locus-tag	class	description
MSSAC_RS00100	COG0517	IMP dehydrogenase activity
MSSAC_RS00100	COG0516	GMP reductase activity
MSSAC_RS00105	COG0617	tRNA 3'-terminal CCA addition
MSSAC_RS00105	COG0517	IMP dehydrogenase activity
MSSAC_RS00105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MSSAC_RS00125	COG0517	IMP dehydrogenase activity
MSSAC_RS00145	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MSSAC_RS00150	COG0430	RNA-3'-phosphate cyclase activity
MSSAC_RS00155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSAC_RS00195	COG0277	FAD linked oxidase domain protein
MSSAC_RS00200	COG0247	lactate metabolic process
MSSAC_RS00200	COG2181	nitrate reductase activity
MSSAC_RS00220	COG2814	Major facilitator Superfamily
MSSAC_RS00225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS00240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSSAC_RS00245	COG0084	hydrolase, TatD family'
MSSAC_RS00250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSAC_RS00280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSSAC_RS00285	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSSAC_RS00295	COG1120	ATPase activity
MSSAC_RS00300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS00320	COG0747	negative chemotaxis
MSSAC_RS00330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS00335	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS00340	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS00350	COG0287	Prephenate dehydrogenase
MSSAC_RS00350	COG1605	Chorismate mutase
MSSAC_RS00355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSSAC_RS00360	COG0710	3-dehydroquinate dehydratase activity
MSSAC_RS00365	COG1465	3-dehydroquinate synthase
MSSAC_RS00370	COG1830	Aldolase
MSSAC_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
MSSAC_RS00375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSSAC_RS00380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSSAC_RS00415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSSAC_RS00445	COG0322	excinuclease ABC activity
MSSAC_RS00450	COG0423	glycine-tRNA ligase activity
MSSAC_RS00495	COG1584	GPR1 FUN34 yaaH family protein
MSSAC_RS00500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSSAC_RS00505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MSSAC_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
MSSAC_RS00550	COG0688	phosphatidylethanolamine metabolic process
MSSAC_RS00555	COG1183	phosphatidylcholine synthase activity
MSSAC_RS00565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSSAC_RS00570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSSAC_RS00630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSSAC_RS00640	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSSAC_RS00645	COG0071	Belongs to the small heat shock protein (HSP20) family
MSSAC_RS00655	COG0778	Nitroreductase
MSSAC_RS00655	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MSSAC_RS00665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSSAC_RS00670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSSAC_RS00690	COG0531	amino acid
MSSAC_RS00705	COG5012	cobalamin binding
MSSAC_RS00740	COG5012	cobalamin binding
MSSAC_RS00745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSAC_RS00790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSSAC_RS00805	COG1342	Belongs to the UPF0251 family
MSSAC_RS00820	COG0731	radical SAM domain protein
MSSAC_RS00820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSSAC_RS00825	COG1528	Iron-storage protein
MSSAC_RS00830	COG0589	response to stress
MSSAC_RS00885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSAC_RS00915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS00930	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSSAC_RS00940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSSAC_RS00945	COG4279	zinc finger
MSSAC_RS00975	COG1993	acr, cog1993
MSSAC_RS00980	COG0473	3-isopropylmalate dehydrogenase activity
MSSAC_RS00985	COG0066	3-isopropylmalate dehydratase activity
MSSAC_RS01010	COG0101	tRNA pseudouridine synthase activity
MSSAC_RS01015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS01020	COG3377	Domain of unknown function (DUF1805)
MSSAC_RS01145	COG4974	Belongs to the 'phage' integrase family
MSSAC_RS01165	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSSAC_RS01170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSSAC_RS01175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSSAC_RS01180	COG0131	Imidazoleglycerol-phosphate dehydratase
MSSAC_RS01185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSSAC_RS01245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSSAC_RS01255	COG1214	PFAM Peptidase M22, glycoprotease
MSSAC_RS01255	COG0456	acetyltransferase
MSSAC_RS01260	COG1606	tRNA processing
MSSAC_RS01265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSSAC_RS01270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSSAC_RS01295	COG0372	Belongs to the citrate synthase family
MSSAC_RS01300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MSSAC_RS01320	COG0714	Associated with various cellular activities
MSSAC_RS01325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSSAC_RS01365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MSSAC_RS01380	COG0235	Class ii aldolase
MSSAC_RS01385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSSAC_RS01405	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSSAC_RS01450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSSAC_RS01455	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSSAC_RS01460	COG4208	sulfate ABC transporter
MSSAC_RS01465	COG3842	ATPase activity
MSSAC_RS01565	COG2226	methyltransferase
MSSAC_RS01575	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS01580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS01585	COG0601	transmembrane transport
MSSAC_RS01590	COG0747	negative chemotaxis
MSSAC_RS01595	COG2226	methyltransferase
MSSAC_RS01615	COG1229	Formylmethanofuran dehydrogenase subunit A
MSSAC_RS01635	COG2968	Membrane
MSSAC_RS01670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSSAC_RS01675	COG0561	phosphatase activity
MSSAC_RS01690	COG3842	ATPase activity
MSSAC_RS01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
MSSAC_RS01730	COG1733	regulation of RNA biosynthetic process
MSSAC_RS01735	COG0534	Mate efflux family protein
MSSAC_RS01800	COG0428	transporter
MSSAC_RS01815	COG1122	ATPase activity
MSSAC_RS01825	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSSAC_RS01830	COG0310	cobalt ion transport
MSSAC_RS01880	COG1429	ligase activity, forming nitrogen-metal bonds
MSSAC_RS01900	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSSAC_RS01905	COG1136	(ABC) transporter
MSSAC_RS01920	COG1136	(ABC) transporter
MSSAC_RS01920	COG0577	efflux transmembrane transporter activity
MSSAC_RS01930	COG0528	UMP kinase activity
MSSAC_RS02000	COG0667	Aldo Keto reductase
MSSAC_RS02005	COG1691	(AIR) carboxylase
MSSAC_RS02010	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MSSAC_RS02055	COG0523	cobalamin synthesis protein
MSSAC_RS02075	COG1830	Aldolase
MSSAC_RS02095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSSAC_RS02100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSSAC_RS02110	COG0577	efflux transmembrane transporter activity
MSSAC_RS02135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MSSAC_RS02155	COG5012	cobalamin binding
MSSAC_RS02265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MSSAC_RS02270	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MSSAC_RS02270	COG0456	acetyltransferase
MSSAC_RS02370	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MSSAC_RS02375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSSAC_RS02380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSSAC_RS02390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSSAC_RS02400	COG5012	cobalamin binding
MSSAC_RS02415	COG5012	cobalamin binding
MSSAC_RS02455	COG3613	nucleoside 2-deoxyribosyltransferase
MSSAC_RS02460	COG0826	peptidase U32
MSSAC_RS02475	COG0107	imidazoleglycerol-phosphate synthase activity
MSSAC_RS02485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSSAC_RS02505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSSAC_RS02505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSSAC_RS02510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSSAC_RS02515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSSAC_RS02605	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS02680	COG0535	radical SAM domain protein
MSSAC_RS02690	COG1522	sequence-specific DNA binding
MSSAC_RS02695	COG1648	precorrin-2 dehydrogenase activity
MSSAC_RS02695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSSAC_RS02700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSSAC_RS02705	COG0113	porphobilinogen synthase activity
MSSAC_RS02715	COG0181	hydroxymethylbilane synthase activity
MSSAC_RS02720	COG0167	dihydroorotate dehydrogenase activity
MSSAC_RS02725	COG0543	2 iron, 2 sulfur cluster binding
MSSAC_RS02730	COG0179	Fumarylacetoacetate (FAA) hydrolase
MSSAC_RS02760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MSSAC_RS02775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSSAC_RS02780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSSAC_RS02800	COG0052	Belongs to the universal ribosomal protein uS2 family
MSSAC_RS02805	COG1355	regulation of microtubule-based process
MSSAC_RS02810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MSSAC_RS02815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSSAC_RS02820	COG1304	FMN binding
MSSAC_RS02840	COG0574	Belongs to the PEP-utilizing enzyme family
MSSAC_RS02840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSSAC_RS02875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSSAC_RS02880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSSAC_RS02905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MSSAC_RS02915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MSSAC_RS03005	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSAC_RS03015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSSAC_RS03020	COG0459	protein refolding
MSSAC_RS03055	COG1592	Rubrerythrin
MSSAC_RS03080	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSAC_RS03115	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MSSAC_RS03140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MSSAC_RS03145	COG1477	protein flavinylation
MSSAC_RS03160	COG4656	Part of a membrane complex involved in electron transport
MSSAC_RS03170	COG4659	FMN binding
MSSAC_RS03175	COG4660	Part of a membrane complex involved in electron transport
MSSAC_RS03180	COG4657	Part of a membrane complex involved in electron transport
MSSAC_RS03185	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSAC_RS03185	COG2878	Part of a membrane complex involved in electron transport
MSSAC_RS03200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MSSAC_RS03210	COG2255	four-way junction helicase activity
MSSAC_RS03235	COG5016	pyruvate
MSSAC_RS03235	COG0511	ligase activity, forming carbon-carbon bonds
MSSAC_RS03240	COG0439	Biotin carboxylase
MSSAC_RS03245	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSSAC_RS03245	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSSAC_RS03290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSAC_RS03305	COG2181	nitrate reductase activity
MSSAC_RS03305	COG0247	lactate metabolic process
MSSAC_RS03320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MSSAC_RS03325	COG2081	HI0933 family
MSSAC_RS03350	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS03355	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS03375	COG0747	negative chemotaxis
MSSAC_RS03465	COG0163	prenyltransferase activity
MSSAC_RS03475	COG1078	dGTPase activity
MSSAC_RS03480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MSSAC_RS03490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSSAC_RS03510	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSAC_RS03545	COG1796	DNA polymerase
MSSAC_RS03545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSSAC_RS03550	COG1793	dna ligase
MSSAC_RS03560	COG3328	transposase activity
MSSAC_RS03600	COG1846	Transcriptional regulator
MSSAC_RS03610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSAC_RS03620	COG0424	maF-like protein
MSSAC_RS03625	COG0215	cysteine-tRNA ligase activity
MSSAC_RS03640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSSAC_RS03650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MSSAC_RS03665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSSAC_RS03670	COG2205	protein histidine kinase activity
MSSAC_RS03685	COG1201	RNA secondary structure unwinding
MSSAC_RS03735	COG2226	methyltransferase
MSSAC_RS03755	COG1247	-acetyltransferase
MSSAC_RS03780	COG0697	spore germination
MSSAC_RS03800	COG1739	Uncharacterized protein family UPF0029
MSSAC_RS03830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MSSAC_RS03835	COG2235	arginine
MSSAC_RS03865	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS03925	COG0822	iron-sulfur transferase activity
MSSAC_RS03930	COG1104	cysteine desulfurase activity
MSSAC_RS03935	COG2210	Belongs to the sulfur carrier protein TusA family
MSSAC_RS03940	COG0425	Belongs to the sulfur carrier protein TusA family
MSSAC_RS03945	COG0537	adenosine 5'-monophosphoramidase activity
MSSAC_RS03965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSSAC_RS03985	COG0039	L-malate dehydrogenase activity
MSSAC_RS04045	COG1229	Formylmethanofuran dehydrogenase subunit A
MSSAC_RS04050	COG3383	formate dehydrogenase (NAD+) activity
MSSAC_RS04055	COG0243	molybdopterin cofactor binding
MSSAC_RS04065	COG0747	negative chemotaxis
MSSAC_RS04070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MSSAC_RS04075	COG0601	transmembrane transport
MSSAC_RS04090	COG1131	(ABC) transporter
MSSAC_RS04095	COG0842	Transport permease protein
MSSAC_RS04140	COG0456	acetyltransferase
MSSAC_RS04140	COG1846	Transcriptional regulator
MSSAC_RS04150	COG0523	cobalamin synthesis protein
MSSAC_RS04165	COG5012	cobalamin binding
MSSAC_RS04205	COG1131	(ABC) transporter
MSSAC_RS04210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSAC_RS04215	COG1122	ATPase activity
MSSAC_RS04255	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS04260	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS04265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS04285	COG0747	negative chemotaxis
MSSAC_RS04295	COG0417	DNA replication proofreading
MSSAC_RS04305	COG0573	inorganic phosphate transmembrane transporter activity
MSSAC_RS04310	COG0581	inorganic phosphate transmembrane transporter activity
MSSAC_RS04315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSSAC_RS04325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MSSAC_RS04330	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSAC_RS04365	COG0316	Belongs to the HesB IscA family
MSSAC_RS04380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSSAC_RS04445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSSAC_RS04475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSSAC_RS04500	COG1522	sequence-specific DNA binding
MSSAC_RS04505	COG0436	Aminotransferase
MSSAC_RS04530	COG0719	Fe-S assembly protein
MSSAC_RS04530	COG1372	Participates in initiation and elongation during chromosome replication
MSSAC_RS04535	COG0396	ATPase activity
MSSAC_RS04540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSSAC_RS04545	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MSSAC_RS04555	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSSAC_RS04560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSSAC_RS04565	COG0124	histidyl-tRNA synthetase
MSSAC_RS04595	COG1120	ATPase activity
MSSAC_RS04600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS04625	COG0157	Belongs to the NadC ModD family
MSSAC_RS04640	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MSSAC_RS04645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSSAC_RS04655	COG0109	protoheme IX farnesyltransferase activity
MSSAC_RS04660	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSSAC_RS04665	COG1458	PINc domain ribonuclease
MSSAC_RS04675	COG3118	belongs to the thioredoxin family
MSSAC_RS04680	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSSAC_RS04685	COG0284	orotidine-5'-phosphate decarboxylase activity
MSSAC_RS04720	COG0659	secondary active sulfate transmembrane transporter activity
MSSAC_RS04805	COG1598	PFAM Uncharacterised protein family UPF0150
MSSAC_RS05055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MSSAC_RS05065	COG1047	Peptidyl-prolyl cis-trans
MSSAC_RS05115	COG1115	amino acid carrier protein
MSSAC_RS05130	COG1136	(ABC) transporter
MSSAC_RS05145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSAC_RS05155	COG3259	Nickel-dependent hydrogenase
MSSAC_RS05175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MSSAC_RS05180	COG0735	belongs to the Fur family
MSSAC_RS05185	COG3875	lactate racemase activity
MSSAC_RS05190	COG3875	lactate racemase activity
MSSAC_RS05210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MSSAC_RS05400	COG4397	Mu-like prophage major head subunit gpT
MSSAC_RS05505	COG4974	Belongs to the 'phage' integrase family
MSSAC_RS05565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSAC_RS05575	COG0587	DNA-directed DNA polymerase activity
MSSAC_RS05580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSSAC_RS05635	COG1418	mRNA catabolic process
MSSAC_RS05655	COG0402	S-adenosylhomocysteine deaminase activity
MSSAC_RS05660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSSAC_RS05665	COG4191	Histidine kinase
MSSAC_RS05675	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS05690	COG1136	(ABC) transporter
MSSAC_RS05695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSSAC_RS05705	COG4251	negative regulation of phosphorylation
MSSAC_RS05710	COG0784	Response regulator, receiver
MSSAC_RS05715	COG0784	Response regulator, receiver
MSSAC_RS05735	COG0085	RNA polymerase activity
MSSAC_RS05740	COG0085	RNA polymerase activity
MSSAC_RS05745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSSAC_RS05750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSSAC_RS05770	COG0049	tRNA binding
MSSAC_RS05775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MSSAC_RS05780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSSAC_RS05785	COG0051	transcription antitermination factor activity, RNA binding
MSSAC_RS05805	COG0747	negative chemotaxis
MSSAC_RS05815	COG0747	negative chemotaxis
MSSAC_RS05820	COG2226	methyltransferase
MSSAC_RS05825	COG0601	transmembrane transport
MSSAC_RS05830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS05835	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS05850	COG3585	molybdate ion transport
MSSAC_RS05860	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS05880	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSSAC_RS05885	COG4149	molybdate abc transporter
MSSAC_RS05890	COG3842	ATPase activity
MSSAC_RS05935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSAC_RS05940	COG1733	regulation of RNA biosynthetic process
MSSAC_RS05945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSAC_RS05955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MSSAC_RS05965	COG1136	(ABC) transporter
MSSAC_RS06035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSSAC_RS06040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSSAC_RS06060	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSSAC_RS06085	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSAC_RS06090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSSAC_RS06100	COG0318	PFAM AMP-dependent synthetase and ligase
MSSAC_RS06140	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS06180	COG1846	Transcriptional regulator
MSSAC_RS06200	COG2813	Specifically methylates the guanine in position
MSSAC_RS06205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS06220	COG1120	ATPase activity
MSSAC_RS06225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS06230	COG2226	methyltransferase
MSSAC_RS06285	COG3830	Belongs to the UPF0237 family
MSSAC_RS06290	COG2848	UPF0210 protein
MSSAC_RS06320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSSAC_RS06340	COG0714	Associated with various cellular activities
MSSAC_RS06380	COG0662	Cupin 2, conserved barrel domain protein
MSSAC_RS06385	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS06390	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS06395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS06415	COG1120	ATPase activity
MSSAC_RS06420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS06475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MSSAC_RS06485	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSSAC_RS06510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSSAC_RS06540	COG2205	protein histidine kinase activity
MSSAC_RS06540	COG2202	Pas domain
MSSAC_RS06555	COG1494	fructose-1,6-bisphosphatase
MSSAC_RS06560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSSAC_RS06585	COG1592	Rubrerythrin
MSSAC_RS06595	COG1401	restriction endodeoxyribonuclease activity
MSSAC_RS06605	COG0420	3'-5' exonuclease activity
MSSAC_RS06610	COG1196	nuclear chromosome segregation
MSSAC_RS06660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MSSAC_RS06665	COG0315	cyclic pyranopterin monophosphate synthase activity
MSSAC_RS06675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSSAC_RS06675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSSAC_RS06690	COG0463	Glycosyl transferase, family 2
MSSAC_RS06715	COG0534	Mate efflux family protein
MSSAC_RS06770	COG3158	transport of potassium into the cell
MSSAC_RS06790	COG0577	efflux transmembrane transporter activity
MSSAC_RS06790	COG1136	(ABC) transporter
MSSAC_RS06800	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS06870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSAC_RS06975	COG5012	cobalamin binding
MSSAC_RS07015	COG0512	Glutamine amidotransferase of anthranilate synthase
MSSAC_RS07015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSSAC_RS07025	COG0135	phosphoribosylanthranilate isomerase activity
MSSAC_RS07030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSSAC_RS07035	COG0159	tryptophan synthase activity
MSSAC_RS07040	COG0133	tryptophan synthase activity
MSSAC_RS07065	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS07105	COG4804	nuclease activity
MSSAC_RS07115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MSSAC_RS07150	COG1136	(ABC) transporter
MSSAC_RS07165	COG0148	phosphopyruvate hydratase activity
MSSAC_RS07185	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS07240	COG0546	phosphoglycolate phosphatase activity
MSSAC_RS07250	COG0745	RESPONSE REGULATOR receiver
MSSAC_RS07260	COG0492	ferredoxin-NADP+ reductase activity
MSSAC_RS07295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSSAC_RS07310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSSAC_RS07335	COG1160	GTP binding
MSSAC_RS07350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSSAC_RS07355	COG0436	Aminotransferase
MSSAC_RS07365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSSAC_RS07375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSSAC_RS07375	COG0140	phosphoribosyl-ATP diphosphatase activity
MSSAC_RS07390	COG0864	Transcriptional regulator
MSSAC_RS07400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MSSAC_RS07455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MSSAC_RS07500	COG1122	ATPase activity
MSSAC_RS07505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSAC_RS07520	COG0318	PFAM AMP-dependent synthetase and ligase
MSSAC_RS07570	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS07610	COG1007	ATP synthesis coupled electron transport
MSSAC_RS07615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSAC_RS07625	COG0713	ATP synthesis coupled electron transport
MSSAC_RS07640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSAC_RS07650	COG0649	NAD binding
MSSAC_RS07655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSAC_RS07655	COG0649	NAD binding
MSSAC_RS07660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSAC_RS07665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSAC_RS07685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSSAC_RS07695	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSSAC_RS07735	COG0569	domain protein
MSSAC_RS07750	COG0484	heat shock protein binding
MSSAC_RS07755	COG0443	Heat shock 70 kDa protein
MSSAC_RS07760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MSSAC_RS07815	COG0745	RESPONSE REGULATOR receiver
MSSAC_RS07820	COG0301	tRNA thio-modification
MSSAC_RS07835	COG0589	response to stress
MSSAC_RS07865	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MSSAC_RS07880	COG3174	membrane
MSSAC_RS07915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSSAC_RS07920	COG2890	protein-(glutamine-N5) methyltransferase activity
MSSAC_RS07925	COG2816	NAD+ diphosphatase activity
MSSAC_RS07930	COG1309	transcriptional regulator
MSSAC_RS08010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS08025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSAC_RS08045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSSAC_RS08050	COG0017	Asparaginyl-tRNA synthetase
MSSAC_RS08065	COG1045	serine acetyltransferase
MSSAC_RS08070	COG0352	thiamine-phosphate diphosphorylase activity
MSSAC_RS08150	COG1132	(ABC) transporter
MSSAC_RS08190	COG0306	phosphate transporter
MSSAC_RS08250	COG5012	cobalamin binding
MSSAC_RS08260	COG2032	superoxide dismutase activity
MSSAC_RS08285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSAC_RS08295	COG0732	type I restriction modification DNA specificity domain
MSSAC_RS08300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSAC_RS08340	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSSAC_RS08355	COG0393	Putative heavy-metal-binding
MSSAC_RS08365	COG0426	domain, Protein
MSSAC_RS08370	COG0531	amino acid
MSSAC_RS08385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MSSAC_RS08400	COG5012	cobalamin binding
MSSAC_RS08500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSSAC_RS08505	COG0151	Belongs to the GarS family
MSSAC_RS08515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSSAC_RS08530	COG1138	Cytochrome C-type biogenesis protein
MSSAC_RS08625	COG1067	ATP-dependent peptidase activity
MSSAC_RS08625	COG0470	DNA polymerase III
MSSAC_RS08635	COG0312	modulator of DNA gyrase
MSSAC_RS08650	COG0589	response to stress
MSSAC_RS08665	COG2835	tetraacyldisaccharide 4'-kinase activity
MSSAC_RS08675	COG0504	CTP synthase activity
MSSAC_RS08730	COG1136	(ABC) transporter
MSSAC_RS08740	COG0577	efflux transmembrane transporter activity
MSSAC_RS08740	COG1136	(ABC) transporter
MSSAC_RS08755	COG2205	protein histidine kinase activity
MSSAC_RS08765	COG2205	protein histidine kinase activity
MSSAC_RS08805	COG0058	SHG alpha-glucan phosphorylase activity
MSSAC_RS08845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSSAC_RS08855	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSSAC_RS08865	COG2814	Major facilitator Superfamily
MSSAC_RS08925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSSAC_RS08930	COG0589	response to stress
MSSAC_RS08940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSSAC_RS08980	COG2326	polyphosphate kinase activity
MSSAC_RS08985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSAC_RS08990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSAC_RS09000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MSSAC_RS09030	COG3848	Pyruvate phosphate dikinase
MSSAC_RS09030	COG0574	Belongs to the PEP-utilizing enzyme family
MSSAC_RS09115	COG4717	serine-type aminopeptidase activity
MSSAC_RS09120	COG0420	3'-5' exonuclease activity
MSSAC_RS09135	COG0210	DNA helicase
MSSAC_RS09140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MSSAC_RS09165	COG1324	tolerance protein
MSSAC_RS09185	COG1131	(ABC) transporter
MSSAC_RS09205	COG0534	Mate efflux family protein
MSSAC_RS09210	COG0585	pseudouridine synthase activity
MSSAC_RS09225	COG0189	ligase activity
MSSAC_RS09230	COG0822	iron-sulfur transferase activity
MSSAC_RS09270	COG3093	addiction module antidote protein HigA
MSSAC_RS09325	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSSAC_RS09340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSSAC_RS09375	COG1704	LemA family
MSSAC_RS09380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSSAC_RS09390	COG0574	Belongs to the PEP-utilizing enzyme family
MSSAC_RS09390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSSAC_RS09400	COG0126	phosphoglycerate kinase activity
MSSAC_RS09410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSSAC_RS09410	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS09420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSSAC_RS09430	COG1111	helicase
MSSAC_RS09430	COG1205	dead DEAH box helicase
MSSAC_RS09440	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MSSAC_RS09500	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSSAC_RS09510	COG0598	Magnesium transport protein CorA
MSSAC_RS09535	COG3590	peptidase
MSSAC_RS09560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSSAC_RS09595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSSAC_RS09680	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS09685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSSAC_RS09695	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS09740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSAC_RS09760	COG0517	IMP dehydrogenase activity
MSSAC_RS09760	COG4175	Glycine betaine
MSSAC_RS09765	COG0505	Belongs to the CarA family
MSSAC_RS09770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSSAC_RS09775	COG0137	argininosuccinate synthase activity
MSSAC_RS09800	COG2361	Protein of unknown function DUF86
MSSAC_RS09890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MSSAC_RS09895	COG2873	o-acetylhomoserine
MSSAC_RS09900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSSAC_RS09905	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS09915	COG0822	iron-sulfur transferase activity
MSSAC_RS09930	COG4145	pantothenate transmembrane transporter activity
MSSAC_RS09935	COG0252	asparaginase activity
MSSAC_RS09940	COG0165	Argininosuccinate lyase
MSSAC_RS10000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSSAC_RS10025	COG0641	radical SAM
MSSAC_RS10055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSSAC_RS10060	COG0556	nucleotide-excision repair
MSSAC_RS10065	COG0322	excinuclease ABC activity
MSSAC_RS10070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MSSAC_RS10080	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSSAC_RS10085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSAC_RS10110	COG1373	ATPase (AAA superfamily
MSSAC_RS10250	COG0577	efflux transmembrane transporter activity
MSSAC_RS10265	COG1122	ATPase activity
MSSAC_RS10270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSAC_RS10290	COG1136	(ABC) transporter
MSSAC_RS10420	COG3291	Pkd domain containing protein
MSSAC_RS10425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSAC_RS10445	COG1215	transferase activity, transferring glycosyl groups
MSSAC_RS10450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MSSAC_RS10475	COG1216	Glycosyl transferase, family 2
MSSAC_RS10500	COG1083	cytidylyl-transferase
MSSAC_RS10505	COG2089	acid synthase
MSSAC_RS10510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MSSAC_RS10515	COG0110	maltose O-acetyltransferase activity
MSSAC_RS10520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSSAC_RS10525	COG1086	Polysaccharide biosynthesis protein
MSSAC_RS10570	COG0668	transmembrane transport
MSSAC_RS10600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MSSAC_RS10605	COG0187	DNA topoisomerase II activity
MSSAC_RS10690	COG0708	Exodeoxyribonuclease III
MSSAC_RS10710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS10720	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS10750	COG0667	Aldo Keto reductase
MSSAC_RS10785	COG0534	Mate efflux family protein
MSSAC_RS10890	COG0105	UTP biosynthetic process
MSSAC_RS10985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSAC_RS11010	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSSAC_RS11030	COG1131	(ABC) transporter
MSSAC_RS11040	COG0501	Belongs to the peptidase M48B family
MSSAC_RS11060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSAC_RS11085	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSSAC_RS11155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSAC_RS11230	COG1045	serine acetyltransferase
MSSAC_RS11260	COG1051	belongs to the nudix hydrolase family
MSSAC_RS11275	COG1120	ATPase activity
MSSAC_RS11280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS11350	COG2239	Acts as a magnesium transporter
MSSAC_RS11355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MSSAC_RS11355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSSAC_RS11360	COG0436	Aminotransferase
MSSAC_RS11365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSSAC_RS11375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MSSAC_RS11385	COG2226	methyltransferase
MSSAC_RS11435	COG2003	Belongs to the UPF0758 family
MSSAC_RS11445	COG0746	molybdenum cofactor guanylyltransferase activity
MSSAC_RS11465	COG0037	tRNA processing
MSSAC_RS11515	COG0367	asparagine synthase
MSSAC_RS11530	COG0047	phosphoribosylformylglycinamidine synthase activity
MSSAC_RS11550	COG0028	Belongs to the TPP enzyme family
MSSAC_RS11555	COG0072	phenylalanine-tRNA ligase activity
MSSAC_RS11590	COG0076	glutamate decarboxylase activity
MSSAC_RS11645	COG1337	RAMP superfamily
MSSAC_RS11725	COG0671	phosphoesterase, PA-phosphatase related
MSSAC_RS11745	COG0534	Mate efflux family protein
MSSAC_RS11760	COG0531	amino acid
MSSAC_RS11775	COG1295	ribonuclease BN
MSSAC_RS11800	COG1136	(ABC) transporter
MSSAC_RS11810	COG1136	(ABC) transporter
MSSAC_RS11810	COG0577	efflux transmembrane transporter activity
MSSAC_RS11820	COG3431	PFAM Phosphate-starvation-inducible E
MSSAC_RS11885	COG1260	myo-inositol-1-phosphate synthase
MSSAC_RS11920	COG0601	transmembrane transport
MSSAC_RS11930	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS11950	COG0583	DNA-binding transcription factor activity
MSSAC_RS11965	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MSSAC_RS12025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSSAC_RS12050	COG1131	(ABC) transporter
MSSAC_RS12075	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MSSAC_RS12150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MSSAC_RS12155	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MSSAC_RS12165	COG0671	phosphoesterase, PA-phosphatase related
MSSAC_RS12175	COG1506	peptidase
MSSAC_RS12180	COG1988	membrane-bound metal-dependent
MSSAC_RS12210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MSSAC_RS12220	COG1846	Transcriptional regulator
MSSAC_RS12230	COG0628	permease
MSSAC_RS12235	COG1131	(ABC) transporter
MSSAC_RS12245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSSAC_RS12295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSSAC_RS12305	COG0590	tRNA wobble adenosine to inosine editing
MSSAC_RS12310	COG0574	Belongs to the PEP-utilizing enzyme family
MSSAC_RS12310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSSAC_RS12325	COG2095	MarC family integral membrane protein
MSSAC_RS12415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSSAC_RS12440	COG5012	cobalamin binding
MSSAC_RS12485	COG0745	RESPONSE REGULATOR receiver
MSSAC_RS12490	COG0745	RESPONSE REGULATOR receiver
MSSAC_RS12495	COG2326	polyphosphate kinase activity
MSSAC_RS12615	COG2003	Belongs to the UPF0758 family
MSSAC_RS12650	COG1196	nuclear chromosome segregation
MSSAC_RS12675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSAC_RS12725	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS12730	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSSAC_RS12795	COG0281	malic enzyme
MSSAC_RS12805	COG2226	methyltransferase
MSSAC_RS12870	COG2814	Major facilitator Superfamily
MSSAC_RS12890	COG1836	PFAM Integral membrane protein DUF92
MSSAC_RS12895	COG2221	Nitrite and sulphite reductase 4Fe-4S
MSSAC_RS12905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MSSAC_RS12910	COG0668	transmembrane transport
MSSAC_RS12985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSSAC_RS12995	COG4555	ABC transporter
MSSAC_RS13000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSSAC_RS13040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSSAC_RS13055	COG2226	methyltransferase
MSSAC_RS13065	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS13080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSSAC_RS13090	COG0588	phosphoglycerate mutase activity
MSSAC_RS13100	COG2151	metal-sulfur cluster biosynthetic enzyme
MSSAC_RS13180	COG0667	Aldo Keto reductase
MSSAC_RS13290	COG1301	dicarboxylic acid transport
MSSAC_RS13300	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSAC_RS13435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSAC_RS13440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSSAC_RS13450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSSAC_RS13465	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS13575	COG1120	ATPase activity
MSSAC_RS13580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS13605	COG1254	Belongs to the acylphosphatase family
MSSAC_RS13635	COG0129	dihydroxy-acid dehydratase activity
MSSAC_RS13665	COG2871	sodium ion transport
MSSAC_RS13710	COG0628	permease
MSSAC_RS13740	COG3264	Mechanosensitive ion channel
MSSAC_RS13740	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MSSAC_RS13755	COG0628	permease
MSSAC_RS13760	COG0641	radical SAM
MSSAC_RS13765	COG3119	arylsulfatase activity
MSSAC_RS13795	COG2195	Cleaves the N-terminal amino acid of tripeptides
MSSAC_RS13845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSSAC_RS13855	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSSAC_RS13875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSSAC_RS13875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSAC_RS13890	COG0653	protein targeting
MSSAC_RS13900	COG0426	domain, Protein
MSSAC_RS13925	COG0129	dihydroxy-acid dehydratase activity
MSSAC_RS13935	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSSAC_RS13955	COG2255	four-way junction helicase activity
MSSAC_RS13970	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSSAC_RS13975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSAC_RS14010	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS14020	COG2205	protein histidine kinase activity
MSSAC_RS14035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSSAC_RS14155	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MSSAC_RS14180	COG1131	(ABC) transporter
MSSAC_RS14255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MSSAC_RS14260	COG0495	leucyl-tRNA aminoacylation
MSSAC_RS14275	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS14295	COG1858	cytochrome C peroxidase
MSSAC_RS14305	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS14305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSSAC_RS14335	COG3063	Type IV pilus biogenesis stability protein PilW
MSSAC_RS14375	COG1073	alpha beta
MSSAC_RS14410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MSSAC_RS14415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MSSAC_RS14420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MSSAC_RS14430	COG0356	it plays a direct role in the translocation of protons across the membrane
MSSAC_RS14450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MSSAC_RS14460	COG2153	protein acetylation
MSSAC_RS14480	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSSAC_RS14485	COG0569	domain protein
MSSAC_RS14500	COG4974	Belongs to the 'phage' integrase family
MSSAC_RS14605	COG4397	Mu-like prophage major head subunit gpT
MSSAC_RS14785	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS14810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSSAC_RS14810	COG4451	ribulose bisphosphate carboxylase, small
MSSAC_RS14845	COG0693	protein deglycase activity
MSSAC_RS14860	COG2205	protein histidine kinase activity
MSSAC_RS14865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSSAC_RS14875	COG1618	nucleotide phosphatase activity, acting on free nucleotides
MSSAC_RS14895	COG3264	Mechanosensitive ion channel
MSSAC_RS14895	COG1511	domain protein
MSSAC_RS14945	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MSSAC_RS14985	COG0688	phosphatidylethanolamine metabolic process
MSSAC_RS14995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MSSAC_RS15000	COG1012	belongs to the aldehyde dehydrogenase family
MSSAC_RS15005	COG2204	response regulator
MSSAC_RS15015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSSAC_RS15030	COG0589	response to stress
MSSAC_RS15040	COG1233	COG1233 Phytoene dehydrogenase and related
MSSAC_RS15175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSSAC_RS15180	COG1061	Type III restriction enzyme res subunit
MSSAC_RS15185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MSSAC_RS15210	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSAC_RS15220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSSAC_RS15335	COG1047	Peptidyl-prolyl cis-trans
MSSAC_RS15340	COG1047	Peptidyl-prolyl cis-trans
MSSAC_RS15345	COG1047	Peptidyl-prolyl cis-trans
MSSAC_RS15385	COG0714	Associated with various cellular activities
MSSAC_RS15400	COG0077	Prephenate dehydratase
MSSAC_RS15400	COG1605	Chorismate mutase
MSSAC_RS15430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSSAC_RS15475	COG0581	inorganic phosphate transmembrane transporter activity
MSSAC_RS15565	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS15570	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS15570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSSAC_RS15595	COG0840	transmembrane signaling receptor activity
MSSAC_RS15600	COG0835	chemotaxis
MSSAC_RS15610	COG2201	protein-glutamate methylesterase activity
MSSAC_RS15615	COG2201	protein-glutamate methylesterase activity
MSSAC_RS15620	COG2198	Histidine kinase
MSSAC_RS15620	COG0643	Histidine kinase
MSSAC_RS15625	COG1776	CheC inhibitor of MCP methylation
MSSAC_RS15630	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSSAC_RS15700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS15710	COG0747	negative chemotaxis
MSSAC_RS15715	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS15720	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS15750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MSSAC_RS15770	COG0535	radical SAM domain protein
MSSAC_RS15790	COG1234	tRNA 3'-trailer cleavage
MSSAC_RS15805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSAC_RS15835	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSAC_RS15855	COG2608	mercury ion transmembrane transporter activity
MSSAC_RS15865	COG1733	regulation of RNA biosynthetic process
MSSAC_RS15885	COG2217	Heavy metal translocating P-type atpase
MSSAC_RS15895	COG4895	conserved protein (DUF2196)
MSSAC_RS15920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS15925	COG2076	Multidrug Resistance protein
MSSAC_RS15955	COG0028	Belongs to the TPP enzyme family
MSSAC_RS15960	COG1012	belongs to the aldehyde dehydrogenase family
MSSAC_RS15975	COG0730	response to heat
MSSAC_RS15975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSSAC_RS15980	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSSAC_RS16000	COG0747	negative chemotaxis
MSSAC_RS16005	COG0601	transmembrane transport
MSSAC_RS16010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS16020	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS16035	COG1321	iron dependent repressor
MSSAC_RS16050	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSAC_RS16055	COG1132	(ABC) transporter
MSSAC_RS16060	COG1132	(ABC) transporter
MSSAC_RS16060	COG2375	cellular response to nickel ion
MSSAC_RS16075	COG1918	ferrous iron import across plasma membrane
MSSAC_RS16075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSSAC_RS16100	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MSSAC_RS16105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSSAC_RS16110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSSAC_RS16115	COG0805	protein transport
MSSAC_RS16120	COG0805	protein transport
MSSAC_RS16150	COG1945	arginine decarboxylase activity
MSSAC_RS16160	COG0145	ligase activity
MSSAC_RS16175	COG1451	nucleotide metabolic process
MSSAC_RS16220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSSAC_RS16225	COG1793	dna ligase
MSSAC_RS16230	COG0460	homoserine dehydrogenase
MSSAC_RS16285	COG0563	adenylate kinase activity
MSSAC_RS16290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MSSAC_RS16300	COG1131	(ABC) transporter
MSSAC_RS16310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSSAC_RS16315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSSAC_RS16345	COG0577	efflux transmembrane transporter activity
MSSAC_RS16345	COG1136	(ABC) transporter
MSSAC_RS16355	COG1136	(ABC) transporter
MSSAC_RS16360	COG0534	Mate efflux family protein
MSSAC_RS16390	COG0392	lysyltransferase activity
MSSAC_RS16390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MSSAC_RS16415	COG0826	peptidase U32
MSSAC_RS16420	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
MSSAC_RS16490	COG0561	phosphatase activity
MSSAC_RS16500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSSAC_RS16510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MSSAC_RS16525	COG2155	Conserved Protein
MSSAC_RS16530	COG1122	ATPase activity
MSSAC_RS16540	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSSAC_RS16545	COG0310	cobalt ion transport
MSSAC_RS16600	COG4804	nuclease activity
MSSAC_RS16620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSSAC_RS16625	COG0517	IMP dehydrogenase activity
MSSAC_RS16630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSSAC_RS16635	COG3613	nucleoside 2-deoxyribosyltransferase
MSSAC_RS16640	COG0456	acetyltransferase
MSSAC_RS16665	COG1136	(ABC) transporter
MSSAC_RS16665	COG0577	efflux transmembrane transporter activity
MSSAC_RS16705	COG0071	Belongs to the small heat shock protein (HSP20) family
MSSAC_RS16710	COG2814	Major facilitator Superfamily
MSSAC_RS16715	COG2078	PFAM AMMECR1 domain protein
MSSAC_RS16720	COG0126	phosphoglycerate kinase activity
MSSAC_RS16725	COG1573	uracil-dna glycosylase
MSSAC_RS16785	COG0045	succinate-CoA ligase (ADP-forming) activity
MSSAC_RS16785	COG1042	CoA-binding domain protein
MSSAC_RS16785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSSAC_RS16790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSSAC_RS16795	COG0280	phosphate acetyltransferase
MSSAC_RS16805	COG0038	chloride channel
MSSAC_RS16815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSAC_RS16830	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MSSAC_RS16835	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MSSAC_RS16855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MSSAC_RS16870	COG0298	carbon dioxide binding
MSSAC_RS16880	COG0375	protein maturation
MSSAC_RS16885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSSAC_RS16890	COG0309	Hydrogenase expression formation protein (HypE)
MSSAC_RS16900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSAC_RS16920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSSAC_RS16925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSSAC_RS16930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSSAC_RS16935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSSAC_RS16970	COG3118	belongs to the thioredoxin family
MSSAC_RS16995	COG1121	(ABC) transporter
MSSAC_RS17000	COG4581	dead DEAH box helicase
MSSAC_RS17020	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MSSAC_RS17025	COG0351	phosphomethylpyrimidine kinase
MSSAC_RS17040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSSAC_RS17045	COG0432	Pfam Uncharacterised protein family UPF0047
MSSAC_RS17055	COG0534	Mate efflux family protein
MSSAC_RS17180	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSSAC_RS17190	COG0588	phosphoglycerate mutase activity
MSSAC_RS17210	COG1945	arginine decarboxylase activity
MSSAC_RS17260	COG0530	calcium, potassium:sodium antiporter activity
MSSAC_RS17270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSSAC_RS17275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSSAC_RS17280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MSSAC_RS17345	COG0826	peptidase U32
MSSAC_RS17350	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSSAC_RS17365	COG0436	Aminotransferase
MSSAC_RS17445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSSAC_RS17450	COG0463	Glycosyl transferase, family 2
MSSAC_RS17455	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS17460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSSAC_RS17495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MSSAC_RS17500	COG1091	dTDP-4-dehydrorhamnose reductase activity
MSSAC_RS17525	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS17535	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSSAC_RS17585	COG1120	ATPase activity
MSSAC_RS17590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS17600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSSAC_RS17645	COG0347	Belongs to the P(II) protein family
MSSAC_RS17660	COG0347	Belongs to the P(II) protein family
MSSAC_RS17665	COG0347	Belongs to the P(II) protein family
MSSAC_RS17680	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MSSAC_RS17685	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MSSAC_RS17705	COG0066	3-isopropylmalate dehydratase activity
MSSAC_RS17835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSSAC_RS17845	COG0563	adenylate kinase activity
MSSAC_RS17865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSSAC_RS17890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSSAC_RS17900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MSSAC_RS17915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSSAC_RS17930	COG0255	Belongs to the universal ribosomal protein uL29 family
MSSAC_RS17935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSSAC_RS17940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MSSAC_RS17945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSSAC_RS17955	COG0089	rRNA binding
MSSAC_RS17960	COG0088	Forms part of the polypeptide exit tunnel
MSSAC_RS17965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSSAC_RS18000	COG0501	Belongs to the peptidase M48B family
MSSAC_RS18025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSSAC_RS18035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSSAC_RS18040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSSAC_RS18050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MSSAC_RS18055	COG1442	glycosyl transferase family 8
MSSAC_RS18055	COG1216	Glycosyl transferase, family 2
MSSAC_RS18085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MSSAC_RS18130	COG1342	Belongs to the UPF0251 family
MSSAC_RS18175	COG1294	oxidase, subunit
MSSAC_RS18180	COG1271	oxidase subunit
MSSAC_RS18185	COG0735	belongs to the Fur family
MSSAC_RS18195	COG1902	pentaerythritol trinitrate reductase activity
MSSAC_RS18210	COG2226	methyltransferase
MSSAC_RS18215	COG3328	transposase activity
MSSAC_RS18225	COG1122	ATPase activity
MSSAC_RS18290	COG1408	metallophosphoesterase
MSSAC_RS18295	COG0557	exoribonuclease II activity
MSSAC_RS18300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSAC_RS18335	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MSSAC_RS18340	COG1518	maintenance of DNA repeat elements
MSSAC_RS18405	COG3431	PFAM Phosphate-starvation-inducible E
MSSAC_RS18425	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSSAC_RS18465	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS18480	COG0371	Dehydrogenase
MSSAC_RS18515	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSAC_RS18570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSSAC_RS18575	COG1331	Highly conserved protein containing a thioredoxin domain
MSSAC_RS18600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MSSAC_RS18605	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSSAC_RS18610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSSAC_RS18640	COG2033	superoxide reductase activity
MSSAC_RS18665	COG0426	domain, Protein
MSSAC_RS18670	COG3527	Alpha-acetolactate decarboxylase
MSSAC_RS18680	COG0473	3-isopropylmalate dehydrogenase activity
MSSAC_RS18695	COG0066	3-isopropylmalate dehydratase activity
MSSAC_RS18720	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS18725	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS18795	COG0493	'glutamate synthase
MSSAC_RS18810	COG0778	Nitroreductase
MSSAC_RS18815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSSAC_RS18820	COG0440	acetolactate synthase activity
MSSAC_RS18825	COG0028	Belongs to the TPP enzyme family
MSSAC_RS18830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSAC_RS18840	COG1363	Peptidase, m42
MSSAC_RS18860	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSSAC_RS18925	COG1215	transferase activity, transferring glycosyl groups
MSSAC_RS18950	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MSSAC_RS18955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSSAC_RS18960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSSAC_RS18970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSSAC_RS18985	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSSAC_RS18995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSSAC_RS19000	COG2814	Major facilitator Superfamily
MSSAC_RS19025	COG0442	prolyl-tRNA aminoacylation
MSSAC_RS19030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSSAC_RS19085	COG0644	oxidoreductase
MSSAC_RS19090	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSSAC_RS19100	COG0347	Belongs to the P(II) protein family
MSSAC_RS19125	COG4149	molybdate abc transporter
MSSAC_RS19130	COG3842	ATPase activity
MSSAC_RS19140	COG2226	methyltransferase
MSSAC_RS19145	COG0747	negative chemotaxis
MSSAC_RS19150	COG0601	transmembrane transport
MSSAC_RS19155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS19195	COG2226	methyltransferase
MSSAC_RS19200	COG0347	Belongs to the P(II) protein family
MSSAC_RS19205	COG0004	ammonium transporteR
MSSAC_RS19210	COG0004	ammonium transporteR
MSSAC_RS19215	COG0640	Transcriptional regulator
MSSAC_RS19260	COG1120	ATPase activity
MSSAC_RS19265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS19315	COG0798	PFAM Bile acid sodium symporter
MSSAC_RS19350	COG0785	Cytochrome C biogenesis protein
MSSAC_RS19380	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS19390	COG0513	Belongs to the DEAD box helicase family
MSSAC_RS19400	COG1136	(ABC) transporter
MSSAC_RS19410	COG0577	efflux transmembrane transporter activity
MSSAC_RS19415	COG1136	(ABC) transporter
MSSAC_RS19425	COG2205	protein histidine kinase activity
MSSAC_RS19460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MSSAC_RS19475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSSAC_RS19480	COG4962	Type ii secretion system protein e
MSSAC_RS19495	COG0456	acetyltransferase
MSSAC_RS19500	COG1509	lysine 2,3-aminomutase activity
MSSAC_RS19515	COG1476	TRANSCRIPTIONal
MSSAC_RS19530	COG0010	Belongs to the arginase family
MSSAC_RS19550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSSAC_RS19550	COG5549	protein import
MSSAC_RS19590	COG1122	ATPase activity
MSSAC_RS19595	COG2217	Heavy metal translocating P-type atpase
MSSAC_RS19620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSSAC_RS19635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSSAC_RS19640	COG1584	GPR1 FUN34 yaaH family protein
MSSAC_RS19660	COG0138	bifunctional purine biosynthesis protein purh
MSSAC_RS19670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSSAC_RS19680	COG0310	cobalt ion transport
MSSAC_RS19705	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSAC_RS19710	COG1122	ATPase activity
MSSAC_RS19725	COG1122	ATPase activity
MSSAC_RS19735	COG0310	cobalt ion transport
MSSAC_RS19815	COG0183	Belongs to the thiolase family
MSSAC_RS19835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSSAC_RS19835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSSAC_RS19840	COG0616	signal peptide processing
MSSAC_RS19845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSSAC_RS19875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSSAC_RS19900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSSAC_RS19905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSAC_RS19910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSSAC_RS19910	COG0321	lipoyl(octanoyl) transferase activity
MSSAC_RS19930	COG2155	Conserved Protein
MSSAC_RS19935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSSAC_RS19965	COG0535	radical SAM domain protein
MSSAC_RS19980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSSAC_RS19985	COG0081	regulation of translation
MSSAC_RS19990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSSAC_RS20005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSSAC_RS20030	COG0473	3-isopropylmalate dehydrogenase activity
MSSAC_RS20035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSAC_RS20085	COG0785	Cytochrome C biogenesis protein
MSSAC_RS20095	COG4608	Belongs to the ABC transporter superfamily
MSSAC_RS20100	COG0444	Belongs to the ABC transporter superfamily
MSSAC_RS20105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSAC_RS20110	COG0601	transmembrane transport
MSSAC_RS20115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MSSAC_RS20120	COG2226	methyltransferase
MSSAC_RS20125	COG0747	negative chemotaxis
MSSAC_RS20130	COG0489	protein tyrosine kinase activity
MSSAC_RS20135	COG1342	Belongs to the UPF0251 family
MSSAC_RS20150	COG0489	protein tyrosine kinase activity
MSSAC_RS20175	COG2048	Heterodisulfide reductase, subunit B
MSSAC_RS20180	COG2181	nitrate reductase activity
MSSAC_RS20180	COG0247	lactate metabolic process
MSSAC_RS20200	COG0024	Methionine aminopeptidase
MSSAC_RS20265	COG0067	glutamate synthase
MSSAC_RS20280	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MSSAC_RS20305	COG0347	Belongs to the P(II) protein family
MSSAC_RS20310	COG0004	ammonium transporteR
MSSAC_RS20350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSSAC_RS20360	COG0602	queuosine metabolic process
MSSAC_RS20365	COG0720	synthase
MSSAC_RS20370	COG1433	Dinitrogenase iron-molybdenum cofactor
MSSAC_RS20370	COG0535	radical SAM domain protein
MSSAC_RS20380	COG2144	transferase activity, transferring acyl groups
MSSAC_RS20410	COG4106	trans-aconitate 2-methyltransferase activity
MSSAC_RS20430	COG1229	Formylmethanofuran dehydrogenase subunit A
MSSAC_RS20485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSAC_RS20490	COG5012	cobalamin binding
MSSAC_RS20505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MSSAC_RS20515	COG1394	ATPase activity, coupled to movement of substances
MSSAC_RS20520	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MSSAC_RS20525	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MSSAC_RS20550	COG1269	ATP hydrolysis coupled proton transport
MSSAC_RS20560	COG0535	radical SAM domain protein
MSSAC_RS20585	COG0671	phosphoesterase, PA-phosphatase related
MSSAC_RS20705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSSAC_RS20745	COG0552	protein localization to endoplasmic reticulum
MSSAC_RS20750	COG1983	PspC domain protein
MSSAC_RS20760	COG3272	Protein of unknown function (DUF1722)
MSSAC_RS20770	COG0450	alkyl hydroperoxide reductase
MSSAC_RS20775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MSSAC_RS20780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSSAC_RS20785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSSAC_RS20800	COG1872	DUF167
MSSAC_RS20805	COG0402	S-adenosylhomocysteine deaminase activity
MSSAC_RS20815	COG0517	IMP dehydrogenase activity
MSSAC_RS20830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSSAC_RS20835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSSAC_RS20840	COG0303	'Molybdopterin
MSSAC_RS20865	COG0475	glutathione-regulated potassium exporter activity
MSSAC_RS20870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSAC_RS20895	COG1012	belongs to the aldehyde dehydrogenase family
MSSAC_RS20905	COG1215	transferase activity, transferring glycosyl groups
MSSAC_RS20910	COG0640	Transcriptional regulator
MSSAC_RS20915	COG0864	Transcriptional regulator
MSSAC_RS20950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MSSAC_RS21095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MSSAC_RS21125	COG1136	(ABC) transporter
MSSAC_RS21140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSSAC_RS21155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSSAC_RS21160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MSSAC_RS21165	COG1196	nuclear chromosome segregation
MSSAC_RS21180	COG1918	ferrous iron import across plasma membrane
MSSAC_RS21180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSSAC_RS21190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSSAC_RS21205	COG1268	BioY protein
MSSAC_RS21210	COG1122	ATPase activity
MSSAC_RS21215	COG1122	ATPase activity
MSSAC_RS21220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSAC_RS21225	COG0640	Transcriptional regulator
MSSAC_RS21255	COG0303	'Molybdopterin
MSSAC_RS21265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSSAC_RS21270	COG1181	Belongs to the D-alanine--D-alanine ligase family
MSSAC_RS21285	COG1785	Belongs to the alkaline phosphatase family
MSSAC_RS21290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSAC_RS21345	COG4152	abc transporter atp-binding protein
MSSAC_RS21365	COG0784	Response regulator, receiver
MSSAC_RS21370	COG2205	protein histidine kinase activity
MSSAC_RS21370	COG2202	Pas domain
MSSAC_RS21375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSAC_RS21390	COG0523	cobalamin synthesis protein
MSSAC_RS21410	COG5012	cobalamin binding
MSSAC_RS21435	COG0523	cobalamin synthesis protein
MSSAC_RS21445	COG5012	cobalamin binding
MSSAC_RS21455	COG1584	GPR1 FUN34 yaaH family protein
MSSAC_RS21520	COG0012	GTP binding
MSSAC_RS21540	COG1234	tRNA 3'-trailer cleavage
MSSAC_RS21545	COG0396	ATPase activity
MSSAC_RS21550	COG0719	Fe-S assembly protein
MSSAC_RS21550	COG1372	Participates in initiation and elongation during chromosome replication
MSSAC_RS21575	COG2181	nitrate reductase activity
MSSAC_RS21575	COG0247	lactate metabolic process
MSSAC_RS21615	COG0343	queuine tRNA-ribosyltransferase activity
MSSAC_RS21620	COG0109	protoheme IX farnesyltransferase activity
MSSAC_RS21640	COG3830	Belongs to the UPF0237 family
MSSAC_RS21640	COG0560	Phosphoserine phosphatase
MSSAC_RS21660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSSAC_RS21670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSSAC_RS21675	COG1891	lyase activity
MSSAC_RS21710	COG1442	glycosyl transferase family 8
MSSAC_RS21710	COG1216	Glycosyl transferase, family 2
MSSAC_RS21765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MSSAC_RS21770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSSAC_RS21775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSSAC_RS21790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSSAC_RS21830	COG0110	maltose O-acetyltransferase activity
MSSAC_RS21840	COG0673	inositol 2-dehydrogenase activity
MSSAC_RS21855	COG0297	glycogen (starch) synthase activity
MSSAC_RS21860	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS21965	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS21970	COG0662	Cupin 2, conserved barrel domain protein
MSSAC_RS21970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MSSAC_RS21975	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MSSAC_RS21980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MSSAC_RS22010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSSAC_RS22080	COG4467	Involved in initiation control of chromosome replication
MSSAC_RS22095	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS22100	COG2843	Capsule synthesis protein
MSSAC_RS22110	COG0110	maltose O-acetyltransferase activity
MSSAC_RS22115	COG0726	polysaccharide deacetylase
MSSAC_RS22120	COG0463	Glycosyl transferase, family 2
MSSAC_RS22185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSSAC_RS22190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSSAC_RS22255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSAC_RS22270	COG2111	Na H antiporter
MSSAC_RS22270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSSAC_RS22275	COG2111	Na H antiporter
MSSAC_RS22280	COG1006	Multisubunit Na H antiporter MnhC subunit
MSSAC_RS22285	COG0651	ATP synthesis coupled electron transport
MSSAC_RS22290	COG1863	multisubunit Na H antiporter MnhE subunit
MSSAC_RS22300	COG1320	monovalent cation:proton antiporter activity
MSSAC_RS22305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSSAC_RS22325	COG2205	protein histidine kinase activity
MSSAC_RS22340	COG5012	cobalamin binding
MSSAC_RS22350	COG0523	cobalamin synthesis protein
MSSAC_RS22355	COG1850	ribulose-bisphosphate carboxylase activity
MSSAC_RS22360	COG0009	L-threonylcarbamoyladenylate synthase
MSSAC_RS22410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSSAC_RS22415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSSAC_RS22420	COG0501	Belongs to the peptidase M48B family
MSSAC_RS22425	COG1715	Restriction endonuclease
MSSAC_RS22430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MSSAC_RS22450	COG0463	Glycosyl transferase, family 2
MSSAC_RS22460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSSAC_RS22475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSAC_RS22480	COG1120	ATPase activity
MSSAC_RS22490	COG2264	protein methyltransferase activity
MSSAC_RS22495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSSAC_RS22500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSSAC_RS22505	COG0154	amidase activity
MSSAC_RS22545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSSAC_RS22550	COG0456	acetyltransferase
MSSAC_RS22560	COG0519	Catalyzes the synthesis of GMP from XMP
MSSAC_RS22560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSSAC_RS22575	COG3328	transposase activity
MSSAC_RS22605	COG0514	ATP-dependent DNA helicase (RecQ)
MSSAC_RS22630	COG0540	Belongs to the ATCase OTCase family
MSSAC_RS22635	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MSSAC_RS22795	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSSAC_RS22800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSSAC_RS22810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSSAC_RS22815	COG0643	Histidine kinase
MSSAC_RS22815	COG2198	Histidine kinase
MSSAC_RS22820	COG2201	protein-glutamate methylesterase activity
MSSAC_RS22825	COG2201	protein-glutamate methylesterase activity
MSSAC_RS22830	COG0784	Response regulator, receiver
MSSAC_RS22835	COG0840	transmembrane signaling receptor activity
MSSAC_RS22845	COG2610	gluconate transmembrane transporter activity
MSSAC_RS22860	COG1121	(ABC) transporter
MSSAC_RS22865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MSSAC_RS22890	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS22895	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSAC_RS22935	COG0018	arginyl-trna synthetase
MSSAC_RS22980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS22985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS22990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS22995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSAC_RS23010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSSAC_RS23030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSSAC_RS23055	COG1260	myo-inositol-1-phosphate synthase
MSSAC_RS23060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSSAC_RS23085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSSAC_RS23090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSSAC_RS23095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MSSAC_RS23115	COG0459	protein refolding
MSSAC_RS23130	COG0076	glutamate decarboxylase activity
MSSAC_RS23135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSSAC_RS23145	COG2205	protein histidine kinase activity
MSSAC_RS23145	COG2202	Pas domain
MSSAC_RS23200	COG2205	protein histidine kinase activity
MSSAC_RS23200	COG2202	Pas domain
MSSAC_RS23295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSAC_RS23300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSAC_RS23405	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS23465	COG0732	type I restriction modification DNA specificity domain
MSSAC_RS23500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSSAC_RS23575	COG0384	phenazine biosynthesis protein PhzF
MSSAC_RS23620	COG0438	transferase activity, transferring glycosyl groups
MSSAC_RS23620	COG1216	Glycosyl transferase, family 2
MSSAC_RS23850	COG1598	PFAM Uncharacterised protein family UPF0150
MSSAC_RS24070	COG5002	protein histidine kinase activity
MSSAC_RS24150	COG3852	Histidine kinase
MSSAC_RS24160	COG3422	double-strand break repair
MSSAC_RS24380	COG3344	reverse transcriptase
MSSAC_RS24395	COG4166	transmembrane transport
MSSAC_RS24595	COG2205	protein histidine kinase activity
MSSAC_RS24730	COG0697	spore germination
MSSAC_RS24825	COG3420	alginic acid biosynthetic process
MSSAC_RS24975	COG2361	Protein of unknown function DUF86
MSSAC_RS25025	COG0443	Heat shock 70 kDa protein