locus-tag	class	description
MSMAP_RS00060	COG0516	GMP reductase activity
MSMAP_RS00060	COG0517	IMP dehydrogenase activity
MSMAP_RS00065	COG0516	GMP reductase activity
MSMAP_RS00095	COG0430	RNA-3'-phosphate cyclase activity
MSMAP_RS00105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAP_RS00125	COG0456	acetyltransferase
MSMAP_RS00135	COG0277	FAD linked oxidase domain protein
MSMAP_RS00140	COG0247	lactate metabolic process
MSMAP_RS00165	COG0084	hydrolase, TatD family'
MSMAP_RS00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAP_RS00220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAP_RS00225	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSMAP_RS00230	COG2022	thiamine diphosphate biosynthetic process
MSMAP_RS00235	COG2890	protein-(glutamine-N5) methyltransferase activity
MSMAP_RS00245	COG0287	Prephenate dehydrogenase
MSMAP_RS00245	COG1605	Chorismate mutase
MSMAP_RS00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSMAP_RS00255	COG0710	3-dehydroquinate dehydratase activity
MSMAP_RS00260	COG1465	3-dehydroquinate synthase
MSMAP_RS00265	COG1830	Aldolase
MSMAP_RS00270	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAP_RS00270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAP_RS00275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSMAP_RS00325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS00360	COG1850	ribulose-bisphosphate carboxylase activity
MSMAP_RS00365	COG0009	L-threonylcarbamoyladenylate synthase
MSMAP_RS00415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSMAP_RS00420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSMAP_RS00425	COG0501	Belongs to the peptidase M48B family
MSMAP_RS00435	COG1715	Restriction endonuclease
MSMAP_RS00440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MSMAP_RS00455	COG2264	protein methyltransferase activity
MSMAP_RS00470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAP_RS00475	COG0154	amidase activity
MSMAP_RS00480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAP_RS00485	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSMAP_RS00500	COG1469	GTP cyclohydrolase I activity
MSMAP_RS00510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSMAP_RS00520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAP_RS00520	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAP_RS00535	COG0514	ATP-dependent DNA helicase (RecQ)
MSMAP_RS00555	COG0540	Belongs to the ATCase OTCase family
MSMAP_RS00560	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MSMAP_RS00610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSMAP_RS00615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSMAP_RS00695	COG0463	Glycosyl transferase, family 2
MSMAP_RS00720	COG1216	Glycosyl transferase, family 2
MSMAP_RS00720	COG1442	glycosyl transferase family 8
MSMAP_RS00735	COG2244	polysaccharide biosynthetic process
MSMAP_RS00750	COG1091	dTDP-4-dehydrorhamnose reductase activity
MSMAP_RS00785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSMAP_RS00800	COG1254	Belongs to the acylphosphatase family
MSMAP_RS00830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MSMAP_RS00835	COG0673	inositol 2-dehydrogenase activity
MSMAP_RS00885	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS00890	COG0297	glycogen (starch) synthase activity
MSMAP_RS00895	COG1216	Glycosyl transferase, family 2
MSMAP_RS00900	COG0463	Glycosyl transferase, family 2
MSMAP_RS00905	COG0463	Glycosyl transferase, family 2
MSMAP_RS00905	COG1216	Glycosyl transferase, family 2
MSMAP_RS00910	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS00910	COG0297	glycogen (starch) synthase activity
MSMAP_RS00915	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS00935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSMAP_RS00940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSMAP_RS00945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MSMAP_RS00970	COG0463	Glycosyl transferase, family 2
MSMAP_RS00975	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS00995	COG0673	inositol 2-dehydrogenase activity
MSMAP_RS01000	COG1216	Glycosyl transferase, family 2
MSMAP_RS01000	COG1442	glycosyl transferase family 8
MSMAP_RS01035	COG1891	lyase activity
MSMAP_RS01040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSMAP_RS01050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSMAP_RS01070	COG3830	Belongs to the UPF0237 family
MSMAP_RS01070	COG0560	Phosphoserine phosphatase
MSMAP_RS01090	COG0109	protoheme IX farnesyltransferase activity
MSMAP_RS01095	COG0343	queuine tRNA-ribosyltransferase activity
MSMAP_RS01115	COG0459	protein refolding
MSMAP_RS01135	COG4251	negative regulation of phosphorylation
MSMAP_RS01140	COG4251	negative regulation of phosphorylation
MSMAP_RS01145	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAP_RS01155	COG0719	Fe-S assembly protein
MSMAP_RS01155	COG1372	Participates in initiation and elongation during chromosome replication
MSMAP_RS01160	COG0396	ATPase activity
MSMAP_RS01185	COG0012	GTP binding
MSMAP_RS01225	COG1584	GPR1 FUN34 yaaH family protein
MSMAP_RS01235	COG5012	cobalamin binding
MSMAP_RS01245	COG0523	cobalamin synthesis protein
MSMAP_RS01260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAP_RS01265	COG0784	Response regulator, receiver
MSMAP_RS01285	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MSMAP_RS01285	COG3261	NADH dehydrogenase
MSMAP_RS01290	COG0651	ATP synthesis coupled electron transport
MSMAP_RS01305	COG0651	ATP synthesis coupled electron transport
MSMAP_RS01315	COG4152	abc transporter atp-binding protein
MSMAP_RS01325	COG5012	cobalamin binding
MSMAP_RS01360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MSMAP_RS01370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAP_RS01375	COG0303	'Molybdopterin
MSMAP_RS01400	COG0640	Transcriptional regulator
MSMAP_RS01405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAP_RS01410	COG1122	ATPase activity
MSMAP_RS01415	COG1122	ATPase activity
MSMAP_RS01420	COG1268	BioY protein
MSMAP_RS01430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSMAP_RS01440	COG1918	ferrous iron import across plasma membrane
MSMAP_RS01440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSMAP_RS01455	COG1196	nuclear chromosome segregation
MSMAP_RS01465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSMAP_RS01485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSMAP_RS01530	COG0535	radical SAM domain protein
MSMAP_RS01540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSMAP_RS01545	COG0081	regulation of translation
MSMAP_RS01550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSMAP_RS01565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSMAP_RS01580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS01595	COG0473	3-isopropylmalate dehydrogenase activity
MSMAP_RS01600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAP_RS01655	COG0489	protein tyrosine kinase activity
MSMAP_RS01660	COG1342	Belongs to the UPF0251 family
MSMAP_RS01675	COG0489	protein tyrosine kinase activity
MSMAP_RS01700	COG2048	Heterodisulfide reductase, subunit B
MSMAP_RS01730	COG0024	Methionine aminopeptidase
MSMAP_RS01775	COG0067	glutamate synthase
MSMAP_RS01790	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MSMAP_RS01820	COG0347	Belongs to the P(II) protein family
MSMAP_RS01825	COG0004	ammonium transporteR
MSMAP_RS01850	COG1136	(ABC) transporter
MSMAP_RS01860	COG0577	efflux transmembrane transporter activity
MSMAP_RS01865	COG1136	(ABC) transporter
MSMAP_RS01875	COG2205	protein histidine kinase activity
MSMAP_RS01880	COG0577	efflux transmembrane transporter activity
MSMAP_RS01895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MSMAP_RS01900	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MSMAP_RS01910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MSMAP_RS01940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAP_RS01945	COG4962	Type ii secretion system protein e
MSMAP_RS01960	COG0456	acetyltransferase
MSMAP_RS01965	COG1509	lysine 2,3-aminomutase activity
MSMAP_RS01970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSMAP_RS01970	COG4651	solute:proton antiporter activity
MSMAP_RS02000	COG1476	TRANSCRIPTIONal
MSMAP_RS02020	COG0010	Belongs to the arginase family
MSMAP_RS02035	COG0494	nUDIX hydrolase
MSMAP_RS02040	COG5549	protein import
MSMAP_RS02040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSMAP_RS02080	COG1122	ATPase activity
MSMAP_RS02085	COG2217	Heavy metal translocating P-type atpase
MSMAP_RS02105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSMAP_RS02115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSMAP_RS02125	COG1584	GPR1 FUN34 yaaH family protein
MSMAP_RS02130	COG0500	methyltransferase
MSMAP_RS02165	COG0138	bifunctional purine biosynthesis protein purh
MSMAP_RS02170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAP_RS02175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAP_RS02185	COG0310	cobalt ion transport
MSMAP_RS02190	COG2226	methyltransferase
MSMAP_RS02210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAP_RS02215	COG1122	ATPase activity
MSMAP_RS02220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSMAP_RS02250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MSMAP_RS02255	COG0183	Belongs to the thiolase family
MSMAP_RS02275	COG0640	Transcriptional regulator
MSMAP_RS02290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSMAP_RS02290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSMAP_RS02295	COG0616	signal peptide processing
MSMAP_RS02300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSMAP_RS02350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSMAP_RS02355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS02360	COG0321	lipoyl(octanoyl) transferase activity
MSMAP_RS02360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSMAP_RS02375	COG2155	Conserved Protein
MSMAP_RS02380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSMAP_RS02415	COG0864	Transcriptional regulator
MSMAP_RS02420	COG0640	Transcriptional regulator
MSMAP_RS02425	COG1216	Glycosyl transferase, family 2
MSMAP_RS02455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAP_RS02485	COG0303	'Molybdopterin
MSMAP_RS02490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSMAP_RS02495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSMAP_RS02510	COG0517	IMP dehydrogenase activity
MSMAP_RS02520	COG0402	S-adenosylhomocysteine deaminase activity
MSMAP_RS02540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSMAP_RS02545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSMAP_RS02550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MSMAP_RS02555	COG0450	alkyl hydroperoxide reductase
MSMAP_RS02570	COG1983	PspC domain protein
MSMAP_RS02575	COG0552	protein localization to endoplasmic reticulum
MSMAP_RS02620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSMAP_RS02635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS02660	COG1461	Dihydroxyacetone kinase
MSMAP_RS02710	COG1269	ATP hydrolysis coupled proton transport
MSMAP_RS02735	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MSMAP_RS02740	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MSMAP_RS02775	COG4572	Cation transport regulator
MSMAP_RS02830	COG2144	transferase activity, transferring acyl groups
MSMAP_RS02840	COG1433	Dinitrogenase iron-molybdenum cofactor
MSMAP_RS02840	COG0535	radical SAM domain protein
MSMAP_RS02845	COG0720	synthase
MSMAP_RS02850	COG0602	queuosine metabolic process
MSMAP_RS02860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSMAP_RS02885	COG1063	alcohol dehydrogenase
MSMAP_RS02890	COG2226	methyltransferase
MSMAP_RS02895	COG0513	Belongs to the DEAD box helicase family
MSMAP_RS02920	COG0798	PFAM Bile acid sodium symporter
MSMAP_RS02965	COG1742	UPF0060 membrane protein
MSMAP_RS02975	COG0004	ammonium transporteR
MSMAP_RS02980	COG0347	Belongs to the P(II) protein family
MSMAP_RS02985	COG2226	methyltransferase
MSMAP_RS02995	COG3842	ATPase activity
MSMAP_RS03000	COG4149	molybdate abc transporter
MSMAP_RS03005	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAP_RS03030	COG0347	Belongs to the P(II) protein family
MSMAP_RS03040	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSMAP_RS03045	COG0644	oxidoreductase
MSMAP_RS03110	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSMAP_RS03115	COG0442	prolyl-tRNA aminoacylation
MSMAP_RS03150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSMAP_RS03155	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSMAP_RS03175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSMAP_RS03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSMAP_RS03185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSMAP_RS03285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSMAP_RS03300	COG1363	Peptidase, m42
MSMAP_RS03310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAP_RS03315	COG0028	Belongs to the TPP enzyme family
MSMAP_RS03320	COG0440	acetolactate synthase activity
MSMAP_RS03325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSMAP_RS03330	COG0778	Nitroreductase
MSMAP_RS03335	COG0864	Transcriptional regulator
MSMAP_RS03350	COG0493	'glutamate synthase
MSMAP_RS03360	COG0640	Transcriptional regulator
MSMAP_RS03365	COG2226	methyltransferase
MSMAP_RS03380	COG1215	transferase activity, transferring glycosyl groups
MSMAP_RS03405	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS03425	COG0066	3-isopropylmalate dehydratase activity
MSMAP_RS03440	COG0473	3-isopropylmalate dehydrogenase activity
MSMAP_RS03455	COG3527	Alpha-acetolactate decarboxylase
MSMAP_RS03460	COG0426	domain, Protein
MSMAP_RS03480	COG0431	NADPH-dependent FMN reductase
MSMAP_RS03490	COG2033	superoxide reductase activity
MSMAP_RS03520	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSMAP_RS03560	COG1331	Highly conserved protein containing a thioredoxin domain
MSMAP_RS03565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSMAP_RS03585	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAP_RS03595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSMAP_RS03600	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAP_RS03625	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSMAP_RS03640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSMAP_RS03645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSMAP_RS03675	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAP_RS03705	COG0371	Dehydrogenase
MSMAP_RS03720	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS03755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAP_RS03795	COG1518	maintenance of DNA repeat elements
MSMAP_RS03800	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MSMAP_RS03835	COG0557	exoribonuclease II activity
MSMAP_RS03865	COG1408	metallophosphoesterase
MSMAP_RS03875	COG0662	Cupin 2, conserved barrel domain protein
MSMAP_RS03915	COG0531	amino acid
MSMAP_RS03980	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSMAP_RS04000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSMAP_RS04025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAP_RS04080	COG0038	chloride channel
MSMAP_RS04085	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAP_RS04090	COG0280	phosphate acetyltransferase
MSMAP_RS04095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSMAP_RS04100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAP_RS04100	COG0045	succinate-CoA ligase (ADP-forming) activity
MSMAP_RS04100	COG1042	CoA-binding domain protein
MSMAP_RS04135	COG1573	uracil-dna glycosylase
MSMAP_RS04140	COG0126	phosphoglycerate kinase activity
MSMAP_RS04145	COG2078	PFAM AMMECR1 domain protein
MSMAP_RS04150	COG0071	Belongs to the small heat shock protein (HSP20) family
MSMAP_RS04165	COG0456	acetyltransferase
MSMAP_RS04170	COG3613	nucleoside 2-deoxyribosyltransferase
MSMAP_RS04180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSMAP_RS04185	COG0517	IMP dehydrogenase activity
MSMAP_RS04190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSMAP_RS04250	COG0310	cobalt ion transport
MSMAP_RS04265	COG1122	ATPase activity
MSMAP_RS04285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSMAP_RS04295	COG0561	phosphatase activity
MSMAP_RS04325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MSMAP_RS04330	COG0500	methyltransferase
MSMAP_RS04340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS04360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSMAP_RS04365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSMAP_RS04370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSMAP_RS04375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSMAP_RS04395	COG3118	belongs to the thioredoxin family
MSMAP_RS04420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAP_RS04425	COG0732	type I restriction modification DNA specificity domain
MSMAP_RS04430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAP_RS04445	COG1121	(ABC) transporter
MSMAP_RS04450	COG4581	dead DEAH box helicase
MSMAP_RS04455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MSMAP_RS04475	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSMAP_RS04475	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAP_RS04480	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSMAP_RS04575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAP_RS04615	COG5658	integral membrane protein
MSMAP_RS04630	COG1047	Peptidyl-prolyl cis-trans
MSMAP_RS04670	COG0714	Associated with various cellular activities
MSMAP_RS04680	COG0077	Prephenate dehydratase
MSMAP_RS04680	COG1605	Chorismate mutase
MSMAP_RS04740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAP_RS04745	COG1733	regulation of RNA biosynthetic process
MSMAP_RS04750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAP_RS04760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAP_RS04760	COG1042	CoA-binding domain protein
MSMAP_RS04760	COG0045	succinate-CoA ligase (ADP-forming) activity
MSMAP_RS04765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MSMAP_RS04785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAP_RS04810	COG1846	Transcriptional regulator
MSMAP_RS04820	COG0534	Mate efflux family protein
MSMAP_RS04830	COG0432	Pfam Uncharacterised protein family UPF0047
MSMAP_RS04835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSMAP_RS04845	COG0351	phosphomethylpyrimidine kinase
MSMAP_RS04855	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MSMAP_RS04875	COG3290	protein histidine kinase activity
MSMAP_RS04875	COG0840	transmembrane signaling receptor activity
MSMAP_RS04880	COG0835	chemotaxis
MSMAP_RS04890	COG2201	protein-glutamate methylesterase activity
MSMAP_RS04895	COG2201	protein-glutamate methylesterase activity
MSMAP_RS04900	COG2198	Histidine kinase
MSMAP_RS04900	COG0643	Histidine kinase
MSMAP_RS04900	COG2198	Histidine kinase
MSMAP_RS04900	COG0643	Histidine kinase
MSMAP_RS04905	COG1776	CheC inhibitor of MCP methylation
MSMAP_RS04910	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSMAP_RS05000	COG0535	radical SAM domain protein
MSMAP_RS05015	COG1234	tRNA 3'-trailer cleavage
MSMAP_RS05025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSMAP_RS05055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSMAP_RS05060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAP_RS05070	COG1125	glycine betaine transport
MSMAP_RS05070	COG0517	IMP dehydrogenase activity
MSMAP_RS05075	COG1174	glycine betaine transport
MSMAP_RS05130	COG1945	arginine decarboxylase activity
MSMAP_RS05140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSMAP_RS05145	COG0495	leucyl-tRNA aminoacylation
MSMAP_RS05150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MSMAP_RS05170	COG1401	restriction endodeoxyribonuclease activity
MSMAP_RS05215	COG0653	protein targeting
MSMAP_RS05220	COG0426	domain, Protein
MSMAP_RS05230	COG0129	dihydroxy-acid dehydratase activity
MSMAP_RS05240	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSMAP_RS05280	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAP_RS05285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAP_RS05290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MSMAP_RS05290	COG0617	tRNA 3'-terminal CCA addition
MSMAP_RS05290	COG0517	IMP dehydrogenase activity
MSMAP_RS05295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MSMAP_RS05305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSMAP_RS05310	COG0436	Aminotransferase
MSMAP_RS05320	COG0517	IMP dehydrogenase activity
MSMAP_RS05320	COG0516	GMP reductase activity
MSMAP_RS05345	COG0668	transmembrane transport
MSMAP_RS05360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSMAP_RS05415	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MSMAP_RS05530	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAP_RS05560	COG2361	Protein of unknown function DUF86
MSMAP_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
MSMAP_RS05590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSMAP_RS05595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSMAP_RS05625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MSMAP_RS05645	COG5012	cobalamin binding
MSMAP_RS05690	COG5310	Homospermidine synthase
MSMAP_RS05760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSMAP_RS05780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSMAP_RS05785	COG0151	Belongs to the GarS family
MSMAP_RS05795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSMAP_RS05810	COG1138	Cytochrome C-type biogenesis protein
MSMAP_RS05860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSMAP_RS05905	COG1067	ATP-dependent peptidase activity
MSMAP_RS05905	COG0470	DNA polymerase III
MSMAP_RS05910	COG0312	modulator of DNA gyrase
MSMAP_RS05915	COG0312	modulator of DNA gyrase
MSMAP_RS05920	COG0589	response to stress
MSMAP_RS05935	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAP_RS05955	COG0504	CTP synthase activity
MSMAP_RS05975	COG0534	Mate efflux family protein
MSMAP_RS05980	COG0585	pseudouridine synthase activity
MSMAP_RS06000	COG0822	iron-sulfur transferase activity
MSMAP_RS06015	COG1346	cytolysis
MSMAP_RS06075	COG1492	cobalamin metabolic process
MSMAP_RS06085	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSMAP_RS06145	COG3830	Belongs to the UPF0237 family
MSMAP_RS06150	COG2848	UPF0210 protein
MSMAP_RS06165	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MSMAP_RS06170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSMAP_RS06185	COG0017	Asparaginyl-tRNA synthetase
MSMAP_RS06190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSMAP_RS06195	COG0459	protein refolding
MSMAP_RS06205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSMAP_RS06270	COG1233	COG1233 Phytoene dehydrogenase and related
MSMAP_RS06280	COG0589	response to stress
MSMAP_RS06300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAP_RS06310	COG1012	belongs to the aldehyde dehydrogenase family
MSMAP_RS06315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MSMAP_RS06350	COG0517	IMP dehydrogenase activity
MSMAP_RS06350	COG4175	Glycine betaine
MSMAP_RS06355	COG0505	Belongs to the CarA family
MSMAP_RS06360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSMAP_RS06365	COG0137	argininosuccinate synthase activity
MSMAP_RS06380	COG0210	DNA helicase
MSMAP_RS06430	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAP_RS06440	COG2361	Protein of unknown function DUF86
MSMAP_RS06445	COG2226	methyltransferase
MSMAP_RS06455	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAP_RS06515	COG2226	methyltransferase
MSMAP_RS06535	COG2226	methyltransferase
MSMAP_RS06540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSMAP_RS06580	COG0444	Belongs to the ABC transporter superfamily
MSMAP_RS06585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAP_RS06590	COG0601	transmembrane transport
MSMAP_RS06675	COG2361	Protein of unknown function DUF86
MSMAP_RS06680	COG0653	protein targeting
MSMAP_RS06745	COG5012	cobalamin binding
MSMAP_RS06760	COG0562	UDP-galactopyranose mutase
MSMAP_RS06775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAP_RS06785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAP_RS06795	COG1301	dicarboxylic acid transport
MSMAP_RS06810	COG4608	Belongs to the ABC transporter superfamily
MSMAP_RS06815	COG0747	negative chemotaxis
MSMAP_RS06825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAP_RS06895	COG1846	Transcriptional regulator
MSMAP_RS06905	COG2226	methyltransferase
MSMAP_RS06910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSMAP_RS06920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSMAP_RS06925	COG2226	methyltransferase
MSMAP_RS06950	COG1061	Type III restriction enzyme res subunit
MSMAP_RS06955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSMAP_RS07020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MSMAP_RS07025	COG0322	excinuclease ABC activity
MSMAP_RS07030	COG0556	nucleotide-excision repair
MSMAP_RS07040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSMAP_RS07060	COG1408	metallophosphoesterase
MSMAP_RS07090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAP_RS07095	COG1836	PFAM Integral membrane protein DUF92
MSMAP_RS07110	COG1253	flavin adenine dinucleotide binding
MSMAP_RS07125	COG2814	Major facilitator Superfamily
MSMAP_RS07160	COG2221	Nitrite and sulphite reductase 4Fe-4S
MSMAP_RS07170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MSMAP_RS07175	COG0668	transmembrane transport
MSMAP_RS07185	COG3264	Mechanosensitive ion channel
MSMAP_RS07185	COG1511	domain protein
MSMAP_RS07230	COG0352	thiamine-phosphate diphosphorylase activity
MSMAP_RS07235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MSMAP_RS07255	COG0306	phosphate transporter
MSMAP_RS07265	COG0300	oxidoreductase activity
MSMAP_RS07330	COG1151	hydroxylamine reductase activity
MSMAP_RS07340	COG0826	peptidase U32
MSMAP_RS07345	COG0784	Response regulator, receiver
MSMAP_RS07350	COG2205	protein histidine kinase activity
MSMAP_RS07350	COG2202	Pas domain
MSMAP_RS07355	COG0534	Mate efflux family protein
MSMAP_RS07475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAP_RS07510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MSMAP_RS07510	COG0392	lysyltransferase activity
MSMAP_RS07525	COG0697	spore germination
MSMAP_RS07530	COG1073	alpha beta
MSMAP_RS07550	COG1846	Transcriptional regulator
MSMAP_RS07555	COG0534	Mate efflux family protein
MSMAP_RS07580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSMAP_RS07590	COG0426	domain, Protein
MSMAP_RS07595	COG0531	amino acid
MSMAP_RS07615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSMAP_RS07615	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAP_RS07625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MSMAP_RS07635	COG3291	Pkd domain containing protein
MSMAP_RS07645	COG3063	Type IV pilus biogenesis stability protein PilW
MSMAP_RS07725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MSMAP_RS07760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS07780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAP_RS07810	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAP_RS07840	COG1131	(ABC) transporter
MSMAP_RS07845	COG0501	Belongs to the peptidase M48B family
MSMAP_RS07895	COG0671	phosphoesterase, PA-phosphatase related
MSMAP_RS07940	COG2814	Major facilitator Superfamily
MSMAP_RS07955	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAP_RS07960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSMAP_RS07995	COG3485	protocatechuate 3,4-dioxygenase
MSMAP_RS08005	COG0058	SHG alpha-glucan phosphorylase activity
MSMAP_RS08020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSMAP_RS08045	COG2205	protein histidine kinase activity
MSMAP_RS08065	COG2205	protein histidine kinase activity
MSMAP_RS08075	COG1136	(ABC) transporter
MSMAP_RS08075	COG0577	efflux transmembrane transporter activity
MSMAP_RS08085	COG1136	(ABC) transporter
MSMAP_RS08130	COG4451	ribulose bisphosphate carboxylase, small
MSMAP_RS08130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSMAP_RS08140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MSMAP_RS08145	COG0626	cystathionine gamma-synthase activity
MSMAP_RS08150	COG0693	protein deglycase activity
MSMAP_RS08190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSMAP_RS08200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSMAP_RS08230	COG2326	polyphosphate kinase activity
MSMAP_RS08245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MSMAP_RS08265	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAP_RS08295	COG0658	competence protein
MSMAP_RS08295	COG2333	competence protein COMEC
MSMAP_RS08335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MSMAP_RS08345	COG2264	protein methyltransferase activity
MSMAP_RS08360	COG0110	maltose O-acetyltransferase activity
MSMAP_RS08390	COG1064	alcohol dehydrogenase
MSMAP_RS08400	COG0297	glycogen (starch) synthase activity
MSMAP_RS08420	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MSMAP_RS08425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAP_RS08495	COG3391	amine dehydrogenase activity
MSMAP_RS08520	COG1136	(ABC) transporter
MSMAP_RS08545	COG1122	ATPase activity
MSMAP_RS08580	COG1324	tolerance protein
MSMAP_RS08590	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAP_RS08610	COG2153	protein acetylation
MSMAP_RS08640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSMAP_RS08650	COG0588	phosphoglycerate mutase activity
MSMAP_RS08760	COG1373	ATPase (AAA superfamily
MSMAP_RS08805	COG5012	cobalamin binding
MSMAP_RS08850	COG0745	RESPONSE REGULATOR receiver
MSMAP_RS08855	COG0745	RESPONSE REGULATOR receiver
MSMAP_RS08860	COG2326	polyphosphate kinase activity
MSMAP_RS08905	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSMAP_RS08945	COG1045	serine acetyltransferase
MSMAP_RS08980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAP_RS09040	COG1295	ribonuclease BN
MSMAP_RS09070	COG0667	Aldo Keto reductase
MSMAP_RS09105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MSMAP_RS09120	COG1741	Belongs to the pirin family
MSMAP_RS09155	COG1741	Belongs to the pirin family
MSMAP_RS09170	COG1136	(ABC) transporter
MSMAP_RS09180	COG1136	(ABC) transporter
MSMAP_RS09180	COG0577	efflux transmembrane transporter activity
MSMAP_RS09185	COG3431	PFAM Phosphate-starvation-inducible E
MSMAP_RS09190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAP_RS09225	COG2205	protein histidine kinase activity
MSMAP_RS09225	COG5002	protein histidine kinase activity
MSMAP_RS09225	COG0784	Response regulator, receiver
MSMAP_RS09230	COG0784	Response regulator, receiver
MSMAP_RS09255	COG0628	permease
MSMAP_RS09260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSMAP_RS09365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSMAP_RS09380	COG0628	permease
MSMAP_RS09390	COG1846	Transcriptional regulator
MSMAP_RS09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSMAP_RS09410	COG0730	response to heat
MSMAP_RS09445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MSMAP_RS09465	COG0356	it plays a direct role in the translocation of protons across the membrane
MSMAP_RS09475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MSMAP_RS09480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MSMAP_RS09490	COG0531	amino acid
MSMAP_RS09625	COG0148	phosphopyruvate hydratase activity
MSMAP_RS09640	COG1136	(ABC) transporter
MSMAP_RS09660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MSMAP_RS09680	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSMAP_RS09685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSMAP_RS09690	COG0134	indole-3-glycerol-phosphate synthase activity
MSMAP_RS09695	COG0133	tryptophan synthase activity
MSMAP_RS09700	COG0159	tryptophan synthase activity
MSMAP_RS09705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSMAP_RS09710	COG0135	phosphoribosylanthranilate isomerase activity
MSMAP_RS09715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MSMAP_RS09720	COG0512	Glutamine amidotransferase of anthranilate synthase
MSMAP_RS09720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSMAP_RS09785	COG0367	asparagine synthase
MSMAP_RS09820	COG1741	Belongs to the pirin family
MSMAP_RS09825	COG0037	tRNA processing
MSMAP_RS09840	COG0746	molybdenum cofactor guanylyltransferase activity
MSMAP_RS09850	COG2003	Belongs to the UPF0758 family
MSMAP_RS09880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAP_RS09885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSMAP_RS09895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSMAP_RS09920	COG1254	Belongs to the acylphosphatase family
MSMAP_RS09960	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSMAP_RS09980	COG0628	permease
MSMAP_RS09995	COG2195	Cleaves the N-terminal amino acid of tripeptides
MSMAP_RS10040	COG0494	nUDIX hydrolase
MSMAP_RS10055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAP_RS10090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAP_RS10100	COG2095	MarC family integral membrane protein
MSMAP_RS10120	COG0574	Belongs to the PEP-utilizing enzyme family
MSMAP_RS10120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSMAP_RS10125	COG0590	tRNA wobble adenosine to inosine editing
MSMAP_RS10150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MSMAP_RS10165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSMAP_RS10170	COG1793	dna ligase
MSMAP_RS10175	COG0460	homoserine dehydrogenase
MSMAP_RS10270	COG0714	Associated with various cellular activities
MSMAP_RS10280	COG1136	(ABC) transporter
MSMAP_RS10295	COG1115	amino acid carrier protein
MSMAP_RS10310	COG0456	acetyltransferase
MSMAP_RS10315	COG0456	acetyltransferase
MSMAP_RS10325	COG0864	Transcriptional regulator
MSMAP_RS10330	COG1047	Peptidyl-prolyl cis-trans
MSMAP_RS10345	COG0826	peptidase U32
MSMAP_RS10350	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSMAP_RS10370	COG0436	Aminotransferase
MSMAP_RS10385	COG2414	aldehyde ferredoxin oxidoreductase
MSMAP_RS10420	COG0598	Magnesium transport protein CorA
MSMAP_RS10450	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSMAP_RS10455	COG0668	transmembrane transport
MSMAP_RS10475	COG4106	trans-aconitate 2-methyltransferase activity
MSMAP_RS10485	COG0281	malic enzyme
MSMAP_RS10500	COG2205	protein histidine kinase activity
MSMAP_RS10525	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAP_RS10530	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAP_RS10550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSMAP_RS10575	COG1704	LemA family
MSMAP_RS10585	COG1111	helicase
MSMAP_RS10585	COG1205	dead DEAH box helicase
MSMAP_RS10590	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MSMAP_RS10605	COG0732	type I restriction modification DNA specificity domain
MSMAP_RS10715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSMAP_RS10750	COG0145	ligase activity
MSMAP_RS10755	COG0145	ligase activity
MSMAP_RS10760	COG1945	arginine decarboxylase activity
MSMAP_RS10805	COG0697	spore germination
MSMAP_RS10820	COG0805	protein transport
MSMAP_RS10825	COG0805	protein transport
MSMAP_RS10830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSMAP_RS10835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSMAP_RS10860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSMAP_RS10860	COG1918	ferrous iron import across plasma membrane
MSMAP_RS10875	COG1321	iron dependent repressor
MSMAP_RS10890	COG4608	Belongs to the ABC transporter superfamily
MSMAP_RS10895	COG0444	Belongs to the ABC transporter superfamily
MSMAP_RS10900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAP_RS10905	COG0601	transmembrane transport
MSMAP_RS10955	COG1162	GTPase activity
MSMAP_RS10985	COG0753	catalase activity
MSMAP_RS11010	COG3586	endonuclease activity
MSMAP_RS11060	COG2816	NAD+ diphosphatase activity
MSMAP_RS11065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAP_RS11070	COG2890	protein-(glutamine-N5) methyltransferase activity
MSMAP_RS11075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSMAP_RS11110	COG3174	membrane
MSMAP_RS11125	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MSMAP_RS11155	COG0589	response to stress
MSMAP_RS11165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSMAP_RS11170	COG2205	protein histidine kinase activity
MSMAP_RS11175	COG0301	tRNA thio-modification
MSMAP_RS11180	COG0745	RESPONSE REGULATOR receiver
MSMAP_RS11225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MSMAP_RS11230	COG0443	Heat shock 70 kDa protein
MSMAP_RS11235	COG0484	heat shock protein binding
MSMAP_RS11245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MSMAP_RS11250	COG0569	domain protein
MSMAP_RS11280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSMAP_RS11290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSMAP_RS11310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAP_RS11315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAP_RS11320	COG0649	NAD binding
MSMAP_RS11325	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSMAP_RS11345	COG0713	ATP synthesis coupled electron transport
MSMAP_RS11355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAP_RS11360	COG1007	ATP synthesis coupled electron transport
MSMAP_RS11475	COG0105	UTP biosynthetic process
MSMAP_RS11480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSMAP_RS11495	COG0747	negative chemotaxis
MSMAP_RS11505	COG0601	transmembrane transport
MSMAP_RS11520	COG1131	(ABC) transporter
MSMAP_RS11575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MSMAP_RS11580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MSMAP_RS11590	COG0671	phosphoesterase, PA-phosphatase related
MSMAP_RS11600	COG5012	cobalamin binding
MSMAP_RS11610	COG0412	Dienelactone hydrolase
MSMAP_RS11640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MSMAP_RS11645	COG0187	DNA topoisomerase II activity
MSMAP_RS11780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSMAP_RS11785	COG4555	ABC transporter
MSMAP_RS11795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSMAP_RS11815	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAP_RS11830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAP_RS11835	COG1122	ATPase activity
MSMAP_RS11885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MSMAP_RS11920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSMAP_RS11920	COG0140	phosphoribosyl-ATP diphosphatase activity
MSMAP_RS11930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAP_RS11940	COG0436	Aminotransferase
MSMAP_RS11945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSMAP_RS11960	COG0481	GTPase activity
MSMAP_RS11980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSMAP_RS11990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSMAP_RS12070	COG1012	belongs to the aldehyde dehydrogenase family
MSMAP_RS12075	COG0028	Belongs to the TPP enzyme family
MSMAP_RS12110	COG2076	Multidrug Resistance protein
MSMAP_RS12125	COG4895	conserved protein (DUF2196)
MSMAP_RS12135	COG2217	Heavy metal translocating P-type atpase
MSMAP_RS12145	COG2608	mercury ion transmembrane transporter activity
MSMAP_RS12155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MSMAP_RS12160	COG0649	NAD binding
MSMAP_RS12170	COG3260	NADH ubiquinone oxidoreductase 20
MSMAP_RS12175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSMAP_RS12180	COG2111	Na H antiporter
MSMAP_RS12180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSMAP_RS12185	COG0309	Hydrogenase expression formation protein (HypE)
MSMAP_RS12190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSMAP_RS12195	COG0375	protein maturation
MSMAP_RS12200	COG0409	Hydrogenase expression formation protein
MSMAP_RS12205	COG0298	carbon dioxide binding
MSMAP_RS12245	COG0165	Argininosuccinate lyase
MSMAP_RS12250	COG0252	asparaginase activity
MSMAP_RS12255	COG4145	pantothenate transmembrane transporter activity
MSMAP_RS12270	COG3875	lactate racemase activity
MSMAP_RS12275	COG3875	lactate racemase activity
MSMAP_RS12285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MSMAP_RS12315	COG0587	DNA-directed DNA polymerase activity
MSMAP_RS12320	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSMAP_RS12355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MSMAP_RS12370	COG1418	mRNA catabolic process
MSMAP_RS12375	COG0402	S-adenosylhomocysteine deaminase activity
MSMAP_RS12380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSMAP_RS12415	COG0085	RNA polymerase activity
MSMAP_RS12420	COG0085	RNA polymerase activity
MSMAP_RS12425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSMAP_RS12430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSMAP_RS12450	COG0049	tRNA binding
MSMAP_RS12455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MSMAP_RS12460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSMAP_RS12465	COG0051	transcription antitermination factor activity, RNA binding
MSMAP_RS12525	COG0701	Predicted permease
MSMAP_RS12550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSMAP_RS12555	COG2226	methyltransferase
MSMAP_RS12565	COG0785	Cytochrome C biogenesis protein
MSMAP_RS12620	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAP_RS12625	COG4149	molybdate abc transporter
MSMAP_RS12630	COG3842	ATPase activity
MSMAP_RS12650	COG1473	amidohydrolase
MSMAP_RS12655	COG0456	acetyltransferase
MSMAP_RS12665	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAP_RS12670	COG0463	Glycosyl transferase, family 2
MSMAP_RS12675	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS12680	COG0463	Glycosyl transferase, family 2
MSMAP_RS12695	COG0438	transferase activity, transferring glycosyl groups
MSMAP_RS12700	COG1215	transferase activity, transferring glycosyl groups
MSMAP_RS12705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MSMAP_RS12755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSMAP_RS12755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSMAP_RS12765	COG0315	cyclic pyranopterin monophosphate synthase activity
MSMAP_RS12770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MSMAP_RS12785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSMAP_RS12790	COG1196	nuclear chromosome segregation
MSMAP_RS12795	COG0420	3'-5' exonuclease activity
MSMAP_RS12810	COG1592	Rubrerythrin
MSMAP_RS12825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSMAP_RS12830	COG1494	fructose-1,6-bisphosphatase
MSMAP_RS12835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAP_RS12835	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAP_RS12845	COG2202	Pas domain
MSMAP_RS12845	COG2205	protein histidine kinase activity
MSMAP_RS12860	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MSMAP_RS12895	COG0298	carbon dioxide binding
MSMAP_RS12900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSMAP_RS12955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSMAP_RS12960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSMAP_RS12970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MSMAP_RS12985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAP_RS12995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSMAP_RS13005	COG0563	adenylate kinase activity
MSMAP_RS13015	COG0200	Binds to the 23S rRNA
MSMAP_RS13025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSMAP_RS13045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MSMAP_RS13050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSMAP_RS13060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MSMAP_RS13070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MSMAP_RS13075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSMAP_RS13090	COG0255	Belongs to the universal ribosomal protein uL29 family
MSMAP_RS13095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSMAP_RS13105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSMAP_RS13115	COG0089	rRNA binding
MSMAP_RS13120	COG0088	Forms part of the polypeptide exit tunnel
MSMAP_RS13125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSMAP_RS13165	COG0501	Belongs to the peptidase M48B family
MSMAP_RS13180	COG0726	polysaccharide deacetylase
MSMAP_RS13210	COG2171	N-acyltransferase activity
MSMAP_RS13235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MSMAP_RS13295	COG1342	Belongs to the UPF0251 family
MSMAP_RS13330	COG0284	orotidine-5'-phosphate decarboxylase activity
MSMAP_RS13335	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSMAP_RS13340	COG1132	(ABC) transporter
MSMAP_RS13345	COG0390	transport system, permease component
MSMAP_RS13360	COG1458	PINc domain ribonuclease
MSMAP_RS13365	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSMAP_RS13370	COG0109	protoheme IX farnesyltransferase activity
MSMAP_RS13380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSMAP_RS13385	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MSMAP_RS13400	COG0157	Belongs to the NadC ModD family
MSMAP_RS13410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSMAP_RS13415	COG1120	ATPase activity
MSMAP_RS13445	COG0124	histidyl-tRNA synthetase
MSMAP_RS13450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSMAP_RS13455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSMAP_RS13470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAP_RS13475	COG0396	ATPase activity
MSMAP_RS13480	COG1372	Participates in initiation and elongation during chromosome replication
MSMAP_RS13480	COG0719	Fe-S assembly protein
MSMAP_RS13490	COG5012	cobalamin binding
MSMAP_RS13515	COG5012	cobalamin binding
MSMAP_RS13545	COG0436	Aminotransferase
MSMAP_RS13550	COG1522	sequence-specific DNA binding
MSMAP_RS13575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSMAP_RS13595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSMAP_RS13600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAP_RS13630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSMAP_RS13645	COG0316	Belongs to the HesB IscA family
MSMAP_RS13690	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAP_RS13695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MSMAP_RS13700	COG0704	Plays a role in the regulation of phosphate uptake
MSMAP_RS13705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSMAP_RS13710	COG0581	inorganic phosphate transmembrane transporter activity
MSMAP_RS13715	COG0573	inorganic phosphate transmembrane transporter activity
MSMAP_RS13720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSMAP_RS13725	COG0417	DNA replication proofreading
MSMAP_RS13765	COG1122	ATPase activity
MSMAP_RS13770	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAP_RS13840	COG0243	molybdopterin cofactor binding
MSMAP_RS13845	COG1229	Formylmethanofuran dehydrogenase subunit A
MSMAP_RS13910	COG0039	L-malate dehydrogenase activity
MSMAP_RS13925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSMAP_RS13945	COG4095	Psort location CytoplasmicMembrane, score
MSMAP_RS13950	COG0537	adenosine 5'-monophosphoramidase activity
MSMAP_RS13955	COG0425	Belongs to the sulfur carrier protein TusA family
MSMAP_RS13960	COG2210	Belongs to the sulfur carrier protein TusA family
MSMAP_RS13965	COG1104	cysteine desulfurase activity
MSMAP_RS13970	COG0822	iron-sulfur transferase activity
MSMAP_RS13990	COG0753	catalase activity
MSMAP_RS13990	COG0693	protein deglycase activity
MSMAP_RS13995	COG2226	methyltransferase
MSMAP_RS14000	COG0667	Aldo Keto reductase
MSMAP_RS14030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MSMAP_RS14040	COG0765	amino acid transport
MSMAP_RS14045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSMAP_RS14055	COG1739	Uncharacterized protein family UPF0029
MSMAP_RS14075	COG0697	spore germination
MSMAP_RS14080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAP_RS14100	COG1247	-acetyltransferase
MSMAP_RS14120	COG3339	Conserved Protein
MSMAP_RS14145	COG1201	RNA secondary structure unwinding
MSMAP_RS14150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSMAP_RS14175	COG0215	cysteine-tRNA ligase activity
MSMAP_RS14180	COG0424	maF-like protein
MSMAP_RS14195	COG1335	isochorismatase
MSMAP_RS14215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAP_RS14265	COG1793	dna ligase
MSMAP_RS14270	COG1796	DNA polymerase
MSMAP_RS14270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSMAP_RS14280	COG3119	arylsulfatase activity
MSMAP_RS14290	COG0668	transmembrane transport
MSMAP_RS14350	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAP_RS14355	COG2264	protein methyltransferase activity
MSMAP_RS14365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSMAP_RS14375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MSMAP_RS14380	COG1078	dGTPase activity
MSMAP_RS14390	COG0163	prenyltransferase activity
MSMAP_RS14450	COG2271	Major facilitator Superfamily
MSMAP_RS14465	COG0747	negative chemotaxis
MSMAP_RS14475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAP_RS14480	COG0444	Belongs to the ABC transporter superfamily
MSMAP_RS14485	COG4608	Belongs to the ABC transporter superfamily
MSMAP_RS14490	COG1144	Oxidoreductase
MSMAP_RS14515	COG2081	HI0933 family
MSMAP_RS14540	COG2181	nitrate reductase activity
MSMAP_RS14540	COG0247	lactate metabolic process
MSMAP_RS14550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAP_RS14580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MSMAP_RS14615	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSMAP_RS14615	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSMAP_RS14620	COG0439	Biotin carboxylase
MSMAP_RS14625	COG5016	pyruvate
MSMAP_RS14625	COG0511	ligase activity, forming carbon-carbon bonds
MSMAP_RS14650	COG2255	four-way junction helicase activity
MSMAP_RS14655	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MSMAP_RS14680	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MSMAP_RS14710	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAP_RS14730	COG1592	Rubrerythrin
MSMAP_RS14765	COG0459	protein refolding
MSMAP_RS14770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSMAP_RS14780	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAP_RS14910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSMAP_RS14910	COG0574	Belongs to the PEP-utilizing enzyme family
MSMAP_RS14935	COG0142	geranyltranstransferase activity
MSMAP_RS14940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSMAP_RS14945	COG1304	FMN binding
MSMAP_RS14955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MSMAP_RS14960	COG1355	regulation of microtubule-based process
MSMAP_RS14965	COG0052	Belongs to the universal ribosomal protein uS2 family
MSMAP_RS14985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSMAP_RS14990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSMAP_RS15005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MSMAP_RS15025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MSMAP_RS15035	COG0179	Fumarylacetoacetate (FAA) hydrolase
MSMAP_RS15040	COG0543	2 iron, 2 sulfur cluster binding
MSMAP_RS15045	COG0167	dihydroorotate dehydrogenase activity
MSMAP_RS15050	COG0181	hydroxymethylbilane synthase activity
MSMAP_RS15060	COG0113	porphobilinogen synthase activity
MSMAP_RS15065	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSMAP_RS15070	COG1648	precorrin-2 dehydrogenase activity
MSMAP_RS15070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSMAP_RS15075	COG1522	sequence-specific DNA binding
MSMAP_RS15085	COG0535	radical SAM domain protein
MSMAP_RS15110	COG1522	sequence-specific DNA binding
MSMAP_RS15120	COG0535	radical SAM domain protein
MSMAP_RS15195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSMAP_RS15200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSMAP_RS15205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSMAP_RS15205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSMAP_RS15225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSMAP_RS15235	COG0107	imidazoleglycerol-phosphate synthase activity
MSMAP_RS15255	COG0826	peptidase U32
MSMAP_RS15260	COG3613	nucleoside 2-deoxyribosyltransferase
MSMAP_RS15305	COG5012	cobalamin binding
MSMAP_RS15320	COG5012	cobalamin binding
MSMAP_RS15335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSMAP_RS15355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSMAP_RS15360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSMAP_RS15365	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MSMAP_RS15390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSMAP_RS15395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MSMAP_RS15430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAP_RS15455	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAP_RS15460	COG2239	Acts as a magnesium transporter
MSMAP_RS15475	COG0723	plastoquinol--plastocyanin reductase activity
MSMAP_RS15475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MSMAP_RS15485	COG1215	transferase activity, transferring glycosyl groups
MSMAP_RS15520	COG5012	cobalamin binding
MSMAP_RS15625	COG0577	efflux transmembrane transporter activity
MSMAP_RS15635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSMAP_RS15660	COG1830	Aldolase
MSMAP_RS15675	COG0523	cobalamin synthesis protein
MSMAP_RS15700	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MSMAP_RS15705	COG1691	(AIR) carboxylase
MSMAP_RS15730	COG0528	UMP kinase activity
MSMAP_RS15740	COG1136	(ABC) transporter
MSMAP_RS15740	COG0577	efflux transmembrane transporter activity
MSMAP_RS15745	COG1136	(ABC) transporter
MSMAP_RS15750	COG0456	acetyltransferase
MSMAP_RS15760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSMAP_RS15800	COG0428	transporter
MSMAP_RS15870	COG1733	regulation of RNA biosynthetic process
MSMAP_RS15895	COG2249	NAD(P)H dehydrogenase (quinone) activity
MSMAP_RS15900	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAP_RS15910	COG3842	ATPase activity
MSMAP_RS15955	COG0243	molybdopterin cofactor binding
MSMAP_RS15970	COG1229	Formylmethanofuran dehydrogenase subunit A
MSMAP_RS15985	COG3842	ATPase activity
MSMAP_RS15990	COG4662	Binding-protein-dependent transport system inner membrane component
MSMAP_RS16065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSMAP_RS16110	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSMAP_RS16130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSMAP_RS16135	COG0235	Class ii aldolase
MSMAP_RS16150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSMAP_RS16155	COG0714	Associated with various cellular activities
MSMAP_RS16160	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MSMAP_RS16170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MSMAP_RS16175	COG0372	Belongs to the citrate synthase family
MSMAP_RS16200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSMAP_RS16205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSMAP_RS16210	COG1606	tRNA processing
MSMAP_RS16215	COG1247	-acetyltransferase
MSMAP_RS16230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSMAP_RS16290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSMAP_RS16295	COG0131	Imidazoleglycerol-phosphate dehydratase
MSMAP_RS16300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSMAP_RS16305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSMAP_RS16310	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSMAP_RS16335	COG0024	Methionine aminopeptidase
MSMAP_RS16355	COG0101	tRNA pseudouridine synthase activity
MSMAP_RS16380	COG0066	3-isopropylmalate dehydratase activity
MSMAP_RS16385	COG0473	3-isopropylmalate dehydrogenase activity
MSMAP_RS16395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS16425	COG4279	zinc finger
MSMAP_RS16430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSMAP_RS16435	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSMAP_RS16455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS16460	COG0535	radical SAM domain protein
MSMAP_RS16505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAP_RS16530	COG0589	response to stress
MSMAP_RS16535	COG0589	response to stress
MSMAP_RS16545	COG0589	response to stress
MSMAP_RS16565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAP_RS16565	COG0731	radical SAM domain protein
MSMAP_RS16580	COG1342	Belongs to the UPF0251 family
MSMAP_RS16595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSMAP_RS16600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MSMAP_RS16615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSMAP_RS16625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAP_RS16630	COG5012	cobalamin binding
MSMAP_RS16645	COG0531	amino acid
MSMAP_RS16690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSMAP_RS16695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSMAP_RS16710	COG0778	Nitroreductase
MSMAP_RS16710	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MSMAP_RS16720	COG0071	Belongs to the small heat shock protein (HSP20) family
MSMAP_RS16730	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSMAP_RS16740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSMAP_RS16790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSMAP_RS16795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSMAP_RS16805	COG1183	phosphatidylcholine synthase activity
MSMAP_RS16810	COG0688	phosphatidylethanolamine metabolic process
MSMAP_RS16850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MSMAP_RS16855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSMAP_RS16860	COG1584	GPR1 FUN34 yaaH family protein
MSMAP_RS16875	COG0423	glycine-tRNA ligase activity
MSMAP_RS16880	COG0322	excinuclease ABC activity
MSMAP_RS16900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSMAP_RS16915	COG0443	Heat shock 70 kDa protein
MSMAP_RS16920	COG0459	protein refolding
MSMAP_RS16940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MSMAP_RS16945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSMAP_RS16960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSMAP_RS16970	COG1260	myo-inositol-1-phosphate synthase
MSMAP_RS16995	COG0602	queuosine metabolic process
MSMAP_RS17000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSMAP_RS17020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSMAP_RS17035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS17040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS17045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS17050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAP_RS17090	COG0018	arginyl-trna synthetase
MSMAP_RS17130	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAP_RS17135	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSMAP_RS17150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MSMAP_RS17155	COG1121	(ABC) transporter
MSMAP_RS17170	COG2610	gluconate transmembrane transporter activity
MSMAP_RS17180	COG0840	transmembrane signaling receptor activity
MSMAP_RS17185	COG0784	Response regulator, receiver
MSMAP_RS17190	COG2201	protein-glutamate methylesterase activity
MSMAP_RS17195	COG2201	protein-glutamate methylesterase activity
MSMAP_RS17200	COG0643	Histidine kinase
MSMAP_RS17200	COG2198	Histidine kinase
MSMAP_RS17205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSMAP_RS17215	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSMAP_RS17220	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSMAP_RS17240	COG0076	glutamate decarboxylase activity
MSMAP_RS17250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSMAP_RS17280	COG1216	Glycosyl transferase, family 2
MSMAP_RS17285	COG1215	transferase activity, transferring glycosyl groups
MSMAP_RS17325	COG3920	Histidine kinase
MSMAP_RS17445	COG0463	Glycosyl transferase, family 2
MSMAP_RS17480	COG1742	UPF0060 membrane protein
MSMAP_RS17535	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAP_RS17580	COG3344	reverse transcriptase
MSMAP_RS17600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MSMAP_RS17605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MSMAP_RS17610	COG1773	rubredoxin
MSMAP_RS17685	COG4251	negative regulation of phosphorylation
MSMAP_RS17725	COG2205	protein histidine kinase activity
MSMAP_RS17895	COG0589	response to stress