locus-tag	class	description
MSSIH_RS00045	COG2205	protein histidine kinase activity
MSSIH_RS00045	COG2202	Pas domain
MSSIH_RS00080	COG0516	GMP reductase activity
MSSIH_RS00080	COG0517	IMP dehydrogenase activity
MSSIH_RS00085	COG0517	IMP dehydrogenase activity
MSSIH_RS00085	COG0617	tRNA 3'-terminal CCA addition
MSSIH_RS00085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MSSIH_RS00100	COG0517	IMP dehydrogenase activity
MSSIH_RS00115	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MSSIH_RS00120	COG0430	RNA-3'-phosphate cyclase activity
MSSIH_RS00125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSIH_RS00160	COG0277	FAD linked oxidase domain protein
MSSIH_RS00165	COG0247	lactate metabolic process
MSSIH_RS00185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSSIH_RS00190	COG0084	hydrolase, TatD family'
MSSIH_RS00195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSIH_RS00230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSSIH_RS00235	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSSIH_RS00245	COG1120	ATPase activity
MSSIH_RS00250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS00265	COG0747	negative chemotaxis
MSSIH_RS00275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS00280	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS00285	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS00295	COG1605	Chorismate mutase
MSSIH_RS00295	COG0287	Prephenate dehydrogenase
MSSIH_RS00300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSSIH_RS00305	COG0710	3-dehydroquinate dehydratase activity
MSSIH_RS00310	COG1465	3-dehydroquinate synthase
MSSIH_RS00315	COG1830	Aldolase
MSSIH_RS00320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSSIH_RS00320	COG0519	Catalyzes the synthesis of GMP from XMP
MSSIH_RS00325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSSIH_RS00360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSSIH_RS00390	COG0322	excinuclease ABC activity
MSSIH_RS00395	COG0423	glycine-tRNA ligase activity
MSSIH_RS00425	COG1584	GPR1 FUN34 yaaH family protein
MSSIH_RS00430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSSIH_RS00435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MSSIH_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
MSSIH_RS00480	COG0688	phosphatidylethanolamine metabolic process
MSSIH_RS00485	COG1183	phosphatidylcholine synthase activity
MSSIH_RS00495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSSIH_RS00500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSSIH_RS00560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSSIH_RS00570	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSSIH_RS00575	COG0071	Belongs to the small heat shock protein (HSP20) family
MSSIH_RS00585	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MSSIH_RS00585	COG0778	Nitroreductase
MSSIH_RS00590	COG2131	deaminase
MSSIH_RS00605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSSIH_RS00610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSSIH_RS00630	COG0531	amino acid
MSSIH_RS00640	COG5012	cobalamin binding
MSSIH_RS00645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSIH_RS00695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSSIH_RS00705	COG1342	Belongs to the UPF0251 family
MSSIH_RS00720	COG0731	radical SAM domain protein
MSSIH_RS00720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSSIH_RS00725	COG1528	Iron-storage protein
MSSIH_RS00730	COG0589	response to stress
MSSIH_RS00790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSIH_RS00820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS00835	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSSIH_RS00845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSSIH_RS00850	COG4279	zinc finger
MSSIH_RS00880	COG1993	acr, cog1993
MSSIH_RS00885	COG0473	3-isopropylmalate dehydrogenase activity
MSSIH_RS00890	COG0066	3-isopropylmalate dehydratase activity
MSSIH_RS00895	COG3852	Histidine kinase
MSSIH_RS00915	COG0101	tRNA pseudouridine synthase activity
MSSIH_RS00925	COG3377	Domain of unknown function (DUF1805)
MSSIH_RS00965	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSSIH_RS00970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSSIH_RS00975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSSIH_RS00980	COG0131	Imidazoleglycerol-phosphate dehydratase
MSSIH_RS00985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSSIH_RS01055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSSIH_RS01065	COG1214	PFAM Peptidase M22, glycoprotease
MSSIH_RS01065	COG0456	acetyltransferase
MSSIH_RS01070	COG1606	tRNA processing
MSSIH_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSSIH_RS01080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSSIH_RS01105	COG0372	Belongs to the citrate synthase family
MSSIH_RS01110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MSSIH_RS01130	COG0714	Associated with various cellular activities
MSSIH_RS01135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSSIH_RS01160	COG0235	Class ii aldolase
MSSIH_RS01165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSSIH_RS01185	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSSIH_RS01235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MSSIH_RS01240	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSSIH_RS01245	COG4208	sulfate ABC transporter
MSSIH_RS01250	COG3842	ATPase activity
MSSIH_RS01325	COG2226	methyltransferase
MSSIH_RS01335	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS01345	COG0601	transmembrane transport
MSSIH_RS01350	COG0747	negative chemotaxis
MSSIH_RS01355	COG2226	methyltransferase
MSSIH_RS01370	COG1229	Formylmethanofuran dehydrogenase subunit A
MSSIH_RS01390	COG2968	Membrane
MSSIH_RS01415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSSIH_RS01420	COG0561	phosphatase activity
MSSIH_RS01440	COG3842	ATPase activity
MSSIH_RS01455	COG2249	NAD(P)H dehydrogenase (quinone) activity
MSSIH_RS01480	COG1733	regulation of RNA biosynthetic process
MSSIH_RS01485	COG0534	Mate efflux family protein
MSSIH_RS01550	COG0428	transporter
MSSIH_RS01565	COG1122	ATPase activity
MSSIH_RS01575	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSSIH_RS01580	COG0310	cobalt ion transport
MSSIH_RS01635	COG1429	ligase activity, forming nitrogen-metal bonds
MSSIH_RS01655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSSIH_RS01660	COG1136	(ABC) transporter
MSSIH_RS01675	COG0577	efflux transmembrane transporter activity
MSSIH_RS01675	COG1136	(ABC) transporter
MSSIH_RS01685	COG0528	UMP kinase activity
MSSIH_RS01735	COG3548	integral membrane protein
MSSIH_RS01740	COG1309	transcriptional regulator
MSSIH_RS01750	COG1064	alcohol dehydrogenase
MSSIH_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
MSSIH_RS01815	COG1063	alcohol dehydrogenase
MSSIH_RS01820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSSIH_RS01845	COG1691	(AIR) carboxylase
MSSIH_RS01850	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MSSIH_RS01880	COG0523	cobalamin synthesis protein
MSSIH_RS01900	COG1830	Aldolase
MSSIH_RS01920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSSIH_RS01925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSSIH_RS01935	COG0577	efflux transmembrane transporter activity
MSSIH_RS01960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MSSIH_RS01980	COG5012	cobalamin binding
MSSIH_RS02065	COG3384	dioxygenase
MSSIH_RS02080	COG2205	protein histidine kinase activity
MSSIH_RS02080	COG2202	Pas domain
MSSIH_RS02090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MSSIH_RS02095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MSSIH_RS02095	COG0456	acetyltransferase
MSSIH_RS02180	COG4467	Involved in initiation control of chromosome replication
MSSIH_RS02215	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MSSIH_RS02220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSSIH_RS02225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSSIH_RS02245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MSSIH_RS02255	COG5012	cobalamin binding
MSSIH_RS02265	COG5012	cobalamin binding
MSSIH_RS02305	COG3613	nucleoside 2-deoxyribosyltransferase
MSSIH_RS02310	COG0826	peptidase U32
MSSIH_RS02325	COG0107	imidazoleglycerol-phosphate synthase activity
MSSIH_RS02335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSSIH_RS02355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSSIH_RS02355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSSIH_RS02360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MSSIH_RS02365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSSIH_RS02375	COG3920	Histidine kinase
MSSIH_RS02480	COG0535	radical SAM domain protein
MSSIH_RS02490	COG1522	sequence-specific DNA binding
MSSIH_RS02495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSSIH_RS02495	COG1648	precorrin-2 dehydrogenase activity
MSSIH_RS02500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSSIH_RS02505	COG0113	porphobilinogen synthase activity
MSSIH_RS02515	COG0181	hydroxymethylbilane synthase activity
MSSIH_RS02520	COG0167	dihydroorotate dehydrogenase activity
MSSIH_RS02525	COG0543	2 iron, 2 sulfur cluster binding
MSSIH_RS02530	COG0179	Fumarylacetoacetate (FAA) hydrolase
MSSIH_RS02560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MSSIH_RS02575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSSIH_RS02580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSSIH_RS02600	COG0052	Belongs to the universal ribosomal protein uS2 family
MSSIH_RS02605	COG1355	regulation of microtubule-based process
MSSIH_RS02610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MSSIH_RS02615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSSIH_RS02620	COG1304	FMN binding
MSSIH_RS02635	COG0574	Belongs to the PEP-utilizing enzyme family
MSSIH_RS02635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSSIH_RS02670	COG2084	Dehydrogenase
MSSIH_RS02735	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSIH_RS02745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSSIH_RS02750	COG0459	protein refolding
MSSIH_RS02790	COG1592	Rubrerythrin
MSSIH_RS02820	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSIH_RS02855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MSSIH_RS02880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MSSIH_RS02885	COG1477	protein flavinylation
MSSIH_RS02895	COG4656	Part of a membrane complex involved in electron transport
MSSIH_RS02910	COG4660	Part of a membrane complex involved in electron transport
MSSIH_RS02915	COG4657	Part of a membrane complex involved in electron transport
MSSIH_RS02920	COG2878	Part of a membrane complex involved in electron transport
MSSIH_RS02920	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSIH_RS02935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MSSIH_RS02945	COG2255	four-way junction helicase activity
MSSIH_RS02970	COG5016	pyruvate
MSSIH_RS02970	COG0511	ligase activity, forming carbon-carbon bonds
MSSIH_RS02975	COG0439	Biotin carboxylase
MSSIH_RS02980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSSIH_RS02980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSSIH_RS03025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSIH_RS03040	COG2181	nitrate reductase activity
MSSIH_RS03040	COG0247	lactate metabolic process
MSSIH_RS03055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MSSIH_RS03060	COG2081	HI0933 family
MSSIH_RS03085	COG1144	Oxidoreductase
MSSIH_RS03090	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS03095	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS03100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS03110	COG0747	negative chemotaxis
MSSIH_RS03165	COG0163	prenyltransferase activity
MSSIH_RS03175	COG1078	dGTPase activity
MSSIH_RS03180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MSSIH_RS03190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSSIH_RS03205	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSIH_RS03220	COG2814	Major facilitator Superfamily
MSSIH_RS03230	COG1373	ATPase (AAA superfamily
MSSIH_RS03255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSSIH_RS03255	COG1796	DNA polymerase
MSSIH_RS03260	COG1793	dna ligase
MSSIH_RS03300	COG1846	Transcriptional regulator
MSSIH_RS03315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSIH_RS03325	COG0424	maF-like protein
MSSIH_RS03330	COG0215	cysteine-tRNA ligase activity
MSSIH_RS03345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSSIH_RS03365	COG3920	Histidine kinase
MSSIH_RS03370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSSIH_RS03375	COG2205	protein histidine kinase activity
MSSIH_RS03375	COG2202	Pas domain
MSSIH_RS03390	COG1201	RNA secondary structure unwinding
MSSIH_RS03440	COG2226	methyltransferase
MSSIH_RS03460	COG1247	-acetyltransferase
MSSIH_RS03490	COG0697	spore germination
MSSIH_RS03510	COG1739	Uncharacterized protein family UPF0029
MSSIH_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSSIH_RS03525	COG0765	amino acid transport
MSSIH_RS03540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MSSIH_RS03545	COG2235	arginine
MSSIH_RS03575	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS03620	COG0822	iron-sulfur transferase activity
MSSIH_RS03625	COG1104	cysteine desulfurase activity
MSSIH_RS03630	COG2210	Belongs to the sulfur carrier protein TusA family
MSSIH_RS03635	COG0425	Belongs to the sulfur carrier protein TusA family
MSSIH_RS03640	COG0537	adenosine 5'-monophosphoramidase activity
MSSIH_RS03660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSSIH_RS03680	COG0039	L-malate dehydrogenase activity
MSSIH_RS03740	COG1229	Formylmethanofuran dehydrogenase subunit A
MSSIH_RS03745	COG3383	formate dehydrogenase (NAD+) activity
MSSIH_RS03750	COG0243	molybdopterin cofactor binding
MSSIH_RS03765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MSSIH_RS03770	COG0601	transmembrane transport
MSSIH_RS03785	COG1131	(ABC) transporter
MSSIH_RS03835	COG0456	acetyltransferase
MSSIH_RS03835	COG1846	Transcriptional regulator
MSSIH_RS03845	COG0523	cobalamin synthesis protein
MSSIH_RS03860	COG5012	cobalamin binding
MSSIH_RS03905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSIH_RS03910	COG1122	ATPase activity
MSSIH_RS03950	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS03955	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS03960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS03980	COG0747	negative chemotaxis
MSSIH_RS03990	COG0417	DNA replication proofreading
MSSIH_RS03995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSSIH_RS04000	COG0573	inorganic phosphate transmembrane transporter activity
MSSIH_RS04005	COG0581	inorganic phosphate transmembrane transporter activity
MSSIH_RS04010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSSIH_RS04020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MSSIH_RS04025	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSIH_RS04065	COG0316	Belongs to the HesB IscA family
MSSIH_RS04080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSSIH_RS04110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSSIH_RS04140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSSIH_RS04170	COG1522	sequence-specific DNA binding
MSSIH_RS04175	COG0436	Aminotransferase
MSSIH_RS04205	COG1372	Participates in initiation and elongation during chromosome replication
MSSIH_RS04205	COG0719	Fe-S assembly protein
MSSIH_RS04210	COG0396	ATPase activity
MSSIH_RS04215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSSIH_RS04220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MSSIH_RS04230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSSIH_RS04235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSSIH_RS04240	COG0124	histidyl-tRNA synthetase
MSSIH_RS04270	COG1120	ATPase activity
MSSIH_RS04275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS04300	COG0157	Belongs to the NadC ModD family
MSSIH_RS04310	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MSSIH_RS04315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSSIH_RS04325	COG0109	protoheme IX farnesyltransferase activity
MSSIH_RS04330	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MSSIH_RS04335	COG1458	PINc domain ribonuclease
MSSIH_RS04345	COG3118	belongs to the thioredoxin family
MSSIH_RS04350	COG2274	protein secretion by the type I secretion system
MSSIH_RS04350	COG3271	cysteine-type peptidase activity
MSSIH_RS04355	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MSSIH_RS04360	COG0284	orotidine-5'-phosphate decarboxylase activity
MSSIH_RS04390	COG0659	secondary active sulfate transmembrane transporter activity
MSSIH_RS04475	COG1598	PFAM Uncharacterised protein family UPF0150
MSSIH_RS04520	COG1047	Peptidyl-prolyl cis-trans
MSSIH_RS04565	COG1115	amino acid carrier protein
MSSIH_RS04580	COG1136	(ABC) transporter
MSSIH_RS04600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSIH_RS04610	COG3259	Nickel-dependent hydrogenase
MSSIH_RS04625	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MSSIH_RS04630	COG0735	belongs to the Fur family
MSSIH_RS04640	COG3875	lactate racemase activity
MSSIH_RS04645	COG3875	lactate racemase activity
MSSIH_RS04660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MSSIH_RS04720	COG2361	Protein of unknown function DUF86
MSSIH_RS04765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSIH_RS04775	COG0587	DNA-directed DNA polymerase activity
MSSIH_RS04830	COG1418	mRNA catabolic process
MSSIH_RS04855	COG0402	S-adenosylhomocysteine deaminase activity
MSSIH_RS04860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSSIH_RS04870	COG3852	Histidine kinase
MSSIH_RS04880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSSIH_RS04890	COG4251	negative regulation of phosphorylation
MSSIH_RS04895	COG0784	Response regulator, receiver
MSSIH_RS04900	COG0784	Response regulator, receiver
MSSIH_RS04925	COG0085	RNA polymerase activity
MSSIH_RS04930	COG0085	RNA polymerase activity
MSSIH_RS04935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSSIH_RS04940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSSIH_RS04960	COG0049	tRNA binding
MSSIH_RS04965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MSSIH_RS04970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSSIH_RS04975	COG0051	transcription antitermination factor activity, RNA binding
MSSIH_RS05000	COG0747	negative chemotaxis
MSSIH_RS05010	COG2226	methyltransferase
MSSIH_RS05015	COG0601	transmembrane transport
MSSIH_RS05020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS05025	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS05040	COG3585	molybdate ion transport
MSSIH_RS05050	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSSIH_RS05055	COG4149	molybdate abc transporter
MSSIH_RS05060	COG3842	ATPase activity
MSSIH_RS05085	COG0561	phosphatase activity
MSSIH_RS05095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSSIH_RS05105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MSSIH_RS05115	COG2155	Conserved Protein
MSSIH_RS05120	COG1122	ATPase activity
MSSIH_RS05130	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MSSIH_RS05135	COG0310	cobalt ion transport
MSSIH_RS05200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSSIH_RS05205	COG0517	IMP dehydrogenase activity
MSSIH_RS05210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSSIH_RS05215	COG3613	nucleoside 2-deoxyribosyltransferase
MSSIH_RS05220	COG0456	acetyltransferase
MSSIH_RS05245	COG0577	efflux transmembrane transporter activity
MSSIH_RS05245	COG1136	(ABC) transporter
MSSIH_RS05270	COG0071	Belongs to the small heat shock protein (HSP20) family
MSSIH_RS05275	COG2814	Major facilitator Superfamily
MSSIH_RS05280	COG2078	PFAM AMMECR1 domain protein
MSSIH_RS05285	COG0126	phosphoglycerate kinase activity
MSSIH_RS05290	COG1573	uracil-dna glycosylase
MSSIH_RS05355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSSIH_RS05355	COG1042	CoA-binding domain protein
MSSIH_RS05355	COG0045	succinate-CoA ligase (ADP-forming) activity
MSSIH_RS05360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSSIH_RS05365	COG0280	phosphate acetyltransferase
MSSIH_RS05375	COG0038	chloride channel
MSSIH_RS05385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSIH_RS05405	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MSSIH_RS05410	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MSSIH_RS05430	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MSSIH_RS05440	COG0298	carbon dioxide binding
MSSIH_RS05450	COG0375	protein maturation
MSSIH_RS05455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSSIH_RS05460	COG0309	Hydrogenase expression formation protein (HypE)
MSSIH_RS05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSIH_RS05475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSSIH_RS05490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MSSIH_RS05495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSSIH_RS05500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSSIH_RS05505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSSIH_RS05550	COG3118	belongs to the thioredoxin family
MSSIH_RS05580	COG1121	(ABC) transporter
MSSIH_RS05585	COG4581	dead DEAH box helicase
MSSIH_RS05605	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MSSIH_RS05610	COG0351	phosphomethylpyrimidine kinase
MSSIH_RS05625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSSIH_RS05630	COG0432	Pfam Uncharacterised protein family UPF0047
MSSIH_RS05640	COG0534	Mate efflux family protein
MSSIH_RS05650	COG1846	Transcriptional regulator
MSSIH_RS05660	COG1160	GTP binding
MSSIH_RS05670	COG2813	Specifically methylates the guanine in position
MSSIH_RS05675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS05690	COG1120	ATPase activity
MSSIH_RS05695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS05700	COG2226	methyltransferase
MSSIH_RS05705	COG0534	Mate efflux family protein
MSSIH_RS05765	COG0577	efflux transmembrane transporter activity
MSSIH_RS05765	COG1136	(ABC) transporter
MSSIH_RS05775	COG1136	(ABC) transporter
MSSIH_RS05790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSIH_RS05795	COG1733	regulation of RNA biosynthetic process
MSSIH_RS05800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSSIH_RS05870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MSSIH_RS05930	COG0436	Aminotransferase
MSSIH_RS05945	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSSIH_RS05950	COG0826	peptidase U32
MSSIH_RS06000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MSSIH_RS06005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSSIH_RS06010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSSIH_RS06020	COG0530	calcium, potassium:sodium antiporter activity
MSSIH_RS06065	COG1945	arginine decarboxylase activity
MSSIH_RS06090	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSSIH_RS06130	COG1131	(ABC) transporter
MSSIH_RS06185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MSSIH_RS06190	COG0495	leucyl-tRNA aminoacylation
MSSIH_RS06205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MSSIH_RS06220	COG5012	cobalamin binding
MSSIH_RS06255	COG3920	Histidine kinase
MSSIH_RS06285	COG3920	Histidine kinase
MSSIH_RS06320	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS06325	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS06330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS06370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSSIH_RS06375	COG0151	Belongs to the GarS family
MSSIH_RS06380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSSIH_RS06395	COG1138	Cytochrome C-type biogenesis protein
MSSIH_RS06485	COG0470	DNA polymerase III
MSSIH_RS06485	COG1067	ATP-dependent peptidase activity
MSSIH_RS06495	COG0312	modulator of DNA gyrase
MSSIH_RS06510	COG0589	response to stress
MSSIH_RS06515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSIH_RS06520	COG2835	tetraacyldisaccharide 4'-kinase activity
MSSIH_RS06530	COG0504	CTP synthase activity
MSSIH_RS06580	COG1136	(ABC) transporter
MSSIH_RS06590	COG1136	(ABC) transporter
MSSIH_RS06590	COG0577	efflux transmembrane transporter activity
MSSIH_RS06605	COG2205	protein histidine kinase activity
MSSIH_RS06615	COG2205	protein histidine kinase activity
MSSIH_RS06655	COG0058	SHG alpha-glucan phosphorylase activity
MSSIH_RS06680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MSSIH_RS06690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MSSIH_RS06690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSSIH_RS06725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSSIH_RS06735	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSSIH_RS06745	COG2814	Major facilitator Superfamily
MSSIH_RS06805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MSSIH_RS06810	COG0589	response to stress
MSSIH_RS06815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSSIH_RS06855	COG2326	polyphosphate kinase activity
MSSIH_RS06865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSIH_RS06875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MSSIH_RS06900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSIH_RS06925	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSIH_RS06945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MSSIH_RS06955	COG1215	transferase activity, transferring glycosyl groups
MSSIH_RS06970	COG0574	Belongs to the PEP-utilizing enzyme family
MSSIH_RS06970	COG3848	Pyruvate phosphate dikinase
MSSIH_RS07055	COG4717	serine-type aminopeptidase activity
MSSIH_RS07060	COG0420	3'-5' exonuclease activity
MSSIH_RS07090	COG1598	PFAM Uncharacterised protein family UPF0150
MSSIH_RS07165	COG1324	tolerance protein
MSSIH_RS07185	COG0569	domain protein
MSSIH_RS07190	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSSIH_RS07210	COG2153	protein acetylation
MSSIH_RS07220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MSSIH_RS07240	COG0356	it plays a direct role in the translocation of protons across the membrane
MSSIH_RS07250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MSSIH_RS07255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MSSIH_RS07260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MSSIH_RS07270	COG1073	alpha beta
MSSIH_RS07325	COG3063	Type IV pilus biogenesis stability protein PilW
MSSIH_RS07345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MSSIH_RS07355	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSIH_RS07355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSSIH_RS07365	COG1858	cytochrome C peroxidase
MSSIH_RS07375	COG0531	amino acid
MSSIH_RS07380	COG0426	domain, Protein
MSSIH_RS07390	COG0393	Putative heavy-metal-binding
MSSIH_RS07405	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSSIH_RS07420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSSIH_RS07430	COG2032	superoxide dismutase activity
MSSIH_RS07445	COG5012	cobalamin binding
MSSIH_RS07505	COG0306	phosphate transporter
MSSIH_RS07535	COG1132	(ABC) transporter
MSSIH_RS07560	COG0352	thiamine-phosphate diphosphorylase activity
MSSIH_RS07565	COG1045	serine acetyltransferase
MSSIH_RS07580	COG0017	Asparaginyl-tRNA synthetase
MSSIH_RS07585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSSIH_RS07600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSIH_RS07615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS07680	COG1309	transcriptional regulator
MSSIH_RS07685	COG2816	NAD+ diphosphatase activity
MSSIH_RS07690	COG2890	protein-(glutamine-N5) methyltransferase activity
MSSIH_RS07695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSSIH_RS07730	COG3174	membrane
MSSIH_RS07745	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MSSIH_RS07775	COG0589	response to stress
MSSIH_RS07790	COG0301	tRNA thio-modification
MSSIH_RS07795	COG0745	RESPONSE REGULATOR receiver
MSSIH_RS07855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MSSIH_RS07860	COG0443	Heat shock 70 kDa protein
MSSIH_RS07865	COG0484	heat shock protein binding
MSSIH_RS07880	COG0569	domain protein
MSSIH_RS07910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSSIH_RS07920	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MSSIH_RS07940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSIH_RS07945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSIH_RS07950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSIH_RS07950	COG0649	NAD binding
MSSIH_RS07955	COG0649	NAD binding
MSSIH_RS07965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSIH_RS07980	COG0713	ATP synthesis coupled electron transport
MSSIH_RS07990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSSIH_RS07995	COG1007	ATP synthesis coupled electron transport
MSSIH_RS08070	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MSSIH_RS08090	COG4467	Involved in initiation control of chromosome replication
MSSIH_RS08140	COG0318	PFAM AMP-dependent synthetase and ligase
MSSIH_RS08155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSIH_RS08160	COG1122	ATPase activity
MSSIH_RS08205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MSSIH_RS08255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MSSIH_RS08265	COG0864	Transcriptional regulator
MSSIH_RS08285	COG0140	phosphoribosyl-ATP diphosphatase activity
MSSIH_RS08285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSSIH_RS08295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSSIH_RS08310	COG0436	Aminotransferase
MSSIH_RS08315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSSIH_RS08330	COG1160	GTP binding
MSSIH_RS08350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSSIH_RS08360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSSIH_RS08385	COG0492	ferredoxin-NADP+ reductase activity
MSSIH_RS08395	COG0745	RESPONSE REGULATOR receiver
MSSIH_RS08405	COG0546	phosphoglycolate phosphatase activity
MSSIH_RS08440	COG0148	phosphopyruvate hydratase activity
MSSIH_RS08455	COG1136	(ABC) transporter
MSSIH_RS08485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MSSIH_RS08495	COG0134	indole-3-glycerol-phosphate synthase activity
MSSIH_RS08500	COG0133	tryptophan synthase activity
MSSIH_RS08505	COG0159	tryptophan synthase activity
MSSIH_RS08510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSSIH_RS08515	COG0135	phosphoribosylanthranilate isomerase activity
MSSIH_RS08525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSSIH_RS08525	COG0512	Glutamine amidotransferase of anthranilate synthase
MSSIH_RS08565	COG5012	cobalamin binding
MSSIH_RS08595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSIH_RS08605	COG1301	dicarboxylic acid transport
MSSIH_RS08645	COG1051	belongs to the nudix hydrolase family
MSSIH_RS08670	COG1045	serine acetyltransferase
MSSIH_RS08710	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MSSIH_RS08750	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSIH_RS08770	COG0501	Belongs to the peptidase M48B family
MSSIH_RS08780	COG1131	(ABC) transporter
MSSIH_RS08875	COG0733	neurotransmitter:sodium symporter activity
MSSIH_RS08905	COG0105	UTP biosynthetic process
MSSIH_RS08910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSSIH_RS09025	COG0534	Mate efflux family protein
MSSIH_RS09060	COG0667	Aldo Keto reductase
MSSIH_RS09080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS09100	COG0708	Exodeoxyribonuclease III
MSSIH_RS09160	COG0187	DNA topoisomerase II activity
MSSIH_RS09165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MSSIH_RS09180	COG1373	ATPase (AAA superfamily
MSSIH_RS09205	COG0668	transmembrane transport
MSSIH_RS09230	COG2239	Acts as a magnesium transporter
MSSIH_RS09235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSSIH_RS09235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MSSIH_RS09240	COG0436	Aminotransferase
MSSIH_RS09245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSSIH_RS09255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MSSIH_RS09265	COG2226	methyltransferase
MSSIH_RS09320	COG2003	Belongs to the UPF0758 family
MSSIH_RS09325	COG0314	molybdopterin synthase activity
MSSIH_RS09330	COG0746	molybdenum cofactor guanylyltransferase activity
MSSIH_RS09355	COG0037	tRNA processing
MSSIH_RS09400	COG0367	asparagine synthase
MSSIH_RS09420	COG0047	phosphoribosylformylglycinamidine synthase activity
MSSIH_RS09450	COG0028	Belongs to the TPP enzyme family
MSSIH_RS09480	COG0076	glutamate decarboxylase activity
MSSIH_RS09500	COG2226	methyltransferase
MSSIH_RS09610	COG3344	reverse transcriptase
MSSIH_RS09645	COG2205	protein histidine kinase activity
MSSIH_RS09660	COG0671	phosphoesterase, PA-phosphatase related
MSSIH_RS09670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS09675	COG3920	Histidine kinase
MSSIH_RS09685	COG0534	Mate efflux family protein
MSSIH_RS09700	COG0531	amino acid
MSSIH_RS09715	COG1295	ribonuclease BN
MSSIH_RS09735	COG1136	(ABC) transporter
MSSIH_RS09745	COG1136	(ABC) transporter
MSSIH_RS09745	COG0577	efflux transmembrane transporter activity
MSSIH_RS09755	COG3431	PFAM Phosphate-starvation-inducible E
MSSIH_RS09770	COG3920	Histidine kinase
MSSIH_RS09820	COG1260	myo-inositol-1-phosphate synthase
MSSIH_RS09855	COG0601	transmembrane transport
MSSIH_RS09865	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS09890	COG0583	DNA-binding transcription factor activity
MSSIH_RS09910	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MSSIH_RS09965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSSIH_RS09995	COG1131	(ABC) transporter
MSSIH_RS10005	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MSSIH_RS10080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSSIH_RS10200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MSSIH_RS10220	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MSSIH_RS10225	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MSSIH_RS10235	COG0671	phosphoesterase, PA-phosphatase related
MSSIH_RS10245	COG0412	Dienelactone hydrolase
MSSIH_RS10250	COG1988	membrane-bound metal-dependent
MSSIH_RS10300	COG1846	Transcriptional regulator
MSSIH_RS10310	COG0628	permease
MSSIH_RS10315	COG1131	(ABC) transporter
MSSIH_RS10325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSSIH_RS10370	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSSIH_RS10380	COG0590	tRNA wobble adenosine to inosine editing
MSSIH_RS10385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSSIH_RS10385	COG0574	Belongs to the PEP-utilizing enzyme family
MSSIH_RS10400	COG2095	MarC family integral membrane protein
MSSIH_RS10485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSSIH_RS10510	COG5012	cobalamin binding
MSSIH_RS10535	COG3920	Histidine kinase
MSSIH_RS10540	COG0745	RESPONSE REGULATOR receiver
MSSIH_RS10545	COG0745	RESPONSE REGULATOR receiver
MSSIH_RS10550	COG2326	polyphosphate kinase activity
MSSIH_RS10590	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS10595	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MSSIH_RS10665	COG0358	DNA primase activity
MSSIH_RS10685	COG4974	Belongs to the 'phage' integrase family
MSSIH_RS10750	COG0281	malic enzyme
MSSIH_RS10760	COG2226	methyltransferase
MSSIH_RS10785	COG2172	sigma factor antagonist activity
MSSIH_RS10850	COG2814	Major facilitator Superfamily
MSSIH_RS10870	COG1836	PFAM Integral membrane protein DUF92
MSSIH_RS10875	COG2221	Nitrite and sulphite reductase 4Fe-4S
MSSIH_RS10890	COG0668	transmembrane transport
MSSIH_RS10965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSSIH_RS10975	COG4555	ABC transporter
MSSIH_RS10980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSSIH_RS11030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSSIH_RS11045	COG2226	methyltransferase
MSSIH_RS11055	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSSIH_RS11070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSSIH_RS11080	COG0588	phosphoglycerate mutase activity
MSSIH_RS11090	COG2151	metal-sulfur cluster biosynthetic enzyme
MSSIH_RS11150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MSSIH_RS11180	COG0667	Aldo Keto reductase
MSSIH_RS11185	COG2205	protein histidine kinase activity
MSSIH_RS11260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MSSIH_RS11330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSIH_RS11430	COG3291	Pkd domain containing protein
MSSIH_RS11530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSIH_RS11535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSSIH_RS11545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSSIH_RS11550	COG3920	Histidine kinase
MSSIH_RS11575	COG1254	Belongs to the acylphosphatase family
MSSIH_RS11580	COG2205	protein histidine kinase activity
MSSIH_RS11600	COG0129	dihydroxy-acid dehydratase activity
MSSIH_RS11625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSIH_RS11645	COG2871	sodium ion transport
MSSIH_RS11685	COG0628	permease
MSSIH_RS11720	COG3264	Mechanosensitive ion channel
MSSIH_RS11720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MSSIH_RS11735	COG0628	permease
MSSIH_RS11740	COG0641	radical SAM
MSSIH_RS11745	COG3119	arylsulfatase activity
MSSIH_RS11775	COG2195	Cleaves the N-terminal amino acid of tripeptides
MSSIH_RS11795	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MSSIH_RS11810	COG0732	type I restriction modification DNA specificity domain
MSSIH_RS11840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MSSIH_RS11845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MSSIH_RS11870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSSIH_RS11870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSSIH_RS11880	COG0653	protein targeting
MSSIH_RS11890	COG0426	domain, Protein
MSSIH_RS11920	COG0129	dihydroxy-acid dehydratase activity
MSSIH_RS11935	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MSSIH_RS11960	COG2255	four-way junction helicase activity
MSSIH_RS11975	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSSIH_RS11980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSIH_RS11990	COG2226	methyltransferase
MSSIH_RS11995	COG0601	transmembrane transport
MSSIH_RS12000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS12020	COG2226	methyltransferase
MSSIH_RS12070	COG0456	acetyltransferase
MSSIH_RS12105	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS12120	COG2205	protein histidine kinase activity
MSSIH_RS12145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSSIH_RS12335	COG1136	(ABC) transporter
MSSIH_RS12355	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSIH_RS12360	COG1122	ATPase activity
MSSIH_RS12375	COG0577	efflux transmembrane transporter activity
MSSIH_RS12490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MSSIH_RS12495	COG0322	excinuclease ABC activity
MSSIH_RS12500	COG0556	nucleotide-excision repair
MSSIH_RS12505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSSIH_RS12525	COG0641	radical SAM
MSSIH_RS12530	COG3422	double-strand break repair
MSSIH_RS12540	COG1757	Na H antiporter
MSSIH_RS12550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSSIH_RS12585	COG3852	Histidine kinase
MSSIH_RS12590	COG1028	Short-chain dehydrogenase reductase Sdr
MSSIH_RS12600	COG0165	Argininosuccinate lyase
MSSIH_RS12605	COG0252	asparaginase activity
MSSIH_RS12610	COG4145	pantothenate transmembrane transporter activity
MSSIH_RS12625	COG0822	iron-sulfur transferase activity
MSSIH_RS12630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSSIH_RS12635	COG2873	o-acetylhomoserine
MSSIH_RS12640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MSSIH_RS12645	COG0500	methyltransferase
MSSIH_RS12690	COG1598	PFAM Uncharacterised protein family UPF0150
MSSIH_RS12715	COG0137	argininosuccinate synthase activity
MSSIH_RS12720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSSIH_RS12725	COG0505	Belongs to the CarA family
MSSIH_RS12730	COG4175	Glycine betaine
MSSIH_RS12730	COG0517	IMP dehydrogenase activity
MSSIH_RS12765	COG1215	transferase activity, transferring glycosyl groups
MSSIH_RS12790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSSIH_RS12800	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS12805	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS12880	COG2244	polysaccharide biosynthetic process
MSSIH_RS12885	COG0456	acetyltransferase
MSSIH_RS12900	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MSSIH_RS12980	COG0028	Belongs to the TPP enzyme family
MSSIH_RS13000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSSIH_RS13030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSSIH_RS13045	COG3590	peptidase
MSSIH_RS13050	COG1864	DNA RNA non-specific endonuclease
MSSIH_RS13050	COG3591	Belongs to the peptidase S1B family
MSSIH_RS13070	COG0598	Magnesium transport protein CorA
MSSIH_RS13080	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MSSIH_RS13120	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MSSIH_RS13125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSSIH_RS13130	COG1111	helicase
MSSIH_RS13130	COG1205	dead DEAH box helicase
MSSIH_RS13135	COG1704	LemA family
MSSIH_RS13170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MSSIH_RS13185	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSSIH_RS13195	COG1492	cobalamin metabolic process
MSSIH_RS13235	COG3093	addiction module antidote protein HigA
MSSIH_RS13280	COG0822	iron-sulfur transferase activity
MSSIH_RS13285	COG0189	ligase activity
MSSIH_RS13300	COG0585	pseudouridine synthase activity
MSSIH_RS13305	COG0534	Mate efflux family protein
MSSIH_RS13320	COG4451	ribulose bisphosphate carboxylase, small
MSSIH_RS13320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSSIH_RS13340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MSSIH_RS13350	COG0693	protein deglycase activity
MSSIH_RS13375	COG2205	protein histidine kinase activity
MSSIH_RS13380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSSIH_RS13390	COG1618	nucleotide phosphatase activity, acting on free nucleotides
MSSIH_RS13405	COG3264	Mechanosensitive ion channel
MSSIH_RS13405	COG1511	domain protein
MSSIH_RS13450	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MSSIH_RS13490	COG0688	phosphatidylethanolamine metabolic process
MSSIH_RS13500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MSSIH_RS13505	COG1012	belongs to the aldehyde dehydrogenase family
MSSIH_RS13510	COG2204	response regulator
MSSIH_RS13515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSSIH_RS13530	COG0589	response to stress
MSSIH_RS13540	COG1233	COG1233 Phytoene dehydrogenase and related
MSSIH_RS13680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSSIH_RS13685	COG1061	Type III restriction enzyme res subunit
MSSIH_RS13690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MSSIH_RS13725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSSIH_RS13870	COG1047	Peptidyl-prolyl cis-trans
MSSIH_RS13875	COG1047	Peptidyl-prolyl cis-trans
MSSIH_RS13880	COG1047	Peptidyl-prolyl cis-trans
MSSIH_RS13920	COG0714	Associated with various cellular activities
MSSIH_RS13930	COG0077	Prephenate dehydratase
MSSIH_RS13930	COG1605	Chorismate mutase
MSSIH_RS13940	COG0384	phenazine biosynthesis protein PhzF
MSSIH_RS13965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSSIH_RS14020	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSSIH_RS14025	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSIH_RS14025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MSSIH_RS14045	COG0840	transmembrane signaling receptor activity
MSSIH_RS14050	COG0835	chemotaxis
MSSIH_RS14060	COG2201	protein-glutamate methylesterase activity
MSSIH_RS14065	COG2201	protein-glutamate methylesterase activity
MSSIH_RS14070	COG2198	Histidine kinase
MSSIH_RS14070	COG0643	Histidine kinase
MSSIH_RS14075	COG1776	CheC inhibitor of MCP methylation
MSSIH_RS14080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSSIH_RS14145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS14155	COG0747	negative chemotaxis
MSSIH_RS14160	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS14165	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS14215	COG0535	radical SAM domain protein
MSSIH_RS14235	COG1234	tRNA 3'-trailer cleavage
MSSIH_RS14245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSIH_RS14270	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSIH_RS14295	COG2608	mercury ion transmembrane transporter activity
MSSIH_RS14305	COG1733	regulation of RNA biosynthetic process
MSSIH_RS14315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSSIH_RS14325	COG2217	Heavy metal translocating P-type atpase
MSSIH_RS14335	COG4895	conserved protein (DUF2196)
MSSIH_RS14360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS14365	COG2076	Multidrug Resistance protein
MSSIH_RS14395	COG0028	Belongs to the TPP enzyme family
MSSIH_RS14400	COG1012	belongs to the aldehyde dehydrogenase family
MSSIH_RS14415	COG0730	response to heat
MSSIH_RS14415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSSIH_RS14420	COG4591	ABC-type transport system involved in lipoprotein release permease component
MSSIH_RS14430	COG0747	negative chemotaxis
MSSIH_RS14435	COG0601	transmembrane transport
MSSIH_RS14440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS14450	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS14470	COG1321	iron dependent repressor
MSSIH_RS14505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSSIH_RS14525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSIH_RS14530	COG1132	(ABC) transporter
MSSIH_RS14535	COG1132	(ABC) transporter
MSSIH_RS14535	COG2375	cellular response to nickel ion
MSSIH_RS14550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSSIH_RS14550	COG1918	ferrous iron import across plasma membrane
MSSIH_RS14575	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MSSIH_RS14580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSSIH_RS14585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSSIH_RS14590	COG0805	protein transport
MSSIH_RS14595	COG0805	protein transport
MSSIH_RS14600	COG0697	spore germination
MSSIH_RS14625	COG1945	arginine decarboxylase activity
MSSIH_RS14650	COG1451	nucleotide metabolic process
MSSIH_RS14695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSSIH_RS14700	COG1793	dna ligase
MSSIH_RS14705	COG0460	homoserine dehydrogenase
MSSIH_RS14770	COG0563	adenylate kinase activity
MSSIH_RS14775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MSSIH_RS14785	COG1131	(ABC) transporter
MSSIH_RS14795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSSIH_RS14800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSSIH_RS14830	COG0577	efflux transmembrane transporter activity
MSSIH_RS14830	COG1136	(ABC) transporter
MSSIH_RS14840	COG1136	(ABC) transporter
MSSIH_RS14845	COG0534	Mate efflux family protein
MSSIH_RS14885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MSSIH_RS14885	COG0392	lysyltransferase activity
MSSIH_RS14910	COG0826	peptidase U32
MSSIH_RS14915	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
MSSIH_RS14950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MSSIH_RS14955	COG3830	Belongs to the UPF0237 family
MSSIH_RS14960	COG2848	UPF0210 protein
MSSIH_RS14975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSSIH_RS14995	COG0714	Associated with various cellular activities
MSSIH_RS15035	COG0662	Cupin 2, conserved barrel domain protein
MSSIH_RS15040	COG1120	ATPase activity
MSSIH_RS15045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS15095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MSSIH_RS15105	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSSIH_RS15125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSSIH_RS15130	COG0587	DNA-directed DNA polymerase activity
MSSIH_RS15160	COG2202	Pas domain
MSSIH_RS15160	COG2205	protein histidine kinase activity
MSSIH_RS15175	COG1494	fructose-1,6-bisphosphatase
MSSIH_RS15180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSSIH_RS15195	COG1592	Rubrerythrin
MSSIH_RS15210	COG0420	3'-5' exonuclease activity
MSSIH_RS15215	COG1196	nuclear chromosome segregation
MSSIH_RS15255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MSSIH_RS15260	COG0315	cyclic pyranopterin monophosphate synthase activity
MSSIH_RS15270	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSSIH_RS15270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSSIH_RS15290	COG0463	Glycosyl transferase, family 2
MSSIH_RS15295	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS15300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSSIH_RS15340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MSSIH_RS15345	COG1091	dTDP-4-dehydrorhamnose reductase activity
MSSIH_RS15365	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS15370	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS15380	COG0655	NAD(P)H dehydrogenase (quinone) activity
MSSIH_RS15425	COG1120	ATPase activity
MSSIH_RS15430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS15435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSSIH_RS15465	COG0347	Belongs to the P(II) protein family
MSSIH_RS15470	COG0347	Belongs to the P(II) protein family
MSSIH_RS15485	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MSSIH_RS15490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MSSIH_RS15510	COG0066	3-isopropylmalate dehydratase activity
MSSIH_RS15520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSIH_RS15525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSIH_RS15540	COG1120	ATPase activity
MSSIH_RS15545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS15645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSSIH_RS15655	COG0563	adenylate kinase activity
MSSIH_RS15675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSSIH_RS15700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSSIH_RS15710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MSSIH_RS15725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSSIH_RS15740	COG0255	Belongs to the universal ribosomal protein uL29 family
MSSIH_RS15745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSSIH_RS15750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MSSIH_RS15755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSSIH_RS15765	COG0089	rRNA binding
MSSIH_RS15770	COG0088	Forms part of the polypeptide exit tunnel
MSSIH_RS15775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSSIH_RS15805	COG0501	Belongs to the peptidase M48B family
MSSIH_RS15825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MSSIH_RS15875	COG1215	transferase activity, transferring glycosyl groups
MSSIH_RS15925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MSSIH_RS15975	COG1342	Belongs to the UPF0251 family
MSSIH_RS16020	COG1294	oxidase, subunit
MSSIH_RS16025	COG1271	oxidase subunit
MSSIH_RS16030	COG0735	belongs to the Fur family
MSSIH_RS16040	COG1902	pentaerythritol trinitrate reductase activity
MSSIH_RS16055	COG2226	methyltransferase
MSSIH_RS16130	COG1408	metallophosphoesterase
MSSIH_RS16135	COG0557	exoribonuclease II activity
MSSIH_RS16140	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MSSIH_RS16175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MSSIH_RS16180	COG1518	maintenance of DNA repeat elements
MSSIH_RS16255	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS16275	COG0371	Dehydrogenase
MSSIH_RS16305	COG1185	polyribonucleotide nucleotidyltransferase activity
MSSIH_RS16405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSSIH_RS16410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSSIH_RS16430	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MSSIH_RS16455	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSSIH_RS16460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MSSIH_RS16470	COG0318	PFAM AMP-dependent synthetase and ligase
MSSIH_RS16530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSSIH_RS16535	COG1331	Highly conserved protein containing a thioredoxin domain
MSSIH_RS16560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MSSIH_RS16565	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MSSIH_RS16570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSSIH_RS16600	COG2033	superoxide reductase activity
MSSIH_RS16625	COG0426	domain, Protein
MSSIH_RS16630	COG3527	Alpha-acetolactate decarboxylase
MSSIH_RS16640	COG0473	3-isopropylmalate dehydrogenase activity
MSSIH_RS16655	COG0066	3-isopropylmalate dehydratase activity
MSSIH_RS16680	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS16685	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS16730	COG2226	methyltransferase
MSSIH_RS16755	COG0493	'glutamate synthase
MSSIH_RS16770	COG0778	Nitroreductase
MSSIH_RS16775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSSIH_RS16780	COG0440	acetolactate synthase activity
MSSIH_RS16785	COG0028	Belongs to the TPP enzyme family
MSSIH_RS16790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSIH_RS16800	COG1363	Peptidase, m42
MSSIH_RS16815	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MSSIH_RS16880	COG1215	transferase activity, transferring glycosyl groups
MSSIH_RS16905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MSSIH_RS16910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSSIH_RS16915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MSSIH_RS16920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSSIH_RS16935	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSSIH_RS16940	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MSSIH_RS16945	COG2814	Major facilitator Superfamily
MSSIH_RS16970	COG0442	prolyl-tRNA aminoacylation
MSSIH_RS16975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSSIH_RS17025	COG0644	oxidoreductase
MSSIH_RS17030	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MSSIH_RS17040	COG0347	Belongs to the P(II) protein family
MSSIH_RS17065	COG4149	molybdate abc transporter
MSSIH_RS17070	COG3842	ATPase activity
MSSIH_RS17090	COG2226	methyltransferase
MSSIH_RS17095	COG0747	negative chemotaxis
MSSIH_RS17100	COG0601	transmembrane transport
MSSIH_RS17105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS17110	COG0444	Belongs to the ABC transporter superfamily
MSSIH_RS17140	COG2226	methyltransferase
MSSIH_RS17145	COG0347	Belongs to the P(II) protein family
MSSIH_RS17150	COG0004	ammonium transporteR
MSSIH_RS17155	COG0004	ammonium transporteR
MSSIH_RS17195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSSIH_RS17205	COG1120	ATPase activity
MSSIH_RS17210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS17235	COG0701	Predicted permease
MSSIH_RS17255	COG0798	PFAM Bile acid sodium symporter
MSSIH_RS17290	COG0785	Cytochrome C biogenesis protein
MSSIH_RS17320	COG0513	Belongs to the DEAD box helicase family
MSSIH_RS17330	COG1136	(ABC) transporter
MSSIH_RS17340	COG0577	efflux transmembrane transporter activity
MSSIH_RS17345	COG1136	(ABC) transporter
MSSIH_RS17355	COG2205	protein histidine kinase activity
MSSIH_RS17395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MSSIH_RS17415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MSSIH_RS17420	COG4962	Type ii secretion system protein e
MSSIH_RS17435	COG0456	acetyltransferase
MSSIH_RS17440	COG1509	lysine 2,3-aminomutase activity
MSSIH_RS17455	COG1476	TRANSCRIPTIONal
MSSIH_RS17465	COG0010	Belongs to the arginase family
MSSIH_RS17485	COG5549	protein import
MSSIH_RS17485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSSIH_RS17525	COG1122	ATPase activity
MSSIH_RS17530	COG2217	Heavy metal translocating P-type atpase
MSSIH_RS17555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSSIH_RS17570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSSIH_RS17575	COG1584	GPR1 FUN34 yaaH family protein
MSSIH_RS17595	COG0138	bifunctional purine biosynthesis protein purh
MSSIH_RS17600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSSIH_RS17610	COG0310	cobalt ion transport
MSSIH_RS17630	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSIH_RS17635	COG1122	ATPase activity
MSSIH_RS17670	COG4191	Histidine kinase
MSSIH_RS17675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSSIH_RS17750	COG0183	Belongs to the thiolase family
MSSIH_RS17770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSSIH_RS17770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSSIH_RS17775	COG0616	signal peptide processing
MSSIH_RS17780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSSIH_RS17805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSSIH_RS17840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSSIH_RS17845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSIH_RS17850	COG0321	lipoyl(octanoyl) transferase activity
MSSIH_RS17850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSSIH_RS17865	COG2155	Conserved Protein
MSSIH_RS17870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSSIH_RS17885	COG0535	radical SAM domain protein
MSSIH_RS17905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSSIH_RS17910	COG0081	regulation of translation
MSSIH_RS17915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSSIH_RS17930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MSSIH_RS17955	COG0473	3-isopropylmalate dehydrogenase activity
MSSIH_RS17960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSSIH_RS18005	COG0785	Cytochrome C biogenesis protein
MSSIH_RS18015	COG4608	Belongs to the ABC transporter superfamily
MSSIH_RS18025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSSIH_RS18030	COG0601	transmembrane transport
MSSIH_RS18045	COG0747	negative chemotaxis
MSSIH_RS18055	COG0489	protein tyrosine kinase activity
MSSIH_RS18060	COG1342	Belongs to the UPF0251 family
MSSIH_RS18075	COG0489	protein tyrosine kinase activity
MSSIH_RS18100	COG2048	Heterodisulfide reductase, subunit B
MSSIH_RS18105	COG0247	lactate metabolic process
MSSIH_RS18105	COG2181	nitrate reductase activity
MSSIH_RS18125	COG0024	Methionine aminopeptidase
MSSIH_RS18205	COG0067	glutamate synthase
MSSIH_RS18215	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MSSIH_RS18240	COG0347	Belongs to the P(II) protein family
MSSIH_RS18245	COG0004	ammonium transporteR
MSSIH_RS18285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSSIH_RS18295	COG0602	queuosine metabolic process
MSSIH_RS18300	COG0720	synthase
MSSIH_RS18305	COG0535	radical SAM domain protein
MSSIH_RS18305	COG1433	Dinitrogenase iron-molybdenum cofactor
MSSIH_RS18315	COG2144	transferase activity, transferring acyl groups
MSSIH_RS18345	COG4106	trans-aconitate 2-methyltransferase activity
MSSIH_RS18365	COG1229	Formylmethanofuran dehydrogenase subunit A
MSSIH_RS18415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSIH_RS18420	COG5012	cobalamin binding
MSSIH_RS18440	COG1394	ATPase activity, coupled to movement of substances
MSSIH_RS18445	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MSSIH_RS18450	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MSSIH_RS18475	COG1269	ATP hydrolysis coupled proton transport
MSSIH_RS18485	COG0535	radical SAM domain protein
MSSIH_RS18515	COG0671	phosphoesterase, PA-phosphatase related
MSSIH_RS18590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSIH_RS18605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSSIH_RS18650	COG0552	protein localization to endoplasmic reticulum
MSSIH_RS18655	COG1983	PspC domain protein
MSSIH_RS18665	COG3272	Protein of unknown function (DUF1722)
MSSIH_RS18670	COG0450	alkyl hydroperoxide reductase
MSSIH_RS18675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MSSIH_RS18680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSSIH_RS18685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSSIH_RS18700	COG1872	DUF167
MSSIH_RS18705	COG0402	S-adenosylhomocysteine deaminase activity
MSSIH_RS18715	COG0517	IMP dehydrogenase activity
MSSIH_RS18730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSSIH_RS18735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSSIH_RS18740	COG0303	'Molybdopterin
MSSIH_RS18760	COG0475	glutathione-regulated potassium exporter activity
MSSIH_RS18765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSIH_RS18785	COG1012	belongs to the aldehyde dehydrogenase family
MSSIH_RS18795	COG1215	transferase activity, transferring glycosyl groups
MSSIH_RS18805	COG0640	Transcriptional regulator
MSSIH_RS18810	COG0864	Transcriptional regulator
MSSIH_RS18835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MSSIH_RS18960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MSSIH_RS18995	COG1136	(ABC) transporter
MSSIH_RS19010	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSSIH_RS19025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSSIH_RS19030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MSSIH_RS19035	COG1196	nuclear chromosome segregation
MSSIH_RS19060	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSSIH_RS19070	COG1268	BioY protein
MSSIH_RS19075	COG1122	ATPase activity
MSSIH_RS19080	COG1122	ATPase activity
MSSIH_RS19085	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MSSIH_RS19090	COG0640	Transcriptional regulator
MSSIH_RS19120	COG0303	'Molybdopterin
MSSIH_RS19125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSSIH_RS19130	COG1181	Belongs to the D-alanine--D-alanine ligase family
MSSIH_RS19145	COG1785	Belongs to the alkaline phosphatase family
MSSIH_RS19150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSSIH_RS19210	COG4191	Histidine kinase
MSSIH_RS19210	COG0784	Response regulator, receiver
MSSIH_RS19235	COG4152	abc transporter atp-binding protein
MSSIH_RS19250	COG0784	Response regulator, receiver
MSSIH_RS19255	COG2202	Pas domain
MSSIH_RS19255	COG2205	protein histidine kinase activity
MSSIH_RS19260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MSSIH_RS19275	COG0523	cobalamin synthesis protein
MSSIH_RS19285	COG5012	cobalamin binding
MSSIH_RS19305	COG0523	cobalamin synthesis protein
MSSIH_RS19310	COG5012	cobalamin binding
MSSIH_RS19320	COG1584	GPR1 FUN34 yaaH family protein
MSSIH_RS19380	COG0012	GTP binding
MSSIH_RS19400	COG1234	tRNA 3'-trailer cleavage
MSSIH_RS19405	COG0396	ATPase activity
MSSIH_RS19410	COG0719	Fe-S assembly protein
MSSIH_RS19410	COG1372	Participates in initiation and elongation during chromosome replication
MSSIH_RS19430	COG0247	lactate metabolic process
MSSIH_RS19430	COG2181	nitrate reductase activity
MSSIH_RS19480	COG0343	queuine tRNA-ribosyltransferase activity
MSSIH_RS19485	COG0109	protoheme IX farnesyltransferase activity
MSSIH_RS19505	COG0560	Phosphoserine phosphatase
MSSIH_RS19505	COG3830	Belongs to the UPF0237 family
MSSIH_RS19525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSSIH_RS19535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSSIH_RS19540	COG1891	lyase activity
MSSIH_RS19570	COG1216	Glycosyl transferase, family 2
MSSIH_RS19570	COG1442	glycosyl transferase family 8
MSSIH_RS19620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MSSIH_RS19625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSSIH_RS19630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSSIH_RS19645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSSIH_RS19685	COG0110	maltose O-acetyltransferase activity
MSSIH_RS19695	COG0673	inositol 2-dehydrogenase activity
MSSIH_RS19710	COG0297	glycogen (starch) synthase activity
MSSIH_RS19715	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS19760	COG2244	polysaccharide biosynthetic process
MSSIH_RS19780	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS19790	COG0438	transferase activity, transferring glycosyl groups
MSSIH_RS19805	COG0463	Glycosyl transferase, family 2
MSSIH_RS19875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSSIH_RS19880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSSIH_RS19935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSSIH_RS19950	COG2111	Na H antiporter
MSSIH_RS19950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSSIH_RS19955	COG2111	Na H antiporter
MSSIH_RS19960	COG1006	Multisubunit Na H antiporter MnhC subunit
MSSIH_RS19965	COG0651	ATP synthesis coupled electron transport
MSSIH_RS19970	COG1863	multisubunit Na H antiporter MnhE subunit
MSSIH_RS19980	COG1320	monovalent cation:proton antiporter activity
MSSIH_RS19985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MSSIH_RS20000	COG2205	protein histidine kinase activity
MSSIH_RS20020	COG5012	cobalamin binding
MSSIH_RS20030	COG0523	cobalamin synthesis protein
MSSIH_RS20035	COG1850	ribulose-bisphosphate carboxylase activity
MSSIH_RS20040	COG0009	L-threonylcarbamoyladenylate synthase
MSSIH_RS20090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSSIH_RS20095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSSIH_RS20100	COG0501	Belongs to the peptidase M48B family
MSSIH_RS20105	COG1715	Restriction endonuclease
MSSIH_RS20120	COG2226	methyltransferase
MSSIH_RS20135	COG1373	ATPase (AAA superfamily
MSSIH_RS20150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSSIH_RS20165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSSIH_RS20170	COG1120	ATPase activity
MSSIH_RS20180	COG2264	protein methyltransferase activity
MSSIH_RS20190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSSIH_RS20195	COG0154	amidase activity
MSSIH_RS20235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSSIH_RS20240	COG0456	acetyltransferase
MSSIH_RS20250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSSIH_RS20250	COG0519	Catalyzes the synthesis of GMP from XMP
MSSIH_RS20280	COG0514	ATP-dependent DNA helicase (RecQ)
MSSIH_RS20305	COG0540	Belongs to the ATCase OTCase family
MSSIH_RS20310	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MSSIH_RS20465	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSSIH_RS20470	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSSIH_RS20480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSSIH_RS20485	COG2198	Histidine kinase
MSSIH_RS20485	COG0643	Histidine kinase
MSSIH_RS20490	COG2201	protein-glutamate methylesterase activity
MSSIH_RS20495	COG2201	protein-glutamate methylesterase activity
MSSIH_RS20500	COG0784	Response regulator, receiver
MSSIH_RS20505	COG0840	transmembrane signaling receptor activity
MSSIH_RS20515	COG2610	gluconate transmembrane transporter activity
MSSIH_RS20530	COG1121	(ABC) transporter
MSSIH_RS20535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MSSIH_RS20555	COG1013	pyruvate-flavodoxin oxidoreductase activity
MSSIH_RS20560	COG0674	pyruvate-flavodoxin oxidoreductase activity
MSSIH_RS20600	COG0018	arginyl-trna synthetase
MSSIH_RS20645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS20650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS20655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS20660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSSIH_RS20675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSSIH_RS20695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSSIH_RS20720	COG1260	myo-inositol-1-phosphate synthase
MSSIH_RS20725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSSIH_RS20750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSSIH_RS20755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSSIH_RS20760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MSSIH_RS20770	COG0248	Ppx GppA phosphatase
MSSIH_RS20785	COG0459	protein refolding
MSSIH_RS20800	COG0076	glutamate decarboxylase activity
MSSIH_RS20805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family