locus-tag	class	description
MSMAL_RS00060	COG0516	GMP reductase activity
MSMAL_RS00060	COG0517	IMP dehydrogenase activity
MSMAL_RS00065	COG0516	GMP reductase activity
MSMAL_RS00095	COG0430	RNA-3'-phosphate cyclase activity
MSMAL_RS00100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAL_RS00120	COG0456	acetyltransferase
MSMAL_RS00130	COG0277	FAD linked oxidase domain protein
MSMAL_RS00135	COG0247	lactate metabolic process
MSMAL_RS00160	COG0084	hydrolase, TatD family'
MSMAL_RS00170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAL_RS00220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAL_RS00225	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSMAL_RS00230	COG2022	thiamine diphosphate biosynthetic process
MSMAL_RS00235	COG2890	protein-(glutamine-N5) methyltransferase activity
MSMAL_RS00245	COG1605	Chorismate mutase
MSMAL_RS00245	COG0287	Prephenate dehydrogenase
MSMAL_RS00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSMAL_RS00255	COG0710	3-dehydroquinate dehydratase activity
MSMAL_RS00260	COG1465	3-dehydroquinate synthase
MSMAL_RS00265	COG1830	Aldolase
MSMAL_RS00270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAL_RS00270	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAL_RS00275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSMAL_RS00325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS00355	COG1850	ribulose-bisphosphate carboxylase activity
MSMAL_RS00360	COG0009	L-threonylcarbamoyladenylate synthase
MSMAL_RS00410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSMAL_RS00415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSMAL_RS00420	COG0501	Belongs to the peptidase M48B family
MSMAL_RS00430	COG1715	Restriction endonuclease
MSMAL_RS00435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MSMAL_RS00450	COG2264	protein methyltransferase activity
MSMAL_RS00460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSMAL_RS00465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAL_RS00470	COG0154	amidase activity
MSMAL_RS00475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAL_RS00480	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSMAL_RS00495	COG1469	GTP cyclohydrolase I activity
MSMAL_RS00505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSMAL_RS00515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAL_RS00515	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAL_RS00520	COG0514	ATP-dependent DNA helicase (RecQ)
MSMAL_RS00540	COG0540	Belongs to the ATCase OTCase family
MSMAL_RS00545	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MSMAL_RS00595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSMAL_RS00600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSMAL_RS00665	COG0463	Glycosyl transferase, family 2
MSMAL_RS00675	COG1216	Glycosyl transferase, family 2
MSMAL_RS00685	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS00705	COG1091	dTDP-4-dehydrorhamnose reductase activity
MSMAL_RS00720	COG0463	Glycosyl transferase, family 2
MSMAL_RS00735	COG2361	Protein of unknown function DUF86
MSMAL_RS00740	COG2361	Protein of unknown function DUF86
MSMAL_RS00750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSMAL_RS00765	COG1254	Belongs to the acylphosphatase family
MSMAL_RS00790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MSMAL_RS00795	COG0673	inositol 2-dehydrogenase activity
MSMAL_RS00840	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS00845	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS00850	COG1216	Glycosyl transferase, family 2
MSMAL_RS00860	COG1216	Glycosyl transferase, family 2
MSMAL_RS00860	COG0463	Glycosyl transferase, family 2
MSMAL_RS00865	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS00865	COG0297	glycogen (starch) synthase activity
MSMAL_RS00870	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS00885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSMAL_RS00890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSMAL_RS00895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MSMAL_RS00920	COG0463	Glycosyl transferase, family 2
MSMAL_RS00925	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS00945	COG0673	inositol 2-dehydrogenase activity
MSMAL_RS00950	COG1216	Glycosyl transferase, family 2
MSMAL_RS00950	COG1442	glycosyl transferase family 8
MSMAL_RS00985	COG1891	lyase activity
MSMAL_RS00990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSMAL_RS01000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSMAL_RS01020	COG0560	Phosphoserine phosphatase
MSMAL_RS01020	COG3830	Belongs to the UPF0237 family
MSMAL_RS01040	COG0109	protoheme IX farnesyltransferase activity
MSMAL_RS01045	COG0343	queuine tRNA-ribosyltransferase activity
MSMAL_RS01065	COG0459	protein refolding
MSMAL_RS01085	COG4251	negative regulation of phosphorylation
MSMAL_RS01090	COG4251	negative regulation of phosphorylation
MSMAL_RS01095	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAL_RS01100	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAL_RS01110	COG1372	Participates in initiation and elongation during chromosome replication
MSMAL_RS01110	COG0719	Fe-S assembly protein
MSMAL_RS01115	COG0396	ATPase activity
MSMAL_RS01140	COG0012	GTP binding
MSMAL_RS01185	COG1584	GPR1 FUN34 yaaH family protein
MSMAL_RS01195	COG5012	cobalamin binding
MSMAL_RS01200	COG0523	cobalamin synthesis protein
MSMAL_RS01215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAL_RS01220	COG0784	Response regulator, receiver
MSMAL_RS01235	COG3261	NADH dehydrogenase
MSMAL_RS01235	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MSMAL_RS01240	COG0651	ATP synthesis coupled electron transport
MSMAL_RS01255	COG0651	ATP synthesis coupled electron transport
MSMAL_RS01265	COG4152	abc transporter atp-binding protein
MSMAL_RS01275	COG5012	cobalamin binding
MSMAL_RS01320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MSMAL_RS01330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAL_RS01335	COG0303	'Molybdopterin
MSMAL_RS01370	COG0640	Transcriptional regulator
MSMAL_RS01380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAL_RS01385	COG1122	ATPase activity
MSMAL_RS01390	COG1122	ATPase activity
MSMAL_RS01395	COG1268	BioY protein
MSMAL_RS01405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSMAL_RS01415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSMAL_RS01415	COG1918	ferrous iron import across plasma membrane
MSMAL_RS01430	COG1196	nuclear chromosome segregation
MSMAL_RS01440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSMAL_RS01460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSMAL_RS01505	COG0535	radical SAM domain protein
MSMAL_RS01515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSMAL_RS01520	COG0081	regulation of translation
MSMAL_RS01525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSMAL_RS01540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSMAL_RS01555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS01570	COG0473	3-isopropylmalate dehydrogenase activity
MSMAL_RS01575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAL_RS01630	COG0489	protein tyrosine kinase activity
MSMAL_RS01635	COG1342	Belongs to the UPF0251 family
MSMAL_RS01650	COG0489	protein tyrosine kinase activity
MSMAL_RS01675	COG2048	Heterodisulfide reductase, subunit B
MSMAL_RS01705	COG0024	Methionine aminopeptidase
MSMAL_RS01845	COG0067	glutamate synthase
MSMAL_RS01860	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MSMAL_RS01885	COG0347	Belongs to the P(II) protein family
MSMAL_RS01890	COG0004	ammonium transporteR
MSMAL_RS01915	COG1136	(ABC) transporter
MSMAL_RS01925	COG0577	efflux transmembrane transporter activity
MSMAL_RS01930	COG1136	(ABC) transporter
MSMAL_RS01940	COG2205	protein histidine kinase activity
MSMAL_RS01945	COG0577	efflux transmembrane transporter activity
MSMAL_RS01960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MSMAL_RS01965	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MSMAL_RS01975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MSMAL_RS01995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAL_RS02000	COG4962	Type ii secretion system protein e
MSMAL_RS02015	COG0456	acetyltransferase
MSMAL_RS02020	COG1509	lysine 2,3-aminomutase activity
MSMAL_RS02025	COG4651	solute:proton antiporter activity
MSMAL_RS02025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSMAL_RS02055	COG1476	TRANSCRIPTIONal
MSMAL_RS02075	COG0010	Belongs to the arginase family
MSMAL_RS02090	COG0494	nUDIX hydrolase
MSMAL_RS02095	COG5549	protein import
MSMAL_RS02095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSMAL_RS02135	COG1122	ATPase activity
MSMAL_RS02140	COG2217	Heavy metal translocating P-type atpase
MSMAL_RS02160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSMAL_RS02170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSMAL_RS02180	COG1584	GPR1 FUN34 yaaH family protein
MSMAL_RS02185	COG0500	methyltransferase
MSMAL_RS02205	COG0138	bifunctional purine biosynthesis protein purh
MSMAL_RS02210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAL_RS02215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAL_RS02225	COG0310	cobalt ion transport
MSMAL_RS02230	COG2226	methyltransferase
MSMAL_RS02250	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAL_RS02255	COG1122	ATPase activity
MSMAL_RS02260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSMAL_RS02300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MSMAL_RS02305	COG0183	Belongs to the thiolase family
MSMAL_RS02320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSMAL_RS02320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSMAL_RS02325	COG0616	signal peptide processing
MSMAL_RS02330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSMAL_RS02380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSMAL_RS02385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS02390	COG0321	lipoyl(octanoyl) transferase activity
MSMAL_RS02390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSMAL_RS02405	COG2155	Conserved Protein
MSMAL_RS02410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSMAL_RS02445	COG0864	Transcriptional regulator
MSMAL_RS02450	COG0640	Transcriptional regulator
MSMAL_RS02455	COG1216	Glycosyl transferase, family 2
MSMAL_RS02480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAL_RS02505	COG0303	'Molybdopterin
MSMAL_RS02510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSMAL_RS02515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSMAL_RS02530	COG0517	IMP dehydrogenase activity
MSMAL_RS02540	COG0402	S-adenosylhomocysteine deaminase activity
MSMAL_RS02560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSMAL_RS02565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSMAL_RS02570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MSMAL_RS02575	COG0450	alkyl hydroperoxide reductase
MSMAL_RS02590	COG1983	PspC domain protein
MSMAL_RS02595	COG0552	protein localization to endoplasmic reticulum
MSMAL_RS02640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSMAL_RS02655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS02730	COG1269	ATP hydrolysis coupled proton transport
MSMAL_RS02755	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MSMAL_RS02760	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MSMAL_RS02795	COG4572	Cation transport regulator
MSMAL_RS02865	COG2144	transferase activity, transferring acyl groups
MSMAL_RS02875	COG1433	Dinitrogenase iron-molybdenum cofactor
MSMAL_RS02875	COG0535	radical SAM domain protein
MSMAL_RS02885	COG1433	Dinitrogenase iron-molybdenum cofactor
MSMAL_RS02885	COG0535	radical SAM domain protein
MSMAL_RS02890	COG0720	synthase
MSMAL_RS02895	COG0602	queuosine metabolic process
MSMAL_RS02905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSMAL_RS02930	COG1063	alcohol dehydrogenase
MSMAL_RS02935	COG2226	methyltransferase
MSMAL_RS02940	COG0513	Belongs to the DEAD box helicase family
MSMAL_RS02965	COG0798	PFAM Bile acid sodium symporter
MSMAL_RS02990	COG1742	UPF0060 membrane protein
MSMAL_RS03000	COG0004	ammonium transporteR
MSMAL_RS03005	COG0347	Belongs to the P(II) protein family
MSMAL_RS03010	COG2226	methyltransferase
MSMAL_RS03025	COG3842	ATPase activity
MSMAL_RS03030	COG4149	molybdate abc transporter
MSMAL_RS03035	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAL_RS03040	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MSMAL_RS03060	COG0347	Belongs to the P(II) protein family
MSMAL_RS03070	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSMAL_RS03075	COG0644	oxidoreductase
MSMAL_RS03130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSMAL_RS03135	COG0442	prolyl-tRNA aminoacylation
MSMAL_RS03165	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSMAL_RS03170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSMAL_RS03185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSMAL_RS03190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSMAL_RS03195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSMAL_RS03290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSMAL_RS03305	COG1363	Peptidase, m42
MSMAL_RS03325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSMAL_RS03345	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSMAL_RS03405	COG0596	Alpha beta hydrolase
MSMAL_RS03410	COG0531	amino acid
MSMAL_RS03450	COG0662	Cupin 2, conserved barrel domain protein
MSMAL_RS03460	COG1408	metallophosphoesterase
MSMAL_RS03490	COG0557	exoribonuclease II activity
MSMAL_RS03530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MSMAL_RS03535	COG1518	maintenance of DNA repeat elements
MSMAL_RS03575	COG1203	CRISPR-associated helicase, Cas3
MSMAL_RS03605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAL_RS03620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MSMAL_RS03625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSMAL_RS03630	COG1785	Belongs to the alkaline phosphatase family
MSMAL_RS03635	COG3431	PFAM Phosphate-starvation-inducible E
MSMAL_RS03640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSMAL_RS03655	COG0704	Plays a role in the regulation of phosphate uptake
MSMAL_RS03660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSMAL_RS03660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSMAL_RS03710	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS03725	COG0371	Dehydrogenase
MSMAL_RS03755	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAL_RS03785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSMAL_RS03790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSMAL_RS03805	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSMAL_RS03830	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAL_RS03835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSMAL_RS03845	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAL_RS03865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSMAL_RS03870	COG1331	Highly conserved protein containing a thioredoxin domain
MSMAL_RS03910	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSMAL_RS03940	COG2033	superoxide reductase activity
MSMAL_RS03950	COG0431	NADPH-dependent FMN reductase
MSMAL_RS03970	COG0426	domain, Protein
MSMAL_RS03975	COG3527	Alpha-acetolactate decarboxylase
MSMAL_RS03990	COG0473	3-isopropylmalate dehydrogenase activity
MSMAL_RS04005	COG0066	3-isopropylmalate dehydratase activity
MSMAL_RS04040	COG1216	Glycosyl transferase, family 2
MSMAL_RS04040	COG0463	Glycosyl transferase, family 2
MSMAL_RS04045	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS04065	COG2226	methyltransferase
MSMAL_RS04070	COG0640	Transcriptional regulator
MSMAL_RS04080	COG0493	'glutamate synthase
MSMAL_RS04095	COG0864	Transcriptional regulator
MSMAL_RS04100	COG0778	Nitroreductase
MSMAL_RS04105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSMAL_RS04110	COG0440	acetolactate synthase activity
MSMAL_RS04115	COG0028	Belongs to the TPP enzyme family
MSMAL_RS04120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAL_RS04145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAL_RS04190	COG0038	chloride channel
MSMAL_RS04195	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAL_RS04200	COG0280	phosphate acetyltransferase
MSMAL_RS04205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSMAL_RS04245	COG1573	uracil-dna glycosylase
MSMAL_RS04250	COG0126	phosphoglycerate kinase activity
MSMAL_RS04265	COG0071	Belongs to the small heat shock protein (HSP20) family
MSMAL_RS04295	COG1373	ATPase (AAA superfamily
MSMAL_RS04315	COG0456	acetyltransferase
MSMAL_RS04320	COG3613	nucleoside 2-deoxyribosyltransferase
MSMAL_RS04330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSMAL_RS04335	COG0517	IMP dehydrogenase activity
MSMAL_RS04340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSMAL_RS04400	COG0310	cobalt ion transport
MSMAL_RS04405	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSMAL_RS04415	COG1122	ATPase activity
MSMAL_RS04435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSMAL_RS04445	COG0561	phosphatase activity
MSMAL_RS04495	COG2226	methyltransferase
MSMAL_RS04505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS04525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSMAL_RS04530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSMAL_RS04535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSMAL_RS04540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSMAL_RS04560	COG3118	belongs to the thioredoxin family
MSMAL_RS04595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAL_RS04600	COG0732	type I restriction modification DNA specificity domain
MSMAL_RS04605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAL_RS04625	COG1121	(ABC) transporter
MSMAL_RS04630	COG4581	dead DEAH box helicase
MSMAL_RS04635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MSMAL_RS04645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSMAL_RS04645	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAL_RS04650	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSMAL_RS04760	COG1192	Involved in chromosome partitioning
MSMAL_RS04790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAL_RS04825	COG5658	integral membrane protein
MSMAL_RS04840	COG1047	Peptidyl-prolyl cis-trans
MSMAL_RS04880	COG0714	Associated with various cellular activities
MSMAL_RS04890	COG0077	Prephenate dehydratase
MSMAL_RS04890	COG1605	Chorismate mutase
MSMAL_RS04930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAL_RS04935	COG1733	regulation of RNA biosynthetic process
MSMAL_RS04940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAL_RS04950	COG0045	succinate-CoA ligase (ADP-forming) activity
MSMAL_RS04950	COG1042	CoA-binding domain protein
MSMAL_RS04950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAL_RS04955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MSMAL_RS04990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAL_RS05010	COG1846	Transcriptional regulator
MSMAL_RS05020	COG0534	Mate efflux family protein
MSMAL_RS05035	COG0432	Pfam Uncharacterised protein family UPF0047
MSMAL_RS05040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSMAL_RS05050	COG0351	phosphomethylpyrimidine kinase
MSMAL_RS05055	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MSMAL_RS05075	COG3290	protein histidine kinase activity
MSMAL_RS05075	COG0840	transmembrane signaling receptor activity
MSMAL_RS05080	COG0835	chemotaxis
MSMAL_RS05090	COG2201	protein-glutamate methylesterase activity
MSMAL_RS05095	COG2201	protein-glutamate methylesterase activity
MSMAL_RS05110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSMAL_RS05200	COG0535	radical SAM domain protein
MSMAL_RS05215	COG1234	tRNA 3'-trailer cleavage
MSMAL_RS05225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS05240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSMAL_RS05245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSMAL_RS05250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSMAL_RS05255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAL_RS05265	COG1125	glycine betaine transport
MSMAL_RS05265	COG0517	IMP dehydrogenase activity
MSMAL_RS05275	COG1174	glycine betaine transport
MSMAL_RS05325	COG1945	arginine decarboxylase activity
MSMAL_RS05335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSMAL_RS05340	COG0495	leucyl-tRNA aminoacylation
MSMAL_RS05345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MSMAL_RS05435	COG0653	protein targeting
MSMAL_RS05440	COG0426	domain, Protein
MSMAL_RS05450	COG0129	dihydroxy-acid dehydratase activity
MSMAL_RS05460	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSMAL_RS05515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAL_RS05520	COG3177	Filamentation induced by cAMP protein fic
MSMAL_RS05560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSMAL_RS05560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSMAL_RS05615	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAL_RS05620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAL_RS05625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MSMAL_RS05625	COG0617	tRNA 3'-terminal CCA addition
MSMAL_RS05625	COG0517	IMP dehydrogenase activity
MSMAL_RS05630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MSMAL_RS05640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSMAL_RS05645	COG0436	Aminotransferase
MSMAL_RS05655	COG0517	IMP dehydrogenase activity
MSMAL_RS05655	COG0516	GMP reductase activity
MSMAL_RS05685	COG0668	transmembrane transport
MSMAL_RS05700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSMAL_RS05755	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MSMAL_RS05875	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAL_RS05935	COG2361	Protein of unknown function DUF86
MSMAL_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
MSMAL_RS05960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSMAL_RS05965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSMAL_RS05995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MSMAL_RS06010	COG5012	cobalamin binding
MSMAL_RS06050	COG4191	Histidine kinase
MSMAL_RS06050	COG0784	Response regulator, receiver
MSMAL_RS06080	COG5310	Homospermidine synthase
MSMAL_RS06100	COG3189	MarR family transcriptional regulator
MSMAL_RS06130	COG0210	DNA helicase
MSMAL_RS06210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSMAL_RS06215	COG0151	Belongs to the GarS family
MSMAL_RS06225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSMAL_RS06240	COG1138	Cytochrome C-type biogenesis protein
MSMAL_RS06290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSMAL_RS06335	COG1067	ATP-dependent peptidase activity
MSMAL_RS06335	COG0470	DNA polymerase III
MSMAL_RS06345	COG0312	modulator of DNA gyrase
MSMAL_RS06350	COG0589	response to stress
MSMAL_RS06365	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAL_RS06385	COG0504	CTP synthase activity
MSMAL_RS06410	COG0534	Mate efflux family protein
MSMAL_RS06415	COG0585	pseudouridine synthase activity
MSMAL_RS06440	COG0822	iron-sulfur transferase activity
MSMAL_RS06455	COG1346	cytolysis
MSMAL_RS06515	COG1492	cobalamin metabolic process
MSMAL_RS06525	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSMAL_RS06565	COG3830	Belongs to the UPF0237 family
MSMAL_RS06570	COG2848	UPF0210 protein
MSMAL_RS06585	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MSMAL_RS06590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSMAL_RS06610	COG0017	Asparaginyl-tRNA synthetase
MSMAL_RS06615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSMAL_RS06620	COG0459	protein refolding
MSMAL_RS06630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSMAL_RS06695	COG1233	COG1233 Phytoene dehydrogenase and related
MSMAL_RS06710	COG0589	response to stress
MSMAL_RS06725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAL_RS06735	COG1012	belongs to the aldehyde dehydrogenase family
MSMAL_RS06740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MSMAL_RS06785	COG0505	Belongs to the CarA family
MSMAL_RS06790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSMAL_RS06795	COG0137	argininosuccinate synthase activity
MSMAL_RS06850	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAL_RS06880	COG2226	methyltransferase
MSMAL_RS06900	COG2226	methyltransferase
MSMAL_RS06905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSMAL_RS06950	COG0444	Belongs to the ABC transporter superfamily
MSMAL_RS06955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAL_RS07035	COG0653	protein targeting
MSMAL_RS07070	COG0028	Belongs to the TPP enzyme family
MSMAL_RS07135	COG0730	response to heat
MSMAL_RS07140	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSMAL_RS07165	COG0628	permease
MSMAL_RS07180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSMAL_RS07295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSMAL_RS07300	COG0628	permease
MSMAL_RS07320	COG0784	Response regulator, receiver
MSMAL_RS07325	COG5002	protein histidine kinase activity
MSMAL_RS07325	COG2205	protein histidine kinase activity
MSMAL_RS07325	COG0784	Response regulator, receiver
MSMAL_RS07350	COG3920	Histidine kinase
MSMAL_RS07360	COG2205	protein histidine kinase activity
MSMAL_RS07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSMAL_RS07370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAL_RS07375	COG3431	PFAM Phosphate-starvation-inducible E
MSMAL_RS07380	COG1136	(ABC) transporter
MSMAL_RS07380	COG0577	efflux transmembrane transporter activity
MSMAL_RS07390	COG1136	(ABC) transporter
MSMAL_RS07405	COG1741	Belongs to the pirin family
MSMAL_RS07440	COG1741	Belongs to the pirin family
MSMAL_RS07455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MSMAL_RS07495	COG0667	Aldo Keto reductase
MSMAL_RS07540	COG1295	ribonuclease BN
MSMAL_RS07595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAL_RS07635	COG1045	serine acetyltransferase
MSMAL_RS07665	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSMAL_RS07735	COG0745	RESPONSE REGULATOR receiver
MSMAL_RS07740	COG0745	RESPONSE REGULATOR receiver
MSMAL_RS07780	COG5012	cobalamin binding
MSMAL_RS07835	COG1373	ATPase (AAA superfamily
MSMAL_RS07865	COG0732	type I restriction modification DNA specificity domain
MSMAL_RS07880	COG1196	nuclear chromosome segregation
MSMAL_RS07980	COG0588	phosphoglycerate mutase activity
MSMAL_RS08010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSMAL_RS08045	COG2153	protein acetylation
MSMAL_RS08065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAL_RS08075	COG1324	tolerance protein
MSMAL_RS08110	COG1122	ATPase activity
MSMAL_RS08135	COG1136	(ABC) transporter
MSMAL_RS08160	COG3391	amine dehydrogenase activity
MSMAL_RS08220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAL_RS08225	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MSMAL_RS08240	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS08260	COG2333	competence protein COMEC
MSMAL_RS08260	COG0658	competence protein
MSMAL_RS08285	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MSMAL_RS08300	COG2326	polyphosphate kinase activity
MSMAL_RS08330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSMAL_RS08340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSMAL_RS08380	COG0693	protein deglycase activity
MSMAL_RS08385	COG0626	cystathionine gamma-synthase activity
MSMAL_RS08390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MSMAL_RS08400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSMAL_RS08400	COG4451	ribulose bisphosphate carboxylase, small
MSMAL_RS08445	COG1136	(ABC) transporter
MSMAL_RS08455	COG1136	(ABC) transporter
MSMAL_RS08455	COG0577	efflux transmembrane transporter activity
MSMAL_RS08465	COG2205	protein histidine kinase activity
MSMAL_RS08500	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSMAL_RS08515	COG0058	SHG alpha-glucan phosphorylase activity
MSMAL_RS08525	COG3485	protocatechuate 3,4-dioxygenase
MSMAL_RS08565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSMAL_RS08570	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAL_RS08580	COG2814	Major facilitator Superfamily
MSMAL_RS08620	COG0671	phosphoesterase, PA-phosphatase related
MSMAL_RS08650	COG0501	Belongs to the peptidase M48B family
MSMAL_RS08655	COG1131	(ABC) transporter
MSMAL_RS08685	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAL_RS08695	COG0732	type I restriction modification DNA specificity domain
MSMAL_RS08720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAL_RS08820	COG0798	PFAM Bile acid sodium symporter
MSMAL_RS08835	COG0110	maltose O-acetyltransferase activity
MSMAL_RS08880	COG0640	Transcriptional regulator
MSMAL_RS08890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSMAL_RS08985	COG0798	PFAM Bile acid sodium symporter
MSMAL_RS09010	COG3383	formate dehydrogenase (NAD+) activity
MSMAL_RS09030	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS09065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSMAL_RS09095	COG0210	DNA helicase
MSMAL_RS09135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS09175	COG0210	DNA helicase
MSMAL_RS09305	COG3063	Type IV pilus biogenesis stability protein PilW
MSMAL_RS09315	COG3291	Pkd domain containing protein
MSMAL_RS09325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MSMAL_RS09335	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAL_RS09335	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSMAL_RS09355	COG0531	amino acid
MSMAL_RS09360	COG0426	domain, Protein
MSMAL_RS09370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSMAL_RS09395	COG0534	Mate efflux family protein
MSMAL_RS09400	COG1846	Transcriptional regulator
MSMAL_RS09420	COG1073	alpha beta
MSMAL_RS09425	COG0697	spore germination
MSMAL_RS09430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAL_RS09435	COG0392	lysyltransferase activity
MSMAL_RS09435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MSMAL_RS09445	COG0534	Mate efflux family protein
MSMAL_RS09450	COG2205	protein histidine kinase activity
MSMAL_RS09450	COG2202	Pas domain
MSMAL_RS09455	COG0784	Response regulator, receiver
MSMAL_RS09460	COG0826	peptidase U32
MSMAL_RS09465	COG0640	Transcriptional regulator
MSMAL_RS09485	COG1151	hydroxylamine reductase activity
MSMAL_RS09555	COG0300	oxidoreductase activity
MSMAL_RS09575	COG0306	phosphate transporter
MSMAL_RS09590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MSMAL_RS09595	COG0352	thiamine-phosphate diphosphorylase activity
MSMAL_RS09645	COG3629	intracellular signal transduction
MSMAL_RS09645	COG3903	Transcriptional regulator
MSMAL_RS09715	COG3264	Mechanosensitive ion channel
MSMAL_RS09715	COG1511	domain protein
MSMAL_RS09730	COG0668	transmembrane transport
MSMAL_RS09735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MSMAL_RS09745	COG2221	Nitrite and sulphite reductase 4Fe-4S
MSMAL_RS09785	COG2814	Major facilitator Superfamily
MSMAL_RS09800	COG1253	flavin adenine dinucleotide binding
MSMAL_RS09815	COG1836	PFAM Integral membrane protein DUF92
MSMAL_RS09820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAL_RS09850	COG1408	metallophosphoesterase
MSMAL_RS09880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSMAL_RS09885	COG0556	nucleotide-excision repair
MSMAL_RS09890	COG0322	excinuclease ABC activity
MSMAL_RS09895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MSMAL_RS09950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSMAL_RS09955	COG1061	Type III restriction enzyme res subunit
MSMAL_RS10045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAL_RS10055	COG0747	negative chemotaxis
MSMAL_RS10060	COG4608	Belongs to the ABC transporter superfamily
MSMAL_RS10070	COG1301	dicarboxylic acid transport
MSMAL_RS10080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAL_RS10090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAL_RS10105	COG0562	UDP-galactopyranose mutase
MSMAL_RS10120	COG5012	cobalamin binding
MSMAL_RS10175	COG0148	phosphopyruvate hydratase activity
MSMAL_RS10195	COG1136	(ABC) transporter
MSMAL_RS10215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MSMAL_RS10235	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSMAL_RS10240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSMAL_RS10245	COG0134	indole-3-glycerol-phosphate synthase activity
MSMAL_RS10250	COG0133	tryptophan synthase activity
MSMAL_RS10255	COG0159	tryptophan synthase activity
MSMAL_RS10260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSMAL_RS10265	COG0135	phosphoribosylanthranilate isomerase activity
MSMAL_RS10275	COG0512	Glutamine amidotransferase of anthranilate synthase
MSMAL_RS10275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSMAL_RS10340	COG0367	asparagine synthase
MSMAL_RS10385	COG1741	Belongs to the pirin family
MSMAL_RS10405	COG0746	molybdenum cofactor guanylyltransferase activity
MSMAL_RS10415	COG2003	Belongs to the UPF0758 family
MSMAL_RS10445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAL_RS10450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSMAL_RS10460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSMAL_RS10485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSMAL_RS10490	COG1254	Belongs to the acylphosphatase family
MSMAL_RS10525	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSMAL_RS10545	COG0628	permease
MSMAL_RS10560	COG2195	Cleaves the N-terminal amino acid of tripeptides
MSMAL_RS10590	COG0494	nUDIX hydrolase
MSMAL_RS10605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAL_RS10640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAL_RS10650	COG2095	MarC family integral membrane protein
MSMAL_RS10690	COG0574	Belongs to the PEP-utilizing enzyme family
MSMAL_RS10690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSMAL_RS10695	COG0590	tRNA wobble adenosine to inosine editing
MSMAL_RS10715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MSMAL_RS10730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSMAL_RS10735	COG1793	dna ligase
MSMAL_RS10740	COG0460	homoserine dehydrogenase
MSMAL_RS10780	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAL_RS10785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAL_RS10855	COG1373	ATPase (AAA superfamily
MSMAL_RS10885	COG1032	radical SAM domain protein
MSMAL_RS11000	COG0714	Associated with various cellular activities
MSMAL_RS11010	COG1136	(ABC) transporter
MSMAL_RS11025	COG1115	amino acid carrier protein
MSMAL_RS11040	COG0456	acetyltransferase
MSMAL_RS11045	COG0456	acetyltransferase
MSMAL_RS11050	COG0864	Transcriptional regulator
MSMAL_RS11055	COG1047	Peptidyl-prolyl cis-trans
MSMAL_RS11075	COG0826	peptidase U32
MSMAL_RS11080	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSMAL_RS11100	COG0436	Aminotransferase
MSMAL_RS11115	COG2414	aldehyde ferredoxin oxidoreductase
MSMAL_RS11150	COG0598	Magnesium transport protein CorA
MSMAL_RS11160	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSMAL_RS11165	COG0668	transmembrane transport
MSMAL_RS11195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSMAL_RS11210	COG0577	efflux transmembrane transporter activity
MSMAL_RS11230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MSMAL_RS11290	COG5012	cobalamin binding
MSMAL_RS11325	COG1215	transferase activity, transferring glycosyl groups
MSMAL_RS11335	COG0723	plastoquinol--plastocyanin reductase activity
MSMAL_RS11335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MSMAL_RS11350	COG2239	Acts as a magnesium transporter
MSMAL_RS11355	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAL_RS11375	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAL_RS11425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MSMAL_RS11455	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MSMAL_RS11460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSMAL_RS11465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSMAL_RS11485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSMAL_RS11500	COG5012	cobalamin binding
MSMAL_RS11515	COG5012	cobalamin binding
MSMAL_RS11560	COG3613	nucleoside 2-deoxyribosyltransferase
MSMAL_RS11565	COG0826	peptidase U32
MSMAL_RS11590	COG0107	imidazoleglycerol-phosphate synthase activity
MSMAL_RS11600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSMAL_RS11620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSMAL_RS11620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSMAL_RS11625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSMAL_RS11630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSMAL_RS11715	COG0535	radical SAM domain protein
MSMAL_RS11725	COG1522	sequence-specific DNA binding
MSMAL_RS11730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSMAL_RS11730	COG1648	precorrin-2 dehydrogenase activity
MSMAL_RS11735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSMAL_RS11740	COG0113	porphobilinogen synthase activity
MSMAL_RS11750	COG0181	hydroxymethylbilane synthase activity
MSMAL_RS11755	COG0167	dihydroorotate dehydrogenase activity
MSMAL_RS11765	COG0179	Fumarylacetoacetate (FAA) hydrolase
MSMAL_RS11775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MSMAL_RS11795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MSMAL_RS11810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSMAL_RS11815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSMAL_RS11835	COG0052	Belongs to the universal ribosomal protein uS2 family
MSMAL_RS11840	COG1355	regulation of microtubule-based process
MSMAL_RS11845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MSMAL_RS11855	COG1304	FMN binding
MSMAL_RS11865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSMAL_RS11870	COG0142	geranyltranstransferase activity
MSMAL_RS11890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSMAL_RS11890	COG0574	Belongs to the PEP-utilizing enzyme family
MSMAL_RS11915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS12025	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAL_RS12035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSMAL_RS12040	COG0459	protein refolding
MSMAL_RS12075	COG1592	Rubrerythrin
MSMAL_RS12095	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAL_RS12125	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MSMAL_RS12165	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MSMAL_RS12170	COG2255	four-way junction helicase activity
MSMAL_RS12195	COG5016	pyruvate
MSMAL_RS12195	COG0511	ligase activity, forming carbon-carbon bonds
MSMAL_RS12200	COG0439	Biotin carboxylase
MSMAL_RS12205	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSMAL_RS12205	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSMAL_RS12240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MSMAL_RS12255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAL_RS12265	COG0247	lactate metabolic process
MSMAL_RS12265	COG2181	nitrate reductase activity
MSMAL_RS12290	COG2081	HI0933 family
MSMAL_RS12315	COG1144	Oxidoreductase
MSMAL_RS12320	COG4608	Belongs to the ABC transporter superfamily
MSMAL_RS12325	COG0444	Belongs to the ABC transporter superfamily
MSMAL_RS12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAL_RS12340	COG0747	negative chemotaxis
MSMAL_RS12395	COG0163	prenyltransferase activity
MSMAL_RS12405	COG1078	dGTPase activity
MSMAL_RS12410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MSMAL_RS12430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSMAL_RS12440	COG2264	protein methyltransferase activity
MSMAL_RS12445	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAL_RS12490	COG0668	transmembrane transport
MSMAL_RS12500	COG3119	arylsulfatase activity
MSMAL_RS12505	COG0641	radical SAM
MSMAL_RS12510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSMAL_RS12510	COG1796	DNA polymerase
MSMAL_RS12515	COG1793	dna ligase
MSMAL_RS12565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAL_RS12590	COG0424	maF-like protein
MSMAL_RS12595	COG0215	cysteine-tRNA ligase activity
MSMAL_RS12620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSMAL_RS12625	COG1201	RNA secondary structure unwinding
MSMAL_RS12655	COG3339	Conserved Protein
MSMAL_RS12675	COG1247	-acetyltransferase
MSMAL_RS12695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAL_RS12700	COG0697	spore germination
MSMAL_RS12725	COG1739	Uncharacterized protein family UPF0029
MSMAL_RS12735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSMAL_RS12745	COG0765	amino acid transport
MSMAL_RS12755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MSMAL_RS12785	COG0667	Aldo Keto reductase
MSMAL_RS12790	COG2226	methyltransferase
MSMAL_RS12795	COG0753	catalase activity
MSMAL_RS12795	COG0693	protein deglycase activity
MSMAL_RS12810	COG0822	iron-sulfur transferase activity
MSMAL_RS12815	COG1104	cysteine desulfurase activity
MSMAL_RS12820	COG2210	Belongs to the sulfur carrier protein TusA family
MSMAL_RS12825	COG0425	Belongs to the sulfur carrier protein TusA family
MSMAL_RS12830	COG0537	adenosine 5'-monophosphoramidase activity
MSMAL_RS12835	COG4095	Psort location CytoplasmicMembrane, score
MSMAL_RS12855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSMAL_RS12870	COG0039	L-malate dehydrogenase activity
MSMAL_RS12930	COG1229	Formylmethanofuran dehydrogenase subunit A
MSMAL_RS12935	COG0243	molybdopterin cofactor binding
MSMAL_RS12955	COG3291	Pkd domain containing protein
MSMAL_RS13005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAL_RS13010	COG1122	ATPase activity
MSMAL_RS13050	COG0417	DNA replication proofreading
MSMAL_RS13055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSMAL_RS13060	COG0573	inorganic phosphate transmembrane transporter activity
MSMAL_RS13065	COG0581	inorganic phosphate transmembrane transporter activity
MSMAL_RS13070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSMAL_RS13075	COG0704	Plays a role in the regulation of phosphate uptake
MSMAL_RS13080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MSMAL_RS13085	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAL_RS13120	COG0316	Belongs to the HesB IscA family
MSMAL_RS13135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSMAL_RS13180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAL_RS13185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSMAL_RS13205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSMAL_RS13230	COG1522	sequence-specific DNA binding
MSMAL_RS13235	COG0436	Aminotransferase
MSMAL_RS13275	COG5012	cobalamin binding
MSMAL_RS13310	COG5012	cobalamin binding
MSMAL_RS13320	COG1372	Participates in initiation and elongation during chromosome replication
MSMAL_RS13320	COG0719	Fe-S assembly protein
MSMAL_RS13325	COG0396	ATPase activity
MSMAL_RS13330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAL_RS13345	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSMAL_RS13350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSMAL_RS13355	COG0124	histidyl-tRNA synthetase
MSMAL_RS13385	COG1120	ATPase activity
MSMAL_RS13390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSMAL_RS13400	COG0157	Belongs to the NadC ModD family
MSMAL_RS13405	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MSMAL_RS13410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSMAL_RS13420	COG0109	protoheme IX farnesyltransferase activity
MSMAL_RS13430	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSMAL_RS13440	COG1458	PINc domain ribonuclease
MSMAL_RS13455	COG0390	transport system, permease component
MSMAL_RS13460	COG1132	(ABC) transporter
MSMAL_RS13465	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSMAL_RS13470	COG0284	orotidine-5'-phosphate decarboxylase activity
MSMAL_RS13505	COG1342	Belongs to the UPF0251 family
MSMAL_RS13560	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS13575	COG0297	glycogen (starch) synthase activity
MSMAL_RS13590	COG2348	transferase activity, transferring amino-acyl groups
MSMAL_RS13675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSMAL_RS13680	COG0088	Forms part of the polypeptide exit tunnel
MSMAL_RS13685	COG0089	rRNA binding
MSMAL_RS13695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSMAL_RS13705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSMAL_RS13710	COG0255	Belongs to the universal ribosomal protein uL29 family
MSMAL_RS13725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSMAL_RS13730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MSMAL_RS13740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MSMAL_RS13750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSMAL_RS13755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MSMAL_RS13775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSMAL_RS13785	COG0200	Binds to the 23S rRNA
MSMAL_RS13795	COG0563	adenylate kinase activity
MSMAL_RS13800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSMAL_RS13810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAL_RS13825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MSMAL_RS13835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSMAL_RS13840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSMAL_RS13885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSMAL_RS13900	COG0298	carbon dioxide binding
MSMAL_RS13945	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MSMAL_RS13960	COG2205	protein histidine kinase activity
MSMAL_RS13960	COG2202	Pas domain
MSMAL_RS13970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAL_RS13970	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAL_RS13975	COG1494	fructose-1,6-bisphosphatase
MSMAL_RS13980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSMAL_RS14005	COG1592	Rubrerythrin
MSMAL_RS14040	COG0420	3'-5' exonuclease activity
MSMAL_RS14045	COG1196	nuclear chromosome segregation
MSMAL_RS14050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSMAL_RS14065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MSMAL_RS14070	COG0315	cyclic pyranopterin monophosphate synthase activity
MSMAL_RS14080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSMAL_RS14080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSMAL_RS14130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MSMAL_RS14135	COG1215	transferase activity, transferring glycosyl groups
MSMAL_RS14140	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS14155	COG0463	Glycosyl transferase, family 2
MSMAL_RS14185	COG0785	Cytochrome C biogenesis protein
MSMAL_RS14195	COG2226	methyltransferase
MSMAL_RS14200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSMAL_RS14225	COG0701	Predicted permease
MSMAL_RS14300	COG0051	transcription antitermination factor activity, RNA binding
MSMAL_RS14305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSMAL_RS14310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MSMAL_RS14315	COG0049	tRNA binding
MSMAL_RS14335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSMAL_RS14340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSMAL_RS14345	COG0085	RNA polymerase activity
MSMAL_RS14350	COG0085	RNA polymerase activity
MSMAL_RS14400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSMAL_RS14405	COG0402	S-adenosylhomocysteine deaminase activity
MSMAL_RS14410	COG1418	mRNA catabolic process
MSMAL_RS14425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MSMAL_RS14445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSMAL_RS14450	COG0587	DNA-directed DNA polymerase activity
MSMAL_RS14490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MSMAL_RS14500	COG3875	lactate racemase activity
MSMAL_RS14505	COG3875	lactate racemase activity
MSMAL_RS14510	COG4145	pantothenate transmembrane transporter activity
MSMAL_RS14515	COG0252	asparaginase activity
MSMAL_RS14520	COG0165	Argininosuccinate lyase
MSMAL_RS14560	COG0298	carbon dioxide binding
MSMAL_RS14565	COG0409	Hydrogenase expression formation protein
MSMAL_RS14570	COG0375	protein maturation
MSMAL_RS14575	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSMAL_RS14580	COG0309	Hydrogenase expression formation protein (HypE)
MSMAL_RS14585	COG2111	Na H antiporter
MSMAL_RS14585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSMAL_RS14590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSMAL_RS14595	COG3260	NADH ubiquinone oxidoreductase 20
MSMAL_RS14605	COG0649	NAD binding
MSMAL_RS14610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MSMAL_RS14620	COG2608	mercury ion transmembrane transporter activity
MSMAL_RS14630	COG2217	Heavy metal translocating P-type atpase
MSMAL_RS14640	COG4895	conserved protein (DUF2196)
MSMAL_RS14655	COG2076	Multidrug Resistance protein
MSMAL_RS14690	COG0028	Belongs to the TPP enzyme family
MSMAL_RS14695	COG1012	belongs to the aldehyde dehydrogenase family
MSMAL_RS14735	COG0546	phosphoglycolate phosphatase activity
MSMAL_RS14785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSMAL_RS14795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSMAL_RS14815	COG0481	GTPase activity
MSMAL_RS14830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSMAL_RS14835	COG0436	Aminotransferase
MSMAL_RS14845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAL_RS14855	COG0140	phosphoribosyl-ATP diphosphatase activity
MSMAL_RS14855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSMAL_RS14890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MSMAL_RS14940	COG1122	ATPase activity
MSMAL_RS14945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAL_RS14960	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAL_RS14980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSMAL_RS14990	COG4555	ABC transporter
MSMAL_RS14995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSMAL_RS15090	COG0187	DNA topoisomerase II activity
MSMAL_RS15095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MSMAL_RS15125	COG0412	Dienelactone hydrolase
MSMAL_RS15135	COG5012	cobalamin binding
MSMAL_RS15140	COG0671	phosphoesterase, PA-phosphatase related
MSMAL_RS15150	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MSMAL_RS15155	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MSMAL_RS15255	COG1131	(ABC) transporter
MSMAL_RS15270	COG0601	transmembrane transport
MSMAL_RS15280	COG0747	negative chemotaxis
MSMAL_RS15295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSMAL_RS15300	COG0105	UTP biosynthetic process
MSMAL_RS15395	COG1007	ATP synthesis coupled electron transport
MSMAL_RS15400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAL_RS15410	COG0713	ATP synthesis coupled electron transport
MSMAL_RS15430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSMAL_RS15435	COG0649	NAD binding
MSMAL_RS15440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAL_RS15445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAL_RS15465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSMAL_RS15475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSMAL_RS15505	COG0569	domain protein
MSMAL_RS15510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MSMAL_RS15520	COG0484	heat shock protein binding
MSMAL_RS15525	COG0443	Heat shock 70 kDa protein
MSMAL_RS15530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MSMAL_RS15580	COG0745	RESPONSE REGULATOR receiver
MSMAL_RS15585	COG0301	tRNA thio-modification
MSMAL_RS15590	COG2205	protein histidine kinase activity
MSMAL_RS15595	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSMAL_RS15605	COG0589	response to stress
MSMAL_RS15635	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MSMAL_RS15655	COG3174	membrane
MSMAL_RS15690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSMAL_RS15695	COG2890	protein-(glutamine-N5) methyltransferase activity
MSMAL_RS15700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAL_RS15705	COG2816	NAD+ diphosphatase activity
MSMAL_RS15770	COG0753	catalase activity
MSMAL_RS15780	COG1162	GTPase activity
MSMAL_RS15840	COG0601	transmembrane transport
MSMAL_RS15845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAL_RS15850	COG0444	Belongs to the ABC transporter superfamily
MSMAL_RS15855	COG4608	Belongs to the ABC transporter superfamily
MSMAL_RS15865	COG1321	iron dependent repressor
MSMAL_RS15880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSMAL_RS15880	COG1918	ferrous iron import across plasma membrane
MSMAL_RS15915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSMAL_RS15920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSMAL_RS15925	COG0805	protein transport
MSMAL_RS15930	COG0805	protein transport
MSMAL_RS15955	COG0697	spore germination
MSMAL_RS15980	COG1945	arginine decarboxylase activity
MSMAL_RS15985	COG0145	ligase activity
MSMAL_RS16005	COG1451	nucleotide metabolic process
MSMAL_RS16040	COG2361	Protein of unknown function DUF86
MSMAL_RS16060	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MSMAL_RS16065	COG1111	helicase
MSMAL_RS16065	COG1205	dead DEAH box helicase
MSMAL_RS16075	COG1704	LemA family
MSMAL_RS16100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSMAL_RS16120	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAL_RS16125	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAL_RS16150	COG2205	protein histidine kinase activity
MSMAL_RS16165	COG0281	malic enzyme
MSMAL_RS16175	COG4106	trans-aconitate 2-methyltransferase activity
MSMAL_RS16215	COG1830	Aldolase
MSMAL_RS16235	COG0523	cobalamin synthesis protein
MSMAL_RS16260	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MSMAL_RS16265	COG1691	(AIR) carboxylase
MSMAL_RS16270	COG0667	Aldo Keto reductase
MSMAL_RS16290	COG0528	UMP kinase activity
MSMAL_RS16300	COG0577	efflux transmembrane transporter activity
MSMAL_RS16300	COG1136	(ABC) transporter
MSMAL_RS16305	COG1136	(ABC) transporter
MSMAL_RS16310	COG0456	acetyltransferase
MSMAL_RS16315	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSMAL_RS16360	COG0428	transporter
MSMAL_RS16445	COG1733	regulation of RNA biosynthetic process
MSMAL_RS16470	COG2249	NAD(P)H dehydrogenase (quinone) activity
MSMAL_RS16475	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAL_RS16485	COG3842	ATPase activity
MSMAL_RS16530	COG0243	molybdopterin cofactor binding
MSMAL_RS16545	COG1229	Formylmethanofuran dehydrogenase subunit A
MSMAL_RS16560	COG3842	ATPase activity
MSMAL_RS16565	COG4662	Binding-protein-dependent transport system inner membrane component
MSMAL_RS16630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSMAL_RS16675	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSMAL_RS16695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSMAL_RS16700	COG0235	Class ii aldolase
MSMAL_RS16715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSMAL_RS16720	COG0714	Associated with various cellular activities
MSMAL_RS16725	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MSMAL_RS16740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MSMAL_RS16745	COG0372	Belongs to the citrate synthase family
MSMAL_RS16770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSMAL_RS16775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSMAL_RS16780	COG1606	tRNA processing
MSMAL_RS16785	COG1247	-acetyltransferase
MSMAL_RS16800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSMAL_RS16855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSMAL_RS16860	COG0131	Imidazoleglycerol-phosphate dehydratase
MSMAL_RS16865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSMAL_RS16870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSMAL_RS16875	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSMAL_RS16905	COG0024	Methionine aminopeptidase
MSMAL_RS16925	COG0101	tRNA pseudouridine synthase activity
MSMAL_RS16950	COG0066	3-isopropylmalate dehydratase activity
MSMAL_RS16955	COG0473	3-isopropylmalate dehydrogenase activity
MSMAL_RS16965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS16995	COG4279	zinc finger
MSMAL_RS17000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSMAL_RS17005	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSMAL_RS17020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS17025	COG0535	radical SAM domain protein
MSMAL_RS17070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAL_RS17095	COG0589	response to stress
MSMAL_RS17100	COG0589	response to stress
MSMAL_RS17130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAL_RS17130	COG0731	radical SAM domain protein
MSMAL_RS17140	COG1342	Belongs to the UPF0251 family
MSMAL_RS17155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSMAL_RS17160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MSMAL_RS17175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSMAL_RS17185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAL_RS17190	COG5012	cobalamin binding
MSMAL_RS17205	COG0531	amino acid
MSMAL_RS17250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSMAL_RS17255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSMAL_RS17270	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MSMAL_RS17270	COG0778	Nitroreductase
MSMAL_RS17280	COG0071	Belongs to the small heat shock protein (HSP20) family
MSMAL_RS17285	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSMAL_RS17295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSMAL_RS17345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSMAL_RS17350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSMAL_RS17360	COG1183	phosphatidylcholine synthase activity
MSMAL_RS17365	COG0688	phosphatidylethanolamine metabolic process
MSMAL_RS17410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MSMAL_RS17415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSMAL_RS17420	COG1584	GPR1 FUN34 yaaH family protein
MSMAL_RS17440	COG0423	glycine-tRNA ligase activity
MSMAL_RS17445	COG0322	excinuclease ABC activity
MSMAL_RS17465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSMAL_RS17480	COG0443	Heat shock 70 kDa protein
MSMAL_RS17500	COG0459	protein refolding
MSMAL_RS17520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MSMAL_RS17525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSMAL_RS17540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSMAL_RS17545	COG1260	myo-inositol-1-phosphate synthase
MSMAL_RS17565	COG0602	queuosine metabolic process
MSMAL_RS17570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSMAL_RS17590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSMAL_RS17605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS17610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS17615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS17620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAL_RS17645	COG0482	sulfurtransferase activity
MSMAL_RS17660	COG0018	arginyl-trna synthetase
MSMAL_RS17700	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAL_RS17705	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSMAL_RS17730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MSMAL_RS17735	COG1121	(ABC) transporter
MSMAL_RS17750	COG2610	gluconate transmembrane transporter activity
MSMAL_RS17760	COG0840	transmembrane signaling receptor activity
MSMAL_RS17765	COG0784	Response regulator, receiver
MSMAL_RS17770	COG2201	protein-glutamate methylesterase activity
MSMAL_RS17775	COG2201	protein-glutamate methylesterase activity
MSMAL_RS17780	COG0643	Histidine kinase
MSMAL_RS17780	COG2198	Histidine kinase
MSMAL_RS17785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSMAL_RS17795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSMAL_RS17800	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSMAL_RS17820	COG0076	glutamate decarboxylase activity
MSMAL_RS17845	COG3391	amine dehydrogenase activity
MSMAL_RS17860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAL_RS17870	COG1401	restriction endodeoxyribonuclease activity
MSMAL_RS17950	COG0438	transferase activity, transferring glycosyl groups
MSMAL_RS18055	COG1742	UPF0060 membrane protein
MSMAL_RS18125	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAL_RS18155	COG0137	argininosuccinate synthase activity
MSMAL_RS18170	COG3344	reverse transcriptase
MSMAL_RS18200	COG4251	negative regulation of phosphorylation
MSMAL_RS18310	COG1773	rubredoxin
MSMAL_RS18315	COG2205	protein histidine kinase activity
MSMAL_RS18470	COG0589	response to stress