locus-tag	class	description
M446_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M446_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M446_RS00025	COG0514	ATP-dependent DNA helicase (RecQ)
M446_RS00030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M446_RS00040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M446_RS00060	COG0339	signal peptide processing
M446_RS00070	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS00085	COG1174	glycine betaine transport
M446_RS00090	COG1174	glycine betaine transport
M446_RS00100	COG1732	Glycine betaine
M446_RS00110	COG0792	nuclease activity
M446_RS00115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M446_RS00125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M446_RS00140	COG1607	acyl-coa hydrolase
M446_RS00150	COG1758	RNA polymerase activity
M446_RS00160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M446_RS00170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS00180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M446_RS00180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M446_RS00185	COG0604	alcohol dehydrogenase
M446_RS00190	COG2259	Doxx family
M446_RS00200	COG0066	3-isopropylmalate dehydratase activity
M446_RS00205	COG2951	lytic endotransglycosylase activity
M446_RS00210	COG3300	MHYT domain
M446_RS00210	COG5001	Diguanylate cyclase
M446_RS00215	COG2807	transmembrane transport
M446_RS00220	COG0326	Molecular chaperone. Has ATPase activity
M446_RS00225	COG2176	DNA-directed DNA polymerase activity
M446_RS00240	COG0534	Mate efflux family protein
M446_RS00250	COG2814	Major facilitator Superfamily
M446_RS00255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M446_RS00275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS00285	COG0745	RESPONSE REGULATOR receiver
M446_RS00305	COG1881	PFAM PEBP family protein
M446_RS00325	COG4957	zinc ion binding
M446_RS00345	COG0531	amino acid
M446_RS00360	COG0390	transport system, permease component
M446_RS00365	COG3842	ATPase activity
M446_RS00400	COG0842	Transport permease protein
M446_RS00405	COG1129	ABC transporter
M446_RS00405	COG0842	Transport permease protein
M446_RS00410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS00425	COG1132	(ABC) transporter
M446_RS00460	COG2274	protein secretion by the type I secretion system
M446_RS00475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M446_RS00535	COG1215	transferase activity, transferring glycosyl groups
M446_RS00565	COG2079	MmgE PrpD family protein
M446_RS00570	COG1126	abc transporter atp-binding protein
M446_RS00575	COG0765	amino acid transport
M446_RS00590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M446_RS00595	COG0583	DNA-binding transcription factor activity
M446_RS00625	COG0148	phosphopyruvate hydratase activity
M446_RS00645	COG2391	methyltransferase activity
M446_RS00660	COG1388	LysM domain
M446_RS00660	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS00700	COG0737	Belongs to the 5'-nucleotidase family
M446_RS00735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M446_RS00740	COG0640	Transcriptional regulator
M446_RS00785	COG1132	(ABC) transporter
M446_RS00815	COG1566	PFAM secretion protein HlyD family protein
M446_RS00830	COG2091	lysine biosynthetic process via aminoadipic acid
M446_RS00840	COG3321	synthase
M446_RS00840	COG0604	alcohol dehydrogenase
M446_RS00845	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS00850	COG3321	synthase
M446_RS00850	COG0604	alcohol dehydrogenase
M446_RS00860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M446_RS00865	COG2986	histidine ammonia-lyase
M446_RS00910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS00935	COG2801	Transposase and inactivated derivatives
M446_RS00940	COG3328	transposase activity
M446_RS00950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M446_RS01000	COG5001	Diguanylate cyclase
M446_RS01000	COG3300	MHYT domain
M446_RS01005	COG0606	chelatase, subunit chli
M446_RS01010	COG0784	Response regulator, receiver
M446_RS01010	COG2205	protein histidine kinase activity
M446_RS01010	COG5002	protein histidine kinase activity
M446_RS01025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M446_RS01035	COG1968	undecaprenyl-diphosphatase activity
M446_RS01065	COG0481	GTPase activity
M446_RS01070	COG0579	oxidoreductase
M446_RS01075	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M446_RS01085	COG0745	RESPONSE REGULATOR receiver
M446_RS01090	COG0642	Histidine kinase
M446_RS01105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M446_RS01115	COG0523	cobalamin synthesis protein
M446_RS01120	COG1960	acyl-CoA dehydrogenase activity
M446_RS01125	COG1960	acyl-CoA dehydrogenase activity
M446_RS01135	COG0183	Belongs to the thiolase family
M446_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS01145	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS01155	COG0028	Belongs to the TPP enzyme family
M446_RS01185	COG2201	protein-glutamate methylesterase activity
M446_RS01200	COG0529	Catalyzes the synthesis of activated sulfate
M446_RS01235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M446_RS01245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M446_RS01250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M446_RS01255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M446_RS01260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M446_RS01275	COG0275	rRNA processing
M446_RS01280	COG0387	Pfam Sodium calcium exchanger
M446_RS01285	COG0346	lactoylglutathione lyase activity
M446_RS01290	COG0308	aminopeptidase N
M446_RS01295	COG2205	protein histidine kinase activity
M446_RS01295	COG2202	Pas domain
M446_RS01300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M446_RS01310	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M446_RS01325	COG2205	protein histidine kinase activity
M446_RS01330	COG0745	RESPONSE REGULATOR receiver
M446_RS01335	COG4957	zinc ion binding
M446_RS01345	COG0745	RESPONSE REGULATOR receiver
M446_RS01350	COG2885	chlorophyll binding
M446_RS01360	COG0037	tRNA processing
M446_RS01365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M446_RS01370	COG0850	regulation of cytokinetic process
M446_RS01380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M446_RS01390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M446_RS01400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M446_RS01405	COG2080	2 iron, 2 sulfur cluster binding
M446_RS01410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M446_RS01415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M446_RS01420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M446_RS01435	COG0745	RESPONSE REGULATOR receiver
M446_RS01445	COG4251	negative regulation of phosphorylation
M446_RS01520	COG1216	Glycosyl transferase, family 2
M446_RS01520	COG0438	transferase activity, transferring glycosyl groups
M446_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS01530	COG0604	alcohol dehydrogenase
M446_RS01530	COG3321	synthase
M446_RS01535	COG0156	8-amino-7-oxononanoate synthase activity
M446_RS01540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M446_RS01580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M446_RS01585	COG0203	ribosomal protein L17
M446_RS01590	COG0202	RNA polymerase activity
M446_RS01595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M446_RS01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M446_RS01605	COG0563	adenylate kinase activity
M446_RS01610	COG0201	protein transport
M446_RS01615	COG0200	Binds to the 23S rRNA
M446_RS01620	COG1841	ribosomal large subunit assembly
M446_RS01625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M446_RS01630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M446_RS01635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M446_RS01640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M446_RS01645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M446_RS01650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M446_RS01655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M446_RS01660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M446_RS01665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M446_RS01670	COG0255	Belongs to the universal ribosomal protein uL29 family
M446_RS01675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M446_RS01680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M446_RS01685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M446_RS01690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M446_RS01695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M446_RS01700	COG0089	rRNA binding
M446_RS01705	COG0088	Forms part of the polypeptide exit tunnel
M446_RS01710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M446_RS01715	COG0051	transcription antitermination factor activity, RNA binding
M446_RS01720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M446_RS01725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M446_RS01730	COG0049	tRNA binding
M446_RS01735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M446_RS01740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M446_RS01745	COG0085	RNA polymerase activity
M446_RS01750	COG0222	ribosome binding
M446_RS01755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M446_RS01770	COG0081	regulation of translation
M446_RS01775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M446_RS01780	COG0250	Participates in transcription elongation, termination and antitermination
M446_RS01805	COG0840	transmembrane signaling receptor activity
M446_RS01810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M446_RS01815	COG1254	Belongs to the acylphosphatase family
M446_RS01835	COG0625	glutathione transferase activity
M446_RS01840	COG1509	lysine 2,3-aminomutase activity
M446_RS01845	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M446_RS01850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M446_RS01860	COG1278	Cold shock
M446_RS01880	COG4770	biotin carboxylase activity
M446_RS01895	COG0123	including yeast histone deacetylase and acetoin utilization protein
M446_RS01910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M446_RS01910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M446_RS01915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M446_RS01920	COG1530	ribonuclease E activity
M446_RS01920	COG1530	ribonuclease E activity
M446_RS01925	COG0840	transmembrane signaling receptor activity
M446_RS01940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS01945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M446_RS01975	COG0667	Aldo Keto reductase
M446_RS01980	COG4953	penicillin-binding protein 1C
M446_RS01985	COG0181	hydroxymethylbilane synthase activity
M446_RS02005	COG0071	Belongs to the small heat shock protein (HSP20) family
M446_RS02015	COG0483	inositol monophosphate 1-phosphatase activity
M446_RS02020	COG0628	permease
M446_RS02025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M446_RS02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M446_RS02055	COG0047	phosphoribosylformylglycinamidine synthase activity
M446_RS02060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M446_RS02160	COG0625	glutathione transferase activity
M446_RS02175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M446_RS02220	COG1086	Polysaccharide biosynthesis protein
M446_RS02230	COG3045	CreA protein
M446_RS02240	COG0215	cysteine-tRNA ligase activity
M446_RS02260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M446_RS02265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS02290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M446_RS02315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M446_RS02320	COG0285	dihydrofolate synthase activity
M446_RS02325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M446_RS02330	COG0159	tryptophan synthase activity
M446_RS02350	COG1335	isochorismatase
M446_RS02380	COG2835	tetraacyldisaccharide 4'-kinase activity
M446_RS02390	COG1074	ATP-dependent DNA helicase activity
M446_RS02400	COG2887	Belongs to the helicase family. UvrD subfamily
M446_RS02405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M446_RS02410	COG3178	'Phosphotransferase
M446_RS02415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M446_RS02420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M446_RS02425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M446_RS02440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M446_RS02445	COG2205	protein histidine kinase activity
M446_RS02455	COG3273	potassium ion transport
M446_RS02455	COG0471	metal ion transport
M446_RS02470	COG0811	peptide transport
M446_RS02485	COG1609	Transcriptional regulator
M446_RS02500	COG3158	transport of potassium into the cell
M446_RS02515	COG0494	nUDIX hydrolase
M446_RS02545	COG0798	PFAM Bile acid sodium symporter
M446_RS02560	COG0431	NADPH-dependent FMN reductase
M446_RS02565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS02585	COG2814	Major facilitator Superfamily
M446_RS02590	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS02595	COG1802	Transcriptional regulator
M446_RS02610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M446_RS02720	COG0154	amidase activity
M446_RS02735	COG3964	amidohydrolase
M446_RS02740	COG2226	methyltransferase
M446_RS02750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS02770	COG2084	Dehydrogenase
M446_RS02845	COG3047	cAMP biosynthetic process
M446_RS02855	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS02860	COG5001	Diguanylate cyclase
M446_RS02880	COG4957	zinc ion binding
M446_RS02905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS02905	COG2205	protein histidine kinase activity
M446_RS02910	COG0683	leucine binding
M446_RS02925	COG0411	ABC transporter
M446_RS02945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M446_RS02970	COG1696	Membrane protein involved in D-alanine export
M446_RS02985	COG4957	zinc ion binding
M446_RS02990	COG3386	PFAM SMP-30 Gluconolaconase
M446_RS02995	COG2271	Major facilitator Superfamily
M446_RS03005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS03010	COG0667	Aldo Keto reductase
M446_RS03025	COG0659	secondary active sulfate transmembrane transporter activity
M446_RS03030	COG0702	epimerase
M446_RS03035	COG1733	regulation of RNA biosynthetic process
M446_RS03075	COG0586	Pfam SNARE associated Golgi protein
M446_RS03080	COG0432	Pfam Uncharacterised protein family UPF0047
M446_RS03085	COG1793	dna ligase
M446_RS03100	COG0528	UMP kinase activity
M446_RS03105	COG0233	cytoplasmic translational termination
M446_RS03110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M446_RS03125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M446_RS03130	COG0750	zinc metalloprotease
M446_RS03135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M446_RS03150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M446_RS03155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M446_RS03160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M446_RS03170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M446_RS03175	COG0372	Belongs to the citrate synthase family
M446_RS03180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M446_RS03205	COG1671	Belongs to the UPF0178 family
M446_RS03230	COG2814	Major facilitator Superfamily
M446_RS03235	COG0745	RESPONSE REGULATOR receiver
M446_RS03240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M446_RS03240	COG0248	Ppx GppA phosphatase
M446_RS03255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M446_RS03280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M446_RS03290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS03295	COG0601	transmembrane transport
M446_RS03300	COG0747	negative chemotaxis
M446_RS03310	COG1802	Transcriptional regulator
M446_RS03325	COG0121	glutamine amidotransferase
M446_RS03335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M446_RS03335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M446_RS03365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M446_RS03375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M446_RS03380	COG5443	negative regulation of bacterial-type flagellum assembly
M446_RS03390	COG5265	(ABC) transporter
M446_RS03405	COG0688	phosphatidylethanolamine metabolic process
M446_RS03410	COG1183	phosphatidylcholine synthase activity
M446_RS03415	COG0517	IMP dehydrogenase activity
M446_RS03415	COG1994	Peptidase M50
M446_RS03425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M446_RS03430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M446_RS03435	COG0741	lytic transglycosylase activity
M446_RS03465	COG0488	(ABC) transporter
M446_RS03470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M446_RS03490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M446_RS03495	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M446_RS03555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS03610	COG3685	Protein conserved in bacteria
M446_RS03620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M446_RS03665	COG3328	transposase activity
M446_RS03700	COG0410	ABC transporter
M446_RS03720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M446_RS03730	COG4974	Belongs to the 'phage' integrase family
M446_RS03735	COG1250	3-hydroxyacyl-CoA dehydrogenase
M446_RS03745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS03750	COG1116	anion transmembrane transporter activity
M446_RS03755	COG4974	Belongs to the 'phage' integrase family
M446_RS03760	COG2814	Major facilitator Superfamily
M446_RS03775	COG0473	3-isopropylmalate dehydrogenase activity
M446_RS03780	COG0028	Belongs to the TPP enzyme family
M446_RS03785	COG1454	alcohol dehydrogenase
M446_RS03795	COG3243	poly(R)-hydroxyalkanoic acid synthase
M446_RS03805	COG0563	adenylate kinase activity
M446_RS03815	COG0596	Alpha beta hydrolase
M446_RS03825	COG2094	Belongs to the DNA glycosylase MPG family
M446_RS03845	COG0628	permease
M446_RS03850	COG2610	gluconate transmembrane transporter activity
M446_RS03855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M446_RS03940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M446_RS03955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M446_RS03960	COG0395	ABC-type sugar transport system, permease component
M446_RS03975	COG3842	ATPase activity
M446_RS03980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M446_RS03990	COG1454	alcohol dehydrogenase
M446_RS03995	COG3920	Histidine kinase
M446_RS04020	COG4221	oxidoreductase activity
M446_RS04025	COG3781	membrane
M446_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS04085	COG4303	Ethanolamine ammonia lyase large subunit
M446_RS04090	COG4302	ethanolamine ammonia-lyase activity
M446_RS04100	COG0632	four-way junction helicase activity
M446_RS04155	COG2204	response regulator
M446_RS04185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M446_RS04195	COG2814	Major facilitator Superfamily
M446_RS04220	COG1234	tRNA 3'-trailer cleavage
M446_RS04235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M446_RS04255	COG0477	Major facilitator Superfamily
M446_RS04270	COG1752	Esterase of the alpha-beta hydrolase superfamily
M446_RS04280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS04285	COG0601	transmembrane transport
M446_RS04295	COG1473	amidohydrolase
M446_RS04330	COG0392	lysyltransferase activity
M446_RS04345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M446_RS04370	COG2885	chlorophyll binding
M446_RS04380	COG0515	serine threonine protein kinase
M446_RS04425	COG1181	Belongs to the D-alanine--D-alanine ligase family
M446_RS04430	COG2814	Major facilitator Superfamily
M446_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS04450	COG0667	Aldo Keto reductase
M446_RS04475	COG0402	S-adenosylhomocysteine deaminase activity
M446_RS04480	COG1079	Belongs to the binding-protein-dependent transport system permease family
M446_RS04485	COG4603	Belongs to the binding-protein-dependent transport system permease family
M446_RS04490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M446_RS04490	COG0546	phosphoglycolate phosphatase activity
M446_RS04540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS04550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M446_RS04575	COG0546	phosphoglycolate phosphatase activity
M446_RS04600	COG2801	Transposase and inactivated derivatives
M446_RS04615	COG0464	growth
M446_RS04620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M446_RS04620	COG0519	Catalyzes the synthesis of GMP from XMP
M446_RS04625	COG2755	lipolytic protein G-D-S-L family
M446_RS04625	COG0657	acetylesterase activity
M446_RS04670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M446_RS04720	COG0123	including yeast histone deacetylase and acetoin utilization protein
M446_RS04735	COG0753	catalase activity
M446_RS04740	COG4957	zinc ion binding
M446_RS04750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M446_RS04760	COG4372	Transposase
M446_RS04765	COG4372	Transposase
M446_RS04785	COG4957	zinc ion binding
M446_RS04790	COG0776	regulation of translation
M446_RS04835	COG3005	denitrification pathway
M446_RS04845	COG0243	molybdopterin cofactor binding
M446_RS04890	COG4957	zinc ion binding
M446_RS04895	COG2814	Major facilitator Superfamily
M446_RS04910	COG0237	dephospho-CoA kinase activity
M446_RS04915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M446_RS04920	COG0424	maF-like protein
M446_RS04930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M446_RS04935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M446_RS04940	COG1981	membrane
M446_RS04950	COG2169	Transcriptional regulator
M446_RS04950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M446_RS04970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M446_RS04975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M446_RS04985	COG3750	Belongs to the UPF0335 family
M446_RS05010	COG4191	Histidine kinase
M446_RS05010	COG0784	Response regulator, receiver
M446_RS05025	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS05035	COG0596	Alpha beta hydrolase
M446_RS05045	COG0628	permease
M446_RS05085	COG3920	Histidine kinase
M446_RS05105	COG3206	protein involved in exopolysaccharide biosynthesis
M446_RS05105	COG0489	protein tyrosine kinase activity
M446_RS05120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M446_RS05155	COG1702	phosphate starvation-inducible protein PhoH
M446_RS05160	COG0210	DNA helicase
M446_RS05185	COG0330	HflC and HflK could
M446_RS05190	COG0330	HflC and HflK could
M446_RS05200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M446_RS05215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M446_RS05215	COG2124	cytochrome p450
M446_RS05220	COG0114	fumarate hydratase activity
M446_RS05235	COG1309	transcriptional regulator
M446_RS05265	COG2255	four-way junction helicase activity
M446_RS05270	COG1408	metallophosphoesterase
M446_RS05275	COG0824	Thioesterase
M446_RS05285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M446_RS05290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M446_RS05290	COG2813	Specifically methylates the guanine in position
M446_RS05300	COG0477	Major facilitator Superfamily
M446_RS05310	COG0189	ligase activity
M446_RS05315	COG2983	Belongs to the UPF0260 family
M446_RS05320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M446_RS05360	COG0671	phosphoesterase, PA-phosphatase related
M446_RS05375	COG3391	amine dehydrogenase activity
M446_RS05390	COG4774	siderophore transport
M446_RS05395	COG3128	pkhd-type hydroxylase
M446_RS05405	COG0848	biopolymer transport protein
M446_RS05465	COG1459	type II secretion system
M446_RS05490	COG4957	zinc ion binding
M446_RS05565	COG4974	Belongs to the 'phage' integrase family
M446_RS05570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M446_RS05590	COG1450	Type ii and iii secretion system protein
M446_RS05680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M446_RS05685	COG3119	arylsulfatase activity
M446_RS05695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M446_RS05715	COG0714	Associated with various cellular activities
M446_RS05760	COG1566	PFAM secretion protein HlyD family protein
M446_RS05785	COG3547	Transposase (IS116 IS110 IS902 family)
M446_RS05845	COG4566	intracellular signal transduction
M446_RS05855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M446_RS05860	COG1454	alcohol dehydrogenase
M446_RS05865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS05875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS05885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M446_RS05890	COG0508	dehydrogenase complex catalyzes the overall conversion of
M446_RS05895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M446_RS05905	COG0281	malic enzyme
M446_RS05905	COG0280	phosphate acetyltransferase
M446_RS05910	COG1301	dicarboxylic acid transport
M446_RS05915	COG1252	NADH dehydrogenase
M446_RS05920	COG0183	Belongs to the thiolase family
M446_RS05940	COG1271	oxidase subunit
M446_RS05945	COG1294	oxidase, subunit
M446_RS05950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M446_RS05990	COG3360	Dodecin
M446_RS06010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M446_RS06035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS06115	COG4191	Histidine kinase
M446_RS06115	COG0784	Response regulator, receiver
M446_RS06125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M446_RS06130	COG0436	Aminotransferase
M446_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS06145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M446_RS06180	COG1024	Enoyl-CoA hydratase
M446_RS06185	COG0477	Major facilitator Superfamily
M446_RS06195	COG0163	prenyltransferase activity
M446_RS06200	COG0583	DNA-binding transcription factor activity
M446_RS06205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M446_RS06225	COG3842	ATPase activity
M446_RS06230	COG0395	ABC-type sugar transport system, permease component
M446_RS06235	COG1175	transmembrane transport
M446_RS06245	COG0129	dihydroxy-acid dehydratase activity
M446_RS06265	COG4638	Rieske (2fe-2S)
M446_RS06290	COG4948	Mandelate Racemase Muconate Lactonizing
M446_RS06295	COG4829	muconolactone delta-isomerase
M446_RS06300	COG2271	Major facilitator Superfamily
M446_RS06305	COG3246	L-lysine catabolic process to acetate
M446_RS06320	COG1053	succinate dehydrogenase
M446_RS06320	COG3976	FMN-binding domain protein
M446_RS06335	COG1024	Enoyl-CoA hydratase
M446_RS06350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M446_RS06365	COG1522	sequence-specific DNA binding
M446_RS06375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M446_RS06375	COG1017	nitric oxide dioxygenase activity
M446_RS06380	COG0625	glutathione transferase activity
M446_RS06385	COG1309	transcriptional regulator
M446_RS06425	COG0583	DNA-binding transcription factor activity
M446_RS06440	COG2814	Major facilitator Superfamily
M446_RS06465	COG2207	Transcriptional regulator
M446_RS06465	COG1917	Cupin 2, conserved barrel domain protein
M446_RS06470	COG0583	DNA-binding transcription factor activity
M446_RS06505	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M446_RS06530	COG3300	MHYT domain
M446_RS06530	COG5001	Diguanylate cyclase
M446_RS06555	COG0714	Associated with various cellular activities
M446_RS06595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M446_RS06605	COG1999	signal sequence binding
M446_RS06625	COG2171	N-acyltransferase activity
M446_RS06655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M446_RS06660	COG0495	leucyl-tRNA aminoacylation
M446_RS06685	COG0357	Ribosomal RNA small subunit methyltransferase G
M446_RS06690	COG0445	tRNA wobble uridine modification
M446_RS06695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M446_RS06715	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M446_RS06740	COG0656	L-ascorbic acid biosynthetic process
M446_RS06765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M446_RS06785	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M446_RS06790	COG0586	Pfam SNARE associated Golgi protein
M446_RS06800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS06820	COG4774	siderophore transport
M446_RS06840	COG0384	phenazine biosynthesis protein PhzF
M446_RS06860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M446_RS06870	COG2801	Transposase and inactivated derivatives
M446_RS06875	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS06885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M446_RS06890	COG2801	Transposase and inactivated derivatives
M446_RS06920	COG3328	transposase activity
M446_RS06955	COG3436	PFAM IS66 Orf2 family protein
M446_RS07000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M446_RS07025	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS07080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M446_RS07125	COG2267	carboxylic ester hydrolase activity
M446_RS07130	COG0583	DNA-binding transcription factor activity
M446_RS07150	COG2205	protein histidine kinase activity
M446_RS07150	COG5002	protein histidine kinase activity
M446_RS07150	COG0784	Response regulator, receiver
M446_RS07155	COG0784	Response regulator, receiver
M446_RS07175	COG2814	Major facilitator Superfamily
M446_RS07205	COG3158	transport of potassium into the cell
M446_RS07335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M446_RS07350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M446_RS07360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M446_RS07360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS07370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M446_RS07375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M446_RS07440	COG2985	domain, Protein
M446_RS07455	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS07475	COG1464	Belongs to the NlpA lipoprotein family
M446_RS07485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M446_RS07500	COG1477	protein flavinylation
M446_RS07535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M446_RS07575	COG4970	Tfp pilus assembly protein FimT
M446_RS07595	COG4174	ABC transporter (Permease)
M446_RS07600	COG4166	transmembrane transport
M446_RS07605	COG4166	transmembrane transport
M446_RS07615	COG3474	cytochrome
M446_RS07620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M446_RS07635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M446_RS07640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M446_RS07685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M446_RS07695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M446_RS07715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M446_RS07720	COG0395	ABC-type sugar transport system, permease component
M446_RS07725	COG3842	ATPase activity
M446_RS07730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS07735	COG0028	Belongs to the TPP enzyme family
M446_RS07750	COG1653	transport
M446_RS07765	COG1960	acyl-CoA dehydrogenase activity
M446_RS07775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M446_RS07785	COG2986	histidine ammonia-lyase
M446_RS07790	COG1228	amidohydrolase
M446_RS07795	COG0402	S-adenosylhomocysteine deaminase activity
M446_RS07810	COG0392	lysyltransferase activity
M446_RS07815	COG5002	protein histidine kinase activity
M446_RS07835	COG2313	pseudouridylate synthase activity
M446_RS07850	COG2816	NAD+ diphosphatase activity
M446_RS07880	COG0297	glycogen (starch) synthase activity
M446_RS07895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M446_RS07910	COG0824	Thioesterase
M446_RS07915	COG0154	amidase activity
M446_RS07925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M446_RS07935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M446_RS07950	COG2176	DNA-directed DNA polymerase activity
M446_RS07955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M446_RS07960	COG0747	negative chemotaxis
M446_RS07965	COG0601	transmembrane transport
M446_RS07970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS07975	COG0444	Belongs to the ABC transporter superfamily
M446_RS07980	COG4608	Belongs to the ABC transporter superfamily
M446_RS07990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M446_RS08005	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS08010	COG1881	PFAM PEBP family protein
M446_RS08015	COG0737	Belongs to the 5'-nucleotidase family
M446_RS08030	COG4221	oxidoreductase activity
M446_RS08035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS08040	COG1126	abc transporter atp-binding protein
M446_RS08045	COG0765	amino acid transport
M446_RS08050	COG0765	amino acid transport
M446_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS08060	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M446_RS08080	COG0842	Transport permease protein
M446_RS08085	COG1131	(ABC) transporter
M446_RS08090	COG2197	response regulator
M446_RS08095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M446_RS08100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M446_RS08125	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS08150	COG1518	maintenance of DNA repeat elements
M446_RS08155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M446_RS08165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS08175	COG1850	ribulose-bisphosphate carboxylase activity
M446_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS08190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS08210	COG0488	(ABC) transporter
M446_RS08220	COG1126	abc transporter atp-binding protein
M446_RS08225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS08230	COG0765	amino acid transport
M446_RS08235	COG0765	amino acid transport
M446_RS08240	COG0456	acetyltransferase
M446_RS08245	COG2264	protein methyltransferase activity
M446_RS08255	COG0725	ABC transporter, periplasmic molybdate-binding protein
M446_RS08265	COG0314	molybdopterin synthase activity
M446_RS08280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M446_RS08285	COG0354	folic acid binding
M446_RS08290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M446_RS08310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M446_RS08320	COG0247	lactate metabolic process
M446_RS08340	COG0277	FAD linked oxidase domain protein
M446_RS08355	COG0517	IMP dehydrogenase activity
M446_RS08365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M446_RS08370	COG0459	protein refolding
M446_RS08380	COG1024	Enoyl-CoA hydratase
M446_RS08395	COG5001	Diguanylate cyclase
M446_RS08395	COG3300	MHYT domain
M446_RS08405	COG2205	protein histidine kinase activity
M446_RS08435	COG3909	cytochrome
M446_RS08445	COG3706	GGDEF domain
M446_RS08465	COG0653	protein targeting
M446_RS08495	COG0559	Belongs to the binding-protein-dependent transport system permease family
M446_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS08535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M446_RS08545	COG2951	lytic endotransglycosylase activity
M446_RS08570	COG0067	glutamate synthase
M446_RS08570	COG0069	glutamate synthase activity
M446_RS08570	COG0070	glutamate synthase
M446_RS08585	COG0330	HflC and HflK could
M446_RS08610	COG3546	catalase activity
M446_RS08630	COG0010	Belongs to the arginase family
M446_RS08640	COG5001	Diguanylate cyclase
M446_RS08640	COG3300	MHYT domain
M446_RS08655	COG0784	Response regulator, receiver
M446_RS08655	COG4191	Histidine kinase
M446_RS08660	COG0625	glutathione transferase activity
M446_RS08690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M446_RS08700	COG1802	Transcriptional regulator
M446_RS08720	COG5001	Diguanylate cyclase
M446_RS08720	COG3300	MHYT domain
M446_RS08725	COG1335	isochorismatase
M446_RS08740	COG1192	Involved in chromosome partitioning
M446_RS08755	COG4178	(ABC) transporter
M446_RS08765	COG1380	Effector of murein hydrolase LrgA
M446_RS08790	COG3237	CsbD-like
M446_RS08805	COG3328	transposase activity
M446_RS08895	COG3328	transposase activity
M446_RS08930	COG4957	zinc ion binding
M446_RS08975	COG1278	Cold shock
M446_RS09010	COG3328	transposase activity
M446_RS09020	COG0598	Magnesium transport protein CorA
M446_RS09035	COG2133	pyrroloquinoline quinone binding
M446_RS09040	COG2801	Transposase and inactivated derivatives
M446_RS09080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS09090	COG3328	transposase activity
M446_RS09100	COG0683	leucine binding
M446_RS09150	COG1053	succinate dehydrogenase
M446_RS09155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M446_RS09160	COG0066	3-isopropylmalate dehydratase activity
M446_RS09225	COG3243	poly(R)-hydroxyalkanoic acid synthase
M446_RS09235	COG0076	glutamate decarboxylase activity
M446_RS09240	COG0583	DNA-binding transcription factor activity
M446_RS09260	COG2814	Major facilitator Superfamily
M446_RS09275	COG1741	Belongs to the pirin family
M446_RS09280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M446_RS09305	COG0395	ABC-type sugar transport system, permease component
M446_RS09320	COG3842	ATPase activity
M446_RS09430	COG0784	Response regulator, receiver
M446_RS09430	COG3437	response regulator, receiver
M446_RS09460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M446_RS09475	COG1250	3-hydroxyacyl-CoA dehydrogenase
M446_RS09480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M446_RS09485	COG2086	electron transfer activity
M446_RS09505	COG0306	phosphate transporter
M446_RS09505	COG0306	phosphate transporter
M446_RS09515	COG0531	amino acid
M446_RS09570	COG1450	Type ii and iii secretion system protein
M446_RS09590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M446_RS09615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M446_RS09625	COG0277	FAD linked oxidase domain protein
M446_RS09635	COG2137	regulation of response to DNA damage stimulus
M446_RS09660	COG0412	Dienelactone hydrolase
M446_RS09665	COG1275	C4-dicarboxylate transporter malic acid transport protein
M446_RS09675	COG4191	Histidine kinase
M446_RS09675	COG0784	Response regulator, receiver
M446_RS09700	COG0745	RESPONSE REGULATOR receiver
M446_RS09705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M446_RS09715	COG2201	protein-glutamate methylesterase activity
M446_RS09740	COG2192	nodulation
M446_RS09760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M446_RS09780	COG0588	phosphoglycerate mutase activity
M446_RS09825	COG1032	radical SAM domain protein
M446_RS09830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS09850	COG0784	Response regulator, receiver
M446_RS09850	COG4191	Histidine kinase
M446_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS09890	COG0028	Belongs to the TPP enzyme family
M446_RS09910	COG3191	aminopeptidase activity
M446_RS09920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M446_RS09930	COG0494	nUDIX hydrolase
M446_RS09940	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS09945	COG0259	pyridoxamine-phosphate oxidase activity
M446_RS09955	COG0484	heat shock protein binding
M446_RS09970	COG1187	pseudouridine synthase activity
M446_RS09975	COG2813	Specifically methylates the guanine in position
M446_RS09985	COG1960	acyl-CoA dehydrogenase activity
M446_RS10010	COG1703	isobutyryl-CoA mutase activity
M446_RS10015	COG0406	alpha-ribazole phosphatase activity
M446_RS10020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M446_RS10025	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M446_RS10035	COG0523	cobalamin synthesis protein
M446_RS10040	COG0830	nickel cation binding
M446_RS10045	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
M446_RS10050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M446_RS10055	COG1522	sequence-specific DNA binding
M446_RS10060	COG0583	DNA-binding transcription factor activity
M446_RS10065	COG4336	lyase activity
M446_RS10100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M446_RS10110	COG1984	allophanate hydrolase subunit 2
M446_RS10115	COG2814	Major facilitator Superfamily
M446_RS10170	COG3845	ABC transporter
M446_RS10175	COG4603	Belongs to the binding-protein-dependent transport system permease family
M446_RS10180	COG1079	Belongs to the binding-protein-dependent transport system permease family
M446_RS10200	COG1846	Transcriptional regulator
M446_RS10205	COG1921	L-seryl-tRNASec selenium transferase activity
M446_RS10240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M446_RS10250	COG0039	L-malate dehydrogenase activity
M446_RS10255	COG0045	succinate-CoA ligase (ADP-forming) activity
M446_RS10260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M446_RS10265	COG0567	Dehydrogenase, E1 component
M446_RS10275	COG0508	dehydrogenase complex catalyzes the overall conversion of
M446_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS10285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M446_RS10290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M446_RS10295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M446_RS10305	COG4974	Belongs to the 'phage' integrase family
M446_RS10330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M446_RS10340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M446_RS10345	COG0431	NADPH-dependent FMN reductase
M446_RS10350	COG0784	Response regulator, receiver
M446_RS10350	COG4191	Histidine kinase
M446_RS10355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M446_RS10360	COG1137	ATPase activity
M446_RS10365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M446_RS10370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M446_RS10380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS10395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M446_RS10400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M446_RS10420	COG2884	Cell division ATP-binding protein ftsE
M446_RS10430	COG0037	tRNA processing
M446_RS10430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M446_RS10440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M446_RS10460	COG5001	Diguanylate cyclase
M446_RS10465	COG4191	Histidine kinase
M446_RS10465	COG0784	Response regulator, receiver
M446_RS10470	COG0784	Response regulator, receiver
M446_RS10475	COG4251	negative regulation of phosphorylation
M446_RS10485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS10490	COG0601	transmembrane transport
M446_RS10495	COG0747	negative chemotaxis
M446_RS10500	COG0804	urea catabolic process
M446_RS10510	COG0832	Belongs to the urease beta subunit family
M446_RS10510	COG0831	urea catabolic process
M446_RS10515	COG0829	nickel cation binding
M446_RS10525	COG0612	Peptidase, M16
M446_RS10530	COG0612	Peptidase, M16
M446_RS10540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M446_RS10545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M446_RS10555	COG0196	riboflavin kinase activity
M446_RS10560	COG0745	RESPONSE REGULATOR receiver
M446_RS10575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M446_RS10580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M446_RS10645	COG1091	dTDP-4-dehydrorhamnose reductase activity
M446_RS10660	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M446_RS10665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M446_RS10675	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M446_RS10685	COG0483	inositol monophosphate 1-phosphatase activity
M446_RS10690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M446_RS10700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M446_RS10705	COG0840	transmembrane signaling receptor activity
M446_RS10710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M446_RS10715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M446_RS10730	COG1686	Belongs to the peptidase S11 family
M446_RS10740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M446_RS10755	COG1278	Cold shock
M446_RS10765	COG1217	gtp-binding protein TYPA
M446_RS10795	COG0559	Belongs to the binding-protein-dependent transport system permease family
M446_RS10840	COG3920	Histidine kinase
M446_RS10845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M446_RS10855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M446_RS10860	COG0583	DNA-binding transcription factor activity
M446_RS10925	COG1940	carbohydrate kinase activity
M446_RS10930	COG1301	dicarboxylic acid transport
M446_RS10945	COG2271	Major facilitator Superfamily
M446_RS10955	COG0252	asparaginase activity
M446_RS10980	COG0559	Belongs to the binding-protein-dependent transport system permease family
M446_RS10985	COG1022	Amp-dependent synthetase and ligase
M446_RS10995	COG1309	transcriptional regulator
M446_RS11030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M446_RS11035	COG1960	acyl-CoA dehydrogenase activity
M446_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS11045	COG0640	Transcriptional regulator
M446_RS11055	COG0740	serine-type endopeptidase activity
M446_RS11085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M446_RS11090	COG0625	glutathione transferase activity
M446_RS11100	COG0583	DNA-binding transcription factor activity
M446_RS11120	COG4988	ABC transporter
M446_RS11145	COG0612	Peptidase, M16
M446_RS11155	COG3346	SURF1 family
M446_RS11170	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M446_RS11180	COG0109	protoheme IX farnesyltransferase activity
M446_RS11185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M446_RS11195	COG0583	DNA-binding transcription factor activity
M446_RS11220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M446_RS11230	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M446_RS11240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M446_RS11240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M446_RS11250	COG2226	methyltransferase
M446_RS11270	COG0604	alcohol dehydrogenase
M446_RS11275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M446_RS11285	COG0655	NAD(P)H dehydrogenase (quinone) activity
M446_RS11290	COG0009	L-threonylcarbamoyladenylate synthase
M446_RS11295	COG1960	acyl-CoA dehydrogenase activity
M446_RS11300	COG1024	Enoyl-CoA hydratase
M446_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS11325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M446_RS11330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M446_RS11335	COG2032	superoxide dismutase activity
M446_RS11365	COG4964	Belongs to the GSP D family
M446_RS11405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M446_RS11410	COG0193	aminoacyl-tRNA hydrolase activity
M446_RS11415	COG0012	GTP binding
M446_RS11420	COG1515	deoxyribonuclease V activity
M446_RS11425	COG2030	dehydratase
M446_RS11435	COG0183	Belongs to the thiolase family
M446_RS11440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M446_RS11445	COG0596	Alpha beta hydrolase
M446_RS11445	COG2945	thiolester hydrolase activity
M446_RS11550	COG3246	L-lysine catabolic process to acetate
M446_RS11565	COG0113	porphobilinogen synthase activity
M446_RS11575	COG1492	cobalamin metabolic process
M446_RS11600	COG2814	Major facilitator Superfamily
M446_RS11705	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M446_RS11710	COG1797	cobyrinic acid a,c-diamide synthase activity
M446_RS11715	COG1396	sequence-specific DNA binding
M446_RS11725	COG2223	nitrite transmembrane transporter activity
M446_RS11730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M446_RS11745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M446_RS11750	COG0456	acetyltransferase
M446_RS11755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M446_RS11760	COG0316	Belongs to the HesB IscA family
M446_RS11780	COG0281	malic enzyme
M446_RS11780	COG0280	phosphate acetyltransferase
M446_RS11800	COG1960	acyl-CoA dehydrogenase activity
M446_RS11820	COG0018	arginyl-trna synthetase
M446_RS11835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M446_RS11840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M446_RS11845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M446_RS11850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M446_RS11855	COG0805	protein transport
M446_RS11870	COG1862	Preprotein translocase
M446_RS11875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M446_RS11885	COG3737	Protein of unknown function (DUF498/DUF598)
M446_RS11895	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M446_RS11915	COG0616	signal peptide processing
M446_RS11920	COG0776	regulation of translation
M446_RS11930	COG2423	ornithine cyclodeaminase activity
M446_RS11940	COG0071	Belongs to the small heat shock protein (HSP20) family
M446_RS11945	COG0135	phosphoribosylanthranilate isomerase activity
M446_RS11950	COG0133	tryptophan synthase activity
M446_RS11985	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
M446_RS11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS12000	COG3328	transposase activity
M446_RS12015	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS12035	COG0589	response to stress
M446_RS12065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M446_RS12105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M446_RS12110	COG4149	molybdate abc transporter
M446_RS12150	COG0671	phosphoesterase, PA-phosphatase related
M446_RS12155	COG1253	flavin adenine dinucleotide binding
M446_RS12160	COG1597	lipid kinase activity
M446_RS12175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M446_RS12180	COG0405	Gamma-glutamyltransferase
M446_RS12215	COG0483	inositol monophosphate 1-phosphatase activity
M446_RS12230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M446_RS12235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M446_RS12240	COG2080	2 iron, 2 sulfur cluster binding
M446_RS12245	COG3920	Histidine kinase
M446_RS12245	COG2202	Pas domain
M446_RS12255	COG3665	Urea carboxylase-associated protein
M446_RS12265	COG2890	protein-(glutamine-N5) methyltransferase activity
M446_RS12285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS12290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M446_RS12300	COG2205	protein histidine kinase activity
M446_RS12300	COG2202	Pas domain
M446_RS12310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M446_RS12310	COG2010	Cytochrome c
M446_RS12320	COG0443	Heat shock 70 kDa protein
M446_RS12325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M446_RS12340	COG0737	Belongs to the 5'-nucleotidase family
M446_RS12345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M446_RS12350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M446_RS12355	COG1260	myo-inositol-1-phosphate synthase
M446_RS12365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M446_RS12375	COG0045	succinate-CoA ligase (ADP-forming) activity
M446_RS12375	COG1042	CoA-binding domain protein
M446_RS12375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M446_RS12380	COG0360	Binds together with S18 to 16S ribosomal RNA
M446_RS12385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M446_RS12395	COG0359	binds to the 23S rRNA
M446_RS12400	COG0305	Participates in initiation and elongation during chromosome replication
M446_RS12405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M446_RS12410	COG3038	cytochrome b561
M446_RS12425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M446_RS12430	COG4221	oxidoreductase activity
M446_RS12440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M446_RS12470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M446_RS12475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M446_RS12480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M446_RS12495	COG0779	Required for maturation of 30S ribosomal subunits
M446_RS12510	COG0411	ABC transporter
M446_RS12535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M446_RS12540	COG0402	S-adenosylhomocysteine deaminase activity
M446_RS12545	COG3395	kinase activity
M446_RS12550	COG3622	Belongs to the hyi family
M446_RS12555	COG2084	Dehydrogenase
M446_RS12560	COG1609	Transcriptional regulator
M446_RS12565	COG0235	Class ii aldolase
M446_RS12570	COG0284	orotidine-5'-phosphate decarboxylase activity
M446_RS12580	COG0538	isocitrate dehydrogenase activity
M446_RS12595	COG2204	response regulator
M446_RS12610	COG5328	Belongs to the UPF0262 family
M446_RS12615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M446_RS12630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M446_RS12635	COG0156	8-amino-7-oxononanoate synthase activity
M446_RS12645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M446_RS12650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M446_RS12655	COG0124	histidyl-tRNA synthetase
M446_RS12670	COG0583	DNA-binding transcription factor activity
M446_RS12675	COG0322	excinuclease ABC activity
M446_RS12680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M446_RS12695	COG0803	Belongs to the bacterial solute-binding protein 9 family
M446_RS12705	COG1335	isochorismatase
M446_RS12715	COG3338	carbonate dehydratase activity
M446_RS12735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M446_RS12745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M446_RS12760	COG2080	2 iron, 2 sulfur cluster binding
M446_RS12765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M446_RS12770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M446_RS12775	COG0588	phosphoglycerate mutase activity
M446_RS12805	COG1363	Peptidase, m42
M446_RS12810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M446_RS12810	COG0189	ligase activity
M446_RS12815	COG0367	asparagine synthase
M446_RS12825	COG0784	Response regulator, receiver
M446_RS12825	COG4191	Histidine kinase
M446_RS12835	COG0235	Class ii aldolase
M446_RS12850	COG1902	pentaerythritol trinitrate reductase activity
M446_RS12860	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS12880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M446_RS12915	COG0708	Exodeoxyribonuclease III
M446_RS12930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS12935	COG4608	Belongs to the ABC transporter superfamily
M446_RS12940	COG0444	Belongs to the ABC transporter superfamily
M446_RS12960	COG3409	Peptidoglycan-binding domain 1 protein
M446_RS12960	COG3773	Cell wall hydrolase
M446_RS12970	COG0574	Belongs to the PEP-utilizing enzyme family
M446_RS12970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M446_RS12975	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS12975	COG1388	LysM domain
M446_RS12980	COG5001	Diguanylate cyclase
M446_RS12980	COG3300	MHYT domain
M446_RS12985	COG0028	Belongs to the TPP enzyme family
M446_RS13000	COG0346	lactoylglutathione lyase activity
M446_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS13015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS13015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M446_RS13020	COG1132	(ABC) transporter
M446_RS13045	COG0784	Response regulator, receiver
M446_RS13075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M446_RS13085	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS13130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS13135	COG2084	Dehydrogenase
M446_RS13140	COG3958	Transketolase
M446_RS13145	COG3959	Transketolase, thiamine diphosphate binding domain
M446_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS13160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M446_RS13165	COG0142	geranyltranstransferase activity
M446_RS13185	COG2172	sigma factor antagonist activity
M446_RS13195	COG2890	protein-(glutamine-N5) methyltransferase activity
M446_RS13210	COG0752	glycyl-tRNA synthetase alpha subunit
M446_RS13215	COG0751	glycine-tRNA ligase activity
M446_RS13295	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS13360	COG3293	Transposase
M446_RS13375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M446_RS13395	COG2204	response regulator
M446_RS13405	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS13410	COG3852	Histidine kinase
M446_RS13430	COG2205	protein histidine kinase activity
M446_RS13430	COG0784	Response regulator, receiver
M446_RS13430	COG5002	protein histidine kinase activity
M446_RS13445	COG1053	succinate dehydrogenase
M446_RS13460	COG3547	Transposase (IS116 IS110 IS902 family)
M446_RS13520	COG0475	glutathione-regulated potassium exporter activity
M446_RS13540	COG4566	intracellular signal transduction
M446_RS13580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M446_RS13595	COG1846	Transcriptional regulator
M446_RS13630	COG0601	transmembrane transport
M446_RS13640	COG0444	Belongs to the ABC transporter superfamily
M446_RS13650	COG4191	Histidine kinase
M446_RS13650	COG0784	Response regulator, receiver
M446_RS13690	COG4263	nitrous-oxide reductase activity
M446_RS13710	COG1959	2 iron, 2 sulfur cluster binding
M446_RS13715	COG4566	intracellular signal transduction
M446_RS13725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M446_RS13730	COG1554	hydrolase, family 65, central catalytic
M446_RS13760	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS13830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M446_RS13835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M446_RS13840	COG1819	glycosyl
M446_RS13865	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS13875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M446_RS13895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M446_RS13905	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M446_RS13910	COG3454	Phosphonate metabolism
M446_RS13915	COG4778	phosphonate C-P lyase system protein PhnL
M446_RS13920	COG4107	phosphonate C-P lyase system protein PhnK
M446_RS13925	COG3627	carbon phosphorus lyase activity
M446_RS13930	COG3626	phosphonate metabolism
M446_RS13935	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M446_RS13940	COG3624	Phosphonate C-P lyase system protein PhnG
M446_RS13945	COG2188	Transcriptional regulator
M446_RS13960	COG3639	organic phosphonate transmembrane transporter activity
M446_RS13965	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M446_RS13970	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M446_RS13980	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M446_RS14010	COG1175	transmembrane transport
M446_RS14020	COG2801	Transposase and inactivated derivatives
M446_RS14075	COG1966	Carbon starvation protein
M446_RS14080	COG2879	small protein
M446_RS14090	COG2183	response to ionizing radiation
M446_RS14115	COG0477	Major facilitator Superfamily
M446_RS14130	COG3162	membrane
M446_RS14145	COG0297	glycogen (starch) synthase activity
M446_RS14160	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS14180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M446_RS14180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M446_RS14190	COG0138	bifunctional purine biosynthesis protein purh
M446_RS14235	COG0747	negative chemotaxis
M446_RS14265	COG1278	Cold shock
M446_RS14310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M446_RS14315	COG2010	Cytochrome c
M446_RS14315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M446_RS14320	COG2010	Cytochrome c
M446_RS14335	COG1309	transcriptional regulator
M446_RS14360	COG2202	Pas domain
M446_RS14360	COG3920	Histidine kinase
M446_RS14410	COG0167	dihydroorotate dehydrogenase activity
M446_RS14415	COG0543	2 iron, 2 sulfur cluster binding
M446_RS14420	COG2814	Major facilitator Superfamily
M446_RS14480	COG1338	Plays a role in the flagellum-specific transport system
M446_RS14490	COG1132	(ABC) transporter
M446_RS14495	COG0463	Glycosyl transferase, family 2
M446_RS14520	COG0277	FAD linked oxidase domain protein
M446_RS14555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M446_RS14570	COG0739	heme binding
M446_RS14600	COG0446	pyridine nucleotide-disulphide oxidoreductase
M446_RS14610	COG3161	chorismate lyase activity
M446_RS14625	COG1132	(ABC) transporter
M446_RS14630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M446_RS14645	COG1196	nuclear chromosome segregation
M446_RS14645	COG3264	Mechanosensitive ion channel
M446_RS14680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M446_RS14695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M446_RS14700	COG0800	Aldolase
M446_RS14705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M446_RS14710	COG1692	metallophosphoesterase
M446_RS14725	COG0058	SHG alpha-glucan phosphorylase activity
M446_RS14730	COG0366	Alpha amylase catalytic
M446_RS14735	COG0297	glycogen (starch) synthase activity
M446_RS14780	COG3383	formate dehydrogenase (NAD+) activity
M446_RS14780	COG0243	molybdopterin cofactor binding
M446_RS14785	COG0437	4 iron, 4 sulfur cluster binding
M446_RS14805	COG0400	carboxylic ester hydrolase activity
M446_RS14810	COG0346	lactoylglutathione lyase activity
M446_RS14815	COG0583	DNA-binding transcription factor activity
M446_RS14840	COG0789	Transcriptional regulator
M446_RS14855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M446_RS14855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M446_RS14860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M446_RS14865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M446_RS14890	COG2309	aminopeptidase activity
M446_RS14955	COG1192	Involved in chromosome partitioning
M446_RS14960	COG2186	Transcriptional regulator
M446_RS14965	COG2084	Dehydrogenase
M446_RS14970	COG0765	amino acid transport
M446_RS14975	COG0765	amino acid transport
M446_RS14980	COG1126	abc transporter atp-binding protein
M446_RS14990	COG0698	ribose 5-phosphate isomerase
M446_RS14995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M446_RS15010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M446_RS15010	COG2010	Cytochrome c
M446_RS15015	COG2080	2 iron, 2 sulfur cluster binding
M446_RS15025	COG0252	asparaginase activity
M446_RS15035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M446_RS15060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M446_RS15065	COG1937	Protein conserved in bacteria
M446_RS15080	COG2989	Protein conserved in bacteria
M446_RS15090	COG1131	(ABC) transporter
M446_RS15140	COG1877	trehalose-phosphatase activity
M446_RS15155	COG1131	(ABC) transporter
M446_RS15210	COG3246	L-lysine catabolic process to acetate
M446_RS15215	COG1396	sequence-specific DNA binding
M446_RS15220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M446_RS15225	COG1253	flavin adenine dinucleotide binding
M446_RS15230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M446_RS15235	COG1702	phosphate starvation-inducible protein PhoH
M446_RS15240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M446_RS15255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M446_RS15260	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS15265	COG1473	amidohydrolase
M446_RS15275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M446_RS15280	COG3845	ABC transporter
M446_RS15290	COG4251	negative regulation of phosphorylation
M446_RS15295	COG0194	GDP metabolic process
M446_RS15300	COG1561	YicC-like family, N-terminal region
M446_RS15305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M446_RS15315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M446_RS15320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M446_RS15330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M446_RS15335	COG1968	undecaprenyl-diphosphatase activity
M446_RS15340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M446_RS15350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M446_RS15355	COG1403	HNH endonuclease
M446_RS15370	COG0505	Belongs to the CarA family
M446_RS15375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS15380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M446_RS15395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M446_RS15400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M446_RS15405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M446_RS15435	COG1360	Flagellar Motor Protein
M446_RS15450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M446_RS15455	COG1335	isochorismatase
M446_RS15465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M446_RS15470	COG1752	Esterase of the alpha-beta hydrolase superfamily
M446_RS15475	COG0516	GMP reductase activity
M446_RS15475	COG0517	IMP dehydrogenase activity
M446_RS15495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M446_RS15500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M446_RS15555	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M446_RS15565	COG0006	proline dipeptidase activity
M446_RS15565	COG0006	proline dipeptidase activity
M446_RS15575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS15590	COG2205	protein histidine kinase activity
M446_RS15590	COG0784	Response regulator, receiver
M446_RS15590	COG2198	Histidine kinase
M446_RS15605	COG0167	dihydroorotate dehydrogenase activity
M446_RS15610	COG0534	Mate efflux family protein
M446_RS15620	COG0657	acetylesterase activity
M446_RS15640	COG2721	sulfolactate sulfo-lyase activity
M446_RS15645	COG3383	formate dehydrogenase (NAD+) activity
M446_RS15665	COG3278	Belongs to the heme-copper respiratory oxidase family
M446_RS15680	COG2010	Cytochrome c
M446_RS15685	COG0303	'Molybdopterin
M446_RS15690	COG1763	Mo-molybdopterin cofactor biosynthetic process
M446_RS15705	COG1960	acyl-CoA dehydrogenase activity
M446_RS15710	COG0183	Belongs to the thiolase family
M446_RS15720	COG1250	3-hydroxyacyl-CoA dehydrogenase
M446_RS15720	COG1024	Enoyl-CoA hydratase
M446_RS15725	COG0251	oxidation-reduction process
M446_RS15740	COG0753	catalase activity
M446_RS15750	COG3180	Ammonia monooxygenase
M446_RS15755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M446_RS15760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M446_RS15770	COG1496	oxidoreductase activity
M446_RS15775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M446_RS15790	COG0346	lactoylglutathione lyase activity
M446_RS15795	COG0837	glucose binding
M446_RS15800	COG1250	3-hydroxyacyl-CoA dehydrogenase
M446_RS15805	COG1802	Transcriptional regulator
M446_RS15810	COG0583	DNA-binding transcription factor activity
M446_RS15835	COG1216	Glycosyl transferase, family 2
M446_RS15845	COG1215	transferase activity, transferring glycosyl groups
M446_RS15850	COG1132	(ABC) transporter
M446_RS15860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M446_RS15885	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
M446_RS15890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS15915	COG0288	reversible hydration of carbon dioxide
M446_RS16040	COG0776	regulation of translation
M446_RS16060	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS16065	COG2133	pyrroloquinoline quinone binding
M446_RS16100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M446_RS16125	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
M446_RS16130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS16145	COG0823	Involved in the tonB-independent uptake of proteins
M446_RS16155	COG0848	biopolymer transport protein
M446_RS16160	COG0811	peptide transport
M446_RS16175	COG1214	PFAM Peptidase M22, glycoprotease
M446_RS16180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M446_RS16190	COG0335	large ribosomal subunit rRNA binding
M446_RS16205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M446_RS16210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M446_RS16220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M446_RS16230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M446_RS16250	COG1960	acyl-CoA dehydrogenase activity
M446_RS16255	COG0564	pseudouridine synthase activity
M446_RS16260	COG0552	protein localization to endoplasmic reticulum
M446_RS16265	COG2917	probably involved in intracellular septation
M446_RS16270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M446_RS16275	COG0180	Tryptophanyl-tRNA synthetase
M446_RS16290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M446_RS16300	COG1061	Type III restriction enzyme res subunit
M446_RS16310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M446_RS16330	COG2271	Major facilitator Superfamily
M446_RS16335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS16340	COG0840	transmembrane signaling receptor activity
M446_RS16355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M446_RS16355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M446_RS16365	COG1621	beta-fructofuranosidase activity
M446_RS16375	COG1609	Transcriptional regulator
M446_RS16385	COG1595	DNA-templated transcription, initiation
M446_RS16395	COG4178	(ABC) transporter
M446_RS16410	COG1404	Belongs to the peptidase S8 family
M446_RS16415	COG0156	8-amino-7-oxononanoate synthase activity
M446_RS16425	COG0303	'Molybdopterin
M446_RS16450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M446_RS16465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS16470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M446_RS16475	COG0626	cystathionine gamma-synthase activity
M446_RS16490	COG1116	anion transmembrane transporter activity
M446_RS16500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M446_RS16500	COG1116	anion transmembrane transporter activity
M446_RS16505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M446_RS16510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M446_RS16550	COG0235	Class ii aldolase
M446_RS16585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M446_RS16590	COG2814	Major facilitator Superfamily
M446_RS16605	COG1024	Enoyl-CoA hydratase
M446_RS16610	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS16620	COG4948	Mandelate Racemase Muconate Lactonizing
M446_RS16630	COG0366	Alpha amylase catalytic
M446_RS16655	COG1802	Transcriptional regulator
M446_RS16660	COG0247	lactate metabolic process
M446_RS16660	COG0277	FAD linked oxidase domain protein
M446_RS16665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M446_RS16710	COG0463	Glycosyl transferase, family 2
M446_RS16710	COG0457	Tetratricopeptide repeat
M446_RS16715	COG0596	Alpha beta hydrolase
M446_RS16720	COG0402	S-adenosylhomocysteine deaminase activity
M446_RS16735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS16745	COG0656	L-ascorbic acid biosynthetic process
M446_RS16780	COG1215	transferase activity, transferring glycosyl groups
M446_RS16785	COG0024	Methionine aminopeptidase
M446_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS16795	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS16815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M446_RS16825	COG0559	Belongs to the binding-protein-dependent transport system permease family
M446_RS16850	COG0129	dihydroxy-acid dehydratase activity
M446_RS16860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M446_RS16865	COG0509	glycine decarboxylation via glycine cleavage system
M446_RS16870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M446_RS16870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M446_RS16875	COG3604	Transcriptional regulator
M446_RS16880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M446_RS16900	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
M446_RS16905	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS16910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS16915	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS16920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS16925	COG1433	Dinitrogenase iron-molybdenum cofactor
M446_RS16935	COG5420	small protein containing a coiled-coil domain
M446_RS16940	COG3383	formate dehydrogenase (NAD+) activity
M446_RS16955	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS16960	COG1301	dicarboxylic acid transport
M446_RS16965	COG0280	phosphate acetyltransferase
M446_RS16965	COG0281	malic enzyme
M446_RS16975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M446_RS16980	COG0477	Major facilitator Superfamily
M446_RS16990	COG0628	permease
M446_RS17015	COG0784	Response regulator, receiver
M446_RS17015	COG2205	protein histidine kinase activity
M446_RS17030	COG1192	Involved in chromosome partitioning
M446_RS17035	COG1475	DNA binding
M446_RS17055	COG4221	oxidoreductase activity
M446_RS17075	COG0517	IMP dehydrogenase activity
M446_RS17085	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M446_RS17090	COG3585	molybdate ion transport
M446_RS17100	COG0644	oxidoreductase
M446_RS17105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M446_RS17110	COG2086	electron transfer activity
M446_RS17130	COG1104	cysteine desulfurase activity
M446_RS17140	COG0316	Belongs to the HesB IscA family
M446_RS17145	COG1719	4-vinyl reductase, 4VR
M446_RS17155	COG1396	sequence-specific DNA binding
M446_RS17160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS17165	COG0765	amino acid transport
M446_RS17170	COG1126	abc transporter atp-binding protein
M446_RS17175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M446_RS17180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M446_RS17205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M446_RS17205	COG0517	IMP dehydrogenase activity
M446_RS17205	COG0617	tRNA 3'-terminal CCA addition
M446_RS17215	COG5554	nitrogen fixation
M446_RS17220	COG5554	nitrogen fixation
M446_RS17230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M446_RS17235	COG0535	radical SAM domain protein
M446_RS17240	COG0402	S-adenosylhomocysteine deaminase activity
M446_RS17250	COG1116	anion transmembrane transporter activity
M446_RS17270	COG2186	Transcriptional regulator
M446_RS17285	COG2195	Cleaves the N-terminal amino acid of tripeptides
M446_RS17290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M446_RS17300	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS17315	COG1477	protein flavinylation
M446_RS17380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS17385	COG0765	amino acid transport
M446_RS17390	COG1126	abc transporter atp-binding protein
M446_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS17415	COG0662	Cupin 2, conserved barrel domain protein
M446_RS17425	COG1129	ABC transporter
M446_RS17460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M446_RS17495	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS17505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M446_RS17520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M446_RS17525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M446_RS17535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M446_RS17545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M446_RS17555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M446_RS17560	COG4133	protoheme IX ABC transporter activity
M446_RS17565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M446_RS17580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M446_RS17600	COG0778	Nitroreductase
M446_RS17610	COG1815	bacterial-type flagellum-dependent cell motility
M446_RS17615	COG1558	bacterial-type flagellum-dependent cell motility
M446_RS17625	COG4786	Flagellar basal body rod
M446_RS17630	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M446_RS17635	COG1706	bacterial-type flagellum-dependent cell motility
M446_RS17645	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M446_RS17650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M446_RS17655	COG0228	four-way junction DNA binding
M446_RS17660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M446_RS17680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M446_RS17690	COG0850	regulation of cytokinetic process
M446_RS17715	COG0142	geranyltranstransferase activity
M446_RS17720	COG0500	methyltransferase
M446_RS17725	COG1063	alcohol dehydrogenase
M446_RS17730	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
M446_RS17735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS17740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS17805	COG0644	oxidoreductase
M446_RS17810	COG2211	Major facilitator Superfamily
M446_RS17815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M446_RS17835	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS17840	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M446_RS17845	COG1429	ligase activity, forming nitrogen-metal bonds
M446_RS17850	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
M446_RS17860	COG2814	Major facilitator Superfamily
M446_RS17885	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M446_RS17895	COG0156	8-amino-7-oxononanoate synthase activity
M446_RS17905	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
M446_RS17915	COG1233	COG1233 Phytoene dehydrogenase and related
M446_RS17920	COG1562	ergosterol biosynthetic process
M446_RS17925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M446_RS17935	COG3387	PFAM Glycoside hydrolase 15-related
M446_RS17945	COG3707	response regulator
M446_RS17955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M446_RS17960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS17965	COG1116	anion transmembrane transporter activity
M446_RS17970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M446_RS17975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M446_RS17980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M446_RS17985	COG0243	molybdopterin cofactor binding
M446_RS17990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M446_RS17990	COG1648	precorrin-2 dehydrogenase activity
M446_RS18000	COG1309	transcriptional regulator
M446_RS18005	COG2814	Major facilitator Superfamily
M446_RS18065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M446_RS18070	COG1999	signal sequence binding
M446_RS18085	COG0625	glutathione transferase activity
M446_RS18095	COG3844	kynureninase activity
M446_RS18120	COG1295	ribonuclease BN
M446_RS18155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M446_RS18165	COG2255	four-way junction helicase activity
M446_RS18190	COG0583	DNA-binding transcription factor activity
M446_RS18195	COG0492	ferredoxin-NADP+ reductase activity
M446_RS18205	COG1522	sequence-specific DNA binding
M446_RS18220	COG0739	heme binding
M446_RS18225	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
M446_RS18235	COG1691	(AIR) carboxylase
M446_RS18250	COG2226	methyltransferase
M446_RS18270	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS18285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M446_RS18290	COG1408	metallophosphoesterase
M446_RS18300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M446_RS18325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS18335	COG0436	Aminotransferase
M446_RS18385	COG3938	Belongs to the proline racemase family
M446_RS18420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M446_RS18430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M446_RS18440	COG2902	Dehydrogenase
M446_RS18445	COG3547	Transposase (IS116 IS110 IS902 family)
M446_RS18455	COG3842	ATPase activity
M446_RS18465	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS18475	COG1176	ABC-type spermidine putrescine transport system, permease component I
M446_RS18485	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS18495	COG1902	pentaerythritol trinitrate reductase activity
M446_RS18495	COG0446	pyridine nucleotide-disulphide oxidoreductase
M446_RS18505	COG3842	ATPase activity
M446_RS18515	COG1176	ABC-type spermidine putrescine transport system, permease component I
M446_RS18525	COG1396	sequence-specific DNA binding
M446_RS18530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M446_RS18655	COG1845	cytochrome c oxidase, subunit III
M446_RS18665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M446_RS18670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M446_RS18685	COG0840	transmembrane signaling receptor activity
M446_RS18690	COG5001	Diguanylate cyclase
M446_RS18695	COG0071	Belongs to the small heat shock protein (HSP20) family
M446_RS18725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M446_RS18735	COG1309	transcriptional regulator
M446_RS18780	COG0747	negative chemotaxis
M446_RS18785	COG4608	Belongs to the ABC transporter superfamily
M446_RS18790	COG0444	Belongs to the ABC transporter superfamily
M446_RS18795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS18800	COG0601	transmembrane transport
M446_RS18805	COG0747	negative chemotaxis
M446_RS18810	COG3964	amidohydrolase
M446_RS18825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M446_RS18835	COG1595	DNA-templated transcription, initiation
M446_RS18845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS18850	COG1960	acyl-CoA dehydrogenase activity
M446_RS18870	COG1872	DUF167
M446_RS18875	COG2030	dehydratase
M446_RS18880	COG1321	iron dependent repressor
M446_RS18890	COG3842	ATPase activity
M446_RS18905	COG0745	RESPONSE REGULATOR receiver
M446_RS18930	COG0392	lysyltransferase activity
M446_RS18945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS18950	COG0372	Belongs to the citrate synthase family
M446_RS18955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M446_RS19175	COG4372	Transposase
M446_RS19200	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS19225	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS19270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS19280	COG0438	transferase activity, transferring glycosyl groups
M446_RS19285	COG0438	transferase activity, transferring glycosyl groups
M446_RS19305	COG3534	alpha-L-arabinofuranosidase
M446_RS19320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS19335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M446_RS19340	COG0438	transferase activity, transferring glycosyl groups
M446_RS19365	COG2351	hydroxyisourate hydrolase activity
M446_RS19370	COG0154	amidase activity
M446_RS19375	COG3842	ATPase activity
M446_RS19380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M446_RS19385	COG1176	ABC-type spermidine putrescine transport system, permease component I
M446_RS19400	COG2951	lytic endotransglycosylase activity
M446_RS19410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M446_RS19420	COG4191	Histidine kinase
M446_RS19630	COG4957	zinc ion binding
M446_RS19700	COG4957	zinc ion binding
M446_RS19835	COG0616	signal peptide processing
M446_RS19950	COG3328	transposase activity
M446_RS19975	COG0612	Peptidase, M16
M446_RS19980	COG0612	Peptidase, M16
M446_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS19995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M446_RS20000	COG0745	RESPONSE REGULATOR receiver
M446_RS20010	COG1749	Flagellar hook protein flgE
M446_RS20040	COG1706	bacterial-type flagellum-dependent cell motility
M446_RS20050	COG1696	Membrane protein involved in D-alanine export
M446_RS20065	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M446_RS20075	COG4786	Flagellar basal body rod
M446_RS20080	COG4786	Flagellar basal body rod
M446_RS20110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M446_RS20110	COG0551	DNA topoisomerase type I activity
M446_RS20125	COG3300	MHYT domain
M446_RS20125	COG5001	Diguanylate cyclase
M446_RS20140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M446_RS20145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M446_RS20155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M446_RS20160	COG0784	Response regulator, receiver
M446_RS20160	COG4191	Histidine kinase
M446_RS20165	COG3920	Histidine kinase
M446_RS20165	COG2202	Pas domain
M446_RS20170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M446_RS20180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M446_RS20190	COG0799	negative regulation of ribosome biogenesis
M446_RS20195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M446_RS20205	COG0793	Belongs to the peptidase S41A family
M446_RS20215	COG0494	nUDIX hydrolase
M446_RS20230	COG0071	Belongs to the small heat shock protein (HSP20) family
M446_RS20250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M446_RS20255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M446_RS20265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M446_RS20280	COG0101	tRNA pseudouridine synthase activity
M446_RS20285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M446_RS20290	COG0242	peptide deformylase activity
M446_RS20295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M446_RS20300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M446_RS20305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M446_RS20325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M446_RS20335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M446_RS20345	COG1201	RNA secondary structure unwinding
M446_RS20355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M446_RS20360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M446_RS20365	COG1764	response to oxidative stress
M446_RS20370	COG1846	Transcriptional regulator
M446_RS20375	COG1902	pentaerythritol trinitrate reductase activity
M446_RS20435	COG0649	NAD binding
M446_RS20440	COG2094	Belongs to the DNA glycosylase MPG family
M446_RS20450	COG0366	Alpha amylase catalytic
M446_RS20465	COG0586	Pfam SNARE associated Golgi protein
M446_RS20470	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS20575	COG2433	Pfam Transposase IS66
M446_RS20585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M446_RS20590	COG2124	cytochrome p450
M446_RS20605	COG2226	methyltransferase
M446_RS20620	COG0424	maF-like protein
M446_RS20625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M446_RS20640	COG1381	Involved in DNA repair and RecF pathway recombination
M446_RS20645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M446_RS20650	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS20655	COG2873	o-acetylhomoserine
M446_RS20675	COG1271	oxidase subunit
M446_RS20680	COG1294	oxidase, subunit
M446_RS20705	COG0254	rRNA binding
M446_RS20710	COG1132	(ABC) transporter
M446_RS20715	COG0316	Belongs to the HesB IscA family
M446_RS20725	COG0513	Belongs to the DEAD box helicase family
M446_RS20735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M446_RS20740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M446_RS20750	COG0154	amidase activity
M446_RS20755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M446_RS20775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M446_RS20785	COG0758	DNA mediated transformation
M446_RS20790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M446_RS20795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M446_RS20800	COG0540	Belongs to the ATCase OTCase family
M446_RS20805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M446_RS20815	COG0187	DNA topoisomerase II activity
M446_RS20820	COG1063	alcohol dehydrogenase
M446_RS20850	COG0625	glutathione transferase activity
M446_RS20860	COG0105	UTP biosynthetic process
M446_RS20865	COG0243	molybdopterin cofactor binding
M446_RS20875	COG2226	methyltransferase
M446_RS20910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M446_RS20910	COG0493	'glutamate synthase
M446_RS20920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M446_RS20925	COG3023	N-Acetylmuramoyl-L-alanine amidase
M446_RS20945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M446_RS20960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M446_RS20965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M446_RS20980	COG0028	Belongs to the TPP enzyme family
M446_RS21010	COG0840	transmembrane signaling receptor activity
M446_RS21020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M446_RS21025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M446_RS21030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M446_RS21035	COG0649	NAD binding
M446_RS21045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M446_RS21055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M446_RS21060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M446_RS21070	COG0713	ATP synthesis coupled electron transport
M446_RS21085	COG1007	ATP synthesis coupled electron transport
M446_RS21100	COG0346	lactoylglutathione lyase activity
M446_RS21110	COG0442	prolyl-tRNA aminoacylation
M446_RS21120	COG1136	(ABC) transporter
M446_RS21125	COG4239	(ABC) transporter, permease
M446_RS21135	COG0436	Aminotransferase
M446_RS21140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS21145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M446_RS21175	COG4957	zinc ion binding
M446_RS21180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M446_RS21195	COG1253	flavin adenine dinucleotide binding
M446_RS21215	COG3088	subunit of a heme lyase
M446_RS21220	COG1138	Cytochrome C-type biogenesis protein
M446_RS21225	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M446_RS21230	COG4235	cytochrome complex assembly
M446_RS21235	COG2814	Major facilitator Superfamily
M446_RS21275	COG3920	Histidine kinase
M446_RS21280	COG2166	iron-sulfur cluster assembly
M446_RS21290	COG0640	Transcriptional regulator
M446_RS21300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M446_RS21305	COG0629	single-stranded DNA binding
M446_RS21310	COG0596	Alpha beta hydrolase
M446_RS21315	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS21320	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS21340	COG2130	NADP-dependent
M446_RS21355	COG3698	Phosphodiester glycosidase
M446_RS21360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M446_RS21385	COG3118	belongs to the thioredoxin family
M446_RS21390	COG1132	(ABC) transporter
M446_RS21410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M446_RS21420	COG0277	FAD linked oxidase domain protein
M446_RS21435	COG0617	tRNA 3'-terminal CCA addition
M446_RS21460	COG0714	Associated with various cellular activities
M446_RS21505	COG1464	Belongs to the NlpA lipoprotein family
M446_RS21510	COG2011	ABC-type metal ion transport system permease component
M446_RS21515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M446_RS21525	COG5001	Diguanylate cyclase
M446_RS21525	COG5002	protein histidine kinase activity
M446_RS21525	COG3447	MASE1 domain protein
M446_RS21575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS21585	COG3246	L-lysine catabolic process to acetate
M446_RS21590	COG1250	3-hydroxyacyl-CoA dehydrogenase
M446_RS21595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M446_RS21610	COG0556	nucleotide-excision repair
M446_RS21615	COG0583	DNA-binding transcription factor activity
M446_RS21625	COG2514	catechol 2,3-dioxygenase activity
M446_RS21650	COG0741	lytic transglycosylase activity
M446_RS21655	COG4172	Belongs to the ABC transporter superfamily
M446_RS21660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M446_RS21670	COG1309	transcriptional regulator
M446_RS21675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M446_RS21685	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M446_RS21695	COG0336	Belongs to the RNA methyltransferase TrmD family
M446_RS21710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M446_RS21720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M446_RS21750	COG1252	NADH dehydrogenase
M446_RS21760	COG4948	Mandelate Racemase Muconate Lactonizing
M446_RS21770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS21775	COG0765	amino acid transport
M446_RS21780	COG0765	amino acid transport
M446_RS21785	COG1126	abc transporter atp-binding protein
M446_RS21800	COG2855	membrane
M446_RS21805	COG0670	Belongs to the BI1 family
M446_RS21815	COG1595	DNA-templated transcription, initiation
M446_RS21820	COG0405	Gamma-glutamyltransferase
M446_RS21825	COG1280	lysine exporter protein (LysE YggA)
M446_RS21835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M446_RS21865	COG0523	cobalamin synthesis protein
M446_RS21905	COG2066	Belongs to the glutaminase family
M446_RS21915	COG0174	glutamine synthetase
M446_RS21940	COG3300	MHYT domain
M446_RS21940	COG5001	Diguanylate cyclase
M446_RS21965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M446_RS22000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M446_RS22060	COG0435	Glutathione S-transferase
M446_RS22075	COG0671	phosphoesterase, PA-phosphatase related
M446_RS22080	COG1024	Enoyl-CoA hydratase
M446_RS22105	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M446_RS22110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M446_RS22120	COG1024	Enoyl-CoA hydratase
M446_RS22125	COG1832	CoA-binding protein
M446_RS22130	COG2239	Acts as a magnesium transporter
M446_RS22140	COG0154	amidase activity
M446_RS22145	COG0747	negative chemotaxis
M446_RS22150	COG3734	2-keto-3-deoxy-galactonokinase
M446_RS22155	COG0800	Aldolase
M446_RS22160	COG0688	phosphatidylethanolamine metabolic process
M446_RS22165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M446_RS22215	COG3386	PFAM SMP-30 Gluconolaconase
M446_RS22255	COG3246	L-lysine catabolic process to acetate
M446_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS22330	COG0033	Phosphoglucomutase
M446_RS22340	COG3485	protocatechuate 3,4-dioxygenase
M446_RS22345	COG3485	protocatechuate 3,4-dioxygenase
M446_RS22350	COG3246	L-lysine catabolic process to acetate
M446_RS22360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M446_RS22390	COG0783	Belongs to the Dps family
M446_RS22395	COG2989	Protein conserved in bacteria
M446_RS22405	COG1473	amidohydrolase
M446_RS22410	COG0537	adenosine 5'-monophosphoramidase activity
M446_RS22420	COG0513	Belongs to the DEAD box helicase family
M446_RS22475	COG1335	isochorismatase
M446_RS22490	COG3842	ATPase activity
M446_RS22500	COG1176	ABC-type spermidine putrescine transport system, permease component I
M446_RS22505	COG1228	amidohydrolase
M446_RS22550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS22560	COG0179	Fumarylacetoacetate (FAA) hydrolase
M446_RS22640	COG4191	Histidine kinase
M446_RS22640	COG0784	Response regulator, receiver
M446_RS22660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M446_RS22675	COG2963	transposase activity
M446_RS22750	COG2031	fatty acid transporter
M446_RS22765	COG3842	ATPase activity
M446_RS22780	COG1178	ABC-type Fe3 transport system permease component
M446_RS22795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M446_RS22805	COG0527	aspartate kinase activity
M446_RS22810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M446_RS22815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M446_RS22820	COG2890	protein-(glutamine-N5) methyltransferase activity
M446_RS22835	COG0583	DNA-binding transcription factor activity
M446_RS22840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M446_RS22845	COG0477	Major facilitator Superfamily
M446_RS22850	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M446_RS22850	COG1082	Xylose isomerase domain protein TIM barrel
M446_RS22855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M446_RS22860	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS22870	COG0683	leucine binding
M446_RS22875	COG0583	DNA-binding transcription factor activity
M446_RS22885	COG0683	leucine binding
M446_RS22900	COG1129	ABC transporter
M446_RS22905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M446_RS22925	COG2204	response regulator
M446_RS22930	COG4191	Histidine kinase
M446_RS22935	COG1301	dicarboxylic acid transport
M446_RS22940	COG1960	acyl-CoA dehydrogenase activity
M446_RS22960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M446_RS22985	COG2943	transferase activity, transferring hexosyl groups
M446_RS23035	COG2080	2 iron, 2 sulfur cluster binding
M446_RS23035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M446_RS23040	COG3034	peptidoglycan biosynthetic process
M446_RS23050	COG0825	malonyl-CoA metabolic process
M446_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS23065	COG0154	amidase activity
M446_RS23085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M446_RS23105	COG2091	lysine biosynthetic process via aminoadipic acid
M446_RS23110	COG0583	DNA-binding transcription factor activity
M446_RS23115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M446_RS23125	COG0494	nUDIX hydrolase
M446_RS23135	COG2226	methyltransferase
M446_RS23140	COG1040	competence protein
M446_RS23145	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
M446_RS23150	COG1116	anion transmembrane transporter activity
M446_RS23150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M446_RS23155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS23160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M446_RS23165	COG3604	Transcriptional regulator
M446_RS23180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M446_RS23195	COG2223	nitrite transmembrane transporter activity
M446_RS23205	COG0052	Belongs to the universal ribosomal protein uS2 family
M446_RS23210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M446_RS23220	COG0477	Major facilitator Superfamily
M446_RS23245	COG2201	protein-glutamate methylesterase activity
M446_RS23260	COG0643	Histidine kinase
M446_RS23260	COG2198	Histidine kinase
M446_RS23260	COG0784	Response regulator, receiver
M446_RS23275	COG1218	3'(2'),5'-bisphosphate nucleotidase
M446_RS23325	COG3920	Histidine kinase
M446_RS23335	COG0628	permease
M446_RS23340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M446_RS23345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M446_RS23355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M446_RS23360	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS23370	COG3321	synthase
M446_RS23370	COG0604	alcohol dehydrogenase
M446_RS23385	COG1846	Transcriptional regulator
M446_RS23390	COG1289	transmembrane transporter activity
M446_RS23400	COG1566	PFAM secretion protein HlyD family protein
M446_RS23415	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M446_RS23440	COG4191	Histidine kinase
M446_RS23440	COG0784	Response regulator, receiver
M446_RS23450	COG4977	sequence-specific DNA binding
M446_RS23455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M446_RS23460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M446_RS23465	COG0400	carboxylic ester hydrolase activity
M446_RS23475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M446_RS23485	COG0438	transferase activity, transferring glycosyl groups
M446_RS23485	COG1216	Glycosyl transferase, family 2
M446_RS23520	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M446_RS23535	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M446_RS23550	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
M446_RS23555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M446_RS23595	COG0129	dihydroxy-acid dehydratase activity
M446_RS23610	COG1674	ftsk spoiiie
M446_RS23620	COG0708	Exodeoxyribonuclease III
M446_RS23625	COG1414	Transcriptional regulator
M446_RS23635	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS23645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M446_RS23650	COG1185	polyribonucleotide nucleotidyltransferase activity
M446_RS23670	COG2261	transglycosylase associated protein
M446_RS23675	COG0251	oxidation-reduction process
M446_RS23690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M446_RS23735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M446_RS23740	COG1127	ABC transporter
M446_RS23750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M446_RS23750	COG3218	ABC-type transport auxiliary lipoprotein component
M446_RS23760	COG1396	sequence-specific DNA binding
M446_RS23765	COG0351	phosphomethylpyrimidine kinase
M446_RS23770	COG0352	thiamine-phosphate diphosphorylase activity
M446_RS23775	COG0697	spore germination
M446_RS23785	COG0438	transferase activity, transferring glycosyl groups
M446_RS23790	COG4957	zinc ion binding
M446_RS23805	COG4651	solute:proton antiporter activity
M446_RS23805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M446_RS23905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M446_RS23910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M446_RS23915	COG0438	transferase activity, transferring glycosyl groups
M446_RS23940	COG0656	L-ascorbic acid biosynthetic process
M446_RS23980	COG0438	transferase activity, transferring glycosyl groups
M446_RS23985	COG4310	Domain of unknown function (DUF2172)
M446_RS23995	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M446_RS24005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS24015	COG1846	Transcriptional regulator
M446_RS24040	COG0697	spore germination
M446_RS24055	COG0494	nUDIX hydrolase
M446_RS24065	COG0277	FAD linked oxidase domain protein
M446_RS24095	COG1131	(ABC) transporter
M446_RS24170	COG0386	Belongs to the glutathione peroxidase family
M446_RS24205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M446_RS24220	COG1959	2 iron, 2 sulfur cluster binding
M446_RS24225	COG0756	dUTP diphosphatase activity
M446_RS24260	COG3706	GGDEF domain
M446_RS24280	COG2264	protein methyltransferase activity
M446_RS24290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M446_RS24295	COG3158	transport of potassium into the cell
M446_RS24325	COG0129	dihydroxy-acid dehydratase activity
M446_RS24355	COG4264	IucA IucC family
M446_RS24385	COG3648	Uricase
M446_RS24385	COG3195	allantoin biosynthetic process
M446_RS24390	COG0438	transferase activity, transferring glycosyl groups
M446_RS24400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS24440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M446_RS24450	COG0706	membrane insertase activity
M446_RS24455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M446_RS24470	COG0542	response to heat
M446_RS24485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M446_RS24490	COG2233	PERMEase
M446_RS24505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M446_RS24510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M446_RS24515	COG2972	Histidine kinase
M446_RS24515	COG0840	transmembrane signaling receptor activity
M446_RS24530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M446_RS24545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M446_RS24550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M446_RS24555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M446_RS24565	COG0784	Response regulator, receiver
M446_RS24565	COG4191	Histidine kinase
M446_RS24575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M446_RS24580	COG0719	Fe-S assembly protein
M446_RS24585	COG0396	ATPase activity
M446_RS24590	COG0719	Fe-S assembly protein
M446_RS24595	COG1104	cysteine desulfurase activity
M446_RS24600	COG2945	thiolester hydrolase activity
M446_RS24620	COG4191	Histidine kinase
M446_RS24625	COG0398	Pfam SNARE associated Golgi protein
M446_RS24635	COG0482	sulfurtransferase activity
M446_RS24655	COG2204	response regulator
M446_RS24660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M446_RS24670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M446_RS24675	COG1766	The M ring may be actively involved in energy transduction
M446_RS24695	COG1116	anion transmembrane transporter activity
M446_RS24700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M446_RS24705	COG0431	NADPH-dependent FMN reductase
M446_RS24745	COG4608	Belongs to the ABC transporter superfamily
M446_RS24750	COG0444	Belongs to the ABC transporter superfamily
M446_RS24755	COG0601	transmembrane transport
M446_RS24765	COG5001	Diguanylate cyclase
M446_RS24765	COG3300	MHYT domain
M446_RS24800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M446_RS24805	COG1684	flagellar biosynthetic protein fliR
M446_RS24810	COG1987	bacterial-type flagellum assembly
M446_RS24815	COG1677	Flagellar hook-basal body complex protein FliE
M446_RS24820	COG1558	bacterial-type flagellum-dependent cell motility
M446_RS24825	COG1815	bacterial-type flagellum-dependent cell motility
M446_RS24835	COG1338	Plays a role in the flagellum-specific transport system
M446_RS24850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M446_RS24855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M446_RS24860	COG0628	permease
M446_RS24870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M446_RS24875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M446_RS24880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M446_RS24890	COG0156	8-amino-7-oxononanoate synthase activity
M446_RS24895	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M446_RS24905	COG0784	Response regulator, receiver
M446_RS24905	COG2198	Histidine kinase
M446_RS24905	COG2205	protein histidine kinase activity
M446_RS24915	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M446_RS24920	COG2205	protein histidine kinase activity
M446_RS24920	COG0784	Response regulator, receiver
M446_RS24940	COG0477	Major facilitator Superfamily
M446_RS24975	COG4957	zinc ion binding
M446_RS24990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M446_RS25015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M446_RS25025	COG2030	dehydratase
M446_RS25055	COG3750	Belongs to the UPF0335 family
M446_RS25090	COG0469	pyruvate kinase activity
M446_RS25095	COG2267	carboxylic ester hydrolase activity
M446_RS25105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M446_RS25110	COG0840	transmembrane signaling receptor activity
M446_RS25200	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
M446_RS25225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M446_RS25290	COG0473	3-isopropylmalate dehydrogenase activity
M446_RS25295	COG0328	RNA-DNA hybrid ribonuclease activity
M446_RS25300	COG2233	PERMEase
M446_RS25315	COG0346	lactoylglutathione lyase activity
M446_RS25330	COG3479	Phenolic acid decarboxylase
M446_RS25335	COG0583	DNA-binding transcription factor activity
M446_RS25345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M446_RS25350	COG0287	Prephenate dehydrogenase
M446_RS25365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M446_RS25370	COG0508	dehydrogenase complex catalyzes the overall conversion of
M446_RS25375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M446_RS25390	COG0121	glutamine amidotransferase
M446_RS25400	COG1418	mRNA catabolic process
M446_RS25420	COG4106	trans-aconitate 2-methyltransferase activity
M446_RS25440	COG1555	photosystem II stabilization
M446_RS25440	COG1596	polysaccharide export
M446_RS25445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M446_RS25460	COG0183	Belongs to the thiolase family
M446_RS25465	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS25485	COG4783	chaperone-mediated protein folding
M446_RS25500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M446_RS25505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M446_RS25510	COG3920	Histidine kinase
M446_RS25555	COG0778	Nitroreductase
M446_RS25560	COG1959	2 iron, 2 sulfur cluster binding
M446_RS25570	COG0728	peptidoglycan biosynthetic process
M446_RS25575	COG0463	Glycosyl transferase, family 2
M446_RS25580	COG3394	polysaccharide catabolic process
M446_RS25585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M446_RS25600	COG3034	peptidoglycan biosynthetic process
M446_RS25615	COG0321	lipoyl(octanoyl) transferase activity
M446_RS25645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M446_RS25645	COG0072	phenylalanine-tRNA ligase activity
M446_RS25650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M446_RS25655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M446_RS25660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M446_RS25680	COG0840	transmembrane signaling receptor activity
M446_RS25680	COG0840	transmembrane signaling receptor activity
M446_RS25705	COG2326	polyphosphate kinase activity
M446_RS25725	COG0667	Aldo Keto reductase
M446_RS25730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M446_RS25740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M446_RS25745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M446_RS25775	COG0601	transmembrane transport
M446_RS25780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS25785	COG4172	Belongs to the ABC transporter superfamily
M446_RS25825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M446_RS25830	COG1324	tolerance protein
M446_RS25835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M446_RS25875	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS25885	COG1272	protein, Hemolysin III
M446_RS25890	COG1612	heme a metabolic process
M446_RS25920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M446_RS25935	COG1475	DNA binding
M446_RS25940	COG1192	Involved in chromosome partitioning
M446_RS25945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M446_RS25990	COG3237	CsbD-like
M446_RS26010	COG0735	belongs to the Fur family
M446_RS26015	COG1121	(ABC) transporter
M446_RS26040	COG0303	'Molybdopterin
M446_RS26045	COG0315	cyclic pyranopterin monophosphate synthase activity
M446_RS26050	COG0134	indole-3-glycerol-phosphate synthase activity
M446_RS26055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M446_RS26070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M446_RS26080	COG0149	triose-phosphate isomerase activity
M446_RS26090	COG0504	CTP synthase activity
M446_RS26105	COG0754	glutathionylspermidine amidase activity
M446_RS26135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M446_RS26140	COG0583	DNA-binding transcription factor activity
M446_RS26170	COG0521	Mo-molybdopterin cofactor biosynthetic process
M446_RS26175	COG2321	neutral zinc metallopeptidase
M446_RS26180	COG1573	uracil-dna glycosylase
M446_RS26195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS26200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M446_RS26205	COG0439	Biotin carboxylase
M446_RS26210	COG0511	ligase activity, forming carbon-carbon bonds
M446_RS26220	COG0436	Aminotransferase
M446_RS26230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M446_RS26235	COG0683	leucine binding
M446_RS26250	COG1280	lysine exporter protein (LysE YggA)
M446_RS26280	COG0562	UDP-galactopyranose mutase
M446_RS26320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M446_RS26320	COG3608	succinylglutamate desuccinylase aspartoacylase
M446_RS26330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M446_RS26330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M446_RS26335	COG3932	Exopolysaccharide synthesis, ExoD
M446_RS26340	COG5425	PFAM Usg family protein
M446_RS26350	COG3046	protein related to deoxyribodipyrimidine photolyase
M446_RS26355	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS26365	COG3300	MHYT domain
M446_RS26365	COG5001	Diguanylate cyclase
M446_RS26370	COG2814	Major facilitator Superfamily
M446_RS26380	COG3916	Acyl-homoserine-lactone synthase
M446_RS26385	COG2197	response regulator
M446_RS26390	COG0459	protein refolding
M446_RS26395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M446_RS26410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M446_RS26415	COG0670	Belongs to the BI1 family
M446_RS26420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M446_RS26425	COG1136	(ABC) transporter
M446_RS26450	COG0386	Belongs to the glutathione peroxidase family
M446_RS26455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M446_RS26460	COG4208	sulfate ABC transporter
M446_RS26470	COG2895	sulfate adenylyltransferase (ATP) activity
M446_RS26475	COG0175	sulfate reduction
M446_RS26480	COG0175	sulfate reduction
M446_RS26485	COG1522	sequence-specific DNA binding
M446_RS26490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M446_RS26495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M446_RS26500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M446_RS26510	COG0657	acetylesterase activity
M446_RS26515	COG4957	zinc ion binding
M446_RS26530	COG1278	Cold shock
M446_RS26555	COG0693	protein deglycase activity
M446_RS26565	COG0004	ammonium transporteR
M446_RS26570	COG0347	Belongs to the P(II) protein family
M446_RS26575	COG1946	Acyl-CoA thioesterase
M446_RS26580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M446_RS26585	COG2943	transferase activity, transferring hexosyl groups
M446_RS26590	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M446_RS26595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M446_RS26615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M446_RS26630	COG0129	dihydroxy-acid dehydratase activity
M446_RS26640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M446_RS26650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M446_RS26655	COG0343	queuine tRNA-ribosyltransferase activity
M446_RS26675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M446_RS26685	COG0765	amino acid transport
M446_RS26690	COG0765	amino acid transport
M446_RS26695	COG1126	abc transporter atp-binding protein
M446_RS26705	COG0446	pyridine nucleotide-disulphide oxidoreductase
M446_RS26705	COG1902	pentaerythritol trinitrate reductase activity
M446_RS26715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M446_RS26760	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS26775	COG2094	Belongs to the DNA glycosylase MPG family
M446_RS26780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M446_RS26785	COG3750	Belongs to the UPF0335 family
M446_RS26790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M446_RS26885	COG4957	zinc ion binding
M446_RS26910	COG0598	Magnesium transport protein CorA
M446_RS26925	COG0025	NhaP-type Na H and K H
M446_RS26960	COG0459	protein refolding
M446_RS26965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M446_RS26970	COG3920	Histidine kinase
M446_RS26970	COG2202	Pas domain
M446_RS26975	COG2202	Pas domain
M446_RS26975	COG3920	Histidine kinase
M446_RS26980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS26980	COG4191	Histidine kinase
M446_RS26995	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS27075	COG0745	RESPONSE REGULATOR receiver
M446_RS27090	COG2851	Citrate transporter
M446_RS27095	COG0583	DNA-binding transcription factor activity
M446_RS27105	COG3335	DDE superfamily endonuclease
M446_RS27110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M446_RS27110	COG1017	nitric oxide dioxygenase activity
M446_RS27135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M446_RS27145	COG0277	FAD linked oxidase domain protein
M446_RS27145	COG0247	lactate metabolic process
M446_RS27175	COG0604	alcohol dehydrogenase
M446_RS27175	COG3321	synthase
M446_RS27175	COG4221	oxidoreductase activity
M446_RS27175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M446_RS27190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M446_RS27200	COG4221	oxidoreductase activity
M446_RS27255	COG1309	transcriptional regulator
M446_RS27290	COG1755	Isoprenylcysteine carboxyl methyltransferase
M446_RS27315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M446_RS27320	COG0604	alcohol dehydrogenase
M446_RS27330	COG3002	Belongs to the UPF0753 family
M446_RS27335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M446_RS27360	COG1252	NADH dehydrogenase
M446_RS27375	COG2151	metal-sulfur cluster biosynthetic enzyme
M446_RS27385	COG0521	Mo-molybdopterin cofactor biosynthetic process
M446_RS27390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M446_RS27395	COG0288	reversible hydration of carbon dioxide
M446_RS27415	COG2181	nitrate reductase activity
M446_RS27420	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M446_RS27425	COG1140	nitrate reductase beta subunit
M446_RS27430	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M446_RS27455	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M446_RS27470	COG0411	ABC transporter
M446_RS27505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M446_RS27510	COG1846	Transcriptional regulator
M446_RS27530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M446_RS27630	COG1253	flavin adenine dinucleotide binding
M446_RS27640	COG3546	catalase activity
M446_RS27665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M446_RS27670	COG1845	cytochrome c oxidase, subunit III
M446_RS27675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M446_RS27680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M446_RS27685	COG0477	Major facilitator Superfamily
M446_RS27740	COG2154	pterin-4-alpha-carbinolamine dehydratase
M446_RS27785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M446_RS27790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M446_RS27795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M446_RS27810	COG2205	protein histidine kinase activity
M446_RS27815	COG0745	RESPONSE REGULATOR receiver
M446_RS27830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M446_RS27835	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M446_RS27840	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M446_RS27845	COG0535	radical SAM domain protein
M446_RS27875	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
M446_RS27880	COG1229	Formylmethanofuran dehydrogenase subunit A
M446_RS27885	COG1029	Formylmethanofuran dehydrogenase, subunit B
M446_RS27895	COG0702	epimerase
M446_RS27905	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
M446_RS27910	COG0189	ligase activity
M446_RS27920	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
M446_RS27930	COG3210	domain, Protein
M446_RS27940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M446_RS27950	COG5001	Diguanylate cyclase
M446_RS27960	COG0784	Response regulator, receiver
M446_RS27960	COG4191	Histidine kinase
M446_RS28010	COG0179	Fumarylacetoacetate (FAA) hydrolase
M446_RS28030	COG0436	Aminotransferase
M446_RS28070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M446_RS28120	COG0437	4 iron, 4 sulfur cluster binding
M446_RS28135	COG0437	4 iron, 4 sulfur cluster binding
M446_RS28150	COG3383	formate dehydrogenase (NAD+) activity
M446_RS28150	COG0243	molybdopterin cofactor binding
M446_RS28170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M446_RS28175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M446_RS28180	COG1088	dTDP-glucose 4,6-dehydratase activity
M446_RS28185	COG1091	dTDP-4-dehydrorhamnose reductase activity
M446_RS28190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M446_RS28195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M446_RS28200	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M446_RS28210	COG0860	N-Acetylmuramoyl-L-alanine amidase
M446_RS28215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M446_RS28235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M446_RS28250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M446_RS28270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M446_RS28290	COG2271	Major facilitator Superfamily
M446_RS28295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M446_RS28305	COG1840	ABC-type Fe3 transport system, periplasmic component
M446_RS28310	COG3842	ATPase activity
M446_RS28325	COG0463	Glycosyl transferase, family 2
M446_RS28340	COG0259	pyridoxamine-phosphate oxidase activity
M446_RS28345	COG0626	cystathionine gamma-synthase activity
M446_RS28350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M446_RS28355	COG4597	amino acid ABC transporter
M446_RS28360	COG0765	amino acid transport
M446_RS28365	COG1126	abc transporter atp-binding protein
M446_RS28370	COG2897	thiosulfate sulfurtransferase activity
M446_RS28395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M446_RS28410	COG0525	valine-tRNA ligase activity
M446_RS28440	COG1742	UPF0060 membrane protein
M446_RS28445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M446_RS28470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M446_RS28475	COG0148	phosphopyruvate hydratase activity
M446_RS28480	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M446_RS28485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M446_RS28490	COG0508	dehydrogenase complex catalyzes the overall conversion of
M446_RS28490	COG0022	dehydrogenase e1 component
M446_RS28505	COG0508	dehydrogenase complex catalyzes the overall conversion of
M446_RS28510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M446_RS28565	COG2226	methyltransferase
M446_RS28605	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M446_RS28620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M446_RS28625	COG2867	negative regulation of translational initiation
M446_RS28630	COG1546	Belongs to the CinA family
M446_RS28630	COG1058	Belongs to the CinA family
M446_RS28635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M446_RS28635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M446_RS28650	COG2204	response regulator
M446_RS28660	COG4957	zinc ion binding
M446_RS28670	COG1999	signal sequence binding
M446_RS28690	COG1595	DNA-templated transcription, initiation
M446_RS28695	COG5000	phosphorelay sensor kinase activity
M446_RS28700	COG2204	response regulator
M446_RS28705	COG1923	regulation of RNA biosynthetic process
M446_RS28710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M446_RS28725	COG0753	catalase activity
M446_RS28730	COG3956	TIGRFAM MazG family protein
M446_RS28775	COG3567	Phage-associated protein, HI1409 family
M446_RS28845	COG1392	Phosphate transport regulator
M446_RS28850	COG0306	phosphate transporter
M446_RS28895	COG0746	molybdenum cofactor guanylyltransferase activity
M446_RS28910	COG2304	oxidoreductase activity
M446_RS28920	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS28925	COG0165	Argininosuccinate lyase
M446_RS28930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M446_RS28935	COG1598	PFAM Uncharacterised protein family UPF0150
M446_RS28940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M446_RS28970	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS28970	COG1388	LysM domain
M446_RS28995	COG0126	phosphoglycerate kinase activity
M446_RS29005	COG0352	thiamine-phosphate diphosphorylase activity
M446_RS29015	COG0483	inositol monophosphate 1-phosphatase activity
M446_RS29020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M446_RS29035	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS29040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS29050	COG2205	protein histidine kinase activity
M446_RS29055	COG0745	RESPONSE REGULATOR receiver
M446_RS29060	COG1846	Transcriptional regulator
M446_RS29065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M446_RS29080	COG0583	DNA-binding transcription factor activity
M446_RS29095	COG0475	glutathione-regulated potassium exporter activity
M446_RS29095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M446_RS29105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M446_RS29110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M446_RS29115	COG2814	Major facilitator Superfamily
M446_RS29125	COG1802	Transcriptional regulator
M446_RS29130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M446_RS29150	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS29205	COG3220	belongs to the UPF0276 family
M446_RS29245	COG0742	ribosomal rna small subunit methyltransferase
M446_RS29250	COG1187	pseudouridine synthase activity
M446_RS29255	COG0590	tRNA wobble adenosine to inosine editing
M446_RS29260	COG0596	Alpha beta hydrolase
M446_RS29265	COG1914	H( )-stimulated, divalent metal cation uptake system
M446_RS29270	COG1305	Transglutaminase-like
M446_RS29275	COG0596	Alpha beta hydrolase
M446_RS29280	COG0151	Belongs to the GarS family
M446_RS29285	COG0408	coproporphyrinogen oxidase activity
M446_RS29295	COG0633	Ferredoxin
M446_RS29310	COG1570	exodeoxyribonuclease VII activity
M446_RS29340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M446_RS29350	COG0539	negative regulation of cytoplasmic translation
M446_RS29365	COG0318	PFAM AMP-dependent synthetase and ligase
M446_RS29370	COG1032	radical SAM domain protein
M446_RS29395	COG2954	triphosphatase activity
M446_RS29405	COG0297	glycogen (starch) synthase activity
M446_RS29430	COG3206	protein involved in exopolysaccharide biosynthesis
M446_RS29430	COG0489	protein tyrosine kinase activity
M446_RS29435	COG0438	transferase activity, transferring glycosyl groups
M446_RS29450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M446_RS29460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M446_RS29470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M446_RS29490	COG0071	Belongs to the small heat shock protein (HSP20) family
M446_RS29505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS29510	COG4566	intracellular signal transduction
M446_RS29515	COG4566	intracellular signal transduction
M446_RS29520	COG4191	Histidine kinase
M446_RS29525	COG3209	COG3209 Rhs family protein
M446_RS29550	COG0709	Synthesizes selenophosphate from selenide and ATP
M446_RS29555	COG0840	transmembrane signaling receptor activity
M446_RS29595	COG0137	argininosuccinate synthase activity
M446_RS29615	COG0259	pyridoxamine-phosphate oxidase activity
M446_RS29635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS29715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M446_RS29815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M446_RS29825	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS29835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M446_RS29840	COG0242	peptide deformylase activity
M446_RS29850	COG3773	Cell wall hydrolase
M446_RS29850	COG3409	Peptidoglycan-binding domain 1 protein
M446_RS29885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M446_RS29900	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M446_RS29905	COG2818	Glycosylase
M446_RS29915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M446_RS29920	COG2084	Dehydrogenase
M446_RS29945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M446_RS30010	COG0583	DNA-binding transcription factor activity
M446_RS30025	COG2084	Dehydrogenase
M446_RS30075	COG3106	COG3106 Predicted ATPase
M446_RS30080	COG3768	UPF0283 membrane protein
M446_RS30090	COG3549	Plasmid maintenance system killer
M446_RS30105	COG0667	Aldo Keto reductase
M446_RS30115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M446_RS30120	COG1132	(ABC) transporter
M446_RS30140	COG0416	fatty acid biosynthetic process
M446_RS30145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M446_RS30150	COG0776	regulation of translation
M446_RS30170	COG2766	serine protein kinase
M446_RS30175	COG2718	Belongs to the UPF0229 family
M446_RS30180	COG2719	SpoVR family
M446_RS30200	COG1620	l-lactate permease
M446_RS30210	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS30215	COG0583	DNA-binding transcription factor activity
M446_RS30235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M446_RS30245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M446_RS30250	COG2226	methyltransferase
M446_RS30260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M446_RS30335	COG1678	Uncharacterized ACR, COG1678
M446_RS30345	COG0443	Heat shock 70 kDa protein
M446_RS30350	COG0484	heat shock protein binding
M446_RS30355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M446_RS30375	COG1686	Belongs to the peptidase S11 family
M446_RS30380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M446_RS30385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M446_RS30395	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS30400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M446_RS30405	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M446_RS30435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M446_RS30440	COG0697	spore germination
M446_RS30455	COG0778	Nitroreductase
M446_RS30460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M446_RS30475	COG4957	zinc ion binding
M446_RS30480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M446_RS30485	COG0508	dehydrogenase complex catalyzes the overall conversion of
M446_RS30490	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M446_RS30525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M446_RS30530	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M446_RS30535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M446_RS30560	COG2301	Belongs to the HpcH HpaI aldolase family
M446_RS30580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M446_RS30585	COG0302	gtp cyclohydrolase
M446_RS30595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M446_RS30600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M446_RS30605	COG2824	Alkylphosphonate utilization operon protein PhnA
M446_RS30640	COG0625	glutathione transferase activity
M446_RS30685	COG3394	polysaccharide catabolic process
M446_RS30695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M446_RS30710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M446_RS30715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M446_RS30720	COG1657	PFAM Prenyltransferase squalene oxidase
M446_RS30725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M446_RS30730	COG1562	ergosterol biosynthetic process
M446_RS30735	COG1562	ergosterol biosynthetic process
M446_RS30740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M446_RS30745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M446_RS30790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M446_RS30800	COG0415	Belongs to the DNA photolyase family
M446_RS30810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M446_RS30815	COG1192	Involved in chromosome partitioning
M446_RS30845	COG1704	LemA family
M446_RS30850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M446_RS30865	COG1752	Esterase of the alpha-beta hydrolase superfamily
M446_RS30880	COG3842	ATPase activity
M446_RS30885	COG1176	ABC-type spermidine putrescine transport system, permease component I
M446_RS30890	COG1177	transmembrane transport
M446_RS30915	COG0729	surface antigen
M446_RS30920	COG0123	including yeast histone deacetylase and acetoin utilization protein
M446_RS30930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M446_RS30940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M446_RS30945	COG1722	exodeoxyribonuclease VII activity
M446_RS30955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M446_RS30970	COG1309	transcriptional regulator
M446_RS30995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS31005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M446_RS31045	COG2801	Transposase and inactivated derivatives
M446_RS31060	COG0784	Response regulator, receiver
M446_RS31060	COG4191	Histidine kinase
M446_RS31080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M446_RS31085	COG2020	methyltransferase activity
M446_RS31100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M446_RS31100	COG3620	sequence-specific DNA binding
M446_RS31100	COG0617	tRNA 3'-terminal CCA addition
M446_RS31105	COG2223	nitrite transmembrane transporter activity
M446_RS31110	COG0583	DNA-binding transcription factor activity
M446_RS31115	COG1027	Aspartate ammonia-lyase
M446_RS31120	COG1301	dicarboxylic acid transport
M446_RS31135	COG1595	DNA-templated transcription, initiation
M446_RS31150	COG0243	molybdopterin cofactor binding
M446_RS31165	COG5002	protein histidine kinase activity
M446_RS31165	COG0784	Response regulator, receiver
M446_RS31175	COG4191	Histidine kinase
M446_RS31175	COG0784	Response regulator, receiver
M446_RS31180	COG0784	Response regulator, receiver
M446_RS31180	COG4191	Histidine kinase
M446_RS31205	COG2855	membrane
M446_RS31225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M446_RS31230	COG1785	Belongs to the alkaline phosphatase family
M446_RS31240	COG1136	(ABC) transporter
M446_RS31265	COG3685	Protein conserved in bacteria
M446_RS31275	COG0321	lipoyl(octanoyl) transferase activity
M446_RS31275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M446_RS31280	COG0084	hydrolase, TatD family'
M446_RS31305	COG0438	transferase activity, transferring glycosyl groups
M446_RS31325	COG0747	negative chemotaxis
M446_RS31330	COG0601	transmembrane transport
M446_RS31335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M446_RS31355	COG4946	Tricorn protease homolog
M446_RS31355	COG1506	peptidase
M446_RS31355	COG0823	Involved in the tonB-independent uptake of proteins
M446_RS31360	COG0513	Belongs to the DEAD box helicase family
M446_RS31370	COG2271	Major facilitator Superfamily
M446_RS31380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M446_RS31460	COG4786	Flagellar basal body rod
M446_RS31465	COG1157	protein secretion by the type III secretion system
M446_RS31470	COG1749	Flagellar hook protein flgE
M446_RS31490	COG5443	negative regulation of bacterial-type flagellum assembly
M446_RS31495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M446_RS31515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M446_RS31550	COG0028	Belongs to the TPP enzyme family
M446_RS31570	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS31590	COG1607	acyl-coa hydrolase
M446_RS31595	COG2211	Major facilitator Superfamily
M446_RS31600	COG2202	Pas domain
M446_RS31600	COG3920	Histidine kinase
M446_RS31605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M446_RS31615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M446_RS31620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M446_RS31630	COG0584	glycerophosphoryl diester phosphodiesterase
M446_RS31635	COG0717	Belongs to the dCTP deaminase family
M446_RS31640	COG2967	ApaG domain
M446_RS31655	COG1280	lysine exporter protein (LysE YggA)
M446_RS31675	COG0281	malic enzyme
M446_RS31675	COG0280	phosphate acetyltransferase
M446_RS31680	COG1643	Atp-dependent helicase
M446_RS31685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M446_RS31690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M446_RS31715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M446_RS31720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M446_RS31725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M446_RS31730	COG3404	Formiminotransferase-cyclodeaminase
M446_RS31735	COG0045	succinate-CoA ligase (ADP-forming) activity
M446_RS31740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M446_RS31745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M446_RS31765	COG1309	transcriptional regulator
M446_RS31775	COG2172	sigma factor antagonist activity
M446_RS31780	COG2172	sigma factor antagonist activity
M446_RS31785	COG1366	Belongs to the anti-sigma-factor antagonist family
M446_RS31790	COG1366	Belongs to the anti-sigma-factor antagonist family
M446_RS31800	COG1285	pathogenesis
M446_RS31805	COG0697	spore germination
M446_RS31820	COG0488	(ABC) transporter
M446_RS31830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M446_RS31835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M446_RS31840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M446_RS31850	COG0217	transcriptional regulatory protein
M446_RS31855	COG4957	zinc ion binding
M446_RS31870	COG0544	peptidyl-prolyl cis-trans isomerase activity
M446_RS31875	COG0740	serine-type endopeptidase activity
M446_RS31880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M446_RS31885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M446_RS31890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M446_RS31890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M446_RS31895	COG0347	Belongs to the P(II) protein family
M446_RS31900	COG0174	glutamine synthetase
M446_RS31925	COG1686	Belongs to the peptidase S11 family
M446_RS31930	COG0602	queuosine metabolic process
M446_RS31935	COG0720	synthase
M446_RS31945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M446_RS31950	COG0183	Belongs to the thiolase family
M446_RS31955	COG2721	sulfolactate sulfo-lyase activity
M446_RS31960	COG0477	Major facilitator Superfamily
M446_RS31965	COG2176	DNA-directed DNA polymerase activity
M446_RS31975	COG4957	zinc ion binding
M446_RS31980	COG1388	LysM domain
M446_RS31980	COG1376	ErfK ybiS ycfS ynhG family protein
M446_RS32000	COG1505	serine-type exopeptidase activity
M446_RS32010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M446_RS32015	COG0577	efflux transmembrane transporter activity
M446_RS32015	COG1136	(ABC) transporter
M446_RS32025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M446_RS32030	COG0571	ribonuclease III activity
M446_RS32035	COG0681	Belongs to the peptidase S26 family
M446_RS32040	COG0736	holo-[acyl-carrier-protein] synthase activity
M446_RS32045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M446_RS32060	COG1132	(ABC) transporter
M446_RS32065	COG1573	uracil-dna glycosylase
M446_RS32080	COG0673	inositol 2-dehydrogenase activity
M446_RS32085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M446_RS32100	COG4232	protein-disulfide reductase activity
M446_RS32115	COG1051	belongs to the nudix hydrolase family
M446_RS32120	COG0288	reversible hydration of carbon dioxide
M446_RS32130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M446_RS32135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M446_RS32140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M446_RS32145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M446_RS32150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M446_RS32165	COG0137	argininosuccinate synthase activity
M446_RS32190	COG0473	3-isopropylmalate dehydrogenase activity
M446_RS32195	COG0025	NhaP-type Na H and K H
M446_RS32245	COG2354	Protein conserved in bacteria
M446_RS32250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M446_RS32265	COG1175	transmembrane transport
M446_RS32280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M446_RS32315	COG0557	exoribonuclease II activity
M446_RS32335	COG0477	Major facilitator Superfamily
M446_RS32340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M446_RS32355	COG0784	Response regulator, receiver
M446_RS32365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M446_RS32380	COG0745	RESPONSE REGULATOR receiver
M446_RS32385	COG0704	Plays a role in the regulation of phosphate uptake
M446_RS32390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M446_RS32395	COG0581	inorganic phosphate transmembrane transporter activity
M446_RS32400	COG0573	inorganic phosphate transmembrane transporter activity
M446_RS32405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M446_RS32425	COG0497	DNA recombination
M446_RS32430	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M446_RS32440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M446_RS32445	COG0849	cell division
M446_RS32450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M446_RS32470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M446_RS32475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M446_RS32485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M446_RS32490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M446_RS32495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M446_RS32500	COG0363	glucosamine-6-phosphate deaminase activity
M446_RS32520	COG2217	Heavy metal translocating P-type atpase
M446_RS32535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M446_RS32565	COG0582	viral genome integration into host DNA
M446_RS32605	COG2801	Transposase and inactivated derivatives
M446_RS32610	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS32645	COG4957	zinc ion binding
M446_RS32655	COG4957	zinc ion binding
M446_RS32680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M446_RS32690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M446_RS32695	COG3119	arylsulfatase activity
M446_RS32715	COG3328	transposase activity
M446_RS32730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M446_RS32745	COG0024	Methionine aminopeptidase
M446_RS32750	COG2003	Belongs to the UPF0758 family
M446_RS32755	COG2308	Evidence 4 Homologs of previously reported genes of
M446_RS32775	COG0352	thiamine-phosphate diphosphorylase activity
M446_RS32780	COG2022	thiamine diphosphate biosynthetic process
M446_RS32790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M446_RS32790	COG2022	thiamine diphosphate biosynthetic process
M446_RS32810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M446_RS32825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M446_RS32835	COG4585	Histidine kinase
M446_RS32875	COG1072	(Pantothenic acid kinase))
M446_RS32880	COG0140	phosphoribosyl-ATP diphosphatase activity
M446_RS32885	COG0107	imidazoleglycerol-phosphate synthase activity
M446_RS32890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M446_RS32895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M446_RS32905	COG0131	Imidazoleglycerol-phosphate dehydratase
M446_RS32910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M446_RS32915	COG2857	Cytochrome c1
M446_RS32915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M446_RS32920	COG2857	Cytochrome c1
M446_RS32920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M446_RS32935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M446_RS32945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M446_RS32950	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M446_RS32955	COG0243	molybdopterin cofactor binding
M446_RS32960	COG0436	Aminotransferase
M446_RS32965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M446_RS32970	COG0366	Alpha amylase catalytic
M446_RS32975	COG0366	Alpha amylase catalytic
M446_RS32985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M446_RS33000	COG1012	belongs to the aldehyde dehydrogenase family
M446_RS33005	COG3284	Transcriptional regulator
M446_RS33045	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M446_RS33050	COG0583	DNA-binding transcription factor activity
M446_RS33075	COG1519	Transferase
M446_RS33080	COG1663	tetraacyldisaccharide 4'-kinase activity
M446_RS33090	COG1846	Transcriptional regulator
M446_RS33100	COG1024	Enoyl-CoA hydratase
M446_RS33105	COG0113	porphobilinogen synthase activity
M446_RS33115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M446_RS33125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M446_RS33145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M446_RS33160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M446_RS33170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M446_RS33175	COG0564	pseudouridine synthase activity
M446_RS33195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M446_RS33200	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M446_RS33220	COG3052	prosthetic group binding
M446_RS33240	COG1802	Transcriptional regulator
M446_RS33285	COG2814	Major facilitator Superfamily
M446_RS33295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M446_RS33335	COG3335	DDE superfamily endonuclease
M446_RS33340	COG3415	Transposase
M446_RS33410	COG4957	zinc ion binding
M446_RS33470	COG2826	transposase and inactivated derivatives, IS30 family
M446_RS33495	COG3293	Transposase
M446_RS33530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS33600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M446_RS33605	COG1196	nuclear chromosome segregation
M446_RS33615	COG0356	it plays a direct role in the translocation of protons across the membrane
M446_RS33625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M446_RS33630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M446_RS33640	COG0596	Alpha beta hydrolase
M446_RS33650	COG1489	DNA binding
M446_RS33655	COG1058	Belongs to the CinA family
M446_RS33655	COG1546	Belongs to the CinA family
M446_RS33660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M446_RS33670	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS33710	COG0268	Binds directly to 16S ribosomal RNA
M446_RS33745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M446_RS33895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M446_RS34110	COG1404	Belongs to the peptidase S8 family
M446_RS34130	COG0463	Glycosyl transferase, family 2
M446_RS34160	COG3300	MHYT domain
M446_RS34160	COG5001	Diguanylate cyclase
M446_RS34200	COG4566	intracellular signal transduction
M446_RS34220	COG2190	(PTS) system
M446_RS34245	COG1131	(ABC) transporter
M446_RS34255	COG3153	acetyltransferase
M446_RS34290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M446_RS34335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M446_RS34350	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS34355	COG1028	Short-chain dehydrogenase reductase Sdr
M446_RS34365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M446_RS34400	COG2202	Pas domain
M446_RS34400	COG3920	Histidine kinase