locus-tag	class	description
MK0001	COG0430	RNA-3'-phosphate cyclase activity
MK0003	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MK0005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MK0006	COG2255	four-way junction helicase activity
MK0021	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MK0022	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MK0029	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MK0036	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MK0039	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MK0043	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK0043	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK0044	COG1242	4 iron, 4 sulfur cluster binding
MK0045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MK0049	COG1110	DNA topoisomerase II activity
MK0051	COG0037	tRNA processing
MK0054	COG0347	Belongs to the P(II) protein family
MK0057	COG1628	Protein of unknown function DUF99
MK0062	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MK0070	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MK0073	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MK0079	COG0077	Prephenate dehydratase
MK0079	COG1605	Chorismate mutase
MK0080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MK0081	COG1144	Oxidoreductase
MK0082	COG0674	pyruvate-flavodoxin oxidoreductase activity
MK0083	COG1013	pyruvate-flavodoxin oxidoreductase activity
MK0084	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MK0086	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MK0089	COG0517	IMP dehydrogenase activity
MK0089	COG0516	GMP reductase activity
MK0091	COG0488	(ABC) transporter
MK0094	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MK0097	COG2192	nodulation
MK0101	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MK0103	COG0367	asparagine synthase
MK0106	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MK0109	COG0460	homoserine dehydrogenase
MK0109	COG0527	aspartate kinase activity
MK0111	COG4581	dead DEAH box helicase
MK0114	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MK0116	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MK0117	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MK0122	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MK0127	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MK0129	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MK0130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MK0132	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MK0133	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MK0138	COG2045	Belongs to the ComB family
MK0141	COG0730	response to heat
MK0142	COG0589	response to stress
MK0143	COG0730	response to heat
MK0146	COG1444	tRNA N-acetyltransferase activity
MK0152	COG0423	glycine-tRNA ligase activity
MK0154	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MK0156	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MK0157	COG1185	polyribonucleotide nucleotidyltransferase activity
MK0161	COG1183	phosphatidylcholine synthase activity
MK0162	COG0688	phosphatidylethanolamine metabolic process
MK0163	COG2226	methyltransferase
MK0164	COG0481	GTPase activity
MK0171	COG0501	Belongs to the peptidase M48B family
MK0173	COG0107	imidazoleglycerol-phosphate synthase activity
MK0178	COG3259	Nickel-dependent hydrogenase
MK0182	COG1122	ATPase activity
MK0187	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MK0188	COG0343	queuine tRNA-ribosyltransferase activity
MK0189	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MK0192	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MK0193	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MK0194	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MK0198	COG0113	porphobilinogen synthase activity
MK0203	COG0561	phosphatase activity
MK0205	COG0504	CTP synthase activity
MK0207	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MK0218	COG2894	cell division
MK0219	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MK0223	COG0006	proline dipeptidase activity
MK0224	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MK0226	COG0409	Hydrogenase expression formation protein
MK0227	COG0298	carbon dioxide binding
MK0234	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MK0235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MK0238	COG0154	amidase activity
MK0239	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MK0240	COG0489	protein tyrosine kinase activity
MK0247	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MK0248	COG0673	inositol 2-dehydrogenase activity
MK0252	COG0574	Belongs to the PEP-utilizing enzyme family
MK0252	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MK0257	COG0425	Belongs to the sulfur carrier protein TusA family
MK0258	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
MK0259	COG0243	molybdopterin cofactor binding
MK0266	COG3259	Nickel-dependent hydrogenase
MK0267	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
MK0275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MK0280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MK0281	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MK0282	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MK0289	COG1110	DNA topoisomerase II activity
MK0291	COG0717	Belongs to the dCTP deaminase family
MK0295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK0295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK0297	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MK0320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MK0333	COG0083	homoserine kinase activity
MK0335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MK0343	COG0180	Tryptophanyl-tRNA synthetase
MK0363	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MK0363	COG0519	Catalyzes the synthesis of GMP from XMP
MK0364	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MK0365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MK0366	COG0402	S-adenosylhomocysteine deaminase activity
MK0368	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MK0370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MK0370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK0372	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MK0373	COG0012	GTP binding
MK0380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MK0383	COG1363	Peptidase, m42
MK0385	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MK0391	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MK0392	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MK0394	COG1809	phosphosulfolactate synthase activity
MK0398	COG1187	pseudouridine synthase activity
MK0403	COG0159	tryptophan synthase activity
MK0404	COG0530	calcium, potassium:sodium antiporter activity
MK0408	COG1714	RDD family
MK0412	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MK0413	COG0089	rRNA binding
MK0415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MK0419	COG1185	polyribonucleotide nucleotidyltransferase activity
MK0426	COG0418	dihydroorotase activity
MK0429	COG0710	3-dehydroquinate dehydratase activity
MK0430	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MK0433	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MK0434	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MK0435	COG2171	N-acyltransferase activity
MK0436	COG0512	Glutamine amidotransferase of anthranilate synthase
MK0436	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MK0437	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MK0444	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK0444	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK0446	COG0157	Belongs to the NadC ModD family
MK0451	COG1077	Cell shape determining protein MreB Mrl
MK0456	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MK0463	COG0649	NAD binding
MK0464	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MK0478	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MK0482	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MK0483	COG0019	diaminopimelate decarboxylase activity
MK0485	COG1469	GTP cyclohydrolase I activity
MK0488	COG2078	PFAM AMMECR1 domain protein
MK0489	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MK0494	COG1418	mRNA catabolic process
MK0497	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MK0499	COG1530	ribonuclease E activity
MK0500	COG0140	phosphoribosyl-ATP diphosphatase activity
MK0501	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MK0504	COG1335	isochorismatase
MK0505	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
MK0508	COG0135	phosphoribosylanthranilate isomerase activity
MK0509	COG1429	ligase activity, forming nitrogen-metal bonds
MK0513	COG1185	polyribonucleotide nucleotidyltransferase activity
MK0516	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MK0519	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MK0526	COG0617	tRNA 3'-terminal CCA addition
MK0526	COG0517	IMP dehydrogenase activity
MK0526	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MK0531	COG0028	Belongs to the TPP enzyme family
MK0533	COG0084	hydrolase, TatD family'
MK0537	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MK0538	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MK0539	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MK0544	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MK0545	COG0440	acetolactate synthase activity
MK0546	COG0084	hydrolase, TatD family'
MK0549	COG0456	acetyltransferase
MK0550	COG0069	glutamate synthase activity
MK0551	COG0519	Catalyzes the synthesis of GMP from XMP
MK0552	COG0475	glutathione-regulated potassium exporter activity
MK0554	COG0315	cyclic pyranopterin monophosphate synthase activity
MK0561	COG0306	phosphate transporter
MK0563	COG0167	dihydroorotate dehydrogenase activity
MK0564	COG0543	2 iron, 2 sulfur cluster binding
MK0566	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MK0578	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MK0578	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MK0601	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MK0602	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MK0606	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MK0607	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MK0610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MK0617	COG0358	DNA primase activity
MK0621	COG0175	sulfate reduction
MK0622	COG0165	Argininosuccinate lyase
MK0625	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MK0628	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MK0631	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MK0633	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MK0635	COG0009	L-threonylcarbamoyladenylate synthase
MK0642	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MK0648	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MK0662	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MK0667	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MK0673	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MK0673	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK0676	COG0585	pseudouridine synthase activity
MK0678	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MK0679	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MK0680	COG0049	tRNA binding
MK0684	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MK0686	COG0085	RNA polymerase activity
MK0687	COG0085	RNA polymerase activity
MK0690	COG0419	ATPase involved in DNA repair
MK0690	COG0419	ATPase involved in DNA repair
MK0709	COG2813	Specifically methylates the guanine in position
MK0710	COG0017	Asparaginyl-tRNA synthetase
MK0711	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MK0721	COG2894	cell division
MK0724	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MK0725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MK0725	COG0493	'glutamate synthase
MK0728	COG0674	pyruvate-flavodoxin oxidoreductase activity
MK0728	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MK0729	COG1013	pyruvate-flavodoxin oxidoreductase activity
MK0732	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MK0737	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MK0738	COG0010	Belongs to the arginase family
MK0739	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MK0741	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MK0742	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MK0746	COG0181	hydroxymethylbilane synthase activity
MK0752	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MK0753	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MK0755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MK0757	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MK0758	COG0018	arginyl-trna synthetase
MK0760	COG0528	UMP kinase activity
MK0766	COG1702	phosphate starvation-inducible protein PhoH
MK0767	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MK0769	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK0769	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK0772	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MK0775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MK0776	COG1304	FMN binding
MK0777	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MK0778	COG0301	tRNA thio-modification
MK0781	COG0066	3-isopropylmalate dehydratase activity
MK0782	COG0473	3-isopropylmalate dehydrogenase activity
MK0784	COG0133	tryptophan synthase activity
MK0790	COG0047	phosphoribosylformylglycinamidine synthase activity
MK0791	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MK0792	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MK0795	COG2144	transferase activity, transferring acyl groups
MK0797	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MK0798	COG0287	Prephenate dehydrogenase
MK0799	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MK0804	COG0622	Phosphoesterase
MK0807	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
MK0808	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MK0808	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MK0816	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MK0818	COG0602	queuosine metabolic process
MK0819	COG0720	synthase
MK0821	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MK0824	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MK0825	COG0081	regulation of translation
MK0826	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MK0827	COG1618	nucleotide phosphatase activity, acting on free nucleotides
MK0828	COG1053	succinate dehydrogenase
MK0829	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MK0832	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MK0835	COG0513	Belongs to the DEAD box helicase family
MK0842	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MK0847	COG0330	HflC and HflK could
MK0850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK0850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK0855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MK0855	COG0131	Imidazoleglycerol-phosphate dehydratase
MK0865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MK0869	COG0517	IMP dehydrogenase activity
MK0869	COG0516	GMP reductase activity
MK0878	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MK0880	COG0463	Glycosyl transferase, family 2
MK0881	COG0446	pyridine nucleotide-disulphide oxidoreductase
MK0888	COG0101	tRNA pseudouridine synthase activity
MK0893	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MK0896	COG0535	radical SAM domain protein
MK0897	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MK0898	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MK0899	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MK0900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MK0901	COG1328	CTP reductase activity
MK0901	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MK0907	COG0517	IMP dehydrogenase activity
MK0908	COG0301	tRNA thio-modification
MK0911	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MK0920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MK0932	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MK0934	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MK0942	COG0137	argininosuccinate synthase activity
MK0944	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MK0950	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MK0952	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MK0953	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MK0954	COG1980	fructose-bisphosphate aldolase activity
MK0955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MK0957	COG0312	modulator of DNA gyrase
MK0960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MK0963	COG1355	regulation of microtubule-based process
MK0970	COG1011	Hydrolase
MK0971	COG0778	Nitroreductase
MK0971	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MK0980	COG0535	radical SAM domain protein
MK0981	COG0750	zinc metalloprotease
MK0983	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MK0983	COG0072	phenylalanine-tRNA ligase activity
MK0986	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MK0989	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MK0990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MK0992	COG1032	radical SAM domain protein
MK0993	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MK0995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MK0999	COG1793	dna ligase
MK1002	COG0179	Fumarylacetoacetate (FAA) hydrolase
MK1004	COG0730	response to heat
MK1009	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MK1012	COG1269	ATP hydrolysis coupled proton transport
MK1017	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MK1022	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MK1024	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MK1032	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MK1033	COG1234	tRNA 3'-trailer cleavage
MK1035	COG1201	RNA secondary structure unwinding
MK1037	COG2242	protein methyltransferase activity
MK1037	COG2241	protein methyltransferase activity
MK1041	COG1429	ligase activity, forming nitrogen-metal bonds
MK1047	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MK1054	COG0037	tRNA processing
MK1058	COG0731	radical SAM domain protein
MK1058	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MK1061	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MK1062	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MK1063	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MK1065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MK1067	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MK1069	COG0039	L-malate dehydrogenase activity
MK1070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MK1071	COG0151	Belongs to the GarS family
MK1072	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MK1074	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MK1075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MK1077	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MK1081	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MK1085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MK1087	COG0347	Belongs to the P(II) protein family
MK1090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MK1090	COG0617	tRNA 3'-terminal CCA addition
MK1090	COG0517	IMP dehydrogenase activity
MK1100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MK1103	COG0037	tRNA processing
MK1105	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MK1108	COG1012	belongs to the aldehyde dehydrogenase family
MK1129	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MK1129	COG0519	Catalyzes the synthesis of GMP from XMP
MK1189	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MK1191	COG0671	phosphoesterase, PA-phosphatase related
MK1193	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MK1195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MK1197	COG0129	dihydroxy-acid dehydratase activity
MK1198	COG2095	MarC family integral membrane protein
MK1199	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MK1201	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MK1202	COG3259	Nickel-dependent hydrogenase
MK1206	COG0066	3-isopropylmalate dehydratase activity
MK1208	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MK1209	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MK1210	COG1993	acr, cog1993
MK1211	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MK1212	COG1968	undecaprenyl-diphosphatase activity
MK1213	COG3830	Belongs to the UPF0237 family
MK1214	COG2848	UPF0210 protein
MK1215	COG0473	3-isopropylmalate dehydrogenase activity
MK1217	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MK1218	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MK1221	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MK1223	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MK1224	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MK1226	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MK1227	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MK1228	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MK1229	COG0442	prolyl-tRNA aminoacylation
MK1231	COG1047	Peptidyl-prolyl cis-trans
MK1232	COG0719	Fe-S assembly protein
MK1236	COG0028	Belongs to the TPP enzyme family
MK1237	COG1458	PINc domain ribonuclease
MK1274	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MK1296	COG1337	RAMP superfamily
MK1306	COG0438	transferase activity, transferring glycosyl groups
MK1323	COG1234	tRNA 3'-trailer cleavage
MK1351	COG1429	ligase activity, forming nitrogen-metal bonds
MK1364	COG0495	leucyl-tRNA aminoacylation
MK1367	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MK1368	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MK1370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MK1371	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MK1379	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MK1381	COG0463	Glycosyl transferase, family 2
MK1385	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MK1386	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MK1391	COG0134	indole-3-glycerol-phosphate synthase activity
MK1405	COG1429	ligase activity, forming nitrogen-metal bonds
MK1408	COG1465	3-dehydroquinate synthase
MK1409	COG1830	Aldolase
MK1414	COG1492	cobalamin metabolic process
MK1416	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MK1418	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MK1426	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MK1429	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MK1431	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MK1433	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MK1434	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MK1435	COG1515	deoxyribonuclease V activity
MK1437	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MK1440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MK1447	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MK1449	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MK1450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MK1458	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MK1463	COG0434	BtpA family
MK1470	COG1418	mRNA catabolic process
MK1471	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MK1472	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MK1473	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MK1475	COG0200	Binds to the 23S rRNA
MK1476	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MK1477	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MK1480	COG0540	Belongs to the ATCase OTCase family
MK1481	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MK1482	COG0583	DNA-binding transcription factor activity
MK1484	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MK1488	COG0535	radical SAM domain protein
MK1489	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MK1491	COG2890	protein-(glutamine-N5) methyltransferase activity
MK1492	COG1324	tolerance protein
MK1495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MK1495	COG1648	precorrin-2 dehydrogenase activity
MK1498	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MK1500	COG0076	glutamate decarboxylase activity
MK1502	COG0864	Transcriptional regulator
MK1504	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MK1505	COG0482	sulfurtransferase activity
MK1508	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MK1509	COG0252	asparaginase activity
MK1510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MK1512	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MK1523	COG3842	ATPase activity
MK1524	COG0303	'Molybdopterin
MK1529	COG1229	Formylmethanofuran dehydrogenase subunit A
MK1537	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MK1538	COG0124	histidyl-tRNA synthetase
MK1539	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK1539	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK1540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MK1542	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MK1544	COG0309	Hydrogenase expression formation protein (HypE)
MK1547	COG0375	protein maturation
MK1548	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MK1548	COG1648	precorrin-2 dehydrogenase activity
MK1550	COG1587	Uroporphyrinogen-III synthase
MK1558	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MK1560	COG0679	Auxin Efflux Carrier
MK1564	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MK1566	COG0717	Belongs to the dCTP deaminase family
MK1570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MK1573	COG1797	cobyrinic acid a,c-diamide synthase activity
MK1575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK1575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK1576	COG0531	amino acid
MK1578	COG0052	Belongs to the universal ribosomal protein uS2 family
MK1581	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MK1585	COG0235	Class ii aldolase
MK1591	COG0105	UTP biosynthetic process
MK1593	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MK1594	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MK1595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MK1600	COG0517	IMP dehydrogenase activity
MK1600	COG0516	GMP reductase activity
MK1604	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MK1606	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MK1610	COG0083	homoserine kinase activity
MK1612	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MK1626	COG2244	polysaccharide biosynthetic process
MK1630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MK1630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MK1631	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MK1641	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MK1643	COG1797	cobyrinic acid a,c-diamide synthase activity
MK1647	COG0148	phosphopyruvate hydratase activity
MK1649	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MK1654	COG1136	(ABC) transporter
MK1655	COG0577	efflux transmembrane transporter activity
MK1658	COG0587	DNA-directed DNA polymerase activity
MK1662	COG0126	phosphoglycerate kinase activity
MK1665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MK1666	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MK1667	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MK1670	COG0746	molybdenum cofactor guanylyltransferase activity
MK1673	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MK1674	COG1394	ATPase activity, coupled to movement of substances
MK1680	COG0003	Pfam Anion-transporting ATPase
MK1687	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MK1688	COG0573	inorganic phosphate transmembrane transporter activity