locus-tag	class	description
MZHIL_RS00030	COG0018	arginyl-trna synthetase
MZHIL_RS00040	COG2379	hydroxypyruvate reductase
MZHIL_RS00050	COG0523	cobalamin synthesis protein
MZHIL_RS00070	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS00090	COG0517	IMP dehydrogenase activity
MZHIL_RS00100	COG0516	GMP reductase activity
MZHIL_RS00100	COG0517	IMP dehydrogenase activity
MZHIL_RS00105	COG0517	IMP dehydrogenase activity
MZHIL_RS00105	COG0516	GMP reductase activity
MZHIL_RS00110	COG0517	IMP dehydrogenase activity
MZHIL_RS00125	COG0430	RNA-3'-phosphate cyclase activity
MZHIL_RS00150	COG0277	FAD linked oxidase domain protein
MZHIL_RS00155	COG2181	nitrate reductase activity
MZHIL_RS00155	COG0247	lactate metabolic process
MZHIL_RS00165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MZHIL_RS00170	COG0084	hydrolase, TatD family'
MZHIL_RS00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MZHIL_RS00215	COG0316	Belongs to the HesB IscA family
MZHIL_RS00225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MZHIL_RS00230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MZHIL_RS00240	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MZHIL_RS00260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MZHIL_RS00265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MZHIL_RS00280	COG1185	polyribonucleotide nucleotidyltransferase activity
MZHIL_RS00285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MZHIL_RS00320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MZHIL_RS00325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MZHIL_RS00335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MZHIL_RS00365	COG3118	belongs to the thioredoxin family
MZHIL_RS00380	COG1121	(ABC) transporter
MZHIL_RS00390	COG0668	transmembrane transport
MZHIL_RS00395	COG0473	3-isopropylmalate dehydrogenase activity
MZHIL_RS00400	COG0066	3-isopropylmalate dehydratase activity
MZHIL_RS00415	COG2814	Major facilitator Superfamily
MZHIL_RS00420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MZHIL_RS00435	COG0101	tRNA pseudouridine synthase activity
MZHIL_RS00455	COG0024	Methionine aminopeptidase
MZHIL_RS00460	COG0006	proline dipeptidase activity
MZHIL_RS00480	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MZHIL_RS00485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MZHIL_RS00490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MZHIL_RS00495	COG0131	Imidazoleglycerol-phosphate dehydratase
MZHIL_RS00500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MZHIL_RS00535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MZHIL_RS00545	COG4451	ribulose bisphosphate carboxylase, small
MZHIL_RS00545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MZHIL_RS00570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MZHIL_RS00710	COG5002	protein histidine kinase activity
MZHIL_RS00715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS00720	COG0668	transmembrane transport
MZHIL_RS00735	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MZHIL_RS00750	COG1074	ATP-dependent DNA helicase activity
MZHIL_RS00810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MZHIL_RS00820	COG1122	ATPase activity
MZHIL_RS00825	COG1268	BioY protein
MZHIL_RS00830	COG0459	protein refolding
MZHIL_RS00850	COG0012	GTP binding
MZHIL_RS00855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MZHIL_RS00870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS00875	COG1234	tRNA 3'-trailer cleavage
MZHIL_RS00885	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MZHIL_RS00890	COG1051	belongs to the nudix hydrolase family
MZHIL_RS00890	COG1056	cytidyltransferase-related domain
MZHIL_RS00900	COG0798	PFAM Bile acid sodium symporter
MZHIL_RS00910	COG0512	Glutamine amidotransferase of anthranilate synthase
MZHIL_RS00910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MZHIL_RS00920	COG0135	phosphoribosylanthranilate isomerase activity
MZHIL_RS00925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MZHIL_RS00930	COG1492	cobalamin metabolic process
MZHIL_RS00975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MZHIL_RS00980	COG0517	IMP dehydrogenase activity
MZHIL_RS00985	COG0589	response to stress
MZHIL_RS00995	COG0589	response to stress
MZHIL_RS01005	COG0714	Associated with various cellular activities
MZHIL_RS01065	COG1229	Formylmethanofuran dehydrogenase subunit A
MZHIL_RS01070	COG3383	formate dehydrogenase (NAD+) activity
MZHIL_RS01095	COG0747	negative chemotaxis
MZHIL_RS01105	COG0601	transmembrane transport
MZHIL_RS01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MZHIL_RS01115	COG0444	Belongs to the ABC transporter superfamily
MZHIL_RS01120	COG4608	Belongs to the ABC transporter superfamily
MZHIL_RS01125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MZHIL_RS01130	COG1047	Peptidyl-prolyl cis-trans
MZHIL_RS01155	COG2217	Heavy metal translocating P-type atpase
MZHIL_RS01175	COG0417	DNA replication proofreading
MZHIL_RS01185	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS01195	COG1185	polyribonucleotide nucleotidyltransferase activity
MZHIL_RS01235	COG0343	queuine tRNA-ribosyltransferase activity
MZHIL_RS01250	COG0535	radical SAM domain protein
MZHIL_RS01260	COG0560	Phosphoserine phosphatase
MZHIL_RS01300	COG1515	deoxyribonuclease V activity
MZHIL_RS01305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MZHIL_RS01325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MZHIL_RS01330	COG0423	glycine-tRNA ligase activity
MZHIL_RS01340	COG1830	Aldolase
MZHIL_RS01370	COG0644	oxidoreductase
MZHIL_RS01375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MZHIL_RS01380	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MZHIL_RS01390	COG1605	Chorismate mutase
MZHIL_RS01390	COG0287	Prephenate dehydrogenase
MZHIL_RS01395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MZHIL_RS01400	COG0710	3-dehydroquinate dehydratase activity
MZHIL_RS01405	COG1465	3-dehydroquinate synthase
MZHIL_RS01410	COG1830	Aldolase
MZHIL_RS01415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS01420	COG0519	Catalyzes the synthesis of GMP from XMP
MZHIL_RS01420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MZHIL_RS01425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MZHIL_RS01435	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MZHIL_RS01440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MZHIL_RS01455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MZHIL_RS01460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MZHIL_RS01465	COG1116	anion transmembrane transporter activity
MZHIL_RS01485	COG0489	protein tyrosine kinase activity
MZHIL_RS01495	COG4536	flavin adenine dinucleotide binding
MZHIL_RS01500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MZHIL_RS01605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MZHIL_RS01610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MZHIL_RS01615	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MZHIL_RS01620	COG0540	Belongs to the ATCase OTCase family
MZHIL_RS01625	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MZHIL_RS01635	COG0519	Catalyzes the synthesis of GMP from XMP
MZHIL_RS01635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MZHIL_RS01655	COG1469	GTP cyclohydrolase I activity
MZHIL_RS01680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MZHIL_RS01705	COG2048	Heterodisulfide reductase, subunit B
MZHIL_RS01720	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
MZHIL_RS01730	COG0067	glutamate synthase
MZHIL_RS01765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MZHIL_RS01770	COG0784	Response regulator, receiver
MZHIL_RS01775	COG1509	lysine 2,3-aminomutase activity
MZHIL_RS01790	COG0028	Belongs to the TPP enzyme family
MZHIL_RS01800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MZHIL_RS01840	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MZHIL_RS01845	COG5012	cobalamin binding
MZHIL_RS01855	COG5002	protein histidine kinase activity
MZHIL_RS01880	COG4221	oxidoreductase activity
MZHIL_RS01900	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MZHIL_RS01905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MZHIL_RS01910	COG0154	amidase activity
MZHIL_RS01915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MZHIL_RS01930	COG3118	belongs to the thioredoxin family
MZHIL_RS01945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MZHIL_RS01955	COG0107	imidazoleglycerol-phosphate synthase activity
MZHIL_RS01960	COG1891	lyase activity
MZHIL_RS01970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS01975	COG1458	PINc domain ribonuclease
MZHIL_RS01980	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MZHIL_RS01985	COG0109	protoheme IX farnesyltransferase activity
MZHIL_RS01990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MZHIL_RS01995	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MZHIL_RS02015	COG0531	amino acid
MZHIL_RS02020	COG1615	UPF0182 protein
MZHIL_RS02045	COG1136	(ABC) transporter
MZHIL_RS02045	COG0577	efflux transmembrane transporter activity
MZHIL_RS02050	COG0148	phosphopyruvate hydratase activity
MZHIL_RS02075	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MZHIL_RS02100	COG1185	polyribonucleotide nucleotidyltransferase activity
MZHIL_RS02145	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MZHIL_RS02150	COG1477	protein flavinylation
MZHIL_RS02165	COG4656	Part of a membrane complex involved in electron transport
MZHIL_RS02170	COG4658	electron transport chain
MZHIL_RS02180	COG4660	Part of a membrane complex involved in electron transport
MZHIL_RS02185	COG4657	Part of a membrane complex involved in electron transport
MZHIL_RS02190	COG2878	Part of a membrane complex involved in electron transport
MZHIL_RS02190	COG1245	4Fe-4S binding domain
MZHIL_RS02200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MZHIL_RS02240	COG0047	phosphoribosylformylglycinamidine synthase activity
MZHIL_RS02245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MZHIL_RS02290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MZHIL_RS02330	COG2239	Acts as a magnesium transporter
MZHIL_RS02345	COG0145	ligase activity
MZHIL_RS02360	COG5012	cobalamin binding
MZHIL_RS02370	COG0613	PHP domain protein
MZHIL_RS02375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MZHIL_RS02390	COG1797	cobyrinic acid a,c-diamide synthase activity
MZHIL_RS02395	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MZHIL_RS02425	COG0371	Dehydrogenase
MZHIL_RS02455	COG0539	negative regulation of cytoplasmic translation
MZHIL_RS02485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MZHIL_RS02495	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MZHIL_RS02520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MZHIL_RS02550	COG0402	S-adenosylhomocysteine deaminase activity
MZHIL_RS02555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MZHIL_RS02575	COG0085	RNA polymerase activity
MZHIL_RS02580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MZHIL_RS02585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MZHIL_RS02610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MZHIL_RS02615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MZHIL_RS02630	COG0644	oxidoreductase
MZHIL_RS02635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MZHIL_RS02645	COG0581	inorganic phosphate transmembrane transporter activity
MZHIL_RS02650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MZHIL_RS02655	COG0704	Plays a role in the regulation of phosphate uptake
MZHIL_RS02660	COG4555	ABC transporter
MZHIL_RS02670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MZHIL_RS02675	COG1110	DNA topoisomerase II activity
MZHIL_RS02680	COG0778	Nitroreductase
MZHIL_RS02685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MZHIL_RS02690	COG0440	acetolactate synthase activity
MZHIL_RS02695	COG0028	Belongs to the TPP enzyme family
MZHIL_RS02700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MZHIL_RS02715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MZHIL_RS02760	COG0552	protein localization to endoplasmic reticulum
MZHIL_RS02765	COG0159	tryptophan synthase activity
MZHIL_RS02770	COG0133	tryptophan synthase activity
MZHIL_RS02780	COG0134	indole-3-glycerol-phosphate synthase activity
MZHIL_RS02895	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS02925	COG0835	chemotaxis
MZHIL_RS02930	COG2201	protein-glutamate methylesterase activity
MZHIL_RS02935	COG2201	protein-glutamate methylesterase activity
MZHIL_RS02940	COG2198	Histidine kinase
MZHIL_RS02940	COG0643	Histidine kinase
MZHIL_RS02950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MZHIL_RS02955	COG1776	CheC inhibitor of MCP methylation
MZHIL_RS02960	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MZHIL_RS02990	COG0439	Biotin carboxylase
MZHIL_RS03025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MZHIL_RS03035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MZHIL_RS03075	COG5012	cobalamin binding
MZHIL_RS03105	COG0590	tRNA wobble adenosine to inosine editing
MZHIL_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
MZHIL_RS03120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MZHIL_RS03130	COG2155	Conserved Protein
MZHIL_RS03155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MZHIL_RS03175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MZHIL_RS03180	COG0151	Belongs to the GarS family
MZHIL_RS03185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MZHIL_RS03200	COG1138	Cytochrome C-type biogenesis protein
MZHIL_RS03210	COG5012	cobalamin binding
MZHIL_RS03225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MZHIL_RS03230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MZHIL_RS03240	COG0473	3-isopropylmalate dehydrogenase activity
MZHIL_RS03245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MZHIL_RS03255	COG2197	response regulator
MZHIL_RS03280	COG0714	Associated with various cellular activities
MZHIL_RS03290	COG1605	Chorismate mutase
MZHIL_RS03290	COG0077	Prephenate dehydratase
MZHIL_RS03295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MZHIL_RS03345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZHIL_RS03360	COG0505	Belongs to the CarA family
MZHIL_RS03365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MZHIL_RS03370	COG0137	argininosuccinate synthase activity
MZHIL_RS03390	COG0372	Belongs to the citrate synthase family
MZHIL_RS03395	COG1301	dicarboxylic acid transport
MZHIL_RS03400	COG0189	ligase activity
MZHIL_RS03485	COG1793	dna ligase
MZHIL_RS03490	COG1796	DNA polymerase
MZHIL_RS03490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MZHIL_RS03495	COG0019	diaminopimelate decarboxylase activity
MZHIL_RS03500	COG1047	Peptidyl-prolyl cis-trans
MZHIL_RS03510	COG2095	MarC family integral membrane protein
MZHIL_RS03530	COG0746	molybdenum cofactor guanylyltransferase activity
MZHIL_RS03560	COG0396	ATPase activity
MZHIL_RS03570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MZHIL_RS03595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MZHIL_RS03600	COG1136	(ABC) transporter
MZHIL_RS03620	COG0492	ferredoxin-NADP+ reductase activity
MZHIL_RS03630	COG3875	lactate racemase activity
MZHIL_RS03635	COG0826	peptidase U32
MZHIL_RS03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MZHIL_RS03650	COG0535	radical SAM domain protein
MZHIL_RS03690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MZHIL_RS03705	COG0446	pyridine nucleotide-disulphide oxidoreductase
MZHIL_RS03730	COG0571	ribonuclease III activity
MZHIL_RS03735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MZHIL_RS03805	COG0129	dihydroxy-acid dehydratase activity
MZHIL_RS03810	COG0437	4 iron, 4 sulfur cluster binding
MZHIL_RS03825	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MZHIL_RS03870	COG0123	including yeast histone deacetylase and acetoin utilization protein
MZHIL_RS03900	COG0459	protein refolding
MZHIL_RS03910	COG1902	pentaerythritol trinitrate reductase activity
MZHIL_RS03910	COG0446	pyridine nucleotide-disulphide oxidoreductase
MZHIL_RS03915	COG2239	Acts as a magnesium transporter
MZHIL_RS03940	COG0312	modulator of DNA gyrase
MZHIL_RS03945	COG0312	modulator of DNA gyrase
MZHIL_RS03950	COG0470	DNA polymerase III
MZHIL_RS03950	COG1067	ATP-dependent peptidase activity
MZHIL_RS03965	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MZHIL_RS03965	COG0028	Belongs to the TPP enzyme family
MZHIL_RS03975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MZHIL_RS04000	COG0450	alkyl hydroperoxide reductase
MZHIL_RS04020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MZHIL_RS04060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MZHIL_RS04115	COG1047	Peptidyl-prolyl cis-trans
MZHIL_RS04140	COG2119	membrane
MZHIL_RS04160	COG2226	methyltransferase
MZHIL_RS04190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MZHIL_RS04195	COG0517	IMP dehydrogenase activity
MZHIL_RS04195	COG0617	tRNA 3'-terminal CCA addition
MZHIL_RS04195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MZHIL_RS04200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MZHIL_RS04205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MZHIL_RS04210	COG2873	o-acetylhomoserine
MZHIL_RS04220	COG2078	PFAM AMMECR1 domain protein
MZHIL_RS04220	COG3885	ferrous iron binding
MZHIL_RS04230	COG0126	phosphoglycerate kinase activity
MZHIL_RS04235	COG0857	belongs to the CobB CobQ family
MZHIL_RS04250	COG2133	pyrroloquinoline quinone binding
MZHIL_RS04255	COG3830	Belongs to the UPF0237 family
MZHIL_RS04260	COG2848	UPF0210 protein
MZHIL_RS04280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MZHIL_RS04285	COG1494	fructose-1,6-bisphosphatase
MZHIL_RS04295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MZHIL_RS04300	COG0495	leucyl-tRNA aminoacylation
MZHIL_RS04305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MZHIL_RS04330	COG5002	protein histidine kinase activity
MZHIL_RS04370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MZHIL_RS04375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MZHIL_RS04410	COG0460	homoserine dehydrogenase
MZHIL_RS04415	COG1793	dna ligase
MZHIL_RS04435	COG0513	Belongs to the DEAD box helicase family
MZHIL_RS04440	COG2226	methyltransferase
MZHIL_RS04445	COG0514	ATP-dependent DNA helicase (RecQ)
MZHIL_RS04470	COG1136	(ABC) transporter
MZHIL_RS04470	COG0577	efflux transmembrane transporter activity
MZHIL_RS04490	COG3402	PFAM membrane-flanked domain
MZHIL_RS04495	COG3428	Bacterial PH domain
MZHIL_RS04500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MZHIL_RS04510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MZHIL_RS04525	COG0436	Aminotransferase
MZHIL_RS04530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MZHIL_RS04530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MZHIL_RS04540	COG5002	protein histidine kinase activity
MZHIL_RS04545	COG0517	IMP dehydrogenase activity
MZHIL_RS04545	COG0516	GMP reductase activity
MZHIL_RS04550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MZHIL_RS04560	COG0628	permease
MZHIL_RS04580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MZHIL_RS04585	COG0674	pyruvate-flavodoxin oxidoreductase activity
MZHIL_RS04585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MZHIL_RS04595	COG0318	PFAM AMP-dependent synthetase and ligase
MZHIL_RS04635	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MZHIL_RS04660	COG0409	Hydrogenase expression formation protein
MZHIL_RS04670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MZHIL_RS04685	COG1983	PspC domain protein
MZHIL_RS04705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MZHIL_RS04715	COG0589	response to stress
MZHIL_RS04715	COG0475	glutathione-regulated potassium exporter activity
MZHIL_RS04730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MZHIL_RS04740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MZHIL_RS04775	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
MZHIL_RS04800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MZHIL_RS04805	COG1562	ergosterol biosynthetic process
MZHIL_RS04905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MZHIL_RS04910	COG1120	ATPase activity
MZHIL_RS04915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MZHIL_RS04920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MZHIL_RS04925	COG0534	Mate efflux family protein
MZHIL_RS04940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MZHIL_RS04950	COG1720	tRNA m6t6A37 methyltransferase activity
MZHIL_RS04955	COG0577	efflux transmembrane transporter activity
MZHIL_RS04955	COG1136	(ABC) transporter
MZHIL_RS04970	COG1136	(ABC) transporter
MZHIL_RS04975	COG4591	ABC-type transport system involved in lipoprotein release permease component
MZHIL_RS04985	COG1136	(ABC) transporter
MZHIL_RS04990	COG0577	efflux transmembrane transporter activity
MZHIL_RS05020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MZHIL_RS05020	COG0574	Belongs to the PEP-utilizing enzyme family
MZHIL_RS05030	COG2814	Major facilitator Superfamily
MZHIL_RS05035	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS05045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MZHIL_RS05050	COG0314	molybdopterin synthase activity
MZHIL_RS05060	COG2003	Belongs to the UPF0758 family
MZHIL_RS05100	COG1304	FMN binding
MZHIL_RS05115	COG1355	regulation of microtubule-based process
MZHIL_RS05120	COG0052	Belongs to the universal ribosomal protein uS2 family
MZHIL_RS05140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MZHIL_RS05145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MZHIL_RS05165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MZHIL_RS05170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MZHIL_RS05185	COG0589	response to stress
MZHIL_RS05190	COG4274	PFAM GYD family protein
MZHIL_RS05195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MZHIL_RS05225	COG2111	Na H antiporter
MZHIL_RS05225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MZHIL_RS05230	COG2111	Na H antiporter
MZHIL_RS05235	COG1006	Multisubunit Na H antiporter MnhC subunit
MZHIL_RS05240	COG0651	ATP synthesis coupled electron transport
MZHIL_RS05245	COG1863	multisubunit Na H antiporter MnhE subunit
MZHIL_RS05250	COG2212	antiporter activity
MZHIL_RS05255	COG1320	monovalent cation:proton antiporter activity
MZHIL_RS05260	COG0009	L-threonylcarbamoyladenylate synthase
MZHIL_RS05270	COG0425	Belongs to the sulfur carrier protein TusA family
MZHIL_RS05270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MZHIL_RS05275	COG1509	lysine 2,3-aminomutase activity
MZHIL_RS05300	COG0415	Belongs to the DNA photolyase family
MZHIL_RS05315	COG0281	malic enzyme
MZHIL_RS05325	COG1053	succinate dehydrogenase
MZHIL_RS05330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MZHIL_RS05360	COG1012	belongs to the aldehyde dehydrogenase family
MZHIL_RS05400	COG2166	iron-sulfur cluster assembly
MZHIL_RS05405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MZHIL_RS05410	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MZHIL_RS05415	COG2897	thiosulfate sulfurtransferase activity
MZHIL_RS05430	COG2814	Major facilitator Superfamily
MZHIL_RS05460	COG1151	hydroxylamine reductase activity
MZHIL_RS05475	COG0058	SHG alpha-glucan phosphorylase activity
MZHIL_RS05530	COG1489	DNA binding
MZHIL_RS05535	COG4106	trans-aconitate 2-methyltransferase activity
MZHIL_RS05540	COG1836	PFAM Integral membrane protein DUF92
MZHIL_RS05560	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MZHIL_RS05565	COG4608	Belongs to the ABC transporter superfamily
MZHIL_RS05570	COG0444	Belongs to the ABC transporter superfamily
MZHIL_RS05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MZHIL_RS05580	COG0601	transmembrane transport
MZHIL_RS05585	COG2226	methyltransferase
MZHIL_RS05590	COG0747	negative chemotaxis
MZHIL_RS05615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MZHIL_RS05620	COG0017	Asparaginyl-tRNA synthetase
MZHIL_RS05625	COG0252	asparaginase activity
MZHIL_RS05630	COG0165	Argininosuccinate lyase
MZHIL_RS05640	COG0436	Aminotransferase
MZHIL_RS05645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MZHIL_RS05660	COG0037	tRNA processing
MZHIL_RS05670	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MZHIL_RS05685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MZHIL_RS05690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MZHIL_RS05695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MZHIL_RS05700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MZHIL_RS05705	COG1418	mRNA catabolic process
MZHIL_RS05795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MZHIL_RS05800	COG1691	(AIR) carboxylase
MZHIL_RS05805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MZHIL_RS05810	COG0483	inositol monophosphate 1-phosphatase activity
MZHIL_RS05815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MZHIL_RS05850	COG3920	Histidine kinase
MZHIL_RS05885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MZHIL_RS05885	COG0574	Belongs to the PEP-utilizing enzyme family
MZHIL_RS05895	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MZHIL_RS05925	COG1185	polyribonucleotide nucleotidyltransferase activity
MZHIL_RS05930	COG1185	polyribonucleotide nucleotidyltransferase activity
MZHIL_RS05935	COG1185	polyribonucleotide nucleotidyltransferase activity
MZHIL_RS05980	COG5002	protein histidine kinase activity
MZHIL_RS05985	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MZHIL_RS06005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MZHIL_RS06015	COG0667	Aldo Keto reductase
MZHIL_RS06050	COG3153	acetyltransferase
MZHIL_RS06065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MZHIL_RS06070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MZHIL_RS06075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MZHIL_RS06095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MZHIL_RS06130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MZHIL_RS06155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MZHIL_RS06165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MZHIL_RS06180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MZHIL_RS06195	COG0255	Belongs to the universal ribosomal protein uL29 family
MZHIL_RS06200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MZHIL_RS06205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MZHIL_RS06210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MZHIL_RS06215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MZHIL_RS06230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MZHIL_RS06245	COG0284	orotidine-5'-phosphate decarboxylase activity
MZHIL_RS06250	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MZHIL_RS06255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MZHIL_RS06270	COG1201	RNA secondary structure unwinding
MZHIL_RS06280	COG1321	iron dependent repressor
MZHIL_RS06285	COG0697	spore germination
MZHIL_RS06300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MZHIL_RS06305	COG1116	anion transmembrane transporter activity
MZHIL_RS06320	COG0459	protein refolding
MZHIL_RS06325	COG2249	NAD(P)H dehydrogenase (quinone) activity
MZHIL_RS06330	COG0187	DNA topoisomerase II activity
MZHIL_RS06335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MZHIL_RS06340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MZHIL_RS06345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MZHIL_RS06355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MZHIL_RS06360	COG0105	UTP biosynthetic process
MZHIL_RS06380	COG0390	transport system, permease component
MZHIL_RS06385	COG1132	(ABC) transporter
MZHIL_RS06405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MZHIL_RS06420	COG1013	pyruvate-flavodoxin oxidoreductase activity
MZHIL_RS06425	COG2890	protein-(glutamine-N5) methyltransferase activity
MZHIL_RS06430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MZHIL_RS06460	COG4974	Belongs to the 'phage' integrase family
MZHIL_RS06490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS06550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MZHIL_RS06565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MZHIL_RS06570	COG0210	DNA helicase
MZHIL_RS06575	COG3593	DNA synthesis involved in DNA repair
MZHIL_RS06585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MZHIL_RS06675	COG0628	permease
MZHIL_RS06775	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MZHIL_RS06795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MZHIL_RS06800	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MZHIL_RS06825	COG0589	response to stress
MZHIL_RS06835	COG1587	Uroporphyrinogen-III synthase
MZHIL_RS06840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MZHIL_RS06840	COG1648	precorrin-2 dehydrogenase activity
MZHIL_RS06845	COG1215	transferase activity, transferring glycosyl groups
MZHIL_RS06860	COG4581	dead DEAH box helicase
MZHIL_RS06870	COG3769	mannosylglycerate metabolic process
MZHIL_RS06885	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MZHIL_RS06890	COG0351	phosphomethylpyrimidine kinase
MZHIL_RS06900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MZHIL_RS06915	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MZHIL_RS06925	COG0066	3-isopropylmalate dehydratase activity
MZHIL_RS06930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS06940	COG1234	tRNA 3'-trailer cleavage
MZHIL_RS06950	COG1522	sequence-specific DNA binding
MZHIL_RS06955	COG0436	Aminotransferase
MZHIL_RS06975	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS06990	COG0297	glycogen (starch) synthase activity
MZHIL_RS07005	COG0598	Magnesium transport protein CorA
MZHIL_RS07015	COG0668	transmembrane transport
MZHIL_RS07040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MZHIL_RS07045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MZHIL_RS07055	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MZHIL_RS07060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MZHIL_RS07075	COG0124	histidyl-tRNA synthetase
MZHIL_RS07115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MZHIL_RS07150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MZHIL_RS07150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MZHIL_RS07160	COG0179	Fumarylacetoacetate (FAA) hydrolase
MZHIL_RS07210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MZHIL_RS07225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MZHIL_RS07280	COG2205	protein histidine kinase activity
MZHIL_RS07280	COG2202	Pas domain
MZHIL_RS07295	COG0590	tRNA wobble adenosine to inosine editing
MZHIL_RS07300	COG0778	Nitroreductase
MZHIL_RS07305	COG1741	Belongs to the pirin family
MZHIL_RS07340	COG0778	Nitroreductase
MZHIL_RS07345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MZHIL_RS07360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MZHIL_RS07365	COG1121	(ABC) transporter
MZHIL_RS07370	COG0803	Belongs to the bacterial solute-binding protein 9 family
MZHIL_RS07415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MZHIL_RS07425	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MZHIL_RS07455	COG1269	ATP hydrolysis coupled proton transport
MZHIL_RS07465	COG0535	radical SAM domain protein
MZHIL_RS07470	COG0142	geranyltranstransferase activity
MZHIL_RS07480	COG0535	radical SAM domain protein
MZHIL_RS07490	COG1522	sequence-specific DNA binding
MZHIL_RS07495	COG1648	precorrin-2 dehydrogenase activity
MZHIL_RS07495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MZHIL_RS07500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MZHIL_RS07505	COG0113	porphobilinogen synthase activity
MZHIL_RS07510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MZHIL_RS07515	COG0181	hydroxymethylbilane synthase activity
MZHIL_RS07520	COG0167	dihydroorotate dehydrogenase activity
MZHIL_RS07545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS07570	COG0556	nucleotide-excision repair
MZHIL_RS07595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MZHIL_RS07605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MZHIL_RS07650	COG5012	cobalamin binding
MZHIL_RS07675	COG5012	cobalamin binding
MZHIL_RS07695	COG0745	RESPONSE REGULATOR receiver
MZHIL_RS07700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MZHIL_RS07705	COG2226	methyltransferase
MZHIL_RS07730	COG1032	radical SAM domain protein
MZHIL_RS07755	COG0693	protein deglycase activity
MZHIL_RS07765	COG1151	hydroxylamine reductase activity
MZHIL_RS07770	COG1733	regulation of RNA biosynthetic process
MZHIL_RS07775	COG0426	domain, Protein
MZHIL_RS07785	COG1397	ADP-ribosylglycohydrolase
MZHIL_RS07810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MZHIL_RS07815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MZHIL_RS07820	COG1518	maintenance of DNA repeat elements
MZHIL_RS07835	COG1857	crispr-associated protein
MZHIL_RS07850	COG1203	CRISPR-associated helicase, Cas3
MZHIL_RS07875	COG2144	transferase activity, transferring acyl groups
MZHIL_RS07880	COG0535	radical SAM domain protein
MZHIL_RS07890	COG0602	queuosine metabolic process
MZHIL_RS07900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MZHIL_RS07940	COG0189	ligase activity
MZHIL_RS07940	COG0569	domain protein
MZHIL_RS07955	COG0585	pseudouridine synthase activity
MZHIL_RS07960	COG0504	CTP synthase activity
MZHIL_RS07970	COG2835	tetraacyldisaccharide 4'-kinase activity
MZHIL_RS07990	COG1007	ATP synthesis coupled electron transport
MZHIL_RS08040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZHIL_RS08045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZHIL_RS08060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MZHIL_RS08065	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MZHIL_RS08095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MZHIL_RS08100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MZHIL_RS08105	COG0569	domain protein
MZHIL_RS08110	COG0484	heat shock protein binding
MZHIL_RS08115	COG0443	Heat shock 70 kDa protein
MZHIL_RS08120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MZHIL_RS08185	COG0534	Mate efflux family protein
MZHIL_RS08190	COG0301	tRNA thio-modification
MZHIL_RS08195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MZHIL_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
MZHIL_RS08210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MZHIL_RS08235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MZHIL_RS08235	COG0662	Cupin 2, conserved barrel domain protein
MZHIL_RS08240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MZHIL_RS08250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MZHIL_RS08285	COG0438	transferase activity, transferring glycosyl groups
MZHIL_RS08305	COG0438	transferase activity, transferring glycosyl groups
MZHIL_RS08315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MZHIL_RS08320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MZHIL_RS08325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MZHIL_RS08345	COG0066	3-isopropylmalate dehydratase activity
MZHIL_RS08355	COG0473	3-isopropylmalate dehydrogenase activity
MZHIL_RS08370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MZHIL_RS08395	COG0745	RESPONSE REGULATOR receiver
MZHIL_RS08400	COG0745	RESPONSE REGULATOR receiver
MZHIL_RS08405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MZHIL_RS08410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MZHIL_RS08450	COG0688	phosphatidylethanolamine metabolic process
MZHIL_RS08455	COG1183	phosphatidylcholine synthase activity
MZHIL_RS08460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MZHIL_RS08470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MZHIL_RS08475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MZHIL_RS08520	COG0753	catalase activity
MZHIL_RS08570	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MZHIL_RS08575	COG1078	dGTPase activity
MZHIL_RS08580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MZHIL_RS08605	COG4175	Glycine betaine
MZHIL_RS08605	COG0517	IMP dehydrogenase activity
MZHIL_RS08665	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MZHIL_RS08685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MZHIL_RS08700	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MZHIL_RS08705	COG0071	Belongs to the small heat shock protein (HSP20) family
MZHIL_RS08710	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MZHIL_RS08710	COG0778	Nitroreductase
MZHIL_RS08720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MZHIL_RS08725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MZHIL_RS08730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MZHIL_RS08790	COG0322	excinuclease ABC activity
MZHIL_RS08805	COG0039	L-malate dehydrogenase activity
MZHIL_RS08825	COG0864	Transcriptional regulator
MZHIL_RS08830	COG0640	Transcriptional regulator
MZHIL_RS08835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MZHIL_RS08865	COG0426	domain, Protein
MZHIL_RS08875	COG1260	myo-inositol-1-phosphate synthase
MZHIL_RS08890	COG1592	Rubrerythrin
MZHIL_RS08895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MZHIL_RS08895	COG1017	nitric oxide dioxygenase activity
MZHIL_RS08900	COG0431	NADPH-dependent FMN reductase
MZHIL_RS08940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MZHIL_RS08980	COG1309	transcriptional regulator
MZHIL_RS08985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MZHIL_RS09010	COG2205	protein histidine kinase activity
MZHIL_RS09020	COG5012	cobalamin binding
MZHIL_RS09035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MZHIL_RS09040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MZHIL_RS09045	COG5002	protein histidine kinase activity
MZHIL_RS09050	COG1722	exodeoxyribonuclease VII activity
MZHIL_RS09055	COG1570	exodeoxyribonuclease VII activity
MZHIL_RS09085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MZHIL_RS09090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MZHIL_RS09100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MZHIL_RS09120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MZHIL_RS09125	COG1606	tRNA processing
MZHIL_RS09165	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZHIL_RS09185	COG0521	Mo-molybdopterin cofactor biosynthetic process
MZHIL_RS09200	COG1993	acr, cog1993
MZHIL_RS09205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MZHIL_RS09210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MZHIL_RS09215	COG0303	'Molybdopterin
MZHIL_RS09220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MZHIL_RS09230	COG0842	Transport permease protein
MZHIL_RS09235	COG0163	prenyltransferase activity
MZHIL_RS09245	COG1078	dGTPase activity
MZHIL_RS09250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MZHIL_RS09255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MZHIL_RS09265	COG2264	protein methyltransferase activity
MZHIL_RS09285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MZHIL_RS09290	COG0004	ammonium transporteR
MZHIL_RS09295	COG0347	Belongs to the P(II) protein family
MZHIL_RS09305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MZHIL_RS09320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MZHIL_RS09340	COG0822	iron-sulfur transferase activity
MZHIL_RS09345	COG1104	cysteine desulfurase activity
MZHIL_RS09360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MZHIL_RS09365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MZHIL_RS09375	COG1917	Cupin 2, conserved barrel domain protein
MZHIL_RS09385	COG0616	signal peptide processing
MZHIL_RS09390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MZHIL_RS09390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MZHIL_RS09430	COG0138	bifunctional purine biosynthesis protein purh
MZHIL_RS09435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MZHIL_RS09440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MZHIL_RS09500	COG4172	Belongs to the ABC transporter superfamily
MZHIL_RS09510	COG5549	protein import
MZHIL_RS09510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MZHIL_RS09515	COG2169	Transcriptional regulator
MZHIL_RS09515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MZHIL_RS09525	COG0010	Belongs to the arginase family
MZHIL_RS09535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MZHIL_RS09545	COG0107	imidazoleglycerol-phosphate synthase activity
MZHIL_RS09550	COG0826	peptidase U32
MZHIL_RS09565	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MZHIL_RS09570	COG1945	arginine decarboxylase activity
MZHIL_RS09595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MZHIL_RS09610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MZHIL_RS09610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MZHIL_RS09625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MZHIL_RS09630	COG0140	phosphoribosyl-ATP diphosphatase activity
MZHIL_RS09640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MZHIL_RS09650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MZHIL_RS09675	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MZHIL_RS09680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZHIL_RS09690	COG0561	phosphatase activity
MZHIL_RS09715	COG1122	ATPase activity
MZHIL_RS09735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MZHIL_RS09745	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MZHIL_RS09750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MZHIL_RS09755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MZHIL_RS09770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MZHIL_RS09775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MZHIL_RS09780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MZHIL_RS09785	COG0655	NAD(P)H dehydrogenase (quinone) activity
MZHIL_RS09800	COG5012	cobalamin binding
MZHIL_RS09810	COG1410	methionine synthase
MZHIL_RS09810	COG0646	methionine synthase
MZHIL_RS09815	COG4191	Histidine kinase
MZHIL_RS09820	COG0523	cobalamin synthesis protein
MZHIL_RS09830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MZHIL_RS09835	COG0215	cysteine-tRNA ligase activity
MZHIL_RS09840	COG0842	Transport permease protein
MZHIL_RS09845	COG1131	(ABC) transporter
MZHIL_RS09865	COG1331	Highly conserved protein containing a thioredoxin domain
MZHIL_RS09895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MZHIL_RS09940	COG0528	UMP kinase activity
MZHIL_RS09950	COG1012	belongs to the aldehyde dehydrogenase family
MZHIL_RS09970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MZHIL_RS09985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MZHIL_RS09990	COG0081	regulation of translation
MZHIL_RS10005	COG0535	radical SAM domain protein
MZHIL_RS10010	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
MZHIL_RS10015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MZHIL_RS10040	COG1196	nuclear chromosome segregation
MZHIL_RS10050	COG1196	nuclear chromosome segregation
MZHIL_RS10055	COG0420	3'-5' exonuclease activity
MZHIL_RS10070	COG0433	COG0433 Predicted ATPase
MZHIL_RS10105	COG0589	response to stress
MZHIL_RS10125	COG0674	pyruvate-flavodoxin oxidoreductase activity
MZHIL_RS10130	COG1013	pyruvate-flavodoxin oxidoreductase activity
MZHIL_RS10135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MZHIL_RS10140	COG1045	serine acetyltransferase
MZHIL_RS10150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MZHIL_RS10160	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MZHIL_RS10175	COG0076	glutamate decarboxylase activity
MZHIL_RS10190	COG5000	phosphorelay sensor kinase activity
MZHIL_RS10200	COG5002	protein histidine kinase activity
MZHIL_RS10205	COG5002	protein histidine kinase activity
MZHIL_RS10210	COG1846	Transcriptional regulator
MZHIL_RS10230	COG5002	protein histidine kinase activity
MZHIL_RS10295	COG3794	PFAM blue (type 1) copper domain protein