locus-tag	class	description
MPE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MPE_RS00025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MPE_RS00030	COG0732	type I restriction modification DNA specificity domain
MPE_RS00035	COG0419	ATPase involved in DNA repair
MPE_RS00050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MPE_RS00055	COG3634	alkyl hydroperoxide reductase activity
MPE_RS00060	COG2259	Doxx family
MPE_RS00065	COG4575	ribosome binding
MPE_RS00080	COG2116	formate transmembrane transporter activity
MPE_RS00085	COG4941	Belongs to the sigma-70 factor family
MPE_RS00095	COG3795	YCII-related domain
MPE_RS00100	COG3795	YCII-related domain
MPE_RS00105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MPE_RS00110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPE_RS00115	COG1396	sequence-specific DNA binding
MPE_RS00120	COG1045	serine acetyltransferase
MPE_RS00170	COG4221	oxidoreductase activity
MPE_RS00180	COG2995	paraquat-inducible protein a
MPE_RS00185	COG2995	paraquat-inducible protein a
MPE_RS00190	COG3008	intermembrane lipid transfer
MPE_RS00190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPE_RS00220	COG0392	lysyltransferase activity
MPE_RS00225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MPE_RS00230	COG3568	Endonuclease Exonuclease Phosphatase
MPE_RS00235	COG2176	DNA-directed DNA polymerase activity
MPE_RS00260	COG0400	carboxylic ester hydrolase activity
MPE_RS00275	COG1846	Transcriptional regulator
MPE_RS00280	COG1764	response to oxidative stress
MPE_RS00285	COG1950	PFAM Membrane protein of
MPE_RS00290	COG4783	chaperone-mediated protein folding
MPE_RS00300	COG0315	cyclic pyranopterin monophosphate synthase activity
MPE_RS00305	COG3307	-O-antigen
MPE_RS00315	COG1234	tRNA 3'-trailer cleavage
MPE_RS00320	COG1716	ATPase activity
MPE_RS00325	COG0631	protein serine/threonine phosphatase activity
MPE_RS00330	COG0515	serine threonine protein kinase
MPE_RS00330	COG2815	serine threonine protein kinase
MPE_RS00335	COG0861	Integral membrane protein TerC family
MPE_RS00340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MPE_RS00345	COG0045	succinate-CoA ligase (ADP-forming) activity
MPE_RS00355	COG2137	regulation of response to DNA damage stimulus
MPE_RS00360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MPE_RS00380	COG0772	Belongs to the SEDS family
MPE_RS00385	COG0768	penicillin binding
MPE_RS00400	COG1077	Cell shape determining protein MreB Mrl
MPE_RS00405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MPE_RS00410	COG0154	amidase activity
MPE_RS00415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MPE_RS00425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MPE_RS00445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPE_RS00470	COG2818	Glycosylase
MPE_RS00480	COG2205	protein histidine kinase activity
MPE_RS00530	COG0038	chloride channel
MPE_RS00540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MPE_RS00540	COG0475	glutathione-regulated potassium exporter activity
MPE_RS00545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPE_RS00550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPE_RS00555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPE_RS00560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPE_RS00565	COG1116	anion transmembrane transporter activity
MPE_RS00585	COG0450	alkyl hydroperoxide reductase
MPE_RS00590	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MPE_RS00595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MPE_RS00605	COG4208	sulfate ABC transporter
MPE_RS00610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MPE_RS00615	COG0583	DNA-binding transcription factor activity
MPE_RS00620	COG0210	DNA helicase
MPE_RS00625	COG0679	Auxin Efflux Carrier
MPE_RS00630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MPE_RS00640	COG0765	amino acid transport
MPE_RS00645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MPE_RS00650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MPE_RS00655	COG0745	RESPONSE REGULATOR receiver
MPE_RS00660	COG2205	protein histidine kinase activity
MPE_RS00670	COG0583	DNA-binding transcription factor activity
MPE_RS00695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MPE_RS00730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MPE_RS00735	COG1137	ATPase activity
MPE_RS00745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MPE_RS00755	COG0018	arginyl-trna synthetase
MPE_RS00775	COG0583	DNA-binding transcription factor activity
MPE_RS00785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MPE_RS00805	COG3590	peptidase
MPE_RS00810	COG0644	oxidoreductase
MPE_RS00815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPE_RS00830	COG0646	methionine synthase
MPE_RS00830	COG1410	methionine synthase
MPE_RS00840	COG0606	chelatase, subunit chli
MPE_RS00850	COG0004	ammonium transporteR
MPE_RS00860	COG3158	transport of potassium into the cell
MPE_RS00870	COG3268	Saccharopine dehydrogenase
MPE_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS00885	COG3135	benzoate transporter
MPE_RS00890	COG0189	ligase activity
MPE_RS00895	COG0488	(ABC) transporter
MPE_RS00905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS00915	COG1794	racemase activity, acting on amino acids and derivatives
MPE_RS00920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS00925	COG0384	phenazine biosynthesis protein PhzF
MPE_RS00945	COG0356	it plays a direct role in the translocation of protons across the membrane
MPE_RS00955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MPE_RS00960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPE_RS00965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MPE_RS00970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MPE_RS00975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MPE_RS00980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MPE_RS00990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MPE_RS01000	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MPE_RS01005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MPE_RS01010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MPE_RS01025	COG0280	phosphate acetyltransferase
MPE_RS01025	COG0281	malic enzyme
MPE_RS01040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MPE_RS01045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MPE_RS01055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MPE_RS01080	COG0495	leucyl-tRNA aminoacylation
MPE_RS01095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MPE_RS01100	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MPE_RS01105	COG0735	belongs to the Fur family
MPE_RS01110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MPE_RS01120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MPE_RS01125	COG0598	Magnesium transport protein CorA
MPE_RS01140	COG0300	oxidoreductase activity
MPE_RS01160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPE_RS01175	COG0386	Belongs to the glutathione peroxidase family
MPE_RS01190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MPE_RS01200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MPE_RS01215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MPE_RS01235	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MPE_RS01245	COG0473	3-isopropylmalate dehydrogenase activity
MPE_RS01260	COG0006	proline dipeptidase activity
MPE_RS01265	COG0667	Aldo Keto reductase
MPE_RS01280	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MPE_RS01285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MPE_RS01290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MPE_RS01295	COG1404	Belongs to the peptidase S8 family
MPE_RS01305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MPE_RS01305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MPE_RS01335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MPE_RS01340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MPE_RS01360	COG5000	phosphorelay sensor kinase activity
MPE_RS01365	COG2204	response regulator
MPE_RS01375	COG1862	Preprotein translocase
MPE_RS01380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MPE_RS01385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MPE_RS01395	COG2922	Belongs to the Smg family
MPE_RS01400	COG0758	DNA mediated transformation
MPE_RS01405	COG1652	LysM domain
MPE_RS01410	COG0242	peptide deformylase activity
MPE_RS01415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MPE_RS01420	COG0501	Belongs to the peptidase M48B family
MPE_RS01440	COG0126	phosphoglycerate kinase activity
MPE_RS01445	COG0469	pyruvate kinase activity
MPE_RS01455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MPE_RS01470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MPE_RS01475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MPE_RS01480	COG0009	L-threonylcarbamoyladenylate synthase
MPE_RS01500	COG1214	PFAM Peptidase M22, glycoprotease
MPE_RS01510	COG1573	uracil-dna glycosylase
MPE_RS01515	COG3300	MHYT domain
MPE_RS01515	COG5001	Diguanylate cyclase
MPE_RS01520	COG0598	Magnesium transport protein CorA
MPE_RS01550	COG1686	Belongs to the peptidase S11 family
MPE_RS01555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MPE_RS01560	COG2921	Belongs to the UPF0250 family
MPE_RS01565	COG4555	ABC transporter
MPE_RS01575	COG0321	lipoyl(octanoyl) transferase activity
MPE_RS01580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MPE_RS01605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPE_RS01620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MPE_RS01630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MPE_RS01660	COG2255	four-way junction helicase activity
MPE_RS01690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPE_RS01695	COG0179	Fumarylacetoacetate (FAA) hydrolase
MPE_RS01700	COG0840	transmembrane signaling receptor activity
MPE_RS01710	COG3383	formate dehydrogenase (NAD+) activity
MPE_RS01740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPE_RS01745	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS01750	COG1522	sequence-specific DNA binding
MPE_RS01760	COG3186	Phenylalanine-4-hydroxylase
MPE_RS01775	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MPE_RS01790	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS01810	COG2197	response regulator
MPE_RS01815	COG3851	Histidine kinase
MPE_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
MPE_RS01850	COG3284	Transcriptional regulator
MPE_RS01855	COG2119	membrane
MPE_RS01880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MPE_RS01910	COG3039	Transposase
MPE_RS01960	COG2072	flavoprotein involved in K transport
MPE_RS01975	COG3284	Transcriptional regulator
MPE_RS02035	COG3971	2-oxopent-4-enoate hydratase activity
MPE_RS02050	COG0668	transmembrane transport
MPE_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS02065	COG1024	Enoyl-CoA hydratase
MPE_RS02075	COG0183	Belongs to the thiolase family
MPE_RS02080	COG1024	Enoyl-CoA hydratase
MPE_RS02080	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPE_RS02090	COG1960	acyl-CoA dehydrogenase activity
MPE_RS02105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPE_RS02110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MPE_RS02135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MPE_RS02140	COG0459	protein refolding
MPE_RS02150	COG1752	Esterase of the alpha-beta hydrolase superfamily
MPE_RS02155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MPE_RS02165	COG1333	cytochrome c biogenesis protein
MPE_RS02170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MPE_RS02180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MPE_RS02185	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MPE_RS02195	COG5265	(ABC) transporter
MPE_RS02210	COG4681	YaeQ
MPE_RS02215	COG0583	DNA-binding transcription factor activity
MPE_RS02220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPE_RS02225	COG0765	amino acid transport
MPE_RS02230	COG0765	amino acid transport
MPE_RS02235	COG1126	abc transporter atp-binding protein
MPE_RS02245	COG0418	dihydroorotase activity
MPE_RS02260	COG2814	Major facilitator Superfamily
MPE_RS02270	COG2001	Belongs to the MraZ family
MPE_RS02275	COG0275	rRNA processing
MPE_RS02280	COG3116	cell division
MPE_RS02290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MPE_RS02295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MPE_RS02300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MPE_RS02305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MPE_RS02310	COG0772	Belongs to the SEDS family
MPE_RS02315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MPE_RS02320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MPE_RS02325	COG1181	Belongs to the D-alanine--D-alanine ligase family
MPE_RS02330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MPE_RS02340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MPE_RS02345	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MPE_RS02390	COG4585	Histidine kinase
MPE_RS02395	COG2197	response regulator
MPE_RS02400	COG3284	Transcriptional regulator
MPE_RS02415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MPE_RS02420	COG4589	Belongs to the CDS family
MPE_RS02430	COG0138	bifunctional purine biosynthesis protein purh
MPE_RS02435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MPE_RS02440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MPE_RS02465	COG4221	oxidoreductase activity
MPE_RS02470	COG1230	cation diffusion facilitator family transporter
MPE_RS02505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MPE_RS02515	COG1309	transcriptional regulator
MPE_RS02525	COG0494	nUDIX hydrolase
MPE_RS02530	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MPE_RS02535	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MPE_RS02545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MPE_RS02565	COG0142	geranyltranstransferase activity
MPE_RS02570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MPE_RS02575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MPE_RS02580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MPE_RS02585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MPE_RS02595	COG0494	nUDIX hydrolase
MPE_RS02600	COG0442	prolyl-tRNA aminoacylation
MPE_RS02605	COG0741	lytic transglycosylase activity
MPE_RS02615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MPE_RS02625	COG2890	protein-(glutamine-N5) methyltransferase activity
MPE_RS02630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MPE_RS02635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MPE_RS02645	COG0602	queuosine metabolic process
MPE_RS02650	COG0720	synthase
MPE_RS02660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MPE_RS02665	COG0156	8-amino-7-oxononanoate synthase activity
MPE_RS02670	COG1272	protein, Hemolysin III
MPE_RS02675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MPE_RS02775	COG4221	oxidoreductase activity
MPE_RS02785	COG0037	tRNA processing
MPE_RS02800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MPE_RS02805	COG0484	heat shock protein binding
MPE_RS02835	COG1677	Flagellar hook-basal body complex protein FliE
MPE_RS02890	COG1338	Plays a role in the flagellum-specific transport system
MPE_RS02895	COG1987	bacterial-type flagellum assembly
MPE_RS02915	COG3813	Protein conserved in bacteria
MPE_RS02935	COG0745	RESPONSE REGULATOR receiver
MPE_RS02940	COG2198	Histidine kinase
MPE_RS02940	COG0643	Histidine kinase
MPE_RS02945	COG0840	transmembrane signaling receptor activity
MPE_RS02955	COG1741	Belongs to the pirin family
MPE_RS02970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MPE_RS03005	COG1024	Enoyl-CoA hydratase
MPE_RS03015	COG1012	belongs to the aldehyde dehydrogenase family
MPE_RS03020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MPE_RS03035	COG0438	transferase activity, transferring glycosyl groups
MPE_RS03040	COG1215	transferase activity, transferring glycosyl groups
MPE_RS03055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MPE_RS03060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MPE_RS03065	COG1086	Polysaccharide biosynthesis protein
MPE_RS03085	COG0463	Glycosyl transferase, family 2
MPE_RS03100	COG2226	methyltransferase
MPE_RS03165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MPE_RS03170	COG0513	Belongs to the DEAD box helicase family
MPE_RS03175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MPE_RS03180	COG0424	maF-like protein
MPE_RS03190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MPE_RS03195	COG0416	fatty acid biosynthetic process
MPE_RS03200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPE_RS03205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MPE_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS03215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MPE_RS03220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MPE_RS03245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPE_RS03250	COG0481	GTPase activity
MPE_RS03255	COG0681	Belongs to the peptidase S26 family
MPE_RS03265	COG0571	ribonuclease III activity
MPE_RS03270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MPE_RS03275	COG1381	Involved in DNA repair and RecF pathway recombination
MPE_RS03280	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MPE_RS03285	COG0736	holo-[acyl-carrier-protein] synthase activity
MPE_RS03290	COG1472	Belongs to the glycosyl hydrolase 3 family
MPE_RS03295	COG1530	ribonuclease E activity
MPE_RS03315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MPE_RS03315	COG0616	signal peptide processing
MPE_RS03325	COG1652	LysM domain
MPE_RS03330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPE_RS03335	COG0830	nickel cation binding
MPE_RS03340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MPE_RS03350	COG0804	urea catabolic process
MPE_RS03355	COG0832	Belongs to the urease beta subunit family
MPE_RS03360	COG0831	urea catabolic process
MPE_RS03365	COG2198	Histidine kinase
MPE_RS03365	COG0784	Response regulator, receiver
MPE_RS03365	COG5002	protein histidine kinase activity
MPE_RS03400	COG0300	oxidoreductase activity
MPE_RS03520	COG0415	Belongs to the DNA photolyase family
MPE_RS03525	COG1678	Uncharacterized ACR, COG1678
MPE_RS03530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MPE_RS03535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MPE_RS03540	COG0540	Belongs to the ATCase OTCase family
MPE_RS03560	COG0588	phosphoglycerate mutase activity
MPE_RS03565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPE_RS03570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MPE_RS03575	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MPE_RS03580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MPE_RS03605	COG1215	transferase activity, transferring glycosyl groups
MPE_RS03630	COG2755	lipolytic protein G-D-S-L family
MPE_RS03630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MPE_RS03670	COG1215	transferase activity, transferring glycosyl groups
MPE_RS03675	COG0489	protein tyrosine kinase activity
MPE_RS03695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MPE_RS03705	COG0829	nickel cation binding
MPE_RS03720	COG0583	DNA-binding transcription factor activity
MPE_RS03745	COG0840	transmembrane signaling receptor activity
MPE_RS03755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS03770	COG2010	Cytochrome c
MPE_RS03770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MPE_RS03775	COG3384	dioxygenase
MPE_RS03805	COG2197	response regulator
MPE_RS03810	COG1335	isochorismatase
MPE_RS03815	COG3845	ABC transporter
MPE_RS03820	COG1335	isochorismatase
MPE_RS03870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPE_RS03875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPE_RS03890	COG2351	hydroxyisourate hydrolase activity
MPE_RS03900	COG2233	PERMEase
MPE_RS03910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MPE_RS03940	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
MPE_RS03960	COG3052	prosthetic group binding
MPE_RS03975	COG1301	dicarboxylic acid transport
MPE_RS03990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MPE_RS03995	COG0583	DNA-binding transcription factor activity
MPE_RS04000	COG0402	S-adenosylhomocysteine deaminase activity
MPE_RS04010	COG3845	ABC transporter
MPE_RS04015	COG4603	Belongs to the binding-protein-dependent transport system permease family
MPE_RS04040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MPE_RS04045	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MPE_RS04050	COG4566	intracellular signal transduction
MPE_RS04100	COG0840	transmembrane signaling receptor activity
MPE_RS04120	COG1131	(ABC) transporter
MPE_RS04125	COG0842	Transport permease protein
MPE_RS04135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MPE_RS04140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MPE_RS04145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MPE_RS04150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MPE_RS04155	COG0131	Imidazoleglycerol-phosphate dehydratase
MPE_RS04165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MPE_RS04170	COG0107	imidazoleglycerol-phosphate synthase activity
MPE_RS04175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MPE_RS04180	COG0140	phosphoribosyl-ATP diphosphatase activity
MPE_RS04190	COG0537	adenosine 5'-monophosphoramidase activity
MPE_RS04195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MPE_RS04200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MPE_RS04205	COG0805	protein transport
MPE_RS04210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPE_RS04215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MPE_RS04220	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MPE_RS04230	COG1970	mechanosensitive ion channel activity
MPE_RS04235	COG0723	plastoquinol--plastocyanin reductase activity
MPE_RS04240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MPE_RS04245	COG2857	Cytochrome c1
MPE_RS04250	COG0625	glutathione transferase activity
MPE_RS04255	COG2969	positive regulation of protein catabolic process
MPE_RS04265	COG3039	Transposase
MPE_RS04280	COG3302	dmso reductase anchor subunit
MPE_RS04285	COG0437	4 iron, 4 sulfur cluster binding
MPE_RS04290	COG0243	molybdopterin cofactor binding
MPE_RS04295	COG0583	DNA-binding transcription factor activity
MPE_RS04320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MPE_RS04350	COG2814	Major facilitator Superfamily
MPE_RS04355	COG1522	sequence-specific DNA binding
MPE_RS04370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MPE_RS04385	COG0183	Belongs to the thiolase family
MPE_RS04390	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPE_RS04445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPE_RS04455	COG1024	Enoyl-CoA hydratase
MPE_RS04460	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS04465	COG2072	flavoprotein involved in K transport
MPE_RS04470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MPE_RS04475	COG2909	trisaccharide binding
MPE_RS04480	COG2072	flavoprotein involved in K transport
MPE_RS04485	COG0604	alcohol dehydrogenase
MPE_RS04490	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPE_RS04495	COG0604	alcohol dehydrogenase
MPE_RS04505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPE_RS04505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPE_RS04505	COG1703	isobutyryl-CoA mutase activity
MPE_RS04520	COG0625	glutathione transferase activity
MPE_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS04530	COG3347	Dehydrogenase
MPE_RS04555	COG1309	transcriptional regulator
MPE_RS04560	COG3852	Histidine kinase
MPE_RS04565	COG2204	response regulator
MPE_RS04580	COG0659	secondary active sulfate transmembrane transporter activity
MPE_RS04615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MPE_RS04620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPE_RS04650	COG2226	methyltransferase
MPE_RS04660	COG0346	lactoylglutathione lyase activity
MPE_RS04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPE_RS04675	COG1063	alcohol dehydrogenase
MPE_RS04715	COG4447	cellulose binding
MPE_RS04745	COG3350	monooxygenase activity
MPE_RS04765	COG0459	protein refolding
MPE_RS04770	COG1914	H( )-stimulated, divalent metal cation uptake system
MPE_RS04790	COG0277	FAD linked oxidase domain protein
MPE_RS04795	COG0277	FAD linked oxidase domain protein
MPE_RS04800	COG0247	lactate metabolic process
MPE_RS04835	COG1609	Transcriptional regulator
MPE_RS04845	COG4948	Mandelate Racemase Muconate Lactonizing
MPE_RS04850	COG2186	Transcriptional regulator
MPE_RS04855	COG3181	Tripartite tricarboxylate transporter family receptor
MPE_RS04860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPE_RS04870	COG2084	Dehydrogenase
MPE_RS04880	COG0842	Transport permease protein
MPE_RS04885	COG1131	(ABC) transporter
MPE_RS04905	COG0154	amidase activity
MPE_RS04915	COG1024	Enoyl-CoA hydratase
MPE_RS04920	COG2050	protein possibly involved in aromatic compounds catabolism
MPE_RS04930	COG3396	Phenylacetate-CoA oxygenase
MPE_RS04935	COG3460	Phenylacetate-CoA oxygenase
MPE_RS04940	COG3396	Phenylacetate-CoA oxygenase
MPE_RS04945	COG2151	metal-sulfur cluster biosynthetic enzyme
MPE_RS04950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MPE_RS04955	COG1309	transcriptional regulator
MPE_RS04960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPE_RS04970	COG2814	Major facilitator Superfamily
MPE_RS04980	COG0387	Pfam Sodium calcium exchanger
MPE_RS04985	COG5001	Diguanylate cyclase
MPE_RS04985	COG2203	Gaf domain
MPE_RS04985	COG4251	negative regulation of phosphorylation
MPE_RS04985	COG3706	GGDEF domain
MPE_RS05050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MPE_RS05050	COG0045	succinate-CoA ligase (ADP-forming) activity
MPE_RS05050	COG1042	CoA-binding domain protein
MPE_RS05060	COG1802	Transcriptional regulator
MPE_RS05065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPE_RS05065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPE_RS05075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPE_RS05080	COG4770	biotin carboxylase activity
MPE_RS05090	COG3706	GGDEF domain
MPE_RS05100	COG1132	(ABC) transporter
MPE_RS05105	COG0189	ligase activity
MPE_RS05105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MPE_RS05110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MPE_RS05110	COG1181	Belongs to the D-alanine--D-alanine ligase family
MPE_RS05115	COG2879	small protein
MPE_RS05120	COG1966	Carbon starvation protein
MPE_RS05145	COG0579	oxidoreductase
MPE_RS05150	COG3409	Peptidoglycan-binding domain 1 protein
MPE_RS05150	COG3267	Type II secretory pathway component ExeA
MPE_RS05175	COG0235	Class ii aldolase
MPE_RS05185	COG2072	flavoprotein involved in K transport
MPE_RS05190	COG1451	nucleotide metabolic process
MPE_RS05205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MPE_RS05220	COG1309	transcriptional regulator
MPE_RS05225	COG1968	undecaprenyl-diphosphatase activity
MPE_RS05255	COG0438	transferase activity, transferring glycosyl groups
MPE_RS05265	COG3039	Transposase
MPE_RS05330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MPE_RS05340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MPE_RS05355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MPE_RS05360	COG0494	nUDIX hydrolase
MPE_RS05370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MPE_RS05375	COG0302	gtp cyclohydrolase
MPE_RS05385	COG4772	TonB-dependent receptor
MPE_RS05415	COG0010	Belongs to the arginase family
MPE_RS05425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MPE_RS05430	COG0793	Belongs to the peptidase S41A family
MPE_RS05435	COG3842	ATPase activity
MPE_RS05440	COG1178	ABC-type Fe3 transport system permease component
MPE_RS05445	COG0582	viral genome integration into host DNA
MPE_RS05460	COG0729	surface antigen
MPE_RS05480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPE_RS05505	COG2860	membrane
MPE_RS05515	COG1024	Enoyl-CoA hydratase
MPE_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS05535	COG0228	four-way junction DNA binding
MPE_RS05540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MPE_RS05545	COG0336	Belongs to the RNA methyltransferase TrmD family
MPE_RS05550	COG0335	large ribosomal subunit rRNA binding
MPE_RS05555	COG0494	nUDIX hydrolase
MPE_RS05570	COG0165	Argininosuccinate lyase
MPE_RS05575	COG0745	RESPONSE REGULATOR receiver
MPE_RS05575	COG2972	Histidine kinase
MPE_RS05585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MPE_RS05585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MPE_RS05595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MPE_RS05600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MPE_RS05605	COG0492	ferredoxin-NADP+ reductase activity
MPE_RS05615	COG1674	ftsk spoiiie
MPE_RS05620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MPE_RS05625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MPE_RS05660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPE_RS05690	COG0425	Belongs to the sulfur carrier protein TusA family
MPE_RS05695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MPE_RS05705	COG0525	valine-tRNA ligase activity
MPE_RS05725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MPE_RS05730	COG0210	DNA helicase
MPE_RS05750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MPE_RS05770	COG2205	protein histidine kinase activity
MPE_RS05770	COG0784	Response regulator, receiver
MPE_RS05775	COG2197	response regulator
MPE_RS05785	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MPE_RS05795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MPE_RS05800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MPE_RS05820	COG0659	secondary active sulfate transmembrane transporter activity
MPE_RS05825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPE_RS05825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPE_RS05830	COG2199	diguanylate cyclase activity
MPE_RS05830	COG2200	EAL domain
MPE_RS05830	COG2203	Gaf domain
MPE_RS05835	COG0489	protein tyrosine kinase activity
MPE_RS05860	COG4191	Histidine kinase
MPE_RS05875	COG3383	formate dehydrogenase (NAD+) activity
MPE_RS05875	COG0243	molybdopterin cofactor binding
MPE_RS05880	COG0437	4 iron, 4 sulfur cluster binding
MPE_RS05905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MPE_RS05910	COG0717	Belongs to the dCTP deaminase family
MPE_RS05945	COG1674	ftsk spoiiie
MPE_RS05990	COG1475	DNA binding
MPE_RS06045	COG0717	Belongs to the dCTP deaminase family
MPE_RS06055	COG2321	neutral zinc metallopeptidase
MPE_RS06065	COG3088	subunit of a heme lyase
MPE_RS06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPE_RS06080	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MPE_RS06095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MPE_RS06100	COG4133	protoheme IX ABC transporter activity
MPE_RS06130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPE_RS06170	COG0811	peptide transport
MPE_RS06200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MPE_RS06210	COG1610	YqeY-like protein
MPE_RS06215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MPE_RS06220	COG2081	HI0933 family
MPE_RS06225	COG0583	DNA-binding transcription factor activity
MPE_RS06230	COG0604	alcohol dehydrogenase
MPE_RS06240	COG2951	lytic endotransglycosylase activity
MPE_RS06255	COG0714	Associated with various cellular activities
MPE_RS06265	COG1196	nuclear chromosome segregation
MPE_RS06265	COG3264	Mechanosensitive ion channel
MPE_RS06270	COG4585	Histidine kinase
MPE_RS06285	COG0604	alcohol dehydrogenase
MPE_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS06285	COG3321	synthase
MPE_RS06290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MPE_RS06295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MPE_RS06310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MPE_RS06320	COG3193	protein, possibly involved in utilization of glycolate and propanediol
MPE_RS06340	COG0505	Belongs to the CarA family
MPE_RS06345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MPE_RS06350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MPE_RS06365	COG1534	Rna-binding protein
MPE_RS06370	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MPE_RS06375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPE_RS06385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPE_RS06390	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MPE_RS06395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MPE_RS06400	COG0573	inorganic phosphate transmembrane transporter activity
MPE_RS06405	COG0581	inorganic phosphate transmembrane transporter activity
MPE_RS06410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MPE_RS06420	COG0745	RESPONSE REGULATOR receiver
MPE_RS06430	COG0534	Mate efflux family protein
MPE_RS06440	COG0254	rRNA binding
MPE_RS06445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MPE_RS06460	COG1074	ATP-dependent DNA helicase activity
MPE_RS06465	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MPE_RS06495	COG0544	peptidyl-prolyl cis-trans isomerase activity
MPE_RS06500	COG0740	serine-type endopeptidase activity
MPE_RS06505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MPE_RS06510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MPE_RS06525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MPE_RS06540	COG1960	acyl-CoA dehydrogenase activity
MPE_RS06550	COG0545	Peptidyl-prolyl cis-trans isomerase
MPE_RS06565	COG1280	lysine exporter protein (LysE YggA)
MPE_RS06575	COG3360	Dodecin
MPE_RS06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPE_RS06665	COG0726	polysaccharide deacetylase
MPE_RS06670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MPE_RS06705	COG0251	oxidation-reduction process
MPE_RS06715	COG2226	methyltransferase
MPE_RS06720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPE_RS06730	COG0433	COG0433 Predicted ATPase
MPE_RS06735	COG0217	transcriptional regulatory protein
MPE_RS06740	COG0151	Belongs to the GarS family
MPE_RS06745	COG0408	coproporphyrinogen oxidase activity
MPE_RS06750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MPE_RS06755	COG0799	negative regulation of ribosome biogenesis
MPE_RS06760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MPE_RS06765	COG0424	maF-like protein
MPE_RS06770	COG1530	ribonuclease E activity
MPE_RS06775	COG0823	Involved in the tonB-independent uptake of proteins
MPE_RS06790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MPE_RS06810	COG2072	flavoprotein involved in K transport
MPE_RS06830	COG2832	Protein of unknown function (DUF454)
MPE_RS06840	COG1393	Belongs to the ArsC family
MPE_RS06845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MPE_RS06850	COG1793	dna ligase
MPE_RS06855	COG2925	Exonuclease
MPE_RS06895	COG2354	Protein conserved in bacteria
MPE_RS06900	COG2916	Histone family protein nucleoid-structuring protein H-NS
MPE_RS06905	COG1840	ABC-type Fe3 transport system, periplasmic component
MPE_RS06910	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MPE_RS06915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MPE_RS06915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MPE_RS06920	COG1643	Atp-dependent helicase
MPE_RS06935	COG2205	protein histidine kinase activity
MPE_RS06935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPE_RS06950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MPE_RS06955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MPE_RS06980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPE_RS06985	COG4654	Cytochrome c, class I
MPE_RS06995	COG0129	dihydroxy-acid dehydratase activity
MPE_RS07000	COG0583	DNA-binding transcription factor activity
MPE_RS07005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MPE_RS07010	COG1116	anion transmembrane transporter activity
MPE_RS07015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPE_RS07020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPE_RS07025	COG3707	response regulator
MPE_RS07035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MPE_RS07040	COG0071	Belongs to the small heat shock protein (HSP20) family
MPE_RS07045	COG0436	Aminotransferase
MPE_RS07050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MPE_RS07055	COG1185	polyribonucleotide nucleotidyltransferase activity
MPE_RS07060	COG0604	alcohol dehydrogenase
MPE_RS07060	COG3321	synthase
MPE_RS07060	COG4221	oxidoreductase activity
MPE_RS07060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MPE_RS07065	COG0149	triose-phosphate isomerase activity
MPE_RS07080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPE_RS07085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPE_RS07090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPE_RS07095	COG0649	NAD binding
MPE_RS07100	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MPE_RS07105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MPE_RS07110	COG1034	ATP synthesis coupled electron transport
MPE_RS07115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MPE_RS07120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPE_RS07130	COG0713	ATP synthesis coupled electron transport
MPE_RS07145	COG1007	ATP synthesis coupled electron transport
MPE_RS07155	COG0494	nUDIX hydrolase
MPE_RS07165	COG0277	FAD linked oxidase domain protein
MPE_RS07175	COG1295	ribonuclease BN
MPE_RS07190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MPE_RS07205	COG0312	modulator of DNA gyrase
MPE_RS07210	COG1760	l-serine dehydratase
MPE_RS07220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPE_RS07220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPE_RS07225	COG0509	glycine decarboxylation via glycine cleavage system
MPE_RS07230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MPE_RS07240	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS07245	COG1024	Enoyl-CoA hydratase
MPE_RS07250	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MPE_RS07270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MPE_RS07275	COG2130	NADP-dependent
MPE_RS07305	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS07310	COG3132	Protein of unknown function, DUF480
MPE_RS07330	COG0297	glycogen (starch) synthase activity
MPE_RS07395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MPE_RS07400	COG0583	DNA-binding transcription factor activity
MPE_RS07405	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MPE_RS07410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MPE_RS07440	COG0446	pyridine nucleotide-disulphide oxidoreductase
MPE_RS07450	COG0583	DNA-binding transcription factor activity
MPE_RS07455	COG1850	ribulose-bisphosphate carboxylase activity
MPE_RS07460	COG4451	ribulose bisphosphate carboxylase, small
MPE_RS07465	COG0464	growth
MPE_RS07470	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MPE_RS07475	COG3954	Phosphoribulokinase
MPE_RS07480	COG0546	phosphoglycolate phosphatase activity
MPE_RS07485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MPE_RS07515	COG3047	cAMP biosynthetic process
MPE_RS07540	COG4774	siderophore transport
MPE_RS07545	COG0492	ferredoxin-NADP+ reductase activity
MPE_RS07550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MPE_RS07560	COG0529	Catalyzes the synthesis of activated sulfate
MPE_RS07560	COG2895	sulfate adenylyltransferase (ATP) activity
MPE_RS07565	COG0175	sulfate reduction
MPE_RS07570	COG0175	sulfate reduction
MPE_RS07585	COG0730	response to heat
MPE_RS07590	COG1752	Esterase of the alpha-beta hydrolase superfamily
MPE_RS07600	COG0123	including yeast histone deacetylase and acetoin utilization protein
MPE_RS07605	COG0824	Thioesterase
MPE_RS07610	COG2423	ornithine cyclodeaminase activity
MPE_RS07625	COG4772	TonB-dependent receptor
MPE_RS07630	COG3038	cytochrome b561
MPE_RS07650	COG1201	RNA secondary structure unwinding
MPE_RS07655	COG1793	dna ligase
MPE_RS07660	COG1793	dna ligase
MPE_RS07660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MPE_RS07665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MPE_RS07690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MPE_RS07695	COG0360	Binds together with S18 to 16S ribosomal RNA
MPE_RS07700	COG2965	DNA replication, synthesis of RNA primer
MPE_RS07705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MPE_RS07710	COG0359	binds to the 23S rRNA
MPE_RS07715	COG0305	Participates in initiation and elongation during chromosome replication
MPE_RS07730	COG0587	DNA-directed DNA polymerase activity
MPE_RS07750	COG0183	Belongs to the thiolase family
MPE_RS07755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MPE_RS07760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MPE_RS07770	COG0436	Aminotransferase
MPE_RS07785	COG1763	Mo-molybdopterin cofactor biosynthetic process
MPE_RS07790	COG0303	'Molybdopterin
MPE_RS07800	COG0515	serine threonine protein kinase
MPE_RS07800	COG2815	serine threonine protein kinase
MPE_RS07805	COG0314	molybdopterin synthase activity
MPE_RS07810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MPE_RS07815	COG0542	response to heat
MPE_RS07825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MPE_RS07840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MPE_RS07855	COG0028	Belongs to the TPP enzyme family
MPE_RS07865	COG0697	spore germination
MPE_RS07870	COG1522	sequence-specific DNA binding
MPE_RS07875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MPE_RS07880	COG0392	lysyltransferase activity
MPE_RS07880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MPE_RS07910	COG0560	Phosphoserine phosphatase
MPE_RS07915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MPE_RS07920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MPE_RS07920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MPE_RS07925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MPE_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS07960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MPE_RS07975	COG0753	catalase activity
MPE_RS07980	COG0431	NADPH-dependent FMN reductase
MPE_RS07985	COG0798	PFAM Bile acid sodium symporter
MPE_RS08005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MPE_RS08060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MPE_RS08065	COG0095	Lipoate-protein ligase
MPE_RS08070	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPE_RS08070	COG0596	Alpha beta hydrolase
MPE_RS08075	COG0022	dehydrogenase e1 component
MPE_RS08080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MPE_RS08085	COG3199	ATP-NAD kinase
MPE_RS08090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MPE_RS08100	COG0351	phosphomethylpyrimidine kinase
MPE_RS08110	COG2104	thiamine diphosphate biosynthetic process
MPE_RS08120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MPE_RS08125	COG3284	Transcriptional regulator
MPE_RS08135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MPE_RS08140	COG0626	cystathionine gamma-synthase activity
MPE_RS08145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MPE_RS08155	COG2914	Belongs to the UPF0125 (RnfH) family
MPE_RS08175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MPE_RS08175	COG0519	Catalyzes the synthesis of GMP from XMP
MPE_RS08180	COG0582	viral genome integration into host DNA
MPE_RS08200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MPE_RS08225	COG2132	Multicopper oxidase
MPE_RS08250	COG0789	Transcriptional regulator
MPE_RS08255	COG2217	Heavy metal translocating P-type atpase
MPE_RS08280	COG2217	Heavy metal translocating P-type atpase
MPE_RS08290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MPE_RS08335	COG1742	UPF0060 membrane protein
MPE_RS08340	COG0789	Transcriptional regulator
MPE_RS08345	COG2003	Belongs to the UPF0758 family
MPE_RS08360	COG3609	addiction module antidote protein, CC2985 family
MPE_RS08365	COG0789	Transcriptional regulator
MPE_RS08375	COG2608	mercury ion transmembrane transporter activity
MPE_RS08380	COG0629	single-stranded DNA binding
MPE_RS08420	COG1204	response to ionizing radiation
MPE_RS08495	COG3850	Histidine kinase
MPE_RS08500	COG3945	hemerythrin HHE cation binding domain
MPE_RS08515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPE_RS08560	COG2151	metal-sulfur cluster biosynthetic enzyme
MPE_RS08575	COG0288	reversible hydration of carbon dioxide
MPE_RS08585	COG2181	nitrate reductase activity
MPE_RS08590	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MPE_RS08595	COG1140	nitrate reductase beta subunit
MPE_RS08600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MPE_RS08605	COG2223	nitrite transmembrane transporter activity
MPE_RS08635	COG0530	calcium, potassium:sodium antiporter activity
MPE_RS08660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MPE_RS08685	COG0670	Belongs to the BI1 family
MPE_RS08710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MPE_RS08750	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MPE_RS08755	COG0642	Histidine kinase
MPE_RS08765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MPE_RS08770	COG1845	cytochrome c oxidase, subunit III
MPE_RS08775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MPE_RS08780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MPE_RS08785	COG0477	Major facilitator Superfamily
MPE_RS08790	COG0667	Aldo Keto reductase
MPE_RS08805	COG1619	proteins homologs of microcin C7 resistance protein MccF
MPE_RS08810	COG0747	negative chemotaxis
MPE_RS08820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPE_RS08830	COG4206	TonB-dependent receptor
MPE_RS08860	COG0024	Methionine aminopeptidase
MPE_RS08865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MPE_RS08865	COG0047	phosphoribosylformylglycinamidine synthase activity
MPE_RS08875	COG0477	Major facilitator Superfamily
MPE_RS08880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MPE_RS08890	COG2917	probably involved in intracellular septation
MPE_RS08895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MPE_RS08900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MPE_RS08935	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPE_RS08935	COG1024	Enoyl-CoA hydratase
MPE_RS08940	COG0183	Belongs to the thiolase family
MPE_RS08945	COG1960	acyl-CoA dehydrogenase activity
MPE_RS08970	COG2130	NADP-dependent
MPE_RS08995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MPE_RS09005	COG0861	Integral membrane protein TerC family
MPE_RS09020	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MPE_RS09025	COG2183	response to ionizing radiation
MPE_RS09030	COG2943	transferase activity, transferring hexosyl groups
MPE_RS09035	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MPE_RS09055	COG1454	alcohol dehydrogenase
MPE_RS09075	COG0488	(ABC) transporter
MPE_RS09080	COG2890	protein-(glutamine-N5) methyltransferase activity
MPE_RS09085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPE_RS09095	COG2171	N-acyltransferase activity
MPE_RS09105	COG1846	Transcriptional regulator
MPE_RS09110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MPE_RS09115	COG1196	nuclear chromosome segregation
MPE_RS09125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPE_RS09130	COG0242	peptide deformylase activity
MPE_RS09145	COG4181	ATPase activity
MPE_RS09150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPE_RS09155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MPE_RS09160	COG2814	Major facilitator Superfamily
MPE_RS09165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MPE_RS09175	COG2366	antibiotic biosynthetic process
MPE_RS09195	COG4181	ATPase activity
MPE_RS09220	COG1294	oxidase, subunit
MPE_RS09225	COG0723	plastoquinol--plastocyanin reductase activity
MPE_RS09350	COG0084	hydrolase, TatD family'
MPE_RS09365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MPE_RS09370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MPE_RS09375	COG0354	folic acid binding
MPE_RS09390	COG0252	asparaginase activity
MPE_RS09395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MPE_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS09410	COG0183	Belongs to the thiolase family
MPE_RS09415	COG3243	poly(R)-hydroxyalkanoic acid synthase
MPE_RS09425	COG0625	glutathione transferase activity
MPE_RS09435	COG2816	NAD+ diphosphatase activity
MPE_RS09440	COG2274	protein secretion by the type I secretion system
MPE_RS09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPE_RS09480	COG0776	regulation of translation
MPE_RS09485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPE_RS09485	COG0072	phenylalanine-tRNA ligase activity
MPE_RS09490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MPE_RS09495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MPE_RS09500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MPE_RS09505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MPE_RS09510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MPE_RS09515	COG2224	Isocitrate lyase
MPE_RS09520	COG0010	Belongs to the arginase family
MPE_RS09550	COG0714	Associated with various cellular activities
MPE_RS09555	COG1522	sequence-specific DNA binding
MPE_RS09560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MPE_RS09565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPE_RS09570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MPE_RS09590	COG3842	ATPase activity
MPE_RS09595	COG1176	ABC-type spermidine putrescine transport system, permease component I
MPE_RS09600	COG1177	transmembrane transport
MPE_RS09615	COG1012	belongs to the aldehyde dehydrogenase family
MPE_RS09620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MPE_RS09635	COG0252	asparaginase activity
MPE_RS09640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MPE_RS09650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MPE_RS09665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MPE_RS09670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MPE_RS09675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MPE_RS09680	COG2251	uridine kinase activity
MPE_RS09680	COG0195	Participates in both transcription termination and antitermination
MPE_RS09685	COG0779	Required for maturation of 30S ribosomal subunits
MPE_RS09730	COG0604	alcohol dehydrogenase
MPE_RS09780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MPE_RS09800	COG0583	DNA-binding transcription factor activity
MPE_RS09805	COG0436	Aminotransferase
MPE_RS09845	COG0625	glutathione transferase activity
MPE_RS09855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MPE_RS09885	COG0322	excinuclease ABC activity
MPE_RS09895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MPE_RS09905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MPE_RS09905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPE_RS09910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPE_RS09915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MPE_RS09920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPE_RS09925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPE_RS09930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MPE_RS09935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPE_RS09945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MPE_RS09950	COG0750	zinc metalloprotease
MPE_RS09955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MPE_RS09960	COG0575	Belongs to the CDS family
MPE_RS09970	COG0233	cytoplasmic translational termination
MPE_RS09975	COG0528	UMP kinase activity
MPE_RS09980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MPE_RS09985	COG0052	Belongs to the universal ribosomal protein uS2 family
MPE_RS10000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MPE_RS10000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MPE_RS10020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MPE_RS10025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MPE_RS10030	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MPE_RS10035	COG0330	HflC and HflK could
MPE_RS10040	COG0330	HflC and HflK could
MPE_RS10045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MPE_RS10050	COG1923	regulation of RNA biosynthetic process
MPE_RS10055	COG1160	GTP binding
MPE_RS10060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MPE_RS10070	COG0124	histidyl-tRNA synthetase
MPE_RS10075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MPE_RS10090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MPE_RS10095	COG0105	UTP biosynthetic process
MPE_RS10100	COG1187	pseudouridine synthase activity
MPE_RS10105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MPE_RS10110	COG0564	pseudouridine synthase activity
MPE_RS10120	COG1199	ATP-dependent helicase activity
MPE_RS10140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MPE_RS10145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MPE_RS10150	COG2076	Multidrug Resistance protein
MPE_RS10155	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPE_RS10160	COG0567	Dehydrogenase, E1 component
MPE_RS10165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MPE_RS10175	COG2833	Protein of unknown function (DUF455)
MPE_RS10185	COG2833	Protein of unknown function (DUF455)
MPE_RS10190	COG2095	MarC family integral membrane protein
MPE_RS10200	COG4974	Belongs to the 'phage' integrase family
MPE_RS10215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MPE_RS10220	COG0802	atpase or kinase
MPE_RS10225	COG0860	N-Acetylmuramoyl-L-alanine amidase
MPE_RS10230	COG1278	Cold shock
MPE_RS10235	COG0586	Pfam SNARE associated Golgi protein
MPE_RS10240	COG4651	solute:proton antiporter activity
MPE_RS10240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MPE_RS10245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MPE_RS10250	COG2267	carboxylic ester hydrolase activity
MPE_RS10255	COG1187	pseudouridine synthase activity
MPE_RS10260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MPE_RS10295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS10300	COG0071	Belongs to the small heat shock protein (HSP20) family
MPE_RS10305	COG0071	Belongs to the small heat shock protein (HSP20) family
MPE_RS10310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MPE_RS10315	COG1183	phosphatidylcholine synthase activity
MPE_RS10320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MPE_RS10335	COG1132	(ABC) transporter
MPE_RS10345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MPE_RS10365	COG3046	protein related to deoxyribodipyrimidine photolyase
MPE_RS10380	COG0071	Belongs to the small heat shock protein (HSP20) family
MPE_RS10390	COG3243	poly(R)-hydroxyalkanoic acid synthase
MPE_RS10395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPE_RS10400	COG1063	alcohol dehydrogenase
MPE_RS10420	COG1136	(ABC) transporter
MPE_RS10455	COG3852	Histidine kinase
MPE_RS10465	COG0174	glutamine synthetase
MPE_RS10495	COG1940	carbohydrate kinase activity
MPE_RS10505	COG0488	(ABC) transporter
MPE_RS10525	COG0513	Belongs to the DEAD box helicase family
MPE_RS10545	COG3022	response to hydroperoxide
MPE_RS10550	COG3012	SEC-C Motif Domain Protein
MPE_RS10555	COG3634	alkyl hydroperoxide reductase activity
MPE_RS10570	COG0247	lactate metabolic process
MPE_RS10575	COG1592	Rubrerythrin
MPE_RS10580	COG1414	Transcriptional regulator
MPE_RS10590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPE_RS10595	COG1183	phosphatidylcholine synthase activity
MPE_RS10600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MPE_RS10605	COG0440	acetolactate synthase activity
MPE_RS10610	COG0028	Belongs to the TPP enzyme family
MPE_RS10635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MPE_RS10645	COG0347	Belongs to the P(II) protein family
MPE_RS10650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MPE_RS10650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPE_RS10660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MPE_RS10665	COG1522	sequence-specific DNA binding
MPE_RS10680	COG0612	Peptidase, M16
MPE_RS10685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MPE_RS10695	COG0583	DNA-binding transcription factor activity
MPE_RS10715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MPE_RS10720	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPE_RS10725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MPE_RS10730	COG4191	Histidine kinase
MPE_RS10735	COG4566	intracellular signal transduction
MPE_RS10740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MPE_RS10755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MPE_RS10775	COG0167	dihydroorotate dehydrogenase activity
MPE_RS10810	COG2130	NADP-dependent
MPE_RS10845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPE_RS10870	COG0285	dihydrofolate synthase activity
MPE_RS10875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MPE_RS10880	COG0159	tryptophan synthase activity
MPE_RS10885	COG0133	tryptophan synthase activity
MPE_RS10890	COG0135	phosphoribosylanthranilate isomerase activity
MPE_RS10895	COG0101	tRNA pseudouridine synthase activity
MPE_RS10905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MPE_RS10910	COG0473	3-isopropylmalate dehydrogenase activity
MPE_RS10915	COG0066	3-isopropylmalate dehydratase activity
MPE_RS10920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MPE_RS10925	COG0372	Belongs to the citrate synthase family
MPE_RS10930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MPE_RS10935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MPE_RS10940	COG1053	succinate dehydrogenase
MPE_RS10945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MPE_RS10955	COG2188	Transcriptional regulator
MPE_RS10960	COG0039	L-malate dehydrogenase activity
MPE_RS10985	COG0513	Belongs to the DEAD box helicase family
MPE_RS11005	COG0671	phosphoesterase, PA-phosphatase related
MPE_RS11015	COG1597	lipid kinase activity
MPE_RS11025	COG1132	(ABC) transporter
MPE_RS11050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPE_RS11075	COG0564	pseudouridine synthase activity
MPE_RS11095	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MPE_RS11105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPE_RS11110	COG1278	Cold shock
MPE_RS11115	COG0443	Heat shock 70 kDa protein
MPE_RS11140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MPE_RS11145	COG1620	l-lactate permease
MPE_RS11170	COG2199	diguanylate cyclase activity
MPE_RS11170	COG2200	EAL domain
MPE_RS11180	COG1252	NADH dehydrogenase
MPE_RS11210	COG1126	abc transporter atp-binding protein
MPE_RS11230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MPE_RS11250	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS11280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MPE_RS11300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MPE_RS11310	COG0287	Prephenate dehydrogenase
MPE_RS11315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MPE_RS11335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MPE_RS11340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MPE_RS11370	COG1346	cytolysis
MPE_RS11375	COG1380	Effector of murein hydrolase LrgA
MPE_RS11385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MPE_RS11395	COG0443	Heat shock 70 kDa protein
MPE_RS11400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MPE_RS11410	COG0822	iron-sulfur transferase activity
MPE_RS11415	COG1104	cysteine desulfurase activity
MPE_RS11420	COG1959	2 iron, 2 sulfur cluster binding
MPE_RS11425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MPE_RS11435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPE_RS11440	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MPE_RS11540	COG0556	nucleotide-excision repair
MPE_RS11590	COG2878	Part of a membrane complex involved in electron transport
MPE_RS11595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MPE_RS11620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MPE_RS11625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MPE_RS11630	COG1492	cobalamin metabolic process
MPE_RS11635	COG1120	ATPase activity
MPE_RS11640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPE_RS11655	COG4774	siderophore transport
MPE_RS11675	COG0730	response to heat
MPE_RS11685	COG3707	response regulator
MPE_RS11690	COG2223	nitrite transmembrane transporter activity
MPE_RS11695	COG2815	serine threonine protein kinase
MPE_RS11695	COG0515	serine threonine protein kinase
MPE_RS11700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MPE_RS11705	COG2146	nitrite reductase [NAD(P)H] activity
MPE_RS11710	COG0243	molybdopterin cofactor binding
MPE_RS11715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MPE_RS11730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MPE_RS11750	COG0583	DNA-binding transcription factor activity
MPE_RS11755	COG0583	DNA-binding transcription factor activity
MPE_RS11820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MPE_RS11830	COG0798	PFAM Bile acid sodium symporter
MPE_RS11845	COG0640	Transcriptional regulator
MPE_RS12080	COG2003	Belongs to the UPF0758 family
MPE_RS12140	COG0582	viral genome integration into host DNA
MPE_RS12160	COG0583	DNA-binding transcription factor activity
MPE_RS12175	COG0531	amino acid
MPE_RS12180	COG4303	Ethanolamine ammonia lyase large subunit
MPE_RS12245	COG0446	pyridine nucleotide-disulphide oxidoreductase
MPE_RS12260	COG0737	Belongs to the 5'-nucleotidase family
MPE_RS12285	COG4654	Cytochrome c, class I
MPE_RS12290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MPE_RS12300	COG2391	methyltransferase activity
MPE_RS12305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS12310	COG2267	carboxylic ester hydrolase activity
MPE_RS12315	COG0657	acetylesterase activity
MPE_RS12320	COG3039	Transposase
MPE_RS12330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS12350	COG3437	response regulator, receiver
MPE_RS12355	COG2204	response regulator
MPE_RS12370	COG0037	tRNA processing
MPE_RS12375	COG0825	malonyl-CoA metabolic process
MPE_RS12385	COG0215	cysteine-tRNA ligase activity
MPE_RS12400	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPE_RS12405	COG3228	Belongs to the MtfA family
MPE_RS12410	COG0542	response to heat
MPE_RS12415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MPE_RS12420	COG1278	Cold shock
MPE_RS12455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MPE_RS12460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPE_RS12495	COG3278	Belongs to the heme-copper respiratory oxidase family
MPE_RS12505	COG2217	Heavy metal translocating P-type atpase
MPE_RS12515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MPE_RS12520	COG1570	exodeoxyribonuclease VII activity
MPE_RS12525	COG0811	peptide transport
MPE_RS12530	COG0848	biopolymer transport protein
MPE_RS12535	COG1663	tetraacyldisaccharide 4'-kinase activity
MPE_RS12540	COG2835	tetraacyldisaccharide 4'-kinase activity
MPE_RS12545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MPE_RS12550	COG0563	adenylate kinase activity
MPE_RS12575	COG1011	Hydrolase
MPE_RS12585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MPE_RS12590	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MPE_RS12595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MPE_RS12600	COG0443	Heat shock 70 kDa protein
MPE_RS12605	COG0484	heat shock protein binding
MPE_RS12620	COG0745	RESPONSE REGULATOR receiver
MPE_RS12625	COG2205	protein histidine kinase activity
MPE_RS12630	COG0598	Magnesium transport protein CorA
MPE_RS12635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MPE_RS12640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MPE_RS12645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MPE_RS12670	COG1280	lysine exporter protein (LysE YggA)
MPE_RS12695	COG0604	alcohol dehydrogenase
MPE_RS12700	COG1309	transcriptional regulator
MPE_RS12705	COG0791	NLP P60 protein
MPE_RS12710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MPE_RS12715	COG0746	molybdenum cofactor guanylyltransferase activity
MPE_RS12725	COG0303	'Molybdopterin
MPE_RS12735	COG2010	Cytochrome c
MPE_RS12745	COG0328	RNA-DNA hybrid ribonuclease activity
MPE_RS12750	COG2226	methyltransferase
MPE_RS12755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPE_RS12760	COG1388	LysM domain
MPE_RS12760	COG0741	lytic transglycosylase activity
MPE_RS12770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MPE_RS12775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MPE_RS12785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MPE_RS12790	COG4566	intracellular signal transduction
MPE_RS12795	COG4191	Histidine kinase
MPE_RS12800	COG3039	Transposase
MPE_RS12845	COG0840	transmembrane signaling receptor activity
MPE_RS12855	COG2308	Evidence 4 Homologs of previously reported genes of
MPE_RS12885	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MPE_RS12915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MPE_RS12920	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MPE_RS12940	COG2850	peptidyl-arginine hydroxylation
MPE_RS12945	COG1047	Peptidyl-prolyl cis-trans
MPE_RS12950	COG0756	dUTP diphosphatase activity
MPE_RS12955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MPE_RS12965	COG1271	oxidase subunit
MPE_RS12970	COG1294	oxidase, subunit
MPE_RS12975	COG0583	DNA-binding transcription factor activity
MPE_RS13010	COG2414	aldehyde ferredoxin oxidoreductase
MPE_RS13015	COG0493	'glutamate synthase
MPE_RS13015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MPE_RS13020	COG3284	Transcriptional regulator
MPE_RS13030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MPE_RS13045	COG0535	radical SAM domain protein
MPE_RS13050	COG1131	(ABC) transporter
MPE_RS13085	COG3039	Transposase
MPE_RS13095	COG3039	Transposase
MPE_RS13105	COG3039	Transposase
MPE_RS13120	COG2197	response regulator
MPE_RS13140	COG0702	epimerase
MPE_RS13150	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MPE_RS13155	COG0189	ligase activity
MPE_RS13165	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MPE_RS13175	COG3284	Transcriptional regulator
MPE_RS13225	COG1229	Formylmethanofuran dehydrogenase subunit A
MPE_RS13230	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MPE_RS13245	COG0512	Glutamine amidotransferase of anthranilate synthase
MPE_RS13245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MPE_RS13255	COG1469	GTP cyclohydrolase I activity
MPE_RS13260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MPE_RS13265	COG0142	geranyltranstransferase activity
MPE_RS13270	COG1722	exodeoxyribonuclease VII activity
MPE_RS13290	COG0589	response to stress
MPE_RS13295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MPE_RS13315	COG0642	Histidine kinase
MPE_RS13375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPE_RS13385	COG3391	amine dehydrogenase activity
MPE_RS13405	COG1024	Enoyl-CoA hydratase
MPE_RS13410	COG3246	L-lysine catabolic process to acetate
MPE_RS13420	COG2226	methyltransferase
MPE_RS13430	COG0840	transmembrane signaling receptor activity
MPE_RS13455	COG1022	Amp-dependent synthetase and ligase
MPE_RS13495	COG1960	acyl-CoA dehydrogenase activity
MPE_RS13505	COG1414	Transcriptional regulator
MPE_RS13520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MPE_RS13525	COG0789	Transcriptional regulator
MPE_RS13535	COG0655	NAD(P)H dehydrogenase (quinone) activity
MPE_RS13550	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS13565	COG1335	isochorismatase
MPE_RS13580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MPE_RS13585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MPE_RS13590	COG1047	Peptidyl-prolyl cis-trans
MPE_RS13595	COG2003	Belongs to the UPF0758 family
MPE_RS13615	COG3706	GGDEF domain
MPE_RS13620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MPE_RS13625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MPE_RS13630	COG2201	protein-glutamate methylesterase activity
MPE_RS13635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MPE_RS13640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MPE_RS13645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MPE_RS13660	COG1561	YicC-like family, N-terminal region
MPE_RS13665	COG0582	viral genome integration into host DNA
MPE_RS13675	COG1396	sequence-specific DNA binding
MPE_RS13700	COG0194	GDP metabolic process
MPE_RS13705	COG1758	RNA polymerase activity
MPE_RS13715	COG2391	methyltransferase activity
MPE_RS13720	COG0640	Transcriptional regulator
MPE_RS13730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MPE_RS13735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPE_RS13745	COG0367	asparagine synthase
MPE_RS13775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MPE_RS13780	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MPE_RS13785	COG0489	protein tyrosine kinase activity
MPE_RS13800	COG2226	methyltransferase
MPE_RS13820	COG0584	glycerophosphoryl diester phosphodiesterase
MPE_RS13835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MPE_RS13840	COG0653	protein targeting
MPE_RS13845	COG0739	heme binding
MPE_RS13855	COG1136	(ABC) transporter
MPE_RS13880	COG2133	pyrroloquinoline quinone binding
MPE_RS13885	COG2133	pyrroloquinoline quinone binding
MPE_RS13890	COG0745	RESPONSE REGULATOR receiver
MPE_RS13895	COG0642	Histidine kinase
MPE_RS13900	COG0613	PHP domain protein
MPE_RS13905	COG0009	L-threonylcarbamoyladenylate synthase
MPE_RS13915	COG0251	oxidation-reduction process
MPE_RS13920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MPE_RS13925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MPE_RS13935	COG1132	(ABC) transporter
MPE_RS13950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MPE_RS13985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MPE_RS13990	COG0308	aminopeptidase N
MPE_RS13995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MPE_RS14000	COG0205	6-phosphofructokinase activity
MPE_RS14020	COG0644	oxidoreductase
MPE_RS14025	COG0840	transmembrane signaling receptor activity
MPE_RS14035	COG1850	ribulose-bisphosphate carboxylase activity
MPE_RS14045	COG0464	growth
MPE_RS14055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MPE_RS14060	COG0546	phosphoglycolate phosphatase activity
MPE_RS14065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MPE_RS14070	COG3954	Phosphoribulokinase
MPE_RS14075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MPE_RS14080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MPE_RS14085	COG0126	phosphoglycerate kinase activity
MPE_RS14090	COG0191	fructose-bisphosphate aldolase activity
MPE_RS14095	COG3045	CreA protein
MPE_RS14105	COG0688	phosphatidylethanolamine metabolic process
MPE_RS14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPE_RS14110	COG4191	Histidine kinase
MPE_RS14120	COG1122	ATPase activity
MPE_RS14145	COG4771	TonB-dependent receptor
MPE_RS14165	COG2204	response regulator
MPE_RS14170	COG1024	Enoyl-CoA hydratase
MPE_RS14170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MPE_RS14180	COG0309	Hydrogenase expression formation protein (HypE)
MPE_RS14185	COG0409	Hydrogenase expression formation protein
MPE_RS14190	COG0298	carbon dioxide binding
MPE_RS14195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MPE_RS14200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPE_RS14205	COG0375	protein maturation
MPE_RS14210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MPE_RS14215	COG1773	rubredoxin
MPE_RS14220	COG1773	rubredoxin
MPE_RS14225	COG1773	rubredoxin
MPE_RS14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPE_RS14235	COG0298	carbon dioxide binding
MPE_RS14240	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MPE_RS14245	COG3093	addiction module antidote protein HigA
MPE_RS14250	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
MPE_RS14265	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MPE_RS14280	COG3220	belongs to the UPF0276 family
MPE_RS14300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MPE_RS14305	COG0312	modulator of DNA gyrase
MPE_RS14315	COG0521	Mo-molybdopterin cofactor biosynthetic process
MPE_RS14320	COG1045	serine acetyltransferase
MPE_RS14330	COG0483	inositol monophosphate 1-phosphatase activity
MPE_RS14335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MPE_RS14350	COG0504	CTP synthase activity
MPE_RS14355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MPE_RS14360	COG0148	phosphopyruvate hydratase activity
MPE_RS14365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MPE_RS14380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MPE_RS14390	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS14395	COG1253	flavin adenine dinucleotide binding
MPE_RS14400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MPE_RS14425	COG2205	protein histidine kinase activity
MPE_RS14425	COG0784	Response regulator, receiver
MPE_RS14425	COG5002	protein histidine kinase activity
MPE_RS14445	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MPE_RS14460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MPE_RS14470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MPE_RS14495	COG1360	Flagellar Motor Protein
MPE_RS14505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MPE_RS14515	COG1054	Belongs to the UPF0176 family
MPE_RS14525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPE_RS14530	COG4215	(ABC) transporter
MPE_RS14535	COG4160	amino acid transport
MPE_RS14565	COG0431	NADPH-dependent FMN reductase
MPE_RS14575	COG1741	Belongs to the pirin family
MPE_RS14580	COG0583	DNA-binding transcription factor activity
MPE_RS14630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPE_RS14640	COG2197	response regulator
MPE_RS14645	COG4585	Histidine kinase
MPE_RS14685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MPE_RS14690	COG0501	Belongs to the peptidase M48B family
MPE_RS14695	COG2154	pterin-4-alpha-carbinolamine dehydratase
MPE_RS14700	COG1162	GTPase activity
MPE_RS14705	COG2072	flavoprotein involved in K transport
MPE_RS14710	COG2909	trisaccharide binding
MPE_RS14720	COG0513	Belongs to the DEAD box helicase family
MPE_RS14730	COG0840	transmembrane signaling receptor activity
MPE_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS14755	COG0346	lactoylglutathione lyase activity
MPE_RS14765	COG0628	permease
MPE_RS14770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MPE_RS14785	COG0259	pyridoxamine-phosphate oxidase activity
MPE_RS14800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MPE_RS14810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MPE_RS14815	COG0741	lytic transglycosylase activity
MPE_RS14820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MPE_RS14825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MPE_RS14855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MPE_RS14855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MPE_RS14870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MPE_RS14875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MPE_RS14880	COG0436	Aminotransferase
MPE_RS14895	COG0824	Thioesterase
MPE_RS14925	COG3220	belongs to the UPF0276 family
MPE_RS14935	COG1595	DNA-templated transcription, initiation
MPE_RS14955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MPE_RS14960	COG3039	Transposase
MPE_RS14965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MPE_RS14980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MPE_RS14990	COG0515	serine threonine protein kinase
MPE_RS14990	COG2815	serine threonine protein kinase
MPE_RS14995	COG2084	Dehydrogenase
MPE_RS15070	COG3039	Transposase
MPE_RS15080	COG3039	Transposase
MPE_RS15090	COG3039	Transposase
MPE_RS15105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MPE_RS15135	COG2959	enzyme of heme biosynthesis
MPE_RS15145	COG0181	hydroxymethylbilane synthase activity
MPE_RS15150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MPE_RS15160	COG0412	Dienelactone hydrolase
MPE_RS15165	COG0248	Ppx GppA phosphatase
MPE_RS15175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MPE_RS15190	COG0297	glycogen (starch) synthase activity
MPE_RS15210	COG0306	phosphate transporter
MPE_RS15220	COG1428	Deoxynucleoside kinase
MPE_RS15235	COG0617	tRNA 3'-terminal CCA addition
MPE_RS15250	COG0628	permease
MPE_RS15265	COG0728	peptidoglycan biosynthetic process
MPE_RS15270	COG0268	Binds directly to 16S ribosomal RNA
MPE_RS15280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MPE_RS15285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MPE_RS15295	COG2815	serine threonine protein kinase
MPE_RS15295	COG0515	serine threonine protein kinase
MPE_RS15300	COG3781	membrane
MPE_RS15310	COG0137	argininosuccinate synthase activity
MPE_RS15325	COG2154	pterin-4-alpha-carbinolamine dehydratase
MPE_RS15330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MPE_RS15335	COG1666	GTP binding
MPE_RS15355	COG2197	response regulator
MPE_RS15365	COG0196	riboflavin kinase activity
MPE_RS15375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MPE_RS15395	COG0697	spore germination
MPE_RS15400	COG5001	Diguanylate cyclase
MPE_RS15400	COG3300	MHYT domain
MPE_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS15410	COG0697	spore germination
MPE_RS15430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MPE_RS15445	COG0084	hydrolase, TatD family'
MPE_RS15460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MPE_RS15475	COG1706	bacterial-type flagellum-dependent cell motility
MPE_RS15480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MPE_RS15485	COG4786	Flagellar basal body rod
MPE_RS15490	COG4787	bacterial-type flagellum-dependent cell motility
MPE_RS15495	COG1749	Flagellar hook protein flgE
MPE_RS15500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MPE_RS15505	COG1558	bacterial-type flagellum-dependent cell motility
MPE_RS15510	COG1815	bacterial-type flagellum-dependent cell motility
MPE_RS15535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MPE_RS15550	COG1191	sigma factor activity
MPE_RS15590	COG0004	ammonium transporteR
MPE_RS15595	COG0243	molybdopterin cofactor binding
MPE_RS15605	COG1473	amidohydrolase
MPE_RS15615	COG0166	Belongs to the GPI family
MPE_RS15620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MPE_RS15635	COG2853	Lipoprotein
MPE_RS15640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPE_RS15645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPE_RS15650	COG1127	ABC transporter
MPE_RS15660	COG0070	glutamate synthase
MPE_RS15660	COG0069	glutamate synthase activity
MPE_RS15660	COG0067	glutamate synthase
MPE_RS15675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MPE_RS15680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MPE_RS15685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MPE_RS15720	COG1965	Belongs to the frataxin family
MPE_RS15730	COG4608	Belongs to the ABC transporter superfamily
MPE_RS15735	COG0444	Belongs to the ABC transporter superfamily
MPE_RS15755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MPE_RS15760	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MPE_RS15770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MPE_RS15775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MPE_RS15795	COG2165	general secretion pathway protein
MPE_RS15800	COG4795	General secretion pathway protein
MPE_RS15845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MPE_RS15870	COG1490	D-aminoacyl-tRNA deacylase activity
MPE_RS15875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MPE_RS15895	COG0642	Histidine kinase
MPE_RS15900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MPE_RS15910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MPE_RS15915	COG0316	Belongs to the HesB IscA family
MPE_RS15930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MPE_RS15935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MPE_RS15950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MPE_RS15955	COG0326	Molecular chaperone. Has ATPase activity
MPE_RS15965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MPE_RS15980	COG0012	GTP binding
MPE_RS15985	COG5002	protein histidine kinase activity
MPE_RS15985	COG2198	Histidine kinase
MPE_RS15985	COG0784	Response regulator, receiver
MPE_RS15990	COG0642	Histidine kinase
MPE_RS15995	COG0745	RESPONSE REGULATOR receiver
MPE_RS16000	COG1960	acyl-CoA dehydrogenase activity
MPE_RS16005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MPE_RS16010	COG1999	signal sequence binding
MPE_RS16015	COG0109	protoheme IX farnesyltransferase activity
MPE_RS16050	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MPE_RS16070	COG2226	methyltransferase
MPE_RS16075	COG1040	competence protein
MPE_RS16080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MPE_RS16090	COG0840	transmembrane signaling receptor activity
MPE_RS16110	COG1773	rubredoxin
MPE_RS16120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MPE_RS16125	COG0676	glucose-6-phosphate 1-epimerase activity
MPE_RS16140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MPE_RS16145	COG3150	esterase
MPE_RS16150	COG0557	exoribonuclease II activity
MPE_RS16160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MPE_RS16165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MPE_RS16175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPE_RS16180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MPE_RS16185	COG0511	ligase activity, forming carbon-carbon bonds
MPE_RS16190	COG0439	Biotin carboxylase
MPE_RS16195	COG2264	protein methyltransferase activity
MPE_RS16205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MPE_RS16220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPE_RS16255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MPE_RS16270	COG0742	ribosomal rna small subunit methyltransferase
MPE_RS16275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MPE_RS16280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MPE_RS16290	COG0193	aminoacyl-tRNA hydrolase activity
MPE_RS16295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MPE_RS16300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MPE_RS16310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MPE_RS16325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MPE_RS16335	COG1194	a g-specific adenine glycosylase
MPE_RS16340	COG0632	four-way junction helicase activity
MPE_RS16345	COG2197	response regulator
MPE_RS16350	COG3850	Histidine kinase
MPE_RS16355	COG1702	phosphate starvation-inducible protein PhoH
MPE_RS16360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MPE_RS16375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MPE_RS16385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MPE_RS16395	COG2070	2-Nitropropane dioxygenase
MPE_RS16410	COG1560	Kdo2-lipid A biosynthetic process
MPE_RS16420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MPE_RS16425	COG0583	DNA-binding transcription factor activity
MPE_RS16435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MPE_RS16440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MPE_RS16445	COG0045	succinate-CoA ligase (ADP-forming) activity
MPE_RS16450	COG3404	Formiminotransferase-cyclodeaminase
MPE_RS16455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MPE_RS16460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPE_RS16465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MPE_RS16470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MPE_RS16480	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MPE_RS16485	COG0285	dihydrofolate synthase activity
MPE_RS16510	COG3647	Membrane
MPE_RS16520	COG1764	response to oxidative stress
MPE_RS16550	COG0714	Associated with various cellular activities
MPE_RS16565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MPE_RS16580	COG0625	glutathione transferase activity
MPE_RS16585	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MPE_RS16600	COG2326	polyphosphate kinase activity
MPE_RS16605	COG3047	cAMP biosynthetic process
MPE_RS16625	COG0583	DNA-binding transcription factor activity
MPE_RS16630	COG0741	lytic transglycosylase activity
MPE_RS16635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MPE_RS16650	COG0617	tRNA 3'-terminal CCA addition
MPE_RS16660	COG0840	transmembrane signaling receptor activity
MPE_RS16750	COG2249	NAD(P)H dehydrogenase (quinone) activity
MPE_RS16765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPE_RS16770	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MPE_RS16775	COG1942	4-Oxalocrotonate Tautomerase
MPE_RS16795	COG3039	Transposase
MPE_RS16810	COG3550	peptidyl-serine autophosphorylation
MPE_RS16830	COG1420	regulation of RNA biosynthetic process
MPE_RS16835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MPE_RS16840	COG0497	DNA recombination
MPE_RS16845	COG1660	Displays ATPase and GTPase activities
MPE_RS16855	COG0076	glutamate decarboxylase activity
MPE_RS16880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MPE_RS16890	COG0850	regulation of cytokinetic process
MPE_RS16895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MPE_RS16910	COG0477	Major facilitator Superfamily
MPE_RS16955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPE_RS16960	COG1960	acyl-CoA dehydrogenase activity
MPE_RS16985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MPE_RS16990	COG1280	lysine exporter protein (LysE YggA)
MPE_RS16995	COG0183	Belongs to the thiolase family
MPE_RS17000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MPE_RS17005	COG0288	reversible hydration of carbon dioxide
MPE_RS17020	COG3833	ABC-type maltose transport systems, permease component
MPE_RS17025	COG1176	ABC-type spermidine putrescine transport system, permease component I
MPE_RS17050	COG0204	Acyl-transferase
MPE_RS17055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MPE_RS17060	COG0751	glycine-tRNA ligase activity
MPE_RS17065	COG0752	glycyl-tRNA synthetase alpha subunit
MPE_RS17080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MPE_RS17085	COG4535	Mg2 and Co2 transporter CorC
MPE_RS17090	COG0523	cobalamin synthesis protein
MPE_RS17105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MPE_RS17110	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MPE_RS17115	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MPE_RS17175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MPE_RS17180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MPE_RS17230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MPE_RS17240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPE_RS17250	COG4232	protein-disulfide reductase activity
MPE_RS17255	COG0203	ribosomal protein L17
MPE_RS17260	COG0202	RNA polymerase activity
MPE_RS17265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MPE_RS17270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MPE_RS17275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MPE_RS17280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MPE_RS17285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MPE_RS17290	COG0201	protein transport
MPE_RS17295	COG0200	Binds to the 23S rRNA
MPE_RS17300	COG1841	ribosomal large subunit assembly
MPE_RS17305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MPE_RS17310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MPE_RS17315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MPE_RS17320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MPE_RS17325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MPE_RS17330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MPE_RS17335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MPE_RS17340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MPE_RS17345	COG0678	peroxiredoxin activity
MPE_RS17350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MPE_RS17355	COG0255	Belongs to the universal ribosomal protein uL29 family
MPE_RS17360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MPE_RS17365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MPE_RS17370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MPE_RS17375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MPE_RS17380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MPE_RS17385	COG0089	rRNA binding
MPE_RS17390	COG0088	Forms part of the polypeptide exit tunnel
MPE_RS17395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MPE_RS17400	COG0051	transcription antitermination factor activity, RNA binding
MPE_RS17405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MPE_RS17410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MPE_RS17415	COG0049	tRNA binding
MPE_RS17420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MPE_RS17430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MPE_RS17435	COG0085	RNA polymerase activity
MPE_RS17440	COG0222	ribosome binding
MPE_RS17445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MPE_RS17450	COG0081	regulation of translation
MPE_RS17455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MPE_RS17465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MPE_RS17475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MPE_RS17495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MPE_RS17500	COG0134	indole-3-glycerol-phosphate synthase activity
MPE_RS17505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MPE_RS17510	COG0512	Glutamine amidotransferase of anthranilate synthase
MPE_RS17530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MPE_RS17540	COG2967	ApaG domain
MPE_RS17550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MPE_RS17560	COG2072	flavoprotein involved in K transport
MPE_RS17570	COG0438	transferase activity, transferring glycosyl groups
MPE_RS17575	COG2144	transferase activity, transferring acyl groups
MPE_RS17610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPE_RS17620	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MPE_RS17625	COG1116	anion transmembrane transporter activity
MPE_RS17625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPE_RS17630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPE_RS17635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPE_RS17640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPE_RS17650	COG0589	response to stress
MPE_RS17665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MPE_RS17670	COG2197	response regulator
MPE_RS17705	COG1522	sequence-specific DNA binding
MPE_RS17735	COG2353	YceI-like domain
MPE_RS17770	COG3540	Alkaline phosphatase
MPE_RS17790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPE_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
MPE_RS17835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MPE_RS17835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MPE_RS17845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MPE_RS17855	COG3622	Belongs to the hyi family
MPE_RS17860	COG0789	Transcriptional regulator
MPE_RS17865	COG2217	Heavy metal translocating P-type atpase
MPE_RS17880	COG0277	FAD linked oxidase domain protein
MPE_RS17925	COG1595	DNA-templated transcription, initiation
MPE_RS17965	COG2329	Antibiotic biosynthesis monooxygenase
MPE_RS17980	COG1607	acyl-coa hydrolase
MPE_RS18000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MPE_RS18020	COG0482	sulfurtransferase activity
MPE_RS18035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MPE_RS18050	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS18080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPE_RS18085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPE_RS18105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MPE_RS18105	COG2813	Specifically methylates the guanine in position
MPE_RS18110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MPE_RS18115	COG3437	response regulator, receiver
MPE_RS18120	COG0784	Response regulator, receiver
MPE_RS18120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPE_RS18120	COG2205	protein histidine kinase activity
MPE_RS18120	COG2198	Histidine kinase
MPE_RS18165	COG2814	Major facilitator Superfamily
MPE_RS18175	COG1522	sequence-specific DNA binding
MPE_RS18180	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MPE_RS18200	COG5507	3-demethylubiquinone-9 3-methyltransferase
MPE_RS18205	COG0154	amidase activity
MPE_RS18255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MPE_RS18260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPE_RS18285	COG0596	Alpha beta hydrolase
MPE_RS18290	COG0069	glutamate synthase activity
MPE_RS18295	COG2197	response regulator
MPE_RS18315	COG0284	orotidine-5'-phosphate decarboxylase activity
MPE_RS18330	COG0121	glutamine amidotransferase
MPE_RS18380	COG0277	FAD linked oxidase domain protein
MPE_RS18385	COG0277	FAD linked oxidase domain protein
MPE_RS18390	COG0247	lactate metabolic process
MPE_RS18410	COG0697	spore germination
MPE_RS18430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPE_RS18435	COG1739	Uncharacterized protein family UPF0029
MPE_RS18440	COG2974	May be involved in recombination
MPE_RS18445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MPE_RS18450	COG0129	dihydroxy-acid dehydratase activity
MPE_RS18470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MPE_RS18475	COG0596	Alpha beta hydrolase
MPE_RS18480	COG1454	alcohol dehydrogenase
MPE_RS18520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MPE_RS18555	COG1773	rubredoxin
MPE_RS18590	COG0697	spore germination
MPE_RS18605	COG1448	Aminotransferase
MPE_RS18620	COG0386	Belongs to the glutathione peroxidase family
MPE_RS18630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPE_RS18640	COG1902	pentaerythritol trinitrate reductase activity
MPE_RS18660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPE_RS18670	COG4166	transmembrane transport
MPE_RS18680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MPE_RS18685	COG2030	dehydratase
MPE_RS18695	COG0589	response to stress
MPE_RS18705	COG3318	Belongs to the UPF0149 family
MPE_RS18705	COG3012	SEC-C Motif Domain Protein
MPE_RS18720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MPE_RS18745	COG3383	formate dehydrogenase (NAD+) activity
MPE_RS18760	COG0725	ABC transporter, periplasmic molybdate-binding protein
MPE_RS18765	COG4149	molybdate abc transporter
MPE_RS18770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MPE_RS18775	COG2258	MOSC domain
MPE_RS18780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MPE_RS18800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPE_RS18805	COG0577	efflux transmembrane transporter activity
MPE_RS18805	COG1136	(ABC) transporter
MPE_RS18820	COG3128	pkhd-type hydroxylase
MPE_RS18830	COG1477	protein flavinylation
MPE_RS18850	COG4774	siderophore transport
MPE_RS18860	COG0343	queuine tRNA-ribosyltransferase activity
MPE_RS18870	COG4654	Cytochrome c, class I
MPE_RS18875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MPE_RS18880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MPE_RS18885	COG2205	protein histidine kinase activity
MPE_RS18895	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MPE_RS18900	COG0783	Belongs to the Dps family
MPE_RS18905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MPE_RS18910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MPE_RS18915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MPE_RS18940	COG3145	DNA-N1-methyladenine dioxygenase activity
MPE_RS18950	COG2169	Transcriptional regulator
MPE_RS18950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MPE_RS18955	COG0411	ABC transporter
MPE_RS18970	COG0559	Belongs to the binding-protein-dependent transport system permease family
MPE_RS19000	COG2084	Dehydrogenase
MPE_RS19005	COG2823	Periplasmic or secreted lipoprotein
MPE_RS19010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MPE_RS19015	COG0792	nuclease activity
MPE_RS19030	COG0312	modulator of DNA gyrase
MPE_RS19035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MPE_RS19040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MPE_RS19050	COG2096	Adenosyltransferase
MPE_RS19055	COG0277	FAD linked oxidase domain protein
MPE_RS19070	COG2719	SpoVR family
MPE_RS19075	COG2718	Belongs to the UPF0229 family
MPE_RS19080	COG2766	serine protein kinase
MPE_RS19085	COG1475	DNA binding
MPE_RS19095	COG1192	Involved in chromosome partitioning
MPE_RS19110	COG3040	lipid binding
MPE_RS19115	COG0357	Ribosomal RNA small subunit methyltransferase G
MPE_RS19120	COG0445	tRNA wobble uridine modification
MPE_RS19135	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MPE_RS19145	COG1877	trehalose-phosphatase activity
MPE_RS19160	COG2197	response regulator
MPE_RS19170	COG2153	protein acetylation
MPE_RS19175	COG1668	transmembrane transport
MPE_RS19180	COG4555	ABC transporter
MPE_RS19200	COG2095	MarC family integral membrane protein
MPE_RS19205	COG0724	RNA recognition motif
MPE_RS19210	COG4221	oxidoreductase activity
MPE_RS19240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MPE_RS19275	COG3039	Transposase
MPE_RS19295	COG0582	viral genome integration into host DNA
MPE_RS19300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MPE_RS19305	COG0706	membrane insertase activity
MPE_RS19310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MPE_RS19320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MPE_RS19365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MPE_RS19420	COG2259	Doxx family
MPE_RS19495	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MPE_RS19525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPE_RS19525	COG3008	intermembrane lipid transfer
MPE_RS19560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MPE_RS19605	COG1764	response to oxidative stress
MPE_RS19645	COG1716	ATPase activity
MPE_RS19960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPE_RS20010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MPE_RS20050	COG4208	sulfate ABC transporter
MPE_RS20130	COG0745	RESPONSE REGULATOR receiver
MPE_RS20145	COG2205	protein histidine kinase activity
MPE_RS20250	COG0644	oxidoreductase
MPE_RS20315	COG0004	ammonium transporteR
MPE_RS20320	COG0004	ammonium transporteR
MPE_RS20355	COG3158	transport of potassium into the cell
MPE_RS20405	COG3135	benzoate transporter
MPE_RS20415	COG0488	(ABC) transporter
MPE_RS20445	COG0436	Aminotransferase
MPE_RS20470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS20480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPE_RS20490	COG0384	phenazine biosynthesis protein PhzF
MPE_RS20555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MPE_RS20565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MPE_RS20625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MPE_RS20630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MPE_RS20645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MPE_RS20695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MPE_RS20830	COG0598	Magnesium transport protein CorA
MPE_RS21595	COG0318	PFAM AMP-dependent synthetase and ligase
MPE_RS21860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPE_RS21960	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPE_RS21960	COG1024	Enoyl-CoA hydratase
MPE_RS21965	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPE_RS21965	COG1024	Enoyl-CoA hydratase
MPE_RS22060	COG1333	cytochrome c biogenesis protein
MPE_RS22305	COG4221	oxidoreductase activity
MPE_RS22610	COG3015	lipoprotein NlpE involved in copper resistance
MPE_RS22620	COG1215	transferase activity, transferring glycosyl groups
MPE_RS22645	COG1215	transferase activity, transferring glycosyl groups
MPE_RS22655	COG4251	negative regulation of phosphorylation
MPE_RS22780	COG3300	MHYT domain
MPE_RS22780	COG5001	Diguanylate cyclase
MPE_RS22785	COG2205	protein histidine kinase activity
MPE_RS22785	COG2202	Pas domain
MPE_RS22815	COG4251	negative regulation of phosphorylation
MPE_RS22870	COG5001	Diguanylate cyclase
MPE_RS22870	COG3300	MHYT domain
MPE_RS22885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MPE_RS22890	COG5001	Diguanylate cyclase
MPE_RS22890	COG4251	negative regulation of phosphorylation
MPE_RS22890	COG3706	GGDEF domain
MPE_RS22890	COG2203	Gaf domain