RS08110	COG0674	pyruvate-flavodoxin oxidoreductase activity
B5K38_RS08120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B5K38_RS08145	COG0154	amidase activity
B5K38_RS08155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5K38_RS08165	COG1605	Chorismate mutase
B5K38_RS08165	COG0287	Prephenate dehydrogenase
B5K38_RS08170	COG0459	protein refolding
B5K38_RS08180	COG0704	Plays a role in the regulation of phosphate uptake
B5K38_RS08195	COG3842	ATPase activity
B5K38_RS08220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5K38_RS08225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5K38_RS08230	COG0312	modulator of DNA gyrase
B5K38_RS08235	COG0571	ribonuclease III activity
B5K38_RS08245	COG0436	Aminotransferase
B5K38_RS08250	COG1605	Chorismate mutase
B5K38_RS08250	COG0077	Prephenate dehydratase
B5K38_RS08265	COG2144	transferase activity, transferring acyl groups
B5K38_RS08325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5K38_RS08340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5K38_RS08345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5K38_RS08350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B5K38_RS08370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5K38_RS08375	COG0163	prenyltransferase activity
B5K38_RS08380	COG0778	Nitroreductase
B5K38_RS08465	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
B5K38_RS08480	COG0084	hydrolase, TatD family'
B5K38_RS08495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B5K38_RS08500	COG0156	8-amino-7-oxononanoate synthase activity
B5K38_RS08505	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B5K38_RS08515	COG1056	cytidyltransferase-related domain
B5K38_RS08515	COG1051	belongs to the nudix hydrolase family
B5K38_RS08530	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
B5K38_RS08540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B5K38_RS08545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B5K38_RS08550	COG0010	Belongs to the arginase family
B5K38_RS08565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5K38_RS08570	COG0505	Belongs to the CarA family
B5K38_RS08575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5K38_RS08625	COG0569	domain protein
B5K38_RS08630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B5K38_RS08635	COG2264	protein methyltransferase activity
B5K38_RS08655	COG0469	pyruvate kinase activity
B5K38_RS08675	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
B5K38_RS08700	COG0124	histidyl-tRNA synthetase
B5K38_RS08705	COG2151	metal-sulfur cluster biosynthetic enzyme
B5K38_RS08710	COG0017	Asparaginyl-tRNA synthetase
B5K38_RS08715	COG2119	membrane
B5K38_RS08720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B5K38_RS08725	COG0303	'Molybdopterin
B5K38_RS08770	COG0651	ATP synthesis coupled electron transport
B5K38_RS08775	COG1006	Multisubunit Na H antiporter MnhC subunit
B5K38_RS08780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5K38_RS08785	COG0671	phosphoesterase, PA-phosphatase related
B5K38_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5K38_RS08830	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
B5K38_RS08865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5K38_RS08875	COG3842	ATPase activity
B5K38_RS08885	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5K38_RS08890	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5K38_RS08905	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B5K38_RS08950	COG0540	Belongs to the ATCase OTCase family
B5K38_RS09055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B5K38_RS09060	COG0175	sulfate reduction
B5K38_RS09095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5K38_RS09110	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
B5K38_RS09110	COG0028	Belongs to the TPP enzyme family
B5K38_RS09135	COG3259	Nickel-dependent hydrogenase
B5K38_RS09140	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B5K38_RS09165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5K38_RS09175	COG0460	homoserine dehydrogenase
B5K38_RS09200	COG1185	polyribonucleotide nucleotidyltransferase activity
B5K38_RS09225	COG0583	DNA-binding transcription factor activity
B5K38_RS09240	COG1160	GTP binding
B5K38_RS09270	COG1192	Involved in chromosome partitioning