locus-tag	class	description
A3862_RS00025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A3862_RS00035	COG0583	DNA-binding transcription factor activity
A3862_RS00055	COG2855	membrane
A3862_RS00075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3862_RS00080	COG1024	Enoyl-CoA hydratase
A3862_RS00085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A3862_RS00095	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS00100	COG0477	Major facilitator Superfamily
A3862_RS00105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS00110	COG0477	Major facilitator Superfamily
A3862_RS00115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3862_RS00120	COG0583	DNA-binding transcription factor activity
A3862_RS00145	COG1278	Cold shock
A3862_RS00165	COG2204	response regulator
A3862_RS00170	COG4191	Histidine kinase
A3862_RS00175	COG1301	dicarboxylic acid transport
A3862_RS00180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A3862_RS00210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS00215	COG0765	amino acid transport
A3862_RS00220	COG1126	abc transporter atp-binding protein
A3862_RS00225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3862_RS00240	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A3862_RS00250	COG0579	oxidoreductase
A3862_RS00280	COG0688	phosphatidylethanolamine metabolic process
A3862_RS00285	COG0419	ATPase involved in DNA repair
A3862_RS00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3862_RS00490	COG0431	NADPH-dependent FMN reductase
A3862_RS00555	COG1595	DNA-templated transcription, initiation
A3862_RS00580	COG2132	Multicopper oxidase
A3862_RS00630	COG0789	Transcriptional regulator
A3862_RS00655	COG2205	protein histidine kinase activity
A3862_RS00720	COG0642	Histidine kinase
A3862_RS00765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3862_RS00780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A3862_RS00835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3862_RS00880	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3862_RS00885	COG4191	Histidine kinase
A3862_RS00885	COG0784	Response regulator, receiver
A3862_RS00890	COG4191	Histidine kinase
A3862_RS00895	COG0745	RESPONSE REGULATOR receiver
A3862_RS00915	COG5002	protein histidine kinase activity
A3862_RS00915	COG0784	Response regulator, receiver
A3862_RS00920	COG0784	Response regulator, receiver
A3862_RS00920	COG4191	Histidine kinase
A3862_RS00935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A3862_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS00950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS00955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS00965	COG1464	Belongs to the NlpA lipoprotein family
A3862_RS00975	COG0328	RNA-DNA hybrid ribonuclease activity
A3862_RS01005	COG1131	(ABC) transporter
A3862_RS01030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A3862_RS01045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A3862_RS01065	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS01105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3862_RS01110	COG0778	Nitroreductase
A3862_RS01120	COG0697	spore germination
A3862_RS01135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3862_RS01150	COG3048	D-serine ammonia-lyase activity
A3862_RS01165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3862_RS01175	COG0745	RESPONSE REGULATOR receiver
A3862_RS01180	COG5002	protein histidine kinase activity
A3862_RS01210	COG5001	Diguanylate cyclase
A3862_RS01210	COG3300	MHYT domain
A3862_RS01225	COG0784	Response regulator, receiver
A3862_RS01245	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A3862_RS01255	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A3862_RS01260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A3862_RS01265	COG2205	protein histidine kinase activity
A3862_RS01280	COG2252	PERMEase
A3862_RS01285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS01285	COG2080	2 iron, 2 sulfur cluster binding
A3862_RS01320	COG1271	oxidase subunit
A3862_RS01325	COG1294	oxidase, subunit
A3862_RS01355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3862_RS01365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3862_RS01370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3862_RS01380	COG0489	protein tyrosine kinase activity
A3862_RS01380	COG3206	protein involved in exopolysaccharide biosynthesis
A3862_RS01385	COG0438	transferase activity, transferring glycosyl groups
A3862_RS01390	COG0438	transferase activity, transferring glycosyl groups
A3862_RS01405	COG2244	polysaccharide biosynthetic process
A3862_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
A3862_RS01445	COG3052	prosthetic group binding
A3862_RS01465	COG2186	Transcriptional regulator
A3862_RS01490	COG0126	phosphoglycerate kinase activity
A3862_RS01505	COG0352	thiamine-phosphate diphosphorylase activity
A3862_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
A3862_RS01560	COG1278	Cold shock
A3862_RS01570	COG0248	Ppx GppA phosphatase
A3862_RS01575	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A3862_RS01590	COG2890	protein-(glutamine-N5) methyltransferase activity
A3862_RS01595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A3862_RS01600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3862_RS01605	COG0527	aspartate kinase activity
A3862_RS01610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A3862_RS01625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A3862_RS01635	COG0596	Alpha beta hydrolase
A3862_RS01640	COG0469	pyruvate kinase activity
A3862_RS01665	COG3750	Belongs to the UPF0335 family
A3862_RS01675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A3862_RS01710	COG0588	phosphoglycerate mutase activity
A3862_RS01715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A3862_RS01730	COG0632	four-way junction helicase activity
A3862_RS01745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A3862_RS01750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A3862_RS01760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3862_RS01765	COG2140	Oxalate decarboxylase
A3862_RS01770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A3862_RS01775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A3862_RS01785	COG0799	negative regulation of ribosome biogenesis
A3862_RS01790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A3862_RS01800	COG0793	Belongs to the peptidase S41A family
A3862_RS01810	COG0494	nUDIX hydrolase
A3862_RS01850	COG2755	lipolytic protein G-D-S-L family
A3862_RS01850	COG0657	acetylesterase activity
A3862_RS01860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3862_RS01875	COG0477	Major facilitator Superfamily
A3862_RS01880	COG2259	Doxx family
A3862_RS01885	COG2814	Major facilitator Superfamily
A3862_RS01900	COG2902	Dehydrogenase
A3862_RS01905	COG2814	Major facilitator Superfamily
A3862_RS01910	COG4957	zinc ion binding
A3862_RS01920	COG0590	tRNA wobble adenosine to inosine editing
A3862_RS01925	COG3237	CsbD-like
A3862_RS01930	COG5487	UPF0391 membrane protein
A3862_RS01935	COG1187	pseudouridine synthase activity
A3862_RS01940	COG0742	ribosomal rna small subunit methyltransferase
A3862_RS01950	COG1396	sequence-specific DNA binding
A3862_RS01965	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS01990	COG4214	carbohydrate transport
A3862_RS01995	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3862_RS02015	COG3734	2-keto-3-deoxy-galactonokinase
A3862_RS02020	COG0800	Aldolase
A3862_RS02035	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3862_RS02040	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A3862_RS02085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3862_RS02095	COG2951	lytic endotransglycosylase activity
A3862_RS02110	COG0070	glutamate synthase
A3862_RS02110	COG0069	glutamate synthase activity
A3862_RS02110	COG0067	glutamate synthase
A3862_RS02120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A3862_RS02130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3862_RS02135	COG0109	protoheme IX farnesyltransferase activity
A3862_RS02140	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A3862_RS02155	COG3346	SURF1 family
A3862_RS02185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A3862_RS02190	COG0343	queuine tRNA-ribosyltransferase activity
A3862_RS02225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3862_RS02240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS02250	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS02250	COG1024	Enoyl-CoA hydratase
A3862_RS02255	COG2199	diguanylate cyclase activity
A3862_RS02255	COG2200	EAL domain
A3862_RS02255	COG2203	Gaf domain
A3862_RS02265	COG0183	Belongs to the thiolase family
A3862_RS02270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A3862_RS02275	COG0268	Binds directly to 16S ribosomal RNA
A3862_RS02280	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3862_RS02285	COG4133	protoheme IX ABC transporter activity
A3862_RS02300	COG0538	isocitrate dehydrogenase activity
A3862_RS02310	COG3916	Acyl-homoserine-lactone synthase
A3862_RS02315	COG2197	response regulator
A3862_RS02335	COG1960	acyl-CoA dehydrogenase activity
A3862_RS02470	COG3237	CsbD-like
A3862_RS02520	COG0564	pseudouridine synthase activity
A3862_RS02525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3862_RS02535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3862_RS02550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3862_RS02570	COG0113	porphobilinogen synthase activity
A3862_RS02580	COG1846	Transcriptional regulator
A3862_RS02585	COG3932	Exopolysaccharide synthesis, ExoD
A3862_RS02595	COG3046	protein related to deoxyribodipyrimidine photolyase
A3862_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS02605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3862_RS02645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3862_RS02650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A3862_RS02670	COG1522	sequence-specific DNA binding
A3862_RS02680	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3862_RS02685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3862_RS02690	COG3161	chorismate lyase activity
A3862_RS02705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3862_RS02730	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS02750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3862_RS02760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3862_RS02775	COG0138	bifunctional purine biosynthesis protein purh
A3862_RS02785	COG0803	Belongs to the bacterial solute-binding protein 9 family
A3862_RS02795	COG1132	(ABC) transporter
A3862_RS02800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3862_RS02825	COG2239	Acts as a magnesium transporter
A3862_RS02835	COG4191	Histidine kinase
A3862_RS02850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3862_RS02855	COG0392	lysyltransferase activity
A3862_RS02880	COG0215	cysteine-tRNA ligase activity
A3862_RS02890	COG3045	CreA protein
A3862_RS02905	COG2226	methyltransferase
A3862_RS02910	COG1253	flavin adenine dinucleotide binding
A3862_RS02915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3862_RS02920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3862_RS02960	COG1696	Membrane protein involved in D-alanine export
A3862_RS02965	COG0443	Heat shock 70 kDa protein
A3862_RS02980	COG1706	bacterial-type flagellum-dependent cell motility
A3862_RS02985	COG3951	Flagellar rod assembly protein muramidase FlgJ
A3862_RS03015	COG1749	Flagellar hook protein flgE
A3862_RS03025	COG0745	RESPONSE REGULATOR receiver
A3862_RS03030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A3862_RS03050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A3862_RS03055	COG0784	Response regulator, receiver
A3862_RS03055	COG4191	Histidine kinase
A3862_RS03060	COG0121	glutamine amidotransferase
A3862_RS03080	COG3706	GGDEF domain
A3862_RS03090	COG0406	alpha-ribazole phosphatase activity
A3862_RS03095	COG2326	polyphosphate kinase activity
A3862_RS03105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3862_RS03120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3862_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3862_RS03130	COG1120	ATPase activity
A3862_RS03165	COG5002	protein histidine kinase activity
A3862_RS03165	COG2198	Histidine kinase
A3862_RS03165	COG0784	Response regulator, receiver
A3862_RS03185	COG0411	ABC transporter
A3862_RS03195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3862_RS03210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3862_RS03225	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS03235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3862_RS03245	COG0477	Major facilitator Superfamily
A3862_RS03335	COG1045	serine acetyltransferase
A3862_RS03350	COG1216	Glycosyl transferase, family 2
A3862_RS03365	COG2271	Major facilitator Superfamily
A3862_RS03375	COG1137	ATPase activity
A3862_RS03390	COG0326	Molecular chaperone. Has ATPase activity
A3862_RS03395	COG3158	transport of potassium into the cell
A3862_RS03405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A3862_RS03415	COG0656	L-ascorbic acid biosynthetic process
A3862_RS03420	COG2080	2 iron, 2 sulfur cluster binding
A3862_RS03425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3862_RS03430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS03435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3862_RS03440	COG2239	Acts as a magnesium transporter
A3862_RS03460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A3862_RS03480	COG2072	flavoprotein involved in K transport
A3862_RS03485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3862_RS03505	COG0542	response to heat
A3862_RS03525	COG0494	nUDIX hydrolase
A3862_RS03530	COG0625	glutathione transferase activity
A3862_RS03535	COG3386	PFAM SMP-30 Gluconolaconase
A3862_RS03550	COG0590	tRNA wobble adenosine to inosine editing
A3862_RS03560	COG5001	Diguanylate cyclase
A3862_RS03560	COG3300	MHYT domain
A3862_RS03580	COG0525	valine-tRNA ligase activity
A3862_RS03600	COG1657	PFAM Prenyltransferase squalene oxidase
A3862_RS03605	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A3862_RS03610	COG1562	ergosterol biosynthetic process
A3862_RS03615	COG1562	ergosterol biosynthetic process
A3862_RS03620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS03625	COG0360	Binds together with S18 to 16S ribosomal RNA
A3862_RS03630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A3862_RS03640	COG0359	binds to the 23S rRNA
A3862_RS03645	COG0305	Participates in initiation and elongation during chromosome replication
A3862_RS03655	COG3386	PFAM SMP-30 Gluconolaconase
A3862_RS03675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A3862_RS03690	COG1496	oxidoreductase activity
A3862_RS03695	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3862_RS03705	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS03715	COG0322	excinuclease ABC activity
A3862_RS03720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3862_RS03775	COG0297	glycogen (starch) synthase activity
A3862_RS03785	COG3206	protein involved in exopolysaccharide biosynthesis
A3862_RS03785	COG0489	protein tyrosine kinase activity
A3862_RS03790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A3862_RS03825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3862_RS03835	COG0483	inositol monophosphate 1-phosphatase activity
A3862_RS03845	COG1278	Cold shock
A3862_RS03860	COG0693	protein deglycase activity
A3862_RS03900	COG3300	MHYT domain
A3862_RS03900	COG5001	Diguanylate cyclase
A3862_RS03910	COG1132	(ABC) transporter
A3862_RS03930	COG1692	metallophosphoesterase
A3862_RS03935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3862_RS03960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A3862_RS03970	COG0438	transferase activity, transferring glycosyl groups
A3862_RS03990	COG0303	'Molybdopterin
A3862_RS03995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A3862_RS04015	COG0142	geranyltranstransferase activity
A3862_RS04025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A3862_RS04040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3862_RS04050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3862_RS04055	COG2917	probably involved in intracellular septation
A3862_RS04060	COG0552	protein localization to endoplasmic reticulum
A3862_RS04065	COG0564	pseudouridine synthase activity
A3862_RS04070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3862_RS04075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A3862_RS04085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3862_RS04090	COG0180	Tryptophanyl-tRNA synthetase
A3862_RS04100	COG4106	trans-aconitate 2-methyltransferase activity
A3862_RS04105	COG0840	transmembrane signaling receptor activity
A3862_RS04115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A3862_RS04125	COG0625	glutathione transferase activity
A3862_RS04145	COG0028	Belongs to the TPP enzyme family
A3862_RS04150	COG0154	amidase activity
A3862_RS04155	COG0418	dihydroorotase activity
A3862_RS04160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3862_RS04165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A3862_RS04170	COG3246	L-lysine catabolic process to acetate
A3862_RS04215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3862_RS04345	COG1657	PFAM Prenyltransferase squalene oxidase
A3862_RS04365	COG3383	formate dehydrogenase (NAD+) activity
A3862_RS04420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3862_RS04430	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3862_RS04430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3862_RS04450	COG4977	sequence-specific DNA binding
A3862_RS04465	COG0531	amino acid
A3862_RS04480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3862_RS04485	COG2218	PFAM glutamate synthase alpha subunit domain protein
A3862_RS04490	COG0069	glutamate synthase activity
A3862_RS04530	COG0517	IMP dehydrogenase activity
A3862_RS04535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3862_RS04615	COG3360	Dodecin
A3862_RS04635	COG0626	cystathionine gamma-synthase activity
A3862_RS04865	COG2814	Major facilitator Superfamily
A3862_RS04870	COG1566	PFAM secretion protein HlyD family protein
A3862_RS04910	COG4221	oxidoreductase activity
A3862_RS04910	COG0604	alcohol dehydrogenase
A3862_RS04910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A3862_RS04910	COG3321	synthase
A3862_RS04925	COG1902	pentaerythritol trinitrate reductase activity
A3862_RS04930	COG1309	transcriptional regulator
A3862_RS04965	COG3436	PFAM IS66 Orf2 family protein
A3862_RS04970	COG4372	Transposase
A3862_RS04985	COG0702	epimerase
A3862_RS04990	COG0583	DNA-binding transcription factor activity
A3862_RS04995	COG2353	YceI-like domain
A3862_RS05010	COG2514	catechol 2,3-dioxygenase activity
A3862_RS05030	COG0693	protein deglycase activity
A3862_RS05040	COG1902	pentaerythritol trinitrate reductase activity
A3862_RS05070	COG3920	Histidine kinase
A3862_RS05070	COG3920	Histidine kinase
A3862_RS05070	COG2202	Pas domain
A3862_RS05070	COG2202	Pas domain
A3862_RS05080	COG0784	Response regulator, receiver
A3862_RS05080	COG4191	Histidine kinase
A3862_RS05095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3862_RS05130	COG0477	Major facilitator Superfamily
A3862_RS05140	COG0163	prenyltransferase activity
A3862_RS05165	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS05175	COG1309	transcriptional regulator
A3862_RS05185	COG0709	Synthesizes selenophosphate from selenide and ATP
A3862_RS05190	COG0709	Synthesizes selenophosphate from selenide and ATP
A3862_RS05195	COG1960	acyl-CoA dehydrogenase activity
A3862_RS05205	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A3862_RS05225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3862_RS05225	COG0551	DNA topoisomerase type I activity
A3862_RS05250	COG1802	Transcriptional regulator
A3862_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS05260	COG0604	alcohol dehydrogenase
A3862_RS05260	COG3321	synthase
A3862_RS05265	COG0028	Belongs to the TPP enzyme family
A3862_RS05285	COG0410	ABC transporter
A3862_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS05295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3862_RS05300	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A3862_RS05310	COG4974	Belongs to the 'phage' integrase family
A3862_RS05435	COG4191	Histidine kinase
A3862_RS05440	COG4566	intracellular signal transduction
A3862_RS05450	COG1017	nitric oxide dioxygenase activity
A3862_RS05450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3862_RS05505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS05515	COG0402	S-adenosylhomocysteine deaminase activity
A3862_RS05525	COG2271	Major facilitator Superfamily
A3862_RS05530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3862_RS05535	COG0583	DNA-binding transcription factor activity
A3862_RS05550	COG0243	molybdopterin cofactor binding
A3862_RS05560	COG1846	Transcriptional regulator
A3862_RS05565	COG1921	L-seryl-tRNASec selenium transferase activity
A3862_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS05600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3862_RS05605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A3862_RS05610	COG0740	serine-type endopeptidase activity
A3862_RS05615	COG0544	peptidyl-prolyl cis-trans isomerase activity
A3862_RS05630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3862_RS05630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3862_RS05635	COG0347	Belongs to the P(II) protein family
A3862_RS05645	COG0174	glutamine synthetase
A3862_RS05650	COG0174	glutamine synthetase
A3862_RS05660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3862_RS05710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A3862_RS05715	COG1596	polysaccharide export
A3862_RS05715	COG1555	photosystem II stabilization
A3862_RS05740	COG1585	Membrane protein implicated in regulation of membrane protease activity
A3862_RS05745	COG0330	HflC and HflK could
A3862_RS05750	COG0297	glycogen (starch) synthase activity
A3862_RS05790	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A3862_RS05810	COG1960	acyl-CoA dehydrogenase activity
A3862_RS05815	COG2887	Belongs to the helicase family. UvrD subfamily
A3862_RS05820	COG0431	NADPH-dependent FMN reductase
A3862_RS05820	COG1053	succinate dehydrogenase
A3862_RS05820	COG3976	FMN-binding domain protein
A3862_RS05835	COG3493	citrate carrier protein
A3862_RS05875	COG0601	transmembrane transport
A3862_RS05885	COG0444	Belongs to the ABC transporter superfamily
A3862_RS05920	COG0436	Aminotransferase
A3862_RS05940	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3862_RS05945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3862_RS05950	COG4191	Histidine kinase
A3862_RS05960	COG2226	methyltransferase
A3862_RS05965	COG0482	sulfurtransferase activity
A3862_RS05985	COG1766	The M ring may be actively involved in energy transduction
A3862_RS05990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A3862_RS06000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A3862_RS06005	COG2204	response regulator
A3862_RS06030	COG1338	Plays a role in the flagellum-specific transport system
A3862_RS06065	COG2030	dehydratase
A3862_RS06085	COG1131	(ABC) transporter
A3862_RS06105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3862_RS06105	COG0519	Catalyzes the synthesis of GMP from XMP
A3862_RS06130	COG1324	tolerance protein
A3862_RS06135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3862_RS06155	COG1278	Cold shock
A3862_RS06165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3862_RS06170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3862_RS06175	COG0628	permease
A3862_RS06190	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS06225	COG0784	Response regulator, receiver
A3862_RS06235	COG5487	UPF0391 membrane protein
A3862_RS06240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3862_RS06270	COG3383	formate dehydrogenase (NAD+) activity
A3862_RS06285	COG0625	glutathione transferase activity
A3862_RS06290	COG3088	subunit of a heme lyase
A3862_RS06295	COG1138	Cytochrome C-type biogenesis protein
A3862_RS06300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A3862_RS06305	COG4235	cytochrome complex assembly
A3862_RS06420	COG3591	Belongs to the peptidase S1B family
A3862_RS06425	COG0783	Belongs to the Dps family
A3862_RS06440	COG4695	Portal protein
A3862_RS06480	COG1078	dGTPase activity
A3862_RS06500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3862_RS06505	COG0586	Pfam SNARE associated Golgi protein
A3862_RS06530	COG0758	DNA mediated transformation
A3862_RS06550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3862_RS06565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3862_RS06630	COG5001	Diguanylate cyclase
A3862_RS06630	COG3300	MHYT domain
A3862_RS06855	COG2205	protein histidine kinase activity
A3862_RS06880	COG1999	signal sequence binding
A3862_RS06885	COG0492	ferredoxin-NADP+ reductase activity
A3862_RS06890	COG1285	pathogenesis
A3862_RS06910	COG0583	DNA-binding transcription factor activity
A3862_RS06970	COG5001	Diguanylate cyclase
A3862_RS06970	COG3300	MHYT domain
A3862_RS06980	COG0473	3-isopropylmalate dehydrogenase activity
A3862_RS06995	COG1201	RNA secondary structure unwinding
A3862_RS07005	COG1074	ATP-dependent DNA helicase activity
A3862_RS07015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3862_RS07040	COG3920	Histidine kinase
A3862_RS07040	COG2202	Pas domain
A3862_RS07040	COG3920	Histidine kinase
A3862_RS07040	COG2202	Pas domain
A3862_RS07050	COG0784	Response regulator, receiver
A3862_RS07050	COG4191	Histidine kinase
A3862_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS07060	COG0783	Belongs to the Dps family
A3862_RS07070	COG4251	negative regulation of phosphorylation
A3862_RS07090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS07130	COG0028	Belongs to the TPP enzyme family
A3862_RS07135	COG3386	PFAM SMP-30 Gluconolaconase
A3862_RS07165	COG0583	DNA-binding transcription factor activity
A3862_RS07200	COG2855	membrane
A3862_RS07205	COG0588	phosphoglycerate mutase activity
A3862_RS07240	COG3920	Histidine kinase
A3862_RS07245	COG2166	iron-sulfur cluster assembly
A3862_RS07305	COG3546	catalase activity
A3862_RS07320	COG0210	DNA helicase
A3862_RS07325	COG1702	phosphate starvation-inducible protein PhoH
A3862_RS07355	COG0840	transmembrane signaling receptor activity
A3862_RS07355	COG2972	Histidine kinase
A3862_RS07365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A3862_RS07375	COG0494	nUDIX hydrolase
A3862_RS07395	COG0400	carboxylic ester hydrolase activity
A3862_RS07400	COG0346	lactoylglutathione lyase activity
A3862_RS07405	COG0583	DNA-binding transcription factor activity
A3862_RS07410	COG2188	Transcriptional regulator
A3862_RS07425	COG1294	oxidase, subunit
A3862_RS07430	COG1271	oxidase subunit
A3862_RS07445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS07450	COG0765	amino acid transport
A3862_RS07455	COG1126	abc transporter atp-binding protein
A3862_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS07530	COG4957	zinc ion binding
A3862_RS07540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A3862_RS07550	COG1732	Glycine betaine
A3862_RS07555	COG1174	glycine betaine transport
A3862_RS07560	COG1125	glycine betaine transport
A3862_RS07565	COG1174	glycine betaine transport
A3862_RS07600	COG4957	zinc ion binding
A3862_RS07645	COG0583	DNA-binding transcription factor activity
A3862_RS07650	COG2271	Major facilitator Superfamily
A3862_RS07660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3862_RS07665	COG0114	fumarate hydratase activity
A3862_RS07670	COG0028	Belongs to the TPP enzyme family
A3862_RS07680	COG0579	oxidoreductase
A3862_RS07685	COG1271	oxidase subunit
A3862_RS07690	COG1294	oxidase, subunit
A3862_RS07705	COG1566	PFAM secretion protein HlyD family protein
A3862_RS07710	COG0667	Aldo Keto reductase
A3862_RS07715	COG1741	Belongs to the pirin family
A3862_RS07730	COG4957	zinc ion binding
A3862_RS07780	COG2814	Major facilitator Superfamily
A3862_RS07785	COG2188	Transcriptional regulator
A3862_RS07795	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A3862_RS07800	COG1473	amidohydrolase
A3862_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
A3862_RS07820	COG0583	DNA-binding transcription factor activity
A3862_RS07830	COG1522	sequence-specific DNA binding
A3862_RS07835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3862_RS07840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3862_RS07850	COG2201	protein-glutamate methylesterase activity
A3862_RS07860	COG0835	chemotaxis
A3862_RS07865	COG0840	transmembrane signaling receptor activity
A3862_RS07870	COG0784	Response regulator, receiver
A3862_RS07870	COG0835	chemotaxis
A3862_RS07875	COG0643	Histidine kinase
A3862_RS07875	COG2198	Histidine kinase
A3862_RS07880	COG0840	transmembrane signaling receptor activity
A3862_RS07890	COG0745	RESPONSE REGULATOR receiver
A3862_RS07900	COG3224	Antibiotic biosynthesis monooxygenase
A3862_RS07905	COG0590	tRNA wobble adenosine to inosine editing
A3862_RS07915	COG0129	dihydroxy-acid dehydratase activity
A3862_RS07975	COG5001	Diguanylate cyclase
A3862_RS07980	COG0789	Transcriptional regulator
A3862_RS07985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3862_RS08000	COG5001	Diguanylate cyclase
A3862_RS08040	COG0154	amidase activity
A3862_RS08045	COG4302	ethanolamine ammonia-lyase activity
A3862_RS08070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3862_RS08075	COG1349	DNA-binding transcription factor activity
A3862_RS08080	COG4172	Belongs to the ABC transporter superfamily
A3862_RS08090	COG0601	transmembrane transport
A3862_RS08095	COG0747	negative chemotaxis
A3862_RS08110	COG0765	amino acid transport
A3862_RS08115	COG0765	amino acid transport
A3862_RS08120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS08125	COG0251	oxidation-reduction process
A3862_RS08130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3862_RS08160	COG2814	Major facilitator Superfamily
A3862_RS08165	COG1566	PFAM secretion protein HlyD family protein
A3862_RS08170	COG1309	transcriptional regulator
A3862_RS08185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3862_RS08190	COG0408	coproporphyrinogen oxidase activity
A3862_RS08200	COG4957	zinc ion binding
A3862_RS08230	COG2205	protein histidine kinase activity
A3862_RS08260	COG4948	Mandelate Racemase Muconate Lactonizing
A3862_RS08295	COG0277	FAD linked oxidase domain protein
A3862_RS08300	COG0247	lactate metabolic process
A3862_RS08305	COG1530	ribonuclease E activity
A3862_RS08305	COG1530	ribonuclease E activity
A3862_RS08310	COG0840	transmembrane signaling receptor activity
A3862_RS08315	COG3648	Uricase
A3862_RS08315	COG3195	allantoin biosynthetic process
A3862_RS08330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A3862_RS08340	COG0302	gtp cyclohydrolase
A3862_RS08345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3862_RS08350	COG1752	Esterase of the alpha-beta hydrolase superfamily
A3862_RS08360	COG2239	Acts as a magnesium transporter
A3862_RS08380	COG1999	signal sequence binding
A3862_RS08390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A3862_RS08450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A3862_RS08455	COG3639	organic phosphonate transmembrane transporter activity
A3862_RS08460	COG3639	organic phosphonate transmembrane transporter activity
A3862_RS08465	COG1473	amidohydrolase
A3862_RS08475	COG0601	transmembrane transport
A3862_RS08480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS08500	COG4558	Periplasmic binding protein
A3862_RS08505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3862_RS08510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3862_RS08515	COG4771	TonB-dependent receptor
A3862_RS08525	COG1215	transferase activity, transferring glycosyl groups
A3862_RS08535	COG2755	lipolytic protein G-D-S-L family
A3862_RS08535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3862_RS08550	COG2273	Hydrolase Family 16
A3862_RS08555	COG1215	transferase activity, transferring glycosyl groups
A3862_RS08580	COG2197	response regulator
A3862_RS08585	COG0438	transferase activity, transferring glycosyl groups
A3862_RS08605	COG0673	inositol 2-dehydrogenase activity
A3862_RS08620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A3862_RS08625	COG0726	polysaccharide deacetylase
A3862_RS08630	COG1216	Glycosyl transferase, family 2
A3862_RS08640	COG1442	glycosyl transferase family 8
A3862_RS08660	COG1215	transferase activity, transferring glycosyl groups
A3862_RS08665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A3862_RS08695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A3862_RS08710	COG2207	Transcriptional regulator
A3862_RS08735	COG3477	response to acidic pH
A3862_RS08760	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3862_RS08770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS08775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS08780	COG1116	anion transmembrane transporter activity
A3862_RS08780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS08790	COG2207	Transcriptional regulator
A3862_RS08790	COG1609	Transcriptional regulator
A3862_RS08795	COG1902	pentaerythritol trinitrate reductase activity
A3862_RS08805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3862_RS08820	COG0411	ABC transporter
A3862_RS08850	COG0583	DNA-binding transcription factor activity
A3862_RS08855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A3862_RS08860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3862_RS08885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3862_RS08890	COG3178	'Phosphotransferase
A3862_RS08905	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A3862_RS08930	COG2879	small protein
A3862_RS08935	COG1966	Carbon starvation protein
A3862_RS08940	COG2084	Dehydrogenase
A3862_RS08945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A3862_RS08950	COG0560	Phosphoserine phosphatase
A3862_RS08950	COG3830	Belongs to the UPF0237 family
A3862_RS08960	COG0330	HflC and HflK could
A3862_RS08965	COG0330	HflC and HflK could
A3862_RS08995	COG2124	cytochrome p450
A3862_RS08995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A3862_RS09000	COG0114	fumarate hydratase activity
A3862_RS09025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3862_RS09030	COG4191	Histidine kinase
A3862_RS09030	COG0784	Response regulator, receiver
A3862_RS09040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3862_RS09065	COG0165	Argininosuccinate lyase
A3862_RS09070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3862_RS09075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A3862_RS09080	COG2192	nodulation
A3862_RS09105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A3862_RS09115	COG3920	Histidine kinase
A3862_RS09120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3862_RS09125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A3862_RS09130	COG1396	sequence-specific DNA binding
A3862_RS09140	COG4783	chaperone-mediated protein folding
A3862_RS09145	COG0625	glutathione transferase activity
A3862_RS09155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS09160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3862_RS09165	COG2080	2 iron, 2 sulfur cluster binding
A3862_RS09195	COG4608	Belongs to the ABC transporter superfamily
A3862_RS09200	COG0444	Belongs to the ABC transporter superfamily
A3862_RS09205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS09210	COG0601	transmembrane transport
A3862_RS09215	COG0747	negative chemotaxis
A3862_RS09225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS09235	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS09245	COG1760	l-serine dehydratase
A3862_RS09255	COG2030	dehydratase
A3862_RS09290	COG3237	CsbD-like
A3862_RS09295	COG3237	CsbD-like
A3862_RS09310	COG0183	Belongs to the thiolase family
A3862_RS09315	COG1960	acyl-CoA dehydrogenase activity
A3862_RS09325	COG0546	phosphoglycolate phosphatase activity
A3862_RS09335	COG3300	MHYT domain
A3862_RS09335	COG5001	Diguanylate cyclase
A3862_RS09360	COG4191	Histidine kinase
A3862_RS09360	COG0784	Response regulator, receiver
A3862_RS09365	COG2205	protein histidine kinase activity
A3862_RS09385	COG0154	amidase activity
A3862_RS09430	COG2094	Belongs to the DNA glycosylase MPG family
A3862_RS09445	COG0583	DNA-binding transcription factor activity
A3862_RS09485	COG5001	Diguanylate cyclase
A3862_RS09485	COG3300	MHYT domain
A3862_RS09500	COG0626	cystathionine gamma-synthase activity
A3862_RS09515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3862_RS09520	COG1982	Orn Lys Arg decarboxylase major
A3862_RS09535	COG3038	cytochrome b561
A3862_RS09540	COG2353	YceI-like domain
A3862_RS09595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3862_RS09600	COG4191	Histidine kinase
A3862_RS09600	COG0784	Response regulator, receiver
A3862_RS09615	COG2134	cdp-diacylglycerol pyrophosphatase
A3862_RS09625	COG0747	negative chemotaxis
A3862_RS09655	COG4957	zinc ion binding
A3862_RS09660	COG2855	membrane
A3862_RS09665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS09675	COG3964	amidohydrolase
A3862_RS09680	COG4608	Belongs to the ABC transporter superfamily
A3862_RS09685	COG0444	Belongs to the ABC transporter superfamily
A3862_RS09690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS09695	COG0601	transmembrane transport
A3862_RS09720	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A3862_RS09730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3862_RS09735	COG0047	phosphoribosylformylglycinamidine synthase activity
A3862_RS09760	COG0438	transferase activity, transferring glycosyl groups
A3862_RS09775	COG5001	Diguanylate cyclase
A3862_RS09810	COG1132	(ABC) transporter
A3862_RS09815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A3862_RS09830	COG5001	Diguanylate cyclase
A3862_RS09830	COG5002	protein histidine kinase activity
A3862_RS09830	COG3447	MASE1 domain protein
A3862_RS09835	COG1196	nuclear chromosome segregation
A3862_RS09835	COG3264	Mechanosensitive ion channel
A3862_RS09850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3862_RS09865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3862_RS09875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3862_RS09880	COG0037	tRNA processing
A3862_RS09890	COG2885	chlorophyll binding
A3862_RS09925	COG0277	FAD linked oxidase domain protein
A3862_RS09930	COG4957	zinc ion binding
A3862_RS09935	COG4239	(ABC) transporter, permease
A3862_RS09965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3862_RS09985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A3862_RS09990	COG0328	RNA-DNA hybrid ribonuclease activity
A3862_RS09995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A3862_RS10000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A3862_RS10025	COG1360	Flagellar Motor Protein
A3862_RS10030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A3862_RS10045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A3862_RS10050	COG0840	transmembrane signaling receptor activity
A3862_RS10050	COG3290	protein histidine kinase activity
A3862_RS10055	COG1285	pathogenesis
A3862_RS10060	COG0714	Associated with various cellular activities
A3862_RS10110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3862_RS10115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A3862_RS10120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A3862_RS10125	COG1981	membrane
A3862_RS10135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A3862_RS10140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A3862_RS10150	COG0124	histidyl-tRNA synthetase
A3862_RS10160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A3862_RS10165	COG0424	maF-like protein
A3862_RS10175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3862_RS10180	COG0237	dephospho-CoA kinase activity
A3862_RS10190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3862_RS10205	COG3766	membrane
A3862_RS10215	COG0754	glutathionylspermidine amidase activity
A3862_RS10245	COG4251	negative regulation of phosphorylation
A3862_RS10250	COG0784	Response regulator, receiver
A3862_RS10270	COG4773	Receptor
A3862_RS10275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS10280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3862_RS10285	COG2080	2 iron, 2 sulfur cluster binding
A3862_RS10295	COG3300	MHYT domain
A3862_RS10295	COG5001	Diguanylate cyclase
A3862_RS10305	COG2954	triphosphatase activity
A3862_RS10330	COG0747	negative chemotaxis
A3862_RS10340	COG0346	lactoylglutathione lyase activity
A3862_RS10365	COG4957	zinc ion binding
A3862_RS10415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS10435	COG2011	ABC-type metal ion transport system permease component
A3862_RS10440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3862_RS10490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3862_RS10495	COG5001	Diguanylate cyclase
A3862_RS10500	COG2124	cytochrome p450
A3862_RS10510	COG4993	Dehydrogenase
A3862_RS10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS10520	COG2010	Cytochrome c
A3862_RS10530	COG0714	Associated with various cellular activities
A3862_RS10575	COG2197	response regulator
A3862_RS10595	COG5001	Diguanylate cyclase
A3862_RS10595	COG3300	MHYT domain
A3862_RS10600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3862_RS10645	COG0193	aminoacyl-tRNA hydrolase activity
A3862_RS10650	COG0012	GTP binding
A3862_RS10660	COG0667	Aldo Keto reductase
A3862_RS10665	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3862_RS10670	COG1674	ftsk spoiiie
A3862_RS10675	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS10680	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS10720	COG1253	flavin adenine dinucleotide binding
A3862_RS10730	COG0495	leucyl-tRNA aminoacylation
A3862_RS10735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A3862_RS10755	COG2171	N-acyltransferase activity
A3862_RS10770	COG4774	siderophore transport
A3862_RS10805	COG0357	Ribosomal RNA small subunit methyltransferase G
A3862_RS10810	COG0445	tRNA wobble uridine modification
A3862_RS10835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A3862_RS10845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A3862_RS10855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A3862_RS10865	COG0488	(ABC) transporter
A3862_RS10875	COG2321	neutral zinc metallopeptidase
A3862_RS10880	COG1573	uracil-dna glycosylase
A3862_RS10900	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A3862_RS10910	COG1846	Transcriptional regulator
A3862_RS10915	COG0745	RESPONSE REGULATOR receiver
A3862_RS10950	COG1595	DNA-templated transcription, initiation
A3862_RS10960	COG0038	chloride channel
A3862_RS10965	COG0431	NADPH-dependent FMN reductase
A3862_RS10980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3862_RS11055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A3862_RS11065	COG1554	hydrolase, family 65, central catalytic
A3862_RS11070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3862_RS11160	COG0459	protein refolding
A3862_RS11165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A3862_RS11170	COG1162	GTPase activity
A3862_RS11205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3862_RS11205	COG1017	nitric oxide dioxygenase activity
A3862_RS11230	COG0463	Glycosyl transferase, family 2
A3862_RS11235	COG0019	diaminopimelate decarboxylase activity
A3862_RS11270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A3862_RS11280	COG0784	Response regulator, receiver
A3862_RS11280	COG2198	Histidine kinase
A3862_RS11280	COG0643	Histidine kinase
A3862_RS11285	COG0835	chemotaxis
A3862_RS11290	COG0745	RESPONSE REGULATOR receiver
A3862_RS11295	COG2201	protein-glutamate methylesterase activity
A3862_RS11300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A3862_RS11310	COG0252	asparaginase activity
A3862_RS11330	COG0517	IMP dehydrogenase activity
A3862_RS11330	COG0516	GMP reductase activity
A3862_RS11335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS11340	COG0842	Transport permease protein
A3862_RS11340	COG1129	ABC transporter
A3862_RS11345	COG0842	Transport permease protein
A3862_RS11350	COG3243	poly(R)-hydroxyalkanoic acid synthase
A3862_RS11375	COG0589	response to stress
A3862_RS11380	COG0517	IMP dehydrogenase activity
A3862_RS11385	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS11485	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A3862_RS11520	COG0793	Belongs to the peptidase S41A family
A3862_RS11555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3862_RS11575	COG4566	intracellular signal transduction
A3862_RS11580	COG4191	Histidine kinase
A3862_RS11620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A3862_RS11620	COG0037	tRNA processing
A3862_RS11675	COG0473	3-isopropylmalate dehydrogenase activity
A3862_RS11685	COG1722	exodeoxyribonuclease VII activity
A3862_RS11695	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A3862_RS11700	COG2818	Glycosylase
A3862_RS11720	COG0354	folic acid binding
A3862_RS11735	COG1051	belongs to the nudix hydrolase family
A3862_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS11755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A3862_RS11760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3862_RS11765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3862_RS11775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A3862_RS11785	COG3920	Histidine kinase
A3862_RS11785	COG2202	Pas domain
A3862_RS11790	COG2204	response regulator
A3862_RS11795	COG1902	pentaerythritol trinitrate reductase activity
A3862_RS11805	COG0546	phosphoglycolate phosphatase activity
A3862_RS11810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3862_RS11825	COG0416	fatty acid biosynthetic process
A3862_RS11830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3862_RS11835	COG0776	regulation of translation
A3862_RS11855	COG2766	serine protein kinase
A3862_RS11860	COG2718	Belongs to the UPF0229 family
A3862_RS11865	COG2719	SpoVR family
A3862_RS11880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3862_RS11880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3862_RS11885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A3862_RS11890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3862_RS11920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3862_RS11920	COG0475	glutathione-regulated potassium exporter activity
A3862_RS11940	COG0259	pyridoxamine-phosphate oxidase activity
A3862_RS11945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A3862_RS11955	COG1178	ABC-type Fe3 transport system permease component
A3862_RS11970	COG3842	ATPase activity
A3862_RS11990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3862_RS12020	COG3158	transport of potassium into the cell
A3862_RS12025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A3862_RS12035	COG0386	Belongs to the glutathione peroxidase family
A3862_RS12060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3862_RS12065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3862_RS12075	COG3963	phosphatidate phosphatase activity
A3862_RS12080	COG0484	heat shock protein binding
A3862_RS12085	COG0443	Heat shock 70 kDa protein
A3862_RS12095	COG1678	Uncharacterized ACR, COG1678
A3862_RS12100	COG0678	peroxiredoxin activity
A3862_RS12105	COG0586	Pfam SNARE associated Golgi protein
A3862_RS12115	COG4957	zinc ion binding
A3862_RS12125	COG0783	Belongs to the Dps family
A3862_RS12135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3862_RS12135	COG2755	lipolytic protein G-D-S-L family
A3862_RS12145	COG0300	oxidoreductase activity
A3862_RS12155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A3862_RS12165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3862_RS12170	COG2943	transferase activity, transferring hexosyl groups
A3862_RS12175	COG1388	LysM domain
A3862_RS12175	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS12190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3862_RS12200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3862_RS12210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3862_RS12215	COG4221	oxidoreductase activity
A3862_RS12220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A3862_RS12225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A3862_RS12230	COG1160	GTP binding
A3862_RS12285	COG2124	cytochrome p450
A3862_RS12290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3862_RS12310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A3862_RS12315	COG1704	LemA family
A3862_RS12330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3862_RS12335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3862_RS12355	COG4957	zinc ion binding
A3862_RS12365	COG0306	phosphate transporter
A3862_RS12380	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A3862_RS12390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A3862_RS12395	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A3862_RS12400	COG3639	organic phosphonate transmembrane transporter activity
A3862_RS12410	COG2188	Transcriptional regulator
A3862_RS12420	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A3862_RS12425	COG3626	phosphonate metabolism
A3862_RS12430	COG3627	carbon phosphorus lyase activity
A3862_RS12435	COG4107	phosphonate C-P lyase system protein PhnK
A3862_RS12440	COG4778	phosphonate C-P lyase system protein PhnL
A3862_RS12445	COG3454	Phosphonate metabolism
A3862_RS12450	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A3862_RS12460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3862_RS12475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A3862_RS12480	COG0250	Participates in transcription elongation, termination and antitermination
A3862_RS12485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3862_RS12490	COG0081	regulation of translation
A3862_RS12500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A3862_RS12505	COG0222	ribosome binding
A3862_RS12510	COG0085	RNA polymerase activity
A3862_RS12515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3862_RS12530	COG0604	alcohol dehydrogenase
A3862_RS12535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3862_RS12540	COG0583	DNA-binding transcription factor activity
A3862_RS12545	COG0655	NAD(P)H dehydrogenase (quinone) activity
A3862_RS12550	COG0009	L-threonylcarbamoyladenylate synthase
A3862_RS12555	COG1960	acyl-CoA dehydrogenase activity
A3862_RS12560	COG1024	Enoyl-CoA hydratase
A3862_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS12570	COG1032	radical SAM domain protein
A3862_RS12585	COG0598	Magnesium transport protein CorA
A3862_RS12595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3862_RS12605	COG2032	superoxide dismutase activity
A3862_RS12610	COG1607	acyl-coa hydrolase
A3862_RS12630	COG0243	molybdopterin cofactor binding
A3862_RS12635	COG0513	Belongs to the DEAD box helicase family
A3862_RS12685	COG2897	thiosulfate sulfurtransferase activity
A3862_RS12720	COG4964	Belongs to the GSP D family
A3862_RS12735	COG1454	alcohol dehydrogenase
A3862_RS12750	COG1960	acyl-CoA dehydrogenase activity
A3862_RS12755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A3862_RS12775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3862_RS12810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3862_RS12825	COG3265	gluconokinase activity
A3862_RS12845	COG0683	leucine binding
A3862_RS12855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3862_RS12870	COG0415	Belongs to the DNA photolyase family
A3862_RS12885	COG5487	UPF0391 membrane protein
A3862_RS12905	COG0537	adenosine 5'-monophosphoramidase activity
A3862_RS12925	COG1674	ftsk spoiiie
A3862_RS12940	COG0708	Exodeoxyribonuclease III
A3862_RS12945	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS12975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3862_RS13060	COG0629	single-stranded DNA binding
A3862_RS13065	COG2130	NADP-dependent
A3862_RS13080	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A3862_RS13085	COG0667	Aldo Keto reductase
A3862_RS13090	COG0779	Required for maturation of 30S ribosomal subunits
A3862_RS13105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3862_RS13110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A3862_RS13115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3862_RS13120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3862_RS13125	COG4251	negative regulation of phosphorylation
A3862_RS13145	COG0194	GDP metabolic process
A3862_RS13150	COG1561	YicC-like family, N-terminal region
A3862_RS13160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3862_RS13165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A3862_RS13185	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A3862_RS13215	COG4581	dead DEAH box helicase
A3862_RS13235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A3862_RS13285	COG1793	dna ligase
A3862_RS13290	COG0432	Pfam Uncharacterised protein family UPF0047
A3862_RS13340	COG1252	NADH dehydrogenase
A3862_RS13345	COG0625	glutathione transferase activity
A3862_RS13350	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3862_RS13355	COG0531	amino acid
A3862_RS13375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3862_RS13380	COG0438	transferase activity, transferring glycosyl groups
A3862_RS13390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3862_RS13395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3862_RS13400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A3862_RS13405	COG3404	Formiminotransferase-cyclodeaminase
A3862_RS13410	COG0045	succinate-CoA ligase (ADP-forming) activity
A3862_RS13415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3862_RS13420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A3862_RS13440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A3862_RS13470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A3862_RS13475	COG1247	-acetyltransferase
A3862_RS13490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A3862_RS13495	COG3474	cytochrome
A3862_RS13500	COG2814	Major facilitator Superfamily
A3862_RS13525	COG4174	ABC transporter (Permease)
A3862_RS13530	COG4166	transmembrane transport
A3862_RS13535	COG4166	transmembrane transport
A3862_RS13560	COG0714	Associated with various cellular activities
A3862_RS13570	COG1216	Glycosyl transferase, family 2
A3862_RS13570	COG0438	transferase activity, transferring glycosyl groups
A3862_RS13580	COG3594	Acyltransferase
A3862_RS13590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3862_RS13595	COG1946	Acyl-CoA thioesterase
A3862_RS13600	COG0347	Belongs to the P(II) protein family
A3862_RS13605	COG0004	ammonium transporteR
A3862_RS13610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A3862_RS13620	COG0336	Belongs to the RNA methyltransferase TrmD family
A3862_RS13645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3862_RS13655	COG0228	four-way junction DNA binding
A3862_RS13660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A3862_RS13690	COG0596	Alpha beta hydrolase
A3862_RS13710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3862_RS13725	COG2814	Major facilitator Superfamily
A3862_RS13750	COG0673	inositol 2-dehydrogenase activity
A3862_RS13765	COG0438	transferase activity, transferring glycosyl groups
A3862_RS13785	COG5002	protein histidine kinase activity
A3862_RS13790	COG0625	glutathione transferase activity
A3862_RS13800	COG0789	Transcriptional regulator
A3862_RS13805	COG1473	amidohydrolase
A3862_RS13810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A3862_RS13820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3862_RS13830	COG2223	nitrite transmembrane transporter activity
A3862_RS13835	COG0583	DNA-binding transcription factor activity
A3862_RS13840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A3862_RS13860	COG0557	exoribonuclease II activity
A3862_RS13870	COG0247	lactate metabolic process
A3862_RS13870	COG0277	FAD linked oxidase domain protein
A3862_RS13875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3862_RS13885	COG4191	Histidine kinase
A3862_RS13885	COG0784	Response regulator, receiver
A3862_RS13895	COG0745	RESPONSE REGULATOR receiver
A3862_RS13915	COG0583	DNA-binding transcription factor activity
A3862_RS13920	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A3862_RS13945	COG0300	oxidoreductase activity
A3862_RS13950	COG0217	transcriptional regulatory protein
A3862_RS13960	COG2169	Transcriptional regulator
A3862_RS13960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3862_RS13980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3862_RS13990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A3862_RS13995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A3862_RS14005	COG2137	regulation of response to DNA damage stimulus
A3862_RS14015	COG1573	uracil-dna glycosylase
A3862_RS14030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3862_RS14030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3862_RS14035	COG4191	Histidine kinase
A3862_RS14035	COG0784	Response regulator, receiver
A3862_RS14040	COG3321	synthase
A3862_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS14040	COG0604	alcohol dehydrogenase
A3862_RS14045	COG0840	transmembrane signaling receptor activity
A3862_RS14050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3862_RS14060	COG0477	Major facilitator Superfamily
A3862_RS14065	COG2066	Belongs to the glutaminase family
A3862_RS14070	COG1132	(ABC) transporter
A3862_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS14110	COG2814	Major facilitator Superfamily
A3862_RS14115	COG2198	Histidine kinase
A3862_RS14115	COG2205	protein histidine kinase activity
A3862_RS14115	COG0784	Response regulator, receiver
A3862_RS14145	COG5328	Belongs to the UPF0262 family
A3862_RS14150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A3862_RS14170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A3862_RS14180	COG0156	8-amino-7-oxononanoate synthase activity
A3862_RS14185	COG0483	inositol monophosphate 1-phosphatase activity
A3862_RS14190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3862_RS14195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A3862_RS14200	COG0594	ribonuclease P activity
A3862_RS14205	COG0706	membrane insertase activity
A3862_RS14210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3862_RS14220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A3862_RS14260	COG1216	Glycosyl transferase, family 2
A3862_RS14260	COG0438	transferase activity, transferring glycosyl groups
A3862_RS14270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3862_RS14275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3862_RS14310	COG0745	RESPONSE REGULATOR receiver
A3862_RS14315	COG2205	protein histidine kinase activity
A3862_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS14325	COG3237	CsbD-like
A3862_RS14330	COG1703	isobutyryl-CoA mutase activity
A3862_RS14350	COG2979	Protein of unknown function (DUF533)
A3862_RS14360	COG0436	Aminotransferase
A3862_RS14385	COG3608	succinylglutamate desuccinylase aspartoacylase
A3862_RS14385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A3862_RS14440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A3862_RS14445	COG0736	holo-[acyl-carrier-protein] synthase activity
A3862_RS14450	COG0681	Belongs to the peptidase S26 family
A3862_RS14455	COG0571	ribonuclease III activity
A3862_RS14460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A3862_RS14465	COG2813	Specifically methylates the guanine in position
A3862_RS14470	COG1187	pseudouridine synthase activity
A3862_RS14475	COG0052	Belongs to the universal ribosomal protein uS2 family
A3862_RS14480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A3862_RS14485	COG0528	UMP kinase activity
A3862_RS14490	COG0233	cytoplasmic translational termination
A3862_RS14500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A3862_RS14505	COG1309	transcriptional regulator
A3862_RS14520	COG0750	zinc metalloprotease
A3862_RS14525	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3862_RS14530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3862_RS14535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3862_RS14540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3862_RS14550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3862_RS14570	COG4178	(ABC) transporter
A3862_RS14575	COG0800	Aldolase
A3862_RS14580	COG0129	dihydroxy-acid dehydratase activity
A3862_RS14605	COG2205	protein histidine kinase activity
A3862_RS14630	COG1132	(ABC) transporter
A3862_RS14640	COG2202	Pas domain
A3862_RS14640	COG3920	Histidine kinase
A3862_RS14655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS14665	COG1609	Transcriptional regulator
A3862_RS14675	COG3622	Belongs to the hyi family
A3862_RS14700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A3862_RS14715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS14725	COG0387	Pfam Sodium calcium exchanger
A3862_RS14730	COG0513	Belongs to the DEAD box helicase family
A3862_RS14780	COG4957	zinc ion binding
A3862_RS14795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3862_RS14800	COG0159	tryptophan synthase activity
A3862_RS14805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A3862_RS14810	COG0285	dihydrofolate synthase activity
A3862_RS14825	COG1074	ATP-dependent DNA helicase activity
A3862_RS14835	COG0850	regulation of cytokinetic process
A3862_RS14840	COG2894	cell division
A3862_RS14845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A3862_RS14855	COG2124	cytochrome p450
A3862_RS14860	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A3862_RS14865	COG1217	gtp-binding protein TYPA
A3862_RS14890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3862_RS14895	COG2358	TRAP transporter, solute receptor (TAXI family
A3862_RS14925	COG2951	lytic endotransglycosylase activity
A3862_RS14930	COG0235	Class ii aldolase
A3862_RS14935	COG1984	allophanate hydrolase subunit 2
A3862_RS14940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3862_RS14945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3862_RS14950	COG2814	Major facilitator Superfamily
A3862_RS14955	COG4336	lyase activity
A3862_RS14960	COG0583	DNA-binding transcription factor activity
A3862_RS14975	COG1802	Transcriptional regulator
A3862_RS14995	COG1129	ABC transporter
A3862_RS15010	COG4160	amino acid transport
A3862_RS15020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A3862_RS15030	COG4977	sequence-specific DNA binding
A3862_RS15035	COG4302	ethanolamine ammonia-lyase activity
A3862_RS15100	COG0625	glutathione transferase activity
A3862_RS15105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3862_RS15105	COG1017	nitric oxide dioxygenase activity
A3862_RS15130	COG3920	Histidine kinase
A3862_RS15130	COG2202	Pas domain
A3862_RS15135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS15150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS15155	COG1116	anion transmembrane transporter activity
A3862_RS15175	COG3307	-O-antigen
A3862_RS15220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A3862_RS15260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3862_RS15275	COG0730	response to heat
A3862_RS15300	COG0450	alkyl hydroperoxide reductase
A3862_RS15305	COG1595	DNA-templated transcription, initiation
A3862_RS15315	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A3862_RS15325	COG1960	acyl-CoA dehydrogenase activity
A3862_RS15330	COG1024	Enoyl-CoA hydratase
A3862_RS15330	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS15335	COG0183	Belongs to the thiolase family
A3862_RS15340	COG0789	Transcriptional regulator
A3862_RS15370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3862_RS15375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3862_RS15380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A3862_RS15395	COG4447	cellulose binding
A3862_RS15400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3862_RS15400	COG0546	phosphoglycolate phosphatase activity
A3862_RS15435	COG0411	ABC transporter
A3862_RS15490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A3862_RS15495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS15500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS15520	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS15525	COG0747	negative chemotaxis
A3862_RS15535	COG1984	allophanate hydrolase subunit 2
A3862_RS15540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3862_RS15565	COG0765	amino acid transport
A3862_RS15580	COG0006	proline dipeptidase activity
A3862_RS15590	COG1802	Transcriptional regulator
A3862_RS15610	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A3862_RS15625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3862_RS15640	COG2072	flavoprotein involved in K transport
A3862_RS15655	COG2144	transferase activity, transferring acyl groups
A3862_RS15805	COG3920	Histidine kinase
A3862_RS15810	COG0784	Response regulator, receiver
A3862_RS15810	COG2205	protein histidine kinase activity
A3862_RS15810	COG2198	Histidine kinase
A3862_RS15815	COG4191	Histidine kinase
A3862_RS15815	COG0784	Response regulator, receiver
A3862_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS15840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS15845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3862_RS15850	COG2080	2 iron, 2 sulfur cluster binding
A3862_RS15875	COG2855	membrane
A3862_RS15880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS15885	COG0583	DNA-binding transcription factor activity
A3862_RS15925	COG1595	DNA-templated transcription, initiation
A3862_RS15930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3862_RS15935	COG4191	Histidine kinase
A3862_RS15935	COG0784	Response regulator, receiver
A3862_RS15940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3862_RS15950	COG3300	MHYT domain
A3862_RS15950	COG5001	Diguanylate cyclase
A3862_RS15960	COG0840	transmembrane signaling receptor activity
A3862_RS15975	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS16005	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS16010	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS16045	COG5001	Diguanylate cyclase
A3862_RS16045	COG4251	negative regulation of phosphorylation
A3862_RS16045	COG3706	GGDEF domain
A3862_RS16045	COG2203	Gaf domain
A3862_RS16065	COG0784	Response regulator, receiver
A3862_RS16065	COG4191	Histidine kinase
A3862_RS16085	COG0784	Response regulator, receiver
A3862_RS16085	COG0643	Histidine kinase
A3862_RS16085	COG2198	Histidine kinase
A3862_RS16090	COG0745	RESPONSE REGULATOR receiver
A3862_RS16095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A3862_RS16105	COG2201	protein-glutamate methylesterase activity
A3862_RS16115	COG0840	transmembrane signaling receptor activity
A3862_RS16135	COG4191	Histidine kinase
A3862_RS16135	COG0784	Response regulator, receiver
A3862_RS16140	COG4191	Histidine kinase
A3862_RS16140	COG0784	Response regulator, receiver
A3862_RS16235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3862_RS16260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A3862_RS16270	COG1403	HNH endonuclease
A3862_RS16295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A3862_RS16305	COG0656	L-ascorbic acid biosynthetic process
A3862_RS16310	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A3862_RS16320	COG1671	Belongs to the UPF0178 family
A3862_RS16340	COG0848	biopolymer transport protein
A3862_RS16360	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS16375	COG0438	transferase activity, transferring glycosyl groups
A3862_RS16380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A3862_RS16390	COG0653	protein targeting
A3862_RS16395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3862_RS16395	COG0072	phenylalanine-tRNA ligase activity
A3862_RS16400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A3862_RS16405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A3862_RS16410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A3862_RS16415	COG0438	transferase activity, transferring glycosyl groups
A3862_RS16425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3862_RS16430	COG0101	tRNA pseudouridine synthase activity
A3862_RS16435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3862_RS16440	COG0242	peptide deformylase activity
A3862_RS16445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A3862_RS16450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A3862_RS16455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A3862_RS16460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A3862_RS16480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3862_RS16545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3862_RS16555	COG0606	chelatase, subunit chli
A3862_RS16585	COG1968	undecaprenyl-diphosphatase activity
A3862_RS16595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3862_RS16605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3862_RS16610	COG1121	(ABC) transporter
A3862_RS16615	COG0735	belongs to the Fur family
A3862_RS16620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3862_RS16630	COG1396	sequence-specific DNA binding
A3862_RS16635	COG1797	cobyrinic acid a,c-diamide synthase activity
A3862_RS16640	COG2875	Belongs to the precorrin methyltransferase family
A3862_RS16720	COG0504	CTP synthase activity
A3862_RS16735	COG0149	triose-phosphate isomerase activity
A3862_RS16740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3862_RS16745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A3862_RS16755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3862_RS16760	COG0134	indole-3-glycerol-phosphate synthase activity
A3862_RS16765	COG0315	cyclic pyranopterin monophosphate synthase activity
A3862_RS16770	COG0303	'Molybdopterin
A3862_RS16800	COG0481	GTPase activity
A3862_RS16815	COG0745	RESPONSE REGULATOR receiver
A3862_RS16820	COG2205	protein histidine kinase activity
A3862_RS16830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3862_RS16830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3862_RS16835	COG5006	permease, DMT superfamily
A3862_RS16840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A3862_RS16845	COG0659	secondary active sulfate transmembrane transporter activity
A3862_RS16860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A3862_RS16870	COG0438	transferase activity, transferring glycosyl groups
A3862_RS16905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3862_RS16920	COG0604	alcohol dehydrogenase
A3862_RS16920	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS16920	COG3321	synthase
A3862_RS16950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A3862_RS16955	COG2271	Major facilitator Superfamily
A3862_RS16960	COG2721	sulfolactate sulfo-lyase activity
A3862_RS16985	COG0747	negative chemotaxis
A3862_RS16995	COG0277	FAD linked oxidase domain protein
A3862_RS17015	COG2354	Protein conserved in bacteria
A3862_RS17020	COG2197	response regulator
A3862_RS17085	COG5001	Diguanylate cyclase
A3862_RS17090	COG0824	Thioesterase
A3862_RS17095	COG0583	DNA-binding transcription factor activity
A3862_RS17100	COG1301	dicarboxylic acid transport
A3862_RS17105	COG3257	ureidoglycine aminohydrolase activity
A3862_RS17110	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A3862_RS17115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3862_RS17120	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS17135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3862_RS17140	COG2084	Dehydrogenase
A3862_RS17145	COG3958	Transketolase
A3862_RS17150	COG3959	Transketolase, thiamine diphosphate binding domain
A3862_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS17160	COG0583	DNA-binding transcription factor activity
A3862_RS17195	COG2183	response to ionizing radiation
A3862_RS17210	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3862_RS17215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A3862_RS17220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3862_RS17240	COG2884	Cell division ATP-binding protein ftsE
A3862_RS17270	COG1309	transcriptional regulator
A3862_RS17280	COG0840	transmembrane signaling receptor activity
A3862_RS17285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3862_RS17295	COG3321	synthase
A3862_RS17295	COG0604	alcohol dehydrogenase
A3862_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS17305	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS17310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A3862_RS17315	COG2086	electron transfer activity
A3862_RS17355	COG0424	maF-like protein
A3862_RS17360	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A3862_RS17375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3862_RS17380	COG3750	Belongs to the UPF0335 family
A3862_RS17390	COG0477	Major facilitator Superfamily
A3862_RS17410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3862_RS17415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3862_RS17420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3862_RS17430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A3862_RS17435	COG0792	nuclease activity
A3862_RS17445	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS17475	COG0247	lactate metabolic process
A3862_RS17480	COG1139	Iron-sulfur cluster binding protein
A3862_RS17495	COG0129	dihydroxy-acid dehydratase activity
A3862_RS17525	COG1494	fructose-1,6-bisphosphatase
A3862_RS17530	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS17530	COG1388	LysM domain
A3862_RS17535	COG2223	nitrite transmembrane transporter activity
A3862_RS17540	COG2271	Major facilitator Superfamily
A3862_RS17545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3862_RS17550	COG1024	Enoyl-CoA hydratase
A3862_RS17570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3862_RS17575	COG1802	Transcriptional regulator
A3862_RS17585	COG1802	Transcriptional regulator
A3862_RS17590	COG0247	lactate metabolic process
A3862_RS17590	COG0277	FAD linked oxidase domain protein
A3862_RS17595	COG0129	dihydroxy-acid dehydratase activity
A3862_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS17605	COG1802	Transcriptional regulator
A3862_RS17625	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS17630	COG3246	L-lysine catabolic process to acetate
A3862_RS17640	COG0277	FAD linked oxidase domain protein
A3862_RS17650	COG3842	ATPase activity
A3862_RS17665	COG0395	ABC-type sugar transport system, permease component
A3862_RS17675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3862_RS17680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS17690	COG4166	transmembrane transport
A3862_RS17720	COG0583	DNA-binding transcription factor activity
A3862_RS17725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3862_RS17730	COG0488	(ABC) transporter
A3862_RS17735	COG2199	diguanylate cyclase activity
A3862_RS17735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A3862_RS17740	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A3862_RS17750	COG3842	ATPase activity
A3862_RS17755	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3862_RS17760	COG1177	transmembrane transport
A3862_RS17765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3862_RS17780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A3862_RS17785	COG0830	nickel cation binding
A3862_RS17790	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A3862_RS17795	COG0804	urea catabolic process
A3862_RS17800	COG0831	urea catabolic process
A3862_RS17800	COG0832	Belongs to the urease beta subunit family
A3862_RS17835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS17840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3862_RS17860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A3862_RS17865	COG1764	response to oxidative stress
A3862_RS17870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A3862_RS17875	COG0129	dihydroxy-acid dehydratase activity
A3862_RS17890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS17900	COG1233	COG1233 Phytoene dehydrogenase and related
A3862_RS17905	COG1562	ergosterol biosynthetic process
A3862_RS17910	COG0181	hydroxymethylbilane synthase activity
A3862_RS17930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3862_RS17945	COG2202	Pas domain
A3862_RS17945	COG3920	Histidine kinase
A3862_RS17950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS17960	COG0747	negative chemotaxis
A3862_RS17975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A3862_RS17980	COG0438	transferase activity, transferring glycosyl groups
A3862_RS18005	COG0142	geranyltranstransferase activity
A3862_RS18010	COG0500	methyltransferase
A3862_RS18015	COG1063	alcohol dehydrogenase
A3862_RS18020	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A3862_RS18025	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3862_RS18030	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3862_RS18070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3862_RS18070	COG0574	Belongs to the PEP-utilizing enzyme family
A3862_RS18085	COG2989	Protein conserved in bacteria
A3862_RS18100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A3862_RS18125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A3862_RS18140	COG1802	Transcriptional regulator
A3862_RS18150	COG0235	Class ii aldolase
A3862_RS18155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3862_RS18160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3862_RS18180	COG0784	Response regulator, receiver
A3862_RS18185	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A3862_RS18195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS18215	COG2154	pterin-4-alpha-carbinolamine dehydratase
A3862_RS18230	COG1116	anion transmembrane transporter activity
A3862_RS18245	COG0316	Belongs to the HesB IscA family
A3862_RS18250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A3862_RS18260	COG0018	arginyl-trna synthetase
A3862_RS18270	COG1472	Belongs to the glycosyl hydrolase 3 family
A3862_RS18275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A3862_RS18280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A3862_RS18285	COG0805	protein transport
A3862_RS18295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A3862_RS18300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A3862_RS18310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A3862_RS18315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3862_RS18315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3862_RS18325	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3862_RS18330	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS18340	COG4770	biotin carboxylase activity
A3862_RS18360	COG1254	Belongs to the acylphosphatase family
A3862_RS18375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A3862_RS18385	COG0625	glutathione transferase activity
A3862_RS18390	COG1509	lysine 2,3-aminomutase activity
A3862_RS18395	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A3862_RS18400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A3862_RS18410	COG1278	Cold shock
A3862_RS18425	COG0412	Dienelactone hydrolase
A3862_RS18505	COG1131	(ABC) transporter
A3862_RS18535	COG0297	glycogen (starch) synthase activity
A3862_RS18540	COG1272	protein, Hemolysin III
A3862_RS18545	COG1612	heme a metabolic process
A3862_RS18560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A3862_RS18565	COG0439	Biotin carboxylase
A3862_RS18570	COG0511	ligase activity, forming carbon-carbon bonds
A3862_RS18580	COG0436	Aminotransferase
A3862_RS18585	COG0546	phosphoglycolate phosphatase activity
A3862_RS18595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3862_RS18620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A3862_RS18665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3862_RS18675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3862_RS18700	COG2226	methyltransferase
A3862_RS18710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3862_RS18720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A3862_RS18725	COG0784	Response regulator, receiver
A3862_RS18725	COG2205	protein histidine kinase activity
A3862_RS18730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A3862_RS18735	COG2226	methyltransferase
A3862_RS18740	COG0473	3-isopropylmalate dehydrogenase activity
A3862_RS18745	COG0288	reversible hydration of carbon dioxide
A3862_RS18755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3862_RS18785	COG3387	PFAM Glycoside hydrolase 15-related
A3862_RS18805	COG0840	transmembrane signaling receptor activity
A3862_RS18820	COG0829	nickel cation binding
A3862_RS18880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3862_RS18895	COG0539	negative regulation of cytoplasmic translation
A3862_RS18900	COG0616	signal peptide processing
A3862_RS18905	COG0776	regulation of translation
A3862_RS18915	COG0135	phosphoribosylanthranilate isomerase activity
A3862_RS18950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3862_RS18955	COG0438	transferase activity, transferring glycosyl groups
A3862_RS18965	COG1396	sequence-specific DNA binding
A3862_RS18970	COG5001	Diguanylate cyclase
A3862_RS18970	COG3300	MHYT domain
A3862_RS18975	COG1999	signal sequence binding
A3862_RS18980	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3862_RS19000	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A3862_RS19005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3862_RS19010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3862_RS19050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A3862_RS19075	COG1289	transmembrane transporter activity
A3862_RS19085	COG1566	PFAM secretion protein HlyD family protein
A3862_RS19105	COG3243	poly(R)-hydroxyalkanoic acid synthase
A3862_RS19115	COG1454	alcohol dehydrogenase
A3862_RS19130	COG0583	DNA-binding transcription factor activity
A3862_RS19145	COG5002	protein histidine kinase activity
A3862_RS19145	COG0784	Response regulator, receiver
A3862_RS19145	COG2205	protein histidine kinase activity
A3862_RS19155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3862_RS19160	COG0739	heme binding
A3862_RS19160	COG0741	lytic transglycosylase activity
A3862_RS19160	COG1196	nuclear chromosome segregation
A3862_RS19195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3862_RS19205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3862_RS19210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3862_RS19220	COG0523	cobalamin synthesis protein
A3862_RS19225	COG1686	Belongs to the peptidase S11 family
A3862_RS19230	COG0602	queuosine metabolic process
A3862_RS19250	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A3862_RS19255	COG1088	dTDP-glucose 4,6-dehydratase activity
A3862_RS19260	COG1091	dTDP-4-dehydrorhamnose reductase activity
A3862_RS19300	COG2202	Pas domain
A3862_RS19300	COG2205	protein histidine kinase activity
A3862_RS19305	COG0308	aminopeptidase N
A3862_RS19320	COG0275	rRNA processing
A3862_RS19335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3862_RS19340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A3862_RS19345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A3862_RS19365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A3862_RS19370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A3862_RS19375	COG2852	Protein conserved in bacteria
A3862_RS19380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A3862_RS19385	COG1181	Belongs to the D-alanine--D-alanine ligase family
A3862_RS19390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A3862_RS19395	COG0849	cell division
A3862_RS19400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3862_RS19410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3862_RS19440	COG0581	inorganic phosphate transmembrane transporter activity
A3862_RS19445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3862_RS19450	COG0704	Plays a role in the regulation of phosphate uptake
A3862_RS19455	COG0745	RESPONSE REGULATOR receiver
A3862_RS19465	COG0006	proline dipeptidase activity
A3862_RS19465	COG0006	proline dipeptidase activity
A3862_RS19480	COG2264	protein methyltransferase activity
A3862_RS19490	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3862_RS19495	COG4149	molybdate abc transporter
A3862_RS19505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A3862_RS19525	COG1473	amidohydrolase
A3862_RS19550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A3862_RS19555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3862_RS19570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3862_RS19580	COG2967	ApaG domain
A3862_RS19585	COG0717	Belongs to the dCTP deaminase family
A3862_RS19590	COG1522	sequence-specific DNA binding
A3862_RS19600	COG0363	glucosamine-6-phosphate deaminase activity
A3862_RS19605	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A3862_RS19610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A3862_RS19620	COG3387	PFAM Glycoside hydrolase 15-related
A3862_RS19630	COG3707	response regulator
A3862_RS19640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3862_RS19645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3862_RS19650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A3862_RS19655	COG0243	molybdopterin cofactor binding
A3862_RS19660	COG1648	precorrin-2 dehydrogenase activity
A3862_RS19660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A3862_RS19670	COG2816	NAD+ diphosphatase activity
A3862_RS19690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3862_RS19700	COG0288	reversible hydration of carbon dioxide
A3862_RS19705	COG1051	belongs to the nudix hydrolase family
A3862_RS19745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A3862_RS19750	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3862_RS19760	COG3737	Protein of unknown function (DUF498/DUF598)
A3862_RS19770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3862_RS19775	COG1862	Preprotein translocase
A3862_RS19780	COG0596	Alpha beta hydrolase
A3862_RS19820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A3862_RS19840	COG0154	amidase activity
A3862_RS19855	COG0314	molybdopterin synthase activity
A3862_RS19865	COG1126	abc transporter atp-binding protein
A3862_RS19870	COG0765	amino acid transport
A3862_RS19875	COG0765	amino acid transport
A3862_RS19885	COG0683	leucine binding
A3862_RS19920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS19925	COG3683	transport system, periplasmic component
A3862_RS19940	COG0588	phosphoglycerate mutase activity
A3862_RS19955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3862_RS19965	COG0477	Major facilitator Superfamily
A3862_RS19980	COG1815	bacterial-type flagellum-dependent cell motility
A3862_RS19985	COG1558	bacterial-type flagellum-dependent cell motility
A3862_RS19990	COG1677	Flagellar hook-basal body complex protein FliE
A3862_RS19995	COG1987	bacterial-type flagellum assembly
A3862_RS20000	COG1684	flagellar biosynthetic protein fliR
A3862_RS20005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3862_RS20015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A3862_RS20020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A3862_RS20025	COG0255	Belongs to the universal ribosomal protein uL29 family
A3862_RS20030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A3862_RS20035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3862_RS20040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A3862_RS20045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3862_RS20050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3862_RS20055	COG0089	rRNA binding
A3862_RS20060	COG0088	Forms part of the polypeptide exit tunnel
A3862_RS20065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3862_RS20070	COG0051	transcription antitermination factor activity, RNA binding
A3862_RS20075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3862_RS20080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3862_RS20085	COG0049	tRNA binding
A3862_RS20090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A3862_RS20095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3862_RS20100	COG0765	amino acid transport
A3862_RS20105	COG0765	amino acid transport
A3862_RS20115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3862_RS20120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A3862_RS20125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3862_RS20130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A3862_RS20135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3862_RS20140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3862_RS20145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3862_RS20150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3862_RS20155	COG1841	ribosomal large subunit assembly
A3862_RS20160	COG0200	Binds to the 23S rRNA
A3862_RS20165	COG0201	protein transport
A3862_RS20170	COG0563	adenylate kinase activity
A3862_RS20185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3862_RS20190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A3862_RS20200	COG0202	RNA polymerase activity
A3862_RS20205	COG0203	ribosomal protein L17
A3862_RS20215	COG4191	Histidine kinase
A3862_RS20265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3862_RS20270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A3862_RS20275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A3862_RS20280	COG2867	negative regulation of translational initiation
A3862_RS20305	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS20315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A3862_RS20315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A3862_RS20320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3862_RS20330	COG2204	response regulator
A3862_RS20340	COG0626	cystathionine gamma-synthase activity
A3862_RS20350	COG0463	Glycosyl transferase, family 2
A3862_RS20370	COG2962	Rard protein
A3862_RS20375	COG0784	Response regulator, receiver
A3862_RS20375	COG2205	protein histidine kinase activity
A3862_RS20385	COG3300	MHYT domain
A3862_RS20385	COG5001	Diguanylate cyclase
A3862_RS20400	COG3191	aminopeptidase activity
A3862_RS20405	COG2084	Dehydrogenase
A3862_RS20420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3862_RS20425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A3862_RS20455	COG0746	molybdenum cofactor guanylyltransferase activity
A3862_RS20460	COG0489	protein tyrosine kinase activity
A3862_RS20485	COG0628	permease
A3862_RS20490	COG0483	inositol monophosphate 1-phosphatase activity
A3862_RS20500	COG3106	COG3106 Predicted ATPase
A3862_RS20505	COG3768	UPF0283 membrane protein
A3862_RS20530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3862_RS20545	COG1301	dicarboxylic acid transport
A3862_RS20550	COG1940	carbohydrate kinase activity
A3862_RS20555	COG3781	membrane
A3862_RS20560	COG0406	alpha-ribazole phosphatase activity
A3862_RS20565	COG2226	methyltransferase
A3862_RS20610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3862_RS20620	COG0028	Belongs to the TPP enzyme family
A3862_RS20680	COG0583	DNA-binding transcription factor activity
A3862_RS20685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS20690	COG2855	membrane
A3862_RS20750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3862_RS20750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3862_RS20755	COG4974	Belongs to the 'phage' integrase family
A3862_RS20785	COG0297	glycogen (starch) synthase activity
A3862_RS20795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS20800	COG1132	(ABC) transporter
A3862_RS20805	COG1309	transcriptional regulator
A3862_RS20845	COG3237	CsbD-like
A3862_RS20860	COG3237	CsbD-like
A3862_RS20875	COG1032	radical SAM domain protein
A3862_RS20960	COG3546	catalase activity
A3862_RS21000	COG1132	(ABC) transporter
A3862_RS21025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3862_RS21045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3862_RS21050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3862_RS21055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3862_RS21060	COG0649	NAD binding
A3862_RS21070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A3862_RS21080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3862_RS21085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3862_RS21095	COG0713	ATP synthesis coupled electron transport
A3862_RS21110	COG1007	ATP synthesis coupled electron transport
A3862_RS21125	COG0346	lactoylglutathione lyase activity
A3862_RS21135	COG0442	prolyl-tRNA aminoacylation
A3862_RS21140	COG4591	ABC-type transport system involved in lipoprotein release permease component
A3862_RS21145	COG1136	(ABC) transporter
A3862_RS21155	COG1819	glycosyl
A3862_RS21170	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A3862_RS21180	COG1381	Involved in DNA repair and RecF pathway recombination
A3862_RS21185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3862_RS21195	COG0372	Belongs to the citrate synthase family
A3862_RS21200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3862_RS21210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3862_RS21240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A3862_RS21315	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
A3862_RS21325	COG4245	von Willebrand factor, type A
A3862_RS21335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3862_RS21390	COG0477	Major facilitator Superfamily
A3862_RS21400	COG3023	N-Acetylmuramoyl-L-alanine amidase
A3862_RS21405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A3862_RS21415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A3862_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS21440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3862_RS21455	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3862_RS21460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3862_RS21465	COG0747	negative chemotaxis
A3862_RS21475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3862_RS21480	COG0720	synthase
A3862_RS21485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3862_RS21510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A3862_RS21530	COG0352	thiamine-phosphate diphosphorylase activity
A3862_RS21535	COG0351	phosphomethylpyrimidine kinase
A3862_RS21540	COG1396	sequence-specific DNA binding
A3862_RS21550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A3862_RS21550	COG3218	ABC-type transport auxiliary lipoprotein component
A3862_RS21555	COG1127	ABC transporter
A3862_RS21560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A3862_RS21565	COG2814	Major facilitator Superfamily
A3862_RS21590	COG0633	Ferredoxin
A3862_RS21630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3862_RS21635	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS21640	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS21645	COG3246	L-lysine catabolic process to acetate
A3862_RS21660	COG0667	Aldo Keto reductase
A3862_RS21665	COG0583	DNA-binding transcription factor activity
A3862_RS21690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3862_RS21700	COG5265	(ABC) transporter
A3862_RS21715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3862_RS21750	COG4957	zinc ion binding
A3862_RS21825	COG3753	Protein conserved in bacteria
A3862_RS21830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3862_RS21835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3862_RS21845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A3862_RS21850	COG1758	RNA polymerase activity
A3862_RS21870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A3862_RS21875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3862_RS21885	COG0753	catalase activity
A3862_RS21920	COG2895	sulfate adenylyltransferase (ATP) activity
A3862_RS21920	COG0529	Catalyzes the synthesis of activated sulfate
A3862_RS21930	COG2813	Specifically methylates the guanine in position
A3862_RS21930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3862_RS21935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3862_RS21955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3862_RS21960	COG0287	Prephenate dehydrogenase
A3862_RS21965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3862_RS21970	COG0133	tryptophan synthase activity
A3862_RS22005	COG0825	malonyl-CoA metabolic process
A3862_RS22020	COG2814	Major facilitator Superfamily
A3862_RS22025	COG3034	peptidoglycan biosynthetic process
A3862_RS22030	COG0401	homolog of Blt101
A3862_RS22035	COG2010	Cytochrome c
A3862_RS22035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS22050	COG0644	oxidoreductase
A3862_RS22055	COG2211	Major facilitator Superfamily
A3862_RS22060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3862_RS22080	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3862_RS22085	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3862_RS22090	COG1429	ligase activity, forming nitrogen-metal bonds
A3862_RS22095	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A3862_RS22105	COG2814	Major facilitator Superfamily
A3862_RS22130	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A3862_RS22140	COG0156	8-amino-7-oxononanoate synthase activity
A3862_RS22150	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A3862_RS22160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3862_RS22175	COG2124	cytochrome p450
A3862_RS22190	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS22195	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS22220	COG1129	ABC transporter
A3862_RS22230	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3862_RS22235	COG0683	leucine binding
A3862_RS22245	COG1086	Polysaccharide biosynthesis protein
A3862_RS22265	COG0739	heme binding
A3862_RS22270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3862_RS22280	COG2304	oxidoreductase activity
A3862_RS22295	COG0346	lactoylglutathione lyase activity
A3862_RS22300	COG0612	Peptidase, M16
A3862_RS22305	COG0612	Peptidase, M16
A3862_RS22315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A3862_RS22320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A3862_RS22340	COG0436	Aminotransferase
A3862_RS22345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS22355	COG2895	sulfate adenylyltransferase (ATP) activity
A3862_RS22360	COG0175	sulfate reduction
A3862_RS22365	COG0175	sulfate reduction
A3862_RS22370	COG1522	sequence-specific DNA binding
A3862_RS22375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A3862_RS22380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3862_RS22405	COG2721	sulfolactate sulfo-lyase activity
A3862_RS22410	COG2084	Dehydrogenase
A3862_RS22420	COG0583	DNA-binding transcription factor activity
A3862_RS22425	COG0683	leucine binding
A3862_RS22440	COG3226	Transcriptional regulator
A3862_RS22455	COG4521	taurine ABC transporter
A3862_RS22460	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A3862_RS22465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS22475	COG3685	Protein conserved in bacteria
A3862_RS22490	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS22505	COG0284	orotidine-5'-phosphate decarboxylase activity
A3862_RS22510	COG1573	uracil-dna glycosylase
A3862_RS22525	COG2205	protein histidine kinase activity
A3862_RS22525	COG2202	Pas domain
A3862_RS22535	COG3300	MHYT domain
A3862_RS22535	COG5001	Diguanylate cyclase
A3862_RS22540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A3862_RS22545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3862_RS22550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3862_RS22555	COG3585	molybdate ion transport
A3862_RS22570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3862_RS22580	COG0033	Phosphoglucomutase
A3862_RS22600	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A3862_RS22605	COG1845	cytochrome c oxidase, subunit III
A3862_RS22610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3862_RS22615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A3862_RS22620	COG0477	Major facilitator Superfamily
A3862_RS22625	COG1216	Glycosyl transferase, family 2
A3862_RS22625	COG0438	transferase activity, transferring glycosyl groups
A3862_RS22675	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS22685	COG0235	Class ii aldolase
A3862_RS22690	COG0583	DNA-binding transcription factor activity
A3862_RS22695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A3862_RS22700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3862_RS22705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A3862_RS22710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A3862_RS22725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A3862_RS22735	COG4786	Flagellar basal body rod
A3862_RS22740	COG1157	protein secretion by the type III secretion system
A3862_RS22760	COG5442	Flagellar protein FlaF
A3862_RS22775	COG5443	negative regulation of bacterial-type flagellum assembly
A3862_RS22780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A3862_RS22790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3862_RS22830	COG1815	bacterial-type flagellum-dependent cell motility
A3862_RS22835	COG1558	bacterial-type flagellum-dependent cell motility
A3862_RS22840	COG1677	Flagellar hook-basal body complex protein FliE
A3862_RS22845	COG4786	Flagellar basal body rod
A3862_RS22875	COG1338	Plays a role in the flagellum-specific transport system
A3862_RS22950	COG4957	zinc ion binding
A3862_RS22960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3862_RS22975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3862_RS22980	COG0596	Alpha beta hydrolase
A3862_RS22985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3862_RS23020	COG4977	sequence-specific DNA binding
A3862_RS23025	COG2852	Protein conserved in bacteria
A3862_RS23035	COG2301	Belongs to the HpcH HpaI aldolase family
A3862_RS23045	COG2223	nitrite transmembrane transporter activity
A3862_RS23050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3862_RS23060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A3862_RS23070	COG1335	isochorismatase
A3862_RS23090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3862_RS23115	COG3685	Protein conserved in bacteria
A3862_RS23130	COG3956	TIGRFAM MazG family protein
A3862_RS23185	COG1914	H( )-stimulated, divalent metal cation uptake system
A3862_RS23280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A3862_RS23290	COG0366	Alpha amylase catalytic
A3862_RS23295	COG0366	Alpha amylase catalytic
A3862_RS23300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A3862_RS23305	COG0297	glycogen (starch) synthase activity
A3862_RS23310	COG0366	Alpha amylase catalytic
A3862_RS23315	COG0058	SHG alpha-glucan phosphorylase activity
A3862_RS23350	COG0612	Peptidase, M16
A3862_RS23370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS23375	COG1335	isochorismatase
A3862_RS23380	COG0251	oxidation-reduction process
A3862_RS23385	COG2267	carboxylic ester hydrolase activity
A3862_RS23415	COG0110	maltose O-acetyltransferase activity
A3862_RS23420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3862_RS23425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A3862_RS23440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3862_RS23450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A3862_RS23455	COG2223	nitrite transmembrane transporter activity
A3862_RS23475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3862_RS23500	COG0659	secondary active sulfate transmembrane transporter activity
A3862_RS23515	COG3920	Histidine kinase
A3862_RS23530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3862_RS23570	COG3616	Alanine racemase, N-terminal domain
A3862_RS23575	COG2423	ornithine cyclodeaminase activity
A3862_RS23585	COG1061	Type III restriction enzyme res subunit
A3862_RS23605	COG3920	Histidine kinase
A3862_RS23620	COG2080	2 iron, 2 sulfur cluster binding
A3862_RS23625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3862_RS23630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS23640	COG4993	Dehydrogenase
A3862_RS23645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS23650	COG2140	Oxalate decarboxylase
A3862_RS23660	COG0151	Belongs to the GarS family
A3862_RS23670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A3862_RS23680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3862_RS23685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3862_RS23690	COG4957	zinc ion binding
A3862_RS23725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3862_RS23725	COG0321	lipoyl(octanoyl) transferase activity
A3862_RS23730	COG0084	hydrolase, TatD family'
A3862_RS23750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3862_RS23755	COG1686	Belongs to the peptidase S11 family
A3862_RS23780	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS23795	COG4774	siderophore transport
A3862_RS23805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A3862_RS23805	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A3862_RS23810	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A3862_RS23820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3862_RS23825	COG1923	regulation of RNA biosynthetic process
A3862_RS23830	COG2204	response regulator
A3862_RS23835	COG5000	phosphorelay sensor kinase activity
A3862_RS23840	COG0673	inositol 2-dehydrogenase activity
A3862_RS23865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3862_RS23875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A3862_RS23900	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS23925	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A3862_RS23930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3862_RS23945	COG1492	cobalamin metabolic process
A3862_RS24020	COG1742	UPF0060 membrane protein
A3862_RS24045	COG0277	FAD linked oxidase domain protein
A3862_RS24110	COG0464	growth
A3862_RS24115	COG0464	growth
A3862_RS24125	COG2197	response regulator
A3862_RS24165	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3862_RS24195	COG0411	ABC transporter
A3862_RS24205	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3862_RS24245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3862_RS24250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3862_RS24255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3862_RS24260	COG1063	alcohol dehydrogenase
A3862_RS24280	COG1595	DNA-templated transcription, initiation
A3862_RS24295	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3862_RS24350	COG0714	Associated with various cellular activities
A3862_RS24355	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A3862_RS24370	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A3862_RS24405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A3862_RS24450	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A3862_RS24455	COG1606	tRNA processing
A3862_RS24460	COG1691	(AIR) carboxylase
A3862_RS24465	COG4989	oxidoreductase activity
A3862_RS24470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3862_RS24515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A3862_RS24565	COG1116	anion transmembrane transporter activity
A3862_RS24570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS24575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS24580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS24585	COG0431	NADPH-dependent FMN reductase
A3862_RS24600	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3862_RS24625	COG2186	Transcriptional regulator
A3862_RS24630	COG0129	dihydroxy-acid dehydratase activity
A3862_RS24660	COG1609	Transcriptional regulator
A3862_RS24665	COG1132	(ABC) transporter
A3862_RS24695	COG3920	Histidine kinase
A3862_RS24725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3862_RS24735	COG1715	Restriction endonuclease
A3862_RS24740	COG0732	type I restriction modification DNA specificity domain
A3862_RS24750	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A3862_RS24845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3862_RS24890	COG2351	hydroxyisourate hydrolase activity
A3862_RS24895	COG0154	amidase activity
A3862_RS24915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3862_RS24920	COG3842	ATPase activity
A3862_RS24930	COG1802	Transcriptional regulator
A3862_RS24940	COG3706	GGDEF domain
A3862_RS24945	COG5002	protein histidine kinase activity
A3862_RS24960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3862_RS25005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3862_RS25010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A3862_RS25015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A3862_RS25030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS25050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3862_RS25090	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS25105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3862_RS25115	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS25145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS25220	COG0586	Pfam SNARE associated Golgi protein
A3862_RS25230	COG1216	Glycosyl transferase, family 2
A3862_RS25270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3862_RS25275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3862_RS25280	COG1832	CoA-binding protein
A3862_RS25330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3862_RS25340	COG0384	phenazine biosynthesis protein PhzF
A3862_RS25355	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A3862_RS25360	COG0586	Pfam SNARE associated Golgi protein
A3862_RS25390	COG0752	glycyl-tRNA synthetase alpha subunit
A3862_RS25400	COG0751	glycine-tRNA ligase activity
A3862_RS25405	COG0235	Class ii aldolase
A3862_RS25410	COG1609	Transcriptional regulator
A3862_RS25415	COG2271	Major facilitator Superfamily
A3862_RS25420	COG2084	Dehydrogenase
A3862_RS25425	COG3622	Belongs to the hyi family
A3862_RS25430	COG3395	kinase activity
A3862_RS25435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS25450	COG0514	ATP-dependent DNA helicase (RecQ)
A3862_RS25455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3862_RS25470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A3862_RS25475	COG0500	methyltransferase
A3862_RS25480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A3862_RS25525	COG0071	Belongs to the small heat shock protein (HSP20) family
A3862_RS25545	COG1830	Aldolase
A3862_RS25555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A3862_RS25560	COG0840	transmembrane signaling receptor activity
A3862_RS25565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3862_RS25565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3862_RS25570	COG0604	alcohol dehydrogenase
A3862_RS25575	COG2824	Alkylphosphonate utilization operon protein PhnA
A3862_RS25600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3862_RS25605	COG4208	sulfate ABC transporter
A3862_RS25615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A3862_RS25630	COG0243	molybdopterin cofactor binding
A3862_RS25630	COG3383	formate dehydrogenase (NAD+) activity
A3862_RS25635	COG0243	molybdopterin cofactor binding
A3862_RS25635	COG3383	formate dehydrogenase (NAD+) activity
A3862_RS25640	COG0437	4 iron, 4 sulfur cluster binding
A3862_RS25645	COG2864	formate dehydrogenase
A3862_RS25675	COG0583	DNA-binding transcription factor activity
A3862_RS25680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3862_RS25690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3862_RS25695	COG1917	Cupin 2, conserved barrel domain protein
A3862_RS25695	COG1396	sequence-specific DNA binding
A3862_RS25710	COG2814	Major facilitator Superfamily
A3862_RS25720	COG3698	Phosphodiester glycosidase
A3862_RS25725	COG1902	pentaerythritol trinitrate reductase activity
A3862_RS25765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3862_RS25785	COG1960	acyl-CoA dehydrogenase activity
A3862_RS25790	COG0183	Belongs to the thiolase family
A3862_RS25795	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3862_RS25795	COG1024	Enoyl-CoA hydratase
A3862_RS25805	COG1024	Enoyl-CoA hydratase
A3862_RS25815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3862_RS25830	COG2226	methyltransferase
A3862_RS25855	COG3034	peptidoglycan biosynthetic process
A3862_RS25860	COG4988	ABC transporter
A3862_RS25870	COG0437	4 iron, 4 sulfur cluster binding
A3862_RS25895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A3862_RS25900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3862_RS25915	COG0121	glutamine amidotransferase
A3862_RS25935	COG1970	mechanosensitive ion channel activity
A3862_RS25940	COG1183	phosphatidylcholine synthase activity
A3862_RS25945	COG0688	phosphatidylethanolamine metabolic process
A3862_RS25955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3862_RS25955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3862_RS25975	COG1376	ErfK ybiS ycfS ynhG family protein
A3862_RS25980	COG0778	Nitroreductase
A3862_RS25990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3862_RS25995	COG0670	Belongs to the BI1 family
A3862_RS26015	COG0577	efflux transmembrane transporter activity
A3862_RS26015	COG1136	(ABC) transporter
A3862_RS26020	COG4181	ATPase activity
A3862_RS26035	COG1072	(Pantothenic acid kinase))
A3862_RS26040	COG0140	phosphoribosyl-ATP diphosphatase activity
A3862_RS26045	COG0540	Belongs to the ATCase OTCase family
A3862_RS26055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS26060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3862_RS26070	COG0187	DNA topoisomerase II activity
A3862_RS26090	COG0513	Belongs to the DEAD box helicase family
A3862_RS26100	COG0316	Belongs to the HesB IscA family
A3862_RS26120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3862_RS26125	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3862_RS26140	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3862_RS26140	COG0022	dehydrogenase e1 component
A3862_RS26145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A3862_RS26150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A3862_RS26165	COG0148	phosphopyruvate hydratase activity
A3862_RS26170	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A3862_RS26180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A3862_RS26185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A3862_RS26195	COG0596	Alpha beta hydrolase
A3862_RS26225	COG3394	polysaccharide catabolic process
A3862_RS26240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3862_RS26270	COG0066	3-isopropylmalate dehydratase activity
A3862_RS26285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3862_RS26290	COG2951	lytic endotransglycosylase activity
A3862_RS26305	COG0335	large ribosomal subunit rRNA binding
A3862_RS26315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A3862_RS26320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3862_RS26325	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS26325	COG0604	alcohol dehydrogenase
A3862_RS26325	COG3321	synthase
A3862_RS26330	COG0156	8-amino-7-oxononanoate synthase activity
A3862_RS26355	COG0300	oxidoreductase activity
A3862_RS26360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3862_RS26360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3862_RS26365	COG1558	bacterial-type flagellum-dependent cell motility
A3862_RS26370	COG0531	amino acid
A3862_RS26385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3862_RS26390	COG1185	polyribonucleotide nucleotidyltransferase activity
A3862_RS26400	COG2261	transglycosylase associated protein
A3862_RS26405	COG0251	oxidation-reduction process
A3862_RS26440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A3862_RS26445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A3862_RS26455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3862_RS26460	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS26465	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3862_RS26475	COG0567	Dehydrogenase, E1 component
A3862_RS26480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3862_RS26485	COG0045	succinate-CoA ligase (ADP-forming) activity
A3862_RS26490	COG0039	L-malate dehydrogenase activity
A3862_RS26500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3862_RS26525	COG4953	penicillin-binding protein 1C
A3862_RS26580	COG0154	amidase activity
A3862_RS26590	COG0028	Belongs to the TPP enzyme family
A3862_RS26615	COG0154	amidase activity
A3862_RS26635	COG1519	Transferase
A3862_RS26640	COG1663	tetraacyldisaccharide 4'-kinase activity
A3862_RS26650	COG0196	riboflavin kinase activity
A3862_RS26655	COG0745	RESPONSE REGULATOR receiver
A3862_RS26675	COG1595	DNA-templated transcription, initiation
A3862_RS26690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A3862_RS26720	COG0189	ligase activity
A3862_RS26740	COG2226	methyltransferase
A3862_RS26750	COG0156	8-amino-7-oxononanoate synthase activity
A3862_RS26770	COG0523	cobalamin synthesis protein
A3862_RS26785	COG4774	siderophore transport
A3862_RS26805	COG0546	phosphoglycolate phosphatase activity
A3862_RS26820	COG0386	Belongs to the glutathione peroxidase family
A3862_RS26830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3862_RS26835	COG4536	flavin adenine dinucleotide binding
A3862_RS26885	COG2835	tetraacyldisaccharide 4'-kinase activity
A3862_RS26895	COG3118	belongs to the thioredoxin family
A3862_RS26905	COG0435	Glutathione S-transferase
A3862_RS26930	COG0671	phosphoesterase, PA-phosphatase related
A3862_RS26940	COG0673	inositol 2-dehydrogenase activity
A3862_RS26945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A3862_RS26955	COG4786	Flagellar basal body rod
A3862_RS26960	COG4786	Flagellar basal body rod
A3862_RS26985	COG4172	Belongs to the ABC transporter superfamily
A3862_RS26990	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A3862_RS27005	COG1335	isochorismatase
A3862_RS27015	COG0657	acetylesterase activity
A3862_RS27025	COG1607	acyl-coa hydrolase
A3862_RS27045	COG0556	nucleotide-excision repair
A3862_RS27060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3862_RS27090	COG0840	transmembrane signaling receptor activity
A3862_RS27105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3862_RS27120	COG1686	Belongs to the peptidase S11 family
A3862_RS27130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A3862_RS27150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A3862_RS27155	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A3862_RS27160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3862_RS27165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A3862_RS27185	COG1392	Phosphate transport regulator
A3862_RS27190	COG0306	phosphate transporter
A3862_RS27235	COG5001	Diguanylate cyclase
A3862_RS27235	COG3300	MHYT domain
A3862_RS27250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3862_RS27255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3862_RS27265	COG3038	cytochrome b561
A3862_RS27275	COG2264	protein methyltransferase activity
A3862_RS27280	COG0438	transferase activity, transferring glycosyl groups
A3862_RS27315	COG2255	four-way junction helicase activity
A3862_RS27325	COG0824	Thioesterase
A3862_RS27335	COG0811	peptide transport
A3862_RS27340	COG0848	biopolymer transport protein
A3862_RS27360	COG2205	protein histidine kinase activity
A3862_RS27365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3862_RS27375	COG3158	transport of potassium into the cell
A3862_RS27380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A3862_RS27385	COG0653	protein targeting
A3862_RS27390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3862_RS27395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A3862_RS27400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A3862_RS27415	COG1024	Enoyl-CoA hydratase
A3862_RS27425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3862_RS27445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3862_RS27450	COG0488	(ABC) transporter
A3862_RS27465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A3862_RS27470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A3862_RS27495	COG0356	it plays a direct role in the translocation of protons across the membrane
A3862_RS27505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A3862_RS27510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A3862_RS27515	COG2116	formate transmembrane transporter activity
A3862_RS27520	COG1058	Belongs to the CinA family
A3862_RS27520	COG1546	Belongs to the CinA family
A3862_RS27525	COG1489	DNA binding
A3862_RS27540	COG0842	Transport permease protein
A3862_RS27545	COG1131	(ABC) transporter
A3862_RS27570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3862_RS27575	COG0719	Fe-S assembly protein
A3862_RS27580	COG0396	ATPase activity
A3862_RS27590	COG0719	Fe-S assembly protein
A3862_RS27595	COG1104	cysteine desulfurase activity
A3862_RS27600	COG2945	thiolester hydrolase activity
A3862_RS27610	COG2873	o-acetylhomoserine
A3862_RS27650	COG1006	Multisubunit Na H antiporter MnhC subunit
A3862_RS27655	COG0651	ATP synthesis coupled electron transport
A3862_RS27875	COG1372	Participates in initiation and elongation during chromosome replication
A3862_RS27875	COG0305	Participates in initiation and elongation during chromosome replication
A3862_RS28065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3862_RS28075	COG4974	Belongs to the 'phage' integrase family
A3862_RS28080	COG1846	Transcriptional regulator
A3862_RS28120	COG0477	Major facilitator Superfamily
A3862_RS28125	COG1570	exodeoxyribonuclease VII activity
A3862_RS28135	COG2267	carboxylic ester hydrolase activity
A3862_RS28155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3862_RS28170	COG0444	Belongs to the ABC transporter superfamily
A3862_RS28175	COG4608	Belongs to the ABC transporter superfamily
A3862_RS28180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS28245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A3862_RS28270	COG1620	l-lactate permease
A3862_RS28275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3862_RS28280	COG1702	phosphate starvation-inducible protein PhoH
A3862_RS28285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A3862_RS28290	COG1253	flavin adenine dinucleotide binding
A3862_RS28295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A3862_RS28300	COG2807	transmembrane transport
A3862_RS28310	COG0753	catalase activity
A3862_RS28320	COG0165	Argininosuccinate lyase
A3862_RS28325	COG3180	Ammonia monooxygenase
A3862_RS28330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A3862_RS28335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A3862_RS28340	COG1285	pathogenesis
A3862_RS28350	COG2814	Major facilitator Superfamily
A3862_RS28360	COG0784	Response regulator, receiver
A3862_RS28365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3862_RS28375	COG0596	Alpha beta hydrolase
A3862_RS28390	COG1028	Short-chain dehydrogenase reductase Sdr
A3862_RS28410	COG4214	carbohydrate transport
A3862_RS28420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3862_RS28435	COG0137	argininosuccinate synthase activity
A3862_RS28450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A3862_RS28455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A3862_RS28460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3862_RS28465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A3862_RS28470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A3862_RS28485	COG0494	nUDIX hydrolase
A3862_RS28505	COG1643	Atp-dependent helicase
A3862_RS28540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3862_RS28550	COG0024	Methionine aminopeptidase
A3862_RS28555	COG2003	Belongs to the UPF0758 family
A3862_RS28560	COG2308	Evidence 4 Homologs of previously reported genes of
A3862_RS28580	COG0352	thiamine-phosphate diphosphorylase activity
A3862_RS28585	COG2022	thiamine diphosphate biosynthetic process
A3862_RS28595	COG2022	thiamine diphosphate biosynthetic process
A3862_RS28595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3862_RS28615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3862_RS28620	COG0358	DNA primase activity
A3862_RS28630	COG0505	Belongs to the CarA family
A3862_RS28640	COG3794	PFAM blue (type 1) copper domain protein
A3862_RS28645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A3862_RS28650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3862_RS28670	COG0492	ferredoxin-NADP+ reductase activity
A3862_RS28675	COG1309	transcriptional regulator
A3862_RS28680	COG0300	oxidoreductase activity
A3862_RS28685	COG0583	DNA-binding transcription factor activity
A3862_RS28695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS28700	COG0318	PFAM AMP-dependent synthetase and ligase
A3862_RS28710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A3862_RS28725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A3862_RS28730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A3862_RS28735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3862_RS28745	COG0784	Response regulator, receiver
A3862_RS28745	COG4191	Histidine kinase
A3862_RS28765	COG0243	molybdopterin cofactor binding
A3862_RS28795	COG0657	acetylesterase activity
A3862_RS28800	COG1201	RNA secondary structure unwinding
A3862_RS28820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A3862_RS28825	COG0459	protein refolding
A3862_RS28835	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
A3862_RS28845	COG0189	ligase activity
A3862_RS28860	COG0702	epimerase
A3862_RS28870	COG1029	Formylmethanofuran dehydrogenase, subunit B
A3862_RS28875	COG1229	Formylmethanofuran dehydrogenase subunit A
A3862_RS28880	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
A3862_RS28885	COG2218	PFAM glutamate synthase alpha subunit domain protein
A3862_RS28895	COG2205	protein histidine kinase activity
A3862_RS28900	COG0745	RESPONSE REGULATOR receiver
A3862_RS28910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3862_RS28915	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A3862_RS28920	COG0535	radical SAM domain protein
A3862_RS28935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A3862_RS28940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A3862_RS28945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A3862_RS28970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A3862_RS29005	COG0110	maltose O-acetyltransferase activity
A3862_RS29010	COG0280	phosphate acetyltransferase
A3862_RS29010	COG0281	malic enzyme
A3862_RS29020	COG0840	transmembrane signaling receptor activity
A3862_RS29025	COG0248	Ppx GppA phosphatase
A3862_RS29030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A3862_RS29040	COG0628	permease
A3862_RS29045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3862_RS29050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A3862_RS29060	COG0105	UTP biosynthetic process
A3862_RS29070	COG0625	glutathione transferase activity
A3862_RS29090	COG1566	PFAM secretion protein HlyD family protein
A3862_RS29100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3862_RS29115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3862_RS29125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A3862_RS29130	COG0758	DNA mediated transformation
A3862_RS29135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A3862_RS29145	COG0107	imidazoleglycerol-phosphate synthase activity
A3862_RS29150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A3862_RS29155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3862_RS29165	COG0131	Imidazoleglycerol-phosphate dehydratase
A3862_RS29170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3862_RS29180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A3862_RS29180	COG2857	Cytochrome c1
A3862_RS29185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A3862_RS29185	COG2857	Cytochrome c1
A3862_RS29190	COG0723	plastoquinol--plastocyanin reductase activity
A3862_RS29195	COG1132	(ABC) transporter
A3862_RS29235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A3862_RS29240	COG1720	tRNA m6t6A37 methyltransferase activity
A3862_RS29250	COG0519	Catalyzes the synthesis of GMP from XMP
A3862_RS29250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3862_RS29275	COG0656	L-ascorbic acid biosynthetic process
A3862_RS29305	COG0477	Major facilitator Superfamily
A3862_RS29310	COG1454	alcohol dehydrogenase
A3862_RS29315	COG1012	belongs to the aldehyde dehydrogenase family
A3862_RS29320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3862_RS29325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3862_RS29330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3862_RS29340	COG4585	Histidine kinase
A3862_RS29350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3862_RS29360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A3862_RS29365	COG0488	(ABC) transporter
A3862_RS29385	COG1609	Transcriptional regulator
A3862_RS29410	COG0477	Major facilitator Superfamily
A3862_RS29460	COG0438	transferase activity, transferring glycosyl groups
A3862_RS29525	COG0300	oxidoreductase activity
A3862_RS29560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3862_RS29605	COG0625	glutathione transferase activity
A3862_RS29610	COG0583	DNA-binding transcription factor activity
A3862_RS29620	COG0596	Alpha beta hydrolase
A3862_RS29625	COG0583	DNA-binding transcription factor activity
A3862_RS29630	COG2267	carboxylic ester hydrolase activity
A3862_RS29705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3862_RS29725	COG0596	Alpha beta hydrolase
A3862_RS29770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3862_RS29795	COG0747	negative chemotaxis
A3862_RS29800	COG0402	S-adenosylhomocysteine deaminase activity
A3862_RS29810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3862_RS29830	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3862_RS29835	COG1129	ABC transporter
A3862_RS29870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3862_RS29880	COG0583	DNA-binding transcription factor activity
A3862_RS29885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3862_RS29895	COG4166	transmembrane transport
A3862_RS29900	COG0601	transmembrane transport
A3862_RS29905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3862_RS29915	COG0154	amidase activity
A3862_RS29965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3862_RS30055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3862_RS30060	COG0596	Alpha beta hydrolase
A3862_RS30175	COG2826	transposase and inactivated derivatives, IS30 family
A3862_RS30185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3862_RS30275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3862_RS30280	COG0720	synthase
A3862_RS30285	COG0602	queuosine metabolic process
A3862_RS30310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3862_RS30350	COG4423	Transcription factor
A3862_RS30360	COG5489	Protein of unknown function (DUF736)
A3862_RS30415	COG1475	DNA binding
A3862_RS30475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3862_RS30495	COG2184	nucleotidyltransferase activity
A3862_RS30515	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A3862_RS30635	COG1192	Involved in chromosome partitioning
A3862_RS30640	COG1475	DNA binding
A3862_RS30645	COG0640	Transcriptional regulator
A3862_RS30650	COG1132	(ABC) transporter
A3862_RS30675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A3862_RS30680	COG3781	membrane
A3862_RS30690	COG1294	oxidase, subunit
A3862_RS30695	COG1271	oxidase subunit
A3862_RS30705	COG0583	DNA-binding transcription factor activity
A3862_RS30730	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A3862_RS30735	COG1252	NADH dehydrogenase
A3862_RS30745	COG0556	nucleotide-excision repair
A3862_RS30755	COG2837	iron assimilation
A3862_RS30775	COG3609	addiction module antidote protein, CC2985 family
A3862_RS30780	COG3505	Type IV secretory pathway VirD4
A3862_RS30785	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A3862_RS30800	COG3736	Type IV secretory pathway, component VirB8
A3862_RS30815	COG0693	protein deglycase activity
A3862_RS30845	COG1902	pentaerythritol trinitrate reductase activity
A3862_RS30850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3862_RS30855	COG0640	Transcriptional regulator
A3862_RS30935	COG0659	secondary active sulfate transmembrane transporter activity