locus-tag	class	description
MFER_RS00005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MFER_RS00025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MFER_RS00055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MFER_RS00090	COG1968	undecaprenyl-diphosphatase activity
MFER_RS00100	COG2971	BadF BadG BcrA BcrD
MFER_RS00115	COG0436	Aminotransferase
MFER_RS00155	COG0514	ATP-dependent DNA helicase (RecQ)
MFER_RS00160	COG0318	PFAM AMP-dependent synthetase and ligase
MFER_RS00170	COG0045	succinate-CoA ligase (ADP-forming) activity
MFER_RS00180	COG1013	pyruvate-flavodoxin oxidoreductase activity
MFER_RS00185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MFER_RS00185	COG0674	pyruvate-flavodoxin oxidoreductase activity
MFER_RS00200	COG0450	alkyl hydroperoxide reductase
MFER_RS00210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MFER_RS00225	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MFER_RS00245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MFER_RS00255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MFER_RS00265	COG0151	Belongs to the GarS family
MFER_RS00270	COG0028	Belongs to the TPP enzyme family
MFER_RS00280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MFER_RS00305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MFER_RS00310	COG1121	(ABC) transporter
MFER_RS00320	COG0864	Transcriptional regulator
MFER_RS00345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MFER_RS00355	COG0107	imidazoleglycerol-phosphate synthase activity
MFER_RS00375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MFER_RS00380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MFER_RS00385	COG0459	protein refolding
MFER_RS00395	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
MFER_RS00400	COG0129	dihydroxy-acid dehydratase activity
MFER_RS00410	COG0018	arginyl-trna synthetase
MFER_RS00415	COG0459	protein refolding
MFER_RS00420	COG0183	Belongs to the thiolase family
MFER_RS00425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MFER_RS00440	COG0731	radical SAM domain protein
MFER_RS00445	COG1053	succinate dehydrogenase
MFER_RS00450	COG0284	orotidine-5'-phosphate decarboxylase activity
MFER_RS00460	COG1899	peptidyl-lysine modification to peptidyl-hypusine
MFER_RS00470	COG2151	metal-sulfur cluster biosynthetic enzyme
MFER_RS00485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MFER_RS00490	COG0159	tryptophan synthase activity
MFER_RS00495	COG0133	tryptophan synthase activity
MFER_RS00500	COG0135	phosphoribosylanthranilate isomerase activity
MFER_RS00505	COG0134	indole-3-glycerol-phosphate synthase activity
MFER_RS00510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MFER_RS00510	COG0512	Glutamine amidotransferase of anthranilate synthase
MFER_RS00515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MFER_RS00535	COG1110	DNA topoisomerase II activity
MFER_RS00540	COG0409	Hydrogenase expression formation protein
MFER_RS00550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MFER_RS00565	COG1201	RNA secondary structure unwinding
MFER_RS00590	COG0430	RNA-3'-phosphate cyclase activity
MFER_RS00595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MFER_RS00595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MFER_RS00600	COG0439	Biotin carboxylase
MFER_RS00610	COG2264	protein methyltransferase activity
MFER_RS00625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MFER_RS00635	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MFER_RS00635	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MFER_RS00640	COG0076	glutamate decarboxylase activity
MFER_RS00645	COG0574	Belongs to the PEP-utilizing enzyme family
MFER_RS00645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MFER_RS00650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MFER_RS00660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MFER_RS00670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MFER_RS00675	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MFER_RS00690	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MFER_RS00705	COG0521	Mo-molybdopterin cofactor biosynthetic process
MFER_RS00735	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MFER_RS00755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MFER_RS00775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MFER_RS00800	COG0126	phosphoglycerate kinase activity
MFER_RS00815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MFER_RS00820	COG0012	GTP binding
MFER_RS00830	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MFER_RS00845	COG0552	protein localization to endoplasmic reticulum
MFER_RS00905	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MFER_RS00910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MFER_RS00970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MFER_RS00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MFER_RS00985	COG1321	iron dependent repressor
MFER_RS00995	COG0746	molybdenum cofactor guanylyltransferase activity
MFER_RS01000	COG0516	GMP reductase activity
MFER_RS01000	COG0517	IMP dehydrogenase activity
MFER_RS01005	COG1891	lyase activity
MFER_RS01020	COG0463	Glycosyl transferase, family 2
MFER_RS01050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MFER_RS01060	COG0066	3-isopropylmalate dehydratase activity
MFER_RS01070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MFER_RS01105	COG0101	tRNA pseudouridine synthase activity
MFER_RS01145	COG1011	Hydrolase
MFER_RS01155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MFER_RS01165	COG0438	transferase activity, transferring glycosyl groups
MFER_RS01170	COG0247	lactate metabolic process
MFER_RS01185	COG0717	Belongs to the dCTP deaminase family
MFER_RS01190	COG0423	glycine-tRNA ligase activity
MFER_RS01200	COG0720	synthase
MFER_RS01205	COG0602	queuosine metabolic process
MFER_RS01210	COG0517	IMP dehydrogenase activity
MFER_RS01215	COG0517	IMP dehydrogenase activity
MFER_RS01215	COG0516	GMP reductase activity
MFER_RS01220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MFER_RS01220	COG0517	IMP dehydrogenase activity
MFER_RS01220	COG0617	tRNA 3'-terminal CCA addition
MFER_RS01225	COG0517	IMP dehydrogenase activity
MFER_RS01230	COG0517	IMP dehydrogenase activity
MFER_RS01240	COG1605	Chorismate mutase
MFER_RS01240	COG0077	Prephenate dehydratase
MFER_RS01255	COG0306	phosphate transporter
MFER_RS01260	COG0516	GMP reductase activity
MFER_RS01260	COG0517	IMP dehydrogenase activity
MFER_RS01270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MFER_RS01285	COG1881	PFAM PEBP family protein
MFER_RS01290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MFER_RS01300	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MFER_RS01335	COG1144	Oxidoreductase
MFER_RS01340	COG0674	pyruvate-flavodoxin oxidoreductase activity
MFER_RS01345	COG1013	pyruvate-flavodoxin oxidoreductase activity
MFER_RS01350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MFER_RS01360	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MFER_RS01370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MFER_RS01375	COG0581	inorganic phosphate transmembrane transporter activity
MFER_RS01380	COG0573	inorganic phosphate transmembrane transporter activity
MFER_RS01385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MFER_RS01425	COG0778	Nitroreductase
MFER_RS01430	COG1088	dTDP-glucose 4,6-dehydratase activity
MFER_RS01430	COG1088	dTDP-glucose 4,6-dehydratase activity
MFER_RS01440	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MFER_RS01455	COG1091	dTDP-4-dehydrorhamnose reductase activity
MFER_RS01460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MFER_RS01505	COG0303	'Molybdopterin
MFER_RS01515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MFER_RS01530	COG0505	Belongs to the CarA family
MFER_RS01535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MFER_RS01560	COG2894	cell division
MFER_RS01565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MFER_RS01570	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
MFER_RS01590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MFER_RS01605	COG0517	IMP dehydrogenase activity
MFER_RS01605	COG1125	glycine betaine transport
MFER_RS01610	COG0107	imidazoleglycerol-phosphate synthase activity
MFER_RS01620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MFER_RS01625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MFER_RS01625	COG0778	Nitroreductase
MFER_RS01640	COG0131	Imidazoleglycerol-phosphate dehydratase
MFER_RS01685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MFER_RS01695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MFER_RS01700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MFER_RS01715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MFER_RS01725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MFER_RS01760	COG0006	proline dipeptidase activity
MFER_RS01790	COG2226	methyltransferase
MFER_RS01810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MFER_RS01815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MFER_RS01820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MFER_RS01830	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MFER_RS01855	COG0037	tRNA processing
MFER_RS01860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MFER_RS01865	COG0525	valine-tRNA ligase activity
MFER_RS01905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MFER_RS01910	COG0826	peptidase U32
MFER_RS01935	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MFER_RS01940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MFER_RS01950	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
MFER_RS01950	COG0028	Belongs to the TPP enzyme family
MFER_RS01960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MFER_RS01965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MFER_RS01970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MFER_RS01975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MFER_RS01985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MFER_RS01990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MFER_RS02015	COG1522	sequence-specific DNA binding
MFER_RS02020	COG0375	protein maturation
MFER_RS02040	COG1515	deoxyribonuclease V activity
MFER_RS02045	COG0446	pyridine nucleotide-disulphide oxidoreductase
MFER_RS02060	COG4555	ABC transporter
MFER_RS02075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MFER_RS02080	COG0470	DNA polymerase III
MFER_RS02080	COG1067	ATP-dependent peptidase activity
MFER_RS02095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MFER_RS02100	COG0674	pyruvate-flavodoxin oxidoreductase activity
MFER_RS02125	COG0460	homoserine dehydrogenase
MFER_RS02130	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MFER_RS02135	COG0504	CTP synthase activity
MFER_RS02145	COG1592	Rubrerythrin
MFER_RS02145	COG1773	rubredoxin
MFER_RS02150	COG0426	domain, Protein
MFER_RS02160	COG1956	GAF domain-containing protein
MFER_RS02175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MFER_RS02180	COG1429	ligase activity, forming nitrogen-metal bonds
MFER_RS02185	COG0084	hydrolase, TatD family'
MFER_RS02195	COG2255	four-way junction helicase activity
MFER_RS02200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MFER_RS02230	COG0539	negative regulation of cytoplasmic translation
MFER_RS02235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MFER_RS02255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MFER_RS02260	COG0105	UTP biosynthetic process
MFER_RS02295	COG1323	Belongs to the UPF0348 family
MFER_RS02305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MFER_RS02325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MFER_RS02330	COG0606	chelatase, subunit chli
MFER_RS02345	COG0473	3-isopropylmalate dehydrogenase activity
MFER_RS02345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MFER_RS02350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MFER_RS02350	COG0730	response to heat
MFER_RS02380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MFER_RS02390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MFER_RS02425	COG1606	tRNA processing
MFER_RS02465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MFER_RS02485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MFER_RS02490	COG0393	Putative heavy-metal-binding
MFER_RS02500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MFER_RS02510	COG0585	pseudouridine synthase activity
MFER_RS02525	COG1131	(ABC) transporter
MFER_RS02540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MFER_RS02560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MFER_RS02565	COG1793	dna ligase
MFER_RS02575	COG0252	asparaginase activity
MFER_RS02580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MFER_RS02590	COG0519	Catalyzes the synthesis of GMP from XMP
MFER_RS02590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MFER_RS02595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MFER_RS02595	COG0519	Catalyzes the synthesis of GMP from XMP
MFER_RS02610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MFER_RS02635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MFER_RS02680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MFER_RS02700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MFER_RS02705	COG0501	Belongs to the peptidase M48B family
MFER_RS02710	COG0475	glutathione-regulated potassium exporter activity
MFER_RS02710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MFER_RS02715	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MFER_RS02730	COG1429	ligase activity, forming nitrogen-metal bonds
MFER_RS02735	COG1254	Belongs to the acylphosphatase family
MFER_RS02765	COG3769	mannosylglycerate metabolic process
MFER_RS02775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MFER_RS02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MFER_RS02810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MFER_RS02815	COG1121	(ABC) transporter
MFER_RS02835	COG2226	methyltransferase
MFER_RS02840	COG0445	tRNA wobble uridine modification
MFER_RS02850	COG2814	Major facilitator Superfamily
MFER_RS02855	COG2264	protein methyltransferase activity
MFER_RS02895	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MFER_RS02900	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MFER_RS02920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MFER_RS02925	COG1266	CAAX protease self-immunity
MFER_RS02955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MFER_RS02960	COG0066	3-isopropylmalate dehydratase activity
MFER_RS02965	COG0473	3-isopropylmalate dehydrogenase activity
MFER_RS02970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MFER_RS02975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MFER_RS02990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MFER_RS02995	COG0017	Asparaginyl-tRNA synthetase
MFER_RS03005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MFER_RS03015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MFER_RS03020	COG0084	hydrolase, TatD family'
MFER_RS03040	COG1830	Aldolase
MFER_RS03045	COG1465	3-dehydroquinate synthase
MFER_RS03050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MFER_RS03070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MFER_RS03070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MFER_RS03085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MFER_RS03100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MFER_RS03120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MFER_RS03140	COG0367	asparagine synthase
MFER_RS03150	COG0287	Prephenate dehydrogenase
MFER_RS03160	COG0028	Belongs to the TPP enzyme family
MFER_RS03170	COG3260	NADH ubiquinone oxidoreductase 20
MFER_RS03175	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MFER_RS03175	COG3261	NADH dehydrogenase
MFER_RS03180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MFER_RS03200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MFER_RS03205	COG1007	ATP synthesis coupled electron transport
MFER_RS03210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MFER_RS03215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MFER_RS03230	COG1260	myo-inositol-1-phosphate synthase
MFER_RS03240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MFER_RS03265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MFER_RS03290	COG1358	cellular component organization or biogenesis
MFER_RS03295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MFER_RS03300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MFER_RS03305	COG0085	RNA polymerase activity
MFER_RS03410	COG2079	MmgE PrpD family protein
MFER_RS03440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MFER_RS03445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MFER_RS03450	COG0527	aspartate kinase activity
MFER_RS03460	COG1605	Chorismate mutase
MFER_RS03460	COG0077	Prephenate dehydratase
MFER_RS03475	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MFER_RS03480	COG0438	transferase activity, transferring glycosyl groups
MFER_RS03485	COG0315	cyclic pyranopterin monophosphate synthase activity
MFER_RS03515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MFER_RS03530	COG1012	belongs to the aldehyde dehydrogenase family
MFER_RS03535	COG3383	formate dehydrogenase (NAD+) activity
MFER_RS03550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MFER_RS03555	COG0179	Fumarylacetoacetate (FAA) hydrolase
MFER_RS03560	COG2226	methyltransferase
MFER_RS03590	COG0402	S-adenosylhomocysteine deaminase activity
MFER_RS03630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MFER_RS03635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MFER_RS03665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MFER_RS03670	COG1993	acr, cog1993
MFER_RS03690	COG4656	Part of a membrane complex involved in electron transport
MFER_RS03695	COG0243	molybdopterin cofactor binding
MFER_RS03705	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
MFER_RS03710	COG3259	Nickel-dependent hydrogenase
MFER_RS03750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MFER_RS03760	COG2048	Heterodisulfide reductase, subunit B
MFER_RS03780	COG0157	Belongs to the NadC ModD family
MFER_RS03790	COG0668	transmembrane transport
MFER_RS03800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MFER_RS03810	COG1980	fructose-bisphosphate aldolase activity
MFER_RS03830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MFER_RS03835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MFER_RS03845	COG0495	leucyl-tRNA aminoacylation
MFER_RS03855	COG0482	sulfurtransferase activity
MFER_RS03860	COG1181	Belongs to the D-alanine--D-alanine ligase family
MFER_RS03865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MFER_RS03870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MFER_RS03885	COG0719	Fe-S assembly protein
MFER_RS03890	COG0396	ATPase activity
MFER_RS03905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MFER_RS03930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MFER_RS03940	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MFER_RS04010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MFER_RS04015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MFER_RS04020	COG0489	protein tyrosine kinase activity
MFER_RS04025	COG1342	Belongs to the UPF0251 family
MFER_RS04035	COG0310	cobalt ion transport
MFER_RS04080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MFER_RS04090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MFER_RS04115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MFER_RS04120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MFER_RS04130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MFER_RS04200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MFER_RS04205	COG1185	polyribonucleotide nucleotidyltransferase activity
MFER_RS04300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MFER_RS04335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MFER_RS04340	COG0088	Forms part of the polypeptide exit tunnel
MFER_RS04345	COG0089	rRNA binding
MFER_RS04350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MFER_RS04355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MFER_RS04365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MFER_RS04370	COG0255	Belongs to the universal ribosomal protein uL29 family
MFER_RS04385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MFER_RS04390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MFER_RS04405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MFER_RS04415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MFER_RS04440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MFER_RS04450	COG0200	Binds to the 23S rRNA
MFER_RS04475	COG0563	adenylate kinase activity
MFER_RS04485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MFER_RS04495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MFER_RS04500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MFER_RS04505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MFER_RS04515	COG0200	Binds to the 23S rRNA
MFER_RS04520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MFER_RS04525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MFER_RS04545	COG0148	phosphopyruvate hydratase activity
MFER_RS04550	COG0052	Belongs to the universal ribosomal protein uS2 family
MFER_RS04555	COG1355	regulation of microtubule-based process
MFER_RS04565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MFER_RS04570	COG1304	FMN binding
MFER_RS04590	COG0436	Aminotransferase
MFER_RS04595	COG2033	superoxide reductase activity
MFER_RS04620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MFER_RS04625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MFER_RS04630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MFER_RS04635	COG0671	phosphoesterase, PA-phosphatase related
MFER_RS04665	COG1077	Cell shape determining protein MreB Mrl
MFER_RS04670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MFER_RS04675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MFER_RS04685	COG1121	(ABC) transporter
MFER_RS04695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MFER_RS04700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MFER_RS04750	COG0235	Class ii aldolase
MFER_RS04755	COG0322	excinuclease ABC activity
MFER_RS04835	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
MFER_RS04845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MFER_RS04875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MFER_RS04890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MFER_RS04895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MFER_RS04900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MFER_RS04925	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MFER_RS04930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MFER_RS04945	COG0500	methyltransferase
MFER_RS04970	COG1229	Formylmethanofuran dehydrogenase subunit A
MFER_RS04980	COG3383	formate dehydrogenase (NAD+) activity
MFER_RS04985	COG3842	ATPase activity
MFER_RS04990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MFER_RS04995	COG0725	ABC transporter, periplasmic molybdate-binding protein
MFER_RS05000	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MFER_RS05005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MFER_RS05020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MFER_RS05030	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MFER_RS05030	COG1918	ferrous iron import across plasma membrane
MFER_RS05060	COG1131	(ABC) transporter
MFER_RS05100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MFER_RS05105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MFER_RS05130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MFER_RS05135	COG2890	protein-(glutamine-N5) methyltransferase activity
MFER_RS05140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MFER_RS05200	COG1185	polyribonucleotide nucleotidyltransferase activity
MFER_RS05215	COG1379	DNA repair
MFER_RS05225	COG1032	radical SAM domain protein
MFER_RS05230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MFER_RS05250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MFER_RS05260	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
MFER_RS05265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MFER_RS05280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MFER_RS05285	COG0351	phosphomethylpyrimidine kinase
MFER_RS05300	COG0442	prolyl-tRNA aminoacylation
MFER_RS05325	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MFER_RS05330	COG1266	CAAX protease self-immunity
MFER_RS05350	COG0864	Transcriptional regulator
MFER_RS05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MFER_RS05360	COG0298	carbon dioxide binding
MFER_RS05385	COG2878	Part of a membrane complex involved in electron transport
MFER_RS05400	COG1809	phosphosulfolactate synthase activity
MFER_RS05415	COG0024	Methionine aminopeptidase
MFER_RS05475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MFER_RS05475	COG1328	CTP reductase activity
MFER_RS05530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MFER_RS05535	COG0463	Glycosyl transferase, family 2
MFER_RS05540	COG1088	dTDP-glucose 4,6-dehydratase activity
MFER_RS05580	COG1335	isochorismatase
MFER_RS05590	COG2144	transferase activity, transferring acyl groups
MFER_RS05620	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MFER_RS05630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MFER_RS05640	COG1192	Involved in chromosome partitioning
MFER_RS05655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MFER_RS05670	COG0069	glutamate synthase activity
MFER_RS05675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MFER_RS05675	COG0574	Belongs to the PEP-utilizing enzyme family
MFER_RS05680	COG0501	Belongs to the peptidase M48B family
MFER_RS05690	COG0710	3-dehydroquinate dehydratase activity
MFER_RS05700	COG0347	Belongs to the P(II) protein family
MFER_RS05705	COG0174	glutamine synthetase
MFER_RS05710	COG0531	amino acid
MFER_RS05720	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MFER_RS05725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MFER_RS05730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MFER_RS05760	COG0730	response to heat
MFER_RS05765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MFER_RS05785	COG0586	Pfam SNARE associated Golgi protein
MFER_RS05800	COG0009	L-threonylcarbamoyladenylate synthase
MFER_RS05805	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MFER_RS05820	COG1203	CRISPR-associated helicase, Cas3
MFER_RS05860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MFER_RS05925	COG0167	dihydroorotate dehydrogenase activity
MFER_RS05940	COG1191	sigma factor activity
MFER_RS05945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MFER_RS05955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MFER_RS05990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MFER_RS05995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MFER_RS06000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MFER_RS06010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MFER_RS06020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MFER_RS06030	COG0543	2 iron, 2 sulfur cluster binding
MFER_RS06035	COG0628	permease
MFER_RS06040	COG0037	tRNA processing
MFER_RS06045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MFER_RS06075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MFER_RS06080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MFER_RS06105	COG1458	PINc domain ribonuclease
MFER_RS06110	COG0124	histidyl-tRNA synthetase
MFER_RS06115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MFER_RS06120	COG4956	integral membrane protein (PIN domain superfamily)
MFER_RS06135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MFER_RS06145	COG0180	Tryptophanyl-tRNA synthetase
MFER_RS06165	COG0010	Belongs to the arginase family
MFER_RS06180	COG0483	inositol monophosphate 1-phosphatase activity
MFER_RS06185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MFER_RS06195	COG0181	hydroxymethylbilane synthase activity
MFER_RS06205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MFER_RS06220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MFER_RS06220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MFER_RS06250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MFER_RS06265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MFER_RS06295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MFER_RS06305	COG0517	IMP dehydrogenase activity
MFER_RS06305	COG0516	GMP reductase activity
MFER_RS06310	COG0140	phosphoribosyl-ATP diphosphatase activity
MFER_RS06315	COG1691	(AIR) carboxylase
MFER_RS06320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MFER_RS06345	COG0463	Glycosyl transferase, family 2
MFER_RS06350	COG0301	tRNA thio-modification
MFER_RS06350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MFER_RS06360	COG2045	Belongs to the ComB family
MFER_RS06390	COG0037	tRNA processing
MFER_RS06395	COG0011	TIGRFAM Protein of
MFER_RS06430	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MFER_RS06460	COG0113	porphobilinogen synthase activity
MFER_RS06475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MFER_RS06480	COG0517	IMP dehydrogenase activity
MFER_RS06480	COG0516	GMP reductase activity
MFER_RS06485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MFER_RS06490	COG0312	modulator of DNA gyrase
MFER_RS06495	COG2078	PFAM AMMECR1 domain protein
MFER_RS06500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MFER_RS06505	COG0071	Belongs to the small heat shock protein (HSP20) family
MFER_RS06525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MFER_RS06535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MFER_RS06540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MFER_RS06545	COG0473	3-isopropylmalate dehydrogenase activity
MFER_RS06555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MFER_RS06575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MFER_RS06585	COG0343	queuine tRNA-ribosyltransferase activity
MFER_RS06630	COG1078	dGTPase activity
MFER_RS06635	COG0314	molybdopterin synthase activity
MFER_RS06645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MFER_RS06650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MFER_RS06655	COG0589	response to stress
MFER_RS06675	COG1587	Uroporphyrinogen-III synthase
MFER_RS06705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MFER_RS06720	COG2234	aminopeptidase activity
MFER_RS06725	COG1199	ATP-dependent helicase activity
MFER_RS06745	COG2843	Capsule synthesis protein
MFER_RS06790	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
MFER_RS06820	COG1429	ligase activity, forming nitrogen-metal bonds
MFER_RS06835	COG1429	ligase activity, forming nitrogen-metal bonds
MFER_RS06850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MFER_RS06875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MFER_RS06880	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MFER_RS06880	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MFER_RS06885	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MFER_RS06920	COG2169	Transcriptional regulator
MFER_RS06920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MFER_RS06930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MFER_RS06950	COG1215	transferase activity, transferring glycosyl groups