locus-tag	class	description
MM_RS00015	COG0601	transmembrane transport
MM_RS00020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM_RS00025	COG0444	Belongs to the ABC transporter superfamily
MM_RS00065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MM_RS00070	COG2226	methyltransferase
MM_RS00090	COG2226	methyltransferase
MM_RS00120	COG1598	PFAM Uncharacterised protein family UPF0150
MM_RS00155	COG0210	DNA helicase
MM_RS00170	COG1598	PFAM Uncharacterised protein family UPF0150
MM_RS00200	COG0137	argininosuccinate synthase activity
MM_RS00205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MM_RS00210	COG0505	Belongs to the CarA family
MM_RS00215	COG0517	IMP dehydrogenase activity
MM_RS00215	COG4175	Glycine betaine
MM_RS00255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MM_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
MM_RS00270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MM_RS00285	COG0589	response to stress
MM_RS00295	COG1233	COG1233 Phytoene dehydrogenase and related
MM_RS00360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MM_RS00370	COG0459	protein refolding
MM_RS00375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MM_RS00380	COG0017	Asparaginyl-tRNA synthetase
MM_RS00395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MM_RS00400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MM_RS00415	COG2848	UPF0210 protein
MM_RS00420	COG3830	Belongs to the UPF0237 family
MM_RS00460	COG4591	ABC-type transport system involved in lipoprotein release permease component
MM_RS00470	COG1492	cobalamin metabolic process
MM_RS00530	COG1346	cytolysis
MM_RS00545	COG0822	iron-sulfur transferase activity
MM_RS00570	COG0585	pseudouridine synthase activity
MM_RS00575	COG0534	Mate efflux family protein
MM_RS00600	COG0504	CTP synthase activity
MM_RS00620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM_RS00635	COG0589	response to stress
MM_RS00640	COG0312	modulator of DNA gyrase
MM_RS00645	COG0312	modulator of DNA gyrase
MM_RS00650	COG0470	DNA polymerase III
MM_RS00650	COG1067	ATP-dependent peptidase activity
MM_RS00695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM_RS00745	COG1138	Cytochrome C-type biogenesis protein
MM_RS00760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MM_RS00770	COG0151	Belongs to the GarS family
MM_RS00775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MM_RS00800	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MM_RS00900	COG5310	Homospermidine synthase
MM_RS00915	COG3920	Histidine kinase
MM_RS00930	COG0784	Response regulator, receiver
MM_RS00930	COG4191	Histidine kinase
MM_RS00935	COG0596	Alpha beta hydrolase
MM_RS00970	COG5012	cobalamin binding
MM_RS00985	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MM_RS01015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MM_RS01020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
MM_RS01045	COG2361	Protein of unknown function DUF86
MM_RS01110	COG1598	PFAM Uncharacterised protein family UPF0150
MM_RS01230	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MM_RS01285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MM_RS01300	COG0668	transmembrane transport
MM_RS01325	COG0517	IMP dehydrogenase activity
MM_RS01325	COG0516	GMP reductase activity
MM_RS01335	COG0436	Aminotransferase
MM_RS01340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MM_RS01350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MM_RS01355	COG0617	tRNA 3'-terminal CCA addition
MM_RS01355	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MM_RS01355	COG0517	IMP dehydrogenase activity
MM_RS01360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS01365	COG0655	NAD(P)H dehydrogenase (quinone) activity
MM_RS01415	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MM_RS01430	COG0129	dihydroxy-acid dehydratase activity
MM_RS01440	COG0426	domain, Protein
MM_RS01445	COG0653	protein targeting
MM_RS01550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MM_RS01555	COG0495	leucyl-tRNA aminoacylation
MM_RS01560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM_RS01570	COG1945	arginine decarboxylase activity
MM_RS01620	COG1174	glycine betaine transport
MM_RS01625	COG1125	glycine betaine transport
MM_RS01625	COG0517	IMP dehydrogenase activity
MM_RS01635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MM_RS01640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MM_RS01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MM_RS01650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MM_RS01665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS01675	COG1234	tRNA 3'-trailer cleavage
MM_RS01690	COG0535	radical SAM domain protein
MM_RS01780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MM_RS01785	COG1776	CheC inhibitor of MCP methylation
MM_RS01790	COG0643	Histidine kinase
MM_RS01790	COG0643	Histidine kinase
MM_RS01790	COG2198	Histidine kinase
MM_RS01790	COG2198	Histidine kinase
MM_RS01795	COG2201	protein-glutamate methylesterase activity
MM_RS01800	COG2201	protein-glutamate methylesterase activity
MM_RS01810	COG0835	chemotaxis
MM_RS01815	COG0840	transmembrane signaling receptor activity
MM_RS01835	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MM_RS01840	COG0351	phosphomethylpyrimidine kinase
MM_RS01855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MM_RS01860	COG0432	Pfam Uncharacterised protein family UPF0047
MM_RS01870	COG0534	Mate efflux family protein
MM_RS01880	COG1846	Transcriptional regulator
MM_RS01900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MM_RS01935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MM_RS01940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM_RS01940	COG1042	CoA-binding domain protein
MM_RS01940	COG0045	succinate-CoA ligase (ADP-forming) activity
MM_RS01950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM_RS01955	COG1733	regulation of RNA biosynthetic process
MM_RS01960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM_RS02000	COG1605	Chorismate mutase
MM_RS02000	COG0077	Prephenate dehydratase
MM_RS02010	COG0714	Associated with various cellular activities
MM_RS02050	COG1047	Peptidyl-prolyl cis-trans
MM_RS02065	COG5658	integral membrane protein
MM_RS02100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MM_RS02260	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM_RS02265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM_RS02265	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM_RS02285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MM_RS02290	COG4581	dead DEAH box helicase
MM_RS02295	COG1121	(ABC) transporter
MM_RS02310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM_RS02315	COG0732	type I restriction modification DNA specificity domain
MM_RS02320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MM_RS02345	COG3118	belongs to the thioredoxin family
MM_RS02365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MM_RS02370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MM_RS02375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MM_RS02380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MM_RS02400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS02410	COG0500	methyltransferase
MM_RS02415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MM_RS02445	COG0561	phosphatase activity
MM_RS02455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MM_RS02475	COG1122	ATPase activity
MM_RS02485	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MM_RS02490	COG0310	cobalt ion transport
MM_RS02540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MM_RS02545	COG0517	IMP dehydrogenase activity
MM_RS02550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MM_RS02560	COG3613	nucleoside 2-deoxyribosyltransferase
MM_RS02565	COG0456	acetyltransferase
MM_RS02575	COG0071	Belongs to the small heat shock protein (HSP20) family
MM_RS02580	COG2078	PFAM AMMECR1 domain protein
MM_RS02585	COG0126	phosphoglycerate kinase activity
MM_RS02590	COG1573	uracil-dna glycosylase
MM_RS02625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM_RS02625	COG1042	CoA-binding domain protein
MM_RS02625	COG0045	succinate-CoA ligase (ADP-forming) activity
MM_RS02630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MM_RS02635	COG0280	phosphate acetyltransferase
MM_RS02640	COG0655	NAD(P)H dehydrogenase (quinone) activity
MM_RS02645	COG0038	chloride channel
MM_RS02680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MM_RS02705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MM_RS02725	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MM_RS02745	COG4191	Histidine kinase
MM_RS02800	COG0531	amino acid
MM_RS02840	COG0662	Cupin 2, conserved barrel domain protein
MM_RS02850	COG1408	metallophosphoesterase
MM_RS02880	COG0557	exoribonuclease II activity
MM_RS02930	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MM_RS02935	COG1518	maintenance of DNA repeat elements
MM_RS02975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MM_RS02990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MM_RS02995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MM_RS03000	COG1785	Belongs to the alkaline phosphatase family
MM_RS03005	COG3431	PFAM Phosphate-starvation-inducible E
MM_RS03010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MM_RS03020	COG0704	Plays a role in the regulation of phosphate uptake
MM_RS03025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MM_RS03025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MM_RS03075	COG0438	transferase activity, transferring glycosyl groups
MM_RS03090	COG0371	Dehydrogenase
MM_RS03120	COG1185	polyribonucleotide nucleotidyltransferase activity
MM_RS03150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MM_RS03155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MM_RS03170	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MM_RS03195	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM_RS03200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MM_RS03210	COG0318	PFAM AMP-dependent synthetase and ligase
MM_RS03230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MM_RS03235	COG1331	Highly conserved protein containing a thioredoxin domain
MM_RS03275	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MM_RS03305	COG2033	superoxide reductase activity
MM_RS03315	COG0431	NADPH-dependent FMN reductase
MM_RS03335	COG0426	domain, Protein
MM_RS03340	COG3527	Alpha-acetolactate decarboxylase
MM_RS03355	COG0473	3-isopropylmalate dehydrogenase activity
MM_RS03370	COG0066	3-isopropylmalate dehydratase activity
MM_RS03390	COG0438	transferase activity, transferring glycosyl groups
MM_RS03405	COG1216	Glycosyl transferase, family 2
MM_RS03405	COG0463	Glycosyl transferase, family 2
MM_RS03430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MM_RS03435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MM_RS03445	COG2226	methyltransferase
MM_RS03450	COG0640	Transcriptional regulator
MM_RS03460	COG0493	'glutamate synthase
MM_RS03475	COG0864	Transcriptional regulator
MM_RS03480	COG0778	Nitroreductase
MM_RS03485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MM_RS03490	COG0440	acetolactate synthase activity
MM_RS03495	COG0028	Belongs to the TPP enzyme family
MM_RS03500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM_RS03510	COG1363	Peptidase, m42
MM_RS03525	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MM_RS03625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MM_RS03630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MM_RS03635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MM_RS03655	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MM_RS03660	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MM_RS03695	COG0442	prolyl-tRNA aminoacylation
MM_RS03700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MM_RS03760	COG0644	oxidoreductase
MM_RS03765	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MM_RS03775	COG0347	Belongs to the P(II) protein family
MM_RS03795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MM_RS03800	COG0725	ABC transporter, periplasmic molybdate-binding protein
MM_RS03805	COG4149	molybdate abc transporter
MM_RS03810	COG3842	ATPase activity
MM_RS03820	COG2226	methyltransferase
MM_RS03825	COG0347	Belongs to the P(II) protein family
MM_RS03830	COG0004	ammonium transporteR
MM_RS03840	COG1742	UPF0060 membrane protein
MM_RS03880	COG0798	PFAM Bile acid sodium symporter
MM_RS03905	COG0513	Belongs to the DEAD box helicase family
MM_RS03910	COG2226	methyltransferase
MM_RS03915	COG1063	alcohol dehydrogenase
MM_RS03935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MM_RS03945	COG0602	queuosine metabolic process
MM_RS03950	COG0720	synthase
MM_RS03955	COG0535	radical SAM domain protein
MM_RS03955	COG1433	Dinitrogenase iron-molybdenum cofactor
MM_RS03965	COG1433	Dinitrogenase iron-molybdenum cofactor
MM_RS03965	COG0535	radical SAM domain protein
MM_RS03975	COG2144	transferase activity, transferring acyl groups
MM_RS04040	COG4572	Cation transport regulator
MM_RS04075	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MM_RS04080	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MM_RS04105	COG1269	ATP hydrolysis coupled proton transport
MM_RS04185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS04245	COG0552	protein localization to endoplasmic reticulum
MM_RS04250	COG1983	PspC domain protein
MM_RS04265	COG0450	alkyl hydroperoxide reductase
MM_RS04280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MM_RS04285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MM_RS04290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MM_RS04310	COG0402	S-adenosylhomocysteine deaminase activity
MM_RS04320	COG0517	IMP dehydrogenase activity
MM_RS04335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MM_RS04340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MM_RS04345	COG0303	'Molybdopterin
MM_RS04370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MM_RS04395	COG1216	Glycosyl transferase, family 2
MM_RS04400	COG0640	Transcriptional regulator
MM_RS04405	COG0864	Transcriptional regulator
MM_RS04440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MM_RS04445	COG2155	Conserved Protein
MM_RS04460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MM_RS04460	COG0321	lipoyl(octanoyl) transferase activity
MM_RS04465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS04470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MM_RS04520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MM_RS04525	COG0616	signal peptide processing
MM_RS04530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MM_RS04530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MM_RS04545	COG0183	Belongs to the thiolase family
MM_RS04550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MM_RS04620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MM_RS04625	COG1122	ATPase activity
MM_RS04630	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MM_RS04650	COG2226	methyltransferase
MM_RS04655	COG0310	cobalt ion transport
MM_RS04665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MM_RS04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MM_RS04675	COG0138	bifunctional purine biosynthesis protein purh
MM_RS04695	COG0500	methyltransferase
MM_RS04700	COG1584	GPR1 FUN34 yaaH family protein
MM_RS04710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MM_RS04720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MM_RS04740	COG2217	Heavy metal translocating P-type atpase
MM_RS04745	COG1122	ATPase activity
MM_RS04785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MM_RS04785	COG5549	protein import
MM_RS04790	COG0494	nUDIX hydrolase
MM_RS04805	COG0010	Belongs to the arginase family
MM_RS04825	COG1476	TRANSCRIPTIONal
MM_RS04855	COG4651	solute:proton antiporter activity
MM_RS04855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MM_RS04860	COG1509	lysine 2,3-aminomutase activity
MM_RS04865	COG0456	acetyltransferase
MM_RS04880	COG4962	Type ii secretion system protein e
MM_RS04885	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MM_RS04905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MM_RS04915	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MM_RS04920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MM_RS04935	COG0577	efflux transmembrane transporter activity
MM_RS04940	COG2205	protein histidine kinase activity
MM_RS04950	COG1136	(ABC) transporter
MM_RS04955	COG0577	efflux transmembrane transporter activity
MM_RS04965	COG1136	(ABC) transporter
MM_RS04990	COG0004	ammonium transporteR
MM_RS04995	COG0347	Belongs to the P(II) protein family
MM_RS05020	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MM_RS05035	COG0067	glutamate synthase
MM_RS05075	COG0024	Methionine aminopeptidase
MM_RS05105	COG2048	Heterodisulfide reductase, subunit B
MM_RS05135	COG0489	protein tyrosine kinase activity
MM_RS05150	COG1342	Belongs to the UPF0251 family
MM_RS05155	COG0489	protein tyrosine kinase activity
MM_RS05210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM_RS05215	COG0473	3-isopropylmalate dehydrogenase activity
MM_RS05230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS05245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MM_RS05260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MM_RS05265	COG0081	regulation of translation
MM_RS05270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MM_RS05280	COG0535	radical SAM domain protein
MM_RS05330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MM_RS05350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MM_RS05360	COG1196	nuclear chromosome segregation
MM_RS05375	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MM_RS05375	COG1918	ferrous iron import across plasma membrane
MM_RS05385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MM_RS05395	COG1268	BioY protein
MM_RS05400	COG1122	ATPase activity
MM_RS05405	COG1122	ATPase activity
MM_RS05410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MM_RS05415	COG0640	Transcriptional regulator
MM_RS05450	COG0303	'Molybdopterin
MM_RS05455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MM_RS05465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MM_RS05505	COG5012	cobalamin binding
MM_RS05515	COG4152	abc transporter atp-binding protein
MM_RS05525	COG0651	ATP synthesis coupled electron transport
MM_RS05540	COG0651	ATP synthesis coupled electron transport
MM_RS05545	COG3261	NADH dehydrogenase
MM_RS05545	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MM_RS05565	COG0784	Response regulator, receiver
MM_RS05570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MM_RS05585	COG0523	cobalamin synthesis protein
MM_RS05595	COG5012	cobalamin binding
MM_RS05605	COG1584	GPR1 FUN34 yaaH family protein
MM_RS05645	COG0012	GTP binding
MM_RS05670	COG0396	ATPase activity
MM_RS05675	COG1372	Participates in initiation and elongation during chromosome replication
MM_RS05675	COG0719	Fe-S assembly protein
MM_RS05685	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MM_RS05690	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MM_RS05695	COG4251	negative regulation of phosphorylation
MM_RS05700	COG4251	negative regulation of phosphorylation
MM_RS05720	COG0459	protein refolding
MM_RS05740	COG0343	queuine tRNA-ribosyltransferase activity
MM_RS05745	COG0109	protoheme IX farnesyltransferase activity
MM_RS05765	COG3830	Belongs to the UPF0237 family
MM_RS05765	COG0560	Phosphoserine phosphatase
MM_RS05785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MM_RS05795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MM_RS05800	COG1891	lyase activity
MM_RS05835	COG1442	glycosyl transferase family 8
MM_RS05835	COG1216	Glycosyl transferase, family 2
MM_RS05860	COG0438	transferase activity, transferring glycosyl groups
MM_RS05865	COG0463	Glycosyl transferase, family 2
MM_RS05890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MM_RS05895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MM_RS05900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MM_RS05915	COG0438	transferase activity, transferring glycosyl groups
MM_RS05920	COG0438	transferase activity, transferring glycosyl groups
MM_RS05925	COG0463	Glycosyl transferase, family 2
MM_RS05925	COG1216	Glycosyl transferase, family 2
MM_RS05935	COG1216	Glycosyl transferase, family 2
MM_RS05940	COG0297	glycogen (starch) synthase activity
MM_RS05945	COG0438	transferase activity, transferring glycosyl groups
MM_RS05990	COG0673	inositol 2-dehydrogenase activity
MM_RS06020	COG1254	Belongs to the acylphosphatase family
MM_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MM_RS06045	COG2361	Protein of unknown function DUF86
MM_RS06050	COG0463	Glycosyl transferase, family 2
MM_RS06065	COG1091	dTDP-4-dehydrorhamnose reductase activity
MM_RS06130	COG0297	glycogen (starch) synthase activity
MM_RS06140	COG0463	Glycosyl transferase, family 2
MM_RS06220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MM_RS06225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MM_RS06275	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MM_RS06280	COG0540	Belongs to the ATCase OTCase family
MM_RS06300	COG0514	ATP-dependent DNA helicase (RecQ)
MM_RS06305	COG0519	Catalyzes the synthesis of GMP from XMP
MM_RS06305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MM_RS06315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MM_RS06325	COG1469	GTP cyclohydrolase I activity
MM_RS06340	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MM_RS06345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MM_RS06350	COG0154	amidase activity
MM_RS06355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MM_RS06360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MM_RS06365	COG2264	protein methyltransferase activity
MM_RS06380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MM_RS06385	COG1715	Restriction endonuclease
MM_RS06395	COG0501	Belongs to the peptidase M48B family
MM_RS06400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MM_RS06405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MM_RS06455	COG0009	L-threonylcarbamoyladenylate synthase
MM_RS06460	COG1850	ribulose-bisphosphate carboxylase activity
MM_RS06495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MM_RS06555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MM_RS06570	COG0519	Catalyzes the synthesis of GMP from XMP
MM_RS06570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MM_RS06575	COG1830	Aldolase
MM_RS06580	COG1465	3-dehydroquinate synthase
MM_RS06585	COG0710	3-dehydroquinate dehydratase activity
MM_RS06590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MM_RS06595	COG1605	Chorismate mutase
MM_RS06595	COG0287	Prephenate dehydrogenase
MM_RS06605	COG2890	protein-(glutamine-N5) methyltransferase activity
MM_RS06610	COG2022	thiamine diphosphate biosynthetic process
MM_RS06615	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MM_RS06620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MM_RS06665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM_RS06675	COG0084	hydrolase, TatD family'
MM_RS06700	COG0247	lactate metabolic process
MM_RS06705	COG0277	FAD linked oxidase domain protein
MM_RS06715	COG0456	acetyltransferase
MM_RS06735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM_RS06740	COG0430	RNA-3'-phosphate cyclase activity
MM_RS06775	COG0516	GMP reductase activity
MM_RS06780	COG0516	GMP reductase activity
MM_RS06780	COG0517	IMP dehydrogenase activity
MM_RS06835	COG0076	glutamate decarboxylase activity
MM_RS06855	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MM_RS06860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MM_RS06870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MM_RS06875	COG2198	Histidine kinase
MM_RS06875	COG0643	Histidine kinase
MM_RS06880	COG2201	protein-glutamate methylesterase activity
MM_RS06885	COG2201	protein-glutamate methylesterase activity
MM_RS06890	COG0784	Response regulator, receiver
MM_RS06895	COG0840	transmembrane signaling receptor activity
MM_RS06905	COG2610	gluconate transmembrane transporter activity
MM_RS06920	COG1121	(ABC) transporter
MM_RS06925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MM_RS06945	COG1013	pyruvate-flavodoxin oxidoreductase activity
MM_RS06950	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM_RS06990	COG0018	arginyl-trna synthetase
MM_RS07005	COG0482	sulfurtransferase activity
MM_RS07030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS07035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS07040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS07045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS07060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MM_RS07080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MM_RS07085	COG0602	queuosine metabolic process
MM_RS07105	COG1260	myo-inositol-1-phosphate synthase
MM_RS07110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MM_RS07125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MM_RS07130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MM_RS07150	COG0459	protein refolding
MM_RS07155	COG0443	Heat shock 70 kDa protein
MM_RS07170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MM_RS07190	COG0322	excinuclease ABC activity
MM_RS07195	COG0423	glycine-tRNA ligase activity
MM_RS07210	COG1584	GPR1 FUN34 yaaH family protein
MM_RS07215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MM_RS07220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MM_RS07260	COG0688	phosphatidylethanolamine metabolic process
MM_RS07265	COG1183	phosphatidylcholine synthase activity
MM_RS07275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MM_RS07280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MM_RS07330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MM_RS07340	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MM_RS07345	COG0071	Belongs to the small heat shock protein (HSP20) family
MM_RS07355	COG0778	Nitroreductase
MM_RS07355	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MM_RS07370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MM_RS07375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MM_RS07415	COG0531	amino acid
MM_RS07430	COG5012	cobalamin binding
MM_RS07435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MM_RS07445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MM_RS07460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MM_RS07465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MM_RS07480	COG1342	Belongs to the UPF0251 family
MM_RS07490	COG0731	radical SAM domain protein
MM_RS07490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MM_RS07520	COG0589	response to stress
MM_RS07525	COG0589	response to stress
MM_RS07550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MM_RS07590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MM_RS07615	COG0535	radical SAM domain protein
MM_RS07620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS07635	COG0521	Mo-molybdopterin cofactor biosynthetic process
MM_RS07640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MM_RS07645	COG4279	zinc finger
MM_RS07675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS07685	COG0473	3-isopropylmalate dehydrogenase activity
MM_RS07690	COG0066	3-isopropylmalate dehydratase activity
MM_RS07715	COG0101	tRNA pseudouridine synthase activity
MM_RS07735	COG0024	Methionine aminopeptidase
MM_RS07760	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MM_RS07765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MM_RS07770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MM_RS07775	COG0131	Imidazoleglycerol-phosphate dehydratase
MM_RS07835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MM_RS07850	COG1247	-acetyltransferase
MM_RS07855	COG1606	tRNA processing
MM_RS07860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MM_RS07865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM_RS07890	COG0372	Belongs to the citrate synthase family
MM_RS07895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MM_RS07905	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MM_RS07910	COG0714	Associated with various cellular activities
MM_RS07915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MM_RS07930	COG0235	Class ii aldolase
MM_RS07935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MM_RS07955	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MM_RS08000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MM_RS08065	COG4662	Binding-protein-dependent transport system inner membrane component
MM_RS08070	COG3842	ATPase activity
MM_RS08085	COG1229	Formylmethanofuran dehydrogenase subunit A
MM_RS08100	COG0243	molybdopterin cofactor binding
MM_RS08150	COG3842	ATPase activity
MM_RS08160	COG0725	ABC transporter, periplasmic molybdate-binding protein
MM_RS08165	COG2249	NAD(P)H dehydrogenase (quinone) activity
MM_RS08190	COG1733	regulation of RNA biosynthetic process
MM_RS08260	COG0428	transporter
MM_RS08305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MM_RS08310	COG0456	acetyltransferase
MM_RS08315	COG1136	(ABC) transporter
MM_RS08320	COG1136	(ABC) transporter
MM_RS08320	COG0577	efflux transmembrane transporter activity
MM_RS08330	COG0528	UMP kinase activity
MM_RS08355	COG1691	(AIR) carboxylase
MM_RS08360	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MM_RS08385	COG0523	cobalamin synthesis protein
MM_RS08415	COG1830	Aldolase
MM_RS08440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MM_RS08455	COG0577	efflux transmembrane transporter activity
MM_RS08475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MM_RS08490	COG0110	maltose O-acetyltransferase activity
MM_RS08535	COG5012	cobalamin binding
MM_RS08570	COG1215	transferase activity, transferring glycosyl groups
MM_RS08580	COG0723	plastoquinol--plastocyanin reductase activity
MM_RS08580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MM_RS08595	COG2239	Acts as a magnesium transporter
MM_RS08600	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MM_RS08640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM_RS08675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MM_RS08680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MM_RS08710	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MM_RS08715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MM_RS08720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MM_RS08740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MM_RS08755	COG5012	cobalamin binding
MM_RS08770	COG5012	cobalamin binding
MM_RS08815	COG3613	nucleoside 2-deoxyribosyltransferase
MM_RS08820	COG0826	peptidase U32
MM_RS08840	COG0107	imidazoleglycerol-phosphate synthase activity
MM_RS08850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MM_RS08870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MM_RS08870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MM_RS08875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MM_RS08880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MM_RS08955	COG0535	radical SAM domain protein
MM_RS08965	COG1522	sequence-specific DNA binding
MM_RS09010	COG0535	radical SAM domain protein
MM_RS09015	COG1522	sequence-specific DNA binding
MM_RS09020	COG1522	sequence-specific DNA binding
MM_RS09025	COG1648	precorrin-2 dehydrogenase activity
MM_RS09025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MM_RS09030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MM_RS09035	COG0113	porphobilinogen synthase activity
MM_RS09045	COG0181	hydroxymethylbilane synthase activity
MM_RS09050	COG0167	dihydroorotate dehydrogenase activity
MM_RS09055	COG0543	2 iron, 2 sulfur cluster binding
MM_RS09060	COG0179	Fumarylacetoacetate (FAA) hydrolase
MM_RS09070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MM_RS09090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MM_RS09105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MM_RS09110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MM_RS09130	COG0052	Belongs to the universal ribosomal protein uS2 family
MM_RS09135	COG1355	regulation of microtubule-based process
MM_RS09140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MM_RS09150	COG1304	FMN binding
MM_RS09155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MM_RS09160	COG0142	geranyltranstransferase activity
MM_RS09180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MM_RS09180	COG0574	Belongs to the PEP-utilizing enzyme family
MM_RS09205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS09315	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM_RS09325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MM_RS09330	COG0459	protein refolding
MM_RS09365	COG1592	Rubrerythrin
MM_RS09385	COG1185	polyribonucleotide nucleotidyltransferase activity
MM_RS09445	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MM_RS09450	COG2255	four-way junction helicase activity
MM_RS09475	COG5016	pyruvate
MM_RS09475	COG0511	ligase activity, forming carbon-carbon bonds
MM_RS09480	COG0439	Biotin carboxylase
MM_RS09485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MM_RS09485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MM_RS09530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MM_RS09545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MM_RS09555	COG2181	nitrate reductase activity
MM_RS09555	COG0247	lactate metabolic process
MM_RS09580	COG2081	HI0933 family
MM_RS09605	COG1144	Oxidoreductase
MM_RS09610	COG4608	Belongs to the ABC transporter superfamily
MM_RS09615	COG0444	Belongs to the ABC transporter superfamily
MM_RS09620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM_RS09630	COG0747	negative chemotaxis
MM_RS09645	COG2271	Major facilitator Superfamily
MM_RS09700	COG0163	prenyltransferase activity
MM_RS09710	COG1078	dGTPase activity
MM_RS09715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MM_RS09725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MM_RS09735	COG2264	protein methyltransferase activity
MM_RS09740	COG1185	polyribonucleotide nucleotidyltransferase activity
MM_RS09795	COG0668	transmembrane transport
MM_RS09805	COG3119	arylsulfatase activity
MM_RS09810	COG0641	radical SAM
MM_RS09825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MM_RS09825	COG1796	DNA polymerase
MM_RS09830	COG1793	dna ligase
MM_RS09880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MM_RS09895	COG1335	isochorismatase
MM_RS09910	COG0424	maF-like protein
MM_RS09915	COG0215	cysteine-tRNA ligase activity
MM_RS09935	COG4191	Histidine kinase
MM_RS09940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MM_RS09945	COG1201	RNA secondary structure unwinding
MM_RS09975	COG1598	PFAM Uncharacterised protein family UPF0150
MM_RS09985	COG3339	Conserved Protein
MM_RS10005	COG1247	-acetyltransferase
MM_RS10025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MM_RS10030	COG0697	spore germination
MM_RS10050	COG1739	Uncharacterized protein family UPF0029
MM_RS10060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM_RS10065	COG0765	amino acid transport
MM_RS10075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MM_RS10105	COG0667	Aldo Keto reductase
MM_RS10110	COG2226	methyltransferase
MM_RS10115	COG0693	protein deglycase activity
MM_RS10115	COG0753	catalase activity
MM_RS10130	COG0822	iron-sulfur transferase activity
MM_RS10135	COG1104	cysteine desulfurase activity
MM_RS10140	COG2210	Belongs to the sulfur carrier protein TusA family
MM_RS10145	COG0425	Belongs to the sulfur carrier protein TusA family
MM_RS10150	COG0537	adenosine 5'-monophosphoramidase activity
MM_RS10155	COG4095	Psort location CytoplasmicMembrane, score
MM_RS10175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MM_RS10190	COG0039	L-malate dehydrogenase activity
MM_RS10250	COG1229	Formylmethanofuran dehydrogenase subunit A
MM_RS10255	COG0243	molybdopterin cofactor binding
MM_RS10275	COG3291	Pkd domain containing protein
MM_RS10345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MM_RS10350	COG1122	ATPase activity
MM_RS10390	COG0417	DNA replication proofreading
MM_RS10395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MM_RS10400	COG0573	inorganic phosphate transmembrane transporter activity
MM_RS10410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MM_RS10415	COG0704	Plays a role in the regulation of phosphate uptake
MM_RS10420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MM_RS10425	COG1185	polyribonucleotide nucleotidyltransferase activity
MM_RS10460	COG0316	Belongs to the HesB IscA family
MM_RS10475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MM_RS10530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MM_RS10535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MM_RS10555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MM_RS10580	COG1522	sequence-specific DNA binding
MM_RS10585	COG0436	Aminotransferase
MM_RS10615	COG5012	cobalamin binding
MM_RS10640	COG5012	cobalamin binding
MM_RS10650	COG1372	Participates in initiation and elongation during chromosome replication
MM_RS10650	COG0719	Fe-S assembly protein
MM_RS10655	COG0396	ATPase activity
MM_RS10660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MM_RS10675	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MM_RS10680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MM_RS10685	COG0124	histidyl-tRNA synthetase
MM_RS10715	COG1120	ATPase activity
MM_RS10720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MM_RS10730	COG0157	Belongs to the NadC ModD family
MM_RS10745	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MM_RS10750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MM_RS10760	COG0109	protoheme IX farnesyltransferase activity
MM_RS10765	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MM_RS10770	COG1458	PINc domain ribonuclease
MM_RS10785	COG0390	transport system, permease component
MM_RS10790	COG1132	(ABC) transporter
MM_RS10795	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MM_RS10800	COG0284	orotidine-5'-phosphate decarboxylase activity
MM_RS10835	COG1342	Belongs to the UPF0251 family
MM_RS10840	COG0668	transmembrane transport
MM_RS10920	COG0297	glycogen (starch) synthase activity
MM_RS10940	COG0110	maltose O-acetyltransferase activity
MM_RS11000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MM_RS11005	COG0088	Forms part of the polypeptide exit tunnel
MM_RS11010	COG0089	rRNA binding
MM_RS11020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MM_RS11030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MM_RS11035	COG0255	Belongs to the universal ribosomal protein uL29 family
MM_RS11050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MM_RS11055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MM_RS11065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MM_RS11075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MM_RS11080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MM_RS11100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MM_RS11110	COG0200	Binds to the 23S rRNA
MM_RS11120	COG0563	adenylate kinase activity
MM_RS11125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MM_RS11135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MM_RS11150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MM_RS11160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MM_RS11165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MM_RS11210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MM_RS11215	COG0298	carbon dioxide binding
MM_RS11270	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MM_RS11285	COG2205	protein histidine kinase activity
MM_RS11285	COG2202	Pas domain
MM_RS11295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MM_RS11295	COG0519	Catalyzes the synthesis of GMP from XMP
MM_RS11300	COG1494	fructose-1,6-bisphosphatase
MM_RS11305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MM_RS11340	COG1592	Rubrerythrin
MM_RS11365	COG0420	3'-5' exonuclease activity
MM_RS11370	COG1196	nuclear chromosome segregation
MM_RS11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MM_RS11390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM_RS11420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MM_RS11425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MM_RS11430	COG0315	cyclic pyranopterin monophosphate synthase activity
MM_RS11440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MM_RS11440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MM_RS11480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MM_RS11485	COG1215	transferase activity, transferring glycosyl groups
MM_RS11490	COG0438	transferase activity, transferring glycosyl groups
MM_RS11505	COG0463	Glycosyl transferase, family 2
MM_RS11510	COG0438	transferase activity, transferring glycosyl groups
MM_RS11520	COG0655	NAD(P)H dehydrogenase (quinone) activity
MM_RS11535	COG0456	acetyltransferase
MM_RS11540	COG1473	amidohydrolase
MM_RS11610	COG0785	Cytochrome C biogenesis protein
MM_RS11620	COG2226	methyltransferase
MM_RS11625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MM_RS11650	COG0701	Predicted permease
MM_RS11725	COG0051	transcription antitermination factor activity, RNA binding
MM_RS11730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MM_RS11735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MM_RS11740	COG0049	tRNA binding
MM_RS11760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MM_RS11765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MM_RS11770	COG0085	RNA polymerase activity
MM_RS11775	COG0085	RNA polymerase activity
MM_RS11790	COG3920	Histidine kinase
MM_RS11810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MM_RS11815	COG0402	S-adenosylhomocysteine deaminase activity
MM_RS11825	COG1418	mRNA catabolic process
MM_RS11840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MM_RS11860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MM_RS11865	COG0587	DNA-directed DNA polymerase activity
MM_RS11870	COG0860	N-Acetylmuramoyl-L-alanine amidase
MM_RS11870	COG2247	cell wall binding repeat
MM_RS11880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MM_RS11925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MM_RS11935	COG3875	lactate racemase activity
MM_RS11940	COG3875	lactate racemase activity
MM_RS11950	COG4145	pantothenate transmembrane transporter activity
MM_RS11955	COG0252	asparaginase activity
MM_RS11960	COG0165	Argininosuccinate lyase
MM_RS12000	COG0298	carbon dioxide binding
MM_RS12005	COG0409	Hydrogenase expression formation protein
MM_RS12010	COG0375	protein maturation
MM_RS12015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MM_RS12020	COG0309	Hydrogenase expression formation protein (HypE)
MM_RS12025	COG2111	Na H antiporter
MM_RS12025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MM_RS12030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MM_RS12035	COG3260	NADH ubiquinone oxidoreductase 20
MM_RS12045	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MM_RS12045	COG3261	NADH dehydrogenase
MM_RS12050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MM_RS12060	COG2608	mercury ion transmembrane transporter activity
MM_RS12070	COG2217	Heavy metal translocating P-type atpase
MM_RS12080	COG4895	conserved protein (DUF2196)
MM_RS12100	COG2076	Multidrug Resistance protein
MM_RS12135	COG0028	Belongs to the TPP enzyme family
MM_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
MM_RS12230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MM_RS12240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MM_RS12260	COG0481	GTPase activity
MM_RS12275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MM_RS12280	COG0436	Aminotransferase
MM_RS12290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MM_RS12300	COG0140	phosphoribosyl-ATP diphosphatase activity
MM_RS12300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MM_RS12335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MM_RS12385	COG1122	ATPase activity
MM_RS12390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MM_RS12410	COG0318	PFAM AMP-dependent synthetase and ligase
MM_RS12430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MM_RS12440	COG4555	ABC transporter
MM_RS12445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MM_RS12540	COG0187	DNA topoisomerase II activity
MM_RS12545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MM_RS12550	COG0326	Molecular chaperone. Has ATPase activity
MM_RS12575	COG0412	Dienelactone hydrolase
MM_RS12585	COG5012	cobalamin binding
MM_RS12600	COG0671	phosphoesterase, PA-phosphatase related
MM_RS12610	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MM_RS12615	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MM_RS12730	COG1131	(ABC) transporter
MM_RS12745	COG0601	transmembrane transport
MM_RS12755	COG0747	negative chemotaxis
MM_RS12770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MM_RS12775	COG0105	UTP biosynthetic process
MM_RS12860	COG1007	ATP synthesis coupled electron transport
MM_RS12865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM_RS12875	COG0713	ATP synthesis coupled electron transport
MM_RS12895	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MM_RS12900	COG0649	NAD binding
MM_RS12905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM_RS12910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM_RS12930	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MM_RS12940	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MM_RS12970	COG0569	domain protein
MM_RS12975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MM_RS12985	COG0484	heat shock protein binding
MM_RS12990	COG0443	Heat shock 70 kDa protein
MM_RS12995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MM_RS13050	COG0745	RESPONSE REGULATOR receiver
MM_RS13055	COG0301	tRNA thio-modification
MM_RS13060	COG2205	protein histidine kinase activity
MM_RS13065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MM_RS13075	COG0589	response to stress
MM_RS13105	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MM_RS13125	COG3174	membrane
MM_RS13160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MM_RS13165	COG2890	protein-(glutamine-N5) methyltransferase activity
MM_RS13170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MM_RS13175	COG2816	NAD+ diphosphatase activity
MM_RS13240	COG0753	catalase activity
MM_RS13260	COG1162	GTPase activity
MM_RS13300	COG0601	transmembrane transport
MM_RS13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM_RS13310	COG0444	Belongs to the ABC transporter superfamily
MM_RS13315	COG4608	Belongs to the ABC transporter superfamily
MM_RS13325	COG1321	iron dependent repressor
MM_RS13340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MM_RS13340	COG1918	ferrous iron import across plasma membrane
MM_RS13370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MM_RS13375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MM_RS13380	COG0805	protein transport
MM_RS13385	COG0805	protein transport
MM_RS13410	COG0697	spore germination
MM_RS13435	COG1945	arginine decarboxylase activity
MM_RS13440	COG0145	ligase activity
MM_RS13460	COG1451	nucleotide metabolic process
MM_RS13495	COG2361	Protein of unknown function DUF86
MM_RS13515	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MM_RS13520	COG1205	dead DEAH box helicase
MM_RS13520	COG1111	helicase
MM_RS13530	COG1704	LemA family
MM_RS13555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MM_RS13575	COG1185	polyribonucleotide nucleotidyltransferase activity
MM_RS13580	COG1185	polyribonucleotide nucleotidyltransferase activity
MM_RS13605	COG2205	protein histidine kinase activity
MM_RS13620	COG0281	malic enzyme
MM_RS13630	COG4106	trans-aconitate 2-methyltransferase activity
MM_RS13650	COG0668	transmembrane transport
MM_RS13655	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MM_RS13665	COG0598	Magnesium transport protein CorA
MM_RS13695	COG2414	aldehyde ferredoxin oxidoreductase
MM_RS13700	COG3920	Histidine kinase
MM_RS13715	COG0436	Aminotransferase
MM_RS13735	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MM_RS13740	COG0826	peptidase U32
MM_RS13760	COG1047	Peptidyl-prolyl cis-trans
MM_RS13765	COG0864	Transcriptional regulator
MM_RS13775	COG0456	acetyltransferase
MM_RS13780	COG0456	acetyltransferase
MM_RS13785	COG0530	calcium, potassium:sodium antiporter activity
MM_RS13795	COG1115	amino acid carrier protein
MM_RS13810	COG1136	(ABC) transporter
MM_RS13820	COG0714	Associated with various cellular activities
MM_RS13930	COG1032	radical SAM domain protein
MM_RS14000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MM_RS14010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM_RS14015	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MM_RS14055	COG0460	homoserine dehydrogenase
MM_RS14060	COG1793	dna ligase
MM_RS14065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MM_RS14080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MM_RS14100	COG0590	tRNA wobble adenosine to inosine editing
MM_RS14105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MM_RS14105	COG0574	Belongs to the PEP-utilizing enzyme family
MM_RS14145	COG2095	MarC family integral membrane protein
MM_RS14155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MM_RS14190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM_RS14205	COG0494	nUDIX hydrolase
MM_RS14235	COG3920	Histidine kinase
MM_RS14240	COG2195	Cleaves the N-terminal amino acid of tripeptides
MM_RS14255	COG0628	permease
MM_RS14370	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MM_RS14405	COG1254	Belongs to the acylphosphatase family
MM_RS14430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MM_RS14440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MM_RS14445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MM_RS14475	COG2003	Belongs to the UPF0758 family
MM_RS14485	COG0746	molybdenum cofactor guanylyltransferase activity
MM_RS14505	COG1741	Belongs to the pirin family
MM_RS14550	COG0367	asparagine synthase
MM_RS14615	COG0512	Glutamine amidotransferase of anthranilate synthase
MM_RS14615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MM_RS14625	COG0135	phosphoribosylanthranilate isomerase activity
MM_RS14630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MM_RS14635	COG0159	tryptophan synthase activity
MM_RS14640	COG0133	tryptophan synthase activity
MM_RS14645	COG0134	indole-3-glycerol-phosphate synthase activity
MM_RS14650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MM_RS14655	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MM_RS14675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MM_RS14695	COG1136	(ABC) transporter
MM_RS14715	COG0148	phosphopyruvate hydratase activity
MM_RS14740	COG0028	Belongs to the TPP enzyme family
MM_RS14785	COG0730	response to heat
MM_RS14790	COG4591	ABC-type transport system involved in lipoprotein release permease component
MM_RS14805	COG1846	Transcriptional regulator
MM_RS14815	COG0628	permease
MM_RS14830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MM_RS14930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MM_RS14935	COG0628	permease
MM_RS14955	COG0784	Response regulator, receiver
MM_RS14960	COG2205	protein histidine kinase activity
MM_RS14960	COG5002	protein histidine kinase activity
MM_RS14960	COG0784	Response regulator, receiver
MM_RS14985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MM_RS14985	COG2205	protein histidine kinase activity
MM_RS14995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MM_RS15000	COG3431	PFAM Phosphate-starvation-inducible E
MM_RS15015	COG1136	(ABC) transporter
MM_RS15030	COG1741	Belongs to the pirin family
MM_RS15085	COG1741	Belongs to the pirin family
MM_RS15100	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MM_RS15140	COG0667	Aldo Keto reductase
MM_RS15175	COG1295	ribonuclease BN
MM_RS15230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MM_RS15265	COG1045	serine acetyltransferase
MM_RS15295	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MM_RS15345	COG0745	RESPONSE REGULATOR receiver
MM_RS15350	COG0745	RESPONSE REGULATOR receiver
MM_RS15355	COG3920	Histidine kinase
MM_RS15400	COG5012	cobalamin binding
MM_RS15420	COG3920	Histidine kinase
MM_RS15455	COG1373	ATPase (AAA superfamily
MM_RS15490	COG4804	nuclease activity
MM_RS15575	COG0588	phosphoglycerate mutase activity
MM_RS15610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MM_RS15640	COG2153	protein acetylation
MM_RS15660	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MM_RS15670	COG1324	tolerance protein
MM_RS15705	COG1122	ATPase activity
MM_RS15730	COG1136	(ABC) transporter
MM_RS15755	COG3391	amine dehydrogenase activity
MM_RS15830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MM_RS15835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MM_RS15865	COG0297	glycogen (starch) synthase activity
MM_RS15875	COG1064	alcohol dehydrogenase
MM_RS15885	COG2843	Capsule synthesis protein
MM_RS15895	COG0658	competence protein
MM_RS15895	COG2333	competence protein COMEC
MM_RS15950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MM_RS15965	COG2326	polyphosphate kinase activity
MM_RS15970	COG0477	Major facilitator Superfamily
MM_RS15995	COG0551	DNA topoisomerase type I activity
MM_RS15995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MM_RS16005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MM_RS16045	COG0693	protein deglycase activity
MM_RS16055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MM_RS16070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MM_RS16070	COG4451	ribulose bisphosphate carboxylase, small
MM_RS16115	COG1136	(ABC) transporter
MM_RS16125	COG0577	efflux transmembrane transporter activity
MM_RS16125	COG1136	(ABC) transporter
MM_RS16130	COG2205	protein histidine kinase activity
MM_RS16140	COG2205	protein histidine kinase activity
MM_RS16165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MM_RS16180	COG0058	SHG alpha-glucan phosphorylase activity
MM_RS16190	COG3485	protocatechuate 3,4-dioxygenase
MM_RS16225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MM_RS16230	COG0655	NAD(P)H dehydrogenase (quinone) activity
MM_RS16240	COG2814	Major facilitator Superfamily
MM_RS16275	COG0671	phosphoesterase, PA-phosphatase related
MM_RS16305	COG0501	Belongs to the peptidase M48B family
MM_RS16310	COG1131	(ABC) transporter
MM_RS16340	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MM_RS16375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MM_RS16380	COG0708	Exodeoxyribonuclease III
MM_RS16395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MM_RS16430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MM_RS16515	COG3063	Type IV pilus biogenesis stability protein PilW
MM_RS16525	COG3291	Pkd domain containing protein
MM_RS16535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MM_RS16545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MM_RS16545	COG0674	pyruvate-flavodoxin oxidoreductase activity
MM_RS16565	COG0531	amino acid
MM_RS16570	COG0426	domain, Protein
MM_RS16580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MM_RS16605	COG0534	Mate efflux family protein
MM_RS16610	COG1846	Transcriptional regulator
MM_RS16630	COG1073	alpha beta
MM_RS16635	COG0697	spore germination
MM_RS16645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MM_RS16650	COG0392	lysyltransferase activity
MM_RS16650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MM_RS16660	COG0534	Mate efflux family protein
MM_RS16665	COG2205	protein histidine kinase activity
MM_RS16665	COG2202	Pas domain
MM_RS16670	COG0784	Response regulator, receiver
MM_RS16675	COG0826	peptidase U32
MM_RS16680	COG0640	Transcriptional regulator
MM_RS16700	COG1151	hydroxylamine reductase activity
MM_RS16770	COG0300	oxidoreductase activity
MM_RS16790	COG0306	phosphate transporter
MM_RS16810	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MM_RS16815	COG0352	thiamine-phosphate diphosphorylase activity
MM_RS16860	COG3903	Transcriptional regulator
MM_RS16860	COG3629	intracellular signal transduction
MM_RS16935	COG1511	domain protein
MM_RS16935	COG3264	Mechanosensitive ion channel
MM_RS16945	COG0668	transmembrane transport
MM_RS16950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MM_RS16960	COG2221	Nitrite and sulphite reductase 4Fe-4S
MM_RS17000	COG2814	Major facilitator Superfamily
MM_RS17015	COG1253	flavin adenine dinucleotide binding
MM_RS17030	COG1836	PFAM Integral membrane protein DUF92
MM_RS17035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MM_RS17065	COG1408	metallophosphoesterase
MM_RS17085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MM_RS17090	COG0556	nucleotide-excision repair
MM_RS17095	COG0322	excinuclease ABC activity
MM_RS17100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MM_RS17155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MM_RS17160	COG1061	Type III restriction enzyme res subunit
MM_RS17240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MM_RS17250	COG0747	negative chemotaxis
MM_RS17255	COG4608	Belongs to the ABC transporter superfamily
MM_RS17265	COG1301	dicarboxylic acid transport
MM_RS17275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MM_RS17285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MM_RS17300	COG0562	UDP-galactopyranose mutase
MM_RS17315	COG5012	cobalamin binding
MM_RS17405	COG0653	protein targeting
MM_RS17420	COG1337	RAMP superfamily
MM_RS17445	COG3344	reverse transcriptase
MM_RS17515	COG1215	transferase activity, transferring glycosyl groups
MM_RS17520	COG0438	transferase activity, transferring glycosyl groups
MM_RS17590	COG4935	Belongs to the peptidase S8 family
MM_RS17590	COG1404	Belongs to the peptidase S8 family
MM_RS17670	COG1598	PFAM Uncharacterised protein family UPF0150
MM_RS17715	COG1742	UPF0060 membrane protein
MM_RS17795	COG0589	response to stress
MM_RS17855	COG1598	PFAM Uncharacterised protein family UPF0150
MM_RS17985	COG2205	protein histidine kinase activity
MM_RS18020	COG4251	negative regulation of phosphorylation
MM_RS18120	COG1773	rubredoxin