locus-tag	class	description
Y590_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y590_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Y590_RS00020	COG0514	ATP-dependent DNA helicase (RecQ)
Y590_RS00030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y590_RS00040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y590_RS00055	COG0492	ferredoxin-NADP+ reductase activity
Y590_RS00125	COG4191	Histidine kinase
Y590_RS00125	COG0784	Response regulator, receiver
Y590_RS00130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Y590_RS00140	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS00145	COG1802	Transcriptional regulator
Y590_RS00165	COG3052	prosthetic group binding
Y590_RS00185	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Y590_RS00210	COG0135	phosphoribosylanthranilate isomerase activity
Y590_RS00220	COG0776	regulation of translation
Y590_RS00225	COG0616	signal peptide processing
Y590_RS00235	COG0539	negative regulation of cytoplasmic translation
Y590_RS00240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y590_RS00270	COG0328	RNA-DNA hybrid ribonuclease activity
Y590_RS00285	COG2814	Major facilitator Superfamily
Y590_RS00300	COG0583	DNA-binding transcription factor activity
Y590_RS00335	COG0785	Cytochrome C biogenesis protein
Y590_RS00360	COG0488	(ABC) transporter
Y590_RS00400	COG0438	transferase activity, transferring glycosyl groups
Y590_RS00405	COG1216	Glycosyl transferase, family 2
Y590_RS00420	COG0438	transferase activity, transferring glycosyl groups
Y590_RS00445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Y590_RS00475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y590_RS00480	COG0277	FAD linked oxidase domain protein
Y590_RS00495	COG0725	ABC transporter, periplasmic molybdate-binding protein
Y590_RS00540	COG1902	pentaerythritol trinitrate reductase activity
Y590_RS00560	COG3118	belongs to the thioredoxin family
Y590_RS00575	COG3548	integral membrane protein
Y590_RS00580	COG0459	protein refolding
Y590_RS00585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Y590_RS00605	COG4957	zinc ion binding
Y590_RS00615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y590_RS00630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Y590_RS00630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Y590_RS00635	COG0443	Heat shock 70 kDa protein
Y590_RS00640	COG0542	response to heat
Y590_RS00645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Y590_RS00660	COG0071	Belongs to the small heat shock protein (HSP20) family
Y590_RS00780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y590_RS00785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Y590_RS00790	COG0443	Heat shock 70 kDa protein
Y590_RS00800	COG0546	phosphoglycolate phosphatase activity
Y590_RS00810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Y590_RS00825	COG1309	transcriptional regulator
Y590_RS00830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Y590_RS00845	COG0604	alcohol dehydrogenase
Y590_RS00850	COG0753	catalase activity
Y590_RS00855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y590_RS00855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y590_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS00870	COG0640	Transcriptional regulator
Y590_RS00875	COG0180	Tryptophanyl-tRNA synthetase
Y590_RS00880	COG0066	3-isopropylmalate dehydratase activity
Y590_RS00885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Y590_RS00890	COG1703	isobutyryl-CoA mutase activity
Y590_RS00910	COG1388	LysM domain
Y590_RS00910	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS00920	COG0420	3'-5' exonuclease activity
Y590_RS00925	COG0419	ATPase involved in DNA repair
Y590_RS00930	COG2223	nitrite transmembrane transporter activity
Y590_RS00935	COG1040	competence protein
Y590_RS00945	COG2226	methyltransferase
Y590_RS00960	COG0494	nUDIX hydrolase
Y590_RS00970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Y590_RS01015	COG0210	DNA helicase
Y590_RS01035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Y590_RS01040	COG0840	transmembrane signaling receptor activity
Y590_RS01065	COG0745	RESPONSE REGULATOR receiver
Y590_RS01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS01085	COG1280	lysine exporter protein (LysE YggA)
Y590_RS01095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Y590_RS01100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Y590_RS01105	COG0077	Prephenate dehydratase
Y590_RS01105	COG1605	Chorismate mutase
Y590_RS01110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Y590_RS01115	COG3474	cytochrome
Y590_RS01120	COG4166	transmembrane transport
Y590_RS01125	COG4166	transmembrane transport
Y590_RS01130	COG4174	ABC transporter (Permease)
Y590_RS01145	COG0463	Glycosyl transferase, family 2
Y590_RS01210	COG3237	CsbD-like
Y590_RS01225	COG3237	CsbD-like
Y590_RS01230	COG3237	CsbD-like
Y590_RS01235	COG3781	membrane
Y590_RS01240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y590_RS01245	COG2967	ApaG domain
Y590_RS01260	COG2116	formate transmembrane transporter activity
Y590_RS01265	COG1058	Belongs to the CinA family
Y590_RS01265	COG1546	Belongs to the CinA family
Y590_RS01280	COG0596	Alpha beta hydrolase
Y590_RS01290	COG0842	Transport permease protein
Y590_RS01295	COG1131	(ABC) transporter
Y590_RS01340	COG0243	molybdopterin cofactor binding
Y590_RS01340	COG3383	formate dehydrogenase (NAD+) activity
Y590_RS01345	COG0437	4 iron, 4 sulfur cluster binding
Y590_RS01405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Y590_RS01410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Y590_RS01415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y590_RS01425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Y590_RS01440	COG1732	Glycine betaine
Y590_RS01445	COG1174	glycine betaine transport
Y590_RS01450	COG1174	glycine betaine transport
Y590_RS01455	COG1335	isochorismatase
Y590_RS01460	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS01475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Y590_RS01500	COG0745	RESPONSE REGULATOR receiver
Y590_RS01505	COG0196	riboflavin kinase activity
Y590_RS01535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Y590_RS01540	COG1338	Plays a role in the flagellum-specific transport system
Y590_RS01545	COG2259	Doxx family
Y590_RS01565	COG4957	zinc ion binding
Y590_RS01580	COG2166	iron-sulfur cluster assembly
Y590_RS01585	COG3920	Histidine kinase
Y590_RS01610	COG0308	aminopeptidase N
Y590_RS01615	COG2202	Pas domain
Y590_RS01615	COG2205	protein histidine kinase activity
Y590_RS01625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Y590_RS01635	COG1324	tolerance protein
Y590_RS01640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Y590_RS01650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y590_RS01650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y590_RS01670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Y590_RS01680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Y590_RS01685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y590_RS01690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Y590_RS01705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y590_RS01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y590_RS01715	COG1129	ABC transporter
Y590_RS01715	COG0842	Transport permease protein
Y590_RS01720	COG0842	Transport permease protein
Y590_RS01760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y590_RS01785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Y590_RS01795	COG4208	sulfate ABC transporter
Y590_RS01800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Y590_RS01840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y590_RS01845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Y590_RS01855	COG0438	transferase activity, transferring glycosyl groups
Y590_RS01855	COG1216	Glycosyl transferase, family 2
Y590_RS01890	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Y590_RS01900	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y590_RS01905	COG0047	phosphoribosylformylglycinamidine synthase activity
Y590_RS01910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Y590_RS01915	COG0483	inositol monophosphate 1-phosphatase activity
Y590_RS01925	COG2022	thiamine diphosphate biosynthetic process
Y590_RS01935	COG2022	thiamine diphosphate biosynthetic process
Y590_RS01935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y590_RS01960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y590_RS01965	COG0358	DNA primase activity
Y590_RS01970	COG3386	PFAM SMP-30 Gluconolaconase
Y590_RS01980	COG1610	YqeY-like protein
Y590_RS01985	COG0505	Belongs to the CarA family
Y590_RS02005	COG1558	bacterial-type flagellum-dependent cell motility
Y590_RS02015	COG4786	Flagellar basal body rod
Y590_RS02025	COG1706	bacterial-type flagellum-dependent cell motility
Y590_RS02035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Y590_RS02045	COG1338	Plays a role in the flagellum-specific transport system
Y590_RS02095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y590_RS02100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y590_RS02105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y590_RS02125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Y590_RS02130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Y590_RS02185	COG0228	four-way junction DNA binding
Y590_RS02195	COG0840	transmembrane signaling receptor activity
Y590_RS02215	COG0336	Belongs to the RNA methyltransferase TrmD family
Y590_RS02220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Y590_RS02225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y590_RS02245	COG0534	Mate efflux family protein
Y590_RS02250	COG1132	(ABC) transporter
Y590_RS02255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Y590_RS02260	COG0840	transmembrane signaling receptor activity
Y590_RS02275	COG2268	Band 7 protein
Y590_RS02280	COG4774	siderophore transport
Y590_RS02285	COG0408	coproporphyrinogen oxidase activity
Y590_RS02290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y590_RS02300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y590_RS02330	COG4786	Flagellar basal body rod
Y590_RS02335	COG1157	protein secretion by the type III secretion system
Y590_RS02360	COG5443	negative regulation of bacterial-type flagellum assembly
Y590_RS02365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y590_RS02370	COG4794	Type iii secretion
Y590_RS02375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y590_RS02405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y590_RS02425	COG2205	protein histidine kinase activity
Y590_RS02435	COG1294	oxidase, subunit
Y590_RS02440	COG2271	Major facilitator Superfamily
Y590_RS02455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y590_RS02460	COG0840	transmembrane signaling receptor activity
Y590_RS02465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Y590_RS02490	COG0123	including yeast histone deacetylase and acetoin utilization protein
Y590_RS02530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y590_RS02530	COG0519	Catalyzes the synthesis of GMP from XMP
Y590_RS02535	COG0667	Aldo Keto reductase
Y590_RS02540	COG0662	Cupin 2, conserved barrel domain protein
Y590_RS02540	COG2207	Transcriptional regulator
Y590_RS02575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Y590_RS02585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Y590_RS02620	COG2801	Transposase and inactivated derivatives
Y590_RS02650	COG1216	Glycosyl transferase, family 2
Y590_RS02660	COG1525	nuclease
Y590_RS02690	COG0840	transmembrane signaling receptor activity
Y590_RS02845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y590_RS02880	COG0745	RESPONSE REGULATOR receiver
Y590_RS02890	COG0110	maltose O-acetyltransferase activity
Y590_RS02895	COG0281	malic enzyme
Y590_RS02895	COG0280	phosphate acetyltransferase
Y590_RS02930	COG2080	2 iron, 2 sulfur cluster binding
Y590_RS02935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Y590_RS02940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y590_RS02945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Y590_RS02955	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Y590_RS03000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y590_RS03015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y590_RS03015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y590_RS03020	COG0509	glycine decarboxylation via glycine cleavage system
Y590_RS03025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y590_RS03040	COG0791	NLP P60 protein
Y590_RS03060	COG0714	Associated with various cellular activities
Y590_RS03075	COG2304	oxidoreductase activity
Y590_RS03120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y590_RS03130	COG3920	Histidine kinase
Y590_RS03130	COG2202	Pas domain
Y590_RS03135	COG0318	PFAM AMP-dependent synthetase and ligase
Y590_RS03150	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Y590_RS03185	COG1278	Cold shock
Y590_RS03205	COG2814	Major facilitator Superfamily
Y590_RS03210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y590_RS03215	COG1127	ABC transporter
Y590_RS03230	COG0583	DNA-binding transcription factor activity
Y590_RS03240	COG0483	inositol monophosphate 1-phosphatase activity
Y590_RS03255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Y590_RS03330	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Y590_RS03335	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Y590_RS03340	COG2205	protein histidine kinase activity
Y590_RS03355	COG5001	Diguanylate cyclase
Y590_RS03370	COG0154	amidase activity
Y590_RS03395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Y590_RS03410	COG0277	FAD linked oxidase domain protein
Y590_RS03420	COG1846	Transcriptional regulator
Y590_RS03435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Y590_RS03440	COG2983	Belongs to the UPF0260 family
Y590_RS03465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Y590_RS03470	COG2094	Belongs to the DNA glycosylase MPG family
Y590_RS03475	COG0328	RNA-DNA hybrid ribonuclease activity
Y590_RS03495	COG0189	ligase activity
Y590_RS03500	COG0025	NhaP-type Na H and K H
Y590_RS03505	COG3023	N-Acetylmuramoyl-L-alanine amidase
Y590_RS03510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Y590_RS03535	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Y590_RS03545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y590_RS03560	COG0745	RESPONSE REGULATOR receiver
Y590_RS03570	COG1749	Flagellar hook protein flgE
Y590_RS03590	COG2890	protein-(glutamine-N5) methyltransferase activity
Y590_RS03595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Y590_RS03605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y590_RS03610	COG0527	aspartate kinase activity
Y590_RS03615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y590_RS03625	COG3321	synthase
Y590_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS03625	COG0604	alcohol dehydrogenase
Y590_RS03630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Y590_RS03635	COG2353	YceI-like domain
Y590_RS03640	COG0632	four-way junction helicase activity
Y590_RS03650	COG0784	Response regulator, receiver
Y590_RS03660	COG1959	2 iron, 2 sulfur cluster binding
Y590_RS03665	COG1017	nitric oxide dioxygenase activity
Y590_RS03665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y590_RS03680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Y590_RS03700	COG0583	DNA-binding transcription factor activity
Y590_RS03750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y590_RS03765	COG1982	Orn Lys Arg decarboxylase major
Y590_RS03775	COG0521	Mo-molybdopterin cofactor biosynthetic process
Y590_RS03780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y590_RS03805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y590_RS03810	COG5001	Diguanylate cyclase
Y590_RS03810	COG3300	MHYT domain
Y590_RS03825	COG0564	pseudouridine synthase activity
Y590_RS03845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y590_RS03940	COG1162	GTPase activity
Y590_RS03985	COG0739	heme binding
Y590_RS03995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y590_RS04010	COG0326	Molecular chaperone. Has ATPase activity
Y590_RS04025	COG2226	methyltransferase
Y590_RS04060	COG2875	Belongs to the precorrin methyltransferase family
Y590_RS04065	COG1797	cobyrinic acid a,c-diamide synthase activity
Y590_RS04070	COG1396	sequence-specific DNA binding
Y590_RS04080	COG2223	nitrite transmembrane transporter activity
Y590_RS04090	COG0735	belongs to the Fur family
Y590_RS04095	COG1121	(ABC) transporter
Y590_RS04115	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Y590_RS04140	COG1381	Involved in DNA repair and RecF pathway recombination
Y590_RS04145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Y590_RS04150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Y590_RS04155	COG0683	leucine binding
Y590_RS04165	COG3608	succinylglutamate desuccinylase aspartoacylase
Y590_RS04165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Y590_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS04195	COG3932	Exopolysaccharide synthesis, ExoD
Y590_RS04200	COG1136	(ABC) transporter
Y590_RS04210	COG0442	prolyl-tRNA aminoacylation
Y590_RS04220	COG0346	lactoylglutathione lyase activity
Y590_RS04235	COG1007	ATP synthesis coupled electron transport
Y590_RS04250	COG0713	ATP synthesis coupled electron transport
Y590_RS04260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y590_RS04265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Y590_RS04275	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Y590_RS04285	COG0649	NAD binding
Y590_RS04290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y590_RS04295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y590_RS04300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y590_RS04315	COG3794	PFAM blue (type 1) copper domain protein
Y590_RS04320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Y590_RS04325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y590_RS04345	COG0492	ferredoxin-NADP+ reductase activity
Y590_RS04355	COG0583	DNA-binding transcription factor activity
Y590_RS04360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Y590_RS04365	COG0511	ligase activity, forming carbon-carbon bonds
Y590_RS04375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Y590_RS04400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y590_RS04435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y590_RS04530	COG0848	biopolymer transport protein
Y590_RS04540	COG0612	Peptidase, M16
Y590_RS04545	COG0612	Peptidase, M16
Y590_RS04555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y590_RS04560	COG1280	lysine exporter protein (LysE YggA)
Y590_RS04565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Y590_RS04570	COG4178	(ABC) transporter
Y590_RS04575	COG4178	(ABC) transporter
Y590_RS04590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Y590_RS04595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y590_RS04645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Y590_RS04655	COG4977	sequence-specific DNA binding
Y590_RS04690	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y590_RS04695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS04700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS04705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS04705	COG1116	anion transmembrane transporter activity
Y590_RS04710	COG0492	ferredoxin-NADP+ reductase activity
Y590_RS04715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y590_RS04730	COG1278	Cold shock
Y590_RS04755	COG2202	Pas domain
Y590_RS04755	COG3920	Histidine kinase
Y590_RS04765	COG4716	Myosin-crossreactive antigen
Y590_RS04780	COG0830	nickel cation binding
Y590_RS04785	COG0831	urea catabolic process
Y590_RS04785	COG0832	Belongs to the urease beta subunit family
Y590_RS04790	COG0804	urea catabolic process
Y590_RS04795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y590_RS04800	COG0829	nickel cation binding
Y590_RS04835	COG4191	Histidine kinase
Y590_RS04885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Y590_RS04890	COG1802	Transcriptional regulator
Y590_RS04895	COG0523	cobalamin synthesis protein
Y590_RS04900	COG1686	Belongs to the peptidase S11 family
Y590_RS04905	COG0602	queuosine metabolic process
Y590_RS04920	COG0720	synthase
Y590_RS04925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Y590_RS04930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Y590_RS04960	COG0297	glycogen (starch) synthase activity
Y590_RS04965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y590_RS04980	COG0642	Histidine kinase
Y590_RS04985	COG0745	RESPONSE REGULATOR receiver
Y590_RS05010	COG1609	Transcriptional regulator
Y590_RS05025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Y590_RS05055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y590_RS05060	COG1403	HNH endonuclease
Y590_RS05065	COG3453	Protein conserved in bacteria
Y590_RS05065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y590_RS05070	COG0024	Methionine aminopeptidase
Y590_RS05085	COG3246	L-lysine catabolic process to acetate
Y590_RS05095	COG4191	Histidine kinase
Y590_RS05100	COG1116	anion transmembrane transporter activity
Y590_RS05105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS05110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS05115	COG0850	regulation of cytokinetic process
Y590_RS05125	COG1217	gtp-binding protein TYPA
Y590_RS05135	COG0850	regulation of cytokinetic process
Y590_RS05160	COG3386	PFAM SMP-30 Gluconolaconase
Y590_RS05165	COG3387	PFAM Glycoside hydrolase 15-related
Y590_RS05215	COG0410	ABC transporter
Y590_RS05225	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y590_RS05245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y590_RS05275	COG0596	Alpha beta hydrolase
Y590_RS05320	COG4227	nucleotidyltransferase activity
Y590_RS05325	COG4227	nucleotidyltransferase activity
Y590_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
Y590_RS05425	COG0723	plastoquinol--plastocyanin reductase activity
Y590_RS05440	COG3284	Transcriptional regulator
Y590_RS05470	COG0346	lactoylglutathione lyase activity
Y590_RS05485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Y590_RS05550	COG1215	transferase activity, transferring glycosyl groups
Y590_RS05560	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Y590_RS05600	COG2963	transposase activity
Y590_RS05620	COG0831	urea catabolic process
Y590_RS05630	COG0804	urea catabolic process
Y590_RS05650	COG0830	nickel cation binding
Y590_RS05655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y590_RS05660	COG0829	nickel cation binding
Y590_RS05670	COG0004	ammonium transporteR
Y590_RS05760	COG0589	response to stress
Y590_RS05770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y590_RS05775	COG2274	protein secretion by the type I secretion system
Y590_RS05780	COG4988	ABC transporter
Y590_RS05785	COG1271	oxidase subunit
Y590_RS05790	COG1294	oxidase, subunit
Y590_RS05795	COG1349	DNA-binding transcription factor activity
Y590_RS05800	COG0154	amidase activity
Y590_RS05815	COG1215	transferase activity, transferring glycosyl groups
Y590_RS05825	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Y590_RS06005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y590_RS06010	COG3275	phosphorelay sensor kinase activity
Y590_RS06030	COG1335	isochorismatase
Y590_RS06035	COG2814	Major facilitator Superfamily
Y590_RS06090	COG1999	signal sequence binding
Y590_RS06110	COG4423	Transcription factor
Y590_RS06125	COG1802	Transcriptional regulator
Y590_RS06130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Y590_RS06170	COG2373	Large extracellular alpha-helical protein
Y590_RS06175	COG4953	penicillin-binding protein 1C
Y590_RS06180	COG2076	Multidrug Resistance protein
Y590_RS06220	COG3088	subunit of a heme lyase
Y590_RS06225	COG1138	Cytochrome C-type biogenesis protein
Y590_RS06230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Y590_RS06235	COG4235	cytochrome complex assembly
Y590_RS06280	COG3772	lysozyme
Y590_RS06365	COG4695	Portal protein
Y590_RS06440	COG2202	Pas domain
Y590_RS06440	COG3920	Histidine kinase
Y590_RS06475	COG0840	transmembrane signaling receptor activity
Y590_RS06480	COG0784	Response regulator, receiver
Y590_RS06480	COG4191	Histidine kinase
Y590_RS06490	COG3708	Transcriptional regulator
Y590_RS06490	COG2207	Transcriptional regulator
Y590_RS06510	COG0714	Associated with various cellular activities
Y590_RS06525	COG0494	nUDIX hydrolase
Y590_RS06535	COG0617	tRNA 3'-terminal CCA addition
Y590_RS06540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Y590_RS06550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Y590_RS06555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Y590_RS06560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Y590_RS06570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Y590_RS06585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Y590_RS06600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y590_RS06625	COG1051	belongs to the nudix hydrolase family
Y590_RS06640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Y590_RS06645	COG0237	dephospho-CoA kinase activity
Y590_RS06650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Y590_RS06660	COG0424	maF-like protein
Y590_RS06670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Y590_RS06675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Y590_RS06685	COG1981	membrane
Y590_RS06695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Y590_RS06700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Y590_RS06735	COG0314	molybdopterin synthase activity
Y590_RS06745	COG0579	oxidoreductase
Y590_RS06760	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Y590_RS06770	COG0714	Associated with various cellular activities
Y590_RS06785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Y590_RS06790	COG1573	uracil-dna glycosylase
Y590_RS06800	COG0284	orotidine-5'-phosphate decarboxylase activity
Y590_RS06830	COG0494	nUDIX hydrolase
Y590_RS06835	COG0288	reversible hydration of carbon dioxide
Y590_RS06840	COG1218	3'(2'),5'-bisphosphate nucleotidase
Y590_RS06850	COG2198	Histidine kinase
Y590_RS06850	COG0784	Response regulator, receiver
Y590_RS06850	COG0643	Histidine kinase
Y590_RS06865	COG2201	protein-glutamate methylesterase activity
Y590_RS06880	COG1984	allophanate hydrolase subunit 2
Y590_RS06910	COG2096	Adenosyltransferase
Y590_RS06915	COG2086	electron transfer activity
Y590_RS06920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Y590_RS06925	COG1250	3-hydroxyacyl-CoA dehydrogenase
Y590_RS06935	COG0604	alcohol dehydrogenase
Y590_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS06935	COG3321	synthase
Y590_RS06940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Y590_RS06950	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Y590_RS06975	COG0124	histidyl-tRNA synthetase
Y590_RS06980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y590_RS06995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Y590_RS07015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Y590_RS07020	COG0028	Belongs to the TPP enzyme family
Y590_RS07030	COG1253	flavin adenine dinucleotide binding
Y590_RS07050	COG0671	phosphoesterase, PA-phosphatase related
Y590_RS07060	COG2171	N-acyltransferase activity
Y590_RS07070	COG0745	RESPONSE REGULATOR receiver
Y590_RS07090	COG0495	leucyl-tRNA aminoacylation
Y590_RS07095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Y590_RS07105	COG0445	tRNA wobble uridine modification
Y590_RS07150	COG0287	Prephenate dehydrogenase
Y590_RS07155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y590_RS07165	COG4774	siderophore transport
Y590_RS07170	COG3158	transport of potassium into the cell
Y590_RS07175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Y590_RS07185	COG2226	methyltransferase
Y590_RS07195	COG1410	methionine synthase
Y590_RS07195	COG0646	methionine synthase
Y590_RS07230	COG1612	heme a metabolic process
Y590_RS07235	COG1272	protein, Hemolysin III
Y590_RS07245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Y590_RS07270	COG5442	Flagellar protein FlaF
Y590_RS07295	COG0848	biopolymer transport protein
Y590_RS07325	COG0438	transferase activity, transferring glycosyl groups
Y590_RS07350	COG0438	transferase activity, transferring glycosyl groups
Y590_RS07355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Y590_RS07360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Y590_RS07365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Y590_RS07370	COG0072	phenylalanine-tRNA ligase activity
Y590_RS07370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y590_RS07375	COG0653	protein targeting
Y590_RS07385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y590_RS07395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y590_RS07400	COG0242	peptide deformylase activity
Y590_RS07410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Y590_RS07415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Y590_RS07420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Y590_RS07425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Y590_RS07435	COG0039	L-malate dehydrogenase activity
Y590_RS07440	COG0045	succinate-CoA ligase (ADP-forming) activity
Y590_RS07445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Y590_RS07455	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y590_RS07465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y590_RS07470	COG0784	Response regulator, receiver
Y590_RS07470	COG4191	Histidine kinase
Y590_RS07485	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y590_RS07485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y590_RS07495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y590_RS07505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Y590_RS07510	COG2218	PFAM glutamate synthase alpha subunit domain protein
Y590_RS07515	COG0069	glutamate synthase activity
Y590_RS07535	COG4372	Transposase
Y590_RS07585	COG2963	transposase activity
Y590_RS07605	COG2963	transposase activity
Y590_RS07615	COG2801	Transposase and inactivated derivatives
Y590_RS07630	COG3387	PFAM Glycoside hydrolase 15-related
Y590_RS07635	COG0402	S-adenosylhomocysteine deaminase activity
Y590_RS07645	COG0583	DNA-binding transcription factor activity
Y590_RS07655	COG2814	Major facilitator Superfamily
Y590_RS07665	COG2814	Major facilitator Superfamily
Y590_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS07675	COG4948	Mandelate Racemase Muconate Lactonizing
Y590_RS07680	COG3962	Belongs to the TPP enzyme family
Y590_RS07695	COG1414	Transcriptional regulator
Y590_RS07720	COG2010	Cytochrome c
Y590_RS07720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y590_RS07775	COG2233	PERMEase
Y590_RS07810	COG3845	ABC transporter
Y590_RS07835	COG1079	Belongs to the binding-protein-dependent transport system permease family
Y590_RS07840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y590_RS07850	COG3845	ABC transporter
Y590_RS07880	COG0583	DNA-binding transcription factor activity
Y590_RS07885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y590_RS07895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS07900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS07905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS07910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Y590_RS07915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Y590_RS07925	COG0251	oxidation-reduction process
Y590_RS07935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y590_RS07940	COG1309	transcriptional regulator
Y590_RS07945	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Y590_RS07950	COG3257	ureidoglycine aminohydrolase activity
Y590_RS07960	COG0583	DNA-binding transcription factor activity
Y590_RS07970	COG2351	hydroxyisourate hydrolase activity
Y590_RS07980	COG0457	Tetratricopeptide repeat
Y590_RS07980	COG0463	Glycosyl transferase, family 2
Y590_RS07995	COG2354	Protein conserved in bacteria
Y590_RS08000	COG5001	Diguanylate cyclase
Y590_RS08035	COG0405	Gamma-glutamyltransferase
Y590_RS08055	COG2813	Specifically methylates the guanine in position
Y590_RS08055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Y590_RS08060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Y590_RS08070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y590_RS08085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Y590_RS08110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Y590_RS08115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Y590_RS08120	COG3118	belongs to the thioredoxin family
Y590_RS08165	COG3106	COG3106 Predicted ATPase
Y590_RS08170	COG3768	UPF0283 membrane protein
Y590_RS08210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Y590_RS08215	COG0438	transferase activity, transferring glycosyl groups
Y590_RS08225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Y590_RS08230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y590_RS08235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Y590_RS08240	COG3404	Formiminotransferase-cyclodeaminase
Y590_RS08245	COG0045	succinate-CoA ligase (ADP-forming) activity
Y590_RS08250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Y590_RS08255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Y590_RS08265	COG0251	oxidation-reduction process
Y590_RS08270	COG1902	pentaerythritol trinitrate reductase activity
Y590_RS08275	COG0583	DNA-binding transcription factor activity
Y590_RS08280	COG0412	Dienelactone hydrolase
Y590_RS08285	COG2154	pterin-4-alpha-carbinolamine dehydratase
Y590_RS08320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Y590_RS08325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Y590_RS08330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Y590_RS08345	COG0535	radical SAM domain protein
Y590_RS08350	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Y590_RS08355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Y590_RS08370	COG2205	protein histidine kinase activity
Y590_RS08380	COG2218	PFAM glutamate synthase alpha subunit domain protein
Y590_RS08385	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Y590_RS08390	COG1229	Formylmethanofuran dehydrogenase subunit A
Y590_RS08395	COG1029	Formylmethanofuran dehydrogenase, subunit B
Y590_RS08405	COG0702	epimerase
Y590_RS08415	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Y590_RS08420	COG0189	ligase activity
Y590_RS08430	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Y590_RS08510	COG1131	(ABC) transporter
Y590_RS08540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Y590_RS08560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Y590_RS08585	COG0606	chelatase, subunit chli
Y590_RS08610	COG1607	acyl-coa hydrolase
Y590_RS08620	COG0741	lytic transglycosylase activity
Y590_RS08625	COG0243	molybdopterin cofactor binding
Y590_RS08630	COG4172	Belongs to the ABC transporter superfamily
Y590_RS08635	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Y590_RS08660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Y590_RS08665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS08670	COG1562	ergosterol biosynthetic process
Y590_RS08675	COG1562	ergosterol biosynthetic process
Y590_RS08680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Y590_RS08685	COG1657	PFAM Prenyltransferase squalene oxidase
Y590_RS08695	COG0156	8-amino-7-oxononanoate synthase activity
Y590_RS08700	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS08700	COG3321	synthase
Y590_RS08700	COG0604	alcohol dehydrogenase
Y590_RS08705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Y590_RS08710	COG0438	transferase activity, transferring glycosyl groups
Y590_RS08710	COG1216	Glycosyl transferase, family 2
Y590_RS08735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y590_RS08760	COG3646	Phage regulatory protein
Y590_RS08875	COG4974	Belongs to the 'phage' integrase family
Y590_RS08900	COG4303	Ethanolamine ammonia lyase large subunit
Y590_RS08905	COG4302	ethanolamine ammonia-lyase activity
Y590_RS08910	COG0129	dihydroxy-acid dehydratase activity
Y590_RS08950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Y590_RS08965	COG1494	fructose-1,6-bisphosphatase
Y590_RS09015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y590_RS09020	COG2264	protein methyltransferase activity
Y590_RS09040	COG1271	oxidase subunit
Y590_RS09050	COG3706	GGDEF domain
Y590_RS09065	COG0672	)-iron permease
Y590_RS09075	COG5328	Belongs to the UPF0262 family
Y590_RS09080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Y590_RS09095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Y590_RS09105	COG0156	8-amino-7-oxononanoate synthase activity
Y590_RS09120	COG2824	Alkylphosphonate utilization operon protein PhnA
Y590_RS09135	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Y590_RS09150	COG1561	YicC-like family, N-terminal region
Y590_RS09155	COG0194	GDP metabolic process
Y590_RS09160	COG1132	(ABC) transporter
Y590_RS09165	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS09170	COG0778	Nitroreductase
Y590_RS09180	COG4774	siderophore transport
Y590_RS09185	COG0800	Aldolase
Y590_RS09190	COG0129	dihydroxy-acid dehydratase activity
Y590_RS09230	COG2879	small protein
Y590_RS09235	COG1966	Carbon starvation protein
Y590_RS09245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Y590_RS09250	COG1704	LemA family
Y590_RS09260	COG5001	Diguanylate cyclase
Y590_RS09275	COG0297	glycogen (starch) synthase activity
Y590_RS09280	COG0366	Alpha amylase catalytic
Y590_RS09285	COG0058	SHG alpha-glucan phosphorylase activity
Y590_RS09305	COG5001	Diguanylate cyclase
Y590_RS09310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y590_RS09315	COG0702	epimerase
Y590_RS09320	COG1086	Polysaccharide biosynthesis protein
Y590_RS09365	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Y590_RS09375	COG1902	pentaerythritol trinitrate reductase activity
Y590_RS09380	COG0546	phosphoglycolate phosphatase activity
Y590_RS09400	COG0416	fatty acid biosynthetic process
Y590_RS09405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Y590_RS09410	COG0776	regulation of translation
Y590_RS09430	COG2766	serine protein kinase
Y590_RS09435	COG2718	Belongs to the UPF0229 family
Y590_RS09440	COG2719	SpoVR family
Y590_RS09445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Y590_RS09450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Y590_RS09455	COG0628	permease
Y590_RS09465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Y590_RS09480	COG0436	Aminotransferase
Y590_RS09495	COG0052	Belongs to the universal ribosomal protein uS2 family
Y590_RS09500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Y590_RS09505	COG0528	UMP kinase activity
Y590_RS09510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Y590_RS09530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y590_RS09535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y590_RS09540	COG0750	zinc metalloprotease
Y590_RS09545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Y590_RS09555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Y590_RS09560	COG0233	cytoplasmic translational termination
Y590_RS09570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y590_RS09575	COG0583	DNA-binding transcription factor activity
Y590_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS09585	COG3959	Transketolase, thiamine diphosphate binding domain
Y590_RS09590	COG3958	Transketolase
Y590_RS09595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Y590_RS09615	COG1946	Acyl-CoA thioesterase
Y590_RS09620	COG0347	Belongs to the P(II) protein family
Y590_RS09625	COG0004	ammonium transporteR
Y590_RS09645	COG3920	Histidine kinase
Y590_RS09655	COG0243	molybdopterin cofactor binding
Y590_RS09690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Y590_RS09695	COG1045	serine acetyltransferase
Y590_RS09700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y590_RS09705	COG0747	negative chemotaxis
Y590_RS09710	COG4191	Histidine kinase
Y590_RS09710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y590_RS09730	COG0784	Response regulator, receiver
Y590_RS09730	COG3437	response regulator, receiver
Y590_RS09745	COG0523	cobalamin synthesis protein
Y590_RS09780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Y590_RS09805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Y590_RS09825	COG1819	glycosyl
Y590_RS09835	COG5001	Diguanylate cyclase
Y590_RS09860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Y590_RS09865	COG0318	PFAM AMP-dependent synthetase and ligase
Y590_RS09895	COG1942	4-Oxalocrotonate Tautomerase
Y590_RS09910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y590_RS09925	COG0583	DNA-binding transcription factor activity
Y590_RS09930	COG0346	lactoylglutathione lyase activity
Y590_RS09935	COG0400	carboxylic ester hydrolase activity
Y590_RS09940	COG0456	acetyltransferase
Y590_RS09940	COG1846	Transcriptional regulator
Y590_RS09955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Y590_RS09960	COG0049	tRNA binding
Y590_RS09965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Y590_RS09970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y590_RS09975	COG0051	transcription antitermination factor activity, RNA binding
Y590_RS09980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Y590_RS09985	COG0088	Forms part of the polypeptide exit tunnel
Y590_RS09990	COG0089	rRNA binding
Y590_RS09995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Y590_RS10000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Y590_RS10005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Y590_RS10010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Y590_RS10015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Y590_RS10020	COG0255	Belongs to the universal ribosomal protein uL29 family
Y590_RS10025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Y590_RS10030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y590_RS10040	COG1846	Transcriptional regulator
Y590_RS10045	COG0203	ribosomal protein L17
Y590_RS10060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Y590_RS10065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Y590_RS10070	COG0563	adenylate kinase activity
Y590_RS10075	COG0201	protein transport
Y590_RS10080	COG0200	Binds to the 23S rRNA
Y590_RS10085	COG1841	ribosomal large subunit assembly
Y590_RS10090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Y590_RS10095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Y590_RS10100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Y590_RS10105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Y590_RS10110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Y590_RS10115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Y590_RS10120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Y590_RS10125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Y590_RS10145	COG5002	protein histidine kinase activity
Y590_RS10145	COG3447	MASE1 domain protein
Y590_RS10145	COG5001	Diguanylate cyclase
Y590_RS10185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y590_RS10200	COG0024	Methionine aminopeptidase
Y590_RS10205	COG2003	Belongs to the UPF0758 family
Y590_RS10210	COG2308	Evidence 4 Homologs of previously reported genes of
Y590_RS10220	COG0477	Major facilitator Superfamily
Y590_RS10235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Y590_RS10240	COG1253	flavin adenine dinucleotide binding
Y590_RS10260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y590_RS10290	COG3300	MHYT domain
Y590_RS10290	COG5001	Diguanylate cyclase
Y590_RS10320	COG0175	sulfate reduction
Y590_RS10325	COG0175	sulfate reduction
Y590_RS10330	COG1522	sequence-specific DNA binding
Y590_RS10335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Y590_RS10340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y590_RS10360	COG0629	single-stranded DNA binding
Y590_RS10365	COG2130	NADP-dependent
Y590_RS10380	COG3698	Phosphodiester glycosidase
Y590_RS10385	COG1902	pentaerythritol trinitrate reductase activity
Y590_RS10390	COG0435	Glutathione S-transferase
Y590_RS10400	COG3118	belongs to the thioredoxin family
Y590_RS10410	COG2835	tetraacyldisaccharide 4'-kinase activity
Y590_RS10420	COG0784	Response regulator, receiver
Y590_RS10420	COG4191	Histidine kinase
Y590_RS10455	COG2239	Acts as a magnesium transporter
Y590_RS10460	COG1752	Esterase of the alpha-beta hydrolase superfamily
Y590_RS10465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Y590_RS10470	COG0302	gtp cyclohydrolase
Y590_RS10480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Y590_RS10485	COG0670	Belongs to the BI1 family
Y590_RS10495	COG4191	Histidine kinase
Y590_RS10500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Y590_RS10510	COG0681	Belongs to the peptidase S26 family
Y590_RS10515	COG0571	ribonuclease III activity
Y590_RS10520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Y590_RS10530	COG1187	pseudouridine synthase activity
Y590_RS10565	COG3158	transport of potassium into the cell
Y590_RS10575	COG0494	nUDIX hydrolase
Y590_RS10600	COG0793	Belongs to the peptidase S41A family
Y590_RS10610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Y590_RS10620	COG5001	Diguanylate cyclase
Y590_RS10620	COG3300	MHYT domain
Y590_RS10630	COG0137	argininosuccinate synthase activity
Y590_RS10645	COG0546	phosphoglycolate phosphatase activity
Y590_RS10655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Y590_RS10680	COG2137	regulation of response to DNA damage stimulus
Y590_RS10685	COG1764	response to oxidative stress
Y590_RS10695	COG1573	uracil-dna glycosylase
Y590_RS10725	COG0625	glutathione transferase activity
Y590_RS10730	COG0753	catalase activity
Y590_RS10740	COG0778	Nitroreductase
Y590_RS10755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y590_RS10765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Y590_RS10775	COG1940	carbohydrate kinase activity
Y590_RS10780	COG1301	dicarboxylic acid transport
Y590_RS10785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Y590_RS10790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Y590_RS10800	COG0612	Peptidase, M16
Y590_RS10805	COG0612	Peptidase, M16
Y590_RS10810	COG0346	lactoylglutathione lyase activity
Y590_RS10825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Y590_RS10875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y590_RS10905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y590_RS10915	COG2031	fatty acid transporter
Y590_RS10925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Y590_RS10930	COG0706	membrane insertase activity
Y590_RS10935	COG0594	ribonuclease P activity
Y590_RS10940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Y590_RS10950	COG0254	rRNA binding
Y590_RS10955	COG1132	(ABC) transporter
Y590_RS10960	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Y590_RS10975	COG1692	metallophosphoesterase
Y590_RS10980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Y590_RS11010	COG0126	phosphoglycerate kinase activity
Y590_RS11030	COG0531	amino acid
Y590_RS11035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Y590_RS11035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Y590_RS11040	COG0347	Belongs to the P(II) protein family
Y590_RS11045	COG2066	Belongs to the glutaminase family
Y590_RS11050	COG0174	glutamine synthetase
Y590_RS11055	COG0174	glutamine synthetase
Y590_RS11060	COG3300	MHYT domain
Y590_RS11060	COG5001	Diguanylate cyclase
Y590_RS11065	COG0431	NADPH-dependent FMN reductase
Y590_RS11075	COG0557	exoribonuclease II activity
Y590_RS11105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Y590_RS11115	COG1968	undecaprenyl-diphosphatase activity
Y590_RS11140	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Y590_RS11145	COG1088	dTDP-glucose 4,6-dehydratase activity
Y590_RS11150	COG1091	dTDP-4-dehydrorhamnose reductase activity
Y590_RS11160	COG3161	chorismate lyase activity
Y590_RS11165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y590_RS11170	COG0653	protein targeting
Y590_RS11195	COG0572	uridine kinase
Y590_RS11235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Y590_RS11240	COG1032	radical SAM domain protein
Y590_RS11260	COG0544	peptidyl-prolyl cis-trans isomerase activity
Y590_RS11265	COG0740	serine-type endopeptidase activity
Y590_RS11270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Y590_RS11275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y590_RS11285	COG0438	transferase activity, transferring glycosyl groups
Y590_RS11295	COG2813	Specifically methylates the guanine in position
Y590_RS11310	COG1297	OPT oligopeptide transporter protein
Y590_RS11330	COG1295	ribonuclease BN
Y590_RS11340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y590_RS11340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y590_RS11345	COG1515	deoxyribonuclease V activity
Y590_RS11350	COG0012	GTP binding
Y590_RS11355	COG0193	aminoacyl-tRNA hydrolase activity
Y590_RS11385	COG4964	Belongs to the GSP D family
Y590_RS11420	COG0477	Major facilitator Superfamily
Y590_RS11425	COG1764	response to oxidative stress
Y590_RS11430	COG1832	CoA-binding protein
Y590_RS11445	COG5001	Diguanylate cyclase
Y590_RS11445	COG3706	GGDEF domain
Y590_RS11445	COG4251	negative regulation of phosphorylation
Y590_RS11445	COG2203	Gaf domain
Y590_RS11470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y590_RS11485	COG1137	ATPase activity
Y590_RS11490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Y590_RS11495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Y590_RS11500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y590_RS11520	COG0588	phosphoglycerate mutase activity
Y590_RS11525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Y590_RS11540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y590_RS11550	COG4974	Belongs to the 'phage' integrase family
Y590_RS11565	COG4239	(ABC) transporter, permease
Y590_RS11585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y590_RS11600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Y590_RS11605	COG0473	3-isopropylmalate dehydrogenase activity
Y590_RS11630	COG0142	geranyltranstransferase activity
Y590_RS11635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y590_RS11650	COG0415	Belongs to the DNA photolyase family
Y590_RS11655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Y590_RS11675	COG1368	sulfuric ester hydrolase activity
Y590_RS11695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y590_RS11705	COG0723	plastoquinol--plastocyanin reductase activity
Y590_RS11710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Y590_RS11710	COG2857	Cytochrome c1
Y590_RS11715	COG2857	Cytochrome c1
Y590_RS11715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Y590_RS11720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Y590_RS11745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Y590_RS11750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Y590_RS11755	COG0107	imidazoleglycerol-phosphate synthase activity
Y590_RS11760	COG0140	phosphoribosyl-ATP diphosphatase activity
Y590_RS11765	COG1072	(Pantothenic acid kinase))
Y590_RS11790	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS11790	COG1388	LysM domain
Y590_RS11810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Y590_RS11815	COG3162	membrane
Y590_RS11825	COG0138	bifunctional purine biosynthesis protein purh
Y590_RS11835	COG2897	thiosulfate sulfurtransferase activity
Y590_RS11845	COG0513	Belongs to the DEAD box helicase family
Y590_RS11865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y590_RS11885	COG1970	mechanosensitive ion channel activity
Y590_RS11900	COG0436	Aminotransferase
Y590_RS11915	COG0745	RESPONSE REGULATOR receiver
Y590_RS11920	COG1846	Transcriptional regulator
Y590_RS11925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y590_RS11950	COG0475	glutathione-regulated potassium exporter activity
Y590_RS11950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y590_RS11955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Y590_RS11960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Y590_RS11970	COG1678	Uncharacterized ACR, COG1678
Y590_RS11980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y590_RS11985	COG2378	regulation of single-species biofilm formation
Y590_RS11990	COG0625	glutathione transferase activity
Y590_RS11995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Y590_RS12010	COG1684	flagellar biosynthetic protein fliR
Y590_RS12015	COG1987	bacterial-type flagellum assembly
Y590_RS12020	COG1677	Flagellar hook-basal body complex protein FliE
Y590_RS12025	COG1558	bacterial-type flagellum-dependent cell motility
Y590_RS12040	COG0579	oxidoreductase
Y590_RS12050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y590_RS12060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y590_RS12065	COG0247	lactate metabolic process
Y590_RS12070	COG1139	Iron-sulfur cluster binding protein
Y590_RS12085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Y590_RS12090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y590_RS12110	COG1132	(ABC) transporter
Y590_RS12130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Y590_RS12135	COG0424	maF-like protein
Y590_RS12160	COG4774	siderophore transport
Y590_RS12175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y590_RS12180	COG4133	protoheme IX ABC transporter activity
Y590_RS12185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Y590_RS12200	COG2329	Antibiotic biosynthesis monooxygenase
Y590_RS12205	COG0625	glutathione transferase activity
Y590_RS12210	COG1252	NADH dehydrogenase
Y590_RS12225	COG0840	transmembrane signaling receptor activity
Y590_RS12235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Y590_RS12245	COG1388	LysM domain
Y590_RS12245	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS12260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Y590_RS12275	COG2084	Dehydrogenase
Y590_RS12280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Y590_RS12285	COG0560	Phosphoserine phosphatase
Y590_RS12295	COG0330	HflC and HflK could
Y590_RS12300	COG0330	HflC and HflK could
Y590_RS12330	COG2124	cytochrome p450
Y590_RS12335	COG0114	fumarate hydratase activity
Y590_RS12370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Y590_RS12375	COG0586	Pfam SNARE associated Golgi protein
Y590_RS12380	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Y590_RS12385	COG0384	phenazine biosynthesis protein PhzF
Y590_RS12400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Y590_RS12405	COG0129	dihydroxy-acid dehydratase activity
Y590_RS12415	COG4948	Mandelate Racemase Muconate Lactonizing
Y590_RS12440	COG0673	inositol 2-dehydrogenase activity
Y590_RS12455	COG0438	transferase activity, transferring glycosyl groups
Y590_RS12470	COG0392	lysyltransferase activity
Y590_RS12470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Y590_RS12475	COG5002	protein histidine kinase activity
Y590_RS12490	COG1473	amidohydrolase
Y590_RS12495	COG0840	transmembrane signaling receptor activity
Y590_RS12500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Y590_RS12505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Y590_RS12510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Y590_RS12525	COG0779	Required for maturation of 30S ribosomal subunits
Y590_RS12530	COG0110	maltose O-acetyltransferase activity
Y590_RS12535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y590_RS12550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y590_RS12565	COG1309	transcriptional regulator
Y590_RS12575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Y590_RS12585	COG0366	Alpha amylase catalytic
Y590_RS12590	COG0366	Alpha amylase catalytic
Y590_RS12595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Y590_RS12600	COG1742	UPF0060 membrane protein
Y590_RS12625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Y590_RS12630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y590_RS12650	COG0564	pseudouridine synthase activity
Y590_RS12655	COG0552	protein localization to endoplasmic reticulum
Y590_RS12675	COG0142	geranyltranstransferase activity
Y590_RS12680	COG0500	methyltransferase
Y590_RS12685	COG1063	alcohol dehydrogenase
Y590_RS12690	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Y590_RS12695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y590_RS12700	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y590_RS12735	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
Y590_RS12740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y590_RS12745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Y590_RS12755	COG0596	Alpha beta hydrolase
Y590_RS12760	COG0469	pyruvate kinase activity
Y590_RS12790	COG3750	Belongs to the UPF0335 family
Y590_RS12795	COG0625	glutathione transferase activity
Y590_RS12810	COG2204	response regulator
Y590_RS12830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Y590_RS12855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Y590_RS12890	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Y590_RS12900	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Y590_RS12905	COG3604	Transcriptional regulator
Y590_RS12915	COG1858	cytochrome C peroxidase
Y590_RS12925	COG5001	Diguanylate cyclase
Y590_RS12955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Y590_RS12970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Y590_RS12975	COG0148	phosphopyruvate hydratase activity
Y590_RS12980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Y590_RS12985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Y590_RS12990	COG0022	dehydrogenase e1 component
Y590_RS12990	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y590_RS13000	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y590_RS13005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y590_RS13050	COG2867	negative regulation of translational initiation
Y590_RS13060	COG2423	ornithine cyclodeaminase activity
Y590_RS13065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Y590_RS13075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Y590_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS13085	COG4638	Rieske (2fe-2S)
Y590_RS13090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Y590_RS13105	COG5265	(ABC) transporter
Y590_RS13115	COG2080	2 iron, 2 sulfur cluster binding
Y590_RS13120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Y590_RS13125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y590_RS13130	COG1058	Belongs to the CinA family
Y590_RS13130	COG1546	Belongs to the CinA family
Y590_RS13135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Y590_RS13135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Y590_RS13140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y590_RS13150	COG2204	response regulator
Y590_RS13155	COG1061	Type III restriction enzyme res subunit
Y590_RS13160	COG5000	phosphorelay sensor kinase activity
Y590_RS13165	COG2204	response regulator
Y590_RS13170	COG1923	regulation of RNA biosynthetic process
Y590_RS13175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Y590_RS13180	COG0659	secondary active sulfate transmembrane transporter activity
Y590_RS13220	COG4957	zinc ion binding
Y590_RS13260	COG0784	Response regulator, receiver
Y590_RS13260	COG4191	Histidine kinase
Y590_RS13285	COG1763	Mo-molybdopterin cofactor biosynthetic process
Y590_RS13300	COG4662	Binding-protein-dependent transport system inner membrane component
Y590_RS13325	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Y590_RS13330	COG2943	transferase activity, transferring hexosyl groups
Y590_RS13345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Y590_RS13350	COG2204	response regulator
Y590_RS13355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Y590_RS13355	COG0037	tRNA processing
Y590_RS13365	COG2884	Cell division ATP-binding protein ftsE
Y590_RS13385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Y590_RS13395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Y590_RS13400	COG0799	negative regulation of ribosome biogenesis
Y590_RS13420	COG1132	(ABC) transporter
Y590_RS13440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Y590_RS13445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Y590_RS13450	COG0322	excinuclease ABC activity
Y590_RS13460	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS13470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y590_RS13475	COG1496	oxidoreductase activity
Y590_RS13485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Y590_RS13490	COG1285	pathogenesis
Y590_RS13495	COG0033	Phosphoglucomutase
Y590_RS13515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y590_RS13515	COG0574	Belongs to the PEP-utilizing enzyme family
Y590_RS13520	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS13525	COG0346	lactoylglutathione lyase activity
Y590_RS13535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y590_RS13535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y590_RS13570	COG0784	Response regulator, receiver
Y590_RS13585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Y590_RS13595	COG1408	metallophosphoesterase
Y590_RS13620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Y590_RS13630	COG1686	Belongs to the peptidase S11 family
Y590_RS13675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Y590_RS13680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y590_RS13690	COG3657	addiction module killer protein
Y590_RS13715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y590_RS13715	COG0519	Catalyzes the synthesis of GMP from XMP
Y590_RS13730	COG0657	acetylesterase activity
Y590_RS13730	COG2755	lipolytic protein G-D-S-L family
Y590_RS13735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y590_RS13735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y590_RS13745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Y590_RS13775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Y590_RS13800	COG1181	Belongs to the D-alanine--D-alanine ligase family
Y590_RS13805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Y590_RS13810	COG0849	cell division
Y590_RS13815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Y590_RS13825	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y590_RS13855	COG0243	molybdopterin cofactor binding
Y590_RS13870	COG0484	heat shock protein binding
Y590_RS13875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Y590_RS13890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Y590_RS13900	COG0295	cytidine deaminase activity
Y590_RS13915	COG1663	tetraacyldisaccharide 4'-kinase activity
Y590_RS13920	COG1519	Transferase
Y590_RS13940	COG1278	Cold shock
Y590_RS13945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Y590_RS13955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Y590_RS13980	COG0739	heme binding
Y590_RS13980	COG1196	nuclear chromosome segregation
Y590_RS13980	COG0741	lytic transglycosylase activity
Y590_RS13985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y590_RS13995	COG3239	Fatty acid desaturase
Y590_RS14000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Y590_RS14015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Y590_RS14020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y590_RS14020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y590_RS14030	COG0123	including yeast histone deacetylase and acetoin utilization protein
Y590_RS14035	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS14045	COG4770	biotin carboxylase activity
Y590_RS14055	COG1254	Belongs to the acylphosphatase family
Y590_RS14075	COG0625	glutathione transferase activity
Y590_RS14080	COG1509	lysine 2,3-aminomutase activity
Y590_RS14085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Y590_RS14100	COG1278	Cold shock
Y590_RS14110	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Y590_RS14120	COG1233	COG1233 Phytoene dehydrogenase and related
Y590_RS14125	COG1562	ergosterol biosynthetic process
Y590_RS14130	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y590_RS14135	COG0830	nickel cation binding
Y590_RS14140	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Y590_RS14145	COG0804	urea catabolic process
Y590_RS14160	COG0832	Belongs to the urease beta subunit family
Y590_RS14160	COG0831	urea catabolic process
Y590_RS14165	COG0829	nickel cation binding
Y590_RS14180	COG2351	hydroxyisourate hydrolase activity
Y590_RS14195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS14200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Y590_RS14225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Y590_RS14235	COG2900	Belongs to the SlyX family
Y590_RS14255	COG1696	Membrane protein involved in D-alanine export
Y590_RS14270	COG1706	bacterial-type flagellum-dependent cell motility
Y590_RS14300	COG4786	Flagellar basal body rod
Y590_RS14305	COG4786	Flagellar basal body rod
Y590_RS14330	COG0386	Belongs to the glutathione peroxidase family
Y590_RS14340	COG2951	lytic endotransglycosylase activity
Y590_RS14345	COG2249	NAD(P)H dehydrogenase (quinone) activity
Y590_RS14355	COG1301	dicarboxylic acid transport
Y590_RS14360	COG4191	Histidine kinase
Y590_RS14365	COG2204	response regulator
Y590_RS14370	COG3706	GGDEF domain
Y590_RS14375	COG5001	Diguanylate cyclase
Y590_RS14410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Y590_RS14420	COG0343	queuine tRNA-ribosyltransferase activity
Y590_RS14460	COG2954	triphosphatase activity
Y590_RS14470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y590_RS14505	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Y590_RS14515	COG1216	Glycosyl transferase, family 2
Y590_RS14515	COG0463	Glycosyl transferase, family 2
Y590_RS14535	COG0436	Aminotransferase
Y590_RS14550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y590_RS14550	COG4651	solute:proton antiporter activity
Y590_RS14575	COG0752	glycyl-tRNA synthetase alpha subunit
Y590_RS14585	COG1309	transcriptional regulator
Y590_RS14605	COG2813	Specifically methylates the guanine in position
Y590_RS14615	COG0142	geranyltranstransferase activity
Y590_RS14620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Y590_RS14655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y590_RS14680	COG0187	DNA topoisomerase II activity
Y590_RS14695	COG1132	(ABC) transporter
Y590_RS14725	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS14730	COG2814	Major facilitator Superfamily
Y590_RS14735	COG2267	carboxylic ester hydrolase activity
Y590_RS14745	COG0625	glutathione transferase activity
Y590_RS14765	COG0590	tRNA wobble adenosine to inosine editing
Y590_RS14785	COG0784	Response regulator, receiver
Y590_RS14785	COG4191	Histidine kinase
Y590_RS14795	COG0538	isocitrate dehydrogenase activity
Y590_RS14810	COG3609	addiction module antidote protein, CC2985 family
Y590_RS14830	COG1063	alcohol dehydrogenase
Y590_RS14835	COG2972	Histidine kinase
Y590_RS14835	COG0840	transmembrane signaling receptor activity
Y590_RS14845	COG2873	o-acetylhomoserine
Y590_RS14855	COG0247	lactate metabolic process
Y590_RS14865	COG0657	acetylesterase activity
Y590_RS14870	COG1201	RNA secondary structure unwinding
Y590_RS14890	COG5487	UPF0391 membrane protein
Y590_RS14895	COG4221	oxidoreductase activity
Y590_RS14905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Y590_RS14910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y590_RS14915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Y590_RS14920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Y590_RS14920	COG0546	phosphoglycolate phosphatase activity
Y590_RS14945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y590_RS14945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y590_RS14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Y590_RS14960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Y590_RS14965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Y590_RS14970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Y590_RS14980	COG0356	it plays a direct role in the translocation of protons across the membrane
Y590_RS14990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Y590_RS15010	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Y590_RS15015	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Y590_RS15025	COG0488	(ABC) transporter
Y590_RS15050	COG0741	lytic transglycosylase activity
Y590_RS15055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y590_RS15060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Y590_RS15070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Y590_RS15085	COG1758	RNA polymerase activity
Y590_RS15090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Y590_RS15095	COG1214	PFAM Peptidase M22, glycoprotease
Y590_RS15120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y590_RS15125	COG1702	phosphate starvation-inducible protein PhoH
Y590_RS15130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Y590_RS15135	COG1253	flavin adenine dinucleotide binding
Y590_RS15140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Y590_RS15150	COG0753	catalase activity
Y590_RS15160	COG3180	Ammonia monooxygenase
Y590_RS15185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Y590_RS15190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Y590_RS15195	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Y590_RS15205	COG0243	molybdopterin cofactor binding
Y590_RS15210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y590_RS15210	COG1648	precorrin-2 dehydrogenase activity
Y590_RS15215	COG1999	signal sequence binding
Y590_RS15280	COG1793	dna ligase
Y590_RS15285	COG0432	Pfam Uncharacterised protein family UPF0047
Y590_RS15290	COG0432	Pfam Uncharacterised protein family UPF0047
Y590_RS15305	COG1024	Enoyl-CoA hydratase
Y590_RS15305	COG1250	3-hydroxyacyl-CoA dehydrogenase
Y590_RS15320	COG0183	Belongs to the thiolase family
Y590_RS15330	COG1960	acyl-CoA dehydrogenase activity
Y590_RS15355	COG0671	phosphoesterase, PA-phosphatase related
Y590_RS15360	COG0673	inositol 2-dehydrogenase activity
Y590_RS15365	COG0612	Peptidase, M16
Y590_RS15380	COG3346	SURF1 family
Y590_RS15395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Y590_RS15410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Y590_RS15420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Y590_RS15430	COG0070	glutamate synthase
Y590_RS15430	COG0069	glutamate synthase activity
Y590_RS15430	COG0067	glutamate synthase
Y590_RS15450	COG4585	Histidine kinase
Y590_RS15465	COG2951	lytic endotransglycosylase activity
Y590_RS15475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y590_RS15505	COG0784	Response regulator, receiver
Y590_RS15505	COG4191	Histidine kinase
Y590_RS15510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y590_RS15515	COG2862	Uncharacterized protein family, UPF0114
Y590_RS15540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y590_RS15545	COG0165	Argininosuccinate lyase
Y590_RS15585	COG0728	peptidoglycan biosynthetic process
Y590_RS15595	COG3541	Predicted nucleotidyltransferase
Y590_RS15600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Y590_RS15610	COG3920	Histidine kinase
Y590_RS15625	COG4783	chaperone-mediated protein folding
Y590_RS15635	COG1396	sequence-specific DNA binding
Y590_RS15640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Y590_RS15645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Y590_RS15650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y590_RS15655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Y590_RS15660	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Y590_RS15670	COG0540	Belongs to the ATCase OTCase family
Y590_RS15700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Y590_RS15705	COG0758	DNA mediated transformation
Y590_RS15740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Y590_RS15765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y590_RS15775	COG1376	ErfK ybiS ycfS ynhG family protein
Y590_RS15790	COG2963	transposase activity
Y590_RS15795	COG3436	PFAM IS66 Orf2 family protein
Y590_RS15800	COG4372	Transposase
Y590_RS15805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y590_RS15815	COG0569	domain protein
Y590_RS15815	COG2985	domain, Protein
Y590_RS15820	COG1554	hydrolase, family 65, central catalytic
Y590_RS15830	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Y590_RS15870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y590_RS15870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y590_RS15935	COG4584	PFAM Integrase catalytic
Y590_RS15940	COG1484	DNA-dependent DNA replication
Y590_RS15975	COG0640	Transcriptional regulator
Y590_RS15980	COG2186	Transcriptional regulator
Y590_RS15990	COG1304	FMN binding
Y590_RS15995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y590_RS16015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Y590_RS16025	COG0411	ABC transporter
Y590_RS16045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y590_RS16045	COG2205	protein histidine kinase activity
Y590_RS16100	COG0316	Belongs to the HesB IscA family
Y590_RS16105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Y590_RS16135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y590_RS16140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y590_RS16145	COG0805	protein transport
Y590_RS16155	COG2814	Major facilitator Superfamily
Y590_RS16165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS16170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS16175	COG1116	anion transmembrane transporter activity
Y590_RS16185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS16190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS16230	COG1309	transcriptional regulator
Y590_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS16240	COG2814	Major facilitator Superfamily
Y590_RS16250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Y590_RS16255	COG1012	belongs to the aldehyde dehydrogenase family
Y590_RS16265	COG0840	transmembrane signaling receptor activity
Y590_RS16265	COG2972	Histidine kinase
Y590_RS16275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Y590_RS16285	COG2259	Doxx family
Y590_RS16290	COG0477	Major facilitator Superfamily
Y590_RS16300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Y590_RS16305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Y590_RS16340	COG1131	(ABC) transporter
Y590_RS16365	COG2030	dehydratase
Y590_RS16390	COG0625	glutathione transferase activity
Y590_RS16425	COG3394	polysaccharide catabolic process
Y590_RS16455	COG3265	gluconokinase activity
Y590_RS16460	COG0561	phosphatase activity
Y590_RS16470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Y590_RS16500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Y590_RS16500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Y590_RS16510	COG2309	aminopeptidase activity
Y590_RS16520	COG0277	FAD linked oxidase domain protein
Y590_RS16555	COG2963	transposase activity
Y590_RS16560	COG1366	Belongs to the anti-sigma-factor antagonist family
Y590_RS16565	COG1366	Belongs to the anti-sigma-factor antagonist family
Y590_RS16570	COG2172	sigma factor antagonist activity
Y590_RS16595	COG0559	Belongs to the binding-protein-dependent transport system permease family
Y590_RS16610	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Y590_RS16615	COG0154	amidase activity
Y590_RS16675	COG0583	DNA-binding transcription factor activity
Y590_RS16680	COG2358	TRAP transporter, solute receptor (TAXI family
Y590_RS16685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS16690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Y590_RS16715	COG2205	protein histidine kinase activity
Y590_RS16720	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Y590_RS16725	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Y590_RS16745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y590_RS16750	COG1414	Transcriptional regulator
Y590_RS16755	COG0028	Belongs to the TPP enzyme family
Y590_RS16760	COG2010	Cytochrome c
Y590_RS16765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Y590_RS16780	COG2855	membrane
Y590_RS16800	COG0583	DNA-binding transcription factor activity
Y590_RS16805	COG2271	Major facilitator Superfamily
Y590_RS16810	COG1012	belongs to the aldehyde dehydrogenase family
Y590_RS16885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS16990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y590_RS16995	COG4566	intracellular signal transduction
Y590_RS17000	COG4191	Histidine kinase
Y590_RS17015	COG2205	protein histidine kinase activity
Y590_RS17015	COG0784	Response regulator, receiver
Y590_RS17015	COG5002	protein histidine kinase activity
Y590_RS17035	COG1063	alcohol dehydrogenase
Y590_RS17075	COG0559	Belongs to the binding-protein-dependent transport system permease family
Y590_RS17090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Y590_RS17100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y590_RS17105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y590_RS17110	COG1522	sequence-specific DNA binding
Y590_RS17210	COG1914	H( )-stimulated, divalent metal cation uptake system
Y590_RS17275	COG1024	Enoyl-CoA hydratase
Y590_RS17285	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS17290	COG0598	Magnesium transport protein CorA
Y590_RS17295	COG3685	Protein conserved in bacteria
Y590_RS17320	COG0784	Response regulator, receiver
Y590_RS17320	COG4191	Histidine kinase
Y590_RS17335	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Y590_RS17365	COG4149	molybdate abc transporter
Y590_RS17375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Y590_RS17385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Y590_RS17390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Y590_RS17420	COG0659	secondary active sulfate transmembrane transporter activity
Y590_RS17470	COG0318	PFAM AMP-dependent synthetase and ligase
Y590_RS17490	COG0436	Aminotransferase
Y590_RS17495	COG1530	ribonuclease E activity
Y590_RS17495	COG1530	ribonuclease E activity
Y590_RS17500	COG0860	N-Acetylmuramoyl-L-alanine amidase
Y590_RS17505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Y590_RS17530	COG2080	2 iron, 2 sulfur cluster binding
Y590_RS17535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Y590_RS17540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y590_RS17550	COG2252	PERMEase
Y590_RS17560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y590_RS17575	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Y590_RS17640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Y590_RS17645	COG0326	Molecular chaperone. Has ATPase activity
Y590_RS17650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y590_RS17665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Y590_RS17670	COG0732	type I restriction modification DNA specificity domain
Y590_RS17680	COG3177	Filamentation induced by cAMP protein fic
Y590_RS17850	COG5001	Diguanylate cyclase
Y590_RS17885	COG4770	biotin carboxylase activity
Y590_RS17890	COG3665	Urea carboxylase-associated protein
Y590_RS17895	COG3665	Urea carboxylase-associated protein
Y590_RS17915	COG1116	anion transmembrane transporter activity
Y590_RS17920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS17930	COG0517	IMP dehydrogenase activity
Y590_RS17930	COG4175	Glycine betaine
Y590_RS17940	COG2113	Glycine betaine
Y590_RS17955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y590_RS17965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y590_RS17965	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y590_RS17975	COG1760	l-serine dehydratase
Y590_RS18000	COG2181	nitrate reductase activity
Y590_RS18000	COG0247	lactate metabolic process
Y590_RS18005	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y590_RS18005	COG1902	pentaerythritol trinitrate reductase activity
Y590_RS18010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y590_RS18010	COG1017	nitric oxide dioxygenase activity
Y590_RS18015	COG4638	Rieske (2fe-2S)
Y590_RS18035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y590_RS18040	COG4172	Belongs to the ABC transporter superfamily
Y590_RS18050	COG0601	transmembrane transport
Y590_RS18090	COG1082	Xylose isomerase domain protein TIM barrel
Y590_RS18100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y590_RS18150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Y590_RS18170	COG2030	dehydratase
Y590_RS18200	COG2963	transposase activity
Y590_RS18215	COG0583	DNA-binding transcription factor activity
Y590_RS18255	COG0038	chloride channel
Y590_RS18270	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS18280	COG1294	oxidase, subunit
Y590_RS18285	COG1271	oxidase subunit
Y590_RS18305	COG0596	Alpha beta hydrolase
Y590_RS18310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Y590_RS18315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y590_RS18320	COG1120	ATPase activity
Y590_RS18325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Y590_RS18355	COG0667	Aldo Keto reductase
Y590_RS18365	COG1335	isochorismatase
Y590_RS18375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y590_RS18390	COG0656	L-ascorbic acid biosynthetic process
Y590_RS18395	COG0742	ribosomal rna small subunit methyltransferase
Y590_RS18405	COG5001	Diguanylate cyclase
Y590_RS18410	COG0596	Alpha beta hydrolase
Y590_RS18420	COG0590	tRNA wobble adenosine to inosine editing
Y590_RS18425	COG0151	Belongs to the GarS family
Y590_RS18450	COG1570	exodeoxyribonuclease VII activity
Y590_RS18470	COG2197	response regulator
Y590_RS18475	COG3851	Histidine kinase
Y590_RS18485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y590_RS18490	COG0604	alcohol dehydrogenase
Y590_RS18545	COG3485	protocatechuate 3,4-dioxygenase
Y590_RS18550	COG3485	protocatechuate 3,4-dioxygenase
Y590_RS18555	COG3246	L-lysine catabolic process to acetate
Y590_RS18560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y590_RS18565	COG0596	Alpha beta hydrolase
Y590_RS18595	COG1024	Enoyl-CoA hydratase
Y590_RS18605	COG2814	Major facilitator Superfamily
Y590_RS18630	COG0463	Glycosyl transferase, family 2
Y590_RS18630	COG1216	Glycosyl transferase, family 2
Y590_RS18640	COG0438	transferase activity, transferring glycosyl groups
Y590_RS18645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS18655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS18670	COG1086	Polysaccharide biosynthesis protein
Y590_RS18680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Y590_RS18690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y590_RS18695	COG1595	DNA-templated transcription, initiation
Y590_RS18780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y590_RS18800	COG1335	isochorismatase
Y590_RS18805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y590_RS18820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y590_RS18835	COG3956	TIGRFAM MazG family protein
Y590_RS18855	COG2301	Belongs to the HpcH HpaI aldolase family
Y590_RS18865	COG3706	GGDEF domain
Y590_RS18900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Y590_RS18905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Y590_RS18910	COG2226	methyltransferase
Y590_RS18920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Y590_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS18930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Y590_RS18945	COG1999	signal sequence binding
Y590_RS18955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y590_RS18970	COG0359	binds to the 23S rRNA
Y590_RS18980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Y590_RS18985	COG0360	Binds together with S18 to 16S ribosomal RNA
Y590_RS19005	COG1278	Cold shock
Y590_RS19015	COG0242	peptide deformylase activity
Y590_RS19045	COG2610	gluconate transmembrane transporter activity
Y590_RS19050	COG1301	dicarboxylic acid transport
Y590_RS19060	COG1027	Aspartate ammonia-lyase
Y590_RS19080	COG0765	amino acid transport
Y590_RS19085	COG0765	amino acid transport
Y590_RS19090	COG1126	abc transporter atp-binding protein
Y590_RS19100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Y590_RS19145	COG2945	thiolester hydrolase activity
Y590_RS19150	COG1104	cysteine desulfurase activity
Y590_RS19155	COG0719	Fe-S assembly protein
Y590_RS19160	COG0396	ATPase activity
Y590_RS19165	COG0719	Fe-S assembly protein
Y590_RS19170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Y590_RS19185	COG0316	Belongs to the HesB IscA family
Y590_RS19190	COG3706	GGDEF domain
Y590_RS19190	COG5001	Diguanylate cyclase
Y590_RS19190	COG4251	negative regulation of phosphorylation
Y590_RS19190	COG2203	Gaf domain
Y590_RS19195	COG0513	Belongs to the DEAD box helicase family
Y590_RS19205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y590_RS19245	COG4181	ATPase activity
Y590_RS19270	COG0250	Participates in transcription elongation, termination and antitermination
Y590_RS19275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Y590_RS19280	COG0081	regulation of translation
Y590_RS19285	COG2124	cytochrome p450
Y590_RS19290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y590_RS19315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Y590_RS19345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Y590_RS19350	COG0222	ribosome binding
Y590_RS19355	COG0085	RNA polymerase activity
Y590_RS19360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Y590_RS19375	COG0251	oxidation-reduction process
Y590_RS19380	COG2261	transglycosylase associated protein
Y590_RS19400	COG1185	polyribonucleotide nucleotidyltransferase activity
Y590_RS19405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Y590_RS19415	COG0531	amino acid
Y590_RS19430	COG5001	Diguanylate cyclase
Y590_RS19440	COG1674	ftsk spoiiie
Y590_RS19450	COG0784	Response regulator, receiver
Y590_RS19460	COG2807	transmembrane transport
Y590_RS19490	COG0730	response to heat
Y590_RS19495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Y590_RS19500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Y590_RS19510	COG1959	2 iron, 2 sulfur cluster binding
Y590_RS19515	COG3634	alkyl hydroperoxide reductase activity
Y590_RS19530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Y590_RS19540	COG0784	Response regulator, receiver
Y590_RS19540	COG4191	Histidine kinase
Y590_RS19550	COG3753	Protein conserved in bacteria
Y590_RS19560	COG0556	nucleotide-excision repair
Y590_RS19570	COG0583	DNA-binding transcription factor activity
Y590_RS19580	COG2514	catechol 2,3-dioxygenase activity
Y590_RS19595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Y590_RS19615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Y590_RS19640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y590_RS19650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Y590_RS19655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Y590_RS19665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Y590_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS19690	COG4251	negative regulation of phosphorylation
Y590_RS19720	COG2204	response regulator
Y590_RS19725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y590_RS19735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y590_RS19740	COG1766	The M ring may be actively involved in energy transduction
Y590_RS19760	COG0482	sulfurtransferase activity
Y590_RS19770	COG0398	Pfam SNARE associated Golgi protein
Y590_RS19795	COG1960	acyl-CoA dehydrogenase activity
Y590_RS19800	COG0009	L-threonylcarbamoyladenylate synthase
Y590_RS19805	COG4191	Histidine kinase
Y590_RS19805	COG0784	Response regulator, receiver
Y590_RS19815	COG4251	negative regulation of phosphorylation
Y590_RS19820	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Y590_RS19825	COG0784	Response regulator, receiver
Y590_RS19825	COG4191	Histidine kinase
Y590_RS19875	COG4774	siderophore transport
Y590_RS19895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y590_RS19915	COG0489	protein tyrosine kinase activity
Y590_RS19915	COG3206	protein involved in exopolysaccharide biosynthesis
Y590_RS19920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Y590_RS19925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS19935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS19940	COG1596	polysaccharide export
Y590_RS19945	COG0662	Cupin 2, conserved barrel domain protein
Y590_RS19945	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Y590_RS20000	COG0714	Associated with various cellular activities
Y590_RS20010	COG2010	Cytochrome c
Y590_RS20015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y590_RS20020	COG4993	Dehydrogenase
Y590_RS20065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Y590_RS20070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y590_RS20095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Y590_RS20110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y590_RS20115	COG1278	Cold shock
Y590_RS20145	COG4191	Histidine kinase
Y590_RS20145	COG0784	Response regulator, receiver
Y590_RS20155	COG0318	PFAM AMP-dependent synthetase and ligase
Y590_RS20165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Y590_RS20170	COG0463	Glycosyl transferase, family 2
Y590_RS20185	COG2072	flavoprotein involved in K transport
Y590_RS20200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Y590_RS20210	COG3920	Histidine kinase
Y590_RS20230	COG0084	hydrolase, TatD family'
Y590_RS20255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y590_RS20260	COG1177	transmembrane transport
Y590_RS20265	COG1176	ABC-type spermidine putrescine transport system, permease component I
Y590_RS20270	COG3842	ATPase activity
Y590_RS20295	COG2271	Major facilitator Superfamily
Y590_RS20300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Y590_RS20310	COG3622	Belongs to the hyi family
Y590_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS20330	COG0247	lactate metabolic process
Y590_RS20360	COG0321	lipoyl(octanoyl) transferase activity
Y590_RS20380	COG0745	RESPONSE REGULATOR receiver
Y590_RS20395	COG0436	Aminotransferase
Y590_RS20400	COG0697	spore germination
Y590_RS20420	COG1620	l-lactate permease
Y590_RS20425	COG3546	catalase activity
Y590_RS20435	COG3737	Protein of unknown function (DUF498/DUF598)
Y590_RS20445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y590_RS20450	COG1862	Preprotein translocase
Y590_RS20465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Y590_RS20470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Y590_RS20475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Y590_RS20490	COG1846	Transcriptional regulator
Y590_RS20500	COG1024	Enoyl-CoA hydratase
Y590_RS20505	COG0113	porphobilinogen synthase activity
Y590_RS20525	COG0110	maltose O-acetyltransferase activity
Y590_RS20530	COG2321	neutral zinc metallopeptidase
Y590_RS20535	COG1573	uracil-dna glycosylase
Y590_RS20545	COG3191	aminopeptidase activity
Y590_RS20560	COG0626	cystathionine gamma-synthase activity
Y590_RS20565	COG0655	NAD(P)H dehydrogenase (quinone) activity
Y590_RS20570	COG1595	DNA-templated transcription, initiation
Y590_RS20575	COG0259	pyridoxamine-phosphate oxidase activity
Y590_RS20580	COG0784	Response regulator, receiver
Y590_RS20580	COG4191	Histidine kinase
Y590_RS20590	COG0438	transferase activity, transferring glycosyl groups
Y590_RS20590	COG1216	Glycosyl transferase, family 2
Y590_RS20600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Y590_RS20605	COG0071	Belongs to the small heat shock protein (HSP20) family
Y590_RS20615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Y590_RS20625	COG0488	(ABC) transporter
Y590_RS20655	COG4166	transmembrane transport
Y590_RS20660	COG0601	transmembrane transport
Y590_RS20665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y590_RS20675	COG2271	Major facilitator Superfamily
Y590_RS20695	COG0655	NAD(P)H dehydrogenase (quinone) activity
Y590_RS20705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Y590_RS20715	COG1643	Atp-dependent helicase
Y590_RS20735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Y590_RS20745	COG2326	polyphosphate kinase activity
Y590_RS20760	COG2258	MOSC domain
Y590_RS20765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Y590_RS20770	COG0484	heat shock protein binding
Y590_RS20780	COG0259	pyridoxamine-phosphate oxidase activity
Y590_RS20790	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS20820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Y590_RS20830	COG2818	Glycosylase
Y590_RS20835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Y590_RS20845	COG1722	exodeoxyribonuclease VII activity
Y590_RS20850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Y590_RS20855	COG2032	superoxide dismutase activity
Y590_RS20860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Y590_RS20865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y590_RS20890	COG1473	amidohydrolase
Y590_RS20895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y590_RS20895	COG2169	Transcriptional regulator
Y590_RS20905	COG0537	adenosine 5'-monophosphoramidase activity
Y590_RS20920	COG3387	PFAM Glycoside hydrolase 15-related
Y590_RS20930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Y590_RS20935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y590_RS20940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Y590_RS20950	COG0252	asparaginase activity
Y590_RS20960	COG0398	Pfam SNARE associated Golgi protein
Y590_RS20975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Y590_RS20980	COG1845	cytochrome c oxidase, subunit III
Y590_RS20985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Y590_RS20990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Y590_RS20995	COG0477	Major facilitator Superfamily
Y590_RS21000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y590_RS21020	COG2197	response regulator
Y590_RS21030	COG2197	response regulator
Y590_RS21035	COG2197	response regulator
Y590_RS21085	COG5001	Diguanylate cyclase
Y590_RS21100	COG3920	Histidine kinase
Y590_RS21100	COG2202	Pas domain
Y590_RS21120	COG4974	Belongs to the 'phage' integrase family
Y590_RS21125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Y590_RS21140	COG0488	(ABC) transporter
Y590_RS21145	COG1484	DNA-dependent DNA replication
Y590_RS21150	COG4584	PFAM Integrase catalytic
Y590_RS21160	COG2205	protein histidine kinase activity
Y590_RS21200	COG2801	Transposase and inactivated derivatives
Y590_RS21220	COG4372	Transposase
Y590_RS21225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y590_RS21250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y590_RS21275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS21280	COG1116	anion transmembrane transporter activity
Y590_RS21295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Y590_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS21380	COG0542	response to heat
Y590_RS21385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Y590_RS21435	COG2909	trisaccharide binding
Y590_RS21440	COG0318	PFAM AMP-dependent synthetase and ligase
Y590_RS21450	COG1024	Enoyl-CoA hydratase
Y590_RS21460	COG0183	Belongs to the thiolase family
Y590_RS21485	COG2070	2-Nitropropane dioxygenase
Y590_RS21490	COG3047	cAMP biosynthetic process
Y590_RS21495	COG1960	acyl-CoA dehydrogenase activity
Y590_RS21580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Y590_RS21620	COG2963	transposase activity
Y590_RS21635	COG2801	Transposase and inactivated derivatives
Y590_RS21650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y590_RS21695	COG1877	trehalose-phosphatase activity
Y590_RS21725	COG3383	formate dehydrogenase (NAD+) activity
Y590_RS21735	COG0583	DNA-binding transcription factor activity
Y590_RS21745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y590_RS21760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Y590_RS21765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Y590_RS21770	COG0433	COG0433 Predicted ATPase
Y590_RS21820	COG1597	lipid kinase activity
Y590_RS21830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Y590_RS21840	COG5002	protein histidine kinase activity
Y590_RS21840	COG2205	protein histidine kinase activity
Y590_RS21840	COG0784	Response regulator, receiver
Y590_RS21850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Y590_RS21855	COG3178	'Phosphotransferase
Y590_RS21860	COG2205	protein histidine kinase activity
Y590_RS21865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Y590_RS21870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Y590_RS21880	COG1024	Enoyl-CoA hydratase
Y590_RS21890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y590_RS21900	COG1074	ATP-dependent DNA helicase activity
Y590_RS21905	COG2133	pyrroloquinoline quinone binding
Y590_RS21915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y590_RS21920	COG0285	dihydrofolate synthase activity
Y590_RS21925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Y590_RS21935	COG2816	NAD+ diphosphatase activity
Y590_RS21955	COG0513	Belongs to the DEAD box helicase family
Y590_RS21975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Y590_RS21975	COG0352	thiamine-phosphate diphosphorylase activity
Y590_RS21975	COG0351	phosphomethylpyrimidine kinase
Y590_RS21980	COG0531	amino acid
Y590_RS21990	COG3034	peptidoglycan biosynthetic process
Y590_RS21995	COG4988	ABC transporter
Y590_RS22010	COG0121	glutamine amidotransferase
Y590_RS22020	COG4957	zinc ion binding
Y590_RS22035	COG0633	Ferredoxin
Y590_RS22050	COG1396	sequence-specific DNA binding
Y590_RS22055	COG0351	phosphomethylpyrimidine kinase
Y590_RS22060	COG0352	thiamine-phosphate diphosphorylase activity
Y590_RS22080	COG4957	zinc ion binding
Y590_RS22100	COG2264	protein methyltransferase activity
Y590_RS22105	COG0006	proline dipeptidase activity
Y590_RS22105	COG0006	proline dipeptidase activity
Y590_RS22110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Y590_RS22145	COG0625	glutathione transferase activity
Y590_RS22160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y590_RS22165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y590_RS22170	COG1116	anion transmembrane transporter activity
Y590_RS22175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y590_RS22180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS22185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Y590_RS22200	COG3387	PFAM Glycoside hydrolase 15-related
Y590_RS22210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y590_RS22215	COG0586	Pfam SNARE associated Golgi protein
Y590_RS22250	COG1054	Belongs to the UPF0176 family
Y590_RS22255	COG0438	transferase activity, transferring glycosyl groups
Y590_RS22265	COG3916	Acyl-homoserine-lactone synthase
Y590_RS22270	COG2197	response regulator
Y590_RS22480	COG0673	inositol 2-dehydrogenase activity
Y590_RS22490	COG0583	DNA-binding transcription factor activity
Y590_RS22495	COG1063	alcohol dehydrogenase
Y590_RS22500	COG3920	Histidine kinase
Y590_RS22500	COG2202	Pas domain
Y590_RS22510	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS22525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y590_RS22530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Y590_RS22545	COG0628	permease
Y590_RS22570	COG0071	Belongs to the small heat shock protein (HSP20) family
Y590_RS22585	COG0483	inositol monophosphate 1-phosphatase activity
Y590_RS22590	COG0628	permease
Y590_RS22595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Y590_RS22605	COG2304	oxidoreductase activity
Y590_RS22620	COG3871	stress protein (general stress protein 26)
Y590_RS22635	COG0746	molybdenum cofactor guanylyltransferase activity
Y590_RS22640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Y590_RS22645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y590_RS22650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Y590_RS22670	COG2205	protein histidine kinase activity
Y590_RS22670	COG0784	Response regulator, receiver
Y590_RS22685	COG0587	DNA-directed DNA polymerase activity
Y590_RS22700	COG3479	Phenolic acid decarboxylase
Y590_RS22750	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS22765	COG0657	acetylesterase activity
Y590_RS22770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Y590_RS22780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Y590_RS22810	COG2873	o-acetylhomoserine
Y590_RS22820	COG0318	PFAM AMP-dependent synthetase and ligase
Y590_RS22840	COG1032	radical SAM domain protein
Y590_RS22845	COG1320	monovalent cation:proton antiporter activity
Y590_RS22850	COG2212	antiporter activity
Y590_RS22855	COG1863	multisubunit Na H antiporter MnhE subunit
Y590_RS22860	COG0651	ATP synthesis coupled electron transport
Y590_RS22865	COG1006	Multisubunit Na H antiporter MnhC subunit
Y590_RS22870	COG2111	Na H antiporter
Y590_RS22870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y590_RS22885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Y590_RS22895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y590_RS22905	COG0438	transferase activity, transferring glycosyl groups
Y590_RS22935	COG0667	Aldo Keto reductase
Y590_RS22940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y590_RS22960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Y590_RS22970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Y590_RS22975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Y590_RS22990	COG0275	rRNA processing
Y590_RS23015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y590_RS23030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Y590_RS23035	COG1024	Enoyl-CoA hydratase
Y590_RS23055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Y590_RS23080	COG0754	glutathionylspermidine amidase activity
Y590_RS23090	COG3766	membrane
Y590_RS23120	COG0149	triose-phosphate isomerase activity
Y590_RS23130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Y590_RS23145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Y590_RS23150	COG0134	indole-3-glycerol-phosphate synthase activity
Y590_RS23155	COG0315	cyclic pyranopterin monophosphate synthase activity
Y590_RS23160	COG0303	'Molybdopterin
Y590_RS23165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y590_RS23170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y590_RS23180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y590_RS23185	COG1671	Belongs to the UPF0178 family
Y590_RS23190	COG0372	Belongs to the citrate synthase family
Y590_RS23195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y590_RS23205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Y590_RS23215	COG0477	Major facilitator Superfamily
Y590_RS23220	COG3246	L-lysine catabolic process to acetate
Y590_RS23225	COG0473	3-isopropylmalate dehydrogenase activity
Y590_RS23255	COG0525	valine-tRNA ligase activity
Y590_RS23270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Y590_RS23320	COG0573	inorganic phosphate transmembrane transporter activity
Y590_RS23325	COG0581	inorganic phosphate transmembrane transporter activity
Y590_RS23330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Y590_RS23335	COG0704	Plays a role in the regulation of phosphate uptake
Y590_RS23340	COG0745	RESPONSE REGULATOR receiver
Y590_RS23355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Y590_RS23365	COG1492	cobalamin metabolic process
Y590_RS23370	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Y590_RS23380	COG2814	Major facilitator Superfamily
Y590_RS23395	COG3237	CsbD-like
Y590_RS23400	COG1028	Short-chain dehydrogenase reductase Sdr
Y590_RS23405	COG0825	malonyl-CoA metabolic process
Y590_RS23415	COG3034	peptidoglycan biosynthetic process
Y590_RS23420	COG0335	large ribosomal subunit rRNA binding
Y590_RS23430	COG2951	lytic endotransglycosylase activity
Y590_RS23435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Y590_RS23455	COG1183	phosphatidylcholine synthase activity
Y590_RS23460	COG0688	phosphatidylethanolamine metabolic process
Y590_RS23465	COG5002	protein histidine kinase activity
Y590_RS23465	COG3447	MASE1 domain protein
Y590_RS23465	COG5001	Diguanylate cyclase
Y590_RS23470	COG5265	(ABC) transporter
Y590_RS23490	COG0215	cysteine-tRNA ligase activity
Y590_RS23500	COG3045	CreA protein
Y590_RS23515	COG2814	Major facilitator Superfamily
Y590_RS23525	COG2226	methyltransferase
Y590_RS23535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y590_RS23540	COG1566	PFAM secretion protein HlyD family protein
Y590_RS23565	COG0625	glutathione transferase activity
Y590_RS23570	COG0823	Involved in the tonB-independent uptake of proteins
Y590_RS23580	COG0848	biopolymer transport protein
Y590_RS23585	COG0811	peptide transport
Y590_RS23595	COG0824	Thioesterase
Y590_RS23605	COG1408	metallophosphoesterase
Y590_RS23610	COG2255	four-way junction helicase activity
Y590_RS23620	COG0783	Belongs to the Dps family
Y590_RS23625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y590_RS23625	COG1042	CoA-binding domain protein
Y590_RS23625	COG0045	succinate-CoA ligase (ADP-forming) activity
Y590_RS23630	COG0235	Class ii aldolase
Y590_RS23635	COG4957	zinc ion binding
Y590_RS23655	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Y590_RS23665	COG1192	Involved in chromosome partitioning
Y590_RS23680	COG0459	protein refolding
Y590_RS23685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Y590_RS23690	COG0598	Magnesium transport protein CorA
Y590_RS23695	COG2095	MarC family integral membrane protein
Y590_RS23705	COG0277	FAD linked oxidase domain protein
Y590_RS23710	COG0306	phosphate transporter
Y590_RS23750	COG3739	integral membrane protein
Y590_RS23760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y590_RS23765	COG0484	heat shock protein binding
Y590_RS23770	COG1686	Belongs to the peptidase S11 family
Y590_RS23775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Y590_RS23790	COG0156	8-amino-7-oxononanoate synthase activity
Y590_RS23800	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Y590_RS23840	COG1429	ligase activity, forming nitrogen-metal bonds
Y590_RS23845	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y590_RS23850	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y590_RS23870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Y590_RS23875	COG2211	Major facilitator Superfamily
Y590_RS23880	COG0644	oxidoreductase
Y590_RS23895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y590_RS23895	COG2010	Cytochrome c
Y590_RS23900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Y590_RS23905	COG0363	glucosamine-6-phosphate deaminase activity
Y590_RS23915	COG1132	(ABC) transporter
Y590_RS23920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Y590_RS23935	COG3264	Mechanosensitive ion channel
Y590_RS23935	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Y590_RS23965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y590_RS23975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y590_RS23980	COG0037	tRNA processing
Y590_RS23990	COG2885	chlorophyll binding
Y590_RS24000	COG0745	RESPONSE REGULATOR receiver
Y590_RS24015	COG0181	hydroxymethylbilane synthase activity
Y590_RS24040	COG0405	Gamma-glutamyltransferase
Y590_RS24050	COG1129	ABC transporter
Y590_RS24105	COG3685	Protein conserved in bacteria
Y590_RS24115	COG0028	Belongs to the TPP enzyme family
Y590_RS24135	COG0367	asparagine synthase
Y590_RS24155	COG3920	Histidine kinase
Y590_RS24160	COG3437	response regulator, receiver
Y590_RS24175	COG4566	intracellular signal transduction
Y590_RS24200	COG0268	Binds directly to 16S ribosomal RNA
Y590_RS24205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y590_RS24460	COG0616	signal peptide processing
Y590_RS24480	COG0539	negative regulation of cytoplasmic translation
Y590_RS24675	COG0488	(ABC) transporter
Y590_RS24980	COG0459	protein refolding