locus-tag	class	description
MEALZ_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MEALZ_RS00010	COG0592	DNA-directed DNA polymerase activity
MEALZ_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MEALZ_RS00020	COG0187	DNA topoisomerase II activity
MEALZ_RS00085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MEALZ_RS00105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MEALZ_RS00115	COG3012	SEC-C Motif Domain Protein
MEALZ_RS00125	COG1765	OsmC-like protein
MEALZ_RS00130	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MEALZ_RS00210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MEALZ_RS00230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MEALZ_RS00255	COG4251	negative regulation of phosphorylation
MEALZ_RS00260	COG2198	Histidine kinase
MEALZ_RS00260	COG0784	Response regulator, receiver
MEALZ_RS00260	COG0643	Histidine kinase
MEALZ_RS00265	COG5002	protein histidine kinase activity
MEALZ_RS00265	COG5001	Diguanylate cyclase
MEALZ_RS00275	COG3100	YcgL domain-containing protein
MEALZ_RS00305	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS00315	COG1215	transferase activity, transferring glycosyl groups
MEALZ_RS00330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MEALZ_RS00350	COG0583	DNA-binding transcription factor activity
MEALZ_RS00365	COG1217	gtp-binding protein TYPA
MEALZ_RS00370	COG0131	Imidazoleglycerol-phosphate dehydratase
MEALZ_RS00375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MEALZ_RS00380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MEALZ_RS00385	COG0107	imidazoleglycerol-phosphate synthase activity
MEALZ_RS00390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MEALZ_RS00395	COG0140	phosphoribosyl-ATP diphosphatase activity
MEALZ_RS00400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MEALZ_RS00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MEALZ_RS00410	COG0805	protein transport
MEALZ_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS00440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MEALZ_RS00445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MEALZ_RS00450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MEALZ_RS00455	COG1610	YqeY-like protein
MEALZ_RS00460	COG0358	DNA primase activity
MEALZ_RS00475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MEALZ_RS00480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MEALZ_RS00485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MEALZ_RS00490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MEALZ_RS00500	COG1666	GTP binding
MEALZ_RS00505	COG0617	tRNA 3'-terminal CCA addition
MEALZ_RS00510	COG0730	response to heat
MEALZ_RS00520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MEALZ_RS00520	COG0519	Catalyzes the synthesis of GMP from XMP
MEALZ_RS00530	COG0166	Belongs to the GPI family
MEALZ_RS00570	COG1132	(ABC) transporter
MEALZ_RS00600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MEALZ_RS00605	COG1127	ABC transporter
MEALZ_RS00625	COG1858	cytochrome C peroxidase
MEALZ_RS00630	COG3391	amine dehydrogenase activity
MEALZ_RS00665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MEALZ_RS00670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MEALZ_RS00675	COG2003	Belongs to the UPF0758 family
MEALZ_RS00680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MEALZ_RS00685	COG0756	dUTP diphosphatase activity
MEALZ_RS00695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MEALZ_RS00720	COG4221	oxidoreductase activity
MEALZ_RS00725	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MEALZ_RS00735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MEALZ_RS00740	COG0018	arginyl-trna synthetase
MEALZ_RS00760	COG0134	indole-3-glycerol-phosphate synthase activity
MEALZ_RS00765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MEALZ_RS00770	COG0512	Glutamine amidotransferase of anthranilate synthase
MEALZ_RS00780	COG0179	Fumarylacetoacetate (FAA) hydrolase
MEALZ_RS00785	COG0642	Histidine kinase
MEALZ_RS00795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MEALZ_RS00810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MEALZ_RS00820	COG2022	thiamine diphosphate biosynthetic process
MEALZ_RS00820	COG2104	thiamine diphosphate biosynthetic process
MEALZ_RS00825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MEALZ_RS00830	COG1132	(ABC) transporter
MEALZ_RS00845	COG0393	Putative heavy-metal-binding
MEALZ_RS00885	COG2217	Heavy metal translocating P-type atpase
MEALZ_RS00895	COG0204	Acyl-transferase
MEALZ_RS00900	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
MEALZ_RS00905	COG0500	methyltransferase
MEALZ_RS00985	COG3385	transposase activity
MEALZ_RS01035	COG0210	DNA helicase
MEALZ_RS01065	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MEALZ_RS01075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MEALZ_RS01080	COG3383	formate dehydrogenase (NAD+) activity
MEALZ_RS01120	COG2274	protein secretion by the type I secretion system
MEALZ_RS01125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MEALZ_RS01135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MEALZ_RS01195	COG1030	water channel activity
MEALZ_RS01200	COG0330	HflC and HflK could
MEALZ_RS01220	COG0583	DNA-binding transcription factor activity
MEALZ_RS01235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MEALZ_RS01240	COG4208	sulfate ABC transporter
MEALZ_RS01250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MEALZ_RS01260	COG1960	acyl-CoA dehydrogenase activity
MEALZ_RS01265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MEALZ_RS01275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEALZ_RS01280	COG0644	oxidoreductase
MEALZ_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MEALZ_RS01305	COG1105	Belongs to the carbohydrate kinase PfkB family
MEALZ_RS01315	COG3706	GGDEF domain
MEALZ_RS01335	COG0446	pyridine nucleotide-disulphide oxidoreductase
MEALZ_RS01350	COG1294	oxidase, subunit
MEALZ_RS01360	COG2205	protein histidine kinase activity
MEALZ_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MEALZ_RS01360	COG0784	Response regulator, receiver
MEALZ_RS01360	COG2198	Histidine kinase
MEALZ_RS01365	COG0433	COG0433 Predicted ATPase
MEALZ_RS01380	COG0114	fumarate hydratase activity
MEALZ_RS01405	COG1013	pyruvate-flavodoxin oxidoreductase activity
MEALZ_RS01410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MEALZ_RS01410	COG0674	pyruvate-flavodoxin oxidoreductase activity
MEALZ_RS01420	COG2337	Toxic component of a toxin-antitoxin (TA) module
MEALZ_RS01435	COG2161	toxin-antitoxin pair type II binding
MEALZ_RS01485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MEALZ_RS01500	COG0606	chelatase, subunit chli
MEALZ_RS01505	COG2960	long-chain fatty acid transporting porin activity
MEALZ_RS01510	COG1846	Transcriptional regulator
MEALZ_RS01520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MEALZ_RS01530	COG2161	toxin-antitoxin pair type II binding
MEALZ_RS01535	COG4115	mRNA cleavage
MEALZ_RS01540	COG3045	CreA protein
MEALZ_RS01580	COG0714	Associated with various cellular activities
MEALZ_RS01595	COG0445	tRNA wobble uridine modification
MEALZ_RS01600	COG0357	Ribosomal RNA small subunit methyltransferase G
MEALZ_RS01605	COG1192	Involved in chromosome partitioning
MEALZ_RS01610	COG1475	DNA binding
MEALZ_RS01620	COG0356	it plays a direct role in the translocation of protons across the membrane
MEALZ_RS01630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MEALZ_RS01635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MEALZ_RS01640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MEALZ_RS01645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MEALZ_RS01650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MEALZ_RS01655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MEALZ_RS01660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MEALZ_RS01665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MEALZ_RS01700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MEALZ_RS01715	COG0446	pyridine nucleotide-disulphide oxidoreductase
MEALZ_RS01720	COG3592	Divergent 4Fe-4S mono-cluster
MEALZ_RS01750	COG1136	(ABC) transporter
MEALZ_RS01750	COG0577	efflux transmembrane transporter activity
MEALZ_RS01765	COG1309	transcriptional regulator
MEALZ_RS01775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MEALZ_RS01780	COG1335	isochorismatase
MEALZ_RS01800	COG1201	RNA secondary structure unwinding
MEALZ_RS01815	COG0513	Belongs to the DEAD box helicase family
MEALZ_RS01825	COG0194	GDP metabolic process
MEALZ_RS01840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MEALZ_RS01845	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MEALZ_RS01850	COG1252	NADH dehydrogenase
MEALZ_RS01855	COG0415	Belongs to the DNA photolyase family
MEALZ_RS01900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MEALZ_RS01920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MEALZ_RS01955	COG1570	exodeoxyribonuclease VII activity
MEALZ_RS01960	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MEALZ_RS01975	COG2920	part of a sulfur-relay system
MEALZ_RS01980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MEALZ_RS02000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MEALZ_RS02005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MEALZ_RS02015	COG0826	peptidase U32
MEALZ_RS02020	COG1490	D-aminoacyl-tRNA deacylase activity
MEALZ_RS02045	COG3220	belongs to the UPF0276 family
MEALZ_RS02060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MEALZ_RS02065	COG4660	Part of a membrane complex involved in electron transport
MEALZ_RS02070	COG4659	FMN binding
MEALZ_RS02080	COG4656	Part of a membrane complex involved in electron transport
MEALZ_RS02085	COG2878	Part of a membrane complex involved in electron transport
MEALZ_RS02090	COG4657	Part of a membrane complex involved in electron transport
MEALZ_RS02095	COG0659	secondary active sulfate transmembrane transporter activity
MEALZ_RS02110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MEALZ_RS02115	COG0653	protein targeting
MEALZ_RS02120	COG0058	SHG alpha-glucan phosphorylase activity
MEALZ_RS02125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MEALZ_RS02135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MEALZ_RS02140	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MEALZ_RS02145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MEALZ_RS02155	COG4942	peptidase
MEALZ_RS02160	COG0793	Belongs to the peptidase S41A family
MEALZ_RS02165	COG2861	carbohydrate metabolic process
MEALZ_RS02190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MEALZ_RS02225	COG1250	3-hydroxyacyl-CoA dehydrogenase
MEALZ_RS02225	COG1024	Enoyl-CoA hydratase
MEALZ_RS02230	COG0183	Belongs to the thiolase family
MEALZ_RS02250	COG0482	sulfurtransferase activity
MEALZ_RS02255	COG0425	Belongs to the sulfur carrier protein TusA family
MEALZ_RS02265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MEALZ_RS02270	COG0494	nUDIX hydrolase
MEALZ_RS02285	COG3609	addiction module antidote protein, CC2985 family
MEALZ_RS02300	COG3549	Plasmid maintenance system killer
MEALZ_RS02330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MEALZ_RS02335	COG1459	type II secretion system
MEALZ_RS02375	COG1943	Transposase
MEALZ_RS02390	COG0714	Associated with various cellular activities
MEALZ_RS02410	COG0656	L-ascorbic acid biosynthetic process
MEALZ_RS02430	COG0343	queuine tRNA-ribosyltransferase activity
MEALZ_RS02435	COG1862	Preprotein translocase
MEALZ_RS02440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MEALZ_RS02445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MEALZ_RS02460	COG0105	UTP biosynthetic process
MEALZ_RS02465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MEALZ_RS02475	COG0124	histidyl-tRNA synthetase
MEALZ_RS02485	COG2976	Protein conserved in bacteria
MEALZ_RS02490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MEALZ_RS02495	COG1160	GTP binding
MEALZ_RS02500	COG4251	negative regulation of phosphorylation
MEALZ_RS02505	COG0784	Response regulator, receiver
MEALZ_RS02520	COG0432	Pfam Uncharacterised protein family UPF0047
MEALZ_RS02570	COG0646	methionine synthase
MEALZ_RS02570	COG1410	methionine synthase
MEALZ_RS02575	COG2862	Uncharacterized protein family, UPF0114
MEALZ_RS02590	COG3122	Protein conserved in bacteria
MEALZ_RS02600	COG0686	Belongs to the AlaDH PNT family
MEALZ_RS02620	COG0039	L-malate dehydrogenase activity
MEALZ_RS02645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MEALZ_RS02650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MEALZ_RS02655	COG0513	Belongs to the DEAD box helicase family
MEALZ_RS02660	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MEALZ_RS02665	COG0511	ligase activity, forming carbon-carbon bonds
MEALZ_RS02665	COG5016	pyruvate
MEALZ_RS02675	COG4774	siderophore transport
MEALZ_RS02690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MEALZ_RS02695	COG0316	Belongs to the HesB IscA family
MEALZ_RS02705	COG0739	heme binding
MEALZ_RS02710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MEALZ_RS02745	COG1222	aaa ATPase
MEALZ_RS02755	COG0488	(ABC) transporter
MEALZ_RS02770	COG0284	orotidine-5'-phosphate decarboxylase activity
MEALZ_RS02780	COG2204	response regulator
MEALZ_RS02790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MEALZ_RS02795	COG1381	Involved in DNA repair and RecF pathway recombination
MEALZ_RS02800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MEALZ_RS02805	COG0571	ribonuclease III activity
MEALZ_RS02815	COG0681	Belongs to the peptidase S26 family
MEALZ_RS02820	COG0481	GTPase activity
MEALZ_RS02825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MEALZ_RS02870	COG2885	chlorophyll binding
MEALZ_RS02900	COG3385	transposase activity
MEALZ_RS02905	COG0535	radical SAM domain protein
MEALZ_RS02925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MEALZ_RS02935	COG3038	cytochrome b561
MEALZ_RS02940	COG0167	dihydroorotate dehydrogenase activity
MEALZ_RS02955	COG0514	ATP-dependent DNA helicase (RecQ)
MEALZ_RS02975	COG0488	(ABC) transporter
MEALZ_RS02985	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS02990	COG3100	YcgL domain-containing protein
MEALZ_RS02990	COG0561	phosphatase activity
MEALZ_RS02995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEALZ_RS03005	COG4988	ABC transporter
MEALZ_RS03010	COG0390	transport system, permease component
MEALZ_RS03015	COG3789	protein conserved in bacteria
MEALZ_RS03020	COG1842	Phage shock protein A
MEALZ_RS03040	COG5463	Belongs to the UPF0441 family
MEALZ_RS03045	COG0754	glutathionylspermidine amidase activity
MEALZ_RS03060	COG2969	positive regulation of protein catabolic process
MEALZ_RS03065	COG0625	glutathione transferase activity
MEALZ_RS03070	COG2857	Cytochrome c1
MEALZ_RS03075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MEALZ_RS03080	COG0723	plastoquinol--plastocyanin reductase activity
MEALZ_RS03085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MEALZ_RS03090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MEALZ_RS03095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MEALZ_RS03100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MEALZ_RS03110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MEALZ_RS03115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MEALZ_RS03120	COG1127	ABC transporter
MEALZ_RS03135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MEALZ_RS03145	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MEALZ_RS03150	COG1137	ATPase activity
MEALZ_RS03165	COG1660	Displays ATPase and GTPase activities
MEALZ_RS03175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MEALZ_RS03180	COG2894	cell division
MEALZ_RS03185	COG0850	regulation of cytokinetic process
MEALZ_RS03190	COG0306	phosphate transporter
MEALZ_RS03195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MEALZ_RS03205	COG3853	Toxic anion resistance protein (TelA)
MEALZ_RS03230	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MEALZ_RS03235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MEALZ_RS03240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MEALZ_RS03245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MEALZ_RS03250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MEALZ_RS03255	COG0617	tRNA 3'-terminal CCA addition
MEALZ_RS03280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MEALZ_RS03290	COG0525	valine-tRNA ligase activity
MEALZ_RS03305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MEALZ_RS03310	COG0237	dephospho-CoA kinase activity
MEALZ_RS03315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MEALZ_RS03320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MEALZ_RS03330	COG0443	Heat shock 70 kDa protein
MEALZ_RS03340	COG0484	heat shock protein binding
MEALZ_RS03405	COG0837	glucose binding
MEALZ_RS03435	COG0751	glycine-tRNA ligase activity
MEALZ_RS03450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MEALZ_RS03480	COG1063	alcohol dehydrogenase
MEALZ_RS03510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MEALZ_RS03530	COG1086	Polysaccharide biosynthesis protein
MEALZ_RS03535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MEALZ_RS03540	COG1083	cytidylyl-transferase
MEALZ_RS03555	COG1216	Glycosyl transferase, family 2
MEALZ_RS03575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MEALZ_RS03600	COG3475	LICD family
MEALZ_RS03605	COG2089	acid synthase
MEALZ_RS03610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MEALZ_RS03640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MEALZ_RS03645	COG4137	Cytochrome C assembly protein
MEALZ_RS03650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MEALZ_RS03655	COG0228	four-way junction DNA binding
MEALZ_RS03660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MEALZ_RS03665	COG0336	Belongs to the RNA methyltransferase TrmD family
MEALZ_RS03670	COG0335	large ribosomal subunit rRNA binding
MEALZ_RS03700	COG2414	aldehyde ferredoxin oxidoreductase
MEALZ_RS03725	COG2124	cytochrome p450
MEALZ_RS03750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MEALZ_RS03755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MEALZ_RS03765	COG1393	Belongs to the ArsC family
MEALZ_RS03770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MEALZ_RS03775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MEALZ_RS03835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MEALZ_RS03870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MEALZ_RS03890	COG3706	GGDEF domain
MEALZ_RS03900	COG2951	lytic endotransglycosylase activity
MEALZ_RS03920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MEALZ_RS03935	COG1477	protein flavinylation
MEALZ_RS03945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MEALZ_RS03955	COG0729	surface antigen
MEALZ_RS03985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MEALZ_RS03990	COG0523	cobalamin synthesis protein
MEALZ_RS04010	COG1229	Formylmethanofuran dehydrogenase subunit A
MEALZ_RS04020	COG1469	GTP cyclohydrolase I activity
MEALZ_RS04030	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MEALZ_RS04035	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MEALZ_RS04040	COG0492	ferredoxin-NADP+ reductase activity
MEALZ_RS04050	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MEALZ_RS04060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MEALZ_RS04070	COG0488	(ABC) transporter
MEALZ_RS04085	COG2197	response regulator
MEALZ_RS04095	COG3001	Fructosamine kinase
MEALZ_RS04100	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MEALZ_RS04115	COG1074	ATP-dependent DNA helicase activity
MEALZ_RS04125	COG0004	ammonium transporteR
MEALZ_RS04135	COG0004	ammonium transporteR
MEALZ_RS04140	COG0347	Belongs to the P(II) protein family
MEALZ_RS04145	COG0174	glutamine synthetase
MEALZ_RS04150	COG3852	Histidine kinase
MEALZ_RS04155	COG2204	response regulator
MEALZ_RS04160	COG3958	Transketolase
MEALZ_RS04165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MEALZ_RS04170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MEALZ_RS04185	COG0784	Response regulator, receiver
MEALZ_RS04215	COG0604	alcohol dehydrogenase
MEALZ_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS04215	COG3321	synthase
MEALZ_RS04225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MEALZ_RS04225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MEALZ_RS04235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MEALZ_RS04240	COG1702	phosphate starvation-inducible protein PhoH
MEALZ_RS04250	COG4535	Mg2 and Co2 transporter CorC
MEALZ_RS04285	COG0436	Aminotransferase
MEALZ_RS04290	COG0556	nucleotide-excision repair
MEALZ_RS04305	COG4251	negative regulation of phosphorylation
MEALZ_RS04325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MEALZ_RS04330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MEALZ_RS04335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MEALZ_RS04340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MEALZ_RS04345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MEALZ_RS04350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MEALZ_RS04350	COG0072	phenylalanine-tRNA ligase activity
MEALZ_RS04355	COG0776	regulation of translation
MEALZ_RS04395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MEALZ_RS04430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MEALZ_RS04445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MEALZ_RS04455	COG3852	Histidine kinase
MEALZ_RS04460	COG1100	Small GTP-binding protein
MEALZ_RS04465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MEALZ_RS04465	COG4191	Histidine kinase
MEALZ_RS04470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MEALZ_RS04480	COG2204	response regulator
MEALZ_RS04485	COG4191	Histidine kinase
MEALZ_RS04495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MEALZ_RS04500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MEALZ_RS04505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MEALZ_RS04515	COG0779	Required for maturation of 30S ribosomal subunits
MEALZ_RS04520	COG2251	uridine kinase activity
MEALZ_RS04520	COG0195	Participates in both transcription termination and antitermination
MEALZ_RS04525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MEALZ_RS04530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MEALZ_RS04535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MEALZ_RS04540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MEALZ_RS04545	COG1185	polyribonucleotide nucleotidyltransferase activity
MEALZ_RS04550	COG2010	Cytochrome c
MEALZ_RS04565	COG1214	PFAM Peptidase M22, glycoprotease
MEALZ_RS04565	COG0456	acetyltransferase
MEALZ_RS04580	COG4206	TonB-dependent receptor
MEALZ_RS04590	COG1492	cobalamin metabolic process
MEALZ_RS04595	COG0406	alpha-ribazole phosphatase activity
MEALZ_RS04600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MEALZ_RS04605	COG1598	PFAM Uncharacterised protein family UPF0150
MEALZ_RS04625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MEALZ_RS04630	COG0778	Nitroreductase
MEALZ_RS04635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MEALZ_RS04640	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MEALZ_RS04645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MEALZ_RS04655	COG1054	Belongs to the UPF0176 family
MEALZ_RS04670	COG0366	Alpha amylase catalytic
MEALZ_RS04700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MEALZ_RS04750	COG2801	Transposase and inactivated derivatives
MEALZ_RS04775	COG3128	pkhd-type hydroxylase
MEALZ_RS04815	COG0784	Response regulator, receiver
MEALZ_RS04815	COG0835	chemotaxis
MEALZ_RS04820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MEALZ_RS04825	COG1815	bacterial-type flagellum-dependent cell motility
MEALZ_RS04835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MEALZ_RS04840	COG1749	Flagellar hook protein flgE
MEALZ_RS04845	COG4787	bacterial-type flagellum-dependent cell motility
MEALZ_RS04850	COG4786	Flagellar basal body rod
MEALZ_RS04860	COG1706	bacterial-type flagellum-dependent cell motility
MEALZ_RS04865	COG3951	Flagellar rod assembly protein muramidase FlgJ
MEALZ_RS04865	COG1705	Flagellar rod assembly protein muramidase FlgJ
MEALZ_RS04875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MEALZ_RS04890	COG1254	Belongs to the acylphosphatase family
MEALZ_RS04895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MEALZ_RS04895	COG0116	Belongs to the methyltransferase superfamily
MEALZ_RS04905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MEALZ_RS04925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MEALZ_RS04925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MEALZ_RS04930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MEALZ_RS04960	COG1162	GTPase activity
MEALZ_RS04965	COG0501	Belongs to the peptidase M48B family
MEALZ_RS04970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MEALZ_RS04975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MEALZ_RS04985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MEALZ_RS04990	COG2998	abc-type tungstate transport system, permease component
MEALZ_RS05005	COG0352	thiamine-phosphate diphosphorylase activity
MEALZ_RS05010	COG0351	phosphomethylpyrimidine kinase
MEALZ_RS05015	COG1981	membrane
MEALZ_RS05020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MEALZ_RS05025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MEALZ_RS05035	COG0217	transcriptional regulatory protein
MEALZ_RS05045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MEALZ_RS05050	COG0632	four-way junction helicase activity
MEALZ_RS05055	COG2255	four-way junction helicase activity
MEALZ_RS05060	COG0824	Thioesterase
MEALZ_RS05080	COG0823	Involved in the tonB-independent uptake of proteins
MEALZ_RS05085	COG2885	chlorophyll binding
MEALZ_RS05090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MEALZ_RS05095	COG0602	queuosine metabolic process
MEALZ_RS05100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MEALZ_RS05110	COG0582	viral genome integration into host DNA
MEALZ_RS05115	COG3530	Putative quorum-sensing-regulated virulence factor
MEALZ_RS05230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MEALZ_RS05235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MEALZ_RS05260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MEALZ_RS05270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MEALZ_RS05315	COG2239	Acts as a magnesium transporter
MEALZ_RS05360	COG1042	CoA-binding domain protein
MEALZ_RS05360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MEALZ_RS05360	COG0045	succinate-CoA ligase (ADP-forming) activity
MEALZ_RS05370	COG2308	Evidence 4 Homologs of previously reported genes of
MEALZ_RS05380	COG5001	Diguanylate cyclase
MEALZ_RS05380	COG5002	protein histidine kinase activity
MEALZ_RS05385	COG1215	transferase activity, transferring glycosyl groups
MEALZ_RS05390	COG3769	mannosylglycerate metabolic process
MEALZ_RS05395	COG5001	Diguanylate cyclase
MEALZ_RS05395	COG3300	MHYT domain
MEALZ_RS05410	COG2119	membrane
MEALZ_RS05445	COG3706	GGDEF domain
MEALZ_RS05465	COG0281	malic enzyme
MEALZ_RS05470	COG0058	SHG alpha-glucan phosphorylase activity
MEALZ_RS05475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MEALZ_RS05480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MEALZ_RS05500	COG0443	Heat shock 70 kDa protein
MEALZ_RS05515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MEALZ_RS05545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MEALZ_RS05555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MEALZ_RS05575	COG2193	ferroxidase activity
MEALZ_RS05595	COG2223	nitrite transmembrane transporter activity
MEALZ_RS05605	COG0678	peroxiredoxin activity
MEALZ_RS05640	COG0659	secondary active sulfate transmembrane transporter activity
MEALZ_RS05665	COG2010	Cytochrome c
MEALZ_RS05690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MEALZ_RS05715	COG2010	Cytochrome c
MEALZ_RS05715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MEALZ_RS05720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MEALZ_RS05745	COG3424	synthase
MEALZ_RS05770	COG0556	nucleotide-excision repair
MEALZ_RS05795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MEALZ_RS05815	COG2361	Protein of unknown function DUF86
MEALZ_RS05900	COG4279	zinc finger
MEALZ_RS05915	COG3034	peptidoglycan biosynthetic process
MEALZ_RS05925	COG1760	l-serine dehydratase
MEALZ_RS05955	COG0033	Phosphoglucomutase
MEALZ_RS05975	COG1376	ErfK ybiS ycfS ynhG family protein
MEALZ_RS05980	COG2974	May be involved in recombination
MEALZ_RS05995	COG3028	Belongs to the UPF0307 family
MEALZ_RS06000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MEALZ_RS06015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MEALZ_RS06030	COG0019	diaminopimelate decarboxylase activity
MEALZ_RS06035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MEALZ_RS06095	COG1943	Transposase
MEALZ_RS06120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MEALZ_RS06125	COG1393	Belongs to the ArsC family
MEALZ_RS06135	COG4636	protein conserved in cyanobacteria
MEALZ_RS06140	COG2171	N-acyltransferase activity
MEALZ_RS06145	COG0436	Aminotransferase
MEALZ_RS06160	COG1229	Formylmethanofuran dehydrogenase subunit A
MEALZ_RS06185	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MEALZ_RS06190	COG2218	PFAM glutamate synthase alpha subunit domain protein
MEALZ_RS06205	COG3707	response regulator
MEALZ_RS06210	COG2223	nitrite transmembrane transporter activity
MEALZ_RS06215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MEALZ_RS06225	COG0384	phenazine biosynthesis protein PhzF
MEALZ_RS06230	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MEALZ_RS06235	COG2815	serine threonine protein kinase
MEALZ_RS06235	COG0515	serine threonine protein kinase
MEALZ_RS06255	COG0589	response to stress
MEALZ_RS06265	COG0488	(ABC) transporter
MEALZ_RS06275	COG1252	NADH dehydrogenase
MEALZ_RS06285	COG2203	Gaf domain
MEALZ_RS06285	COG4251	negative regulation of phosphorylation
MEALZ_RS06285	COG5001	Diguanylate cyclase
MEALZ_RS06285	COG3706	GGDEF domain
MEALZ_RS06295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MEALZ_RS06305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MEALZ_RS06310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MEALZ_RS06320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MEALZ_RS06325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MEALZ_RS06330	COG0459	protein refolding
MEALZ_RS06360	COG3259	Nickel-dependent hydrogenase
MEALZ_RS06365	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
MEALZ_RS06370	COG3383	formate dehydrogenase (NAD+) activity
MEALZ_RS06375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MEALZ_RS06410	COG1032	radical SAM domain protein
MEALZ_RS06450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MEALZ_RS06465	COG2409	Drug exporters of the RND superfamily
MEALZ_RS06485	COG0659	secondary active sulfate transmembrane transporter activity
MEALZ_RS06490	COG0589	response to stress
MEALZ_RS06505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MEALZ_RS06510	COG1192	Involved in chromosome partitioning
MEALZ_RS06520	COG2062	phosphohistidine phosphatase, SixA
MEALZ_RS06535	COG0581	inorganic phosphate transmembrane transporter activity
MEALZ_RS06540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MEALZ_RS06550	COG0704	Plays a role in the regulation of phosphate uptake
MEALZ_RS06560	COG0519	Catalyzes the synthesis of GMP from XMP
MEALZ_RS06595	COG1518	maintenance of DNA repeat elements
MEALZ_RS06600	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MEALZ_RS06605	COG1376	ErfK ybiS ycfS ynhG family protein
MEALZ_RS06625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MEALZ_RS06630	COG0508	dehydrogenase complex catalyzes the overall conversion of
MEALZ_RS06635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MEALZ_RS06640	COG0372	Belongs to the citrate synthase family
MEALZ_RS06645	COG0800	Aldolase
MEALZ_RS06650	COG0129	dihydroxy-acid dehydratase activity
MEALZ_RS06680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MEALZ_RS06685	COG2197	response regulator
MEALZ_RS06690	COG0702	epimerase
MEALZ_RS06695	COG0702	epimerase
MEALZ_RS06705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MEALZ_RS06720	COG1639	'signal transduction protein
MEALZ_RS06725	COG5001	Diguanylate cyclase
MEALZ_RS06725	COG5002	protein histidine kinase activity
MEALZ_RS06730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MEALZ_RS06750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MEALZ_RS06755	COG2226	methyltransferase
MEALZ_RS06770	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MEALZ_RS06785	COG3549	Plasmid maintenance system killer
MEALZ_RS06875	COG0557	exoribonuclease II activity
MEALZ_RS06880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MEALZ_RS06900	COG0739	heme binding
MEALZ_RS06900	COG0741	lytic transglycosylase activity
MEALZ_RS06900	COG1196	nuclear chromosome segregation
MEALZ_RS06905	COG1607	acyl-coa hydrolase
MEALZ_RS06915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MEALZ_RS06920	COG2204	response regulator
MEALZ_RS06925	COG4191	Histidine kinase
MEALZ_RS06955	COG0489	protein tyrosine kinase activity
MEALZ_RS06980	COG1253	flavin adenine dinucleotide binding
MEALZ_RS06985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MEALZ_RS06990	COG3608	succinylglutamate desuccinylase aspartoacylase
MEALZ_RS06990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MEALZ_RS07005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MEALZ_RS07010	COG2080	2 iron, 2 sulfur cluster binding
MEALZ_RS07015	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MEALZ_RS07020	COG0668	transmembrane transport
MEALZ_RS07045	COG5012	cobalamin binding
MEALZ_RS07060	COG0784	Response regulator, receiver
MEALZ_RS07060	COG2205	protein histidine kinase activity
MEALZ_RS07060	COG5002	protein histidine kinase activity
MEALZ_RS07070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MEALZ_RS07070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MEALZ_RS07075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MEALZ_RS07090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MEALZ_RS07100	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS07125	COG0037	tRNA processing
MEALZ_RS07130	COG0504	CTP synthase activity
MEALZ_RS07135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MEALZ_RS07140	COG0148	phosphopyruvate hydratase activity
MEALZ_RS07145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MEALZ_RS07150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MEALZ_RS07155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MEALZ_RS07160	COG0585	pseudouridine synthase activity
MEALZ_RS07165	COG1968	undecaprenyl-diphosphatase activity
MEALZ_RS07175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MEALZ_RS07180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MEALZ_RS07185	COG1238	metal cluster binding
MEALZ_RS07190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MEALZ_RS07205	COG0513	Belongs to the DEAD box helicase family
MEALZ_RS07235	COG0135	phosphoribosylanthranilate isomerase activity
MEALZ_RS07240	COG0133	tryptophan synthase activity
MEALZ_RS07245	COG0159	tryptophan synthase activity
MEALZ_RS07250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MEALZ_RS07255	COG0285	dihydrofolate synthase activity
MEALZ_RS07290	COG2151	metal-sulfur cluster biosynthetic enzyme
MEALZ_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS07305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MEALZ_RS07310	COG0402	S-adenosylhomocysteine deaminase activity
MEALZ_RS07315	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MEALZ_RS07335	COG0366	Alpha amylase catalytic
MEALZ_RS07335	COG1874	Beta-galactosidase
MEALZ_RS07340	COG0473	3-isopropylmalate dehydrogenase activity
MEALZ_RS07355	COG3385	transposase activity
MEALZ_RS07360	COG0784	Response regulator, receiver
MEALZ_RS07360	COG5002	protein histidine kinase activity
MEALZ_RS07360	COG2205	protein histidine kinase activity
MEALZ_RS07365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MEALZ_RS07365	COG1648	precorrin-2 dehydrogenase activity
MEALZ_RS07400	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MEALZ_RS07430	COG0318	PFAM AMP-dependent synthetase and ligase
MEALZ_RS07435	COG3385	transposase activity
MEALZ_RS07510	COG3712	iron ion homeostasis
MEALZ_RS07525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MEALZ_RS07565	COG2890	protein-(glutamine-N5) methyltransferase activity
MEALZ_RS07570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MEALZ_RS07580	COG0811	peptide transport
MEALZ_RS07585	COG0848	biopolymer transport protein
MEALZ_RS07590	COG1663	tetraacyldisaccharide 4'-kinase activity
MEALZ_RS07595	COG2835	tetraacyldisaccharide 4'-kinase activity
MEALZ_RS07605	COG0436	Aminotransferase
MEALZ_RS07615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MEALZ_RS07630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MEALZ_RS07630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MEALZ_RS07635	COG0802	atpase or kinase
MEALZ_RS07640	COG0860	N-Acetylmuramoyl-L-alanine amidase
MEALZ_RS07650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MEALZ_RS07655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MEALZ_RS07665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MEALZ_RS07675	COG1739	Uncharacterized protein family UPF0029
MEALZ_RS07685	COG1012	belongs to the aldehyde dehydrogenase family
MEALZ_RS07695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MEALZ_RS07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
MEALZ_RS07720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MEALZ_RS07730	COG1763	Mo-molybdopterin cofactor biosynthetic process
MEALZ_RS07750	COG3153	acetyltransferase
MEALZ_RS07750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MEALZ_RS07765	COG2833	Protein of unknown function (DUF455)
MEALZ_RS07790	COG3264	Mechanosensitive ion channel
MEALZ_RS07790	COG1511	domain protein
MEALZ_RS07820	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS07820	COG0604	alcohol dehydrogenase
MEALZ_RS07820	COG3321	synthase
MEALZ_RS07855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MEALZ_RS07870	COG0471	metal ion transport
MEALZ_RS07875	COG0688	phosphatidylethanolamine metabolic process
MEALZ_RS07885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MEALZ_RS07890	COG1196	nuclear chromosome segregation
MEALZ_RS07905	COG2135	peptidase activity
MEALZ_RS07910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MEALZ_RS07915	COG2890	protein-(glutamine-N5) methyltransferase activity
MEALZ_RS07920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MEALZ_RS07930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MEALZ_RS07965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MEALZ_RS07970	COG3437	response regulator, receiver
MEALZ_RS07975	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS07975	COG2205	protein histidine kinase activity
MEALZ_RS07975	COG4191	Histidine kinase
MEALZ_RS07985	COG0784	Response regulator, receiver
MEALZ_RS07985	COG2198	Histidine kinase
MEALZ_RS07985	COG2205	protein histidine kinase activity
MEALZ_RS07995	COG1131	(ABC) transporter
MEALZ_RS08000	COG2915	High frequency lysogenization protein hflD homolog
MEALZ_RS08010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MEALZ_RS08020	COG2608	mercury ion transmembrane transporter activity
MEALZ_RS08020	COG2217	Heavy metal translocating P-type atpase
MEALZ_RS08030	COG5001	Diguanylate cyclase
MEALZ_RS08030	COG5002	protein histidine kinase activity
MEALZ_RS08040	COG3706	GGDEF domain
MEALZ_RS08055	COG1269	ATP hydrolysis coupled proton transport
MEALZ_RS08075	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MEALZ_RS08080	COG0840	transmembrane signaling receptor activity
MEALZ_RS08085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MEALZ_RS08095	COG0360	Binds together with S18 to 16S ribosomal RNA
MEALZ_RS08100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MEALZ_RS08110	COG0359	binds to the 23S rRNA
MEALZ_RS08120	COG0791	NLP P60 protein
MEALZ_RS08130	COG2132	Multicopper oxidase
MEALZ_RS08160	COG0247	lactate metabolic process
MEALZ_RS08165	COG0277	FAD linked oxidase domain protein
MEALZ_RS08170	COG0277	FAD linked oxidase domain protein
MEALZ_RS08200	COG0668	transmembrane transport
MEALZ_RS08215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MEALZ_RS08240	COG3265	gluconokinase activity
MEALZ_RS08270	COG4251	negative regulation of phosphorylation
MEALZ_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS08290	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS08295	COG0642	Histidine kinase
MEALZ_RS08300	COG0574	Belongs to the PEP-utilizing enzyme family
MEALZ_RS08300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MEALZ_RS08305	COG0123	including yeast histone deacetylase and acetoin utilization protein
MEALZ_RS08310	COG0189	ligase activity
MEALZ_RS08310	COG4067	protein conserved in archaea
MEALZ_RS08315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MEALZ_RS08325	COG1674	ftsk spoiiie
MEALZ_RS08335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MEALZ_RS08370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MEALZ_RS08390	COG0733	neurotransmitter:sodium symporter activity
MEALZ_RS08440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MEALZ_RS08445	COG0700	Nucleoside recognition
MEALZ_RS08455	COG2198	Histidine kinase
MEALZ_RS08455	COG5002	protein histidine kinase activity
MEALZ_RS08455	COG0784	Response regulator, receiver
MEALZ_RS08475	COG3204	pilus organization
MEALZ_RS08485	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS08490	COG0784	Response regulator, receiver
MEALZ_RS08490	COG2198	Histidine kinase
MEALZ_RS08490	COG5002	protein histidine kinase activity
MEALZ_RS08540	COG1598	PFAM Uncharacterised protein family UPF0150
MEALZ_RS08570	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
MEALZ_RS08585	COG2337	Toxic component of a toxin-antitoxin (TA) module
MEALZ_RS08630	COG1172	Belongs to the binding-protein-dependent transport system permease family
MEALZ_RS08650	COG0829	nickel cation binding
MEALZ_RS08655	COG0831	urea catabolic process
MEALZ_RS08660	COG0832	Belongs to the urease beta subunit family
MEALZ_RS08665	COG0804	urea catabolic process
MEALZ_RS08670	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MEALZ_RS08675	COG0830	nickel cation binding
MEALZ_RS08680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MEALZ_RS08685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MEALZ_RS08695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MEALZ_RS08695	COG0047	phosphoribosylformylglycinamidine synthase activity
MEALZ_RS08700	COG0071	Belongs to the small heat shock protein (HSP20) family
MEALZ_RS08705	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MEALZ_RS08775	COG0494	nUDIX hydrolase
MEALZ_RS08780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MEALZ_RS08785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MEALZ_RS08785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MEALZ_RS08790	COG0129	dihydroxy-acid dehydratase activity
MEALZ_RS08800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MEALZ_RS08805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MEALZ_RS08815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MEALZ_RS08825	COG0431	NADPH-dependent FMN reductase
MEALZ_RS08845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MEALZ_RS08855	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MEALZ_RS08865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MEALZ_RS08870	COG0149	triose-phosphate isomerase activity
MEALZ_RS08890	COG1234	tRNA 3'-trailer cleavage
MEALZ_RS08910	COG0583	DNA-binding transcription factor activity
MEALZ_RS08915	COG0242	peptide deformylase activity
MEALZ_RS08925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MEALZ_RS08940	COG2813	Specifically methylates the guanine in position
MEALZ_RS08955	COG0784	Response regulator, receiver
MEALZ_RS08970	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MEALZ_RS08990	COG2154	pterin-4-alpha-carbinolamine dehydratase
MEALZ_RS09000	COG0574	Belongs to the PEP-utilizing enzyme family
MEALZ_RS09000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MEALZ_RS09005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MEALZ_RS09010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MEALZ_RS09020	COG2350	Protein conserved in bacteria
MEALZ_RS09025	COG2917	probably involved in intracellular septation
MEALZ_RS09045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MEALZ_RS09050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MEALZ_RS09080	COG0640	Transcriptional regulator
MEALZ_RS09085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MEALZ_RS09090	COG0798	PFAM Bile acid sodium symporter
MEALZ_RS09105	COG0628	permease
MEALZ_RS09120	COG0469	pyruvate kinase activity
MEALZ_RS09130	COG0573	inorganic phosphate transmembrane transporter activity
MEALZ_RS09135	COG0581	inorganic phosphate transmembrane transporter activity
MEALZ_RS09140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MEALZ_RS09175	COG1846	Transcriptional regulator
MEALZ_RS09185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MEALZ_RS09190	COG2957	Belongs to the agmatine deiminase family
MEALZ_RS09195	COG0497	DNA recombination
MEALZ_RS09200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MEALZ_RS09205	COG1420	regulation of RNA biosynthetic process
MEALZ_RS09210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MEALZ_RS09215	COG0443	Heat shock 70 kDa protein
MEALZ_RS09220	COG0484	heat shock protein binding
MEALZ_RS09225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MEALZ_RS09235	COG3383	formate dehydrogenase (NAD+) activity
MEALZ_RS09260	COG4636	protein conserved in cyanobacteria
MEALZ_RS09275	COG0746	molybdenum cofactor guanylyltransferase activity
MEALZ_RS09280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MEALZ_RS09290	COG0501	Belongs to the peptidase M48B family
MEALZ_RS09300	COG0494	nUDIX hydrolase
MEALZ_RS09310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MEALZ_RS09325	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS09330	COG0367	asparagine synthase
MEALZ_RS09360	COG1295	ribonuclease BN
MEALZ_RS09360	COG1959	2 iron, 2 sulfur cluster binding
MEALZ_RS09365	COG2205	protein histidine kinase activity
MEALZ_RS09365	COG0784	Response regulator, receiver
MEALZ_RS09380	COG0442	prolyl-tRNA aminoacylation
MEALZ_RS09400	COG2814	Major facilitator Superfamily
MEALZ_RS09405	COG0629	single-stranded DNA binding
MEALZ_RS09410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MEALZ_RS09425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MEALZ_RS09425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MEALZ_RS09430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MEALZ_RS09445	COG1376	ErfK ybiS ycfS ynhG family protein
MEALZ_RS09600	COG2801	Transposase and inactivated derivatives
MEALZ_RS09610	COG4636	protein conserved in cyanobacteria
MEALZ_RS09625	COG2815	serine threonine protein kinase
MEALZ_RS09625	COG0515	serine threonine protein kinase
MEALZ_RS09635	COG2205	protein histidine kinase activity
MEALZ_RS09650	COG0375	protein maturation
MEALZ_RS09670	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS09675	COG0659	secondary active sulfate transmembrane transporter activity
MEALZ_RS09685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MEALZ_RS09690	COG0409	Hydrogenase expression formation protein
MEALZ_RS09710	COG1104	cysteine desulfurase activity
MEALZ_RS09715	COG2129	metallophosphoesterase
MEALZ_RS09735	COG1643	Atp-dependent helicase
MEALZ_RS09745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MEALZ_RS09750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MEALZ_RS09765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MEALZ_RS09770	COG0733	neurotransmitter:sodium symporter activity
MEALZ_RS09780	COG2914	Belongs to the UPF0125 (RnfH) family
MEALZ_RS09785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MEALZ_RS09790	COG0735	belongs to the Fur family
MEALZ_RS09795	COG4591	ABC-type transport system involved in lipoprotein release permease component
MEALZ_RS09800	COG1136	(ABC) transporter
MEALZ_RS09815	COG1959	2 iron, 2 sulfur cluster binding
MEALZ_RS09820	COG0719	Fe-S assembly protein
MEALZ_RS09835	COG0396	ATPase activity
MEALZ_RS09840	COG0719	Fe-S assembly protein
MEALZ_RS09850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MEALZ_RS09855	COG0822	iron-sulfur transferase activity
MEALZ_RS09860	COG0742	ribosomal rna small subunit methyltransferase
MEALZ_RS09875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MEALZ_RS09905	COG5001	Diguanylate cyclase
MEALZ_RS09905	COG5002	protein histidine kinase activity
MEALZ_RS09920	COG0084	hydrolase, TatD family'
MEALZ_RS09935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MEALZ_RS09940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MEALZ_RS09950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MEALZ_RS09955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEALZ_RS09970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MEALZ_RS09975	COG0416	fatty acid biosynthetic process
MEALZ_RS09980	COG1399	metal-binding, possibly nucleic acid-binding protein
MEALZ_RS09985	COG0424	maF-like protein
MEALZ_RS09995	COG0741	lytic transglycosylase activity
MEALZ_RS10000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MEALZ_RS10010	COG0302	gtp cyclohydrolase
MEALZ_RS10015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MEALZ_RS10020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MEALZ_RS10040	COG3267	Type II secretory pathway component ExeA
MEALZ_RS10040	COG3409	Peptidoglycan-binding domain 1 protein
MEALZ_RS10070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MEALZ_RS10080	COG0405	Gamma-glutamyltransferase
MEALZ_RS10095	COG0835	chemotaxis
MEALZ_RS10100	COG0840	transmembrane signaling receptor activity
MEALZ_RS10120	COG2197	response regulator
MEALZ_RS10130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MEALZ_RS10155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MEALZ_RS10165	COG3177	Filamentation induced by cAMP protein fic
MEALZ_RS10175	COG2852	Protein conserved in bacteria
MEALZ_RS10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MEALZ_RS10365	COG3385	transposase activity
MEALZ_RS10370	COG0515	serine threonine protein kinase
MEALZ_RS10370	COG3266	domain, Protein
MEALZ_RS10450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MEALZ_RS10465	COG0582	viral genome integration into host DNA
MEALZ_RS10520	COG1538	Outer membrane efflux protein
MEALZ_RS10550	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MEALZ_RS10555	COG1518	maintenance of DNA repeat elements
MEALZ_RS10585	COG3344	reverse transcriptase
MEALZ_RS10695	COG2719	SpoVR family
MEALZ_RS10700	COG2718	Belongs to the UPF0229 family
MEALZ_RS10705	COG2766	serine protein kinase
MEALZ_RS10735	COG0741	lytic transglycosylase activity
MEALZ_RS10765	COG3012	SEC-C Motif Domain Protein
MEALZ_RS10765	COG3318	Belongs to the UPF0149 family
MEALZ_RS10770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MEALZ_RS10775	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MEALZ_RS10785	COG2010	Cytochrome c
MEALZ_RS10785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MEALZ_RS10795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MEALZ_RS10800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MEALZ_RS10805	COG0735	belongs to the Fur family
MEALZ_RS10850	COG1366	Belongs to the anti-sigma-factor antagonist family
MEALZ_RS10860	COG0791	NLP P60 protein
MEALZ_RS10875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MEALZ_RS10890	COG3174	membrane
MEALZ_RS10920	COG2925	Exonuclease
MEALZ_RS10925	COG0617	tRNA 3'-terminal CCA addition
MEALZ_RS10925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MEALZ_RS10925	COG0517	IMP dehydrogenase activity
MEALZ_RS10935	COG1477	protein flavinylation
MEALZ_RS10940	COG2871	sodium ion transport
MEALZ_RS10945	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MEALZ_RS10950	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MEALZ_RS10955	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MEALZ_RS10960	COG1805	sodium ion transport
MEALZ_RS10970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MEALZ_RS10975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MEALZ_RS10985	COG0418	dihydroorotase activity
MEALZ_RS11010	COG0101	tRNA pseudouridine synthase activity
MEALZ_RS11020	COG3012	SEC-C Motif Domain Protein
MEALZ_RS11025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MEALZ_RS11045	COG4251	negative regulation of phosphorylation
MEALZ_RS11055	COG3706	GGDEF domain
MEALZ_RS11070	COG1858	cytochrome C peroxidase
MEALZ_RS11075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MEALZ_RS11080	COG1131	(ABC) transporter
MEALZ_RS11095	COG0405	Gamma-glutamyltransferase
MEALZ_RS11150	COG0396	ATPase activity
MEALZ_RS11165	COG0446	pyridine nucleotide-disulphide oxidoreductase
MEALZ_RS11170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MEALZ_RS11175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MEALZ_RS11180	COG1116	anion transmembrane transporter activity
MEALZ_RS11190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MEALZ_RS11195	COG0243	molybdopterin cofactor binding
MEALZ_RS11210	COG0210	DNA helicase
MEALZ_RS11225	COG1324	tolerance protein
MEALZ_RS11230	COG4232	protein-disulfide reductase activity
MEALZ_RS11235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MEALZ_RS11240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MEALZ_RS11245	COG0511	ligase activity, forming carbon-carbon bonds
MEALZ_RS11250	COG0439	Biotin carboxylase
MEALZ_RS11255	COG2264	protein methyltransferase activity
MEALZ_RS11280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MEALZ_RS11290	COG0138	bifunctional purine biosynthesis protein purh
MEALZ_RS11295	COG0151	Belongs to the GarS family
MEALZ_RS11300	COG2177	Part of the ABC transporter FtsEX involved in
MEALZ_RS11305	COG2884	Cell division ATP-binding protein ftsE
MEALZ_RS11310	COG0552	protein localization to endoplasmic reticulum
MEALZ_RS11335	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MEALZ_RS11340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MEALZ_RS11345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MEALZ_RS11350	COG2703	oxygen carrier activity
MEALZ_RS11355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MEALZ_RS11360	COG2226	methyltransferase
MEALZ_RS11365	COG2267	carboxylic ester hydrolase activity
MEALZ_RS11370	COG0156	8-amino-7-oxononanoate synthase activity
MEALZ_RS11375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MEALZ_RS11380	COG1040	competence protein
MEALZ_RS11410	COG1131	(ABC) transporter
MEALZ_RS11475	COG0439	Biotin carboxylase
MEALZ_RS11480	COG0511	ligase activity, forming carbon-carbon bonds
MEALZ_RS11480	COG5016	pyruvate
MEALZ_RS11485	COG0009	L-threonylcarbamoyladenylate synthase
MEALZ_RS11490	COG0280	phosphate acetyltransferase
MEALZ_RS11490	COG0857	belongs to the CobB CobQ family
MEALZ_RS11495	COG1538	Outer membrane efflux protein
MEALZ_RS11630	COG3585	molybdate ion transport
MEALZ_RS11630	COG2005	Transcriptional regulator
MEALZ_RS11650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MEALZ_RS11655	COG3956	TIGRFAM MazG family protein
MEALZ_RS11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEALZ_RS11665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MEALZ_RS11670	COG0509	glycine decarboxylation via glycine cleavage system
MEALZ_RS11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MEALZ_RS11690	COG2205	protein histidine kinase activity
MEALZ_RS11695	COG3437	response regulator, receiver
MEALZ_RS11735	COG2985	domain, Protein
MEALZ_RS11740	COG0501	Belongs to the peptidase M48B family
MEALZ_RS11745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MEALZ_RS11750	COG0084	hydrolase, TatD family'
MEALZ_RS11755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MEALZ_RS11760	COG0537	adenosine 5'-monophosphoramidase activity
MEALZ_RS11765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MEALZ_RS11770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MEALZ_RS11775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MEALZ_RS11790	COG2197	response regulator
MEALZ_RS11795	COG1309	transcriptional regulator
MEALZ_RS11830	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS11835	COG0288	reversible hydration of carbon dioxide
MEALZ_RS11840	COG0659	secondary active sulfate transmembrane transporter activity
MEALZ_RS11845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MEALZ_RS11855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MEALZ_RS11860	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MEALZ_RS11865	COG0189	ligase activity
MEALZ_RS11875	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MEALZ_RS11880	COG3385	transposase activity
MEALZ_RS11890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MEALZ_RS11910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MEALZ_RS11915	COG0305	Participates in initiation and elongation during chromosome replication
MEALZ_RS11965	COG1067	ATP-dependent peptidase activity
MEALZ_RS12005	COG3437	response regulator, receiver
MEALZ_RS12010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MEALZ_RS12015	COG0156	8-amino-7-oxononanoate synthase activity
MEALZ_RS12030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MEALZ_RS12030	COG3064	Membrane
MEALZ_RS12030	COG1073	alpha beta
MEALZ_RS12045	COG0840	transmembrane signaling receptor activity
MEALZ_RS12085	COG0235	Class ii aldolase
MEALZ_RS12090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MEALZ_RS12095	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
MEALZ_RS12120	COG2095	MarC family integral membrane protein
MEALZ_RS12130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MEALZ_RS12135	COG0569	domain protein
MEALZ_RS12145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MEALZ_RS12150	COG0569	domain protein
MEALZ_RS12190	COG0776	regulation of translation
MEALZ_RS12200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MEALZ_RS12205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MEALZ_RS12210	COG0287	Prephenate dehydrogenase
MEALZ_RS12225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MEALZ_RS12270	COG1138	Cytochrome C-type biogenesis protein
MEALZ_RS12275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MEALZ_RS12280	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MEALZ_RS12295	COG4133	protoheme IX ABC transporter activity
MEALZ_RS12305	COG3459	Glycosyltransferase 36 associated
MEALZ_RS12325	COG0726	polysaccharide deacetylase
MEALZ_RS12355	COG1657	PFAM Prenyltransferase squalene oxidase
MEALZ_RS12435	COG0058	SHG alpha-glucan phosphorylase activity
MEALZ_RS12455	COG2823	Periplasmic or secreted lipoprotein
MEALZ_RS12545	COG3706	GGDEF domain
MEALZ_RS12550	COG0753	catalase activity
MEALZ_RS12580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MEALZ_RS12585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MEALZ_RS12610	COG3237	CsbD-like
MEALZ_RS12625	COG2823	Periplasmic or secreted lipoprotein
MEALZ_RS12660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MEALZ_RS12665	COG0542	response to heat
MEALZ_RS12670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MEALZ_RS12680	COG0482	sulfurtransferase activity
MEALZ_RS12690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MEALZ_RS12725	COG1160	GTP binding
MEALZ_RS12750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MEALZ_RS12755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MEALZ_RS12800	COG0037	tRNA processing
MEALZ_RS12810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MEALZ_RS12815	COG0741	lytic transglycosylase activity
MEALZ_RS12820	COG1132	(ABC) transporter
MEALZ_RS12825	COG0613	PHP domain protein
MEALZ_RS12840	COG2983	Belongs to the UPF0260 family
MEALZ_RS12845	COG0708	Exodeoxyribonuclease III
MEALZ_RS12850	COG1573	uracil-dna glycosylase
MEALZ_RS12880	COG0425	Belongs to the sulfur carrier protein TusA family
MEALZ_RS12885	COG1648	precorrin-2 dehydrogenase activity
MEALZ_RS12885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MEALZ_RS12905	COG0137	argininosuccinate synthase activity
MEALZ_RS12910	COG2827	Endonuclease containing a URI domain
MEALZ_RS12930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MEALZ_RS12935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MEALZ_RS12940	COG3437	response regulator, receiver
MEALZ_RS12955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MEALZ_RS12960	COG0784	Response regulator, receiver
MEALZ_RS12960	COG2198	Histidine kinase
MEALZ_RS12960	COG5002	protein histidine kinase activity
MEALZ_RS12985	COG5001	Diguanylate cyclase
MEALZ_RS12985	COG5002	protein histidine kinase activity
MEALZ_RS12990	COG1362	aminopeptidase activity
MEALZ_RS12995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MEALZ_RS13000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MEALZ_RS13005	COG3630	sodium ion export across plasma membrane
MEALZ_RS13020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MEALZ_RS13025	COG0842	Transport permease protein
MEALZ_RS13030	COG1131	(ABC) transporter
MEALZ_RS13045	COG1858	cytochrome C peroxidase
MEALZ_RS13050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MEALZ_RS13065	COG0789	Transcriptional regulator
MEALZ_RS13075	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MEALZ_RS13085	COG1053	succinate dehydrogenase
MEALZ_RS13090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MEALZ_RS13115	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS13125	COG1215	transferase activity, transferring glycosyl groups
MEALZ_RS13180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MEALZ_RS13195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MEALZ_RS13210	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS13220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MEALZ_RS13240	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS13260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEALZ_RS13275	COG2244	polysaccharide biosynthetic process
MEALZ_RS13315	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS13340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MEALZ_RS13365	COG0463	Glycosyl transferase, family 2
MEALZ_RS13370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MEALZ_RS13380	COG4636	protein conserved in cyanobacteria
MEALZ_RS13385	COG1368	sulfuric ester hydrolase activity
MEALZ_RS13390	COG0419	ATPase involved in DNA repair
MEALZ_RS13395	COG0420	3'-5' exonuclease activity
MEALZ_RS13405	COG2204	response regulator
MEALZ_RS13415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MEALZ_RS13430	COG0529	Catalyzes the synthesis of activated sulfate
MEALZ_RS13435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MEALZ_RS13440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MEALZ_RS13470	COG2239	Acts as a magnesium transporter
MEALZ_RS13480	COG0316	Belongs to the HesB IscA family
MEALZ_RS13485	COG1104	cysteine desulfurase activity
MEALZ_RS13490	COG1959	2 iron, 2 sulfur cluster binding
MEALZ_RS13500	COG1045	serine acetyltransferase
MEALZ_RS13515	COG3385	transposase activity
MEALZ_RS13525	COG0330	HflC and HflK could
MEALZ_RS13540	COG3568	Endonuclease Exonuclease Phosphatase
MEALZ_RS13555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MEALZ_RS13560	COG0514	ATP-dependent DNA helicase (RecQ)
MEALZ_RS13585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MEALZ_RS13590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MEALZ_RS13600	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MEALZ_RS13625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MEALZ_RS13640	COG3385	transposase activity
MEALZ_RS13715	COG1598	PFAM Uncharacterised protein family UPF0150
MEALZ_RS13735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MEALZ_RS13740	COG0419	ATPase involved in DNA repair
MEALZ_RS13745	COG0318	PFAM AMP-dependent synthetase and ligase
MEALZ_RS13745	COG0204	Acyl-transferase
MEALZ_RS13755	COG1858	cytochrome C peroxidase
MEALZ_RS13760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MEALZ_RS13785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MEALZ_RS13825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MEALZ_RS13835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MEALZ_RS13840	COG2137	regulation of response to DNA damage stimulus
MEALZ_RS13845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MEALZ_RS13860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MEALZ_RS13870	COG0673	inositol 2-dehydrogenase activity
MEALZ_RS13875	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MEALZ_RS13880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MEALZ_RS13885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MEALZ_RS13890	COG0730	response to heat
MEALZ_RS13900	COG0366	Alpha amylase catalytic
MEALZ_RS13905	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MEALZ_RS13910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MEALZ_RS13915	COG0436	Aminotransferase
MEALZ_RS13925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MEALZ_RS13930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MEALZ_RS13935	COG0175	sulfate reduction
MEALZ_RS13960	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS13965	COG2198	Histidine kinase
MEALZ_RS13965	COG0643	Histidine kinase
MEALZ_RS13975	COG0840	transmembrane signaling receptor activity
MEALZ_RS13975	COG0840	transmembrane signaling receptor activity
MEALZ_RS13980	COG0835	chemotaxis
MEALZ_RS13995	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MEALZ_RS14000	COG2201	protein-glutamate methylesterase activity
MEALZ_RS14005	COG0840	transmembrane signaling receptor activity
MEALZ_RS14060	COG5002	protein histidine kinase activity
MEALZ_RS14070	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS14085	COG0583	DNA-binding transcription factor activity
MEALZ_RS14090	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MEALZ_RS14110	COG3273	potassium ion transport
MEALZ_RS14110	COG0471	metal ion transport
MEALZ_RS14135	COG2091	lysine biosynthetic process via aminoadipic acid
MEALZ_RS14145	COG2084	Dehydrogenase
MEALZ_RS14150	COG3622	Belongs to the hyi family
MEALZ_RS14160	COG3290	protein histidine kinase activity
MEALZ_RS14170	COG4251	negative regulation of phosphorylation
MEALZ_RS14190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MEALZ_RS14195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MEALZ_RS14200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MEALZ_RS14205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MEALZ_RS14220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MEALZ_RS14220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MEALZ_RS14225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MEALZ_RS14230	COG1450	Type ii and iii secretion system protein
MEALZ_RS14260	COG2165	general secretion pathway protein
MEALZ_RS14280	COG1459	type II secretion system
MEALZ_RS14285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MEALZ_RS14320	COG0840	transmembrane signaling receptor activity
MEALZ_RS14325	COG0835	chemotaxis
MEALZ_RS14330	COG0643	Histidine kinase
MEALZ_RS14330	COG2198	Histidine kinase
MEALZ_RS14360	COG0631	protein serine/threonine phosphatase activity
MEALZ_RS14385	COG1122	ATPase activity
MEALZ_RS14395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MEALZ_RS14405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MEALZ_RS14410	COG0575	Belongs to the CDS family
MEALZ_RS14415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MEALZ_RS14420	COG0233	cytoplasmic translational termination
MEALZ_RS14425	COG0528	UMP kinase activity
MEALZ_RS14430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MEALZ_RS14435	COG0052	Belongs to the universal ribosomal protein uS2 family
MEALZ_RS14445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MEALZ_RS14460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MEALZ_RS14465	COG0070	glutamate synthase
MEALZ_RS14465	COG0069	glutamate synthase activity
MEALZ_RS14465	COG0067	glutamate synthase
MEALZ_RS14470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MEALZ_RS14485	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MEALZ_RS14490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MEALZ_RS14560	COG0811	peptide transport
MEALZ_RS14570	COG2831	hemolysin activation secretion protein
MEALZ_RS14615	COG0542	response to heat
MEALZ_RS14640	COG5433	transposase activity
MEALZ_RS14670	COG1278	Cold shock
MEALZ_RS14700	COG1278	Cold shock
MEALZ_RS14715	COG1136	(ABC) transporter
MEALZ_RS14740	COG0848	biopolymer transport protein
MEALZ_RS14745	COG0811	peptide transport
MEALZ_RS14750	COG0811	peptide transport
MEALZ_RS14765	COG0372	Belongs to the citrate synthase family
MEALZ_RS14770	COG1049	propionate catabolic process, 2-methylcitrate cycle
MEALZ_RS14775	COG0473	3-isopropylmalate dehydrogenase activity
MEALZ_RS14785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MEALZ_RS14790	COG0429	hydrolase of the alpha beta-hydrolase fold
MEALZ_RS14810	COG0400	carboxylic ester hydrolase activity
MEALZ_RS14825	COG0328	RNA-DNA hybrid ribonuclease activity
MEALZ_RS14835	COG0741	lytic transglycosylase activity
MEALZ_RS14835	COG1388	LysM domain
MEALZ_RS14845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MEALZ_RS14850	COG0601	transmembrane transport
MEALZ_RS14865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MEALZ_RS14880	COG0776	regulation of translation
MEALZ_RS14885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MEALZ_RS14890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MEALZ_RS14895	COG0740	serine-type endopeptidase activity
MEALZ_RS14900	COG0544	peptidyl-prolyl cis-trans isomerase activity
MEALZ_RS14930	COG2814	Major facilitator Superfamily
MEALZ_RS14935	COG1538	Outer membrane efflux protein
MEALZ_RS14940	COG1566	PFAM secretion protein HlyD family protein
MEALZ_RS14945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MEALZ_RS14950	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MEALZ_RS14955	COG0330	HflC and HflK could
MEALZ_RS14960	COG0330	HflC and HflK could
MEALZ_RS14965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MEALZ_RS14970	COG1923	regulation of RNA biosynthetic process
MEALZ_RS14980	COG0596	Alpha beta hydrolase
MEALZ_RS14990	COG2081	HI0933 family
MEALZ_RS15005	COG1519	Transferase
MEALZ_RS15025	COG1587	Uroporphyrinogen-III synthase
MEALZ_RS15030	COG0181	hydroxymethylbilane synthase activity
MEALZ_RS15035	COG0165	Argininosuccinate lyase
MEALZ_RS15040	COG3072	Adenylate cyclase
MEALZ_RS15050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MEALZ_RS15055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MEALZ_RS15060	COG0469	pyruvate kinase activity
MEALZ_RS15070	COG2202	Pas domain
MEALZ_RS15070	COG1366	Belongs to the anti-sigma-factor antagonist family
MEALZ_RS15080	COG2202	Pas domain
MEALZ_RS15080	COG1366	Belongs to the anti-sigma-factor antagonist family
MEALZ_RS15095	COG1722	exodeoxyribonuclease VII activity
MEALZ_RS15100	COG0142	geranyltranstransferase activity
MEALZ_RS15105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MEALZ_RS15110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MEALZ_RS15115	COG2853	Lipoprotein
MEALZ_RS15135	COG1657	PFAM Prenyltransferase squalene oxidase
MEALZ_RS15145	COG2409	Drug exporters of the RND superfamily
MEALZ_RS15170	COG0670	Belongs to the BI1 family
MEALZ_RS15180	COG0193	aminoacyl-tRNA hydrolase activity
MEALZ_RS15185	COG4536	flavin adenine dinucleotide binding
MEALZ_RS15200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MEALZ_RS15215	COG0616	signal peptide processing
MEALZ_RS15225	COG0564	pseudouridine synthase activity
MEALZ_RS15230	COG1530	ribonuclease E activity
MEALZ_RS15245	COG0587	DNA-directed DNA polymerase activity
MEALZ_RS15255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MEALZ_RS15260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MEALZ_RS15275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MEALZ_RS15280	COG1403	HNH endonuclease
MEALZ_RS15290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MEALZ_RS15305	COG0840	transmembrane signaling receptor activity
MEALZ_RS15315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MEALZ_RS15320	COG2201	protein-glutamate methylesterase activity
MEALZ_RS15325	COG0742	ribosomal rna small subunit methyltransferase
MEALZ_RS15330	COG0612	Peptidase, M16
MEALZ_RS15335	COG0612	Peptidase, M16
MEALZ_RS15340	COG0109	protoheme IX farnesyltransferase activity
MEALZ_RS15370	COG0835	chemotaxis
MEALZ_RS15380	COG1192	Involved in chromosome partitioning
MEALZ_RS15385	COG1360	Flagellar Motor Protein
MEALZ_RS15390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MEALZ_RS15395	COG2201	protein-glutamate methylesterase activity
MEALZ_RS15400	COG2198	Histidine kinase
MEALZ_RS15400	COG0643	Histidine kinase
MEALZ_RS15400	COG0784	Response regulator, receiver
MEALZ_RS15405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MEALZ_RS15435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MEALZ_RS15445	COG1684	flagellar biosynthetic protein fliR
MEALZ_RS15480	COG3706	GGDEF domain
MEALZ_RS15480	COG2203	Gaf domain
MEALZ_RS15480	COG4251	negative regulation of phosphorylation
MEALZ_RS15480	COG5001	Diguanylate cyclase
MEALZ_RS15520	COG4964	Belongs to the GSP D family
MEALZ_RS15545	COG1115	amino acid carrier protein
MEALZ_RS15555	COG1278	Cold shock
MEALZ_RS15580	COG0189	ligase activity
MEALZ_RS15580	COG4067	protein conserved in archaea
MEALZ_RS15590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MEALZ_RS15600	COG1994	Peptidase M50
MEALZ_RS15605	COG0009	L-threonylcarbamoyladenylate synthase
MEALZ_RS15610	COG1214	PFAM Peptidase M22, glycoprotease
MEALZ_RS15615	COG1199	ATP-dependent helicase activity
MEALZ_RS15620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MEALZ_RS15625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MEALZ_RS15635	COG2854	intermembrane phospholipid transfer
MEALZ_RS15645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MEALZ_RS15650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MEALZ_RS15670	COG4783	chaperone-mediated protein folding
MEALZ_RS15675	COG2133	pyrroloquinoline quinone binding
MEALZ_RS15690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MEALZ_RS15695	COG0045	succinate-CoA ligase (ADP-forming) activity
MEALZ_RS15710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MEALZ_RS15720	COG0039	L-malate dehydrogenase activity
MEALZ_RS15725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MEALZ_RS15735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MEALZ_RS15740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MEALZ_RS15750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MEALZ_RS15770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MEALZ_RS15775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MEALZ_RS15785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MEALZ_RS15790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MEALZ_RS15835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MEALZ_RS15845	COG5285	phytanoyl-CoA dioxygenase
MEALZ_RS15850	COG0527	aspartate kinase activity
MEALZ_RS15855	COG1917	Cupin 2, conserved barrel domain protein
MEALZ_RS15860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MEALZ_RS15895	COG0659	secondary active sulfate transmembrane transporter activity
MEALZ_RS15900	COG0583	DNA-binding transcription factor activity
MEALZ_RS15905	COG2226	methyltransferase
MEALZ_RS15985	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MEALZ_RS16005	COG4969	Belongs to the N-Me-Phe pilin family
MEALZ_RS16010	COG5433	transposase activity
MEALZ_RS16040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MEALZ_RS16045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MEALZ_RS16055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MEALZ_RS16060	COG0045	succinate-CoA ligase (ADP-forming) activity
MEALZ_RS16080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MEALZ_RS16085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MEALZ_RS16090	COG0006	proline dipeptidase activity
MEALZ_RS16095	COG3079	Belongs to the UPF0149 family
MEALZ_RS16140	COG1598	PFAM Uncharacterised protein family UPF0150
MEALZ_RS16165	COG0456	acetyltransferase
MEALZ_RS16170	COG1573	uracil-dna glycosylase
MEALZ_RS16175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MEALZ_RS16180	COG1183	phosphatidylcholine synthase activity
MEALZ_RS16185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MEALZ_RS16195	COG0028	Belongs to the TPP enzyme family
MEALZ_RS16210	COG0314	molybdopterin synthase activity
MEALZ_RS16215	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MEALZ_RS16220	COG0315	cyclic pyranopterin monophosphate synthase activity
MEALZ_RS16230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MEALZ_RS16235	COG2954	triphosphatase activity
MEALZ_RS16245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MEALZ_RS16250	COG0203	ribosomal protein L17
MEALZ_RS16255	COG0202	RNA polymerase activity
MEALZ_RS16260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MEALZ_RS16265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MEALZ_RS16270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MEALZ_RS16275	COG0201	protein transport
MEALZ_RS16280	COG0200	Binds to the 23S rRNA
MEALZ_RS16285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MEALZ_RS16295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MEALZ_RS16300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MEALZ_RS16310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MEALZ_RS16315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MEALZ_RS16320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MEALZ_RS16325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MEALZ_RS16330	COG0255	Belongs to the universal ribosomal protein uL29 family
MEALZ_RS16335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MEALZ_RS16340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MEALZ_RS16345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MEALZ_RS16350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MEALZ_RS16355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MEALZ_RS16360	COG0089	rRNA binding
MEALZ_RS16365	COG0088	Forms part of the polypeptide exit tunnel
MEALZ_RS16370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MEALZ_RS16375	COG0051	transcription antitermination factor activity, RNA binding
MEALZ_RS16380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MEALZ_RS16385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MEALZ_RS16390	COG0049	tRNA binding
MEALZ_RS16400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MEALZ_RS16405	COG0085	RNA polymerase activity
MEALZ_RS16410	COG0222	ribosome binding
MEALZ_RS16415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MEALZ_RS16425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MEALZ_RS16430	COG0250	Participates in transcription elongation, termination and antitermination
MEALZ_RS16445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MEALZ_RS16465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MEALZ_RS16470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MEALZ_RS16480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MEALZ_RS16495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MEALZ_RS16500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MEALZ_RS16505	COG2890	protein-(glutamine-N5) methyltransferase activity
MEALZ_RS16515	COG4636	protein conserved in cyanobacteria
MEALZ_RS16520	COG4636	protein conserved in cyanobacteria
MEALZ_RS16525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MEALZ_RS16535	COG0154	amidase activity
MEALZ_RS16540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MEALZ_RS16550	COG1077	Cell shape determining protein MreB Mrl
MEALZ_RS16555	COG1792	Involved in formation and maintenance of cell shape
MEALZ_RS16560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MEALZ_RS16565	COG0768	penicillin binding
MEALZ_RS16570	COG0772	Belongs to the SEDS family
MEALZ_RS16575	COG2951	lytic endotransglycosylase activity
MEALZ_RS16580	COG1686	Belongs to the peptidase S11 family
MEALZ_RS16590	COG2921	Belongs to the UPF0250 family
MEALZ_RS16595	COG0321	lipoyl(octanoyl) transferase activity
MEALZ_RS16600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MEALZ_RS16605	COG2183	response to ionizing radiation
MEALZ_RS16615	COG0737	Belongs to the 5'-nucleotidase family
MEALZ_RS16620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MEALZ_RS16630	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MEALZ_RS16640	COG0495	leucyl-tRNA aminoacylation
MEALZ_RS16650	COG1466	dna polymerase III delta subunit
MEALZ_RS16660	COG2204	response regulator
MEALZ_RS16665	COG0326	Molecular chaperone. Has ATPase activity
MEALZ_RS16680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MEALZ_RS16685	COG1166	arginine decarboxylase activity
MEALZ_RS16690	COG2084	Dehydrogenase
MEALZ_RS16705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MEALZ_RS16710	COG0590	tRNA wobble adenosine to inosine editing
MEALZ_RS16725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MEALZ_RS16745	COG2824	Alkylphosphonate utilization operon protein PhnA
MEALZ_RS16755	COG2922	Belongs to the Smg family
MEALZ_RS16760	COG0758	DNA mediated transformation
MEALZ_RS16765	COG1652	LysM domain
MEALZ_RS16770	COG0242	peptide deformylase activity
MEALZ_RS16775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MEALZ_RS16780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MEALZ_RS16790	COG5000	phosphorelay sensor kinase activity
MEALZ_RS16795	COG2204	response regulator
MEALZ_RS16800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MEALZ_RS16805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MEALZ_RS16815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MEALZ_RS16820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MEALZ_RS16860	COG0714	Associated with various cellular activities
MEALZ_RS16870	COG2010	Cytochrome c
MEALZ_RS16875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MEALZ_RS16880	COG4993	Dehydrogenase
MEALZ_RS16895	COG5433	transposase activity
MEALZ_RS16915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MEALZ_RS16920	COG0598	Magnesium transport protein CorA
MEALZ_RS16935	COG0189	ligase activity
MEALZ_RS16945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MEALZ_RS16950	COG0825	malonyl-CoA metabolic process
MEALZ_RS16955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MEALZ_RS16960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MEALZ_RS16965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MEALZ_RS16980	COG2854	intermembrane phospholipid transfer
MEALZ_RS16985	COG4106	trans-aconitate 2-methyltransferase activity
MEALZ_RS16990	COG0500	methyltransferase
MEALZ_RS17000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MEALZ_RS17005	COG0322	excinuclease ABC activity
MEALZ_RS17015	COG0312	modulator of DNA gyrase
MEALZ_RS17020	COG0312	modulator of DNA gyrase
MEALZ_RS17040	COG1530	ribonuclease E activity
MEALZ_RS17045	COG0424	maF-like protein
MEALZ_RS17050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MEALZ_RS17060	COG0714	Associated with various cellular activities
MEALZ_RS17080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MEALZ_RS17100	COG3404	Formiminotransferase-cyclodeaminase
MEALZ_RS17105	COG0215	cysteine-tRNA ligase activity
MEALZ_RS17115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MEALZ_RS17120	COG0025	NhaP-type Na H and K H
MEALZ_RS17135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MEALZ_RS17145	COG0297	glycogen (starch) synthase activity
MEALZ_RS17150	COG1543	Belongs to the glycosyl hydrolase 57 family
MEALZ_RS17170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MEALZ_RS17175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MEALZ_RS17180	COG0297	glycogen (starch) synthase activity
MEALZ_RS17185	COG0513	Belongs to the DEAD box helicase family
MEALZ_RS17190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MEALZ_RS17195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MEALZ_RS17200	COG3178	'Phosphotransferase
MEALZ_RS17205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MEALZ_RS17210	COG3360	Dodecin
MEALZ_RS17230	COG1472	Belongs to the glycosyl hydrolase 3 family
MEALZ_RS17235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MEALZ_RS17240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MEALZ_RS17250	COG0446	pyridine nucleotide-disulphide oxidoreductase
MEALZ_RS17255	COG0784	Response regulator, receiver
MEALZ_RS17255	COG5002	protein histidine kinase activity
MEALZ_RS17255	COG2205	protein histidine kinase activity
MEALZ_RS17275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MEALZ_RS17285	COG0066	3-isopropylmalate dehydratase activity
MEALZ_RS17290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MEALZ_RS17295	COG0563	adenylate kinase activity
MEALZ_RS17300	COG2239	Acts as a magnesium transporter
MEALZ_RS17315	COG0408	coproporphyrinogen oxidase activity
MEALZ_RS17325	COG1047	Peptidyl-prolyl cis-trans
MEALZ_RS17330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MEALZ_RS17335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MEALZ_RS17370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MEALZ_RS17375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MEALZ_RS17385	COG2226	methyltransferase
MEALZ_RS17395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MEALZ_RS17400	COG0126	phosphoglycerate kinase activity
MEALZ_RS17405	COG1758	RNA polymerase activity
MEALZ_RS17410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MEALZ_RS17420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MEALZ_RS17425	COG3161	chorismate lyase activity
MEALZ_RS17435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MEALZ_RS17440	COG2226	methyltransferase
MEALZ_RS17450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MEALZ_RS17450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MEALZ_RS17455	COG1473	amidohydrolase
MEALZ_RS17460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MEALZ_RS17465	COG3094	Invasion gene expression up-regulator, SirB
MEALZ_RS17475	COG0784	Response regulator, receiver
MEALZ_RS17475	COG5002	protein histidine kinase activity
MEALZ_RS17475	COG2205	protein histidine kinase activity
MEALZ_RS17485	COG4771	TonB-dependent receptor
MEALZ_RS17490	COG0483	inositol monophosphate 1-phosphatase activity
MEALZ_RS17495	COG1785	Belongs to the alkaline phosphatase family
MEALZ_RS17505	COG5002	protein histidine kinase activity
MEALZ_RS17505	COG5001	Diguanylate cyclase
MEALZ_RS17520	COG4566	intracellular signal transduction
MEALZ_RS17550	COG3023	N-Acetylmuramoyl-L-alanine amidase
MEALZ_RS17560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MEALZ_RS17565	COG0196	riboflavin kinase activity
MEALZ_RS17570	COG0268	Binds directly to 16S ribosomal RNA
MEALZ_RS17575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MEALZ_RS17580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MEALZ_RS17585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MEALZ_RS17590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MEALZ_RS17595	COG0142	geranyltranstransferase activity
MEALZ_RS17620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MEALZ_RS17625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MEALZ_RS17640	COG1181	Belongs to the D-alanine--D-alanine ligase family
MEALZ_RS17645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MEALZ_RS17650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MEALZ_RS17655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MEALZ_RS17660	COG0772	Belongs to the SEDS family
MEALZ_RS17665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MEALZ_RS17670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MEALZ_RS17675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MEALZ_RS17695	COG0275	rRNA processing
MEALZ_RS17700	COG2001	Belongs to the MraZ family
MEALZ_RS17710	COG3107	peptidoglycan biosynthetic process
MEALZ_RS17715	COG0792	nuclease activity
MEALZ_RS17720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MEALZ_RS17730	COG1322	Protein conserved in bacteria
MEALZ_RS17735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MEALZ_RS17745	COG1074	ATP-dependent DNA helicase activity
MEALZ_RS17755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MEALZ_RS17760	COG1970	mechanosensitive ion channel activity
MEALZ_RS17765	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MEALZ_RS17780	COG2986	histidine ammonia-lyase
MEALZ_RS17800	COG0318	PFAM AMP-dependent synthetase and ligase
MEALZ_RS17810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MEALZ_RS17825	COG1561	YicC-like family, N-terminal region
MEALZ_RS17830	COG0515	serine threonine protein kinase
MEALZ_RS17830	COG2815	serine threonine protein kinase
MEALZ_RS17835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MEALZ_RS17840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MEALZ_RS17855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MEALZ_RS17860	COG4772	TonB-dependent receptor
MEALZ_RS17870	COG0475	glutathione-regulated potassium exporter activity
MEALZ_RS17875	COG2853	Lipoprotein
MEALZ_RS17880	COG0385	Bile acid
MEALZ_RS17885	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MEALZ_RS17905	COG1355	regulation of microtubule-based process
MEALZ_RS17915	COG1136	(ABC) transporter
MEALZ_RS17915	COG0577	efflux transmembrane transporter activity
MEALZ_RS17920	COG1136	(ABC) transporter
MEALZ_RS17920	COG0577	efflux transmembrane transporter activity
MEALZ_RS17930	COG1671	Belongs to the UPF0178 family
MEALZ_RS17935	COG0210	DNA helicase
MEALZ_RS18005	COG0732	type I restriction modification DNA specificity domain
MEALZ_RS18020	COG3436	PFAM IS66 Orf2 family protein
MEALZ_RS18025	COG4372	Transposase
MEALZ_RS18055	COG0784	Response regulator, receiver
MEALZ_RS18065	COG3300	MHYT domain
MEALZ_RS18065	COG5001	Diguanylate cyclase
MEALZ_RS18075	COG0741	lytic transglycosylase activity
MEALZ_RS18090	COG1538	Outer membrane efflux protein
MEALZ_RS18105	COG2274	protein secretion by the type I secretion system
MEALZ_RS18115	COG2197	response regulator
MEALZ_RS18170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MEALZ_RS18175	COG1518	maintenance of DNA repeat elements
MEALZ_RS18220	COG1857	crispr-associated protein
MEALZ_RS18245	COG1203	CRISPR-associated helicase, Cas3
MEALZ_RS18275	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MEALZ_RS18295	COG4181	ATPase activity
MEALZ_RS18315	COG0840	transmembrane signaling receptor activity
MEALZ_RS18320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MEALZ_RS18340	COG0356	it plays a direct role in the translocation of protons across the membrane
MEALZ_RS18350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MEALZ_RS18355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MEALZ_RS18360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MEALZ_RS18390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MEALZ_RS18395	COG1902	pentaerythritol trinitrate reductase activity
MEALZ_RS18405	COG1067	ATP-dependent peptidase activity
MEALZ_RS18445	COG0489	protein tyrosine kinase activity
MEALZ_RS18450	COG0717	Belongs to the dCTP deaminase family
MEALZ_RS18455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MEALZ_RS18460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MEALZ_RS18465	COG4558	Periplasmic binding protein
MEALZ_RS18470	COG0748	coenzyme F420 binding
MEALZ_RS18475	COG3720	iron ion transport
MEALZ_RS18540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MEALZ_RS18560	COG4974	Belongs to the 'phage' integrase family
MEALZ_RS18580	COG1960	acyl-CoA dehydrogenase activity
MEALZ_RS18595	COG4115	mRNA cleavage
MEALZ_RS18600	COG2161	toxin-antitoxin pair type II binding
MEALZ_RS18615	COG3609	addiction module antidote protein, CC2985 family
MEALZ_RS18650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MEALZ_RS18655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MEALZ_RS18695	COG1611	Belongs to the LOG family
MEALZ_RS18700	COG5001	Diguanylate cyclase
MEALZ_RS18700	COG5002	protein histidine kinase activity
MEALZ_RS18720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MEALZ_RS18735	COG1127	ABC transporter
MEALZ_RS18740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MEALZ_RS18760	COG1858	cytochrome C peroxidase
MEALZ_RS18780	COG0252	asparaginase activity
MEALZ_RS18785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MEALZ_RS18800	COG4115	mRNA cleavage
MEALZ_RS18820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MEALZ_RS18850	COG0538	isocitrate dehydrogenase activity
MEALZ_RS18860	COG1136	(ABC) transporter
MEALZ_RS18865	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MEALZ_RS18875	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS18880	COG2205	protein histidine kinase activity
MEALZ_RS18885	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS18910	COG0363	glucosamine-6-phosphate deaminase activity
MEALZ_RS18915	COG2234	aminopeptidase activity
MEALZ_RS18950	COG1966	Carbon starvation protein
MEALZ_RS18960	COG0003	Pfam Anion-transporting ATPase
MEALZ_RS18975	COG1793	dna ligase
MEALZ_RS18990	COG3706	GGDEF domain
MEALZ_RS18995	COG0500	methyltransferase
MEALZ_RS19005	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MEALZ_RS19010	COG1615	UPF0182 protein
MEALZ_RS19020	COG0308	aminopeptidase N
MEALZ_RS19025	COG2363	Small membrane protein
MEALZ_RS19030	COG0521	Mo-molybdopterin cofactor biosynthetic process
MEALZ_RS19035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MEALZ_RS19045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MEALZ_RS19050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MEALZ_RS19055	COG0189	ligase activity
MEALZ_RS19065	COG1678	Uncharacterized ACR, COG1678
MEALZ_RS19070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MEALZ_RS19075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MEALZ_RS19080	COG0540	Belongs to the ATCase OTCase family
MEALZ_RS19125	COG0642	Histidine kinase
MEALZ_RS19190	COG0668	transmembrane transport
MEALZ_RS19205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MEALZ_RS19210	COG0745	RESPONSE REGULATOR receiver
MEALZ_RS19235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MEALZ_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
MEALZ_RS19260	COG3093	addiction module antidote protein HigA
MEALZ_RS19265	COG3549	Plasmid maintenance system killer
MEALZ_RS19300	COG4657	Part of a membrane complex involved in electron transport
MEALZ_RS19305	COG4660	Part of a membrane complex involved in electron transport
MEALZ_RS19310	COG4659	FMN binding
MEALZ_RS19315	COG4658	electron transport chain
MEALZ_RS19320	COG4656	Part of a membrane complex involved in electron transport
MEALZ_RS19325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MEALZ_RS19325	COG0674	pyruvate-flavodoxin oxidoreductase activity
MEALZ_RS19325	COG1013	pyruvate-flavodoxin oxidoreductase activity
MEALZ_RS19325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MEALZ_RS19365	COG0446	pyridine nucleotide-disulphide oxidoreductase
MEALZ_RS19370	COG0191	fructose-bisphosphate aldolase activity
MEALZ_RS19375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MEALZ_RS19385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MEALZ_RS19400	COG0647	UMP catabolic process
MEALZ_RS19405	COG2376	Dihydroxyacetone kinase
MEALZ_RS19410	COG1461	Dihydroxyacetone kinase
MEALZ_RS19420	COG0494	nUDIX hydrolase
MEALZ_RS19425	COG1011	Hydrolase
MEALZ_RS19430	COG0513	Belongs to the DEAD box helicase family
MEALZ_RS19455	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MEALZ_RS19460	COG1194	a g-specific adenine glycosylase
MEALZ_RS19465	COG1773	rubredoxin
MEALZ_RS19485	COG0450	alkyl hydroperoxide reductase
MEALZ_RS19505	COG0848	biopolymer transport protein
MEALZ_RS19510	COG0811	peptide transport
MEALZ_RS19515	COG0811	peptide transport
MEALZ_RS19530	COG1473	amidohydrolase
MEALZ_RS19535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MEALZ_RS19540	COG0006	proline dipeptidase activity
MEALZ_RS19545	COG1012	belongs to the aldehyde dehydrogenase family
MEALZ_RS19595	COG0848	biopolymer transport protein
MEALZ_RS19600	COG0811	peptide transport
MEALZ_RS19605	COG0811	peptide transport
MEALZ_RS19630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MEALZ_RS19645	COG2239	Acts as a magnesium transporter
MEALZ_RS19660	COG0330	HflC and HflK could
MEALZ_RS19665	COG0330	HflC and HflK could
MEALZ_RS19680	COG1090	epimerase
MEALZ_RS19685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MEALZ_RS19685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MEALZ_RS19700	COG1136	(ABC) transporter
MEALZ_RS19705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MEALZ_RS19715	COG0601	transmembrane transport
MEALZ_RS19730	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MEALZ_RS19735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MEALZ_RS19750	COG0640	Transcriptional regulator
MEALZ_RS19765	COG2304	oxidoreductase activity
MEALZ_RS19785	COG0714	Associated with various cellular activities
MEALZ_RS19800	COG0300	oxidoreductase activity
MEALZ_RS19900	COG0582	viral genome integration into host DNA
MEALZ_RS19915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MEALZ_RS19920	COG0706	membrane insertase activity
MEALZ_RS19925	COG0594	ribonuclease P activity
MEALZ_RS20470	COG1132	(ABC) transporter
MEALZ_RS20505	COG2815	serine threonine protein kinase
MEALZ_RS20505	COG0515	serine threonine protein kinase
MEALZ_RS20540	COG5002	protein histidine kinase activity
MEALZ_RS20540	COG2205	protein histidine kinase activity
MEALZ_RS20540	COG0784	Response regulator, receiver
MEALZ_RS20560	COG3706	GGDEF domain
MEALZ_RS20560	COG2203	Gaf domain
MEALZ_RS20560	COG5001	Diguanylate cyclase
MEALZ_RS20560	COG4251	negative regulation of phosphorylation
MEALZ_RS20570	COG1216	Glycosyl transferase, family 2
MEALZ_RS20600	COG4251	negative regulation of phosphorylation
MEALZ_RS20620	COG5002	protein histidine kinase activity
MEALZ_RS20620	COG2205	protein histidine kinase activity
MEALZ_RS20620	COG0784	Response regulator, receiver
MEALZ_RS20640	COG4970	Tfp pilus assembly protein FimT
MEALZ_RS20690	COG3447	MASE1 domain protein
MEALZ_RS20690	COG5001	Diguanylate cyclase
MEALZ_RS20690	COG5002	protein histidine kinase activity
MEALZ_RS20700	COG0631	protein serine/threonine phosphatase activity
MEALZ_RS20730	COG0515	serine threonine protein kinase
MEALZ_RS20780	COG0438	transferase activity, transferring glycosyl groups
MEALZ_RS20810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MEALZ_RS20815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MEALZ_RS20825	COG4191	Histidine kinase
MEALZ_RS20835	COG2197	response regulator
MEALZ_RS20850	COG0444	Belongs to the ABC transporter superfamily
MEALZ_RS20855	COG4608	Belongs to the ABC transporter superfamily
MEALZ_RS20875	COG2840	Smr protein MutS2
MEALZ_RS20885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MEALZ_RS20885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MEALZ_RS20950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MEALZ_RS20955	COG4251	negative regulation of phosphorylation
MEALZ_RS20965	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MEALZ_RS20970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MEALZ_RS21015	COG0840	transmembrane signaling receptor activity
MEALZ_RS21020	COG3064	Membrane
MEALZ_RS21050	COG2205	protein histidine kinase activity
MEALZ_RS21055	COG4191	Histidine kinase
MEALZ_RS21060	COG4251	negative regulation of phosphorylation
MEALZ_RS21065	COG3156	type II secretion system protein K
MEALZ_RS21090	COG2755	lipolytic protein G-D-S-L family
MEALZ_RS21090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups