locus-tag	class	description
METD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
METD_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
METD_RS00020	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
METD_RS00030	COG0514	ATP-dependent DNA helicase (RecQ)
METD_RS00045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
METD_RS00055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
METD_RS00070	COG0492	ferredoxin-NADP+ reductase activity
METD_RS00090	COG4191	Histidine kinase
METD_RS00090	COG0784	Response regulator, receiver
METD_RS00105	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS00110	COG1802	Transcriptional regulator
METD_RS00125	COG3052	prosthetic group binding
METD_RS00145	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
METD_RS00155	COG1450	Type ii and iii secretion system protein
METD_RS00170	COG2165	general secretion pathway protein
METD_RS00215	COG0500	methyltransferase
METD_RS00215	COG3615	Tellurite resistance protein tehB
METD_RS00280	COG0135	phosphoribosylanthranilate isomerase activity
METD_RS00290	COG0776	regulation of translation
METD_RS00295	COG0616	signal peptide processing
METD_RS00305	COG0539	negative regulation of cytoplasmic translation
METD_RS00310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
METD_RS00325	COG1741	Belongs to the pirin family
METD_RS00330	COG0475	glutathione-regulated potassium exporter activity
METD_RS00330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
METD_RS00360	COG0488	(ABC) transporter
METD_RS00395	COG0438	transferase activity, transferring glycosyl groups
METD_RS00400	COG0438	transferase activity, transferring glycosyl groups
METD_RS00405	COG1216	Glycosyl transferase, family 2
METD_RS00420	COG0297	glycogen (starch) synthase activity
METD_RS00465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
METD_RS00470	COG0277	FAD linked oxidase domain protein
METD_RS00480	COG0437	4 iron, 4 sulfur cluster binding
METD_RS00545	COG0753	catalase activity
METD_RS00560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
METD_RS00570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
METD_RS00575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
METD_RS00580	COG2205	protein histidine kinase activity
METD_RS00605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
METD_RS00615	COG1260	myo-inositol-1-phosphate synthase
METD_RS00645	COG1032	radical SAM domain protein
METD_RS00650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS00675	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS00705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
METD_RS00710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
METD_RS00715	COG0443	Heat shock 70 kDa protein
METD_RS00725	COG0546	phosphoglycolate phosphatase activity
METD_RS00735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
METD_RS00750	COG1309	transcriptional regulator
METD_RS00755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
METD_RS00765	COG3510	cephalosporin hydroxylase
METD_RS00770	COG0604	alcohol dehydrogenase
METD_RS00775	COG0753	catalase activity
METD_RS00780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
METD_RS00780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
METD_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS00795	COG0640	Transcriptional regulator
METD_RS00800	COG0180	Tryptophanyl-tRNA synthetase
METD_RS00805	COG0066	3-isopropylmalate dehydratase activity
METD_RS00810	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
METD_RS00815	COG1703	isobutyryl-CoA mutase activity
METD_RS00835	COG1388	LysM domain
METD_RS00835	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS00845	COG0420	3'-5' exonuclease activity
METD_RS00850	COG0419	ATPase involved in DNA repair
METD_RS00855	COG2223	nitrite transmembrane transporter activity
METD_RS00870	COG2226	methyltransferase
METD_RS00885	COG0494	nUDIX hydrolase
METD_RS00895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
METD_RS00940	COG0210	DNA helicase
METD_RS00960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
METD_RS00980	COG0745	RESPONSE REGULATOR receiver
METD_RS00990	COG1116	anion transmembrane transporter activity
METD_RS00995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS01000	COG1280	lysine exporter protein (LysE YggA)
METD_RS01010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
METD_RS01015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
METD_RS01030	COG0077	Prephenate dehydratase
METD_RS01030	COG1605	Chorismate mutase
METD_RS01035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
METD_RS01040	COG3474	cytochrome
METD_RS01045	COG4166	transmembrane transport
METD_RS01050	COG4166	transmembrane transport
METD_RS01055	COG4174	ABC transporter (Permease)
METD_RS01070	COG0463	Glycosyl transferase, family 2
METD_RS01095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
METD_RS01165	COG2202	Pas domain
METD_RS01165	COG3920	Histidine kinase
METD_RS01175	COG5001	Diguanylate cyclase
METD_RS01175	COG2203	Gaf domain
METD_RS01175	COG4251	negative regulation of phosphorylation
METD_RS01175	COG3706	GGDEF domain
METD_RS01180	COG0583	DNA-binding transcription factor activity
METD_RS01185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS01190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS01195	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS01310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
METD_RS01320	COG0484	heat shock protein binding
METD_RS01325	COG3243	poly(R)-hydroxyalkanoic acid synthase
METD_RS01330	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
METD_RS01370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
METD_RS01390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS01430	COG0745	RESPONSE REGULATOR receiver
METD_RS01435	COG4566	intracellular signal transduction
METD_RS01440	COG4191	Histidine kinase
METD_RS01470	COG5001	Diguanylate cyclase
METD_RS01475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
METD_RS01495	COG1554	hydrolase, family 65, central catalytic
METD_RS01500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
METD_RS01505	COG0640	Transcriptional regulator
METD_RS01535	COG1388	LysM domain
METD_RS01535	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS01555	COG2391	methyltransferase activity
METD_RS01615	COG3706	GGDEF domain
METD_RS01625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
METD_RS01630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
METD_RS01635	COG2010	Cytochrome c
METD_RS01635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS01665	COG4566	intracellular signal transduction
METD_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS01690	COG0667	Aldo Keto reductase
METD_RS01715	COG0659	secondary active sulfate transmembrane transporter activity
METD_RS01720	COG0123	including yeast histone deacetylase and acetoin utilization protein
METD_RS01755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS01910	COG3237	CsbD-like
METD_RS01920	COG3781	membrane
METD_RS01925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
METD_RS01930	COG2967	ApaG domain
METD_RS01945	COG2116	formate transmembrane transporter activity
METD_RS01950	COG1546	Belongs to the CinA family
METD_RS01950	COG1058	Belongs to the CinA family
METD_RS01975	COG0842	Transport permease protein
METD_RS01980	COG1131	(ABC) transporter
METD_RS02025	COG0243	molybdopterin cofactor binding
METD_RS02025	COG3383	formate dehydrogenase (NAD+) activity
METD_RS02030	COG0437	4 iron, 4 sulfur cluster binding
METD_RS02090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
METD_RS02095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
METD_RS02100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
METD_RS02120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
METD_RS02125	COG0792	nuclease activity
METD_RS02135	COG1732	Glycine betaine
METD_RS02140	COG1174	glycine betaine transport
METD_RS02145	COG1174	glycine betaine transport
METD_RS02150	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS02165	COG2759	Belongs to the formate--tetrahydrofolate ligase family
METD_RS02190	COG0745	RESPONSE REGULATOR receiver
METD_RS02195	COG0196	riboflavin kinase activity
METD_RS02225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
METD_RS02230	COG1338	Plays a role in the flagellum-specific transport system
METD_RS02235	COG2259	Doxx family
METD_RS02255	COG4957	zinc ion binding
METD_RS02270	COG2166	iron-sulfur cluster assembly
METD_RS02275	COG3920	Histidine kinase
METD_RS02300	COG0308	aminopeptidase N
METD_RS02305	COG2202	Pas domain
METD_RS02305	COG2205	protein histidine kinase activity
METD_RS02315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
METD_RS02325	COG1324	tolerance protein
METD_RS02330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
METD_RS02360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
METD_RS02370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
METD_RS02375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
METD_RS02380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
METD_RS02385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
METD_RS02395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
METD_RS02400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS02405	COG1129	ABC transporter
METD_RS02405	COG0842	Transport permease protein
METD_RS02410	COG0842	Transport permease protein
METD_RS02415	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
METD_RS02430	COG3842	ATPase activity
METD_RS02435	COG1840	ABC-type Fe3 transport system, periplasmic component
METD_RS02465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS02485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
METD_RS02495	COG4208	sulfate ABC transporter
METD_RS02500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
METD_RS02540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
METD_RS02545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
METD_RS02555	COG0438	transferase activity, transferring glycosyl groups
METD_RS02555	COG1216	Glycosyl transferase, family 2
METD_RS02590	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
METD_RS02600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
METD_RS02605	COG0047	phosphoribosylformylglycinamidine synthase activity
METD_RS02610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
METD_RS02615	COG0483	inositol monophosphate 1-phosphatase activity
METD_RS02620	COG0352	thiamine-phosphate diphosphorylase activity
METD_RS02625	COG2022	thiamine diphosphate biosynthetic process
METD_RS02635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
METD_RS02635	COG2022	thiamine diphosphate biosynthetic process
METD_RS02660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
METD_RS02670	COG3386	PFAM SMP-30 Gluconolaconase
METD_RS02685	COG0505	Belongs to the CarA family
METD_RS02700	COG1815	bacterial-type flagellum-dependent cell motility
METD_RS02705	COG1558	bacterial-type flagellum-dependent cell motility
METD_RS02710	COG1677	Flagellar hook-basal body complex protein FliE
METD_RS02715	COG4786	Flagellar basal body rod
METD_RS02725	COG1706	bacterial-type flagellum-dependent cell motility
METD_RS02735	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
METD_RS02745	COG1338	Plays a role in the flagellum-specific transport system
METD_RS02795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
METD_RS02800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
METD_RS02805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
METD_RS02825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
METD_RS02830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
METD_RS02865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
METD_RS02875	COG0228	four-way junction DNA binding
METD_RS02880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
METD_RS02900	COG0336	Belongs to the RNA methyltransferase TrmD family
METD_RS02905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
METD_RS02910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
METD_RS02930	COG0534	Mate efflux family protein
METD_RS02935	COG1132	(ABC) transporter
METD_RS02940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
METD_RS02945	COG0840	transmembrane signaling receptor activity
METD_RS02960	COG2268	Band 7 protein
METD_RS02965	COG4774	siderophore transport
METD_RS02970	COG0408	coproporphyrinogen oxidase activity
METD_RS02975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
METD_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
METD_RS03010	COG4786	Flagellar basal body rod
METD_RS03015	COG1157	protein secretion by the type III secretion system
METD_RS03040	COG5443	negative regulation of bacterial-type flagellum assembly
METD_RS03045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
METD_RS03050	COG4794	Type iii secretion
METD_RS03055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
METD_RS03085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
METD_RS03105	COG2205	protein histidine kinase activity
METD_RS03115	COG1294	oxidase, subunit
METD_RS03120	COG2271	Major facilitator Superfamily
METD_RS03125	COG2814	Major facilitator Superfamily
METD_RS03135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
METD_RS03145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
METD_RS03170	COG0123	including yeast histone deacetylase and acetoin utilization protein
METD_RS03205	COG0640	Transcriptional regulator
METD_RS03210	COG0519	Catalyzes the synthesis of GMP from XMP
METD_RS03210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
METD_RS03215	COG0667	Aldo Keto reductase
METD_RS03220	COG2207	Transcriptional regulator
METD_RS03275	COG0640	Transcriptional regulator
METD_RS03290	COG0730	response to heat
METD_RS03315	COG4232	protein-disulfide reductase activity
METD_RS03325	COG1388	LysM domain
METD_RS03325	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS03350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
METD_RS03415	COG0737	Belongs to the 5'-nucleotidase family
METD_RS03450	COG0785	Cytochrome C biogenesis protein
METD_RS03460	COG0640	Transcriptional regulator
METD_RS03480	COG0659	secondary active sulfate transmembrane transporter activity
METD_RS03515	COG1012	belongs to the aldehyde dehydrogenase family
METD_RS03520	COG2271	Major facilitator Superfamily
METD_RS03525	COG0583	DNA-binding transcription factor activity
METD_RS03545	COG2855	membrane
METD_RS03560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
METD_RS03570	COG0028	Belongs to the TPP enzyme family
METD_RS03575	COG1414	Transcriptional regulator
METD_RS03580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
METD_RS03605	COG1396	sequence-specific DNA binding
METD_RS03610	COG1396	sequence-specific DNA binding
METD_RS03715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
METD_RS03725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
METD_RS03790	COG5001	Diguanylate cyclase
METD_RS03795	COG0840	transmembrane signaling receptor activity
METD_RS03795	COG2972	Histidine kinase
METD_RS03860	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS03875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS03905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
METD_RS03965	COG4974	Belongs to the 'phage' integrase family
METD_RS03970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
METD_RS04000	COG5001	Diguanylate cyclase
METD_RS04010	COG0583	DNA-binding transcription factor activity
METD_RS04075	COG0840	transmembrane signaling receptor activity
METD_RS04155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
METD_RS04180	COG0745	RESPONSE REGULATOR receiver
METD_RS04195	COG0110	maltose O-acetyltransferase activity
METD_RS04200	COG0280	phosphate acetyltransferase
METD_RS04200	COG0281	malic enzyme
METD_RS04240	COG2080	2 iron, 2 sulfur cluster binding
METD_RS04245	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
METD_RS04250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS04255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
METD_RS04265	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
METD_RS04310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
METD_RS04320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
METD_RS04325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
METD_RS04325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
METD_RS04335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
METD_RS04350	COG0791	NLP P60 protein
METD_RS04370	COG0714	Associated with various cellular activities
METD_RS04385	COG2304	oxidoreductase activity
METD_RS04425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
METD_RS04435	COG2202	Pas domain
METD_RS04435	COG3920	Histidine kinase
METD_RS04440	COG0318	PFAM AMP-dependent synthetase and ligase
METD_RS04455	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
METD_RS04470	COG0693	protein deglycase activity
METD_RS04490	COG1278	Cold shock
METD_RS04510	COG2814	Major facilitator Superfamily
METD_RS04515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
METD_RS04520	COG1127	ABC transporter
METD_RS04535	COG0483	inositol monophosphate 1-phosphatase activity
METD_RS04545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
METD_RS04610	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
METD_RS04615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
METD_RS04620	COG2205	protein histidine kinase activity
METD_RS04635	COG3920	Histidine kinase
METD_RS04640	COG0154	amidase activity
METD_RS04660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
METD_RS04675	COG0277	FAD linked oxidase domain protein
METD_RS04685	COG1846	Transcriptional regulator
METD_RS04700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
METD_RS04705	COG2983	Belongs to the UPF0260 family
METD_RS04730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
METD_RS04735	COG2094	Belongs to the DNA glycosylase MPG family
METD_RS04740	COG0328	RNA-DNA hybrid ribonuclease activity
METD_RS04760	COG0189	ligase activity
METD_RS04765	COG0025	NhaP-type Na H and K H
METD_RS04770	COG3023	N-Acetylmuramoyl-L-alanine amidase
METD_RS04775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
METD_RS04785	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
METD_RS04795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
METD_RS04800	COG5001	Diguanylate cyclase
METD_RS04805	COG0745	RESPONSE REGULATOR receiver
METD_RS04815	COG1749	Flagellar hook protein flgE
METD_RS04835	COG2890	protein-(glutamine-N5) methyltransferase activity
METD_RS04840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
METD_RS04850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
METD_RS04855	COG0527	aspartate kinase activity
METD_RS04860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
METD_RS04870	COG0604	alcohol dehydrogenase
METD_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS04870	COG3321	synthase
METD_RS04875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
METD_RS04880	COG2353	YceI-like domain
METD_RS04885	COG0632	four-way junction helicase activity
METD_RS04895	COG0784	Response regulator, receiver
METD_RS04905	COG1959	2 iron, 2 sulfur cluster binding
METD_RS04910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
METD_RS04910	COG1017	nitric oxide dioxygenase activity
METD_RS04925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
METD_RS04945	COG0583	DNA-binding transcription factor activity
METD_RS04950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
METD_RS04970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS05000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
METD_RS05015	COG1982	Orn Lys Arg decarboxylase major
METD_RS05025	COG0521	Mo-molybdopterin cofactor biosynthetic process
METD_RS05030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
METD_RS05055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
METD_RS05060	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS05065	COG5001	Diguanylate cyclase
METD_RS05065	COG3300	MHYT domain
METD_RS05080	COG0564	pseudouridine synthase activity
METD_RS05105	COG4774	siderophore transport
METD_RS05180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS05200	COG3177	Filamentation induced by cAMP protein fic
METD_RS05410	COG2801	Transposase and inactivated derivatives
METD_RS05440	COG3034	peptidoglycan biosynthetic process
METD_RS05445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
METD_RS05455	COG0789	Transcriptional regulator
METD_RS05520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS05560	COG2801	Transposase and inactivated derivatives
METD_RS05575	COG1785	Belongs to the alkaline phosphatase family
METD_RS05590	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS05640	COG0431	NADPH-dependent FMN reductase
METD_RS05655	COG1393	Belongs to the ArsC family
METD_RS05660	COG0798	PFAM Bile acid sodium symporter
METD_RS05675	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS05770	COG1937	Protein conserved in bacteria
METD_RS05815	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS05840	COG1595	DNA-templated transcription, initiation
METD_RS05870	COG2132	Multicopper oxidase
METD_RS05930	COG0431	NADPH-dependent FMN reductase
METD_RS05945	COG0798	PFAM Bile acid sodium symporter
METD_RS05960	COG1404	Belongs to the peptidase S8 family
METD_RS05965	COG1595	DNA-templated transcription, initiation
METD_RS06025	COG0789	Transcriptional regulator
METD_RS06065	COG5489	Protein of unknown function (DUF736)
METD_RS06070	COG1475	DNA binding
METD_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06280	COG3386	PFAM SMP-30 Gluconolaconase
METD_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06300	COG2080	2 iron, 2 sulfur cluster binding
METD_RS06305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
METD_RS06310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS06325	COG1162	GTPase activity
METD_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06470	COG0739	heme binding
METD_RS06480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
METD_RS06495	COG0326	Molecular chaperone. Has ATPase activity
METD_RS06515	COG2226	methyltransferase
METD_RS06555	COG1797	cobyrinic acid a,c-diamide synthase activity
METD_RS06560	COG1396	sequence-specific DNA binding
METD_RS06570	COG2223	nitrite transmembrane transporter activity
METD_RS06575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
METD_RS06580	COG0735	belongs to the Fur family
METD_RS06585	COG1121	(ABC) transporter
METD_RS06605	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
METD_RS06615	COG1381	Involved in DNA repair and RecF pathway recombination
METD_RS06620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
METD_RS06625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
METD_RS06630	COG0683	leucine binding
METD_RS06640	COG3608	succinylglutamate desuccinylase aspartoacylase
METD_RS06640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
METD_RS06650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
METD_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06670	COG3932	Exopolysaccharide synthesis, ExoD
METD_RS06675	COG1136	(ABC) transporter
METD_RS06685	COG0442	prolyl-tRNA aminoacylation
METD_RS06695	COG0346	lactoylglutathione lyase activity
METD_RS06710	COG1007	ATP synthesis coupled electron transport
METD_RS06725	COG0713	ATP synthesis coupled electron transport
METD_RS06735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
METD_RS06740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
METD_RS06750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
METD_RS06760	COG0649	NAD binding
METD_RS06765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
METD_RS06770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
METD_RS06775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
METD_RS06790	COG3794	PFAM blue (type 1) copper domain protein
METD_RS06795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
METD_RS06800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
METD_RS06815	COG0492	ferredoxin-NADP+ reductase activity
METD_RS06820	COG0583	DNA-binding transcription factor activity
METD_RS06825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
METD_RS06830	COG0511	ligase activity, forming carbon-carbon bonds
METD_RS06840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
METD_RS06865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
METD_RS06880	COG2963	transposase activity
METD_RS06895	COG2801	Transposase and inactivated derivatives
METD_RS06905	COG2801	Transposase and inactivated derivatives
METD_RS06925	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS06930	COG0583	DNA-binding transcription factor activity
METD_RS06950	COG1994	Peptidase M50
METD_RS06960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
METD_RS06975	COG0484	heat shock protein binding
METD_RS06995	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS07045	COG3920	Histidine kinase
METD_RS07050	COG3118	belongs to the thioredoxin family
METD_RS07065	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS07070	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS07080	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS07085	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS07110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS07160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
METD_RS07165	COG0431	NADPH-dependent FMN reductase
METD_RS07175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
METD_RS07185	COG2323	membrane
METD_RS07190	COG0251	oxidation-reduction process
METD_RS07200	COG0583	DNA-binding transcription factor activity
METD_RS07210	COG0583	DNA-binding transcription factor activity
METD_RS07215	COG2358	TRAP transporter, solute receptor (TAXI family
METD_RS07220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS07225	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
METD_RS07240	COG1295	ribonuclease BN
METD_RS07270	COG3158	transport of potassium into the cell
METD_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS07295	COG1408	metallophosphoesterase
METD_RS07350	COG2815	serine threonine protein kinase
METD_RS07350	COG0515	serine threonine protein kinase
METD_RS07410	COG2391	methyltransferase activity
METD_RS07425	COG0640	Transcriptional regulator
METD_RS07430	COG1116	anion transmembrane transporter activity
METD_RS07430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS07435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS07440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS07445	COG0446	pyridine nucleotide-disulphide oxidoreductase
METD_RS07465	COG4977	sequence-specific DNA binding
METD_RS07475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
METD_RS07515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS07540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS07540	COG1116	anion transmembrane transporter activity
METD_RS07545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS07555	COG1960	acyl-CoA dehydrogenase activity
METD_RS07565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS07585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS07590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
METD_RS07605	COG0492	ferredoxin-NADP+ reductase activity
METD_RS07610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
METD_RS07630	COG1278	Cold shock
METD_RS07655	COG2202	Pas domain
METD_RS07655	COG3920	Histidine kinase
METD_RS07665	COG4716	Myosin-crossreactive antigen
METD_RS07680	COG0830	nickel cation binding
METD_RS07685	COG0832	Belongs to the urease beta subunit family
METD_RS07685	COG0831	urea catabolic process
METD_RS07690	COG0804	urea catabolic process
METD_RS07695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
METD_RS07700	COG0829	nickel cation binding
METD_RS07735	COG4191	Histidine kinase
METD_RS07790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
METD_RS07795	COG1802	Transcriptional regulator
METD_RS07800	COG0523	cobalamin synthesis protein
METD_RS07805	COG1686	Belongs to the peptidase S11 family
METD_RS07810	COG0602	queuosine metabolic process
METD_RS07830	COG0720	synthase
METD_RS07835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
METD_RS07840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
METD_RS07875	COG0297	glycogen (starch) synthase activity
METD_RS07895	COG0642	Histidine kinase
METD_RS07900	COG0745	RESPONSE REGULATOR receiver
METD_RS07930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
METD_RS07960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
METD_RS07965	COG1403	HNH endonuclease
METD_RS07970	COG3453	Protein conserved in bacteria
METD_RS07970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS07975	COG0024	Methionine aminopeptidase
METD_RS07990	COG3246	L-lysine catabolic process to acetate
METD_RS08000	COG4191	Histidine kinase
METD_RS08005	COG1116	anion transmembrane transporter activity
METD_RS08010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS08015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS08020	COG0850	regulation of cytokinetic process
METD_RS08030	COG1217	gtp-binding protein TYPA
METD_RS08035	COG2972	Histidine kinase
METD_RS08035	COG0840	transmembrane signaling receptor activity
METD_RS08040	COG0850	regulation of cytokinetic process
METD_RS08060	COG3386	PFAM SMP-30 Gluconolaconase
METD_RS08065	COG3387	PFAM Glycoside hydrolase 15-related
METD_RS08070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
METD_RS08085	COG4166	transmembrane transport
METD_RS08095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
METD_RS08105	COG0444	Belongs to the ABC transporter superfamily
METD_RS08170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
METD_RS08195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
METD_RS08200	COG0004	ammonium transporteR
METD_RS08210	COG0829	nickel cation binding
METD_RS08215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
METD_RS08220	COG0830	nickel cation binding
METD_RS08240	COG0804	urea catabolic process
METD_RS08250	COG0831	urea catabolic process
METD_RS08430	COG0410	ABC transporter
METD_RS08440	COG1172	Belongs to the binding-protein-dependent transport system permease family
METD_RS08470	COG2133	pyrroloquinoline quinone binding
METD_RS08475	COG0596	Alpha beta hydrolase
METD_RS08495	COG3181	Tripartite tricarboxylate transporter family receptor
METD_RS08500	COG0300	oxidoreductase activity
METD_RS08505	COG0588	phosphoglycerate mutase activity
METD_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS08560	COG2124	cytochrome p450
METD_RS08560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
METD_RS08565	COG5001	Diguanylate cyclase
METD_RS08610	COG0477	Major facilitator Superfamily
METD_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS08675	COG3246	L-lysine catabolic process to acetate
METD_RS08680	COG0589	response to stress
METD_RS08690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS08695	COG1132	(ABC) transporter
METD_RS08705	COG1271	oxidase subunit
METD_RS08710	COG1294	oxidase, subunit
METD_RS08720	COG1349	DNA-binding transcription factor activity
METD_RS08725	COG0154	amidase activity
METD_RS08740	COG1215	transferase activity, transferring glycosyl groups
METD_RS08845	COG1999	signal sequence binding
METD_RS08870	COG1802	Transcriptional regulator
METD_RS08875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
METD_RS08915	COG2373	Large extracellular alpha-helical protein
METD_RS08920	COG4953	penicillin-binding protein 1C
METD_RS08925	COG2076	Multidrug Resistance protein
METD_RS08965	COG3088	subunit of a heme lyase
METD_RS08970	COG1138	Cytochrome C-type biogenesis protein
METD_RS08975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
METD_RS08980	COG4235	cytochrome complex assembly
METD_RS09020	COG3772	lysozyme
METD_RS09110	COG4695	Portal protein
METD_RS09195	COG0114	fumarate hydratase activity
METD_RS09220	COG0840	transmembrane signaling receptor activity
METD_RS09225	COG4191	Histidine kinase
METD_RS09225	COG0784	Response regulator, receiver
METD_RS09235	COG2207	Transcriptional regulator
METD_RS09235	COG3708	Transcriptional regulator
METD_RS09255	COG0714	Associated with various cellular activities
METD_RS09270	COG0494	nUDIX hydrolase
METD_RS09280	COG0617	tRNA 3'-terminal CCA addition
METD_RS09285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
METD_RS09295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
METD_RS09300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
METD_RS09305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
METD_RS09315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
METD_RS09330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
METD_RS09350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
METD_RS09370	COG1051	belongs to the nudix hydrolase family
METD_RS09385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
METD_RS09390	COG0237	dephospho-CoA kinase activity
METD_RS09395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
METD_RS09405	COG0424	maF-like protein
METD_RS09415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
METD_RS09420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
METD_RS09430	COG1981	membrane
METD_RS09440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
METD_RS09445	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
METD_RS09490	COG0314	molybdopterin synthase activity
METD_RS09500	COG0579	oxidoreductase
METD_RS09505	COG3552	Protein containing von Willebrand factor type A (VWA) domain
METD_RS09515	COG0714	Associated with various cellular activities
METD_RS09530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
METD_RS09535	COG3609	addiction module antidote protein, CC2985 family
METD_RS09545	COG1573	uracil-dna glycosylase
METD_RS09555	COG0284	orotidine-5'-phosphate decarboxylase activity
METD_RS09585	COG1051	belongs to the nudix hydrolase family
METD_RS09590	COG0288	reversible hydration of carbon dioxide
METD_RS09595	COG1218	3'(2'),5'-bisphosphate nucleotidase
METD_RS09605	COG2198	Histidine kinase
METD_RS09605	COG0643	Histidine kinase
METD_RS09605	COG0784	Response regulator, receiver
METD_RS09620	COG2201	protein-glutamate methylesterase activity
METD_RS09635	COG1984	allophanate hydrolase subunit 2
METD_RS09670	COG2086	electron transfer activity
METD_RS09675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
METD_RS09680	COG1250	3-hydroxyacyl-CoA dehydrogenase
METD_RS09690	COG3321	synthase
METD_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS09690	COG0604	alcohol dehydrogenase
METD_RS09700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
METD_RS09710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
METD_RS09735	COG0124	histidyl-tRNA synthetase
METD_RS09740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
METD_RS09755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
METD_RS09775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
METD_RS09780	COG0028	Belongs to the TPP enzyme family
METD_RS09790	COG1253	flavin adenine dinucleotide binding
METD_RS09810	COG0671	phosphoesterase, PA-phosphatase related
METD_RS09825	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
METD_RS09830	COG2171	N-acyltransferase activity
METD_RS09840	COG0745	RESPONSE REGULATOR receiver
METD_RS09855	COG0495	leucyl-tRNA aminoacylation
METD_RS09860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
METD_RS09875	COG0445	tRNA wobble uridine modification
METD_RS09920	COG0287	Prephenate dehydrogenase
METD_RS09925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
METD_RS09935	COG4774	siderophore transport
METD_RS09940	COG3158	transport of potassium into the cell
METD_RS09945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
METD_RS09955	COG2226	methyltransferase
METD_RS09995	COG1612	heme a metabolic process
METD_RS10000	COG1272	protein, Hemolysin III
METD_RS10010	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
METD_RS10020	COG5442	Flagellar protein FlaF
METD_RS10045	COG0848	biopolymer transport protein
METD_RS10075	COG0438	transferase activity, transferring glycosyl groups
METD_RS10090	COG0438	transferase activity, transferring glycosyl groups
METD_RS10095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
METD_RS10100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
METD_RS10105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
METD_RS10110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
METD_RS10110	COG0072	phenylalanine-tRNA ligase activity
METD_RS10115	COG0653	protein targeting
METD_RS10130	COG0101	tRNA pseudouridine synthase activity
METD_RS10135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
METD_RS10140	COG0242	peptide deformylase activity
METD_RS10150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
METD_RS10155	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
METD_RS10160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
METD_RS10165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
METD_RS10175	COG0039	L-malate dehydrogenase activity
METD_RS10180	COG0045	succinate-CoA ligase (ADP-forming) activity
METD_RS10185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
METD_RS10195	COG0508	dehydrogenase complex catalyzes the overall conversion of
METD_RS10200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
METD_RS10205	COG4191	Histidine kinase
METD_RS10205	COG0784	Response regulator, receiver
METD_RS10220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
METD_RS10220	COG0446	pyridine nucleotide-disulphide oxidoreductase
METD_RS10230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
METD_RS10240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
METD_RS10245	COG2218	PFAM glutamate synthase alpha subunit domain protein
METD_RS10250	COG0069	glutamate synthase activity
METD_RS10280	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
METD_RS10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS10305	COG2197	response regulator
METD_RS10320	COG5002	protein histidine kinase activity
METD_RS10320	COG0784	Response regulator, receiver
METD_RS10325	COG0784	Response regulator, receiver
METD_RS10325	COG4191	Histidine kinase
METD_RS10335	COG0583	DNA-binding transcription factor activity
METD_RS10365	COG1335	isochorismatase
METD_RS10375	COG0583	DNA-binding transcription factor activity
METD_RS10385	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS10385	COG1388	LysM domain
METD_RS10390	COG0583	DNA-binding transcription factor activity
METD_RS10435	COG0154	amidase activity
METD_RS10440	COG2233	PERMEase
METD_RS10475	COG3845	ABC transporter
METD_RS10500	COG1079	Belongs to the binding-protein-dependent transport system permease family
METD_RS10505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
METD_RS10515	COG3845	ABC transporter
METD_RS10550	COG0318	PFAM AMP-dependent synthetase and ligase
METD_RS10555	COG2249	NAD(P)H dehydrogenase (quinone) activity
METD_RS10580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS10595	COG0583	DNA-binding transcription factor activity
METD_RS10600	COG0402	S-adenosylhomocysteine deaminase activity
METD_RS10615	COG0583	DNA-binding transcription factor activity
METD_RS10620	COG0402	S-adenosylhomocysteine deaminase activity
METD_RS10625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS10625	COG2080	2 iron, 2 sulfur cluster binding
METD_RS10635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS10640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS10645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS10650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
METD_RS10665	COG0251	oxidation-reduction process
METD_RS10680	COG1309	transcriptional regulator
METD_RS10685	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
METD_RS10690	COG3257	ureidoglycine aminohydrolase activity
METD_RS10700	COG0583	DNA-binding transcription factor activity
METD_RS10705	COG3648	Uricase
METD_RS10705	COG3195	allantoin biosynthetic process
METD_RS10710	COG2351	hydroxyisourate hydrolase activity
METD_RS10715	COG2354	Protein conserved in bacteria
METD_RS10720	COG5001	Diguanylate cyclase
METD_RS10755	COG0405	Gamma-glutamyltransferase
METD_RS10780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
METD_RS10780	COG2813	Specifically methylates the guanine in position
METD_RS10785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
METD_RS10795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
METD_RS10810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
METD_RS10835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
METD_RS10840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
METD_RS10845	COG3118	belongs to the thioredoxin family
METD_RS10880	COG0523	cobalamin synthesis protein
METD_RS10900	COG3106	COG3106 Predicted ATPase
METD_RS10905	COG3768	UPF0283 membrane protein
METD_RS10920	COG0019	diaminopimelate decarboxylase activity
METD_RS10945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
METD_RS10950	COG0438	transferase activity, transferring glycosyl groups
METD_RS10960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
METD_RS10965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
METD_RS10970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
METD_RS10975	COG3404	Formiminotransferase-cyclodeaminase
METD_RS10980	COG0045	succinate-CoA ligase (ADP-forming) activity
METD_RS10985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
METD_RS10990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
METD_RS11005	COG0412	Dienelactone hydrolase
METD_RS11010	COG2154	pterin-4-alpha-carbinolamine dehydratase
METD_RS11045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
METD_RS11050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
METD_RS11055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
METD_RS11070	COG0535	radical SAM domain protein
METD_RS11075	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
METD_RS11080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
METD_RS11105	COG2218	PFAM glutamate synthase alpha subunit domain protein
METD_RS11110	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
METD_RS11115	COG1229	Formylmethanofuran dehydrogenase subunit A
METD_RS11120	COG1029	Formylmethanofuran dehydrogenase, subunit B
METD_RS11130	COG0702	epimerase
METD_RS11135	COG1181	Belongs to the D-alanine--D-alanine ligase family
METD_RS11145	COG0189	ligase activity
METD_RS11155	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
METD_RS11175	COG3391	amine dehydrogenase activity
METD_RS11235	COG1131	(ABC) transporter
METD_RS11265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
METD_RS11285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
METD_RS11290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
METD_RS11310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
METD_RS11380	COG2223	nitrite transmembrane transporter activity
METD_RS11390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
METD_RS11395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
METD_RS11410	COG1192	Involved in chromosome partitioning
METD_RS11420	COG1414	Transcriptional regulator
METD_RS11435	COG0629	single-stranded DNA binding
METD_RS11440	COG1414	Transcriptional regulator
METD_RS11445	COG1475	DNA binding
METD_RS11450	COG1192	Involved in chromosome partitioning
METD_RS11510	COG0464	growth
METD_RS11560	COG5489	Protein of unknown function (DUF736)
METD_RS11565	COG0174	glutamine synthetase
METD_RS11575	COG4227	nucleotidyltransferase activity
METD_RS11605	COG1475	DNA binding
METD_RS11675	COG3608	succinylglutamate desuccinylase aspartoacylase
METD_RS11675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
METD_RS11695	COG1910	domain protein
METD_RS11705	COG0659	secondary active sulfate transmembrane transporter activity
METD_RS11720	COG3328	transposase activity
METD_RS11760	COG3328	transposase activity
METD_RS11780	COG0625	glutathione transferase activity
METD_RS11785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
METD_RS11790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
METD_RS11795	COG0156	8-amino-7-oxononanoate synthase activity
METD_RS11840	COG0606	chelatase, subunit chli
METD_RS11845	COG0625	glutathione transferase activity
METD_RS11870	COG1607	acyl-coa hydrolase
METD_RS11880	COG0741	lytic transglycosylase activity
METD_RS11885	COG0243	molybdopterin cofactor binding
METD_RS11890	COG4172	Belongs to the ABC transporter superfamily
METD_RS11895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
METD_RS11920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
METD_RS11925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS11930	COG1562	ergosterol biosynthetic process
METD_RS11935	COG1562	ergosterol biosynthetic process
METD_RS11940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
METD_RS11945	COG1657	PFAM Prenyltransferase squalene oxidase
METD_RS11955	COG0156	8-amino-7-oxononanoate synthase activity
METD_RS11960	COG0604	alcohol dehydrogenase
METD_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS11960	COG3321	synthase
METD_RS11965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
METD_RS11970	COG0438	transferase activity, transferring glycosyl groups
METD_RS11970	COG1216	Glycosyl transferase, family 2
METD_RS11990	COG4303	Ethanolamine ammonia lyase large subunit
METD_RS11995	COG4302	ethanolamine ammonia-lyase activity
METD_RS12000	COG0129	dihydroxy-acid dehydratase activity
METD_RS12035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
METD_RS12050	COG1494	fructose-1,6-bisphosphatase
METD_RS12075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
METD_RS12080	COG2264	protein methyltransferase activity
METD_RS12105	COG1271	oxidase subunit
METD_RS12115	COG3706	GGDEF domain
METD_RS12130	COG0672	)-iron permease
METD_RS12140	COG5328	Belongs to the UPF0262 family
METD_RS12145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
METD_RS12160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
METD_RS12165	COG0156	8-amino-7-oxononanoate synthase activity
METD_RS12185	COG2824	Alkylphosphonate utilization operon protein PhnA
METD_RS12200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
METD_RS12215	COG1561	YicC-like family, N-terminal region
METD_RS12220	COG0194	GDP metabolic process
METD_RS12225	COG1132	(ABC) transporter
METD_RS12230	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS12235	COG0778	Nitroreductase
METD_RS12245	COG4774	siderophore transport
METD_RS12250	COG0800	Aldolase
METD_RS12255	COG0129	dihydroxy-acid dehydratase activity
METD_RS12295	COG2879	small protein
METD_RS12300	COG1966	Carbon starvation protein
METD_RS12310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
METD_RS12315	COG1704	LemA family
METD_RS12325	COG5001	Diguanylate cyclase
METD_RS12340	COG0297	glycogen (starch) synthase activity
METD_RS12345	COG0366	Alpha amylase catalytic
METD_RS12350	COG0058	SHG alpha-glucan phosphorylase activity
METD_RS12365	COG5001	Diguanylate cyclase
METD_RS12370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
METD_RS12375	COG0702	epimerase
METD_RS12380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
METD_RS12385	COG1733	regulation of RNA biosynthetic process
METD_RS12390	COG1086	Polysaccharide biosynthesis protein
METD_RS12445	COG1902	pentaerythritol trinitrate reductase activity
METD_RS12470	COG0416	fatty acid biosynthetic process
METD_RS12475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
METD_RS12480	COG0776	regulation of translation
METD_RS12500	COG2766	serine protein kinase
METD_RS12505	COG2718	Belongs to the UPF0229 family
METD_RS12510	COG2719	SpoVR family
METD_RS12515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
METD_RS12520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
METD_RS12530	COG0628	permease
METD_RS12540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
METD_RS12555	COG0436	Aminotransferase
METD_RS12570	COG0052	Belongs to the universal ribosomal protein uS2 family
METD_RS12575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
METD_RS12580	COG0528	UMP kinase activity
METD_RS12585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
METD_RS12605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
METD_RS12610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
METD_RS12615	COG0750	zinc metalloprotease
METD_RS12620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
METD_RS12630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
METD_RS12635	COG0233	cytoplasmic translational termination
METD_RS12645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
METD_RS12650	COG0583	DNA-binding transcription factor activity
METD_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS12660	COG3959	Transketolase, thiamine diphosphate binding domain
METD_RS12665	COG3958	Transketolase
METD_RS12670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
METD_RS12690	COG1946	Acyl-CoA thioesterase
METD_RS12695	COG0347	Belongs to the P(II) protein family
METD_RS12700	COG0004	ammonium transporteR
METD_RS12710	COG1674	ftsk spoiiie
METD_RS12720	COG3920	Histidine kinase
METD_RS12730	COG0243	molybdopterin cofactor binding
METD_RS12760	COG1045	serine acetyltransferase
METD_RS12765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
METD_RS12770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
METD_RS12770	COG4191	Histidine kinase
METD_RS12790	COG0784	Response regulator, receiver
METD_RS12790	COG3437	response regulator, receiver
METD_RS12825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
METD_RS12850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
METD_RS12870	COG1819	glycosyl
METD_RS12880	COG5001	Diguanylate cyclase
METD_RS12905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
METD_RS12910	COG0318	PFAM AMP-dependent synthetase and ligase
METD_RS12940	COG1942	4-Oxalocrotonate Tautomerase
METD_RS12955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
METD_RS12970	COG0583	DNA-binding transcription factor activity
METD_RS12975	COG0346	lactoylglutathione lyase activity
METD_RS12980	COG0400	carboxylic ester hydrolase activity
METD_RS12995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
METD_RS13000	COG0049	tRNA binding
METD_RS13005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
METD_RS13010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
METD_RS13015	COG0051	transcription antitermination factor activity, RNA binding
METD_RS13020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
METD_RS13025	COG0088	Forms part of the polypeptide exit tunnel
METD_RS13030	COG0089	rRNA binding
METD_RS13035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
METD_RS13040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
METD_RS13045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
METD_RS13050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
METD_RS13055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
METD_RS13060	COG0255	Belongs to the universal ribosomal protein uL29 family
METD_RS13065	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
METD_RS13070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS13080	COG1846	Transcriptional regulator
METD_RS13085	COG0203	ribosomal protein L17
METD_RS13100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
METD_RS13105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
METD_RS13110	COG0563	adenylate kinase activity
METD_RS13115	COG0201	protein transport
METD_RS13120	COG0200	Binds to the 23S rRNA
METD_RS13125	COG1841	ribosomal large subunit assembly
METD_RS13130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
METD_RS13135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
METD_RS13140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
METD_RS13145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
METD_RS13150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
METD_RS13155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
METD_RS13160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
METD_RS13165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
METD_RS13220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
METD_RS13235	COG3655	Transcriptional regulator
METD_RS13245	COG0024	Methionine aminopeptidase
METD_RS13250	COG2003	Belongs to the UPF0758 family
METD_RS13255	COG2308	Evidence 4 Homologs of previously reported genes of
METD_RS13295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
METD_RS13300	COG1253	flavin adenine dinucleotide binding
METD_RS13320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
METD_RS13350	COG3300	MHYT domain
METD_RS13350	COG5001	Diguanylate cyclase
METD_RS13380	COG0175	sulfate reduction
METD_RS13385	COG0175	sulfate reduction
METD_RS13390	COG1522	sequence-specific DNA binding
METD_RS13395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
METD_RS13400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
METD_RS13405	COG4774	siderophore transport
METD_RS13425	COG0629	single-stranded DNA binding
METD_RS13430	COG2130	NADP-dependent
METD_RS13445	COG3698	Phosphodiester glycosidase
METD_RS13450	COG1902	pentaerythritol trinitrate reductase activity
METD_RS13465	COG3118	belongs to the thioredoxin family
METD_RS13475	COG2835	tetraacyldisaccharide 4'-kinase activity
METD_RS13485	COG4191	Histidine kinase
METD_RS13485	COG0784	Response regulator, receiver
METD_RS13520	COG2239	Acts as a magnesium transporter
METD_RS13525	COG1752	Esterase of the alpha-beta hydrolase superfamily
METD_RS13530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
METD_RS13535	COG0302	gtp cyclohydrolase
METD_RS13545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
METD_RS13550	COG0670	Belongs to the BI1 family
METD_RS13560	COG4191	Histidine kinase
METD_RS13565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
METD_RS13575	COG0681	Belongs to the peptidase S26 family
METD_RS13580	COG0571	ribonuclease III activity
METD_RS13585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
METD_RS13595	COG1187	pseudouridine synthase activity
METD_RS13620	COG3158	transport of potassium into the cell
METD_RS13630	COG0494	nUDIX hydrolase
METD_RS13645	COG0793	Belongs to the peptidase S41A family
METD_RS13655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
METD_RS13665	COG5001	Diguanylate cyclase
METD_RS13665	COG3300	MHYT domain
METD_RS13675	COG0137	argininosuccinate synthase activity
METD_RS13690	COG0546	phosphoglycolate phosphatase activity
METD_RS13700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
METD_RS13725	COG2137	regulation of response to DNA damage stimulus
METD_RS13730	COG1764	response to oxidative stress
METD_RS13740	COG1573	uracil-dna glycosylase
METD_RS13770	COG0625	glutathione transferase activity
METD_RS13780	COG0753	catalase activity
METD_RS13790	COG0778	Nitroreductase
METD_RS13805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
METD_RS13810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
METD_RS13820	COG1940	carbohydrate kinase activity
METD_RS13825	COG1301	dicarboxylic acid transport
METD_RS13830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
METD_RS13835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
METD_RS13845	COG0612	Peptidase, M16
METD_RS13850	COG0612	Peptidase, M16
METD_RS13855	COG0346	lactoylglutathione lyase activity
METD_RS13865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
METD_RS13915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
METD_RS13940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
METD_RS13945	COG2031	fatty acid transporter
METD_RS13955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
METD_RS13960	COG0706	membrane insertase activity
METD_RS13965	COG0594	ribonuclease P activity
METD_RS13970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
METD_RS13980	COG0254	rRNA binding
METD_RS13985	COG1132	(ABC) transporter
METD_RS13990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
METD_RS14005	COG1692	metallophosphoesterase
METD_RS14010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
METD_RS14035	COG0126	phosphoglycerate kinase activity
METD_RS14055	COG0531	amino acid
METD_RS14060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
METD_RS14060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
METD_RS14065	COG0347	Belongs to the P(II) protein family
METD_RS14070	COG2066	Belongs to the glutaminase family
METD_RS14075	COG0174	glutamine synthetase
METD_RS14080	COG0174	glutamine synthetase
METD_RS14085	COG0431	NADPH-dependent FMN reductase
METD_RS14095	COG0557	exoribonuclease II activity
METD_RS14120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
METD_RS14130	COG1968	undecaprenyl-diphosphatase activity
METD_RS14155	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
METD_RS14160	COG1088	dTDP-glucose 4,6-dehydratase activity
METD_RS14165	COG1091	dTDP-4-dehydrorhamnose reductase activity
METD_RS14175	COG3161	chorismate lyase activity
METD_RS14180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS14185	COG0653	protein targeting
METD_RS14210	COG0544	peptidyl-prolyl cis-trans isomerase activity
METD_RS14215	COG0740	serine-type endopeptidase activity
METD_RS14220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
METD_RS14225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
METD_RS14240	COG0438	transferase activity, transferring glycosyl groups
METD_RS14250	COG2813	Specifically methylates the guanine in position
METD_RS14260	COG3665	Urea carboxylase-associated protein
METD_RS14265	COG1297	OPT oligopeptide transporter protein
METD_RS14285	COG1295	ribonuclease BN
METD_RS14300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
METD_RS14300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
METD_RS14305	COG1515	deoxyribonuclease V activity
METD_RS14310	COG0012	GTP binding
METD_RS14315	COG0193	aminoacyl-tRNA hydrolase activity
METD_RS14320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
METD_RS14345	COG4964	Belongs to the GSP D family
METD_RS14380	COG0477	Major facilitator Superfamily
METD_RS14385	COG1764	response to oxidative stress
METD_RS14390	COG1832	CoA-binding protein
METD_RS14405	COG2203	Gaf domain
METD_RS14405	COG5001	Diguanylate cyclase
METD_RS14405	COG4251	negative regulation of phosphorylation
METD_RS14405	COG3706	GGDEF domain
METD_RS14430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
METD_RS14445	COG1137	ATPase activity
METD_RS14450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
METD_RS14455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
METD_RS14460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
METD_RS14475	COG0588	phosphoglycerate mutase activity
METD_RS14480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
METD_RS14495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS14505	COG4974	Belongs to the 'phage' integrase family
METD_RS14520	COG4239	(ABC) transporter, permease
METD_RS14530	COG0436	Aminotransferase
METD_RS14540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS14560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
METD_RS14565	COG0473	3-isopropylmalate dehydrogenase activity
METD_RS14585	COG3011	Protein conserved in bacteria
METD_RS14595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
METD_RS14600	COG0415	Belongs to the DNA photolyase family
METD_RS14605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
METD_RS14625	COG1368	sulfuric ester hydrolase activity
METD_RS14645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
METD_RS14655	COG0723	plastoquinol--plastocyanin reductase activity
METD_RS14660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
METD_RS14660	COG2857	Cytochrome c1
METD_RS14665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
METD_RS14665	COG2857	Cytochrome c1
METD_RS14670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
METD_RS14695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
METD_RS14700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
METD_RS14710	COG0140	phosphoribosyl-ATP diphosphatase activity
METD_RS14715	COG1072	(Pantothenic acid kinase))
METD_RS14735	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS14735	COG1388	LysM domain
METD_RS14755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
METD_RS14760	COG3162	membrane
METD_RS14775	COG0138	bifunctional purine biosynthesis protein purh
METD_RS14785	COG2897	thiosulfate sulfurtransferase activity
METD_RS14800	COG0513	Belongs to the DEAD box helicase family
METD_RS14820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS14835	COG1970	mechanosensitive ion channel activity
METD_RS14850	COG0436	Aminotransferase
METD_RS14865	COG0745	RESPONSE REGULATOR receiver
METD_RS14870	COG1846	Transcriptional regulator
METD_RS14875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
METD_RS14900	COG0475	glutathione-regulated potassium exporter activity
METD_RS14900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
METD_RS14905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
METD_RS14910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
METD_RS14920	COG1678	Uncharacterized ACR, COG1678
METD_RS14930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
METD_RS14935	COG2378	regulation of single-species biofilm formation
METD_RS14940	COG0625	glutathione transferase activity
METD_RS14945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
METD_RS14960	COG1684	flagellar biosynthetic protein fliR
METD_RS14965	COG1987	bacterial-type flagellum assembly
METD_RS14970	COG1677	Flagellar hook-basal body complex protein FliE
METD_RS14975	COG1558	bacterial-type flagellum-dependent cell motility
METD_RS14980	COG1815	bacterial-type flagellum-dependent cell motility
METD_RS14990	COG0579	oxidoreductase
METD_RS15000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
METD_RS15010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
METD_RS15015	COG0247	lactate metabolic process
METD_RS15020	COG1139	Iron-sulfur cluster binding protein
METD_RS15035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
METD_RS15040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
METD_RS15060	COG1132	(ABC) transporter
METD_RS15085	COG0424	maF-like protein
METD_RS15190	COG4774	siderophore transport
METD_RS15205	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
METD_RS15210	COG4133	protoheme IX ABC transporter activity
METD_RS15220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
METD_RS15230	COG0625	glutathione transferase activity
METD_RS15235	COG1252	NADH dehydrogenase
METD_RS15250	COG0840	transmembrane signaling receptor activity
METD_RS15260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
METD_RS15270	COG1388	LysM domain
METD_RS15270	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS15305	COG2084	Dehydrogenase
METD_RS15310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
METD_RS15315	COG0560	Phosphoserine phosphatase
METD_RS15325	COG0330	HflC and HflK could
METD_RS15330	COG0330	HflC and HflK could
METD_RS15355	COG2124	cytochrome p450
METD_RS15360	COG0114	fumarate hydratase activity
METD_RS15380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
METD_RS15385	COG0586	Pfam SNARE associated Golgi protein
METD_RS15390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
METD_RS15395	COG0384	phenazine biosynthesis protein PhzF
METD_RS15410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
METD_RS15415	COG0129	dihydroxy-acid dehydratase activity
METD_RS15425	COG4948	Mandelate Racemase Muconate Lactonizing
METD_RS15450	COG0673	inositol 2-dehydrogenase activity
METD_RS15465	COG0438	transferase activity, transferring glycosyl groups
METD_RS15480	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
METD_RS15480	COG0392	lysyltransferase activity
METD_RS15485	COG5002	protein histidine kinase activity
METD_RS15495	COG0789	Transcriptional regulator
METD_RS15500	COG1473	amidohydrolase
METD_RS15510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
METD_RS15520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
METD_RS15525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
METD_RS15530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
METD_RS15545	COG0779	Required for maturation of 30S ribosomal subunits
METD_RS15550	COG0110	maltose O-acetyltransferase activity
METD_RS15555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
METD_RS15570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
METD_RS15580	COG0523	cobalamin synthesis protein
METD_RS15585	COG1309	transcriptional regulator
METD_RS15595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
METD_RS15605	COG0366	Alpha amylase catalytic
METD_RS15610	COG0366	Alpha amylase catalytic
METD_RS15615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
METD_RS15620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
METD_RS15645	COG1742	UPF0060 membrane protein
METD_RS15650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
METD_RS15665	COG0552	protein localization to endoplasmic reticulum
METD_RS15685	COG0142	geranyltranstransferase activity
METD_RS15690	COG0500	methyltransferase
METD_RS15695	COG1063	alcohol dehydrogenase
METD_RS15700	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
METD_RS15705	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
METD_RS15710	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
METD_RS15745	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
METD_RS15750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS15755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
METD_RS15765	COG2267	carboxylic ester hydrolase activity
METD_RS15770	COG0469	pyruvate kinase activity
METD_RS15800	COG3750	Belongs to the UPF0335 family
METD_RS15815	COG2204	response regulator
METD_RS15835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
METD_RS15900	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
METD_RS15905	COG3604	Transcriptional regulator
METD_RS15915	COG1858	cytochrome C peroxidase
METD_RS15925	COG3300	MHYT domain
METD_RS15925	COG5001	Diguanylate cyclase
METD_RS15930	COG3546	catalase activity
METD_RS15965	COG2877	3-deoxy-8-phosphooctulonate synthase activity
METD_RS15975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
METD_RS15980	COG0148	phosphopyruvate hydratase activity
METD_RS15985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
METD_RS15990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
METD_RS15995	COG0508	dehydrogenase complex catalyzes the overall conversion of
METD_RS15995	COG0022	dehydrogenase e1 component
METD_RS16005	COG0508	dehydrogenase complex catalyzes the overall conversion of
METD_RS16010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
METD_RS16055	COG2867	negative regulation of translational initiation
METD_RS16065	COG2423	ornithine cyclodeaminase activity
METD_RS16070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
METD_RS16080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
METD_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS16090	COG4638	Rieske (2fe-2S)
METD_RS16095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
METD_RS16110	COG5265	(ABC) transporter
METD_RS16115	COG2080	2 iron, 2 sulfur cluster binding
METD_RS16120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
METD_RS16125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS16130	COG1546	Belongs to the CinA family
METD_RS16130	COG1058	Belongs to the CinA family
METD_RS16135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
METD_RS16135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
METD_RS16140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
METD_RS16150	COG2204	response regulator
METD_RS16155	COG1061	Type III restriction enzyme res subunit
METD_RS16160	COG5000	phosphorelay sensor kinase activity
METD_RS16165	COG2204	response regulator
METD_RS16170	COG1923	regulation of RNA biosynthetic process
METD_RS16175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
METD_RS16180	COG0659	secondary active sulfate transmembrane transporter activity
METD_RS16220	COG4957	zinc ion binding
METD_RS16280	COG0303	'Molybdopterin
METD_RS16285	COG1763	Mo-molybdopterin cofactor biosynthetic process
METD_RS16290	COG0303	'Molybdopterin
METD_RS16300	COG4662	Binding-protein-dependent transport system inner membrane component
METD_RS16325	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
METD_RS16330	COG2943	transferase activity, transferring hexosyl groups
METD_RS16345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
METD_RS16350	COG2204	response regulator
METD_RS16355	COG0037	tRNA processing
METD_RS16355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
METD_RS16365	COG2884	Cell division ATP-binding protein ftsE
METD_RS16385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
METD_RS16390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
METD_RS16395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
METD_RS16400	COG0799	negative regulation of ribosome biogenesis
METD_RS16420	COG1132	(ABC) transporter
METD_RS16430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
METD_RS16435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
METD_RS16440	COG0322	excinuclease ABC activity
METD_RS16450	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS16460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
METD_RS16465	COG1496	oxidoreductase activity
METD_RS16475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
METD_RS16480	COG1285	pathogenesis
METD_RS16485	COG0033	Phosphoglucomutase
METD_RS16505	COG0574	Belongs to the PEP-utilizing enzyme family
METD_RS16505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
METD_RS16510	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS16515	COG0346	lactoylglutathione lyase activity
METD_RS16525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS16525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
METD_RS16545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS16565	COG0784	Response regulator, receiver
METD_RS16580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
METD_RS16590	COG1408	metallophosphoesterase
METD_RS16615	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
METD_RS16625	COG1686	Belongs to the peptidase S11 family
METD_RS16670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
METD_RS16675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
METD_RS16695	COG0519	Catalyzes the synthesis of GMP from XMP
METD_RS16695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
METD_RS16710	COG0657	acetylesterase activity
METD_RS16710	COG2755	lipolytic protein G-D-S-L family
METD_RS16725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
METD_RS16755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
METD_RS16775	COG1181	Belongs to the D-alanine--D-alanine ligase family
METD_RS16780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
METD_RS16785	COG0849	cell division
METD_RS16790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
METD_RS16800	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
METD_RS16830	COG0243	molybdopterin cofactor binding
METD_RS16845	COG0484	heat shock protein binding
METD_RS16850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
METD_RS16865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
METD_RS16875	COG0295	cytidine deaminase activity
METD_RS16885	COG1663	tetraacyldisaccharide 4'-kinase activity
METD_RS16890	COG1519	Transferase
METD_RS16910	COG1278	Cold shock
METD_RS16920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
METD_RS16930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
METD_RS16955	COG0741	lytic transglycosylase activity
METD_RS16955	COG0739	heme binding
METD_RS16955	COG1196	nuclear chromosome segregation
METD_RS16960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
METD_RS16970	COG3239	Fatty acid desaturase
METD_RS16975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
METD_RS16990	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
METD_RS17000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
METD_RS17000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
METD_RS17010	COG0123	including yeast histone deacetylase and acetoin utilization protein
METD_RS17015	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS17025	COG4770	biotin carboxylase activity
METD_RS17040	COG1254	Belongs to the acylphosphatase family
METD_RS17060	COG0625	glutathione transferase activity
METD_RS17065	COG1509	lysine 2,3-aminomutase activity
METD_RS17070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
METD_RS17085	COG1278	Cold shock
METD_RS17095	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
METD_RS17105	COG1233	COG1233 Phytoene dehydrogenase and related
METD_RS17110	COG1562	ergosterol biosynthetic process
METD_RS17115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
METD_RS17120	COG0830	nickel cation binding
METD_RS17125	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
METD_RS17135	COG0804	urea catabolic process
METD_RS17140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
METD_RS17145	COG0832	Belongs to the urease beta subunit family
METD_RS17145	COG0831	urea catabolic process
METD_RS17150	COG0829	nickel cation binding
METD_RS17155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
METD_RS17165	COG2351	hydroxyisourate hydrolase activity
METD_RS17185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS17190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
METD_RS17210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
METD_RS17220	COG2900	Belongs to the SlyX family
METD_RS17245	COG1696	Membrane protein involved in D-alanine export
METD_RS17260	COG1706	bacterial-type flagellum-dependent cell motility
METD_RS17275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
METD_RS17285	COG4786	Flagellar basal body rod
METD_RS17290	COG4786	Flagellar basal body rod
METD_RS17315	COG0386	Belongs to the glutathione peroxidase family
METD_RS17325	COG2951	lytic endotransglycosylase activity
METD_RS17330	COG2249	NAD(P)H dehydrogenase (quinone) activity
METD_RS17335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
METD_RS17345	COG1301	dicarboxylic acid transport
METD_RS17350	COG4191	Histidine kinase
METD_RS17355	COG2204	response regulator
METD_RS17360	COG3706	GGDEF domain
METD_RS17365	COG5001	Diguanylate cyclase
METD_RS17365	COG3300	MHYT domain
METD_RS17405	COG0343	queuine tRNA-ribosyltransferase activity
METD_RS17435	COG2954	triphosphatase activity
METD_RS17445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
METD_RS17480	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
METD_RS17495	COG0436	Aminotransferase
METD_RS17510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
METD_RS17510	COG4651	solute:proton antiporter activity
METD_RS17535	COG0752	glycyl-tRNA synthetase alpha subunit
METD_RS17545	COG1309	transcriptional regulator
METD_RS17565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
METD_RS17575	COG0142	geranyltranstransferase activity
METD_RS17655	COG0187	DNA topoisomerase II activity
METD_RS17670	COG1132	(ABC) transporter
METD_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS17705	COG2814	Major facilitator Superfamily
METD_RS17710	COG2267	carboxylic ester hydrolase activity
METD_RS17720	COG0625	glutathione transferase activity
METD_RS17740	COG0590	tRNA wobble adenosine to inosine editing
METD_RS17760	COG4191	Histidine kinase
METD_RS17760	COG0784	Response regulator, receiver
METD_RS17770	COG0538	isocitrate dehydrogenase activity
METD_RS17785	COG3609	addiction module antidote protein, CC2985 family
METD_RS17820	COG2972	Histidine kinase
METD_RS17820	COG0840	transmembrane signaling receptor activity
METD_RS17830	COG2873	o-acetylhomoserine
METD_RS17840	COG0247	lactate metabolic process
METD_RS17850	COG0657	acetylesterase activity
METD_RS17855	COG1201	RNA secondary structure unwinding
METD_RS17875	COG5487	UPF0391 membrane protein
METD_RS17880	COG4221	oxidoreductase activity
METD_RS17885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
METD_RS17890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
METD_RS17895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
METD_RS17900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
METD_RS17900	COG0546	phosphoglycolate phosphatase activity
METD_RS17925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
METD_RS17925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
METD_RS17940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
METD_RS17945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
METD_RS17950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
METD_RS17960	COG0356	it plays a direct role in the translocation of protons across the membrane
METD_RS17970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
METD_RS17985	COG2189	Belongs to the N(4) N(6)-methyltransferase family
METD_RS17990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
METD_RS18005	COG0488	(ABC) transporter
METD_RS18030	COG0741	lytic transglycosylase activity
METD_RS18035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
METD_RS18040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
METD_RS18050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
METD_RS18065	COG1758	RNA polymerase activity
METD_RS18070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
METD_RS18075	COG1214	PFAM Peptidase M22, glycoprotease
METD_RS18095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
METD_RS18100	COG1702	phosphate starvation-inducible protein PhoH
METD_RS18105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
METD_RS18110	COG1253	flavin adenine dinucleotide binding
METD_RS18115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
METD_RS18125	COG0753	catalase activity
METD_RS18135	COG3180	Ammonia monooxygenase
METD_RS18160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
METD_RS18165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
METD_RS18170	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
METD_RS18185	COG0243	molybdopterin cofactor binding
METD_RS18190	COG1648	precorrin-2 dehydrogenase activity
METD_RS18190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
METD_RS18195	COG1999	signal sequence binding
METD_RS18260	COG1793	dna ligase
METD_RS18265	COG0432	Pfam Uncharacterised protein family UPF0047
METD_RS18270	COG0432	Pfam Uncharacterised protein family UPF0047
METD_RS18285	COG1024	Enoyl-CoA hydratase
METD_RS18285	COG1250	3-hydroxyacyl-CoA dehydrogenase
METD_RS18300	COG0183	Belongs to the thiolase family
METD_RS18305	COG1960	acyl-CoA dehydrogenase activity
METD_RS18330	COG0671	phosphoesterase, PA-phosphatase related
METD_RS18335	COG0673	inositol 2-dehydrogenase activity
METD_RS18340	COG0612	Peptidase, M16
METD_RS18355	COG3346	SURF1 family
METD_RS18370	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
METD_RS18385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
METD_RS18395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
METD_RS18405	COG0067	glutamate synthase
METD_RS18405	COG0070	glutamate synthase
METD_RS18405	COG0069	glutamate synthase activity
METD_RS18425	COG4585	Histidine kinase
METD_RS18440	COG2951	lytic endotransglycosylase activity
METD_RS18450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
METD_RS18470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
METD_RS18480	COG0784	Response regulator, receiver
METD_RS18480	COG4191	Histidine kinase
METD_RS18485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
METD_RS18490	COG2862	Uncharacterized protein family, UPF0114
METD_RS18515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
METD_RS18540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
METD_RS18560	COG0728	peptidoglycan biosynthetic process
METD_RS18565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
METD_RS18575	COG3920	Histidine kinase
METD_RS18590	COG4783	chaperone-mediated protein folding
METD_RS18600	COG1396	sequence-specific DNA binding
METD_RS18605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
METD_RS18610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
METD_RS18615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
METD_RS18620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
METD_RS18625	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
METD_RS18635	COG0540	Belongs to the ATCase OTCase family
METD_RS18645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
METD_RS18650	COG0758	DNA mediated transformation
METD_RS18670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
METD_RS18685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
METD_RS18710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS18720	COG1376	ErfK ybiS ycfS ynhG family protein
METD_RS18740	COG5425	PFAM Usg family protein
METD_RS18745	COG0459	protein refolding
METD_RS18750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
METD_RS18780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS18785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
METD_RS18790	COG2233	PERMEase
METD_RS18805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS18815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS18845	COG5001	Diguanylate cyclase
METD_RS18845	COG3300	MHYT domain
METD_RS18855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
METD_RS18890	COG4191	Histidine kinase
METD_RS18890	COG0784	Response regulator, receiver
METD_RS18915	COG0559	Belongs to the binding-protein-dependent transport system permease family
METD_RS18930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
METD_RS18940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
METD_RS18960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
METD_RS18970	COG0411	ABC transporter
METD_RS18990	COG0784	Response regulator, receiver
METD_RS18990	COG2198	Histidine kinase
METD_RS18990	COG5002	protein histidine kinase activity
METD_RS19040	COG0316	Belongs to the HesB IscA family
METD_RS19045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
METD_RS19080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
METD_RS19085	COG0805	protein transport
METD_RS19095	COG2814	Major facilitator Superfamily
METD_RS19105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS19110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS19115	COG1116	anion transmembrane transporter activity
METD_RS19125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS19130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS19170	COG1309	transcriptional regulator
METD_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS19180	COG2814	Major facilitator Superfamily
METD_RS19195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
METD_RS19200	COG1012	belongs to the aldehyde dehydrogenase family
METD_RS19215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
METD_RS19225	COG2259	Doxx family
METD_RS19230	COG0477	Major facilitator Superfamily
METD_RS19240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
METD_RS19245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
METD_RS19280	COG1131	(ABC) transporter
METD_RS19305	COG2030	dehydratase
METD_RS19330	COG0625	glutathione transferase activity
METD_RS19365	COG3394	polysaccharide catabolic process
METD_RS19395	COG3265	gluconokinase activity
METD_RS19410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
METD_RS19440	COG2309	aminopeptidase activity
METD_RS19450	COG0277	FAD linked oxidase domain protein
METD_RS19515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS19610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS19615	COG4566	intracellular signal transduction
METD_RS19620	COG4191	Histidine kinase
METD_RS19675	COG1525	nuclease
METD_RS19695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
METD_RS19700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
METD_RS19730	COG1396	sequence-specific DNA binding
METD_RS19930	COG2801	Transposase and inactivated derivatives
METD_RS19970	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS19975	COG0604	alcohol dehydrogenase
METD_RS19985	COG1733	regulation of RNA biosynthetic process
METD_RS19995	COG0683	leucine binding
METD_RS20010	COG3842	ATPase activity
METD_RS20015	COG0831	urea catabolic process
METD_RS20015	COG0832	Belongs to the urease beta subunit family
METD_RS20020	COG0804	urea catabolic process
METD_RS20025	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
METD_RS20030	COG0829	nickel cation binding
METD_RS20095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
METD_RS20180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
METD_RS20195	COG0488	(ABC) transporter
METD_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS20245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS20275	COG1289	transmembrane transporter activity
METD_RS20285	COG1566	PFAM secretion protein HlyD family protein
METD_RS20290	COG2514	catechol 2,3-dioxygenase activity
METD_RS20300	COG2860	membrane
METD_RS20310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
METD_RS20330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
METD_RS20340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
METD_RS20345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
METD_RS20350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
METD_RS20360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
METD_RS20360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
METD_RS20375	COG0626	cystathionine gamma-synthase activity
METD_RS20380	COG1959	2 iron, 2 sulfur cluster binding
METD_RS20395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
METD_RS20415	COG4957	zinc ion binding
METD_RS20420	COG3750	Belongs to the UPF0335 family
METD_RS20435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
METD_RS20440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
METD_RS20445	COG2010	Cytochrome c
METD_RS20445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS20455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS20480	COG2801	Transposase and inactivated derivatives
METD_RS20490	COG0659	secondary active sulfate transmembrane transporter activity
METD_RS20495	COG0123	including yeast histone deacetylase and acetoin utilization protein
METD_RS20500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS20505	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS20610	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
METD_RS20615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
METD_RS20625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
METD_RS20645	COG0280	phosphate acetyltransferase
METD_RS20660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
METD_RS20670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS20685	COG0745	RESPONSE REGULATOR receiver
METD_RS20690	COG4566	intracellular signal transduction
METD_RS20695	COG4191	Histidine kinase
METD_RS20745	COG3547	Transposase (IS116 IS110 IS902 family)
METD_RS20835	COG1914	H( )-stimulated, divalent metal cation uptake system
METD_RS20900	COG1024	Enoyl-CoA hydratase
METD_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS20915	COG0598	Magnesium transport protein CorA
METD_RS20920	COG3685	Protein conserved in bacteria
METD_RS20955	COG4191	Histidine kinase
METD_RS20955	COG0784	Response regulator, receiver
METD_RS20980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
METD_RS21015	COG4149	molybdate abc transporter
METD_RS21030	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
METD_RS21040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
METD_RS21045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
METD_RS21065	COG0659	secondary active sulfate transmembrane transporter activity
METD_RS21115	COG0318	PFAM AMP-dependent synthetase and ligase
METD_RS21145	COG0436	Aminotransferase
METD_RS21155	COG1530	ribonuclease E activity
METD_RS21155	COG1530	ribonuclease E activity
METD_RS21165	COG0860	N-Acetylmuramoyl-L-alanine amidase
METD_RS21170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
METD_RS21185	COG2080	2 iron, 2 sulfur cluster binding
METD_RS21190	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
METD_RS21195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
METD_RS21205	COG2252	PERMEase
METD_RS21215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
METD_RS21240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
METD_RS21285	COG4770	biotin carboxylase activity
METD_RS21290	COG3665	Urea carboxylase-associated protein
METD_RS21295	COG3665	Urea carboxylase-associated protein
METD_RS21315	COG1116	anion transmembrane transporter activity
METD_RS21320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS21330	COG4175	Glycine betaine
METD_RS21330	COG0517	IMP dehydrogenase activity
METD_RS21355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
METD_RS21365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
METD_RS21365	COG0446	pyridine nucleotide-disulphide oxidoreductase
METD_RS21375	COG1760	l-serine dehydratase
METD_RS21400	COG0247	lactate metabolic process
METD_RS21400	COG2181	nitrate reductase activity
METD_RS21405	COG0446	pyridine nucleotide-disulphide oxidoreductase
METD_RS21405	COG1902	pentaerythritol trinitrate reductase activity
METD_RS21415	COG4638	Rieske (2fe-2S)
METD_RS21435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
METD_RS21440	COG4172	Belongs to the ABC transporter superfamily
METD_RS21450	COG0601	transmembrane transport
METD_RS21490	COG1082	Xylose isomerase domain protein TIM barrel
METD_RS21500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
METD_RS21540	COG3706	GGDEF domain
METD_RS21555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
METD_RS21575	COG2030	dehydratase
METD_RS21605	COG4957	zinc ion binding
METD_RS21630	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS21655	COG1309	transcriptional regulator
METD_RS21660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS21675	COG0583	DNA-binding transcription factor activity
METD_RS21680	COG0667	Aldo Keto reductase
METD_RS21685	COG3447	MASE1 domain protein
METD_RS21685	COG5002	protein histidine kinase activity
METD_RS21685	COG5001	Diguanylate cyclase
METD_RS21735	COG0628	permease
METD_RS21740	COG3920	Histidine kinase
METD_RS21790	COG0583	DNA-binding transcription factor activity
METD_RS21850	COG1294	oxidase, subunit
METD_RS21855	COG1271	oxidase subunit
METD_RS21865	COG0640	Transcriptional regulator
METD_RS21875	COG0450	alkyl hydroperoxide reductase
METD_RS21890	COG0596	Alpha beta hydrolase
METD_RS21895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
METD_RS21900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
METD_RS21905	COG1120	ATPase activity
METD_RS21910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
METD_RS21945	COG0667	Aldo Keto reductase
METD_RS21955	COG1335	isochorismatase
METD_RS21965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS21980	COG0656	L-ascorbic acid biosynthetic process
METD_RS21985	COG0742	ribosomal rna small subunit methyltransferase
METD_RS22000	COG0431	NADPH-dependent FMN reductase
METD_RS22015	COG0798	PFAM Bile acid sodium symporter
METD_RS22020	COG5001	Diguanylate cyclase
METD_RS22025	COG0596	Alpha beta hydrolase
METD_RS22035	COG0590	tRNA wobble adenosine to inosine editing
METD_RS22040	COG0151	Belongs to the GarS family
METD_RS22055	COG1570	exodeoxyribonuclease VII activity
METD_RS22075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
METD_RS22080	COG0604	alcohol dehydrogenase
METD_RS22120	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
METD_RS22130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
METD_RS22135	COG1595	DNA-templated transcription, initiation
METD_RS22200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
METD_RS22220	COG1335	isochorismatase
METD_RS22225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
METD_RS22250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
METD_RS22270	COG3956	TIGRFAM MazG family protein
METD_RS22290	COG2301	Belongs to the HpcH HpaI aldolase family
METD_RS22300	COG3706	GGDEF domain
METD_RS22320	COG2199	diguanylate cyclase activity
METD_RS22320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
METD_RS22355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
METD_RS22360	COG2226	methyltransferase
METD_RS22365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
METD_RS22370	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS22375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
METD_RS22385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS22390	COG1999	signal sequence binding
METD_RS22400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
METD_RS22410	COG0359	binds to the 23S rRNA
METD_RS22420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
METD_RS22425	COG0360	Binds together with S18 to 16S ribosomal RNA
METD_RS22450	COG1278	Cold shock
METD_RS22460	COG0242	peptide deformylase activity
METD_RS22490	COG2610	gluconate transmembrane transporter activity
METD_RS22495	COG1301	dicarboxylic acid transport
METD_RS22525	COG0765	amino acid transport
METD_RS22530	COG0765	amino acid transport
METD_RS22535	COG1126	abc transporter atp-binding protein
METD_RS22545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
METD_RS22590	COG2945	thiolester hydrolase activity
METD_RS22600	COG0719	Fe-S assembly protein
METD_RS22605	COG0396	ATPase activity
METD_RS22610	COG0719	Fe-S assembly protein
METD_RS22615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
METD_RS22630	COG0316	Belongs to the HesB IscA family
METD_RS22635	COG3706	GGDEF domain
METD_RS22635	COG4251	negative regulation of phosphorylation
METD_RS22635	COG5001	Diguanylate cyclase
METD_RS22635	COG2203	Gaf domain
METD_RS22640	COG0513	Belongs to the DEAD box helicase family
METD_RS22650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
METD_RS22690	COG4181	ATPase activity
METD_RS22700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
METD_RS22715	COG0250	Participates in transcription elongation, termination and antitermination
METD_RS22720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
METD_RS22725	COG0081	regulation of translation
METD_RS22730	COG2124	cytochrome p450
METD_RS22735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
METD_RS22760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
METD_RS22780	COG0287	Prephenate dehydrogenase
METD_RS22785	COG5001	Diguanylate cyclase
METD_RS22785	COG3300	MHYT domain
METD_RS22805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
METD_RS22810	COG0222	ribosome binding
METD_RS22815	COG0085	RNA polymerase activity
METD_RS22820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
METD_RS22830	COG0251	oxidation-reduction process
METD_RS22835	COG2261	transglycosylase associated protein
METD_RS22855	COG4774	siderophore transport
METD_RS22860	COG1185	polyribonucleotide nucleotidyltransferase activity
METD_RS22865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
METD_RS22870	COG0531	amino acid
METD_RS22885	COG5001	Diguanylate cyclase
METD_RS22895	COG1674	ftsk spoiiie
METD_RS22905	COG0784	Response regulator, receiver
METD_RS22915	COG2807	transmembrane transport
METD_RS22945	COG0730	response to heat
METD_RS22950	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
METD_RS22955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
METD_RS22965	COG1959	2 iron, 2 sulfur cluster binding
METD_RS22970	COG3634	alkyl hydroperoxide reductase activity
METD_RS22975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
METD_RS22980	COG0784	Response regulator, receiver
METD_RS22980	COG4191	Histidine kinase
METD_RS22990	COG3753	Protein conserved in bacteria
METD_RS23000	COG0556	nucleotide-excision repair
METD_RS23015	COG0583	DNA-binding transcription factor activity
METD_RS23025	COG2514	catechol 2,3-dioxygenase activity
METD_RS23040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
METD_RS23045	COG1032	radical SAM domain protein
METD_RS23060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
METD_RS23100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
METD_RS23105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
METD_RS23125	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS23135	COG4251	negative regulation of phosphorylation
METD_RS23170	COG2204	response regulator
METD_RS23175	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
METD_RS23185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
METD_RS23190	COG1766	The M ring may be actively involved in energy transduction
METD_RS23210	COG0482	sulfurtransferase activity
METD_RS23220	COG0398	Pfam SNARE associated Golgi protein
METD_RS23230	COG0288	reversible hydration of carbon dioxide
METD_RS23250	COG1960	acyl-CoA dehydrogenase activity
METD_RS23255	COG0009	L-threonylcarbamoyladenylate synthase
METD_RS23260	COG0784	Response regulator, receiver
METD_RS23260	COG4191	Histidine kinase
METD_RS23270	COG4251	negative regulation of phosphorylation
METD_RS23275	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
METD_RS23285	COG0784	Response regulator, receiver
METD_RS23285	COG4191	Histidine kinase
METD_RS23330	COG4774	siderophore transport
METD_RS23350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
METD_RS23370	COG3206	protein involved in exopolysaccharide biosynthesis
METD_RS23370	COG0489	protein tyrosine kinase activity
METD_RS23380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS23390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS23395	COG1596	polysaccharide export
METD_RS23400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
METD_RS23400	COG0662	Cupin 2, conserved barrel domain protein
METD_RS23455	COG0714	Associated with various cellular activities
METD_RS23465	COG2010	Cytochrome c
METD_RS23470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
METD_RS23475	COG4993	Dehydrogenase
METD_RS23495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
METD_RS23510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
METD_RS23515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
METD_RS23535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
METD_RS23545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
METD_RS23550	COG1278	Cold shock
METD_RS23580	COG4191	Histidine kinase
METD_RS23580	COG0784	Response regulator, receiver
METD_RS23590	COG0318	PFAM AMP-dependent synthetase and ligase
METD_RS23600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
METD_RS23605	COG0463	Glycosyl transferase, family 2
METD_RS23620	COG2072	flavoprotein involved in K transport
METD_RS23635	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
METD_RS23655	COG3920	Histidine kinase
METD_RS23675	COG0084	hydrolase, TatD family'
METD_RS23700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
METD_RS23705	COG1177	transmembrane transport
METD_RS23710	COG1176	ABC-type spermidine putrescine transport system, permease component I
METD_RS23715	COG3842	ATPase activity
METD_RS23740	COG2271	Major facilitator Superfamily
METD_RS23745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
METD_RS23755	COG3622	Belongs to the hyi family
METD_RS23760	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS23765	COG0247	lactate metabolic process
METD_RS23805	COG0321	lipoyl(octanoyl) transferase activity
METD_RS23825	COG0745	RESPONSE REGULATOR receiver
METD_RS23845	COG0697	spore germination
METD_RS23865	COG1620	l-lactate permease
METD_RS23870	COG3546	catalase activity
METD_RS23880	COG3737	Protein of unknown function (DUF498/DUF598)
METD_RS23890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
METD_RS23895	COG1862	Preprotein translocase
METD_RS23910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
METD_RS23915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
METD_RS23935	COG1846	Transcriptional regulator
METD_RS23945	COG1024	Enoyl-CoA hydratase
METD_RS23950	COG0113	porphobilinogen synthase activity
METD_RS23980	COG0110	maltose O-acetyltransferase activity
METD_RS23985	COG2321	neutral zinc metallopeptidase
METD_RS23990	COG1573	uracil-dna glycosylase
METD_RS24000	COG3191	aminopeptidase activity
METD_RS24020	COG0626	cystathionine gamma-synthase activity
METD_RS24040	COG0259	pyridoxamine-phosphate oxidase activity
METD_RS24050	COG0438	transferase activity, transferring glycosyl groups
METD_RS24050	COG1216	Glycosyl transferase, family 2
METD_RS24060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
METD_RS24065	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS24075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
METD_RS24085	COG0488	(ABC) transporter
METD_RS24110	COG4166	transmembrane transport
METD_RS24115	COG0601	transmembrane transport
METD_RS24120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
METD_RS24130	COG0477	Major facilitator Superfamily
METD_RS24150	COG0655	NAD(P)H dehydrogenase (quinone) activity
METD_RS24160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
METD_RS24170	COG1643	Atp-dependent helicase
METD_RS24190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
METD_RS24200	COG2326	polyphosphate kinase activity
METD_RS24210	COG2258	MOSC domain
METD_RS24215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
METD_RS24220	COG0484	heat shock protein binding
METD_RS24230	COG0259	pyridoxamine-phosphate oxidase activity
METD_RS24240	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS24270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
METD_RS24280	COG2818	Glycosylase
METD_RS24285	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
METD_RS24295	COG1722	exodeoxyribonuclease VII activity
METD_RS24300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
METD_RS24305	COG2032	superoxide dismutase activity
METD_RS24310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
METD_RS24315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
METD_RS24340	COG1473	amidohydrolase
METD_RS24345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
METD_RS24345	COG2169	Transcriptional regulator
METD_RS24355	COG0537	adenosine 5'-monophosphoramidase activity
METD_RS24370	COG3387	PFAM Glycoside hydrolase 15-related
METD_RS24380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
METD_RS24385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
METD_RS24390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
METD_RS24400	COG0252	asparaginase activity
METD_RS24410	COG0398	Pfam SNARE associated Golgi protein
METD_RS24425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
METD_RS24430	COG1845	cytochrome c oxidase, subunit III
METD_RS24435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
METD_RS24440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
METD_RS24445	COG0477	Major facilitator Superfamily
METD_RS24450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
METD_RS24460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS24470	COG2197	response regulator
METD_RS24490	COG2197	response regulator
METD_RS24495	COG2197	response regulator
METD_RS24590	COG4227	nucleotidyltransferase activity
METD_RS24615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
METD_RS24635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
METD_RS24675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
METD_RS24700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
METD_RS24720	COG1309	transcriptional regulator
METD_RS24725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS24735	COG1309	transcriptional regulator
METD_RS24755	COG2207	Transcriptional regulator
METD_RS24785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS24790	COG1116	anion transmembrane transporter activity
METD_RS24805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
METD_RS24810	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS24825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
METD_RS24855	COG1877	trehalose-phosphatase activity
METD_RS24885	COG3383	formate dehydrogenase (NAD+) activity
METD_RS24895	COG0583	DNA-binding transcription factor activity
METD_RS24905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
METD_RS24920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
METD_RS24925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
METD_RS24930	COG0433	COG0433 Predicted ATPase
METD_RS24980	COG1597	lipid kinase activity
METD_RS24990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
METD_RS25000	COG0784	Response regulator, receiver
METD_RS25000	COG5002	protein histidine kinase activity
METD_RS25000	COG2205	protein histidine kinase activity
METD_RS25010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
METD_RS25015	COG3178	'Phosphotransferase
METD_RS25020	COG2205	protein histidine kinase activity
METD_RS25025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
METD_RS25030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
METD_RS25040	COG1024	Enoyl-CoA hydratase
METD_RS25060	COG1074	ATP-dependent DNA helicase activity
METD_RS25065	COG2133	pyrroloquinoline quinone binding
METD_RS25075	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
METD_RS25080	COG0285	dihydrofolate synthase activity
METD_RS25085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
METD_RS25090	COG0159	tryptophan synthase activity
METD_RS25095	COG2816	NAD+ diphosphatase activity
METD_RS25110	COG0513	Belongs to the DEAD box helicase family
METD_RS25130	COG0352	thiamine-phosphate diphosphorylase activity
METD_RS25130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
METD_RS25130	COG0351	phosphomethylpyrimidine kinase
METD_RS25135	COG0531	amino acid
METD_RS25145	COG3034	peptidoglycan biosynthetic process
METD_RS25150	COG4988	ABC transporter
METD_RS25165	COG0121	glutamine amidotransferase
METD_RS25175	COG4957	zinc ion binding
METD_RS25190	COG0633	Ferredoxin
METD_RS25205	COG1396	sequence-specific DNA binding
METD_RS25210	COG0351	phosphomethylpyrimidine kinase
METD_RS25215	COG0352	thiamine-phosphate diphosphorylase activity
METD_RS25230	COG4957	zinc ion binding
METD_RS25245	COG0725	ABC transporter, periplasmic molybdate-binding protein
METD_RS25255	COG2264	protein methyltransferase activity
METD_RS25260	COG0006	proline dipeptidase activity
METD_RS25260	COG0006	proline dipeptidase activity
METD_RS25265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
METD_RS25270	COG3001	Fructosamine kinase
METD_RS25295	COG0625	glutathione transferase activity
METD_RS25310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
METD_RS25315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
METD_RS25320	COG1116	anion transmembrane transporter activity
METD_RS25325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
METD_RS25330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS25335	COG1116	anion transmembrane transporter activity
METD_RS25335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
METD_RS25350	COG3387	PFAM Glycoside hydrolase 15-related
METD_RS25360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
METD_RS25365	COG0586	Pfam SNARE associated Golgi protein
METD_RS25395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
METD_RS25400	COG1054	Belongs to the UPF0176 family
METD_RS25405	COG0438	transferase activity, transferring glycosyl groups
METD_RS25415	COG3916	Acyl-homoserine-lactone synthase
METD_RS25420	COG2197	response regulator
METD_RS25575	COG0673	inositol 2-dehydrogenase activity
METD_RS25585	COG0583	DNA-binding transcription factor activity
METD_RS25590	COG1063	alcohol dehydrogenase
METD_RS25595	COG3920	Histidine kinase
METD_RS25595	COG2202	Pas domain
METD_RS25605	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS25620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
METD_RS25625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
METD_RS25635	COG0628	permease
METD_RS25660	COG0071	Belongs to the small heat shock protein (HSP20) family
METD_RS25675	COG0483	inositol monophosphate 1-phosphatase activity
METD_RS25680	COG0628	permease
METD_RS25685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
METD_RS25690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
METD_RS25695	COG3871	stress protein (general stress protein 26)
METD_RS25710	COG0746	molybdenum cofactor guanylyltransferase activity
METD_RS25715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
METD_RS25720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
METD_RS25725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
METD_RS25745	COG0784	Response regulator, receiver
METD_RS25745	COG2205	protein histidine kinase activity
METD_RS25790	COG3383	formate dehydrogenase (NAD+) activity
METD_RS25840	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS25855	COG0657	acetylesterase activity
METD_RS25860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
METD_RS25870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
METD_RS25875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
METD_RS25900	COG2873	o-acetylhomoserine
METD_RS25910	COG0318	PFAM AMP-dependent synthetase and ligase
METD_RS25930	COG1032	radical SAM domain protein
METD_RS25935	COG1320	monovalent cation:proton antiporter activity
METD_RS25940	COG2212	antiporter activity
METD_RS25945	COG1863	multisubunit Na H antiporter MnhE subunit
METD_RS25950	COG0651	ATP synthesis coupled electron transport
METD_RS25955	COG1006	Multisubunit Na H antiporter MnhC subunit
METD_RS25960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
METD_RS25960	COG2111	Na H antiporter
METD_RS25970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
METD_RS25980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS25990	COG0438	transferase activity, transferring glycosyl groups
METD_RS26015	COG0667	Aldo Keto reductase
METD_RS26020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS26050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
METD_RS26055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
METD_RS26070	COG0275	rRNA processing
METD_RS26090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
METD_RS26105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
METD_RS26110	COG1024	Enoyl-CoA hydratase
METD_RS26130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
METD_RS26155	COG0754	glutathionylspermidine amidase activity
METD_RS26165	COG3766	membrane
METD_RS26195	COG0149	triose-phosphate isomerase activity
METD_RS26205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
METD_RS26220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
METD_RS26225	COG0134	indole-3-glycerol-phosphate synthase activity
METD_RS26230	COG0315	cyclic pyranopterin monophosphate synthase activity
METD_RS26235	COG0303	'Molybdopterin
METD_RS26240	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
METD_RS26250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
METD_RS26255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
METD_RS26265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
METD_RS26270	COG1671	Belongs to the UPF0178 family
METD_RS26275	COG0372	Belongs to the citrate synthase family
METD_RS26280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
METD_RS26290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
METD_RS26300	COG0477	Major facilitator Superfamily
METD_RS26305	COG3246	L-lysine catabolic process to acetate
METD_RS26310	COG0473	3-isopropylmalate dehydrogenase activity
METD_RS26320	COG0667	Aldo Keto reductase
METD_RS26345	COG0525	valine-tRNA ligase activity
METD_RS26360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
METD_RS26415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
METD_RS26450	COG0573	inorganic phosphate transmembrane transporter activity
METD_RS26455	COG0581	inorganic phosphate transmembrane transporter activity
METD_RS26460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
METD_RS26465	COG0704	Plays a role in the regulation of phosphate uptake
METD_RS26470	COG0745	RESPONSE REGULATOR receiver
METD_RS26485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
METD_RS26495	COG1492	cobalamin metabolic process
METD_RS26500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
METD_RS26510	COG2814	Major facilitator Superfamily
METD_RS26525	COG3237	CsbD-like
METD_RS26530	COG1028	Short-chain dehydrogenase reductase Sdr
METD_RS26535	COG0825	malonyl-CoA metabolic process
METD_RS26545	COG3034	peptidoglycan biosynthetic process
METD_RS26550	COG0335	large ribosomal subunit rRNA binding
METD_RS26565	COG2951	lytic endotransglycosylase activity
METD_RS26570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
METD_RS26580	COG1183	phosphatidylcholine synthase activity
METD_RS26585	COG0688	phosphatidylethanolamine metabolic process
METD_RS26590	COG5265	(ABC) transporter
METD_RS26610	COG0215	cysteine-tRNA ligase activity
METD_RS26620	COG3045	CreA protein
METD_RS26635	COG2814	Major facilitator Superfamily
METD_RS26645	COG2226	methyltransferase
METD_RS26650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
METD_RS26655	COG1566	PFAM secretion protein HlyD family protein
METD_RS26685	COG0625	glutathione transferase activity
METD_RS26690	COG0823	Involved in the tonB-independent uptake of proteins
METD_RS26700	COG0848	biopolymer transport protein
METD_RS26705	COG0811	peptide transport
METD_RS26715	COG0824	Thioesterase
METD_RS26725	COG2255	four-way junction helicase activity
METD_RS26735	COG0783	Belongs to the Dps family
METD_RS26745	COG0235	Class ii aldolase
METD_RS26750	COG4957	zinc ion binding
METD_RS26770	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
METD_RS26780	COG1192	Involved in chromosome partitioning
METD_RS26795	COG0459	protein refolding
METD_RS26800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
METD_RS26805	COG0598	Magnesium transport protein CorA
METD_RS26810	COG2095	MarC family integral membrane protein
METD_RS26820	COG0277	FAD linked oxidase domain protein
METD_RS26825	COG0306	phosphate transporter
METD_RS26865	COG3739	integral membrane protein
METD_RS26875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
METD_RS26880	COG0484	heat shock protein binding
METD_RS26885	COG1686	Belongs to the peptidase S11 family
METD_RS26890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
METD_RS26905	COG0156	8-amino-7-oxononanoate synthase activity
METD_RS26915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
METD_RS26950	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
METD_RS26955	COG1429	ligase activity, forming nitrogen-metal bonds
METD_RS26960	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
METD_RS26965	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
METD_RS26985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
METD_RS26990	COG2211	Major facilitator Superfamily
METD_RS26995	COG0644	oxidoreductase
METD_RS27015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
METD_RS27020	COG0363	glucosamine-6-phosphate deaminase activity
METD_RS27030	COG1132	(ABC) transporter
METD_RS27035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
METD_RS27050	COG3264	Mechanosensitive ion channel
METD_RS27050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
METD_RS27080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
METD_RS27090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS27095	COG0037	tRNA processing
METD_RS27105	COG2885	chlorophyll binding
METD_RS27115	COG0745	RESPONSE REGULATOR receiver
METD_RS27130	COG0181	hydroxymethylbilane synthase activity
METD_RS27140	COG0405	Gamma-glutamyltransferase
METD_RS27150	COG1129	ABC transporter
METD_RS27195	COG3685	Protein conserved in bacteria
METD_RS27205	COG0028	Belongs to the TPP enzyme family
METD_RS27225	COG0367	asparagine synthase
METD_RS27255	COG3437	response regulator, receiver
METD_RS27270	COG4566	intracellular signal transduction
METD_RS27305	COG0268	Binds directly to 16S ribosomal RNA
METD_RS27455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
METD_RS27625	COG0539	negative regulation of cytoplasmic translation
METD_RS28010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
METD_RS28050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
METD_RS28060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
METD_RS28130	COG4191	Histidine kinase
METD_RS28130	COG0784	Response regulator, receiver
METD_RS28305	COG0837	glucose binding
METD_RS28310	COG0837	glucose binding
METD_RS28315	COG3335	DDE superfamily endonuclease
METD_RS28320	COG0840	transmembrane signaling receptor activity
METD_RS28345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS28350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
METD_RS28360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
METD_RS28420	COG3646	Phage regulatory protein
METD_RS28445	COG0837	glucose binding
METD_RS28450	COG0837	glucose binding