locus-tag	class	description
MCA_RS00005	COG0445	tRNA wobble uridine modification
MCA_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
MCA_RS00015	COG1192	Involved in chromosome partitioning
MCA_RS00020	COG1475	DNA binding
MCA_RS00030	COG0356	it plays a direct role in the translocation of protons across the membrane
MCA_RS00040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCA_RS00045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MCA_RS00050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MCA_RS00055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MCA_RS00060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCA_RS00065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MCA_RS00070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCA_RS00075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCA_RS00080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCA_RS00080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCA_RS00090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MCA_RS00100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MCA_RS00105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MCA_RS00110	COG0617	tRNA 3'-terminal CCA addition
MCA_RS00115	COG0730	response to heat
MCA_RS00125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MCA_RS00135	COG3328	transposase activity
MCA_RS00145	COG2852	Protein conserved in bacteria
MCA_RS00155	COG5433	transposase activity
MCA_RS00165	COG3645	SOS response
MCA_RS00190	COG0800	Aldolase
MCA_RS00195	COG1461	Dihydroxyacetone kinase
MCA_RS00200	COG2376	Dihydroxyacetone kinase
MCA_RS00210	COG0678	peroxiredoxin activity
MCA_RS00215	COG0698	ribose 5-phosphate isomerase
MCA_RS00225	COG1515	deoxyribonuclease V activity
MCA_RS00230	COG3956	TIGRFAM MazG family protein
MCA_RS00235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCA_RS00240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MCA_RS00245	COG5297	Belongs to the glycosyl hydrolase family 6
MCA_RS00245	COG4733	cellulase activity
MCA_RS00255	COG0509	glycine decarboxylation via glycine cleavage system
MCA_RS00260	COG0489	protein tyrosine kinase activity
MCA_RS00265	COG0717	Belongs to the dCTP deaminase family
MCA_RS00270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCA_RS00275	COG0586	Pfam SNARE associated Golgi protein
MCA_RS00280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MCA_RS00305	COG3409	Peptidoglycan-binding domain 1 protein
MCA_RS00305	COG3267	Type II secretory pathway component ExeA
MCA_RS00310	COG0109	protoheme IX farnesyltransferase activity
MCA_RS00315	COG0612	Peptidase, M16
MCA_RS00325	COG0742	ribosomal rna small subunit methyltransferase
MCA_RS00330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MCA_RS00335	COG0058	SHG alpha-glucan phosphorylase activity
MCA_RS00340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MCA_RS00355	COG2078	PFAM AMMECR1 domain protein
MCA_RS00360	COG1355	regulation of microtubule-based process
MCA_RS00405	COG1047	Peptidyl-prolyl cis-trans
MCA_RS00410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCA_RS00460	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
MCA_RS00475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MCA_RS00485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCA_RS00490	COG0154	amidase activity
MCA_RS00495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCA_RS00500	COG1077	Cell shape determining protein MreB Mrl
MCA_RS00505	COG1792	Involved in formation and maintenance of cell shape
MCA_RS00515	COG0768	penicillin binding
MCA_RS00520	COG0772	Belongs to the SEDS family
MCA_RS00525	COG1686	Belongs to the peptidase S11 family
MCA_RS00530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MCA_RS00535	COG2921	Belongs to the UPF0250 family
MCA_RS00540	COG2239	Acts as a magnesium transporter
MCA_RS00545	COG0321	lipoyl(octanoyl) transferase activity
MCA_RS00550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MCA_RS00560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MCA_RS00570	COG3259	Nickel-dependent hydrogenase
MCA_RS00575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCA_RS00580	COG3339	Conserved Protein
MCA_RS00590	COG1442	glycosyl transferase family 8
MCA_RS00590	COG1216	Glycosyl transferase, family 2
MCA_RS00595	COG1214	PFAM Peptidase M22, glycoprotease
MCA_RS00595	COG0456	acetyltransferase
MCA_RS00600	COG0628	permease
MCA_RS00635	COG0488	(ABC) transporter
MCA_RS00645	COG1477	protein flavinylation
MCA_RS00665	COG0552	protein localization to endoplasmic reticulum
MCA_RS00670	COG2884	Cell division ATP-binding protein ftsE
MCA_RS00675	COG2177	Part of the ABC transporter FtsEX involved in
MCA_RS00685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MCA_RS00690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MCA_RS00695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MCA_RS00705	COG1881	PFAM PEBP family protein
MCA_RS00715	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MCA_RS00735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MCA_RS00770	COG0438	transferase activity, transferring glycosyl groups
MCA_RS00795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCA_RS00800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MCA_RS00810	COG1773	rubredoxin
MCA_RS00845	COG1132	(ABC) transporter
MCA_RS00850	COG0390	transport system, permease component
MCA_RS00870	COG1127	ABC transporter
MCA_RS00875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MCA_RS00910	COG0277	FAD linked oxidase domain protein
MCA_RS00915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MCA_RS00920	COG0792	nuclease activity
MCA_RS00925	COG3107	peptidoglycan biosynthetic process
MCA_RS00980	COG1408	metallophosphoesterase
MCA_RS00995	COG2915	High frequency lysogenization protein hflD homolog
MCA_RS01010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MCA_RS01030	COG5554	nitrogen fixation
MCA_RS01050	COG5554	nitrogen fixation
MCA_RS01060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCA_RS01130	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MCA_RS01140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCA_RS01150	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCA_RS01155	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCA_RS01170	COG5420	small protein containing a coiled-coil domain
MCA_RS01175	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
MCA_RS01190	COG2967	ApaG domain
MCA_RS01195	COG0740	serine-type endopeptidase activity
MCA_RS01200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCA_RS01215	COG1104	cysteine desulfurase activity
MCA_RS01220	COG0822	iron-sulfur transferase activity
MCA_RS01225	COG0316	Belongs to the HesB IscA family
MCA_RS01235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MCA_RS01240	COG0443	Heat shock 70 kDa protein
MCA_RS01260	COG3411	Ferredoxin
MCA_RS01275	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MCA_RS01280	COG5007	Belongs to the BolA IbaG family
MCA_RS01300	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCA_RS01320	COG0004	ammonium transporteR
MCA_RS01340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MCA_RS01415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MCA_RS01425	COG0519	Catalyzes the synthesis of GMP from XMP
MCA_RS01425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCA_RS01480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MCA_RS01540	COG0330	HflC and HflK could
MCA_RS01545	COG0330	HflC and HflK could
MCA_RS01555	COG1309	transcriptional regulator
MCA_RS01560	COG3391	amine dehydrogenase activity
MCA_RS01565	COG1858	cytochrome C peroxidase
MCA_RS01575	COG2814	Major facilitator Superfamily
MCA_RS01580	COG0708	Exodeoxyribonuclease III
MCA_RS01585	COG0254	rRNA binding
MCA_RS01625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MCA_RS01630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MCA_RS01635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCA_RS01640	COG0494	nUDIX hydrolase
MCA_RS01650	COG0543	2 iron, 2 sulfur cluster binding
MCA_RS01650	COG0493	'glutamate synthase
MCA_RS01680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MCA_RS01685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCA_RS01690	COG0531	amino acid
MCA_RS01700	COG1858	cytochrome C peroxidase
MCA_RS01715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCA_RS01720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCA_RS01725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MCA_RS01745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MCA_RS01750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MCA_RS01760	COG0730	response to heat
MCA_RS01765	COG0519	Catalyzes the synthesis of GMP from XMP
MCA_RS01770	COG0613	PHP domain protein
MCA_RS01780	COG0151	Belongs to the GarS family
MCA_RS01790	COG2995	paraquat-inducible protein a
MCA_RS01795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MCA_RS01795	COG3008	intermembrane lipid transfer
MCA_RS01840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MCA_RS01845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MCA_RS01850	COG0463	Glycosyl transferase, family 2
MCA_RS01860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MCA_RS01865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MCA_RS01870	COG0424	maF-like protein
MCA_RS01890	COG0312	modulator of DNA gyrase
MCA_RS01895	COG0312	modulator of DNA gyrase
MCA_RS01905	COG1546	Belongs to the CinA family
MCA_RS01910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MCA_RS01915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MCA_RS01920	COG2137	regulation of response to DNA damage stimulus
MCA_RS01925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCA_RS01935	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MCA_RS01945	COG0228	four-way junction DNA binding
MCA_RS01950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MCA_RS01955	COG0336	Belongs to the RNA methyltransferase TrmD family
MCA_RS01960	COG0335	large ribosomal subunit rRNA binding
MCA_RS01970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCA_RS01975	COG0673	inositol 2-dehydrogenase activity
MCA_RS01985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCA_RS01990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCA_RS01995	COG1451	nucleotide metabolic process
MCA_RS02045	COG1376	ErfK ybiS ycfS ynhG family protein
MCA_RS02045	COG1388	LysM domain
MCA_RS02050	COG1678	Uncharacterized ACR, COG1678
MCA_RS02065	COG3088	subunit of a heme lyase
MCA_RS02070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCA_RS02075	COG1138	Cytochrome C-type biogenesis protein
MCA_RS02080	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MCA_RS02135	COG0348	domain, Protein
MCA_RS02140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MCA_RS02165	COG0811	peptide transport
MCA_RS02170	COG0811	peptide transport
MCA_RS02175	COG0848	biopolymer transport protein
MCA_RS02225	COG4085	toxin activity
MCA_RS02225	COG1525	nuclease
MCA_RS02225	COG0737	Belongs to the 5'-nucleotidase family
MCA_RS02230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MCA_RS02235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MCA_RS02240	COG2217	Heavy metal translocating P-type atpase
MCA_RS02250	COG2894	cell division
MCA_RS02295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MCA_RS02310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MCA_RS02315	COG0406	alpha-ribazole phosphatase activity
MCA_RS02320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MCA_RS02335	COG0714	Associated with various cellular activities
MCA_RS02350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MCA_RS02355	COG0367	asparagine synthase
MCA_RS02370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MCA_RS02375	COG1984	allophanate hydrolase subunit 2
MCA_RS02380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MCA_RS02405	COG4989	oxidoreductase activity
MCA_RS02425	COG0004	ammonium transporteR
MCA_RS02435	COG1090	epimerase
MCA_RS02440	COG2154	pterin-4-alpha-carbinolamine dehydratase
MCA_RS02490	COG3404	Formiminotransferase-cyclodeaminase
MCA_RS02495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCA_RS02500	COG0215	cysteine-tRNA ligase activity
MCA_RS02505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCA_RS02510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCA_RS02515	COG3002	Belongs to the UPF0753 family
MCA_RS02525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCA_RS02535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MCA_RS02540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MCA_RS02545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCA_RS02550	COG0494	nUDIX hydrolase
MCA_RS02560	COG2983	Belongs to the UPF0260 family
MCA_RS02600	COG0544	peptidyl-prolyl cis-trans isomerase activity
MCA_RS02605	COG0740	serine-type endopeptidase activity
MCA_RS02610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCA_RS02615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MCA_RS02635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCA_RS02655	COG1162	GTPase activity
MCA_RS02660	COG0501	Belongs to the peptidase M48B family
MCA_RS02665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MCA_RS02680	COG0367	asparagine synthase
MCA_RS02690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCA_RS02695	COG0387	Pfam Sodium calcium exchanger
MCA_RS02715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCA_RS02745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCA_RS02750	COG0842	Transport permease protein
MCA_RS02750	COG1129	ABC transporter
MCA_RS02760	COG0842	Transport permease protein
MCA_RS02775	COG0432	Pfam Uncharacterised protein family UPF0047
MCA_RS02785	COG0837	glucose binding
MCA_RS02795	COG0686	Belongs to the AlaDH PNT family
MCA_RS02805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MCA_RS02810	COG0024	Methionine aminopeptidase
MCA_RS02815	COG0052	Belongs to the universal ribosomal protein uS2 family
MCA_RS02820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MCA_RS02825	COG0528	UMP kinase activity
MCA_RS02830	COG0233	cytoplasmic translational termination
MCA_RS02835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCA_RS02840	COG0575	Belongs to the CDS family
MCA_RS02845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MCA_RS02855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MCA_RS02860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MCA_RS02890	COG0517	IMP dehydrogenase activity
MCA_RS02895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MCA_RS02900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MCA_RS02920	COG3707	response regulator
MCA_RS02925	COG1116	anion transmembrane transporter activity
MCA_RS02925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCA_RS02930	COG0243	molybdopterin cofactor binding
MCA_RS02940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCA_RS02945	COG0515	serine threonine protein kinase
MCA_RS02945	COG2815	serine threonine protein kinase
MCA_RS02950	COG2223	nitrite transmembrane transporter activity
MCA_RS02960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MCA_RS02970	COG0436	Aminotransferase
MCA_RS02975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MCA_RS02985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MCA_RS02990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCA_RS02995	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MCA_RS03000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCA_RS03015	COG0033	Phosphoglucomutase
MCA_RS03025	COG0488	(ABC) transporter
MCA_RS03030	COG0039	L-malate dehydrogenase activity
MCA_RS03040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCA_RS03045	COG0438	transferase activity, transferring glycosyl groups
MCA_RS03050	COG1696	Membrane protein involved in D-alanine export
MCA_RS03080	COG1216	Glycosyl transferase, family 2
MCA_RS03080	COG0438	transferase activity, transferring glycosyl groups
MCA_RS03085	COG1216	Glycosyl transferase, family 2
MCA_RS03090	COG1216	Glycosyl transferase, family 2
MCA_RS03120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MCA_RS03125	COG0351	phosphomethylpyrimidine kinase
MCA_RS03135	COG0811	peptide transport
MCA_RS03140	COG0848	biopolymer transport protein
MCA_RS03145	COG1663	tetraacyldisaccharide 4'-kinase activity
MCA_RS03150	COG2835	tetraacyldisaccharide 4'-kinase activity
MCA_RS03155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MCA_RS03160	COG1238	metal cluster binding
MCA_RS03175	COG1902	pentaerythritol trinitrate reductase activity
MCA_RS03205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCA_RS03220	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MCA_RS03225	COG1518	maintenance of DNA repeat elements
MCA_RS03260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCA_RS03265	COG1940	carbohydrate kinase activity
MCA_RS03275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MCA_RS03280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCA_RS03285	COG3830	Belongs to the UPF0237 family
MCA_RS03290	COG1968	undecaprenyl-diphosphatase activity
MCA_RS03295	COG0586	Pfam SNARE associated Golgi protein
MCA_RS03315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCA_RS03330	COG0149	triose-phosphate isomerase activity
MCA_RS03335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MCA_RS03345	COG0582	viral genome integration into host DNA
MCA_RS03360	COG0343	queuine tRNA-ribosyltransferase activity
MCA_RS03365	COG1862	Preprotein translocase
MCA_RS03370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCA_RS03375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCA_RS03395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MCA_RS03400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MCA_RS03405	COG1074	ATP-dependent DNA helicase activity
MCA_RS03410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCA_RS03420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCA_RS03425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MCA_RS03430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MCA_RS03435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MCA_RS03440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MCA_RS03445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCA_RS03445	COG0072	phenylalanine-tRNA ligase activity
MCA_RS03450	COG0776	regulation of translation
MCA_RS03455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MCA_RS03465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MCA_RS03480	COG2217	Heavy metal translocating P-type atpase
MCA_RS03485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MCA_RS03490	COG0459	protein refolding
MCA_RS03510	COG1295	ribonuclease BN
MCA_RS03515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MCA_RS03515	COG0116	Belongs to the methyltransferase superfamily
MCA_RS03520	COG1254	Belongs to the acylphosphatase family
MCA_RS03530	COG2703	oxygen carrier activity
MCA_RS03545	COG0531	amino acid
MCA_RS03550	COG0328	RNA-DNA hybrid ribonuclease activity
MCA_RS03555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MCA_RS03595	COG2826	transposase and inactivated derivatives, IS30 family
MCA_RS03630	COG1032	radical SAM domain protein
MCA_RS03635	COG1660	Displays ATPase and GTPase activities
MCA_RS03645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MCA_RS03650	COG1137	ATPase activity
MCA_RS03665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MCA_RS03675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MCA_RS03680	COG0316	Belongs to the HesB IscA family
MCA_RS03685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MCA_RS03730	COG0312	modulator of DNA gyrase
MCA_RS03760	COG0633	Ferredoxin
MCA_RS03800	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCA_RS03800	COG1013	pyruvate-flavodoxin oxidoreductase activity
MCA_RS03800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MCA_RS03800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MCA_RS03825	COG0308	aminopeptidase N
MCA_RS03840	COG2197	response regulator
MCA_RS03850	COG4993	Dehydrogenase
MCA_RS03855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCA_RS03860	COG2010	Cytochrome c
MCA_RS03870	COG0714	Associated with various cellular activities
MCA_RS03910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MCA_RS03925	COG0500	methyltransferase
MCA_RS03935	COG3108	Peptidase M15
MCA_RS03940	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
MCA_RS03945	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MCA_RS03950	COG0235	Class ii aldolase
MCA_RS03980	COG2217	Heavy metal translocating P-type atpase
MCA_RS04015	COG1657	PFAM Prenyltransferase squalene oxidase
MCA_RS04025	COG0535	radical SAM domain protein
MCA_RS04030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCA_RS04035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCA_RS04040	COG0142	geranyltranstransferase activity
MCA_RS04045	COG1722	exodeoxyribonuclease VII activity
MCA_RS04060	COG2801	Transposase and inactivated derivatives
MCA_RS04085	COG0457	Tetratricopeptide repeat
MCA_RS04085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MCA_RS04095	COG2198	Histidine kinase
MCA_RS04095	COG0643	Histidine kinase
MCA_RS04100	COG2201	protein-glutamate methylesterase activity
MCA_RS04105	COG2208	phosphoserine phosphatase activity
MCA_RS04115	COG3177	Filamentation induced by cAMP protein fic
MCA_RS04120	COG0732	type I restriction modification DNA specificity domain
MCA_RS04125	COG1943	Transposase
MCA_RS04130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MCA_RS04140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCA_RS04145	COG0386	Belongs to the glutathione peroxidase family
MCA_RS04155	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MCA_RS04160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCA_RS04180	COG0326	Molecular chaperone. Has ATPase activity
MCA_RS04190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCA_RS04195	COG3058	Necessary for formate dehydrogenase activity
MCA_RS04200	COG1067	ATP-dependent peptidase activity
MCA_RS04205	COG2974	May be involved in recombination
MCA_RS04210	COG1376	ErfK ybiS ycfS ynhG family protein
MCA_RS04215	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MCA_RS04220	COG1194	a g-specific adenine glycosylase
MCA_RS04225	COG0019	diaminopimelate decarboxylase activity
MCA_RS04230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MCA_RS04240	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MCA_RS04255	COG3028	Belongs to the UPF0307 family
MCA_RS04270	COG2840	Smr protein MutS2
MCA_RS04285	COG1177	transmembrane transport
MCA_RS04295	COG3842	ATPase activity
MCA_RS04330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MCA_RS04335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCA_RS04340	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MCA_RS04360	COG3039	Transposase
MCA_RS04405	COG0175	sulfate reduction
MCA_RS04415	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MCA_RS04425	COG5583	Uncharacterized small protein (DUF2292)
MCA_RS04430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCA_RS04440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MCA_RS04445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCA_RS04465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCA_RS04490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCA_RS04505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCA_RS04530	COG2226	methyltransferase
MCA_RS04540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCA_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
MCA_RS04560	COG0475	glutathione-regulated potassium exporter activity
MCA_RS04570	COG1518	maintenance of DNA repeat elements
MCA_RS04585	COG1857	crispr-associated protein
MCA_RS04600	COG1203	CRISPR-associated helicase, Cas3
MCA_RS04630	COG0366	Alpha amylase catalytic
MCA_RS04665	COG0154	amidase activity
MCA_RS04685	COG4133	protoheme IX ABC transporter activity
MCA_RS04695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MCA_RS04710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCA_RS04735	COG1132	(ABC) transporter
MCA_RS04745	COG0045	succinate-CoA ligase (ADP-forming) activity
MCA_RS04750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MCA_RS04760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCA_RS04770	COG0564	pseudouridine synthase activity
MCA_RS04785	COG3158	transport of potassium into the cell
MCA_RS04800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCA_RS04845	COG0822	iron-sulfur transferase activity
MCA_RS04855	COG0719	Fe-S assembly protein
MCA_RS04860	COG0396	ATPase activity
MCA_RS04865	COG0719	Fe-S assembly protein
MCA_RS04870	COG1959	2 iron, 2 sulfur cluster binding
MCA_RS04890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MCA_RS04890	COG4106	trans-aconitate 2-methyltransferase activity
MCA_RS04910	COG0625	glutathione transferase activity
MCA_RS04920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MCA_RS04925	COG0306	phosphate transporter
MCA_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
MCA_RS04945	COG0724	RNA recognition motif
MCA_RS04950	COG0513	Belongs to the DEAD box helicase family
MCA_RS04980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCA_RS05000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MCA_RS05015	COG0450	alkyl hydroperoxide reductase
MCA_RS05050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MCA_RS05060	COG2183	response to ionizing radiation
MCA_RS05065	COG2267	carboxylic ester hydrolase activity
MCA_RS05080	COG0210	DNA helicase
MCA_RS05090	COG3030	protein affecting phage T7 exclusion by the F plasmid
MCA_RS05095	COG1324	tolerance protein
MCA_RS05100	COG4232	protein-disulfide reductase activity
MCA_RS05105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCA_RS05110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MCA_RS05115	COG0511	ligase activity, forming carbon-carbon bonds
MCA_RS05120	COG0439	Biotin carboxylase
MCA_RS05125	COG2264	protein methyltransferase activity
MCA_RS05140	COG2890	protein-(glutamine-N5) methyltransferase activity
MCA_RS05145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MCA_RS05150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCA_RS05160	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MCA_RS05165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MCA_RS05175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MCA_RS05180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MCA_RS05185	COG0193	aminoacyl-tRNA hydrolase activity
MCA_RS05205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCA_RS05225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MCA_RS05230	COG0081	regulation of translation
MCA_RS05235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MCA_RS05240	COG0222	ribosome binding
MCA_RS05245	COG0085	RNA polymerase activity
MCA_RS05250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCA_RS05275	COG0573	inorganic phosphate transmembrane transporter activity
MCA_RS05285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MCA_RS05295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MCA_RS05300	COG2022	thiamine diphosphate biosynthetic process
MCA_RS05300	COG2104	thiamine diphosphate biosynthetic process
MCA_RS05375	COG1546	Belongs to the CinA family
MCA_RS05375	COG1058	Belongs to the CinA family
MCA_RS05385	COG0284	orotidine-5'-phosphate decarboxylase activity
MCA_RS05395	COG2204	response regulator
MCA_RS05400	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MCA_RS05410	COG0137	argininosuccinate synthase activity
MCA_RS05415	COG2132	Multicopper oxidase
MCA_RS05420	COG2204	response regulator
MCA_RS05425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCA_RS05445	COG1294	oxidase, subunit
MCA_RS05465	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MCA_RS05470	COG0730	response to heat
MCA_RS05480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCA_RS05490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MCA_RS05495	COG1459	type II secretion system
MCA_RS05510	COG2165	general secretion pathway protein
MCA_RS05520	COG3156	type II secretion system protein K
MCA_RS05540	COG1450	Type ii and iii secretion system protein
MCA_RS05550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MCA_RS05555	COG0156	8-amino-7-oxononanoate synthase activity
MCA_RS05560	COG0596	Alpha beta hydrolase
MCA_RS05565	COG2226	methyltransferase
MCA_RS05580	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MCA_RS05585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MCA_RS05595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCA_RS05610	COG3260	NADH ubiquinone oxidoreductase 20
MCA_RS05615	COG0649	NAD binding
MCA_RS05620	COG0651	ATP synthesis coupled electron transport
MCA_RS05625	COG4237	Hydrogenase 4 membrane
MCA_RS05635	COG0651	ATP synthesis coupled electron transport
MCA_RS05655	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MCA_RS05660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCA_RS05710	COG1216	Glycosyl transferase, family 2
MCA_RS05720	COG0297	glycogen (starch) synthase activity
MCA_RS05735	COG2192	nodulation
MCA_RS05745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCA_RS05785	COG1596	polysaccharide export
MCA_RS05800	COG0489	protein tyrosine kinase activity
MCA_RS05805	COG4464	protein tyrosine phosphatase activity
MCA_RS05815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MCA_RS05820	COG4208	sulfate ABC transporter
MCA_RS05825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MCA_RS05850	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MCA_RS05865	COG1999	signal sequence binding
MCA_RS05885	COG3350	monooxygenase activity
MCA_RS05915	COG0543	2 iron, 2 sulfur cluster binding
MCA_RS05915	COG0633	Ferredoxin
MCA_RS05925	COG0459	protein refolding
MCA_RS05935	COG2205	protein histidine kinase activity
MCA_RS05935	COG0784	Response regulator, receiver
MCA_RS05935	COG5002	protein histidine kinase activity
MCA_RS05940	COG2204	response regulator
MCA_RS05950	COG3123	guanosine phosphorylase activity
MCA_RS05955	COG2864	formate dehydrogenase
MCA_RS05960	COG0437	4 iron, 4 sulfur cluster binding
MCA_RS05965	COG0243	molybdopterin cofactor binding
MCA_RS05965	COG3383	formate dehydrogenase (NAD+) activity
MCA_RS05970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCA_RS05975	COG0430	RNA-3'-phosphate cyclase activity
MCA_RS05980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MCA_RS05980	COG1796	DNA polymerase
MCA_RS05985	COG1132	(ABC) transporter
MCA_RS06010	COG3328	transposase activity
MCA_RS06015	COG0217	transcriptional regulatory protein
MCA_RS06020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MCA_RS06025	COG0632	four-way junction helicase activity
MCA_RS06030	COG2255	four-way junction helicase activity
MCA_RS06040	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MCA_RS06060	COG0823	Involved in the tonB-independent uptake of proteins
MCA_RS06065	COG2885	chlorophyll binding
MCA_RS06075	COG0602	queuosine metabolic process
MCA_RS06080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MCA_RS06085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCA_RS06125	COG0167	dihydroorotate dehydrogenase activity
MCA_RS06130	COG1891	lyase activity
MCA_RS06150	COG0166	Belongs to the GPI family
MCA_RS06155	COG0165	Argininosuccinate lyase
MCA_RS06165	COG1253	flavin adenine dinucleotide binding
MCA_RS06170	COG0205	6-phosphofructokinase activity
MCA_RS06175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MCA_RS06185	COG1773	rubredoxin
MCA_RS06200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCA_RS06205	COG1981	membrane
MCA_RS06245	COG0601	transmembrane transport
MCA_RS06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCA_RS06255	COG0560	Phosphoserine phosphatase
MCA_RS06260	COG4172	Belongs to the ABC transporter superfamily
MCA_RS06270	COG2151	metal-sulfur cluster biosynthetic enzyme
MCA_RS06280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCA_RS06285	COG0402	S-adenosylhomocysteine deaminase activity
MCA_RS06300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MCA_RS06305	COG1538	Outer membrane efflux protein
MCA_RS06320	COG1131	(ABC) transporter
MCA_RS06325	COG1129	ABC transporter
MCA_RS06325	COG0842	Transport permease protein
MCA_RS06385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MCA_RS06395	COG0860	N-Acetylmuramoyl-L-alanine amidase
MCA_RS06415	COG0802	atpase or kinase
MCA_RS06420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MCA_RS06420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MCA_RS06445	COG0443	Heat shock 70 kDa protein
MCA_RS06455	COG0670	Belongs to the BI1 family
MCA_RS06460	COG1185	polyribonucleotide nucleotidyltransferase activity
MCA_RS06465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MCA_RS06470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MCA_RS06480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MCA_RS06485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MCA_RS06490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCA_RS06495	COG0195	Participates in both transcription termination and antitermination
MCA_RS06500	COG0779	Required for maturation of 30S ribosomal subunits
MCA_RS06505	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCA_RS06510	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MCA_RS06515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MCA_RS06520	COG1509	lysine 2,3-aminomutase activity
MCA_RS06535	COG0537	adenosine 5'-monophosphoramidase activity
MCA_RS06540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MCA_RS06545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MCA_RS06550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MCA_RS06555	COG4783	chaperone-mediated protein folding
MCA_RS06560	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MCA_RS06570	COG2168	tRNA wobble position uridine thiolation
MCA_RS06575	COG2920	part of a sulfur-relay system
MCA_RS06580	COG3161	chorismate lyase activity
MCA_RS06585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MCA_RS06590	COG4137	Cytochrome C assembly protein
MCA_RS06595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCA_RS06625	COG0798	PFAM Bile acid sodium symporter
MCA_RS06630	COG1007	ATP synthesis coupled electron transport
MCA_RS06645	COG0713	ATP synthesis coupled electron transport
MCA_RS06655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCA_RS06660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MCA_RS06675	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MCA_RS06680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCA_RS06680	COG0649	NAD binding
MCA_RS06685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCA_RS06690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCA_RS06700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCA_RS06715	COG1426	Protein conserved in bacteria
MCA_RS06735	COG0488	(ABC) transporter
MCA_RS06745	COG2193	ferroxidase activity
MCA_RS06755	COG0242	peptide deformylase activity
MCA_RS06760	COG0778	Nitroreductase
MCA_RS06790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MCA_RS06805	COG0501	Belongs to the peptidase M48B family
MCA_RS06825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MCA_RS06840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MCA_RS06845	COG3383	formate dehydrogenase (NAD+) activity
MCA_RS06865	COG1160	GTP binding
MCA_RS06885	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MCA_RS06890	COG4181	ATPase activity
MCA_RS06905	COG0741	lytic transglycosylase activity
MCA_RS06905	COG1388	LysM domain
MCA_RS06920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MCA_RS06930	COG0237	dephospho-CoA kinase activity
MCA_RS06935	COG0688	phosphatidylethanolamine metabolic process
MCA_RS06940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MCA_RS06945	COG0776	regulation of translation
MCA_RS06955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MCA_RS06960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MCA_RS06965	COG0287	Prephenate dehydrogenase
MCA_RS06970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCA_RS06985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MCA_RS07040	COG1366	Belongs to the anti-sigma-factor antagonist family
MCA_RS07045	COG0438	transferase activity, transferring glycosyl groups
MCA_RS07065	COG1045	serine acetyltransferase
MCA_RS07085	COG2208	phosphoserine phosphatase activity
MCA_RS07095	COG2226	methyltransferase
MCA_RS07100	COG0288	reversible hydration of carbon dioxide
MCA_RS07105	COG0659	secondary active sulfate transmembrane transporter activity
MCA_RS07115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MCA_RS07130	COG0535	radical SAM domain protein
MCA_RS07140	COG1466	dna polymerase III delta subunit
MCA_RS07150	COG0495	leucyl-tRNA aminoacylation
MCA_RS07160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MCA_RS07165	COG4535	Mg2 and Co2 transporter CorC
MCA_RS07170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MCA_RS07175	COG1702	phosphate starvation-inducible protein PhoH
MCA_RS07180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCA_RS07190	COG1381	Involved in DNA repair and RecF pathway recombination
MCA_RS07195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MCA_RS07200	COG0571	ribonuclease III activity
MCA_RS07210	COG0681	Belongs to the peptidase S26 family
MCA_RS07215	COG0481	GTPase activity
MCA_RS07220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCA_RS07255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MCA_RS07260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MCA_RS07265	COG0297	glycogen (starch) synthase activity
MCA_RS07270	COG0494	nUDIX hydrolase
MCA_RS07280	COG0564	pseudouridine synthase activity
MCA_RS07285	COG1530	ribonuclease E activity
MCA_RS07290	COG1643	Atp-dependent helicase
MCA_RS07295	COG0842	Transport permease protein
MCA_RS07320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCA_RS07330	COG2171	N-acyltransferase activity
MCA_RS07335	COG0436	Aminotransferase
MCA_RS07370	COG0590	tRNA wobble adenosine to inosine editing
MCA_RS07375	COG0247	lactate metabolic process
MCA_RS07380	COG0277	FAD linked oxidase domain protein
MCA_RS07385	COG0277	FAD linked oxidase domain protein
MCA_RS07435	COG4969	Belongs to the N-Me-Phe pilin family
MCA_RS07465	COG0859	PFAM glycosyl transferase family 9
MCA_RS07465	COG0457	Tetratricopeptide repeat
MCA_RS07495	COG2091	lysine biosynthetic process via aminoadipic acid
MCA_RS07510	COG0714	Associated with various cellular activities
MCA_RS07545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MCA_RS07595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MCA_RS07615	COG0646	methionine synthase
MCA_RS07615	COG1410	methionine synthase
MCA_RS07640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MCA_RS07645	COG1053	succinate dehydrogenase
MCA_RS07655	COG1393	Belongs to the ArsC family
MCA_RS07660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCA_RS07665	COG2897	thiosulfate sulfurtransferase activity
MCA_RS07670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCA_RS07695	COG1131	(ABC) transporter
MCA_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
MCA_RS07735	COG0513	Belongs to the DEAD box helicase family
MCA_RS07740	COG1064	alcohol dehydrogenase
MCA_RS07745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCA_RS07755	COG2723	6-phospho-beta-galactosidase activity
MCA_RS07760	COG1201	RNA secondary structure unwinding
MCA_RS07770	COG0004	ammonium transporteR
MCA_RS07775	COG3706	GGDEF domain
MCA_RS07790	COG3459	Glycosyltransferase 36 associated
MCA_RS07795	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MCA_RS07805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCA_RS07810	COG3122	Protein conserved in bacteria
MCA_RS07815	COG0564	pseudouridine synthase activity
MCA_RS07845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCA_RS07855	COG0375	protein maturation
MCA_RS07865	COG0409	Hydrogenase expression formation protein
MCA_RS07870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MCA_RS07910	COG5433	transposase activity
MCA_RS07925	COG1278	Cold shock
MCA_RS07955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCA_RS07960	COG2801	Transposase and inactivated derivatives
MCA_RS07990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MCA_RS08005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MCA_RS08015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MCA_RS08015	COG3264	Mechanosensitive ion channel
MCA_RS08025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCA_RS08025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MCA_RS08035	COG3038	cytochrome b561
MCA_RS08055	COG2192	nodulation
MCA_RS08070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCA_RS08080	COG2350	Protein conserved in bacteria
MCA_RS08085	COG2917	probably involved in intracellular septation
MCA_RS08095	COG0346	lactoylglutathione lyase activity
MCA_RS08120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MCA_RS08130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCA_RS08140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCA_RS08150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCA_RS08150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCA_RS08155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MCA_RS08160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCA_RS08165	COG0840	transmembrane signaling receptor activity
MCA_RS08170	COG0683	leucine binding
MCA_RS08175	COG1366	Belongs to the anti-sigma-factor antagonist family
MCA_RS08185	COG0288	reversible hydration of carbon dioxide
MCA_RS08195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MCA_RS08205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCA_RS08210	COG0302	gtp cyclohydrolase
MCA_RS08215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MCA_RS08220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCA_RS08235	COG4178	(ABC) transporter
MCA_RS08255	COG0174	glutamine synthetase
MCA_RS08260	COG0494	nUDIX hydrolase
MCA_RS08265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MCA_RS08270	COG0653	protein targeting
MCA_RS08275	COG0322	excinuclease ABC activity
MCA_RS08285	COG4191	Histidine kinase
MCA_RS08290	COG2902	Dehydrogenase
MCA_RS08300	COG1366	Belongs to the anti-sigma-factor antagonist family
MCA_RS08320	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
MCA_RS08325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MCA_RS08330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MCA_RS08340	COG0492	ferredoxin-NADP+ reductase activity
MCA_RS08345	COG1674	ftsk spoiiie
MCA_RS08360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MCA_RS08380	COG0459	protein refolding
MCA_RS08400	COG2963	transposase activity
MCA_RS08420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCA_RS08425	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MCA_RS08430	COG2204	response regulator
MCA_RS08440	COG2205	protein histidine kinase activity
MCA_RS08450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MCA_RS08465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCA_RS08480	COG2095	MarC family integral membrane protein
MCA_RS08485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCA_RS08510	COG3339	Conserved Protein
MCA_RS08535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MCA_RS08545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MCA_RS08545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MCA_RS08560	COG2301	Belongs to the HpcH HpaI aldolase family
MCA_RS08565	COG0045	succinate-CoA ligase (ADP-forming) activity
MCA_RS08570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MCA_RS08575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCA_RS08580	COG1490	D-aminoacyl-tRNA deacylase activity
MCA_RS08590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCA_RS08595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MCA_RS08600	COG0138	bifunctional purine biosynthesis protein purh
MCA_RS08610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MCA_RS08615	COG1765	OsmC-like protein
MCA_RS08640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCA_RS08675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MCA_RS08690	COG0642	Histidine kinase
MCA_RS08710	COG1858	cytochrome C peroxidase
MCA_RS08720	COG0589	response to stress
MCA_RS08730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MCA_RS08750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MCA_RS08755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MCA_RS08755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MCA_RS08760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MCA_RS08765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MCA_RS08775	COG0482	sulfurtransferase activity
MCA_RS08790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MCA_RS08795	COG0542	response to heat
MCA_RS08800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MCA_RS08805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MCA_RS08810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MCA_RS08820	COG0488	(ABC) transporter
MCA_RS08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCA_RS08855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MCA_RS08870	COG0825	malonyl-CoA metabolic process
MCA_RS08875	COG0037	tRNA processing
MCA_RS08895	COG1136	(ABC) transporter
MCA_RS08895	COG0577	efflux transmembrane transporter activity
MCA_RS08910	COG0826	peptidase U32
MCA_RS08915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MCA_RS08920	COG2096	Adenosyltransferase
MCA_RS08925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCA_RS08930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCA_RS08935	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MCA_RS08945	COG1360	Flagellar Motor Protein
MCA_RS08960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCA_RS08960	COG3153	acetyltransferase
MCA_RS08995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCA_RS09010	COG4948	Mandelate Racemase Muconate Lactonizing
MCA_RS09025	COG0028	Belongs to the TPP enzyme family
MCA_RS09030	COG3527	Alpha-acetolactate decarboxylase
MCA_RS09045	COG1136	(ABC) transporter
MCA_RS09045	COG0577	efflux transmembrane transporter activity
MCA_RS09075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCA_RS09085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MCA_RS09090	COG1534	Rna-binding protein
MCA_RS09095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCA_RS09100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCA_RS09105	COG0505	Belongs to the CarA family
MCA_RS09110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MCA_RS09115	COG0484	heat shock protein binding
MCA_RS09120	COG0443	Heat shock 70 kDa protein
MCA_RS09125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MCA_RS09130	COG1420	regulation of RNA biosynthetic process
MCA_RS09135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MCA_RS09140	COG0497	DNA recombination
MCA_RS09150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCA_RS09160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MCA_RS09165	COG0307	riboflavin synthase, alpha
MCA_RS09180	COG0514	ATP-dependent DNA helicase (RecQ)
MCA_RS09195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MCA_RS09200	COG1301	dicarboxylic acid transport
MCA_RS09220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MCA_RS09235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MCA_RS09240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MCA_RS09285	COG1196	nuclear chromosome segregation
MCA_RS09295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MCA_RS09320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCA_RS09355	COG1730	sister chromatid segregation
MCA_RS09360	COG1858	cytochrome C peroxidase
MCA_RS09365	COG0387	Pfam Sodium calcium exchanger
MCA_RS09390	COG2217	Heavy metal translocating P-type atpase
MCA_RS09400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MCA_RS09405	COG1252	NADH dehydrogenase
MCA_RS09415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCA_RS09425	COG0395	ABC-type sugar transport system, permease component
MCA_RS09450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MCA_RS09475	COG0148	phosphopyruvate hydratase activity
MCA_RS09495	COG0642	Histidine kinase
MCA_RS09520	COG3842	ATPase activity
MCA_RS09525	COG0746	molybdenum cofactor guanylyltransferase activity
MCA_RS09545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCA_RS09550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MCA_RS09560	COG0567	Dehydrogenase, E1 component
MCA_RS09565	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCA_RS09575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCA_RS09575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCA_RS09585	COG4206	TonB-dependent receptor
MCA_RS09590	COG2969	positive regulation of protein catabolic process
MCA_RS09595	COG0625	glutathione transferase activity
MCA_RS09600	COG2857	Cytochrome c1
MCA_RS09605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCA_RS09610	COG0723	plastoquinol--plastocyanin reductase activity
MCA_RS09615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MCA_RS09620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MCA_RS09625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MCA_RS09635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MCA_RS09640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MCA_RS09645	COG1127	ABC transporter
MCA_RS09650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MCA_RS09655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCA_RS09660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MCA_RS09670	COG0557	exoribonuclease II activity
MCA_RS09680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MCA_RS09685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MCA_RS09690	COG0330	HflC and HflK could
MCA_RS09695	COG0330	HflC and HflK could
MCA_RS09700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MCA_RS09705	COG1923	regulation of RNA biosynthetic process
MCA_RS09710	COG1472	Belongs to the glycosyl hydrolase 3 family
MCA_RS09715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MCA_RS09720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MCA_RS09735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MCA_RS09740	COG1199	ATP-dependent helicase activity
MCA_RS09750	COG0084	hydrolase, TatD family'
MCA_RS09765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MCA_RS09770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MCA_RS09775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MCA_RS09780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCA_RS09785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCA_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
MCA_RS09800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCA_RS09805	COG0416	fatty acid biosynthetic process
MCA_RS09810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MCA_RS09815	COG1399	metal-binding, possibly nucleic acid-binding protein
MCA_RS09820	COG0424	maF-like protein
MCA_RS09825	COG0741	lytic transglycosylase activity
MCA_RS09830	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MCA_RS09840	COG2132	Multicopper oxidase
MCA_RS09850	COG0442	prolyl-tRNA aminoacylation
MCA_RS09855	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MCA_RS09860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MCA_RS09870	COG2226	methyltransferase
MCA_RS09880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MCA_RS09890	COG0126	phosphoglycerate kinase activity
MCA_RS09895	COG1758	RNA polymerase activity
MCA_RS09900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCA_RS09910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MCA_RS09925	COG0741	lytic transglycosylase activity
MCA_RS09925	COG1388	LysM domain
MCA_RS09940	COG0012	GTP binding
MCA_RS09945	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MCA_RS09945	COG0662	Cupin 2, conserved barrel domain protein
MCA_RS09950	COG1519	Transferase
MCA_RS09955	COG0359	binds to the 23S rRNA
MCA_RS09965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MCA_RS09970	COG0360	Binds together with S18 to 16S ribosomal RNA
MCA_RS09975	COG0070	glutamate synthase
MCA_RS09975	COG0069	glutamate synthase activity
MCA_RS09975	COG0067	glutamate synthase
MCA_RS10000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCA_RS10005	COG0347	Belongs to the P(II) protein family
MCA_RS10015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MCA_RS10020	COG1166	arginine decarboxylase activity
MCA_RS10025	COG2084	Dehydrogenase
MCA_RS10040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MCA_RS10050	COG0436	Aminotransferase
MCA_RS10065	COG2308	Evidence 4 Homologs of previously reported genes of
MCA_RS10080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCA_RS10095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MCA_RS10100	COG0473	3-isopropylmalate dehydrogenase activity
MCA_RS10105	COG0066	3-isopropylmalate dehydratase activity
MCA_RS10110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MCA_RS10115	COG0563	adenylate kinase activity
MCA_RS10120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MCA_RS10125	COG2824	Alkylphosphonate utilization operon protein PhnA
MCA_RS10145	COG2217	Heavy metal translocating P-type atpase
MCA_RS10160	COG0418	dihydroorotase activity
MCA_RS10165	COG2853	Lipoprotein
MCA_RS10175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MCA_RS10180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCA_RS10185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MCA_RS10195	COG0129	dihydroxy-acid dehydratase activity
MCA_RS10205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCA_RS10205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MCA_RS10210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MCA_RS10225	COG0425	Belongs to the sulfur carrier protein TusA family
MCA_RS10230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCA_RS10230	COG1648	precorrin-2 dehydrogenase activity
MCA_RS10235	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MCA_RS10240	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MCA_RS10245	COG0237	dephospho-CoA kinase activity
MCA_RS10250	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MCA_RS10265	COG0525	valine-tRNA ligase activity
MCA_RS10275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MCA_RS10280	COG0795	lipopolysaccharide-transporting ATPase activity
MCA_RS10335	COG2951	lytic endotransglycosylase activity
MCA_RS10355	COG1449	Belongs to the glycosyl hydrolase 57 family
MCA_RS10365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCA_RS10370	COG0842	Transport permease protein
MCA_RS10375	COG1131	(ABC) transporter
MCA_RS10380	COG0248	Ppx GppA phosphatase
MCA_RS10390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCA_RS10395	COG0438	transferase activity, transferring glycosyl groups
MCA_RS10400	COG0367	asparagine synthase
MCA_RS10420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCA_RS10445	COG0004	ammonium transporteR
MCA_RS10460	COG0606	chelatase, subunit chli
MCA_RS10500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MCA_RS10505	COG3104	oligopeptide transport
MCA_RS10545	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCA_RS10550	COG0521	Mo-molybdopterin cofactor biosynthetic process
MCA_RS10555	COG1295	ribonuclease BN
MCA_RS10585	COG0587	DNA-directed DNA polymerase activity
MCA_RS10600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MCA_RS10630	COG1136	(ABC) transporter
MCA_RS10680	COG0432	Pfam Uncharacterised protein family UPF0047
MCA_RS10695	COG0300	oxidoreductase activity
MCA_RS10735	COG0463	Glycosyl transferase, family 2
MCA_RS10780	COG0556	nucleotide-excision repair
MCA_RS10785	COG0436	Aminotransferase
MCA_RS10790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCA_RS10795	COG0529	Catalyzes the synthesis of activated sulfate
MCA_RS10805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MCA_RS10815	COG1994	Peptidase M50
MCA_RS10820	COG0009	L-threonylcarbamoyladenylate synthase
MCA_RS10825	COG1214	PFAM Peptidase M22, glycoprotease
MCA_RS10830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MCA_RS10840	COG0745	RESPONSE REGULATOR receiver
MCA_RS10845	COG2205	protein histidine kinase activity
MCA_RS10850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MCA_RS10855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MCA_RS10860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MCA_RS10870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MCA_RS10890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCA_RS10895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MCA_RS10925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCA_RS10935	COG1538	Outer membrane efflux protein
MCA_RS10985	COG1090	epimerase
MCA_RS10990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MCA_RS10995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MCA_RS11000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCA_RS11005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MCA_RS11010	COG0268	Binds directly to 16S ribosomal RNA
MCA_RS11020	COG0196	riboflavin kinase activity
MCA_RS11025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MCA_RS11060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MCA_RS11065	COG0583	DNA-binding transcription factor activity
MCA_RS11085	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCA_RS11090	COG0346	lactoylglutathione lyase activity
MCA_RS11105	COG1741	Belongs to the pirin family
MCA_RS11110	COG0583	DNA-binding transcription factor activity
MCA_RS11115	COG0028	Belongs to the TPP enzyme family
MCA_RS11125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MCA_RS11130	COG1183	phosphatidylcholine synthase activity
MCA_RS11135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCA_RS11140	COG1573	uracil-dna glycosylase
MCA_RS11150	COG2205	protein histidine kinase activity
MCA_RS11155	COG0745	RESPONSE REGULATOR receiver
MCA_RS11170	COG0121	glutamine amidotransferase
MCA_RS11185	COG3150	esterase
MCA_RS11200	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MCA_RS11210	COG0778	Nitroreductase
MCA_RS11215	COG1797	cobyrinic acid a,c-diamide synthase activity
MCA_RS11255	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MCA_RS11285	COG1492	cobalamin metabolic process
MCA_RS11320	COG2226	methyltransferase
MCA_RS11330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCA_RS11335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MCA_RS11340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MCA_RS11345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MCA_RS11350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MCA_RS11355	COG1469	GTP cyclohydrolase I activity
MCA_RS11360	COG1229	Formylmethanofuran dehydrogenase subunit A
MCA_RS11375	COG0735	belongs to the Fur family
MCA_RS11415	COG0745	RESPONSE REGULATOR receiver
MCA_RS11420	COG2205	protein histidine kinase activity
MCA_RS11430	COG0540	Belongs to the ATCase OTCase family
MCA_RS11435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MCA_RS11440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MCA_RS11445	COG1678	Uncharacterized ACR, COG1678
MCA_RS11455	COG0189	ligase activity
MCA_RS11460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MCA_RS11465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCA_RS11470	COG1192	Involved in chromosome partitioning
MCA_RS11490	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MCA_RS11495	COG0203	ribosomal protein L17
MCA_RS11500	COG0202	RNA polymerase activity
MCA_RS11505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MCA_RS11510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MCA_RS11515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MCA_RS11520	COG0201	protein transport
MCA_RS11525	COG0200	Binds to the 23S rRNA
MCA_RS11530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MCA_RS11535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MCA_RS11540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MCA_RS11545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MCA_RS11550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MCA_RS11555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCA_RS11560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MCA_RS11565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MCA_RS11570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MCA_RS11575	COG0255	Belongs to the universal ribosomal protein uL29 family
MCA_RS11580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MCA_RS11585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCA_RS11590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MCA_RS11595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MCA_RS11600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCA_RS11605	COG0089	rRNA binding
MCA_RS11610	COG0088	Forms part of the polypeptide exit tunnel
MCA_RS11615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MCA_RS11620	COG0051	transcription antitermination factor activity, RNA binding
MCA_RS11625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCA_RS11630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCA_RS11635	COG0049	tRNA binding
MCA_RS11640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MCA_RS11655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MCA_RS11675	COG2925	Exonuclease
MCA_RS11685	COG2871	sodium ion transport
MCA_RS11690	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCA_RS11695	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCA_RS11710	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCA_RS11720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MCA_RS11750	COG2863	cytochrome
MCA_RS11755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCA_RS11760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MCA_RS11770	COG3256	nitric oxide reductase
MCA_RS11775	COG2010	Cytochrome c
MCA_RS11790	COG1388	LysM domain
MCA_RS11790	COG0741	lytic transglycosylase activity
MCA_RS11795	COG4654	Cytochrome c, class I
MCA_RS11805	COG2363	Small membrane protein
MCA_RS11810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCA_RS11830	COG0121	glutamine amidotransferase
MCA_RS11840	COG0438	transferase activity, transferring glycosyl groups
MCA_RS11860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MCA_RS11865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCA_RS11870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCA_RS11870	COG1042	CoA-binding domain protein
MCA_RS11870	COG0045	succinate-CoA ligase (ADP-forming) activity
MCA_RS11880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MCA_RS11895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MCA_RS11900	COG1181	Belongs to the D-alanine--D-alanine ligase family
MCA_RS11905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MCA_RS11910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCA_RS11915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MCA_RS11920	COG0772	Belongs to the SEDS family
MCA_RS11925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MCA_RS11930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCA_RS11935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MCA_RS11950	COG0275	rRNA processing
MCA_RS11955	COG2001	Belongs to the MraZ family
MCA_RS11960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MCA_RS11965	COG3115	cell septum assembly
MCA_RS11970	COG1196	nuclear chromosome segregation
MCA_RS11975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MCA_RS11985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCA_RS11990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCA_RS11995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCA_RS12005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCA_RS12020	COG1763	Mo-molybdopterin cofactor biosynthetic process
MCA_RS12050	COG0583	DNA-binding transcription factor activity
MCA_RS12090	COG0477	Major facilitator Superfamily
MCA_RS12100	COG2918	glutathione biosynthetic process
MCA_RS12115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MCA_RS12120	COG0483	inositol monophosphate 1-phosphatase activity
MCA_RS12125	COG0659	secondary active sulfate transmembrane transporter activity
MCA_RS12130	COG3852	Histidine kinase
MCA_RS12135	COG2204	response regulator
MCA_RS12145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCA_RS12145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCA_RS12150	COG1331	Highly conserved protein containing a thioredoxin domain
MCA_RS12160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MCA_RS12165	COG0511	ligase activity, forming carbon-carbon bonds
MCA_RS12165	COG5016	pyruvate
MCA_RS12180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCA_RS12185	COG2833	Protein of unknown function (DUF455)
MCA_RS12190	COG1049	propionate catabolic process, 2-methylcitrate cycle
MCA_RS12195	COG0123	including yeast histone deacetylase and acetoin utilization protein
MCA_RS12225	COG0285	dihydrofolate synthase activity
MCA_RS12230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MCA_RS12235	COG0159	tryptophan synthase activity
MCA_RS12240	COG0133	tryptophan synthase activity
MCA_RS12245	COG0135	phosphoribosylanthranilate isomerase activity
MCA_RS12250	COG0101	tRNA pseudouridine synthase activity
MCA_RS12260	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MCA_RS12285	COG1959	2 iron, 2 sulfur cluster binding
MCA_RS12290	COG2346	COG2346, Truncated hemoglobins
MCA_RS12300	COG0038	chloride channel
MCA_RS12320	COG0504	CTP synthase activity
MCA_RS12325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MCA_RS12330	COG0148	phosphopyruvate hydratase activity
MCA_RS12335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MCA_RS12340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MCA_RS12345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MCA_RS12350	COG0585	pseudouridine synthase activity
MCA_RS12355	COG1393	Belongs to the ArsC family
MCA_RS12370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MCA_RS12405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MCA_RS12410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MCA_RS12415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCA_RS12420	COG0071	Belongs to the small heat shock protein (HSP20) family
MCA_RS12425	COG0793	Belongs to the peptidase S41A family
MCA_RS12430	COG4942	peptidase
MCA_RS12435	COG0640	Transcriptional regulator
MCA_RS12440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCA_RS12445	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MCA_RS12450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCA_RS12455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MCA_RS12460	COG0058	SHG alpha-glucan phosphorylase activity
MCA_RS12470	COG3852	Histidine kinase
MCA_RS12490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCA_RS12495	COG0438	transferase activity, transferring glycosyl groups
MCA_RS12520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCA_RS12560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MCA_RS12620	COG3383	formate dehydrogenase (NAD+) activity
MCA_RS12635	COG4149	molybdate abc transporter
MCA_RS12640	COG0725	ABC transporter, periplasmic molybdate-binding protein
MCA_RS12650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MCA_RS12655	COG0546	phosphoglycolate phosphatase activity
MCA_RS12665	COG0512	Glutamine amidotransferase of anthranilate synthase
MCA_RS12670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MCA_RS12675	COG0134	indole-3-glycerol-phosphate synthase activity
MCA_RS12680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCA_RS12690	COG1858	cytochrome C peroxidase
MCA_RS12705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MCA_RS12720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MCA_RS12730	COG1067	ATP-dependent peptidase activity
MCA_RS12750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MCA_RS12755	COG0366	Alpha amylase catalytic
MCA_RS12760	COG0297	glycogen (starch) synthase activity
MCA_RS12765	COG1966	Carbon starvation protein
MCA_RS12770	COG3264	Mechanosensitive ion channel
MCA_RS12770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MCA_RS12795	COG3118	belongs to the thioredoxin family
MCA_RS12800	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MCA_RS12815	COG2010	Cytochrome c
MCA_RS12820	COG1686	Belongs to the peptidase S11 family
MCA_RS12825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MCA_RS12830	COG0733	neurotransmitter:sodium symporter activity
MCA_RS12835	COG2914	Belongs to the UPF0125 (RnfH) family
MCA_RS12840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCA_RS12845	COG0735	belongs to the Fur family
MCA_RS12850	COG4591	ABC-type transport system involved in lipoprotein release permease component
MCA_RS12855	COG1136	(ABC) transporter
MCA_RS12865	COG2333	competence protein COMEC
MCA_RS12865	COG0658	competence protein
MCA_RS12875	COG0175	sulfate reduction
MCA_RS12915	COG1569	PIN domain
MCA_RS12920	COG3311	Transcriptional regulator
MCA_RS12985	COG3609	addiction module antidote protein, CC2985 family
MCA_RS13000	COG1475	DNA binding
MCA_RS13135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCA_RS13175	COG2801	Transposase and inactivated derivatives
MCA_RS13185	COG2814	Major facilitator Superfamily
MCA_RS13190	COG3781	membrane
MCA_RS13210	COG0356	it plays a direct role in the translocation of protons across the membrane
MCA_RS13220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MCA_RS13220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCA_RS13230	COG5640	endopeptidase activity
MCA_RS13245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MCA_RS13255	COG0628	permease
MCA_RS13260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MCA_RS13265	COG2124	cytochrome p450
MCA_RS13290	COG1615	UPF0182 protein
MCA_RS13345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MCA_RS13350	COG3383	formate dehydrogenase (NAD+) activity
MCA_RS13355	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
MCA_RS13360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MCA_RS13365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MCA_RS13375	COG0315	cyclic pyranopterin monophosphate synthase activity
MCA_RS13390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCA_RS13400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MCA_RS13405	COG1234	tRNA 3'-trailer cleavage
MCA_RS13425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MCA_RS13430	COG0714	Associated with various cellular activities
MCA_RS13435	COG0586	Pfam SNARE associated Golgi protein
MCA_RS13440	COG1850	ribulose-bisphosphate carboxylase activity
MCA_RS13460	COG2208	phosphoserine phosphatase activity
MCA_RS13465	COG4206	TonB-dependent receptor
MCA_RS13490	COG2409	Drug exporters of the RND superfamily
MCA_RS13510	COG1335	isochorismatase
MCA_RS13540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MCA_RS13545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MCA_RS13550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCA_RS13555	COG0006	proline dipeptidase activity
MCA_RS13560	COG3079	Belongs to the UPF0149 family
MCA_RS13570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MCA_RS13575	COG4566	intracellular signal transduction
MCA_RS13600	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MCA_RS13615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCA_RS13625	COG0756	dUTP diphosphatase activity
MCA_RS13630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MCA_RS13640	COG3012	SEC-C Motif Domain Protein
MCA_RS13655	COG0791	NLP P60 protein
MCA_RS13660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCA_RS13665	COG0408	coproporphyrinogen oxidase activity
MCA_RS13670	COG2854	intermembrane phospholipid transfer
MCA_RS13680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MCA_RS13695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MCA_RS13700	COG1704	LemA family
MCA_RS13710	COG0140	phosphoribosyl-ATP diphosphatase activity
MCA_RS13715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MCA_RS13720	COG0107	imidazoleglycerol-phosphate synthase activity
MCA_RS13725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MCA_RS13730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MCA_RS13735	COG0131	Imidazoleglycerol-phosphate dehydratase
MCA_RS13745	COG2226	methyltransferase
MCA_RS13795	COG2914	Belongs to the UPF0125 (RnfH) family
MCA_RS13805	COG4659	FMN binding
MCA_RS13815	COG4656	Part of a membrane complex involved in electron transport
MCA_RS13820	COG2878	Part of a membrane complex involved in electron transport
MCA_RS13825	COG4657	Part of a membrane complex involved in electron transport
MCA_RS13840	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MCA_RS13855	COG0531	amino acid
MCA_RS13860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCA_RS13885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MCA_RS13895	COG0009	L-threonylcarbamoyladenylate synthase
MCA_RS13905	COG2922	Belongs to the Smg family
MCA_RS13910	COG0758	DNA mediated transformation
MCA_RS13920	COG0242	peptide deformylase activity
MCA_RS13925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCA_RS13940	COG5000	phosphorelay sensor kinase activity
MCA_RS13945	COG2204	response regulator
MCA_RS13950	COG0569	domain protein
MCA_RS13965	COG1217	gtp-binding protein TYPA
MCA_RS13990	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MCA_RS13995	COG1229	Formylmethanofuran dehydrogenase subunit A
MCA_RS14015	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MCA_RS14030	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MCA_RS14035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MCA_RS14040	COG0189	ligase activity
MCA_RS14080	COG3876	Protein conserved in bacteria
MCA_RS14085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCA_RS14095	COG0037	tRNA processing
MCA_RS14110	COG1959	2 iron, 2 sulfur cluster binding
MCA_RS14115	COG1104	cysteine desulfurase activity
MCA_RS14120	COG0316	Belongs to the HesB IscA family
MCA_RS14125	COG0105	UTP biosynthetic process
MCA_RS14130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MCA_RS14140	COG0124	histidyl-tRNA synthetase
MCA_RS14150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCA_RS14155	COG1160	GTP binding
MCA_RS14160	COG4657	Part of a membrane complex involved in electron transport
MCA_RS14165	COG2878	Part of a membrane complex involved in electron transport
MCA_RS14185	COG4660	Part of a membrane complex involved in electron transport
MCA_RS14190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCA_RS14340	COG5005	Phage virion morphogenesis
MCA_RS14430	COG1525	nuclease
MCA_RS14455	COG0776	regulation of translation
MCA_RS14550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCA_RS14560	COG0363	glucosamine-6-phosphate deaminase activity
MCA_RS14565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MCA_RS14580	COG0194	GDP metabolic process
MCA_RS14585	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MCA_RS14590	COG4191	Histidine kinase
MCA_RS14595	COG4783	chaperone-mediated protein folding
MCA_RS14600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCA_RS14605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MCA_RS14615	COG1011	Hydrolase
MCA_RS14630	COG0671	phosphoesterase, PA-phosphatase related
MCA_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
MCA_RS14640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCA_RS14645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MCA_RS14650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MCA_RS14655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCA_RS14660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MCA_RS14665	COG1610	YqeY-like protein
MCA_RS14670	COG0358	DNA primase activity
MCA_RS14690	COG0142	geranyltranstransferase activity
MCA_RS14695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCA_RS14710	COG0352	thiamine-phosphate diphosphorylase activity
MCA_RS14720	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCA_RS14725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCA_RS14730	COG2226	methyltransferase
MCA_RS14735	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCA_RS14740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCA_RS14745	COG2002	toxin-antitoxin pair type II binding
MCA_RS14760	COG1196	nuclear chromosome segregation
MCA_RS14805	COG0702	epimerase
MCA_RS14810	COG0702	epimerase
MCA_RS14815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCA_RS14815	COG0574	Belongs to the PEP-utilizing enzyme family
MCA_RS14820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MCA_RS14830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MCA_RS14835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MCA_RS14845	COG1561	YicC-like family, N-terminal region
MCA_RS14860	COG0187	DNA topoisomerase II activity
MCA_RS14865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCA_RS14870	COG0592	DNA-directed DNA polymerase activity
MCA_RS14875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MCA_RS14880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MCA_RS14885	COG0594	ribonuclease P activity
MCA_RS14890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MCA_RS14895	COG0706	membrane insertase activity
MCA_RS14900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MCA_RS14910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MCA_RS14915	COG0191	fructose-bisphosphate aldolase activity
MCA_RS14935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MCA_RS14940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MCA_RS14945	COG0191	fructose-bisphosphate aldolase activity
MCA_RS14965	COG3954	Phosphoribulokinase
MCA_RS14975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MCA_RS14980	COG0314	molybdopterin synthase activity
MCA_RS14990	COG3781	membrane
MCA_RS14995	COG3360	Dodecin
MCA_RS15000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MCA_RS15005	COG0181	hydroxymethylbilane synthase activity
MCA_RS15010	COG1587	Uroporphyrinogen-III synthase
MCA_RS15020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MCA_RS15035	COG0850	regulation of cytokinetic process
MCA_RS15040	COG2894	cell division
MCA_RS15045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MCA_RS15060	COG0473	3-isopropylmalate dehydrogenase activity
MCA_RS15065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCA_RS15075	COG1696	Membrane protein involved in D-alanine export
MCA_RS15100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCA_RS15105	COG1950	PFAM Membrane protein of
MCA_RS15130	COG2304	oxidoreductase activity
MCA_RS15145	COG0018	arginyl-trna synthetase
MCA_RS15155	COG1611	Belongs to the LOG family
MCA_RS15165	COG2943	transferase activity, transferring hexosyl groups
MCA_RS15165	COG3416	Protein conserved in bacteria
MCA_RS15175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MCA_RS15200	COG3852	Histidine kinase
MCA_RS15235	COG0542	response to heat
MCA_RS15245	COG3220	belongs to the UPF0276 family
MCA_RS15260	COG1585	Membrane protein implicated in regulation of membrane protease activity
MCA_RS15265	COG0330	HflC and HflK could
MCA_RS15300	COG2226	methyltransferase
MCA_RS15360	COG2801	Transposase and inactivated derivatives
MCA_RS15375	COG0732	type I restriction modification DNA specificity domain
MCA_RS15455	COG2369	cell adhesion