locus-tag	class	description
MMAH_RS00030	COG0018	arginyl-trna synthetase
MMAH_RS00040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MMAH_RS00060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MMAH_RS00075	COG0516	GMP reductase activity
MMAH_RS00085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MMAH_RS00085	COG0617	tRNA 3'-terminal CCA addition
MMAH_RS00085	COG0517	IMP dehydrogenase activity
MMAH_RS00140	COG0101	tRNA pseudouridine synthase activity
MMAH_RS00150	COG2226	methyltransferase
MMAH_RS00170	COG0024	Methionine aminopeptidase
MMAH_RS00175	COG0006	proline dipeptidase activity
MMAH_RS00205	COG4166	transmembrane transport
MMAH_RS00210	COG2226	methyltransferase
MMAH_RS00215	COG0601	transmembrane transport
MMAH_RS00220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MMAH_RS00225	COG0444	Belongs to the ABC transporter superfamily
MMAH_RS00230	COG4608	Belongs to the ABC transporter superfamily
MMAH_RS00245	COG2252	PERMEase
MMAH_RS00250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MMAH_RS00255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MMAH_RS00260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MMAH_RS00270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MMAH_RS00405	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MMAH_RS00435	COG0438	transferase activity, transferring glycosyl groups
MMAH_RS00440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MMAH_RS00450	COG0438	transferase activity, transferring glycosyl groups
MMAH_RS00540	COG1404	Belongs to the peptidase S8 family
MMAH_RS00545	COG2202	Pas domain
MMAH_RS00545	COG2205	protein histidine kinase activity
MMAH_RS00620	COG4895	conserved protein (DUF2196)
MMAH_RS00630	COG0066	3-isopropylmalate dehydratase activity
MMAH_RS00640	COG0473	3-isopropylmalate dehydrogenase activity
MMAH_RS00650	COG0528	UMP kinase activity
MMAH_RS00655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MMAH_RS00670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MMAH_RS00690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MMAH_RS00700	COG0500	methyltransferase
MMAH_RS00705	COG0138	bifunctional purine biosynthesis protein purh
MMAH_RS00725	COG1139	Iron-sulfur cluster binding protein
MMAH_RS00780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MMAH_RS00785	COG2226	methyltransferase
MMAH_RS00795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MMAH_RS00800	COG1120	ATPase activity
MMAH_RS00805	COG0175	sulfate reduction
MMAH_RS00845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MMAH_RS00845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MMAH_RS00850	COG0616	signal peptide processing
MMAH_RS00860	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MMAH_RS00865	COG1012	belongs to the aldehyde dehydrogenase family
MMAH_RS00880	COG1234	tRNA 3'-trailer cleavage
MMAH_RS00885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MMAH_RS00905	COG0081	regulation of translation
MMAH_RS00945	COG0464	growth
MMAH_RS00955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MMAH_RS00960	COG0012	GTP binding
MMAH_RS00970	COG2205	protein histidine kinase activity
MMAH_RS00970	COG0784	Response regulator, receiver
MMAH_RS00985	COG0459	protein refolding
MMAH_RS00990	COG1268	BioY protein
MMAH_RS00995	COG1122	ATPase activity
MMAH_RS01000	COG1122	ATPase activity
MMAH_RS01005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MMAH_RS01010	COG0145	ligase activity
MMAH_RS01045	COG0347	Belongs to the P(II) protein family
MMAH_RS01050	COG0004	ammonium transporteR
MMAH_RS01060	COG1476	TRANSCRIPTIONal
MMAH_RS01085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MMAH_RS01100	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MMAH_RS01120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MMAH_RS01125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MMAH_RS01130	COG2255	four-way junction helicase activity
MMAH_RS01155	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MMAH_RS01170	COG0287	Prephenate dehydrogenase
MMAH_RS01170	COG1605	Chorismate mutase
MMAH_RS01175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MMAH_RS01185	COG1465	3-dehydroquinate synthase
MMAH_RS01190	COG1830	Aldolase
MMAH_RS01195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MMAH_RS01195	COG0519	Catalyzes the synthesis of GMP from XMP
MMAH_RS01215	COG1846	Transcriptional regulator
MMAH_RS01230	COG0561	phosphatase activity
MMAH_RS01240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MMAH_RS01245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MMAH_RS01275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MMAH_RS01300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MMAH_RS01305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MMAH_RS01335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MMAH_RS01350	COG0489	protein tyrosine kinase activity
MMAH_RS01390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MMAH_RS01395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MMAH_RS01400	COG2202	Pas domain
MMAH_RS01400	COG2205	protein histidine kinase activity
MMAH_RS01415	COG0477	Major facilitator Superfamily
MMAH_RS01425	COG0436	Aminotransferase
MMAH_RS01440	COG1234	tRNA 3'-trailer cleavage
MMAH_RS01450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MMAH_RS01460	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MMAH_RS01475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MMAH_RS01495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MMAH_RS01510	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MMAH_RS01515	COG1078	dGTPase activity
MMAH_RS01520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MMAH_RS01530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MMAH_RS01540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MMAH_RS01545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MMAH_RS01555	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MMAH_RS01580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MMAH_RS01600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MMAH_RS01625	COG0489	protein tyrosine kinase activity
MMAH_RS01630	COG1342	Belongs to the UPF0251 family
MMAH_RS01645	COG0708	Exodeoxyribonuclease III
MMAH_RS01650	COG0459	protein refolding
MMAH_RS01670	COG4175	Glycine betaine
MMAH_RS01670	COG3448	diguanylate cyclase activity
MMAH_RS01680	COG0433	COG0433 Predicted ATPase
MMAH_RS01735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMAH_RS01740	COG0674	pyruvate-flavodoxin oxidoreductase activity
MMAH_RS01745	COG1013	pyruvate-flavodoxin oxidoreductase activity
MMAH_RS01750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MMAH_RS01780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MMAH_RS01790	COG0351	phosphomethylpyrimidine kinase
MMAH_RS01800	COG2095	MarC family integral membrane protein
MMAH_RS01820	COG0745	RESPONSE REGULATOR receiver
MMAH_RS01825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MMAH_RS01845	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MMAH_RS01870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MMAH_RS01875	COG0822	iron-sulfur transferase activity
MMAH_RS01935	COG0688	phosphatidylethanolamine metabolic process
MMAH_RS01940	COG1183	phosphatidylcholine synthase activity
MMAH_RS01945	COG0542	response to heat
MMAH_RS01950	COG0459	protein refolding
MMAH_RS01955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MMAH_RS01965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MMAH_RS01970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MMAH_RS01975	COG2255	four-way junction helicase activity
MMAH_RS01990	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MMAH_RS02000	COG0129	dihydroxy-acid dehydratase activity
MMAH_RS02010	COG1047	Peptidyl-prolyl cis-trans
MMAH_RS02030	COG0426	domain, Protein
MMAH_RS02075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MMAH_RS02085	COG0589	response to stress
MMAH_RS02125	COG0784	Response regulator, receiver
MMAH_RS02125	COG2205	protein histidine kinase activity
MMAH_RS02135	COG1047	Peptidyl-prolyl cis-trans
MMAH_RS02140	COG2202	Pas domain
MMAH_RS02140	COG2205	protein histidine kinase activity
MMAH_RS02155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MMAH_RS02155	COG0235	Class ii aldolase
MMAH_RS02185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MMAH_RS02190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MMAH_RS02200	COG1592	Rubrerythrin
MMAH_RS02210	COG1321	iron dependent repressor
MMAH_RS02215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MMAH_RS02225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MMAH_RS02245	COG0556	nucleotide-excision repair
MMAH_RS02330	COG0517	IMP dehydrogenase activity
MMAH_RS02330	COG0516	GMP reductase activity
MMAH_RS02340	COG0693	protein deglycase activity
MMAH_RS02360	COG0281	malic enzyme
MMAH_RS02365	COG1047	Peptidyl-prolyl cis-trans
MMAH_RS02370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MMAH_RS02400	COG1509	lysine 2,3-aminomutase activity
MMAH_RS02435	COG0539	negative regulation of cytoplasmic translation
MMAH_RS02460	COG0745	RESPONSE REGULATOR receiver
MMAH_RS02475	COG5012	cobalamin binding
MMAH_RS02500	COG0826	peptidase U32
MMAH_RS02525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MMAH_RS02535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MMAH_RS02555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MMAH_RS02565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MMAH_RS02590	COG1418	mRNA catabolic process
MMAH_RS02595	COG0402	S-adenosylhomocysteine deaminase activity
MMAH_RS02605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MMAH_RS02620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MMAH_RS02625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MMAH_RS02640	COG0085	RNA polymerase activity
MMAH_RS02645	COG0085	RNA polymerase activity
MMAH_RS02650	COG0433	COG0433 Predicted ATPase
MMAH_RS02650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MMAH_RS02655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MMAH_RS02675	COG0049	tRNA binding
MMAH_RS02680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MMAH_RS02685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MMAH_RS02735	COG0674	pyruvate-flavodoxin oxidoreductase activity
MMAH_RS02735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MMAH_RS02740	COG1013	pyruvate-flavodoxin oxidoreductase activity
MMAH_RS02745	COG1331	Highly conserved protein containing a thioredoxin domain
MMAH_RS02750	COG1331	Highly conserved protein containing a thioredoxin domain
MMAH_RS02790	COG2033	superoxide reductase activity
MMAH_RS02800	COG0450	alkyl hydroperoxide reductase
MMAH_RS02810	COG0535	radical SAM domain protein
MMAH_RS02820	COG1648	precorrin-2 dehydrogenase activity
MMAH_RS02820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MMAH_RS02845	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MMAH_RS02860	COG1793	dna ligase
MMAH_RS02865	COG0460	homoserine dehydrogenase
MMAH_RS02905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MMAH_RS02910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MMAH_RS02915	COG0644	oxidoreductase
MMAH_RS02925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MMAH_RS02930	COG0473	3-isopropylmalate dehydrogenase activity
MMAH_RS02960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MMAH_RS02975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MMAH_RS02985	COG2205	protein histidine kinase activity
MMAH_RS02990	COG1120	ATPase activity
MMAH_RS02995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MMAH_RS03005	COG0247	lactate metabolic process
MMAH_RS03005	COG2181	nitrate reductase activity
MMAH_RS03035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MMAH_RS03040	COG0151	Belongs to the GarS family
MMAH_RS03045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MMAH_RS03060	COG1138	Cytochrome C-type biogenesis protein
MMAH_RS03070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MMAH_RS03075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MMAH_RS03115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MMAH_RS03125	COG0511	ligase activity, forming carbon-carbon bonds
MMAH_RS03125	COG5016	pyruvate
MMAH_RS03130	COG0439	Biotin carboxylase
MMAH_RS03135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MMAH_RS03135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MMAH_RS03165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MMAH_RS03175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MMAH_RS03185	COG2181	nitrate reductase activity
MMAH_RS03185	COG0247	lactate metabolic process
MMAH_RS03205	COG0589	response to stress
MMAH_RS03210	COG4555	ABC transporter
MMAH_RS03215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MMAH_RS03220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MMAH_RS03230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MMAH_RS03270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MMAH_RS03270	COG0574	Belongs to the PEP-utilizing enzyme family
MMAH_RS03310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MMAH_RS03325	COG1598	PFAM Uncharacterised protein family UPF0150
MMAH_RS03355	COG0668	transmembrane transport
MMAH_RS03365	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MMAH_RS03370	COG1185	polyribonucleotide nucleotidyltransferase activity
MMAH_RS03410	COG0343	queuine tRNA-ribosyltransferase activity
MMAH_RS03415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MMAH_RS03460	COG1515	deoxyribonuclease V activity
MMAH_RS03485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MMAH_RS03490	COG0423	glycine-tRNA ligase activity
MMAH_RS03495	COG1830	Aldolase
MMAH_RS03540	COG0306	phosphate transporter
MMAH_RS03555	COG2046	Belongs to the sulfate adenylyltransferase family
MMAH_RS03565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MMAH_RS03575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MMAH_RS03600	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MMAH_RS03620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MMAH_RS03635	COG2003	Belongs to the UPF0758 family
MMAH_RS03640	COG0314	molybdopterin synthase activity
MMAH_RS03645	COG3875	lactate racemase activity
MMAH_RS03655	COG0114	fumarate hydratase activity
MMAH_RS03660	COG1053	succinate dehydrogenase
MMAH_RS03665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MMAH_RS03715	COG0009	L-threonylcarbamoyladenylate synthase
MMAH_RS03720	COG1320	monovalent cation:proton antiporter activity
MMAH_RS03725	COG2212	antiporter activity
MMAH_RS03730	COG1863	multisubunit Na H antiporter MnhE subunit
MMAH_RS03735	COG0651	ATP synthesis coupled electron transport
MMAH_RS03745	COG2111	Na H antiporter
MMAH_RS03750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MMAH_RS03750	COG2111	Na H antiporter
MMAH_RS03775	COG1111	helicase
MMAH_RS03775	COG1205	dead DEAH box helicase
MMAH_RS03790	COG2326	polyphosphate kinase activity
MMAH_RS03795	COG0248	Ppx GppA phosphatase
MMAH_RS03800	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MMAH_RS03815	COG0704	Plays a role in the regulation of phosphate uptake
MMAH_RS03820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MMAH_RS03825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MMAH_RS03830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MMAH_RS03845	COG1739	Uncharacterized protein family UPF0029
MMAH_RS03850	COG0534	Mate efflux family protein
MMAH_RS03855	COG0667	Aldo Keto reductase
MMAH_RS03890	COG0297	glycogen (starch) synthase activity
MMAH_RS03915	COG1011	Hydrolase
MMAH_RS03950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MMAH_RS03990	COG0442	prolyl-tRNA aminoacylation
MMAH_RS03995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MMAH_RS04035	COG1185	polyribonucleotide nucleotidyltransferase activity
MMAH_RS04040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MMAH_RS04060	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MMAH_RS04065	COG1691	(AIR) carboxylase
MMAH_RS04070	COG4451	ribulose bisphosphate carboxylase, small
MMAH_RS04070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MMAH_RS04080	COG0622	Phosphoesterase
MMAH_RS04090	COG0826	peptidase U32
MMAH_RS04095	COG3063	Type IV pilus biogenesis stability protein PilW
MMAH_RS04100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MMAH_RS04145	COG5002	protein histidine kinase activity
MMAH_RS04170	COG0577	efflux transmembrane transporter activity
MMAH_RS04180	COG1136	(ABC) transporter
MMAH_RS04185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MMAH_RS04195	COG2205	protein histidine kinase activity
MMAH_RS04205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MMAH_RS04215	COG0778	Nitroreductase
MMAH_RS04220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MMAH_RS04225	COG0440	acetolactate synthase activity
MMAH_RS04230	COG0028	Belongs to the TPP enzyme family
MMAH_RS04235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MMAH_RS04240	COG1363	Peptidase, m42
MMAH_RS04245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MMAH_RS04260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MMAH_RS04285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MMAH_RS04290	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MMAH_RS04295	COG0017	Asparaginyl-tRNA synthetase
MMAH_RS04300	COG0187	DNA topoisomerase II activity
MMAH_RS04305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MMAH_RS04310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MMAH_RS04315	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MMAH_RS04345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MMAH_RS04350	COG0105	UTP biosynthetic process
MMAH_RS04405	COG0590	tRNA wobble adenosine to inosine editing
MMAH_RS04425	COG0704	Plays a role in the regulation of phosphate uptake
MMAH_RS04430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MMAH_RS04435	COG0581	inorganic phosphate transmembrane transporter activity
MMAH_RS04440	COG0573	inorganic phosphate transmembrane transporter activity
MMAH_RS04445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MMAH_RS04450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MMAH_RS04455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MMAH_RS04460	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MMAH_RS04495	COG3063	Type IV pilus biogenesis stability protein PilW
MMAH_RS04515	COG0822	iron-sulfur transferase activity
MMAH_RS04520	COG1104	cysteine desulfurase activity
MMAH_RS04525	COG2210	Belongs to the sulfur carrier protein TusA family
MMAH_RS04530	COG0425	Belongs to the sulfur carrier protein TusA family
MMAH_RS04540	COG0523	cobalamin synthesis protein
MMAH_RS04550	COG0531	amino acid
MMAH_RS04570	COG2814	Major facilitator Superfamily
MMAH_RS04575	COG5002	protein histidine kinase activity
MMAH_RS04635	COG1139	Iron-sulfur cluster binding protein
MMAH_RS04640	COG0469	pyruvate kinase activity
MMAH_RS04655	COG3769	mannosylglycerate metabolic process
MMAH_RS04675	COG1201	RNA secondary structure unwinding
MMAH_RS04700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MMAH_RS04705	COG0028	Belongs to the TPP enzyme family
MMAH_RS04720	COG0352	thiamine-phosphate diphosphorylase activity
MMAH_RS04730	COG0037	tRNA processing
MMAH_RS04765	COG2814	Major facilitator Superfamily
MMAH_RS04775	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MMAH_RS04820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MMAH_RS04830	COG0505	Belongs to the CarA family
MMAH_RS04835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MMAH_RS04840	COG0137	argininosuccinate synthase activity
MMAH_RS04845	COG2076	Multidrug Resistance protein
MMAH_RS04865	COG0714	Associated with various cellular activities
MMAH_RS04875	COG1605	Chorismate mutase
MMAH_RS04875	COG0077	Prephenate dehydratase
MMAH_RS04905	COG5012	cobalamin binding
MMAH_RS04915	COG5012	cobalamin binding
MMAH_RS04925	COG1584	GPR1 FUN34 yaaH family protein
MMAH_RS04955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MMAH_RS04960	COG2848	UPF0210 protein
MMAH_RS04965	COG3830	Belongs to the UPF0237 family
MMAH_RS04980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MMAH_RS05020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MMAH_RS05020	COG0574	Belongs to the PEP-utilizing enzyme family
MMAH_RS05035	COG0396	ATPase activity
MMAH_RS05040	COG0719	Fe-S assembly protein
MMAH_RS05045	COG0655	NAD(P)H dehydrogenase (quinone) activity
MMAH_RS05085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MMAH_RS05085	COG0674	pyruvate-flavodoxin oxidoreductase activity
MMAH_RS05105	COG1404	Belongs to the peptidase S8 family
MMAH_RS05110	COG3447	MASE1 domain protein
MMAH_RS05110	COG5001	Diguanylate cyclase
MMAH_RS05110	COG5002	protein histidine kinase activity
MMAH_RS05115	COG0312	modulator of DNA gyrase
MMAH_RS05120	COG0312	modulator of DNA gyrase
MMAH_RS05125	COG1067	ATP-dependent peptidase activity
MMAH_RS05125	COG0470	DNA polymerase III
MMAH_RS05130	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MMAH_RS05140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MMAH_RS05145	COG0077	Prephenate dehydratase
MMAH_RS05145	COG1605	Chorismate mutase
MMAH_RS05160	COG0145	ligase activity
MMAH_RS05165	COG2890	protein-(glutamine-N5) methyltransferase activity
MMAH_RS05170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MMAH_RS05260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MMAH_RS05275	COG0497	DNA recombination
MMAH_RS05290	COG0798	PFAM Bile acid sodium symporter
MMAH_RS05295	COG3431	PFAM Phosphate-starvation-inducible E
MMAH_RS05300	COG0450	alkyl hydroperoxide reductase
MMAH_RS05335	COG5002	protein histidine kinase activity
MMAH_RS05380	COG0425	Belongs to the sulfur carrier protein TusA family
MMAH_RS05380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MMAH_RS05390	COG0215	cysteine-tRNA ligase activity
MMAH_RS05395	COG0430	RNA-3'-phosphate cyclase activity
MMAH_RS05400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MMAH_RS05410	COG0574	Belongs to the PEP-utilizing enzyme family
MMAH_RS05410	COG3848	Pyruvate phosphate dikinase
MMAH_RS05410	COG3848	Pyruvate phosphate dikinase
MMAH_RS05410	COG0574	Belongs to the PEP-utilizing enzyme family
MMAH_RS05455	COG0589	response to stress
MMAH_RS05465	COG1796	DNA polymerase
MMAH_RS05465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MMAH_RS05470	COG1793	dna ligase
MMAH_RS05495	COG0189	ligase activity
MMAH_RS05500	COG0189	ligase activity
MMAH_RS05500	COG4067	protein conserved in archaea
MMAH_RS05510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MMAH_RS05535	COG0039	L-malate dehydrogenase activity
MMAH_RS05540	COG2610	gluconate transmembrane transporter activity
MMAH_RS05545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MMAH_RS05590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MMAH_RS05600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MMAH_RS05600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MMAH_RS05605	COG0436	Aminotransferase
MMAH_RS05610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MMAH_RS05620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MMAH_RS05630	COG0530	calcium, potassium:sodium antiporter activity
MMAH_RS05665	COG0531	amino acid
MMAH_RS05680	COG5012	cobalamin binding
MMAH_RS05685	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MMAH_RS05695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MMAH_RS05715	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MMAH_RS05735	COG0318	PFAM AMP-dependent synthetase and ligase
MMAH_RS05745	COG0745	RESPONSE REGULATOR receiver
MMAH_RS05775	COG5012	cobalamin binding
MMAH_RS05795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MMAH_RS05800	COG0483	inositol monophosphate 1-phosphatase activity
MMAH_RS05805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MMAH_RS05810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MMAH_RS05865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MMAH_RS05925	COG0390	transport system, permease component
MMAH_RS05930	COG1126	abc transporter atp-binding protein
MMAH_RS05935	COG1489	DNA binding
MMAH_RS05960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MMAH_RS05970	COG0746	molybdenum cofactor guanylyltransferase activity
MMAH_RS05995	COG0492	ferredoxin-NADP+ reductase activity
MMAH_RS06005	COG0134	indole-3-glycerol-phosphate synthase activity
MMAH_RS06010	COG0133	tryptophan synthase activity
MMAH_RS06015	COG0159	tryptophan synthase activity
MMAH_RS06020	COG0552	protein localization to endoplasmic reticulum
MMAH_RS06065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MMAH_RS06080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MMAH_RS06085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MMAH_RS06090	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MMAH_RS06110	COG0514	ATP-dependent DNA helicase (RecQ)
MMAH_RS06115	COG0519	Catalyzes the synthesis of GMP from XMP
MMAH_RS06115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MMAH_RS06125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MMAH_RS06150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MMAH_RS06180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MMAH_RS06210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MMAH_RS06220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MMAH_RS06235	COG1047	Peptidyl-prolyl cis-trans
MMAH_RS06245	COG5002	protein histidine kinase activity
MMAH_RS06250	COG0516	GMP reductase activity
MMAH_RS06250	COG0517	IMP dehydrogenase activity
MMAH_RS06265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MMAH_RS06280	COG0644	oxidoreductase
MMAH_RS06295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MMAH_RS06310	COG1615	UPF0182 protein
MMAH_RS06325	COG1229	Formylmethanofuran dehydrogenase subunit A
MMAH_RS06340	COG3383	formate dehydrogenase (NAD+) activity
MMAH_RS06360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MMAH_RS06375	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MMAH_RS06385	COG0798	PFAM Bile acid sodium symporter
MMAH_RS06430	COG1695	Transcriptional regulator
MMAH_RS06455	COG2226	methyltransferase
MMAH_RS06460	COG0450	alkyl hydroperoxide reductase
MMAH_RS06490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MMAH_RS06495	COG0531	amino acid
MMAH_RS06580	COG0569	domain protein
MMAH_RS06610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MMAH_RS06625	COG1213	nucleotidyl transferase
MMAH_RS06625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MMAH_RS06645	COG0436	Aminotransferase
MMAH_RS06655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MMAH_RS06665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MMAH_RS06670	COG1102	Psort location Cytoplasmic, score
MMAH_RS06680	COG0563	adenylate kinase activity
MMAH_RS06690	COG0200	Binds to the 23S rRNA
MMAH_RS06700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MMAH_RS06735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MMAH_RS06750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MMAH_RS06755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MMAH_RS06765	COG0255	Belongs to the universal ribosomal protein uL29 family
MMAH_RS06770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MMAH_RS06780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MMAH_RS06785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MMAH_RS06790	COG0089	rRNA binding
MMAH_RS06800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MMAH_RS06840	COG0284	orotidine-5'-phosphate decarboxylase activity
MMAH_RS06845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MMAH_RS06850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MMAH_RS06850	COG0731	radical SAM domain protein
MMAH_RS06860	COG1342	Belongs to the UPF0251 family
MMAH_RS06870	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MMAH_RS06885	COG0037	tRNA processing
MMAH_RS06905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MMAH_RS06910	COG0436	Aminotransferase
MMAH_RS06915	COG3527	Alpha-acetolactate decarboxylase
MMAH_RS06925	COG1121	(ABC) transporter
MMAH_RS06930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MMAH_RS06935	COG5002	protein histidine kinase activity
MMAH_RS06940	COG5002	protein histidine kinase activity
MMAH_RS06950	COG0252	asparaginase activity
MMAH_RS06955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MMAH_RS07000	COG0371	Dehydrogenase
MMAH_RS07030	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MMAH_RS07035	COG1797	cobyrinic acid a,c-diamide synthase activity
MMAH_RS07055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MMAH_RS07070	COG1151	hydroxylamine reductase activity
MMAH_RS07080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MMAH_RS07085	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MMAH_RS07090	COG1733	regulation of RNA biosynthetic process
MMAH_RS07095	COG1151	hydroxylamine reductase activity
MMAH_RS07160	COG1394	ATPase activity, coupled to movement of substances
MMAH_RS07165	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MMAH_RS07170	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MMAH_RS07195	COG1269	ATP hydrolysis coupled proton transport
MMAH_RS07205	COG0535	radical SAM domain protein
MMAH_RS07210	COG0142	geranyltranstransferase activity
MMAH_RS07220	COG0535	radical SAM domain protein
MMAH_RS07225	COG1522	sequence-specific DNA binding
MMAH_RS07230	COG1522	sequence-specific DNA binding
MMAH_RS07240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MMAH_RS07245	COG0113	porphobilinogen synthase activity
MMAH_RS07255	COG0181	hydroxymethylbilane synthase activity
MMAH_RS07260	COG0167	dihydroorotate dehydrogenase activity
MMAH_RS07275	COG0179	Fumarylacetoacetate (FAA) hydrolase
MMAH_RS07285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MMAH_RS07300	COG1573	uracil-dna glycosylase
MMAH_RS07325	COG0500	methyltransferase
MMAH_RS07355	COG5012	cobalamin binding
MMAH_RS07385	COG0402	S-adenosylhomocysteine deaminase activity
MMAH_RS07390	COG0589	response to stress
MMAH_RS07395	COG0517	IMP dehydrogenase activity
MMAH_RS07395	COG0516	GMP reductase activity
MMAH_RS07400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MMAH_RS07400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MMAH_RS07410	COG0785	Cytochrome C biogenesis protein
MMAH_RS07445	COG2264	protein methyltransferase activity
MMAH_RS07450	COG1492	cobalamin metabolic process
MMAH_RS07460	COG0745	RESPONSE REGULATOR receiver
MMAH_RS07470	COG2202	Pas domain
MMAH_RS07470	COG2205	protein histidine kinase activity
MMAH_RS07475	COG0598	Magnesium transport protein CorA
MMAH_RS07480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MMAH_RS07485	COG0135	phosphoribosylanthranilate isomerase activity
MMAH_RS07515	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MMAH_RS07560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MMAH_RS07560	COG1017	nitric oxide dioxygenase activity
MMAH_RS07565	COG0163	prenyltransferase activity
MMAH_RS07575	COG1260	myo-inositol-1-phosphate synthase
MMAH_RS07640	COG0426	domain, Protein
MMAH_RS07650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MMAH_RS07675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MMAH_RS07695	COG0052	Belongs to the universal ribosomal protein uS2 family
MMAH_RS07700	COG1355	regulation of microtubule-based process
MMAH_RS07715	COG1304	FMN binding
MMAH_RS07730	COG4962	Type ii secretion system protein e
MMAH_RS07760	COG2202	Pas domain
MMAH_RS07760	COG2205	protein histidine kinase activity
MMAH_RS07765	COG3431	PFAM Phosphate-starvation-inducible E
MMAH_RS07815	COG0535	radical SAM domain protein
MMAH_RS07815	COG1433	Dinitrogenase iron-molybdenum cofactor
MMAH_RS07825	COG0602	queuosine metabolic process
MMAH_RS07835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MMAH_RS07855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MMAH_RS07875	COG0189	ligase activity
MMAH_RS07890	COG0585	pseudouridine synthase activity
MMAH_RS07895	COG0504	CTP synthase activity
MMAH_RS07920	COG1007	ATP synthesis coupled electron transport
MMAH_RS07925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMAH_RS07945	COG0839	Belongs to the complex I subunit 6 family
MMAH_RS07950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMAH_RS07955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MMAH_RS07970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMAH_RS07975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMAH_RS08005	COG0424	maF-like protein
MMAH_RS08010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MMAH_RS08015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MMAH_RS08020	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MMAH_RS08030	COG1324	tolerance protein
MMAH_RS08035	COG0644	oxidoreductase
MMAH_RS08040	COG0569	domain protein
MMAH_RS08045	COG0484	heat shock protein binding
MMAH_RS08055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MMAH_RS08095	COG0301	tRNA thio-modification
MMAH_RS08115	COG1254	Belongs to the acylphosphatase family
MMAH_RS08120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MMAH_RS08130	COG0175	sulfate reduction
MMAH_RS08135	COG0493	'glutamate synthase
MMAH_RS08160	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MMAH_RS08165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MMAH_RS08170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MMAH_RS08195	COG0640	Transcriptional regulator
MMAH_RS08215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MMAH_RS08225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MMAH_RS08235	COG2078	PFAM AMMECR1 domain protein
MMAH_RS08240	COG0126	phosphoglycerate kinase activity
MMAH_RS08245	COG0857	belongs to the CobB CobQ family
MMAH_RS08250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MMAH_RS08250	COG1042	CoA-binding domain protein
MMAH_RS08250	COG0045	succinate-CoA ligase (ADP-forming) activity
MMAH_RS08260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MMAH_RS08265	COG1494	fructose-1,6-bisphosphatase
MMAH_RS08275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MMAH_RS08280	COG0495	leucyl-tRNA aminoacylation
MMAH_RS08285	COG1122	ATPase activity
MMAH_RS08290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MMAH_RS08300	COG0310	cobalt ion transport
MMAH_RS08360	COG5012	cobalamin binding
MMAH_RS08375	COG5012	cobalamin binding
MMAH_RS08415	COG2255	four-way junction helicase activity
MMAH_RS08425	COG2878	Part of a membrane complex involved in electron transport
MMAH_RS08425	COG1245	4Fe-4S binding domain
MMAH_RS08430	COG4657	Part of a membrane complex involved in electron transport
MMAH_RS08435	COG4660	Part of a membrane complex involved in electron transport
MMAH_RS08440	COG4659	FMN binding
MMAH_RS08445	COG4658	electron transport chain
MMAH_RS08450	COG4656	Part of a membrane complex involved in electron transport
MMAH_RS08460	COG1477	protein flavinylation
MMAH_RS08465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MMAH_RS08505	COG1185	polyribonucleotide nucleotidyltransferase activity
MMAH_RS08540	COG0577	efflux transmembrane transporter activity
MMAH_RS08545	COG1136	(ABC) transporter
MMAH_RS08545	COG0577	efflux transmembrane transporter activity
MMAH_RS08555	COG1136	(ABC) transporter
MMAH_RS08565	COG4591	ABC-type transport system involved in lipoprotein release permease component
MMAH_RS08570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MMAH_RS08575	COG1078	dGTPase activity
MMAH_RS08585	COG0163	prenyltransferase activity
MMAH_RS08595	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MMAH_RS08605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MMAH_RS08610	COG1993	acr, cog1993
MMAH_RS08625	COG0521	Mo-molybdopterin cofactor biosynthetic process
MMAH_RS08635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MMAH_RS08655	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MMAH_RS08670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MMAH_RS08680	COG2264	protein methyltransferase activity
MMAH_RS08685	COG1185	polyribonucleotide nucleotidyltransferase activity
MMAH_RS08695	COG1982	Orn Lys Arg decarboxylase major
MMAH_RS08705	COG2897	thiosulfate sulfurtransferase activity
MMAH_RS08715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MMAH_RS08720	COG2166	iron-sulfur cluster assembly
MMAH_RS08750	COG0028	Belongs to the TPP enzyme family
MMAH_RS08750	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MMAH_RS08805	COG0322	excinuclease ABC activity
MMAH_RS08810	COG0589	response to stress
MMAH_RS08890	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MMAH_RS08895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MMAH_RS08905	COG2048	Heterodisulfide reductase, subunit B
MMAH_RS08910	COG0247	lactate metabolic process
MMAH_RS08910	COG2181	nitrate reductase activity
MMAH_RS08920	COG0067	glutamate synthase
MMAH_RS08940	COG1570	exodeoxyribonuclease VII activity
MMAH_RS08945	COG1722	exodeoxyribonuclease VII activity
MMAH_RS08950	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MMAH_RS08985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MMAH_RS09020	COG0420	3'-5' exonuclease activity
MMAH_RS09025	COG1196	nuclear chromosome segregation
MMAH_RS09035	COG1196	nuclear chromosome segregation
MMAH_RS09040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MMAH_RS09045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MMAH_RS09060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MMAH_RS09065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MMAH_RS09100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MMAH_RS09100	COG1918	ferrous iron import across plasma membrane
MMAH_RS09120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MMAH_RS09130	COG0640	Transcriptional regulator
MMAH_RS09160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MMAH_RS09165	COG3842	ATPase activity
MMAH_RS09170	COG4149	molybdate abc transporter
MMAH_RS09175	COG0725	ABC transporter, periplasmic molybdate-binding protein
MMAH_RS09205	COG0784	Response regulator, receiver
MMAH_RS09210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MMAH_RS09215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MMAH_RS09270	COG1122	ATPase activity
MMAH_RS09275	COG2217	Heavy metal translocating P-type atpase
MMAH_RS09280	COG1525	nuclease
MMAH_RS09290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MMAH_RS09295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MMAH_RS09310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MMAH_RS09320	COG1160	GTP binding
MMAH_RS09335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MMAH_RS09340	COG0436	Aminotransferase
MMAH_RS09345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MMAH_RS09350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MMAH_RS09350	COG0617	tRNA 3'-terminal CCA addition
MMAH_RS09350	COG0517	IMP dehydrogenase activity
MMAH_RS09355	COG0140	phosphoribosyl-ATP diphosphatase activity
MMAH_RS09380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MMAH_RS09380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MMAH_RS09390	COG0315	cyclic pyranopterin monophosphate synthase activity
MMAH_RS09395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MMAH_RS09405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MMAH_RS09420	COG1918	ferrous iron import across plasma membrane
MMAH_RS09420	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MMAH_RS09435	COG0019	diaminopimelate decarboxylase activity
MMAH_RS09440	COG1945	arginine decarboxylase activity
MMAH_RS09455	COG3613	nucleoside 2-deoxyribosyltransferase
MMAH_RS09460	COG0826	peptidase U32
MMAH_RS09470	COG0107	imidazoleglycerol-phosphate synthase activity
MMAH_RS09495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MMAH_RS09500	COG1122	ATPase activity
MMAH_RS09505	COG1121	(ABC) transporter
MMAH_RS09520	COG3118	belongs to the thioredoxin family
MMAH_RS09550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MMAH_RS09555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MMAH_RS09560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MMAH_RS09565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MMAH_RS09595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MMAH_RS09605	COG0330	HflC and HflK could
MMAH_RS09615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MMAH_RS09620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MMAH_RS09625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MMAH_RS09645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MMAH_RS09655	COG0316	Belongs to the HesB IscA family
MMAH_RS09700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MMAH_RS09710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MMAH_RS09725	COG0500	methyltransferase
MMAH_RS09735	COG0084	hydrolase, TatD family'
MMAH_RS09760	COG0277	FAD linked oxidase domain protein
MMAH_RS09770	COG0456	acetyltransferase
MMAH_RS09785	COG0066	3-isopropylmalate dehydratase activity
MMAH_RS09790	COG0473	3-isopropylmalate dehydrogenase activity
MMAH_RS09815	COG4172	Belongs to the ABC transporter superfamily
MMAH_RS09820	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MMAH_RS09830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MMAH_RS09835	COG0154	amidase activity
MMAH_RS09850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MMAH_RS09865	COG3118	belongs to the thioredoxin family
MMAH_RS09890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MMAH_RS09895	COG1891	lyase activity
MMAH_RS09900	COG1458	PINc domain ribonuclease
MMAH_RS09905	COG0109	protoheme IX farnesyltransferase activity
MMAH_RS09910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MMAH_RS09915	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MMAH_RS09920	COG0157	Belongs to the NadC ModD family
MMAH_RS09960	COG1136	(ABC) transporter
MMAH_RS09975	COG0148	phosphopyruvate hydratase activity
MMAH_RS09980	COG4591	ABC-type transport system involved in lipoprotein release permease component
MMAH_RS09985	COG0417	DNA replication proofreading
MMAH_RS09990	COG0753	catalase activity
MMAH_RS09995	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MMAH_RS10005	COG1301	dicarboxylic acid transport
MMAH_RS10015	COG2361	Protein of unknown function DUF86
MMAH_RS10060	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MMAH_RS10065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MMAH_RS10070	COG0475	glutathione-regulated potassium exporter activity
MMAH_RS10080	COG1122	ATPase activity
MMAH_RS10090	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MMAH_RS10095	COG0310	cobalt ion transport
MMAH_RS10105	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MMAH_RS10110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MMAH_RS10115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MMAH_RS10140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MMAH_RS10140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MMAH_RS10150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MMAH_RS10155	COG2217	Heavy metal translocating P-type atpase
MMAH_RS10160	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MMAH_RS10165	COG3402	PFAM membrane-flanked domain
MMAH_RS10185	COG0076	glutamate decarboxylase activity
MMAH_RS10215	COG2202	Pas domain
MMAH_RS10215	COG2205	protein histidine kinase activity
MMAH_RS10240	COG2205	protein histidine kinase activity
MMAH_RS10325	COG0367	asparagine synthase