locus-tag	class	description
MSLAZ_RS00055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MSLAZ_RS00055	COG0617	tRNA 3'-terminal CCA addition
MSLAZ_RS00055	COG0517	IMP dehydrogenase activity
MSLAZ_RS00075	COG0517	IMP dehydrogenase activity
MSLAZ_RS00100	COG0430	RNA-3'-phosphate cyclase activity
MSLAZ_RS00105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSLAZ_RS00120	COG0456	acetyltransferase
MSLAZ_RS00130	COG0277	FAD linked oxidase domain protein
MSLAZ_RS00135	COG0247	lactate metabolic process
MSLAZ_RS00135	COG2181	nitrate reductase activity
MSLAZ_RS00165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSLAZ_RS00170	COG0084	hydrolase, TatD family'
MSLAZ_RS00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSLAZ_RS00210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSLAZ_RS00215	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSLAZ_RS00240	COG1605	Chorismate mutase
MSLAZ_RS00240	COG0287	Prephenate dehydrogenase
MSLAZ_RS00245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSLAZ_RS00250	COG0710	3-dehydroquinate dehydratase activity
MSLAZ_RS00255	COG1465	3-dehydroquinate synthase
MSLAZ_RS00260	COG1830	Aldolase
MSLAZ_RS00265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSLAZ_RS00265	COG0519	Catalyzes the synthesis of GMP from XMP
MSLAZ_RS00270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSLAZ_RS00355	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MSLAZ_RS00355	COG0662	Cupin 2, conserved barrel domain protein
MSLAZ_RS00360	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSLAZ_RS00365	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS00385	COG3842	ATPase activity
MSLAZ_RS00390	COG4208	sulfate ABC transporter
MSLAZ_RS00395	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSLAZ_RS00400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSLAZ_RS00445	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSLAZ_RS00470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSLAZ_RS00475	COG0235	Class ii aldolase
MSLAZ_RS00490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSLAZ_RS00510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MSLAZ_RS00515	COG0372	Belongs to the citrate synthase family
MSLAZ_RS00540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSLAZ_RS00545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSLAZ_RS00550	COG1606	tRNA processing
MSLAZ_RS00555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSLAZ_RS00555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSLAZ_RS00565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSLAZ_RS00615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSLAZ_RS00625	COG0131	Imidazoleglycerol-phosphate dehydratase
MSLAZ_RS00630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSLAZ_RS00635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSLAZ_RS00640	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSLAZ_RS00670	COG0024	Methionine aminopeptidase
MSLAZ_RS00680	COG3377	Domain of unknown function (DUF1805)
MSLAZ_RS00695	COG0101	tRNA pseudouridine synthase activity
MSLAZ_RS00705	COG0519	Catalyzes the synthesis of GMP from XMP
MSLAZ_RS00705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSLAZ_RS00715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSLAZ_RS00725	COG1469	GTP cyclohydrolase I activity
MSLAZ_RS00750	COG0154	amidase activity
MSLAZ_RS00755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSLAZ_RS00765	COG2226	methyltransferase
MSLAZ_RS00770	COG1120	ATPase activity
MSLAZ_RS00775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSLAZ_RS00790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSLAZ_RS00800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MSLAZ_RS00805	COG1715	Restriction endonuclease
MSLAZ_RS00810	COG0501	Belongs to the peptidase M48B family
MSLAZ_RS00815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSLAZ_RS00820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSLAZ_RS00895	COG0009	L-threonylcarbamoyladenylate synthase
MSLAZ_RS00900	COG1850	ribulose-bisphosphate carboxylase activity
MSLAZ_RS00920	COG0577	efflux transmembrane transporter activity
MSLAZ_RS00925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSLAZ_RS00930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSLAZ_RS00935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSLAZ_RS00955	COG1830	Aldolase
MSLAZ_RS00980	COG0523	cobalamin synthesis protein
MSLAZ_RS01000	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MSLAZ_RS01005	COG1691	(AIR) carboxylase
MSLAZ_RS01010	COG0528	UMP kinase activity
MSLAZ_RS01020	COG1136	(ABC) transporter
MSLAZ_RS01020	COG0577	efflux transmembrane transporter activity
MSLAZ_RS01025	COG1136	(ABC) transporter
MSLAZ_RS01030	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSLAZ_RS01055	COG2304	oxidoreductase activity
MSLAZ_RS01145	COG0534	Mate efflux family protein
MSLAZ_RS01150	COG1733	regulation of RNA biosynthetic process
MSLAZ_RS01175	COG1091	dTDP-4-dehydrorhamnose reductase activity
MSLAZ_RS01210	COG3842	ATPase activity
MSLAZ_RS01255	COG5012	cobalamin binding
MSLAZ_RS01270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSLAZ_RS01285	COG1320	monovalent cation:proton antiporter activity
MSLAZ_RS01295	COG1863	multisubunit Na H antiporter MnhE subunit
MSLAZ_RS01300	COG0651	ATP synthesis coupled electron transport
MSLAZ_RS01305	COG1006	Multisubunit Na H antiporter MnhC subunit
MSLAZ_RS01310	COG2111	Na H antiporter
MSLAZ_RS01315	COG2111	Na H antiporter
MSLAZ_RS01315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSLAZ_RS01330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS01400	COG1229	Formylmethanofuran dehydrogenase subunit A
MSLAZ_RS01415	COG0243	molybdopterin cofactor binding
MSLAZ_RS01425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSLAZ_RS01450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MSLAZ_RS01500	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MSLAZ_RS01505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSLAZ_RS01510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSLAZ_RS01515	COG0390	transport system, permease component
MSLAZ_RS01530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSLAZ_RS01540	COG0247	lactate metabolic process
MSLAZ_RS01540	COG2181	nitrate reductase activity
MSLAZ_RS01545	COG5012	cobalamin binding
MSLAZ_RS01560	COG5012	cobalamin binding
MSLAZ_RS01605	COG3613	nucleoside 2-deoxyribosyltransferase
MSLAZ_RS01610	COG0826	peptidase U32
MSLAZ_RS01625	COG0107	imidazoleglycerol-phosphate synthase activity
MSLAZ_RS01640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSLAZ_RS01660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSLAZ_RS01660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSLAZ_RS01665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSLAZ_RS01670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSLAZ_RS01690	COG0535	radical SAM domain protein
MSLAZ_RS01700	COG1522	sequence-specific DNA binding
MSLAZ_RS01705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSLAZ_RS01705	COG1648	precorrin-2 dehydrogenase activity
MSLAZ_RS01710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSLAZ_RS01715	COG0113	porphobilinogen synthase activity
MSLAZ_RS01725	COG0181	hydroxymethylbilane synthase activity
MSLAZ_RS01730	COG0167	dihydroorotate dehydrogenase activity
MSLAZ_RS01735	COG0543	2 iron, 2 sulfur cluster binding
MSLAZ_RS01740	COG0179	Fumarylacetoacetate (FAA) hydrolase
MSLAZ_RS01770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MSLAZ_RS01785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSLAZ_RS01790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSLAZ_RS01805	COG0052	Belongs to the universal ribosomal protein uS2 family
MSLAZ_RS01810	COG1355	regulation of microtubule-based process
MSLAZ_RS01815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MSLAZ_RS01825	COG1304	FMN binding
MSLAZ_RS01840	COG0142	geranyltranstransferase activity
MSLAZ_RS01855	COG0574	Belongs to the PEP-utilizing enzyme family
MSLAZ_RS01855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSLAZ_RS01910	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSLAZ_RS01920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSLAZ_RS01925	COG0459	protein refolding
MSLAZ_RS01960	COG0765	amino acid transport
MSLAZ_RS01965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSLAZ_RS01975	COG1739	Uncharacterized protein family UPF0029
MSLAZ_RS02005	COG0784	Response regulator, receiver
MSLAZ_RS02005	COG2205	protein histidine kinase activity
MSLAZ_RS02025	COG1247	-acetyltransferase
MSLAZ_RS02115	COG1185	polyribonucleotide nucleotidyltransferase activity
MSLAZ_RS02120	COG2264	protein methyltransferase activity
MSLAZ_RS02130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSLAZ_RS02140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MSLAZ_RS02145	COG1078	dGTPase activity
MSLAZ_RS02155	COG0163	prenyltransferase activity
MSLAZ_RS02210	COG0747	negative chemotaxis
MSLAZ_RS02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSLAZ_RS02225	COG0444	Belongs to the ABC transporter superfamily
MSLAZ_RS02230	COG4608	Belongs to the ABC transporter superfamily
MSLAZ_RS02235	COG1144	Oxidoreductase
MSLAZ_RS02260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MSLAZ_RS02275	COG0247	lactate metabolic process
MSLAZ_RS02275	COG2181	nitrate reductase activity
MSLAZ_RS02285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSLAZ_RS02335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSLAZ_RS02335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSLAZ_RS02340	COG0439	Biotin carboxylase
MSLAZ_RS02345	COG5016	pyruvate
MSLAZ_RS02345	COG0511	ligase activity, forming carbon-carbon bonds
MSLAZ_RS02375	COG2255	four-way junction helicase activity
MSLAZ_RS02385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MSLAZ_RS02440	COG4657	Part of a membrane complex involved in electron transport
MSLAZ_RS02445	COG4660	Part of a membrane complex involved in electron transport
MSLAZ_RS02450	COG4659	FMN binding
MSLAZ_RS02455	COG4658	electron transport chain
MSLAZ_RS02460	COG4656	Part of a membrane complex involved in electron transport
MSLAZ_RS02470	COG1477	protein flavinylation
MSLAZ_RS02475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MSLAZ_RS02500	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MSLAZ_RS02540	COG1185	polyribonucleotide nucleotidyltransferase activity
MSLAZ_RS02565	COG1592	Rubrerythrin
MSLAZ_RS02590	COG1215	transferase activity, transferring glycosyl groups
MSLAZ_RS02595	COG0640	Transcriptional regulator
MSLAZ_RS02600	COG0864	Transcriptional regulator
MSLAZ_RS02635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSLAZ_RS02640	COG2155	Conserved Protein
MSLAZ_RS02650	COG0321	lipoyl(octanoyl) transferase activity
MSLAZ_RS02650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSLAZ_RS02655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS02660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSLAZ_RS02690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSLAZ_RS02715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSLAZ_RS02720	COG0616	signal peptide processing
MSLAZ_RS02725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSLAZ_RS02725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSLAZ_RS02740	COG0183	Belongs to the thiolase family
MSLAZ_RS02800	COG1122	ATPase activity
MSLAZ_RS02810	COG0310	cobalt ion transport
MSLAZ_RS02820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSLAZ_RS02830	COG0138	bifunctional purine biosynthesis protein purh
MSLAZ_RS02845	COG0500	methyltransferase
MSLAZ_RS02850	COG1584	GPR1 FUN34 yaaH family protein
MSLAZ_RS02855	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSLAZ_RS02870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSLAZ_RS02895	COG2217	Heavy metal translocating P-type atpase
MSLAZ_RS02900	COG1122	ATPase activity
MSLAZ_RS02940	COG5549	protein import
MSLAZ_RS02940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSLAZ_RS02945	COG0494	nUDIX hydrolase
MSLAZ_RS02960	COG0010	Belongs to the arginase family
MSLAZ_RS02970	COG3620	sequence-specific DNA binding
MSLAZ_RS02990	COG1509	lysine 2,3-aminomutase activity
MSLAZ_RS02995	COG0456	acetyltransferase
MSLAZ_RS03005	COG4962	Type ii secretion system protein e
MSLAZ_RS03010	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSLAZ_RS03025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MSLAZ_RS03065	COG0577	efflux transmembrane transporter activity
MSLAZ_RS03070	COG2205	protein histidine kinase activity
MSLAZ_RS03080	COG1136	(ABC) transporter
MSLAZ_RS03090	COG0577	efflux transmembrane transporter activity
MSLAZ_RS03100	COG1136	(ABC) transporter
MSLAZ_RS03110	COG0513	Belongs to the DEAD box helicase family
MSLAZ_RS03150	COG0785	Cytochrome C biogenesis protein
MSLAZ_RS03160	COG0589	response to stress
MSLAZ_RS03185	COG0640	Transcriptional regulator
MSLAZ_RS03215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSLAZ_RS03215	COG0730	response to heat
MSLAZ_RS03250	COG0004	ammonium transporteR
MSLAZ_RS03255	COG0347	Belongs to the P(II) protein family
MSLAZ_RS03275	COG0644	oxidoreductase
MSLAZ_RS03290	COG0469	pyruvate kinase activity
MSLAZ_RS03325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSLAZ_RS03330	COG0442	prolyl-tRNA aminoacylation
MSLAZ_RS03355	COG2814	Major facilitator Superfamily
MSLAZ_RS03360	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSLAZ_RS03375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSLAZ_RS03380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSLAZ_RS03385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSLAZ_RS03475	COG0436	Aminotransferase
MSLAZ_RS03480	COG1522	sequence-specific DNA binding
MSLAZ_RS03515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSLAZ_RS03540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSLAZ_RS03565	COG0028	Belongs to the TPP enzyme family
MSLAZ_RS03570	COG1012	belongs to the aldehyde dehydrogenase family
MSLAZ_RS03600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSLAZ_RS03605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSLAZ_RS03635	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSLAZ_RS03660	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MSLAZ_RS03675	COG0730	response to heat
MSLAZ_RS03685	COG2205	protein histidine kinase activity
MSLAZ_RS03685	COG2202	Pas domain
MSLAZ_RS03695	COG0519	Catalyzes the synthesis of GMP from XMP
MSLAZ_RS03695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSLAZ_RS03700	COG2226	methyltransferase
MSLAZ_RS03705	COG1494	fructose-1,6-bisphosphatase
MSLAZ_RS03710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSLAZ_RS03740	COG1592	Rubrerythrin
MSLAZ_RS03770	COG0420	3'-5' exonuclease activity
MSLAZ_RS03775	COG1196	nuclear chromosome segregation
MSLAZ_RS03805	COG0315	cyclic pyranopterin monophosphate synthase activity
MSLAZ_RS03815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSLAZ_RS03815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSLAZ_RS03830	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS03835	COG1682	transport, permease protein
MSLAZ_RS03890	COG0463	Glycosyl transferase, family 2
MSLAZ_RS03905	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS03920	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSLAZ_RS03945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS03970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSLAZ_RS03975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSLAZ_RS03980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSLAZ_RS03985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSLAZ_RS04010	COG3118	belongs to the thioredoxin family
MSLAZ_RS04040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSLAZ_RS04060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MSLAZ_RS04080	COG1418	mRNA catabolic process
MSLAZ_RS04085	COG0402	S-adenosylhomocysteine deaminase activity
MSLAZ_RS04090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSLAZ_RS04095	COG3447	MASE1 domain protein
MSLAZ_RS04095	COG5001	Diguanylate cyclase
MSLAZ_RS04095	COG5002	protein histidine kinase activity
MSLAZ_RS04110	COG0085	RNA polymerase activity
MSLAZ_RS04115	COG0085	RNA polymerase activity
MSLAZ_RS04120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSLAZ_RS04125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSLAZ_RS04145	COG0049	tRNA binding
MSLAZ_RS04150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MSLAZ_RS04155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSLAZ_RS04185	COG2361	Protein of unknown function DUF86
MSLAZ_RS04205	COG4467	Involved in initiation control of chromosome replication
MSLAZ_RS04280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MSLAZ_RS04330	COG1122	ATPase activity
MSLAZ_RS04335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSLAZ_RS04350	COG0318	PFAM AMP-dependent synthetase and ligase
MSLAZ_RS04370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSLAZ_RS04380	COG4555	ABC transporter
MSLAZ_RS04385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSLAZ_RS04475	COG0187	DNA topoisomerase II activity
MSLAZ_RS04480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MSLAZ_RS04490	COG2361	Protein of unknown function DUF86
MSLAZ_RS04510	COG0412	Dienelactone hydrolase
MSLAZ_RS04520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSLAZ_RS04550	COG0671	phosphoesterase, PA-phosphatase related
MSLAZ_RS04560	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MSLAZ_RS04565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MSLAZ_RS04635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSLAZ_RS04640	COG0105	UTP biosynthetic process
MSLAZ_RS04675	COG2816	NAD+ diphosphatase activity
MSLAZ_RS04680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSLAZ_RS04685	COG2890	protein-(glutamine-N5) methyltransferase activity
MSLAZ_RS04690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSLAZ_RS04725	COG3174	membrane
MSLAZ_RS04755	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MSLAZ_RS04805	COG0301	tRNA thio-modification
MSLAZ_RS04820	COG0745	RESPONSE REGULATOR receiver
MSLAZ_RS04875	COG0697	spore germination
MSLAZ_RS04880	COG1945	arginine decarboxylase activity
MSLAZ_RS04905	COG1451	nucleotide metabolic process
MSLAZ_RS04940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSLAZ_RS04945	COG1793	dna ligase
MSLAZ_RS04950	COG0460	homoserine dehydrogenase
MSLAZ_RS05040	COG0546	phosphoglycolate phosphatase activity
MSLAZ_RS05060	COG0492	ferredoxin-NADP+ reductase activity
MSLAZ_RS05090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSLAZ_RS05105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSLAZ_RS05130	COG0481	GTPase activity
MSLAZ_RS05145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSLAZ_RS05150	COG0436	Aminotransferase
MSLAZ_RS05160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSLAZ_RS05170	COG0140	phosphoribosyl-ATP diphosphatase activity
MSLAZ_RS05225	COG0444	Belongs to the ABC transporter superfamily
MSLAZ_RS05230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSLAZ_RS05240	COG2226	methyltransferase
MSLAZ_RS05250	COG0747	negative chemotaxis
MSLAZ_RS05280	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MSLAZ_RS05300	COG3875	lactate racemase activity
MSLAZ_RS05305	COG4145	pantothenate transmembrane transporter activity
MSLAZ_RS05310	COG0252	asparaginase activity
MSLAZ_RS05315	COG0165	Argininosuccinate lyase
MSLAZ_RS05345	COG0298	carbon dioxide binding
MSLAZ_RS05350	COG0409	Hydrogenase expression formation protein
MSLAZ_RS05370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSLAZ_RS05370	COG2111	Na H antiporter
MSLAZ_RS05375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSLAZ_RS05380	COG3260	NADH ubiquinone oxidoreductase 20
MSLAZ_RS05390	COG0649	NAD binding
MSLAZ_RS05420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MSLAZ_RS05430	COG2608	mercury ion transmembrane transporter activity
MSLAZ_RS05450	COG4895	conserved protein (DUF2196)
MSLAZ_RS05505	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSLAZ_RS05510	COG0826	peptidase U32
MSLAZ_RS05525	COG0426	domain, Protein
MSLAZ_RS05535	COG0653	protein targeting
MSLAZ_RS05545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSLAZ_RS05545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSLAZ_RS05565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MSLAZ_RS05575	COG0281	malic enzyme
MSLAZ_RS05670	COG1047	Peptidyl-prolyl cis-trans
MSLAZ_RS05680	COG0456	acetyltransferase
MSLAZ_RS05685	COG0456	acetyltransferase
MSLAZ_RS05720	COG0590	tRNA wobble adenosine to inosine editing
MSLAZ_RS05730	COG0574	Belongs to the PEP-utilizing enzyme family
MSLAZ_RS05730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSLAZ_RS05745	COG0004	ammonium transporteR
MSLAZ_RS05790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSLAZ_RS05840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MSLAZ_RS05850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSLAZ_RS05875	COG3328	transposase activity
MSLAZ_RS05925	COG0667	Aldo Keto reductase
MSLAZ_RS05965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS06025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MSLAZ_RS06030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MSLAZ_RS06035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MSLAZ_RS06045	COG0356	it plays a direct role in the translocation of protons across the membrane
MSLAZ_RS06065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MSLAZ_RS06070	COG2153	protein acetylation
MSLAZ_RS06100	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSLAZ_RS06130	COG2409	Drug exporters of the RND superfamily
MSLAZ_RS06135	COG1846	Transcriptional regulator
MSLAZ_RS06140	COG0569	domain protein
MSLAZ_RS06165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSLAZ_RS06205	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MSLAZ_RS06245	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSLAZ_RS06250	COG1846	Transcriptional regulator
MSLAZ_RS06260	COG1136	(ABC) transporter
MSLAZ_RS06270	COG1136	(ABC) transporter
MSLAZ_RS06270	COG0577	efflux transmembrane transporter activity
MSLAZ_RS06290	COG1945	arginine decarboxylase activity
MSLAZ_RS06295	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSLAZ_RS06410	COG0210	DNA helicase
MSLAZ_RS06410	COG0210	DNA helicase
MSLAZ_RS06425	COG2361	Protein of unknown function DUF86
MSLAZ_RS06455	COG1598	PFAM Uncharacterised protein family UPF0150
MSLAZ_RS06480	COG0137	argininosuccinate synthase activity
MSLAZ_RS06485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSLAZ_RS06490	COG0505	Belongs to the CarA family
MSLAZ_RS06495	COG0517	IMP dehydrogenase activity
MSLAZ_RS06495	COG4175	Glycine betaine
MSLAZ_RS06550	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MSLAZ_RS06560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MSLAZ_RS06575	COG1846	Transcriptional regulator
MSLAZ_RS06655	COG0148	phosphopyruvate hydratase activity
MSLAZ_RS06670	COG1136	(ABC) transporter
MSLAZ_RS06735	COG1174	glycine betaine transport
MSLAZ_RS06740	COG1125	glycine betaine transport
MSLAZ_RS06740	COG0517	IMP dehydrogenase activity
MSLAZ_RS06745	COG1732	Glycine betaine
MSLAZ_RS06750	COG0530	calcium, potassium:sodium antiporter activity
MSLAZ_RS06755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSLAZ_RS06760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSLAZ_RS06765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSLAZ_RS06770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSLAZ_RS06785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS06795	COG0463	Glycosyl transferase, family 2
MSLAZ_RS06800	COG0110	maltose O-acetyltransferase activity
MSLAZ_RS06845	COG1234	tRNA 3'-trailer cleavage
MSLAZ_RS06865	COG0535	radical SAM domain protein
MSLAZ_RS06870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MSLAZ_RS06925	COG0693	protein deglycase activity
MSLAZ_RS06935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MSLAZ_RS06960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MSLAZ_RS07010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSLAZ_RS07035	COG1115	amino acid carrier protein
MSLAZ_RS07050	COG1136	(ABC) transporter
MSLAZ_RS07060	COG1136	(ABC) transporter
MSLAZ_RS07060	COG0577	efflux transmembrane transporter activity
MSLAZ_RS07070	COG0714	Associated with various cellular activities
MSLAZ_RS07150	COG1598	PFAM Uncharacterised protein family UPF0150
MSLAZ_RS07160	COG1598	PFAM Uncharacterised protein family UPF0150
MSLAZ_RS07195	COG2361	Protein of unknown function DUF86
MSLAZ_RS07230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSLAZ_RS07270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS07290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSLAZ_RS07315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MSLAZ_RS07325	COG0495	leucyl-tRNA aminoacylation
MSLAZ_RS07335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MSLAZ_RS07350	COG5012	cobalamin binding
MSLAZ_RS07375	COG0463	Glycosyl transferase, family 2
MSLAZ_RS07400	COG4804	nuclease activity
MSLAZ_RS07440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSLAZ_RS07450	COG0588	phosphoglycerate mutase activity
MSLAZ_RS07500	COG0668	transmembrane transport
MSLAZ_RS07545	COG0598	Magnesium transport protein CorA
MSLAZ_RS07575	COG2414	aldehyde ferredoxin oxidoreductase
MSLAZ_RS07590	COG0436	Aminotransferase
MSLAZ_RS07605	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MSLAZ_RS07610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSLAZ_RS07615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSLAZ_RS07620	COG0805	protein transport
MSLAZ_RS07625	COG0805	protein transport
MSLAZ_RS07640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MSLAZ_RS07645	COG0443	Heat shock 70 kDa protein
MSLAZ_RS07650	COG0484	heat shock protein binding
MSLAZ_RS07705	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSLAZ_RS07715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSLAZ_RS07735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSLAZ_RS07740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSLAZ_RS07745	COG0649	NAD binding
MSLAZ_RS07750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSLAZ_RS07770	COG0713	ATP synthesis coupled electron transport
MSLAZ_RS07780	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSLAZ_RS07785	COG1007	ATP synthesis coupled electron transport
MSLAZ_RS07825	COG1151	hydroxylamine reductase activity
MSLAZ_RS07830	COG2835	tetraacyldisaccharide 4'-kinase activity
MSLAZ_RS07840	COG0504	CTP synthase activity
MSLAZ_RS07845	COG0585	pseudouridine synthase activity
MSLAZ_RS07865	COG0822	iron-sulfur transferase activity
MSLAZ_RS07875	COG2244	polysaccharide biosynthetic process
MSLAZ_RS07920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSLAZ_RS07920	COG4451	ribulose bisphosphate carboxylase, small
MSLAZ_RS08000	COG1136	(ABC) transporter
MSLAZ_RS08010	COG1136	(ABC) transporter
MSLAZ_RS08010	COG0577	efflux transmembrane transporter activity
MSLAZ_RS08030	COG2205	protein histidine kinase activity
MSLAZ_RS08030	COG2202	Pas domain
MSLAZ_RS08040	COG2205	protein histidine kinase activity
MSLAZ_RS08060	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSLAZ_RS08105	COG0058	SHG alpha-glucan phosphorylase activity
MSLAZ_RS08165	COG1061	Type III restriction enzyme res subunit
MSLAZ_RS08170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSLAZ_RS08190	COG0492	ferredoxin-NADP+ reductase activity
MSLAZ_RS08205	COG0668	transmembrane transport
MSLAZ_RS08245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSLAZ_RS08250	COG4467	Involved in initiation control of chromosome replication
MSLAZ_RS08255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSLAZ_RS08265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSLAZ_RS08345	COG1492	cobalamin metabolic process
MSLAZ_RS08380	COG1233	COG1233 Phytoene dehydrogenase and related
MSLAZ_RS08445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MSLAZ_RS08450	COG3830	Belongs to the UPF0237 family
MSLAZ_RS08455	COG2848	UPF0210 protein
MSLAZ_RS08460	COG1138	Cytochrome C-type biogenesis protein
MSLAZ_RS08475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSLAZ_RS08495	COG2814	Major facilitator Superfamily
MSLAZ_RS08540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSLAZ_RS08550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MSLAZ_RS08605	COG0730	response to heat
MSLAZ_RS08605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSLAZ_RS08610	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSLAZ_RS08690	COG0826	peptidase U32
MSLAZ_RS08700	COG0534	Mate efflux family protein
MSLAZ_RS08715	COG0306	phosphate transporter
MSLAZ_RS08760	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSLAZ_RS08765	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS08815	COG2326	polyphosphate kinase activity
MSLAZ_RS08820	COG0745	RESPONSE REGULATOR receiver
MSLAZ_RS08830	COG0745	RESPONSE REGULATOR receiver
MSLAZ_RS08865	COG5012	cobalamin binding
MSLAZ_RS08945	COG1280	lysine exporter protein (LysE YggA)
MSLAZ_RS08950	COG0596	Alpha beta hydrolase
MSLAZ_RS08955	COG2814	Major facilitator Superfamily
MSLAZ_RS09005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSLAZ_RS09010	COG0628	permease
MSLAZ_RS09035	COG0352	thiamine-phosphate diphosphorylase activity
MSLAZ_RS09050	COG2873	o-acetylhomoserine
MSLAZ_RS09055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MSLAZ_RS09140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSLAZ_RS09145	COG0392	lysyltransferase activity
MSLAZ_RS09145	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MSLAZ_RS09175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSLAZ_RS09210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSLAZ_RS09225	COG1053	succinate dehydrogenase
MSLAZ_RS09230	COG1053	succinate dehydrogenase
MSLAZ_RS09290	COG1295	ribonuclease BN
MSLAZ_RS09315	COG0501	Belongs to the peptidase M48B family
MSLAZ_RS09330	COG1131	(ABC) transporter
MSLAZ_RS09360	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSLAZ_RS09375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSLAZ_RS09480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSLAZ_RS09495	COG2271	Major facilitator Superfamily
MSLAZ_RS09500	COG1846	Transcriptional regulator
MSLAZ_RS09510	COG0134	indole-3-glycerol-phosphate synthase activity
MSLAZ_RS09515	COG0133	tryptophan synthase activity
MSLAZ_RS09520	COG0159	tryptophan synthase activity
MSLAZ_RS09525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSLAZ_RS09530	COG0135	phosphoribosylanthranilate isomerase activity
MSLAZ_RS09540	COG0512	Glutamine amidotransferase of anthranilate synthase
MSLAZ_RS09540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSLAZ_RS09570	COG3285	dna ligase
MSLAZ_RS09570	COG1793	dna ligase
MSLAZ_RS09625	COG1185	polyribonucleotide nucleotidyltransferase activity
MSLAZ_RS09630	COG1185	polyribonucleotide nucleotidyltransferase activity
MSLAZ_RS09660	COG2205	protein histidine kinase activity
MSLAZ_RS09660	COG2202	Pas domain
MSLAZ_RS09665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSLAZ_RS09695	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSLAZ_RS09710	COG2195	Cleaves the N-terminal amino acid of tripeptides
MSLAZ_RS09755	COG1254	Belongs to the acylphosphatase family
MSLAZ_RS09760	COG1230	cation diffusion facilitator family transporter
MSLAZ_RS09790	COG1201	RNA secondary structure unwinding
MSLAZ_RS09805	COG3339	Conserved Protein
MSLAZ_RS09820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSLAZ_RS09830	COG1618	nucleotide phosphatase activity, acting on free nucleotides
MSLAZ_RS09855	COG3264	Mechanosensitive ion channel
MSLAZ_RS09855	COG1196	nuclear chromosome segregation
MSLAZ_RS09865	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS09900	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MSLAZ_RS09910	COG2221	Nitrite and sulphite reductase 4Fe-4S
MSLAZ_RS09920	COG0778	Nitroreductase
MSLAZ_RS10000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MSLAZ_RS10040	COG0322	excinuclease ABC activity
MSLAZ_RS10045	COG0556	nucleotide-excision repair
MSLAZ_RS10070	COG0641	radical SAM
MSLAZ_RS10090	COG1836	PFAM Integral membrane protein DUF92
MSLAZ_RS10095	COG0151	Belongs to the GarS family
MSLAZ_RS10100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSLAZ_RS10135	COG1074	ATP-dependent DNA helicase activity
MSLAZ_RS10190	COG0753	catalase activity
MSLAZ_RS10195	COG1970	mechanosensitive ion channel activity
MSLAZ_RS10205	COG0708	Exodeoxyribonuclease III
MSLAZ_RS10220	COG1324	tolerance protein
MSLAZ_RS10230	COG1205	dead DEAH box helicase
MSLAZ_RS10230	COG1111	helicase
MSLAZ_RS10235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MSLAZ_RS10260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSLAZ_RS10270	COG1704	LemA family
MSLAZ_RS10350	COG0420	3'-5' exonuclease activity
MSLAZ_RS10355	COG4717	serine-type aminopeptidase activity
MSLAZ_RS10405	COG4467	Involved in initiation control of chromosome replication
MSLAZ_RS10410	COG0531	amino acid
MSLAZ_RS10430	COG2095	MarC family integral membrane protein
MSLAZ_RS10455	COG1741	Belongs to the pirin family
MSLAZ_RS10495	COG0367	asparagine synthase
MSLAZ_RS10510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSLAZ_RS10515	COG0047	phosphoribosylformylglycinamidine synthase activity
MSLAZ_RS10600	COG1309	transcriptional regulator
MSLAZ_RS10615	COG2205	protein histidine kinase activity
MSLAZ_RS10625	COG1073	alpha beta
MSLAZ_RS10680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MSLAZ_RS10690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSLAZ_RS10690	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSLAZ_RS10715	COG0426	domain, Protein
MSLAZ_RS10725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSLAZ_RS10750	COG0534	Mate efflux family protein
MSLAZ_RS10755	COG1846	Transcriptional regulator
MSLAZ_RS10780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSLAZ_RS10785	COG0530	calcium, potassium:sodium antiporter activity
MSLAZ_RS10800	COG0129	dihydroxy-acid dehydratase activity
MSLAZ_RS10815	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSLAZ_RS10830	COG2255	four-way junction helicase activity
MSLAZ_RS10850	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSLAZ_RS10855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS10865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MSLAZ_RS10875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSLAZ_RS10880	COG0436	Aminotransferase
MSLAZ_RS10885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSLAZ_RS10885	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MSLAZ_RS10890	COG2239	Acts as a magnesium transporter
MSLAZ_RS10895	COG0348	domain, Protein
MSLAZ_RS10925	COG2361	Protein of unknown function DUF86
MSLAZ_RS11020	COG0531	amino acid
MSLAZ_RS11155	COG0653	protein targeting
MSLAZ_RS11210	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MSLAZ_RS11240	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSLAZ_RS11245	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSLAZ_RS11245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSLAZ_RS11275	COG0589	response to stress
MSLAZ_RS11285	COG0312	modulator of DNA gyrase
MSLAZ_RS11295	COG1067	ATP-dependent peptidase activity
MSLAZ_RS11295	COG0470	DNA polymerase III
MSLAZ_RS11340	COG0028	Belongs to the TPP enzyme family
MSLAZ_RS11340	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MSLAZ_RS11405	COG0733	neurotransmitter:sodium symporter activity
MSLAZ_RS11435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSLAZ_RS11460	COG0459	protein refolding
MSLAZ_RS11470	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSLAZ_RS11475	COG0017	Asparaginyl-tRNA synthetase
MSLAZ_RS11500	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSLAZ_RS11505	COG1181	Belongs to the D-alanine--D-alanine ligase family
MSLAZ_RS11535	COG0424	maF-like protein
MSLAZ_RS11540	COG0215	cysteine-tRNA ligase activity
MSLAZ_RS11550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSLAZ_RS11575	COG0746	molybdenum cofactor guanylyltransferase activity
MSLAZ_RS11585	COG2003	Belongs to the UPF0758 family
MSLAZ_RS11625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSLAZ_RS11630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSLAZ_RS11645	COG0505	Belongs to the CarA family
MSLAZ_RS11650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSLAZ_RS11660	COG1301	dicarboxylic acid transport
MSLAZ_RS11685	COG0551	DNA topoisomerase type I activity
MSLAZ_RS11685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSLAZ_RS11715	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MSLAZ_RS11760	COG5310	Homospermidine synthase
MSLAZ_RS11835	COG5658	integral membrane protein
MSLAZ_RS11880	COG0473	3-isopropylmalate dehydrogenase activity
MSLAZ_RS11905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSLAZ_RS11915	COG3527	Alpha-acetolactate decarboxylase
MSLAZ_RS11920	COG0426	domain, Protein
MSLAZ_RS11945	COG2033	superoxide reductase activity
MSLAZ_RS11985	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSLAZ_RS11990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MSLAZ_RS12010	COG1331	Highly conserved protein containing a thioredoxin domain
MSLAZ_RS12020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSLAZ_RS12050	COG0318	PFAM AMP-dependent synthetase and ligase
MSLAZ_RS12060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSLAZ_RS12065	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSLAZ_RS12085	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSLAZ_RS12100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSLAZ_RS12105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSLAZ_RS12135	COG1185	polyribonucleotide nucleotidyltransferase activity
MSLAZ_RS12165	COG0371	Dehydrogenase
MSLAZ_RS12185	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS12215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MSLAZ_RS12265	COG1518	maintenance of DNA repeat elements
MSLAZ_RS12270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MSLAZ_RS12300	COG0531	amino acid
MSLAZ_RS12325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MSLAZ_RS12335	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSLAZ_RS12345	COG1797	cobyrinic acid a,c-diamide synthase activity
MSLAZ_RS12360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSLAZ_RS12365	COG0587	DNA-directed DNA polymerase activity
MSLAZ_RS12435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSLAZ_RS12440	COG0038	chloride channel
MSLAZ_RS12445	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSLAZ_RS12450	COG0280	phosphate acetyltransferase
MSLAZ_RS12455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSLAZ_RS12480	COG1573	uracil-dna glycosylase
MSLAZ_RS12485	COG0126	phosphoglycerate kinase activity
MSLAZ_RS12495	COG0071	Belongs to the small heat shock protein (HSP20) family
MSLAZ_RS12535	COG1136	(ABC) transporter
MSLAZ_RS12535	COG0577	efflux transmembrane transporter activity
MSLAZ_RS12565	COG0456	acetyltransferase
MSLAZ_RS12575	COG3613	nucleoside 2-deoxyribosyltransferase
MSLAZ_RS12585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSLAZ_RS12595	COG0517	IMP dehydrogenase activity
MSLAZ_RS12600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSLAZ_RS12680	COG0310	cobalt ion transport
MSLAZ_RS12685	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSLAZ_RS12695	COG1122	ATPase activity
MSLAZ_RS12720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSLAZ_RS12725	COG0561	phosphatase activity
MSLAZ_RS12775	COG1121	(ABC) transporter
MSLAZ_RS12780	COG4581	dead DEAH box helicase
MSLAZ_RS12785	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSLAZ_RS12790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MSLAZ_RS12795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MSLAZ_RS12820	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MSLAZ_RS12825	COG0352	thiamine-phosphate diphosphorylase activity
MSLAZ_RS12825	COG0351	phosphomethylpyrimidine kinase
MSLAZ_RS12835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSLAZ_RS12840	COG0432	Pfam Uncharacterised protein family UPF0047
MSLAZ_RS12870	COG0534	Mate efflux family protein
MSLAZ_RS12885	COG1846	Transcriptional regulator
MSLAZ_RS12940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSLAZ_RS12945	COG1733	regulation of RNA biosynthetic process
MSLAZ_RS12950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSLAZ_RS12985	COG0077	Prephenate dehydratase
MSLAZ_RS12985	COG1605	Chorismate mutase
MSLAZ_RS13000	COG0714	Associated with various cellular activities
MSLAZ_RS13020	COG1971	Probably functions as a manganese efflux pump
MSLAZ_RS13030	COG0066	3-isopropylmalate dehydratase activity
MSLAZ_RS13105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSLAZ_RS13110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MSLAZ_RS13140	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS13160	COG2226	methyltransferase
MSLAZ_RS13165	COG0640	Transcriptional regulator
MSLAZ_RS13180	COG0493	'glutamate synthase
MSLAZ_RS13190	COG0778	Nitroreductase
MSLAZ_RS13195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSLAZ_RS13200	COG0440	acetolactate synthase activity
MSLAZ_RS13205	COG0028	Belongs to the TPP enzyme family
MSLAZ_RS13210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSLAZ_RS13215	COG1363	Peptidase, m42
MSLAZ_RS13230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSLAZ_RS13255	COG5012	cobalamin binding
MSLAZ_RS13280	COG5012	cobalamin binding
MSLAZ_RS13295	COG1372	Participates in initiation and elongation during chromosome replication
MSLAZ_RS13295	COG0719	Fe-S assembly protein
MSLAZ_RS13300	COG0396	ATPase activity
MSLAZ_RS13305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSLAZ_RS13310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MSLAZ_RS13320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSLAZ_RS13325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSLAZ_RS13335	COG0124	histidyl-tRNA synthetase
MSLAZ_RS13345	COG1309	transcriptional regulator
MSLAZ_RS13350	COG1131	(ABC) transporter
MSLAZ_RS13400	COG1120	ATPase activity
MSLAZ_RS13405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSLAZ_RS13425	COG0157	Belongs to the NadC ModD family
MSLAZ_RS13435	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MSLAZ_RS13440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSLAZ_RS13455	COG0109	protoheme IX farnesyltransferase activity
MSLAZ_RS13460	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSLAZ_RS13465	COG1458	PINc domain ribonuclease
MSLAZ_RS13480	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSLAZ_RS13485	COG0284	orotidine-5'-phosphate decarboxylase activity
MSLAZ_RS13555	COG2314	TM2 domain
MSLAZ_RS13590	COG0668	transmembrane transport
MSLAZ_RS13645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSLAZ_RS13650	COG0088	Forms part of the polypeptide exit tunnel
MSLAZ_RS13655	COG0089	rRNA binding
MSLAZ_RS13665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSLAZ_RS13675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSLAZ_RS13680	COG0255	Belongs to the universal ribosomal protein uL29 family
MSLAZ_RS13695	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSLAZ_RS13700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MSLAZ_RS13720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSLAZ_RS13725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MSLAZ_RS13745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSLAZ_RS13765	COG0563	adenylate kinase activity
MSLAZ_RS13775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSLAZ_RS13780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSLAZ_RS13795	COG0316	Belongs to the HesB IscA family
MSLAZ_RS13835	COG1185	polyribonucleotide nucleotidyltransferase activity
MSLAZ_RS13845	COG0704	Plays a role in the regulation of phosphate uptake
MSLAZ_RS13850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSLAZ_RS13855	COG0581	inorganic phosphate transmembrane transporter activity
MSLAZ_RS13860	COG0573	inorganic phosphate transmembrane transporter activity
MSLAZ_RS13865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSLAZ_RS13870	COG1136	(ABC) transporter
MSLAZ_RS13875	COG0417	DNA replication proofreading
MSLAZ_RS13915	COG1122	ATPase activity
MSLAZ_RS13920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSLAZ_RS13950	COG2205	protein histidine kinase activity
MSLAZ_RS13975	COG5012	cobalamin binding
MSLAZ_RS13980	COG0145	ligase activity
MSLAZ_RS14000	COG5012	cobalamin binding
MSLAZ_RS14035	COG1131	(ABC) transporter
MSLAZ_RS14045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSLAZ_RS14050	COG0601	transmembrane transport
MSLAZ_RS14055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS14060	COG0747	negative chemotaxis
MSLAZ_RS14080	COG0243	molybdopterin cofactor binding
MSLAZ_RS14085	COG1229	Formylmethanofuran dehydrogenase subunit A
MSLAZ_RS14150	COG0039	L-malate dehydrogenase activity
MSLAZ_RS14165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSLAZ_RS14180	COG4095	Psort location CytoplasmicMembrane, score
MSLAZ_RS14185	COG0537	adenosine 5'-monophosphoramidase activity
MSLAZ_RS14190	COG0425	Belongs to the sulfur carrier protein TusA family
MSLAZ_RS14195	COG2210	Belongs to the sulfur carrier protein TusA family
MSLAZ_RS14200	COG1104	cysteine desulfurase activity
MSLAZ_RS14205	COG0822	iron-sulfur transferase activity
MSLAZ_RS14235	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS14305	COG1012	belongs to the aldehyde dehydrogenase family
MSLAZ_RS14320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSLAZ_RS14325	COG0475	glutathione-regulated potassium exporter activity
MSLAZ_RS14330	COG0516	GMP reductase activity
MSLAZ_RS14330	COG0517	IMP dehydrogenase activity
MSLAZ_RS14355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSLAZ_RS14360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSLAZ_RS14375	COG0517	IMP dehydrogenase activity
MSLAZ_RS14380	COG0589	response to stress
MSLAZ_RS14385	COG0402	S-adenosylhomocysteine deaminase activity
MSLAZ_RS14410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSLAZ_RS14415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSLAZ_RS14420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MSLAZ_RS14425	COG0450	alkyl hydroperoxide reductase
MSLAZ_RS14435	COG0347	Belongs to the P(II) protein family
MSLAZ_RS14440	COG0004	ammonium transporteR
MSLAZ_RS14485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSLAZ_RS14495	COG0602	queuosine metabolic process
MSLAZ_RS14500	COG0720	synthase
MSLAZ_RS14505	COG0535	radical SAM domain protein
MSLAZ_RS14505	COG1433	Dinitrogenase iron-molybdenum cofactor
MSLAZ_RS14510	COG1433	Dinitrogenase iron-molybdenum cofactor
MSLAZ_RS14510	COG0535	radical SAM domain protein
MSLAZ_RS14520	COG2144	transferase activity, transferring acyl groups
MSLAZ_RS14580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSLAZ_RS14585	COG5012	cobalamin binding
MSLAZ_RS14610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MSLAZ_RS14620	COG1394	ATPase activity, coupled to movement of substances
MSLAZ_RS14625	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MSLAZ_RS14655	COG1269	ATP hydrolysis coupled proton transport
MSLAZ_RS14665	COG0535	radical SAM domain protein
MSLAZ_RS14670	COG0142	geranyltranstransferase activity
MSLAZ_RS14690	COG0671	phosphoesterase, PA-phosphatase related
MSLAZ_RS14720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSLAZ_RS14740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSLAZ_RS14785	COG0552	protein localization to endoplasmic reticulum
MSLAZ_RS14790	COG1983	PspC domain protein
MSLAZ_RS14815	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MSLAZ_RS14825	COG0067	glutamate synthase
MSLAZ_RS14895	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MSLAZ_RS14905	COG0024	Methionine aminopeptidase
MSLAZ_RS14935	COG2048	Heterodisulfide reductase, subunit B
MSLAZ_RS14960	COG0489	protein tyrosine kinase activity
MSLAZ_RS14975	COG1342	Belongs to the UPF0251 family
MSLAZ_RS14980	COG0489	protein tyrosine kinase activity
MSLAZ_RS15030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSLAZ_RS15035	COG0473	3-isopropylmalate dehydrogenase activity
MSLAZ_RS15070	COG1628	Protein of unknown function DUF99
MSLAZ_RS15075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSLAZ_RS15090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSLAZ_RS15095	COG0081	regulation of translation
MSLAZ_RS15100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSLAZ_RS15110	COG1598	PFAM Uncharacterised protein family UPF0150
MSLAZ_RS15170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MSLAZ_RS15185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSLAZ_RS15200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSLAZ_RS15205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MSLAZ_RS15210	COG1196	nuclear chromosome segregation
MSLAZ_RS15225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSLAZ_RS15225	COG1918	ferrous iron import across plasma membrane
MSLAZ_RS15235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSLAZ_RS15245	COG1268	BioY protein
MSLAZ_RS15250	COG1122	ATPase activity
MSLAZ_RS15255	COG1122	ATPase activity
MSLAZ_RS15260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSLAZ_RS15270	COG0640	Transcriptional regulator
MSLAZ_RS15300	COG0303	'Molybdopterin
MSLAZ_RS15305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSLAZ_RS15315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MSLAZ_RS15330	COG1254	Belongs to the acylphosphatase family
MSLAZ_RS15415	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS15435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSLAZ_RS15465	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MSLAZ_RS15470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSLAZ_RS15495	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS15510	COG0297	glycogen (starch) synthase activity
MSLAZ_RS15515	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS15530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSLAZ_RS15535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MSLAZ_RS15560	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS15590	COG1215	transferase activity, transferring glycosyl groups
MSLAZ_RS15645	COG1891	lyase activity
MSLAZ_RS15660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSLAZ_RS15680	COG0560	Phosphoserine phosphatase
MSLAZ_RS15680	COG3830	Belongs to the UPF0237 family
MSLAZ_RS15700	COG0109	protoheme IX farnesyltransferase activity
MSLAZ_RS15705	COG0343	queuine tRNA-ribosyltransferase activity
MSLAZ_RS15735	COG0459	protein refolding
MSLAZ_RS15745	COG0247	lactate metabolic process
MSLAZ_RS15745	COG2181	nitrate reductase activity
MSLAZ_RS15760	COG1372	Participates in initiation and elongation during chromosome replication
MSLAZ_RS15760	COG0719	Fe-S assembly protein
MSLAZ_RS15765	COG0396	ATPase activity
MSLAZ_RS15770	COG1234	tRNA 3'-trailer cleavage
MSLAZ_RS15790	COG0012	GTP binding
MSLAZ_RS15830	COG1584	GPR1 FUN34 yaaH family protein
MSLAZ_RS15840	COG5012	cobalamin binding
MSLAZ_RS15845	COG0523	cobalamin synthesis protein
MSLAZ_RS15870	COG5012	cobalamin binding
MSLAZ_RS15890	COG0523	cobalamin synthesis protein
MSLAZ_RS15900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSLAZ_RS15905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSLAZ_RS15910	COG2202	Pas domain
MSLAZ_RS15910	COG2205	protein histidine kinase activity
MSLAZ_RS15915	COG0784	Response regulator, receiver
MSLAZ_RS15935	COG3261	NADH dehydrogenase
MSLAZ_RS15935	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MSLAZ_RS15940	COG0651	ATP synthesis coupled electron transport
MSLAZ_RS15955	COG0651	ATP synthesis coupled electron transport
MSLAZ_RS15970	COG4152	abc transporter atp-binding protein
MSLAZ_RS16065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MSLAZ_RS16070	COG2226	methyltransferase
MSLAZ_RS16075	COG2244	polysaccharide biosynthetic process
MSLAZ_RS16080	COG2244	polysaccharide biosynthetic process
MSLAZ_RS16085	COG0367	asparagine synthase
MSLAZ_RS16105	COG0110	maltose O-acetyltransferase activity
MSLAZ_RS16125	COG0297	glycogen (starch) synthase activity
MSLAZ_RS16165	COG2244	polysaccharide biosynthetic process
MSLAZ_RS16180	COG1216	Glycosyl transferase, family 2
MSLAZ_RS16180	COG1442	glycosyl transferase family 8
MSLAZ_RS16190	COG0297	glycogen (starch) synthase activity
MSLAZ_RS16190	COG0438	transferase activity, transferring glycosyl groups
MSLAZ_RS16285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSLAZ_RS16290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSLAZ_RS16350	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MSLAZ_RS16355	COG0540	Belongs to the ATCase OTCase family
MSLAZ_RS16390	COG0514	ATP-dependent DNA helicase (RecQ)
MSLAZ_RS16405	COG0066	3-isopropylmalate dehydratase activity
MSLAZ_RS16410	COG0473	3-isopropylmalate dehydrogenase activity
MSLAZ_RS16430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS16455	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSLAZ_RS16470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS16475	COG0535	radical SAM domain protein
MSLAZ_RS16490	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSLAZ_RS16570	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSLAZ_RS16575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSLAZ_RS16580	COG2198	Histidine kinase
MSLAZ_RS16580	COG0643	Histidine kinase
MSLAZ_RS16585	COG2201	protein-glutamate methylesterase activity
MSLAZ_RS16590	COG2201	protein-glutamate methylesterase activity
MSLAZ_RS16605	COG0784	Response regulator, receiver
MSLAZ_RS16610	COG0840	transmembrane signaling receptor activity
MSLAZ_RS16635	COG1121	(ABC) transporter
MSLAZ_RS16640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MSLAZ_RS16670	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSLAZ_RS16675	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSLAZ_RS16720	COG0018	arginyl-trna synthetase
MSLAZ_RS16755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS16760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS16765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS16770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSLAZ_RS16785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSLAZ_RS16790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MSLAZ_RS16805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSLAZ_RS16835	COG1260	myo-inositol-1-phosphate synthase
MSLAZ_RS16840	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSLAZ_RS16855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSLAZ_RS16865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MSLAZ_RS16885	COG0459	protein refolding
MSLAZ_RS16895	COG0443	Heat shock 70 kDa protein
MSLAZ_RS16900	COG0484	heat shock protein binding
MSLAZ_RS16910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSLAZ_RS16950	COG0423	glycine-tRNA ligase activity
MSLAZ_RS16970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSLAZ_RS17015	COG0688	phosphatidylethanolamine metabolic process
MSLAZ_RS17020	COG1183	phosphatidylcholine synthase activity
MSLAZ_RS17030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSLAZ_RS17035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSLAZ_RS17090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSLAZ_RS17100	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSLAZ_RS17120	COG0778	Nitroreductase
MSLAZ_RS17120	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MSLAZ_RS17135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSLAZ_RS17140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSLAZ_RS17160	COG0531	amino acid
MSLAZ_RS17175	COG5012	cobalamin binding
MSLAZ_RS17190	COG5012	cobalamin binding
MSLAZ_RS17195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSLAZ_RS17215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MSLAZ_RS17220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSLAZ_RS17230	COG1342	Belongs to the UPF0251 family
MSLAZ_RS17250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSLAZ_RS17250	COG0731	radical SAM domain protein
MSLAZ_RS17270	COG0076	glutamate decarboxylase activity
MSLAZ_RS17640	COG0110	maltose O-acetyltransferase activity
MSLAZ_RS17660	COG0463	Glycosyl transferase, family 2
MSLAZ_RS17675	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MSLAZ_RS17880	COG1401	restriction endodeoxyribonuclease activity
MSLAZ_RS17915	COG0697	spore germination
MSLAZ_RS18080	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSLAZ_RS18195	COG1598	PFAM Uncharacterised protein family UPF0150
MSLAZ_RS18310	COG2205	protein histidine kinase activity
MSLAZ_RS18310	COG2202	Pas domain