locus-tag	class	description
MSMAW_RS00050	COG0516	GMP reductase activity
MSMAW_RS00050	COG0517	IMP dehydrogenase activity
MSMAW_RS00055	COG0516	GMP reductase activity
MSMAW_RS00085	COG0430	RNA-3'-phosphate cyclase activity
MSMAW_RS00090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAW_RS00125	COG0456	acetyltransferase
MSMAW_RS00135	COG0277	FAD linked oxidase domain protein
MSMAW_RS00140	COG0247	lactate metabolic process
MSMAW_RS00165	COG0084	hydrolase, TatD family'
MSMAW_RS00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAW_RS00220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAW_RS00225	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSMAW_RS00230	COG2022	thiamine diphosphate biosynthetic process
MSMAW_RS00235	COG2890	protein-(glutamine-N5) methyltransferase activity
MSMAW_RS00245	COG1605	Chorismate mutase
MSMAW_RS00245	COG0287	Prephenate dehydrogenase
MSMAW_RS00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSMAW_RS00255	COG0710	3-dehydroquinate dehydratase activity
MSMAW_RS00260	COG1465	3-dehydroquinate synthase
MSMAW_RS00265	COG1830	Aldolase
MSMAW_RS00270	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAW_RS00270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAW_RS00275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSMAW_RS00325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS00360	COG1850	ribulose-bisphosphate carboxylase activity
MSMAW_RS00365	COG0009	L-threonylcarbamoyladenylate synthase
MSMAW_RS00415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSMAW_RS00420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSMAW_RS00425	COG0501	Belongs to the peptidase M48B family
MSMAW_RS00430	COG1715	Restriction endonuclease
MSMAW_RS00435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MSMAW_RS00450	COG2264	protein methyltransferase activity
MSMAW_RS00460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSMAW_RS00465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAW_RS00470	COG0154	amidase activity
MSMAW_RS00475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAW_RS00480	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSMAW_RS00495	COG1469	GTP cyclohydrolase I activity
MSMAW_RS00505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSMAW_RS00515	COG0519	Catalyzes the synthesis of GMP from XMP
MSMAW_RS00515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSMAW_RS00520	COG0514	ATP-dependent DNA helicase (RecQ)
MSMAW_RS00540	COG0540	Belongs to the ATCase OTCase family
MSMAW_RS00545	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MSMAW_RS00600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSMAW_RS00605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSMAW_RS00670	COG0463	Glycosyl transferase, family 2
MSMAW_RS00695	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS00705	COG1216	Glycosyl transferase, family 2
MSMAW_RS00720	COG2244	polysaccharide biosynthetic process
MSMAW_RS00735	COG1091	dTDP-4-dehydrorhamnose reductase activity
MSMAW_RS00750	COG0463	Glycosyl transferase, family 2
MSMAW_RS00755	COG2361	Protein of unknown function DUF86
MSMAW_RS00765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSMAW_RS00780	COG1254	Belongs to the acylphosphatase family
MSMAW_RS00815	COG0673	inositol 2-dehydrogenase activity
MSMAW_RS00865	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS00870	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS00875	COG1216	Glycosyl transferase, family 2
MSMAW_RS00885	COG1216	Glycosyl transferase, family 2
MSMAW_RS00885	COG0463	Glycosyl transferase, family 2
MSMAW_RS00890	COG0297	glycogen (starch) synthase activity
MSMAW_RS00890	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS00895	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS00910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSMAW_RS00915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSMAW_RS00920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MSMAW_RS00945	COG0463	Glycosyl transferase, family 2
MSMAW_RS00950	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS00985	COG1442	glycosyl transferase family 8
MSMAW_RS00985	COG1216	Glycosyl transferase, family 2
MSMAW_RS01020	COG1891	lyase activity
MSMAW_RS01025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSMAW_RS01035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSMAW_RS01055	COG0560	Phosphoserine phosphatase
MSMAW_RS01055	COG3830	Belongs to the UPF0237 family
MSMAW_RS01075	COG0109	protoheme IX farnesyltransferase activity
MSMAW_RS01080	COG0343	queuine tRNA-ribosyltransferase activity
MSMAW_RS01100	COG0459	protein refolding
MSMAW_RS01120	COG4251	negative regulation of phosphorylation
MSMAW_RS01125	COG4251	negative regulation of phosphorylation
MSMAW_RS01130	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAW_RS01135	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAW_RS01145	COG1372	Participates in initiation and elongation during chromosome replication
MSMAW_RS01145	COG0719	Fe-S assembly protein
MSMAW_RS01150	COG0396	ATPase activity
MSMAW_RS01175	COG0012	GTP binding
MSMAW_RS01215	COG1584	GPR1 FUN34 yaaH family protein
MSMAW_RS01225	COG5012	cobalamin binding
MSMAW_RS01235	COG0523	cobalamin synthesis protein
MSMAW_RS01250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAW_RS01255	COG0784	Response regulator, receiver
MSMAW_RS01270	COG3261	NADH dehydrogenase
MSMAW_RS01270	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MSMAW_RS01275	COG0651	ATP synthesis coupled electron transport
MSMAW_RS01290	COG0651	ATP synthesis coupled electron transport
MSMAW_RS01300	COG4152	abc transporter atp-binding protein
MSMAW_RS01350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MSMAW_RS01360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAW_RS01365	COG0303	'Molybdopterin
MSMAW_RS01390	COG0640	Transcriptional regulator
MSMAW_RS01400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAW_RS01405	COG1122	ATPase activity
MSMAW_RS01410	COG1122	ATPase activity
MSMAW_RS01415	COG1268	BioY protein
MSMAW_RS01425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSMAW_RS01435	COG1918	ferrous iron import across plasma membrane
MSMAW_RS01435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSMAW_RS01450	COG1196	nuclear chromosome segregation
MSMAW_RS01460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSMAW_RS01480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSMAW_RS01535	COG0535	radical SAM domain protein
MSMAW_RS01545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSMAW_RS01550	COG0081	regulation of translation
MSMAW_RS01555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSMAW_RS01570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSMAW_RS01585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS01600	COG0473	3-isopropylmalate dehydrogenase activity
MSMAW_RS01605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAW_RS01660	COG0489	protein tyrosine kinase activity
MSMAW_RS01665	COG1342	Belongs to the UPF0251 family
MSMAW_RS01680	COG0489	protein tyrosine kinase activity
MSMAW_RS01705	COG2048	Heterodisulfide reductase, subunit B
MSMAW_RS01735	COG0024	Methionine aminopeptidase
MSMAW_RS01885	COG0067	glutamate synthase
MSMAW_RS01905	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MSMAW_RS01930	COG0347	Belongs to the P(II) protein family
MSMAW_RS01935	COG0004	ammonium transporteR
MSMAW_RS01965	COG1136	(ABC) transporter
MSMAW_RS01975	COG0577	efflux transmembrane transporter activity
MSMAW_RS01980	COG1136	(ABC) transporter
MSMAW_RS01990	COG2205	protein histidine kinase activity
MSMAW_RS01995	COG0577	efflux transmembrane transporter activity
MSMAW_RS02010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MSMAW_RS02015	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MSMAW_RS02025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MSMAW_RS02045	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAW_RS02050	COG4962	Type ii secretion system protein e
MSMAW_RS02065	COG0456	acetyltransferase
MSMAW_RS02070	COG1509	lysine 2,3-aminomutase activity
MSMAW_RS02105	COG1476	TRANSCRIPTIONal
MSMAW_RS02120	COG0010	Belongs to the arginase family
MSMAW_RS02135	COG0494	nUDIX hydrolase
MSMAW_RS02140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSMAW_RS02140	COG5549	protein import
MSMAW_RS02180	COG1122	ATPase activity
MSMAW_RS02185	COG2217	Heavy metal translocating P-type atpase
MSMAW_RS02205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSMAW_RS02215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSMAW_RS02225	COG1584	GPR1 FUN34 yaaH family protein
MSMAW_RS02230	COG0500	methyltransferase
MSMAW_RS02250	COG0138	bifunctional purine biosynthesis protein purh
MSMAW_RS02255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAW_RS02260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAW_RS02270	COG0310	cobalt ion transport
MSMAW_RS02275	COG2226	methyltransferase
MSMAW_RS02290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAW_RS02295	COG1122	ATPase activity
MSMAW_RS02300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSMAW_RS02385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MSMAW_RS02390	COG0183	Belongs to the thiolase family
MSMAW_RS02405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSMAW_RS02405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSMAW_RS02410	COG0616	signal peptide processing
MSMAW_RS02415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSMAW_RS02465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSMAW_RS02470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS02475	COG0321	lipoyl(octanoyl) transferase activity
MSMAW_RS02475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSMAW_RS02490	COG2155	Conserved Protein
MSMAW_RS02500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSMAW_RS02540	COG0864	Transcriptional regulator
MSMAW_RS02545	COG0640	Transcriptional regulator
MSMAW_RS02550	COG1216	Glycosyl transferase, family 2
MSMAW_RS02560	COG1012	belongs to the aldehyde dehydrogenase family
MSMAW_RS02575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAW_RS02600	COG0303	'Molybdopterin
MSMAW_RS02605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSMAW_RS02610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSMAW_RS02625	COG0517	IMP dehydrogenase activity
MSMAW_RS02635	COG0402	S-adenosylhomocysteine deaminase activity
MSMAW_RS02655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSMAW_RS02660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSMAW_RS02665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MSMAW_RS02670	COG0450	alkyl hydroperoxide reductase
MSMAW_RS02685	COG1983	PspC domain protein
MSMAW_RS02690	COG0552	protein localization to endoplasmic reticulum
MSMAW_RS02735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSMAW_RS02750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS02820	COG1269	ATP hydrolysis coupled proton transport
MSMAW_RS02845	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MSMAW_RS02850	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MSMAW_RS02885	COG4572	Cation transport regulator
MSMAW_RS02960	COG2144	transferase activity, transferring acyl groups
MSMAW_RS02970	COG0535	radical SAM domain protein
MSMAW_RS02970	COG1433	Dinitrogenase iron-molybdenum cofactor
MSMAW_RS02980	COG1433	Dinitrogenase iron-molybdenum cofactor
MSMAW_RS02980	COG0535	radical SAM domain protein
MSMAW_RS02985	COG0720	synthase
MSMAW_RS02990	COG0602	queuosine metabolic process
MSMAW_RS03000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSMAW_RS03025	COG1063	alcohol dehydrogenase
MSMAW_RS03030	COG2226	methyltransferase
MSMAW_RS03035	COG0513	Belongs to the DEAD box helicase family
MSMAW_RS03060	COG0798	PFAM Bile acid sodium symporter
MSMAW_RS03090	COG1742	UPF0060 membrane protein
MSMAW_RS03100	COG0004	ammonium transporteR
MSMAW_RS03105	COG0347	Belongs to the P(II) protein family
MSMAW_RS03110	COG2226	methyltransferase
MSMAW_RS03120	COG3842	ATPase activity
MSMAW_RS03125	COG4149	molybdate abc transporter
MSMAW_RS03130	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAW_RS03155	COG0347	Belongs to the P(II) protein family
MSMAW_RS03165	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSMAW_RS03170	COG0644	oxidoreductase
MSMAW_RS03225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSMAW_RS03230	COG0442	prolyl-tRNA aminoacylation
MSMAW_RS03260	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSMAW_RS03265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSMAW_RS03285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSMAW_RS03290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSMAW_RS03295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSMAW_RS03390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSMAW_RS03405	COG1363	Peptidase, m42
MSMAW_RS03415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAW_RS03420	COG0028	Belongs to the TPP enzyme family
MSMAW_RS03425	COG0440	acetolactate synthase activity
MSMAW_RS03430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSMAW_RS03435	COG0778	Nitroreductase
MSMAW_RS03440	COG0864	Transcriptional regulator
MSMAW_RS03455	COG0493	'glutamate synthase
MSMAW_RS03465	COG0640	Transcriptional regulator
MSMAW_RS03470	COG2226	methyltransferase
MSMAW_RS03485	COG1215	transferase activity, transferring glycosyl groups
MSMAW_RS03510	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS03530	COG0066	3-isopropylmalate dehydratase activity
MSMAW_RS03545	COG0473	3-isopropylmalate dehydrogenase activity
MSMAW_RS03560	COG3527	Alpha-acetolactate decarboxylase
MSMAW_RS03565	COG0426	domain, Protein
MSMAW_RS03585	COG0431	NADPH-dependent FMN reductase
MSMAW_RS03595	COG2033	superoxide reductase activity
MSMAW_RS03625	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSMAW_RS03650	COG1331	Highly conserved protein containing a thioredoxin domain
MSMAW_RS03710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSMAW_RS03730	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAW_RS03740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSMAW_RS03745	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAW_RS03770	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSMAW_RS03785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSMAW_RS03790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSMAW_RS03820	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAW_RS03850	COG0371	Dehydrogenase
MSMAW_RS03865	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS03900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAW_RS03935	COG1203	CRISPR-associated helicase, Cas3
MSMAW_RS03940	COG1518	maintenance of DNA repeat elements
MSMAW_RS03945	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MSMAW_RS03990	COG0557	exoribonuclease II activity
MSMAW_RS04030	COG0662	Cupin 2, conserved barrel domain protein
MSMAW_RS04075	COG0531	amino acid
MSMAW_RS04120	COG4191	Histidine kinase
MSMAW_RS04140	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSMAW_RS04160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSMAW_RS04180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAW_RS04215	COG0038	chloride channel
MSMAW_RS04220	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAW_RS04225	COG0280	phosphate acetyltransferase
MSMAW_RS04230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSMAW_RS04235	COG1042	CoA-binding domain protein
MSMAW_RS04235	COG0045	succinate-CoA ligase (ADP-forming) activity
MSMAW_RS04235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAW_RS04270	COG1573	uracil-dna glycosylase
MSMAW_RS04275	COG0126	phosphoglycerate kinase activity
MSMAW_RS04280	COG2078	PFAM AMMECR1 domain protein
MSMAW_RS04285	COG0071	Belongs to the small heat shock protein (HSP20) family
MSMAW_RS04295	COG0456	acetyltransferase
MSMAW_RS04300	COG3613	nucleoside 2-deoxyribosyltransferase
MSMAW_RS04310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSMAW_RS04315	COG0517	IMP dehydrogenase activity
MSMAW_RS04320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSMAW_RS04390	COG0310	cobalt ion transport
MSMAW_RS04395	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSMAW_RS04405	COG1122	ATPase activity
MSMAW_RS04425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSMAW_RS04435	COG0561	phosphatase activity
MSMAW_RS04470	COG0384	phenazine biosynthesis protein PhzF
MSMAW_RS04475	COG2226	methyltransferase
MSMAW_RS04495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS04515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSMAW_RS04520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSMAW_RS04525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSMAW_RS04530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSMAW_RS04550	COG3118	belongs to the thioredoxin family
MSMAW_RS04575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAW_RS04580	COG0732	type I restriction modification DNA specificity domain
MSMAW_RS04585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAW_RS04600	COG1121	(ABC) transporter
MSMAW_RS04605	COG4581	dead DEAH box helicase
MSMAW_RS04610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MSMAW_RS04630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSMAW_RS04630	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAW_RS04635	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSMAW_RS04815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAW_RS04850	COG5658	integral membrane protein
MSMAW_RS04865	COG1047	Peptidyl-prolyl cis-trans
MSMAW_RS04905	COG0714	Associated with various cellular activities
MSMAW_RS04915	COG1605	Chorismate mutase
MSMAW_RS04915	COG0077	Prephenate dehydratase
MSMAW_RS04955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAW_RS04960	COG1733	regulation of RNA biosynthetic process
MSMAW_RS04965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAW_RS04975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSMAW_RS04975	COG1042	CoA-binding domain protein
MSMAW_RS04975	COG0045	succinate-CoA ligase (ADP-forming) activity
MSMAW_RS04980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MSMAW_RS05005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAW_RS05025	COG1846	Transcriptional regulator
MSMAW_RS05035	COG0534	Mate efflux family protein
MSMAW_RS05050	COG0432	Pfam Uncharacterised protein family UPF0047
MSMAW_RS05055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSMAW_RS05065	COG0351	phosphomethylpyrimidine kinase
MSMAW_RS05065	COG0352	thiamine-phosphate diphosphorylase activity
MSMAW_RS05070	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MSMAW_RS05090	COG0840	transmembrane signaling receptor activity
MSMAW_RS05090	COG3290	protein histidine kinase activity
MSMAW_RS05095	COG0835	chemotaxis
MSMAW_RS05105	COG2201	protein-glutamate methylesterase activity
MSMAW_RS05110	COG2201	protein-glutamate methylesterase activity
MSMAW_RS05115	COG0643	Histidine kinase
MSMAW_RS05115	COG2198	Histidine kinase
MSMAW_RS05115	COG0643	Histidine kinase
MSMAW_RS05115	COG2198	Histidine kinase
MSMAW_RS05120	COG1776	CheC inhibitor of MCP methylation
MSMAW_RS05125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSMAW_RS05215	COG0535	radical SAM domain protein
MSMAW_RS05230	COG1234	tRNA 3'-trailer cleavage
MSMAW_RS05240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS05255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSMAW_RS05260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSMAW_RS05265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSMAW_RS05270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAW_RS05280	COG0517	IMP dehydrogenase activity
MSMAW_RS05280	COG1125	glycine betaine transport
MSMAW_RS05290	COG1174	glycine betaine transport
MSMAW_RS05340	COG1945	arginine decarboxylase activity
MSMAW_RS05350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSMAW_RS05355	COG0495	leucyl-tRNA aminoacylation
MSMAW_RS05360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MSMAW_RS05380	COG1401	restriction endodeoxyribonuclease activity
MSMAW_RS05440	COG0653	protein targeting
MSMAW_RS05445	COG0426	domain, Protein
MSMAW_RS05455	COG0129	dihydroxy-acid dehydratase activity
MSMAW_RS05465	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSMAW_RS05575	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAW_RS05580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSMAW_RS05585	COG0617	tRNA 3'-terminal CCA addition
MSMAW_RS05585	COG0517	IMP dehydrogenase activity
MSMAW_RS05585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MSMAW_RS05590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MSMAW_RS05600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSMAW_RS05605	COG0436	Aminotransferase
MSMAW_RS05615	COG0516	GMP reductase activity
MSMAW_RS05615	COG0517	IMP dehydrogenase activity
MSMAW_RS05640	COG0668	transmembrane transport
MSMAW_RS05655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSMAW_RS05705	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MSMAW_RS05820	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAW_RS05840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAW_RS05860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAW_RS05870	COG2361	Protein of unknown function DUF86
MSMAW_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
MSMAW_RS05905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSMAW_RS05910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSMAW_RS05940	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MSMAW_RS05955	COG5012	cobalamin binding
MSMAW_RS06000	COG0784	Response regulator, receiver
MSMAW_RS06000	COG4191	Histidine kinase
MSMAW_RS06015	COG3920	Histidine kinase
MSMAW_RS06030	COG5310	Homospermidine synthase
MSMAW_RS06050	COG3189	MarR family transcriptional regulator
MSMAW_RS06070	COG1151	hydroxylamine reductase activity
MSMAW_RS06130	COG0210	DNA helicase
MSMAW_RS06140	COG1401	restriction endodeoxyribonuclease activity
MSMAW_RS06170	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAW_RS06220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSMAW_RS06225	COG0151	Belongs to the GarS family
MSMAW_RS06235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSMAW_RS06250	COG1138	Cytochrome C-type biogenesis protein
MSMAW_RS06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSMAW_RS06345	COG0470	DNA polymerase III
MSMAW_RS06345	COG1067	ATP-dependent peptidase activity
MSMAW_RS06350	COG0312	modulator of DNA gyrase
MSMAW_RS06355	COG0312	modulator of DNA gyrase
MSMAW_RS06360	COG0589	response to stress
MSMAW_RS06375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAW_RS06395	COG0504	CTP synthase activity
MSMAW_RS06420	COG0534	Mate efflux family protein
MSMAW_RS06425	COG0585	pseudouridine synthase activity
MSMAW_RS06450	COG0822	iron-sulfur transferase activity
MSMAW_RS06465	COG1346	cytolysis
MSMAW_RS06525	COG1492	cobalamin metabolic process
MSMAW_RS06535	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSMAW_RS06575	COG3830	Belongs to the UPF0237 family
MSMAW_RS06580	COG2848	UPF0210 protein
MSMAW_RS06595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MSMAW_RS06600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSMAW_RS06615	COG0017	Asparaginyl-tRNA synthetase
MSMAW_RS06620	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSMAW_RS06625	COG0459	protein refolding
MSMAW_RS06635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSMAW_RS06700	COG1233	COG1233 Phytoene dehydrogenase and related
MSMAW_RS06710	COG0589	response to stress
MSMAW_RS06720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSMAW_RS06730	COG1012	belongs to the aldehyde dehydrogenase family
MSMAW_RS06735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MSMAW_RS06775	COG4175	Glycine betaine
MSMAW_RS06775	COG0517	IMP dehydrogenase activity
MSMAW_RS06785	COG0505	Belongs to the CarA family
MSMAW_RS06790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSMAW_RS06795	COG0137	argininosuccinate synthase activity
MSMAW_RS06875	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAW_RS06905	COG2226	methyltransferase
MSMAW_RS06925	COG2226	methyltransferase
MSMAW_RS06930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSMAW_RS06970	COG0444	Belongs to the ABC transporter superfamily
MSMAW_RS06975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAW_RS06980	COG0601	transmembrane transport
MSMAW_RS07000	COG3344	reverse transcriptase
MSMAW_RS07060	COG0653	protein targeting
MSMAW_RS07140	COG5012	cobalamin binding
MSMAW_RS07155	COG0562	UDP-galactopyranose mutase
MSMAW_RS07170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAW_RS07180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAW_RS07190	COG1301	dicarboxylic acid transport
MSMAW_RS07200	COG4608	Belongs to the ABC transporter superfamily
MSMAW_RS07205	COG0747	negative chemotaxis
MSMAW_RS07215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAW_RS07300	COG1061	Type III restriction enzyme res subunit
MSMAW_RS07305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSMAW_RS07360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MSMAW_RS07365	COG0322	excinuclease ABC activity
MSMAW_RS07370	COG0556	nucleotide-excision repair
MSMAW_RS07375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSMAW_RS07395	COG1408	metallophosphoesterase
MSMAW_RS07425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSMAW_RS07430	COG1836	PFAM Integral membrane protein DUF92
MSMAW_RS07445	COG1253	flavin adenine dinucleotide binding
MSMAW_RS07460	COG2814	Major facilitator Superfamily
MSMAW_RS07500	COG2221	Nitrite and sulphite reductase 4Fe-4S
MSMAW_RS07510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MSMAW_RS07515	COG0668	transmembrane transport
MSMAW_RS07525	COG1511	domain protein
MSMAW_RS07525	COG3264	Mechanosensitive ion channel
MSMAW_RS07595	COG0352	thiamine-phosphate diphosphorylase activity
MSMAW_RS07600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MSMAW_RS07620	COG0306	phosphate transporter
MSMAW_RS07630	COG0300	oxidoreductase activity
MSMAW_RS07700	COG1151	hydroxylamine reductase activity
MSMAW_RS07710	COG0826	peptidase U32
MSMAW_RS07715	COG0784	Response regulator, receiver
MSMAW_RS07720	COG2205	protein histidine kinase activity
MSMAW_RS07720	COG2202	Pas domain
MSMAW_RS07725	COG0534	Mate efflux family protein
MSMAW_RS07735	COG0392	lysyltransferase activity
MSMAW_RS07735	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MSMAW_RS07740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAW_RS07745	COG0697	spore germination
MSMAW_RS07750	COG1073	alpha beta
MSMAW_RS07770	COG1846	Transcriptional regulator
MSMAW_RS07775	COG0534	Mate efflux family protein
MSMAW_RS07800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSMAW_RS07810	COG0426	domain, Protein
MSMAW_RS07815	COG0531	amino acid
MSMAW_RS07835	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAW_RS07835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSMAW_RS07845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MSMAW_RS07855	COG3291	Pkd domain containing protein
MSMAW_RS07865	COG3063	Type IV pilus biogenesis stability protein PilW
MSMAW_RS07970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS07985	COG0708	Exodeoxyribonuclease III
MSMAW_RS07990	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAW_RS08025	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAW_RS08055	COG1131	(ABC) transporter
MSMAW_RS08060	COG0501	Belongs to the peptidase M48B family
MSMAW_RS08090	COG0671	phosphoesterase, PA-phosphatase related
MSMAW_RS08125	COG2814	Major facilitator Superfamily
MSMAW_RS08135	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAW_RS08140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSMAW_RS08175	COG3485	protocatechuate 3,4-dioxygenase
MSMAW_RS08185	COG0058	SHG alpha-glucan phosphorylase activity
MSMAW_RS08200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSMAW_RS08225	COG2205	protein histidine kinase activity
MSMAW_RS08235	COG2205	protein histidine kinase activity
MSMAW_RS08250	COG0577	efflux transmembrane transporter activity
MSMAW_RS08250	COG1136	(ABC) transporter
MSMAW_RS08260	COG1136	(ABC) transporter
MSMAW_RS08305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSMAW_RS08305	COG4451	ribulose bisphosphate carboxylase, small
MSMAW_RS08320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MSMAW_RS08330	COG0693	protein deglycase activity
MSMAW_RS08370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSMAW_RS08380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSMAW_RS08410	COG0477	Major facilitator Superfamily
MSMAW_RS08415	COG2326	polyphosphate kinase activity
MSMAW_RS08430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MSMAW_RS08455	COG0658	competence protein
MSMAW_RS08455	COG2333	competence protein COMEC
MSMAW_RS08475	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS08490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MSMAW_RS08495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAW_RS08560	COG3391	amine dehydrogenase activity
MSMAW_RS08595	COG1136	(ABC) transporter
MSMAW_RS08620	COG1122	ATPase activity
MSMAW_RS08635	COG0577	efflux transmembrane transporter activity
MSMAW_RS08635	COG1136	(ABC) transporter
MSMAW_RS08655	COG1324	tolerance protein
MSMAW_RS08665	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSMAW_RS08685	COG2153	protein acetylation
MSMAW_RS08715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSMAW_RS08750	COG0588	phosphoglycerate mutase activity
MSMAW_RS08860	COG1373	ATPase (AAA superfamily
MSMAW_RS08900	COG3920	Histidine kinase
MSMAW_RS08920	COG5012	cobalamin binding
MSMAW_RS08955	COG3920	Histidine kinase
MSMAW_RS08960	COG0745	RESPONSE REGULATOR receiver
MSMAW_RS08965	COG0745	RESPONSE REGULATOR receiver
MSMAW_RS09025	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSMAW_RS09065	COG1045	serine acetyltransferase
MSMAW_RS09100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAW_RS09160	COG1295	ribonuclease BN
MSMAW_RS09195	COG0667	Aldo Keto reductase
MSMAW_RS09235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MSMAW_RS09260	COG1741	Belongs to the pirin family
MSMAW_RS09295	COG1741	Belongs to the pirin family
MSMAW_RS09310	COG1136	(ABC) transporter
MSMAW_RS09320	COG0577	efflux transmembrane transporter activity
MSMAW_RS09320	COG1136	(ABC) transporter
MSMAW_RS09325	COG3431	PFAM Phosphate-starvation-inducible E
MSMAW_RS09330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSMAW_RS09340	COG2205	protein histidine kinase activity
MSMAW_RS09340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSMAW_RS09365	COG2205	protein histidine kinase activity
MSMAW_RS09365	COG0784	Response regulator, receiver
MSMAW_RS09365	COG5002	protein histidine kinase activity
MSMAW_RS09370	COG0784	Response regulator, receiver
MSMAW_RS09390	COG0628	permease
MSMAW_RS09395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSMAW_RS09495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSMAW_RS09510	COG0628	permease
MSMAW_RS09520	COG1846	Transcriptional regulator
MSMAW_RS09535	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSMAW_RS09540	COG0730	response to heat
MSMAW_RS09590	COG0028	Belongs to the TPP enzyme family
MSMAW_RS09625	COG0148	phosphopyruvate hydratase activity
MSMAW_RS09640	COG1136	(ABC) transporter
MSMAW_RS09665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MSMAW_RS09685	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSMAW_RS09690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSMAW_RS09695	COG0134	indole-3-glycerol-phosphate synthase activity
MSMAW_RS09700	COG0133	tryptophan synthase activity
MSMAW_RS09705	COG0159	tryptophan synthase activity
MSMAW_RS09710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSMAW_RS09715	COG0135	phosphoribosylanthranilate isomerase activity
MSMAW_RS09720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MSMAW_RS09725	COG0512	Glutamine amidotransferase of anthranilate synthase
MSMAW_RS09725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSMAW_RS09805	COG0367	asparagine synthase
MSMAW_RS09845	COG1741	Belongs to the pirin family
MSMAW_RS09865	COG0746	molybdenum cofactor guanylyltransferase activity
MSMAW_RS09875	COG2003	Belongs to the UPF0758 family
MSMAW_RS09905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSMAW_RS09910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSMAW_RS09920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSMAW_RS09945	COG1254	Belongs to the acylphosphatase family
MSMAW_RS09980	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSMAW_RS10120	COG0628	permease
MSMAW_RS10135	COG2195	Cleaves the N-terminal amino acid of tripeptides
MSMAW_RS10140	COG3920	Histidine kinase
MSMAW_RS10185	COG2095	MarC family integral membrane protein
MSMAW_RS10225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSMAW_RS10225	COG0574	Belongs to the PEP-utilizing enzyme family
MSMAW_RS10230	COG0590	tRNA wobble adenosine to inosine editing
MSMAW_RS10250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MSMAW_RS10265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSMAW_RS10270	COG1793	dna ligase
MSMAW_RS10275	COG0460	homoserine dehydrogenase
MSMAW_RS10320	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAW_RS10325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAW_RS10335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MSMAW_RS10435	COG0714	Associated with various cellular activities
MSMAW_RS10445	COG1136	(ABC) transporter
MSMAW_RS10460	COG1115	amino acid carrier protein
MSMAW_RS10475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSMAW_RS10480	COG0402	S-adenosylhomocysteine deaminase activity
MSMAW_RS10485	COG1418	mRNA catabolic process
MSMAW_RS10505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MSMAW_RS10525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSMAW_RS10530	COG0587	DNA-directed DNA polymerase activity
MSMAW_RS10555	COG0052	Belongs to the universal ribosomal protein uS2 family
MSMAW_RS10560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MSMAW_RS10570	COG3875	lactate racemase activity
MSMAW_RS10575	COG3875	lactate racemase activity
MSMAW_RS10580	COG4145	pantothenate transmembrane transporter activity
MSMAW_RS10585	COG0252	asparaginase activity
MSMAW_RS10590	COG0165	Argininosuccinate lyase
MSMAW_RS10630	COG0298	carbon dioxide binding
MSMAW_RS10635	COG0409	Hydrogenase expression formation protein
MSMAW_RS10640	COG0375	protein maturation
MSMAW_RS10645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSMAW_RS10650	COG0309	Hydrogenase expression formation protein (HypE)
MSMAW_RS10655	COG2111	Na H antiporter
MSMAW_RS10655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSMAW_RS10660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSMAW_RS10665	COG3260	NADH ubiquinone oxidoreductase 20
MSMAW_RS10675	COG0649	NAD binding
MSMAW_RS10680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MSMAW_RS10690	COG2608	mercury ion transmembrane transporter activity
MSMAW_RS10700	COG2217	Heavy metal translocating P-type atpase
MSMAW_RS10710	COG4895	conserved protein (DUF2196)
MSMAW_RS10725	COG2076	Multidrug Resistance protein
MSMAW_RS10760	COG0028	Belongs to the TPP enzyme family
MSMAW_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
MSMAW_RS10800	COG0546	phosphoglycolate phosphatase activity
MSMAW_RS10820	COG0492	ferredoxin-NADP+ reductase activity
MSMAW_RS10850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSMAW_RS10860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSMAW_RS10880	COG0481	GTPase activity
MSMAW_RS10895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSMAW_RS10900	COG0436	Aminotransferase
MSMAW_RS10910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAW_RS10920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSMAW_RS10920	COG0140	phosphoribosyl-ATP diphosphatase activity
MSMAW_RS10955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MSMAW_RS11010	COG1122	ATPase activity
MSMAW_RS11015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAW_RS11030	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAW_RS11050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSMAW_RS11060	COG4555	ABC transporter
MSMAW_RS11065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSMAW_RS11180	COG0187	DNA topoisomerase II activity
MSMAW_RS11185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MSMAW_RS11230	COG0412	Dienelactone hydrolase
MSMAW_RS11240	COG5012	cobalamin binding
MSMAW_RS11250	COG0671	phosphoesterase, PA-phosphatase related
MSMAW_RS11260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MSMAW_RS11265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MSMAW_RS11455	COG1131	(ABC) transporter
MSMAW_RS11470	COG0601	transmembrane transport
MSMAW_RS11480	COG0747	negative chemotaxis
MSMAW_RS11495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSMAW_RS11500	COG0105	UTP biosynthetic process
MSMAW_RS11590	COG1007	ATP synthesis coupled electron transport
MSMAW_RS11595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAW_RS11605	COG0713	ATP synthesis coupled electron transport
MSMAW_RS11625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSMAW_RS11630	COG0649	NAD binding
MSMAW_RS11635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAW_RS11640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSMAW_RS11665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSMAW_RS11675	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSMAW_RS11705	COG0569	domain protein
MSMAW_RS11710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MSMAW_RS11720	COG0484	heat shock protein binding
MSMAW_RS11725	COG0443	Heat shock 70 kDa protein
MSMAW_RS11730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MSMAW_RS11780	COG0745	RESPONSE REGULATOR receiver
MSMAW_RS11785	COG0301	tRNA thio-modification
MSMAW_RS11790	COG2205	protein histidine kinase activity
MSMAW_RS11795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSMAW_RS11805	COG0589	response to stress
MSMAW_RS11835	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MSMAW_RS11850	COG3174	membrane
MSMAW_RS11885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSMAW_RS11890	COG2890	protein-(glutamine-N5) methyltransferase activity
MSMAW_RS11895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAW_RS11900	COG2816	NAD+ diphosphatase activity
MSMAW_RS11990	COG0753	catalase activity
MSMAW_RS12010	COG1162	GTPase activity
MSMAW_RS12050	COG0601	transmembrane transport
MSMAW_RS12055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAW_RS12060	COG0444	Belongs to the ABC transporter superfamily
MSMAW_RS12065	COG4608	Belongs to the ABC transporter superfamily
MSMAW_RS12075	COG1321	iron dependent repressor
MSMAW_RS12090	COG1918	ferrous iron import across plasma membrane
MSMAW_RS12090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSMAW_RS12125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSMAW_RS12130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSMAW_RS12135	COG0805	protein transport
MSMAW_RS12140	COG0805	protein transport
MSMAW_RS12155	COG0697	spore germination
MSMAW_RS12180	COG1945	arginine decarboxylase activity
MSMAW_RS12185	COG0145	ligase activity
MSMAW_RS12285	COG2361	Protein of unknown function DUF86
MSMAW_RS12305	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MSMAW_RS12310	COG1111	helicase
MSMAW_RS12310	COG1205	dead DEAH box helicase
MSMAW_RS12320	COG1704	LemA family
MSMAW_RS12345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSMAW_RS12365	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAW_RS12370	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAW_RS12395	COG2205	protein histidine kinase activity
MSMAW_RS12420	COG0281	malic enzyme
MSMAW_RS12430	COG4106	trans-aconitate 2-methyltransferase activity
MSMAW_RS12450	COG0668	transmembrane transport
MSMAW_RS12455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSMAW_RS12465	COG0598	Magnesium transport protein CorA
MSMAW_RS12495	COG2414	aldehyde ferredoxin oxidoreductase
MSMAW_RS12500	COG3920	Histidine kinase
MSMAW_RS12515	COG0436	Aminotransferase
MSMAW_RS12535	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSMAW_RS12540	COG0826	peptidase U32
MSMAW_RS12650	COG1047	Peptidyl-prolyl cis-trans
MSMAW_RS12655	COG0864	Transcriptional regulator
MSMAW_RS12665	COG0456	acetyltransferase
MSMAW_RS12670	COG0456	acetyltransferase
MSMAW_RS12725	COG0085	RNA polymerase activity
MSMAW_RS12730	COG0085	RNA polymerase activity
MSMAW_RS12735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSMAW_RS12740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSMAW_RS12760	COG0049	tRNA binding
MSMAW_RS12765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MSMAW_RS12770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSMAW_RS12775	COG0051	transcription antitermination factor activity, RNA binding
MSMAW_RS12835	COG0701	Predicted permease
MSMAW_RS12860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSMAW_RS12865	COG2226	methyltransferase
MSMAW_RS12875	COG0785	Cytochrome C biogenesis protein
MSMAW_RS12910	COG1473	amidohydrolase
MSMAW_RS12915	COG0456	acetyltransferase
MSMAW_RS12935	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSMAW_RS12945	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS12950	COG0463	Glycosyl transferase, family 2
MSMAW_RS12965	COG0438	transferase activity, transferring glycosyl groups
MSMAW_RS12970	COG1215	transferase activity, transferring glycosyl groups
MSMAW_RS12975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MSMAW_RS13015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSMAW_RS13015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSMAW_RS13025	COG0315	cyclic pyranopterin monophosphate synthase activity
MSMAW_RS13030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MSMAW_RS13035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSMAW_RS13050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAW_RS13065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSMAW_RS13070	COG1196	nuclear chromosome segregation
MSMAW_RS13075	COG0420	3'-5' exonuclease activity
MSMAW_RS13090	COG1592	Rubrerythrin
MSMAW_RS13115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSMAW_RS13120	COG1494	fructose-1,6-bisphosphatase
MSMAW_RS13145	COG2205	protein histidine kinase activity
MSMAW_RS13145	COG2202	Pas domain
MSMAW_RS13160	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MSMAW_RS13210	COG0298	carbon dioxide binding
MSMAW_RS13215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSMAW_RS13270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSMAW_RS13275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSMAW_RS13285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MSMAW_RS13300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAW_RS13310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSMAW_RS13320	COG0563	adenylate kinase activity
MSMAW_RS13330	COG0200	Binds to the 23S rRNA
MSMAW_RS13340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSMAW_RS13360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MSMAW_RS13365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSMAW_RS13375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MSMAW_RS13385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MSMAW_RS13390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSMAW_RS13405	COG0255	Belongs to the universal ribosomal protein uL29 family
MSMAW_RS13410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSMAW_RS13420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSMAW_RS13430	COG0089	rRNA binding
MSMAW_RS13435	COG0088	Forms part of the polypeptide exit tunnel
MSMAW_RS13440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSMAW_RS13475	COG1215	transferase activity, transferring glycosyl groups
MSMAW_RS13510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSMAW_RS13515	COG1086	Polysaccharide biosynthesis protein
MSMAW_RS13570	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAW_RS13575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSMAW_RS13585	COG0318	PFAM AMP-dependent synthetase and ligase
MSMAW_RS13620	COG1342	Belongs to the UPF0251 family
MSMAW_RS13655	COG0284	orotidine-5'-phosphate decarboxylase activity
MSMAW_RS13660	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSMAW_RS13665	COG1132	(ABC) transporter
MSMAW_RS13670	COG0390	transport system, permease component
MSMAW_RS13685	COG1458	PINc domain ribonuclease
MSMAW_RS13690	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSMAW_RS13695	COG0109	protoheme IX farnesyltransferase activity
MSMAW_RS13705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSMAW_RS13710	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MSMAW_RS13720	COG0157	Belongs to the NadC ModD family
MSMAW_RS13730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSMAW_RS13735	COG1120	ATPase activity
MSMAW_RS13765	COG0124	histidyl-tRNA synthetase
MSMAW_RS13770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSMAW_RS13775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSMAW_RS13790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSMAW_RS13795	COG0396	ATPase activity
MSMAW_RS13800	COG0719	Fe-S assembly protein
MSMAW_RS13800	COG1372	Participates in initiation and elongation during chromosome replication
MSMAW_RS13810	COG5012	cobalamin binding
MSMAW_RS13835	COG5012	cobalamin binding
MSMAW_RS13880	COG0436	Aminotransferase
MSMAW_RS13885	COG1522	sequence-specific DNA binding
MSMAW_RS13910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSMAW_RS13930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSMAW_RS13935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSMAW_RS13980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSMAW_RS13995	COG0316	Belongs to the HesB IscA family
MSMAW_RS14030	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAW_RS14035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MSMAW_RS14040	COG0704	Plays a role in the regulation of phosphate uptake
MSMAW_RS14045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSMAW_RS14050	COG0581	inorganic phosphate transmembrane transporter activity
MSMAW_RS14055	COG0573	inorganic phosphate transmembrane transporter activity
MSMAW_RS14060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSMAW_RS14065	COG0417	DNA replication proofreading
MSMAW_RS14105	COG1122	ATPase activity
MSMAW_RS14110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSMAW_RS14180	COG0243	molybdopterin cofactor binding
MSMAW_RS14185	COG1229	Formylmethanofuran dehydrogenase subunit A
MSMAW_RS14250	COG0039	L-malate dehydrogenase activity
MSMAW_RS14265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSMAW_RS14290	COG0537	adenosine 5'-monophosphoramidase activity
MSMAW_RS14295	COG0425	Belongs to the sulfur carrier protein TusA family
MSMAW_RS14300	COG2210	Belongs to the sulfur carrier protein TusA family
MSMAW_RS14305	COG1104	cysteine desulfurase activity
MSMAW_RS14310	COG0822	iron-sulfur transferase activity
MSMAW_RS14325	COG0753	catalase activity
MSMAW_RS14325	COG0693	protein deglycase activity
MSMAW_RS14330	COG2226	methyltransferase
MSMAW_RS14335	COG0667	Aldo Keto reductase
MSMAW_RS14365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MSMAW_RS14375	COG0765	amino acid transport
MSMAW_RS14380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSMAW_RS14390	COG1739	Uncharacterized protein family UPF0029
MSMAW_RS14415	COG0697	spore germination
MSMAW_RS14420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAW_RS14440	COG1247	-acetyltransferase
MSMAW_RS14460	COG3339	Conserved Protein
MSMAW_RS14470	COG1201	RNA secondary structure unwinding
MSMAW_RS14475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSMAW_RS14500	COG0215	cysteine-tRNA ligase activity
MSMAW_RS14505	COG0424	maF-like protein
MSMAW_RS14520	COG1335	isochorismatase
MSMAW_RS14535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSMAW_RS14585	COG1793	dna ligase
MSMAW_RS14590	COG1796	DNA polymerase
MSMAW_RS14590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSMAW_RS14595	COG0641	radical SAM
MSMAW_RS14600	COG3119	arylsulfatase activity
MSMAW_RS14635	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAW_RS14640	COG2264	protein methyltransferase activity
MSMAW_RS14650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSMAW_RS14660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MSMAW_RS14665	COG1078	dGTPase activity
MSMAW_RS14675	COG0163	prenyltransferase activity
MSMAW_RS14725	COG2271	Major facilitator Superfamily
MSMAW_RS14740	COG0747	negative chemotaxis
MSMAW_RS14750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSMAW_RS14755	COG0444	Belongs to the ABC transporter superfamily
MSMAW_RS14760	COG4608	Belongs to the ABC transporter superfamily
MSMAW_RS14765	COG1144	Oxidoreductase
MSMAW_RS14790	COG2081	HI0933 family
MSMAW_RS14815	COG0247	lactate metabolic process
MSMAW_RS14815	COG2181	nitrate reductase activity
MSMAW_RS14825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSMAW_RS14845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MSMAW_RS14880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSMAW_RS14880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSMAW_RS14885	COG0439	Biotin carboxylase
MSMAW_RS14890	COG5016	pyruvate
MSMAW_RS14890	COG0511	ligase activity, forming carbon-carbon bonds
MSMAW_RS14915	COG2255	four-way junction helicase activity
MSMAW_RS14920	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MSMAW_RS14950	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MSMAW_RS14980	COG1185	polyribonucleotide nucleotidyltransferase activity
MSMAW_RS15000	COG1592	Rubrerythrin
MSMAW_RS15035	COG0459	protein refolding
MSMAW_RS15040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSMAW_RS15050	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSMAW_RS15135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS15160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSMAW_RS15160	COG0574	Belongs to the PEP-utilizing enzyme family
MSMAW_RS15180	COG0142	geranyltranstransferase activity
MSMAW_RS15185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSMAW_RS15190	COG1304	FMN binding
MSMAW_RS15200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MSMAW_RS15205	COG1355	regulation of microtubule-based process
MSMAW_RS15210	COG0052	Belongs to the universal ribosomal protein uS2 family
MSMAW_RS15230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSMAW_RS15235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSMAW_RS15250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MSMAW_RS15270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MSMAW_RS15280	COG0179	Fumarylacetoacetate (FAA) hydrolase
MSMAW_RS15285	COG0543	2 iron, 2 sulfur cluster binding
MSMAW_RS15290	COG0167	dihydroorotate dehydrogenase activity
MSMAW_RS15295	COG0181	hydroxymethylbilane synthase activity
MSMAW_RS15305	COG0113	porphobilinogen synthase activity
MSMAW_RS15310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSMAW_RS15315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSMAW_RS15315	COG1648	precorrin-2 dehydrogenase activity
MSMAW_RS15320	COG1522	sequence-specific DNA binding
MSMAW_RS15330	COG0535	radical SAM domain protein
MSMAW_RS15410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSMAW_RS15415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSMAW_RS15420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSMAW_RS15420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSMAW_RS15440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSMAW_RS15450	COG0107	imidazoleglycerol-phosphate synthase activity
MSMAW_RS15470	COG0826	peptidase U32
MSMAW_RS15475	COG3613	nucleoside 2-deoxyribosyltransferase
MSMAW_RS15520	COG5012	cobalamin binding
MSMAW_RS15535	COG5012	cobalamin binding
MSMAW_RS15550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSMAW_RS15570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSMAW_RS15575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSMAW_RS15580	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MSMAW_RS15610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MSMAW_RS15645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSMAW_RS15690	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSMAW_RS15695	COG2239	Acts as a magnesium transporter
MSMAW_RS15710	COG0723	plastoquinol--plastocyanin reductase activity
MSMAW_RS15710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MSMAW_RS15755	COG5012	cobalamin binding
MSMAW_RS15820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MSMAW_RS15840	COG0577	efflux transmembrane transporter activity
MSMAW_RS15855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSMAW_RS15885	COG1830	Aldolase
MSMAW_RS15900	COG0523	cobalamin synthesis protein
MSMAW_RS15925	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MSMAW_RS15930	COG1691	(AIR) carboxylase
MSMAW_RS15955	COG0528	UMP kinase activity
MSMAW_RS15965	COG0577	efflux transmembrane transporter activity
MSMAW_RS15965	COG1136	(ABC) transporter
MSMAW_RS15970	COG1136	(ABC) transporter
MSMAW_RS15975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSMAW_RS16020	COG0428	transporter
MSMAW_RS16055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MSMAW_RS16090	COG1733	regulation of RNA biosynthetic process
MSMAW_RS16115	COG2249	NAD(P)H dehydrogenase (quinone) activity
MSMAW_RS16120	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSMAW_RS16130	COG3842	ATPase activity
MSMAW_RS16175	COG0243	molybdopterin cofactor binding
MSMAW_RS16190	COG1229	Formylmethanofuran dehydrogenase subunit A
MSMAW_RS16205	COG3842	ATPase activity
MSMAW_RS16210	COG4662	Binding-protein-dependent transport system inner membrane component
MSMAW_RS16275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSMAW_RS16320	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSMAW_RS16340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSMAW_RS16345	COG0235	Class ii aldolase
MSMAW_RS16360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSMAW_RS16365	COG0714	Associated with various cellular activities
MSMAW_RS16370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MSMAW_RS16385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MSMAW_RS16390	COG0372	Belongs to the citrate synthase family
MSMAW_RS16415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSMAW_RS16420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSMAW_RS16425	COG1606	tRNA processing
MSMAW_RS16430	COG1247	-acetyltransferase
MSMAW_RS16445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSMAW_RS16500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSMAW_RS16505	COG0131	Imidazoleglycerol-phosphate dehydratase
MSMAW_RS16510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSMAW_RS16515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSMAW_RS16520	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSMAW_RS16545	COG0024	Methionine aminopeptidase
MSMAW_RS16565	COG0101	tRNA pseudouridine synthase activity
MSMAW_RS16590	COG0066	3-isopropylmalate dehydratase activity
MSMAW_RS16595	COG0473	3-isopropylmalate dehydrogenase activity
MSMAW_RS16605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS16635	COG4279	zinc finger
MSMAW_RS16640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSMAW_RS16645	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSMAW_RS16660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS16665	COG0535	radical SAM domain protein
MSMAW_RS16710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSMAW_RS16730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSMAW_RS16735	COG1584	GPR1 FUN34 yaaH family protein
MSMAW_RS16745	COG0423	glycine-tRNA ligase activity
MSMAW_RS16750	COG0322	excinuclease ABC activity
MSMAW_RS16770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSMAW_RS16785	COG0443	Heat shock 70 kDa protein
MSMAW_RS16800	COG0459	protein refolding
MSMAW_RS16820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MSMAW_RS16860	COG0688	phosphatidylethanolamine metabolic process
MSMAW_RS16865	COG1183	phosphatidylcholine synthase activity
MSMAW_RS16875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSMAW_RS16880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSMAW_RS16940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSMAW_RS16950	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSMAW_RS16960	COG0071	Belongs to the small heat shock protein (HSP20) family
MSMAW_RS16975	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MSMAW_RS16975	COG0778	Nitroreductase
MSMAW_RS16990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSMAW_RS16995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSMAW_RS17035	COG0531	amino acid
MSMAW_RS17050	COG5012	cobalamin binding
MSMAW_RS17055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSMAW_RS17065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSMAW_RS17080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MSMAW_RS17085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSMAW_RS17100	COG1342	Belongs to the UPF0251 family
MSMAW_RS17110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSMAW_RS17110	COG0731	radical SAM domain protein
MSMAW_RS17140	COG0589	response to stress
MSMAW_RS17145	COG0589	response to stress
MSMAW_RS17185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MSMAW_RS17190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSMAW_RS17205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSMAW_RS17210	COG1260	myo-inositol-1-phosphate synthase
MSMAW_RS17230	COG0602	queuosine metabolic process
MSMAW_RS17235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSMAW_RS17255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSMAW_RS17270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS17275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS17280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS17285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSMAW_RS17325	COG0018	arginyl-trna synthetase
MSMAW_RS17365	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSMAW_RS17370	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSMAW_RS17390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MSMAW_RS17395	COG1121	(ABC) transporter
MSMAW_RS17410	COG2610	gluconate transmembrane transporter activity
MSMAW_RS17420	COG0840	transmembrane signaling receptor activity
MSMAW_RS17425	COG0784	Response regulator, receiver
MSMAW_RS17430	COG2201	protein-glutamate methylesterase activity
MSMAW_RS17435	COG2201	protein-glutamate methylesterase activity
MSMAW_RS17450	COG2198	Histidine kinase
MSMAW_RS17450	COG0643	Histidine kinase
MSMAW_RS17455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSMAW_RS17465	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSMAW_RS17470	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSMAW_RS17490	COG0076	glutamate decarboxylase activity
MSMAW_RS17495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSMAW_RS17515	COG1216	Glycosyl transferase, family 2
MSMAW_RS17520	COG1215	transferase activity, transferring glycosyl groups
MSMAW_RS17575	COG3920	Histidine kinase
MSMAW_RS17595	COG5002	protein histidine kinase activity
MSMAW_RS17640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MSMAW_RS17740	COG1742	UPF0060 membrane protein
MSMAW_RS17805	COG1598	PFAM Uncharacterised protein family UPF0150
MSMAW_RS17885	COG1773	rubredoxin
MSMAW_RS17985	COG4251	negative regulation of phosphorylation
MSMAW_RS18030	COG2205	protein histidine kinase activity
MSMAW_RS18185	COG0589	response to stress