locus-tag	class	description
MKLM6_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MKLM6_RS00030	COG0842	Transport permease protein
MKLM6_RS00035	COG1129	ABC transporter
MKLM6_RS00035	COG0842	Transport permease protein
MKLM6_RS00040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS00075	COG1846	Transcriptional regulator
MKLM6_RS00085	COG4983	Phage plasmid primase, P4 family domain protein
MKLM6_RS00090	COG1475	DNA binding
MKLM6_RS00115	COG3012	SEC-C Motif Domain Protein
MKLM6_RS00120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MKLM6_RS00120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MKLM6_RS00125	COG2135	peptidase activity
MKLM6_RS00145	COG2003	Belongs to the UPF0758 family
MKLM6_RS00195	COG0842	Transport permease protein
MKLM6_RS00200	COG1131	(ABC) transporter
MKLM6_RS00245	COG0582	viral genome integration into host DNA
MKLM6_RS00270	COG3328	transposase activity
MKLM6_RS00310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MKLM6_RS00310	COG0519	Catalyzes the synthesis of GMP from XMP
MKLM6_RS00335	COG3100	YcgL domain-containing protein
MKLM6_RS00350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKLM6_RS00355	COG2373	Large extracellular alpha-helical protein
MKLM6_RS00370	COG1902	pentaerythritol trinitrate reductase activity
MKLM6_RS00400	COG0500	methyltransferase
MKLM6_RS00435	COG3384	dioxygenase
MKLM6_RS00440	COG1301	dicarboxylic acid transport
MKLM6_RS00445	COG4636	protein conserved in cyanobacteria
MKLM6_RS00455	COG1234	tRNA 3'-trailer cleavage
MKLM6_RS00460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MKLM6_RS00460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MKLM6_RS00465	COG1393	Belongs to the ArsC family
MKLM6_RS00490	COG3045	CreA protein
MKLM6_RS00495	COG2205	protein histidine kinase activity
MKLM6_RS00495	COG3850	Histidine kinase
MKLM6_RS00495	COG4999	Histidine kinase
MKLM6_RS00495	COG3437	response regulator, receiver
MKLM6_RS00575	COG1067	ATP-dependent peptidase activity
MKLM6_RS00580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKLM6_RS00580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKLM6_RS00590	COG0445	tRNA wobble uridine modification
MKLM6_RS00595	COG0357	Ribosomal RNA small subunit methyltransferase G
MKLM6_RS00600	COG1192	Involved in chromosome partitioning
MKLM6_RS00605	COG1475	DNA binding
MKLM6_RS00615	COG0356	it plays a direct role in the translocation of protons across the membrane
MKLM6_RS00625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MKLM6_RS00630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKLM6_RS00635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MKLM6_RS00640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MKLM6_RS00645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MKLM6_RS00650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MKLM6_RS00655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MKLM6_RS00660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MKLM6_RS00665	COG0590	tRNA wobble adenosine to inosine editing
MKLM6_RS00665	COG0037	tRNA processing
MKLM6_RS00670	COG5001	Diguanylate cyclase
MKLM6_RS00670	COG3300	MHYT domain
MKLM6_RS00675	COG0456	acetyltransferase
MKLM6_RS00680	COG3279	Response regulator of the LytR AlgR family
MKLM6_RS00685	COG3275	phosphorelay sensor kinase activity
MKLM6_RS00695	COG1595	DNA-templated transcription, initiation
MKLM6_RS00755	COG0217	transcriptional regulatory protein
MKLM6_RS00765	COG0517	IMP dehydrogenase activity
MKLM6_RS00785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MKLM6_RS00790	COG1064	alcohol dehydrogenase
MKLM6_RS00795	COG1194	a g-specific adenine glycosylase
MKLM6_RS00800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MKLM6_RS00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKLM6_RS00825	COG0823	Involved in the tonB-independent uptake of proteins
MKLM6_RS00850	COG1032	radical SAM domain protein
MKLM6_RS00855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKLM6_RS00860	COG0723	plastoquinol--plastocyanin reductase activity
MKLM6_RS00865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MKLM6_RS00870	COG2857	Cytochrome c1
MKLM6_RS00880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKLM6_RS00895	COG4585	Histidine kinase
MKLM6_RS00900	COG2197	response regulator
MKLM6_RS00910	COG0425	Belongs to the sulfur carrier protein TusA family
MKLM6_RS00935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MKLM6_RS00950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MKLM6_RS00955	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MKLM6_RS00960	COG0237	dephospho-CoA kinase activity
MKLM6_RS00965	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MKLM6_RS00980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MKLM6_RS00985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKLM6_RS00995	COG0142	geranyltranstransferase activity
MKLM6_RS01000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MKLM6_RS01005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MKLM6_RS01010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MKLM6_RS01015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MKLM6_RS01020	COG0489	protein tyrosine kinase activity
MKLM6_RS01025	COG1376	ErfK ybiS ycfS ynhG family protein
MKLM6_RS01025	COG1388	LysM domain
MKLM6_RS01045	COG0110	maltose O-acetyltransferase activity
MKLM6_RS01055	COG0297	glycogen (starch) synthase activity
MKLM6_RS01060	COG0463	Glycosyl transferase, family 2
MKLM6_RS01070	COG0110	maltose O-acetyltransferase activity
MKLM6_RS01080	COG0297	glycogen (starch) synthase activity
MKLM6_RS01110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKLM6_RS01115	COG0284	orotidine-5'-phosphate decarboxylase activity
MKLM6_RS01120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MKLM6_RS01125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MKLM6_RS01135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MKLM6_RS01140	COG0432	Pfam Uncharacterised protein family UPF0047
MKLM6_RS01150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKLM6_RS01155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKLM6_RS01170	COG1360	Flagellar Motor Protein
MKLM6_RS01175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MKLM6_RS01190	COG1968	undecaprenyl-diphosphatase activity
MKLM6_RS01210	COG4771	TonB-dependent receptor
MKLM6_RS01215	COG1429	ligase activity, forming nitrogen-metal bonds
MKLM6_RS01315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MKLM6_RS01330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKLM6_RS01330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MKLM6_RS01335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKLM6_RS01365	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MKLM6_RS01390	COG0642	Histidine kinase
MKLM6_RS01420	COG2104	thiamine diphosphate biosynthetic process
MKLM6_RS01420	COG2022	thiamine diphosphate biosynthetic process
MKLM6_RS01425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKLM6_RS01440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MKLM6_RS01450	COG4206	TonB-dependent receptor
MKLM6_RS01460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKLM6_RS01465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MKLM6_RS01470	COG0742	ribosomal rna small subunit methyltransferase
MKLM6_RS01475	COG0612	Peptidase, M16
MKLM6_RS01480	COG0612	Peptidase, M16
MKLM6_RS01485	COG0109	protoheme IX farnesyltransferase activity
MKLM6_RS01490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKLM6_RS01495	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKLM6_RS01495	COG0493	'glutamate synthase
MKLM6_RS01505	COG3328	transposase activity
MKLM6_RS01515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MKLM6_RS01525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKLM6_RS01540	COG0134	indole-3-glycerol-phosphate synthase activity
MKLM6_RS01555	COG3108	Peptidase M15
MKLM6_RS01585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MKLM6_RS01590	COG0107	imidazoleglycerol-phosphate synthase activity
MKLM6_RS01595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MKLM6_RS01600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MKLM6_RS01605	COG0131	Imidazoleglycerol-phosphate dehydratase
MKLM6_RS01610	COG0308	aminopeptidase N
MKLM6_RS01620	COG2363	Small membrane protein
MKLM6_RS01625	COG0521	Mo-molybdopterin cofactor biosynthetic process
MKLM6_RS01630	COG0628	permease
MKLM6_RS01675	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MKLM6_RS01680	COG0752	glycyl-tRNA synthetase alpha subunit
MKLM6_RS01685	COG0751	glycine-tRNA ligase activity
MKLM6_RS01725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MKLM6_RS01740	COG0330	HflC and HflK could
MKLM6_RS01760	COG0714	Associated with various cellular activities
MKLM6_RS01770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MKLM6_RS01780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKLM6_RS01810	COG2132	Multicopper oxidase
MKLM6_RS01815	COG1615	UPF0182 protein
MKLM6_RS01835	COG0300	oxidoreductase activity
MKLM6_RS01845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MKLM6_RS01850	COG1074	ATP-dependent DNA helicase activity
MKLM6_RS01890	COG1858	cytochrome C peroxidase
MKLM6_RS01915	COG0488	(ABC) transporter
MKLM6_RS01925	COG0589	response to stress
MKLM6_RS01935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MKLM6_RS01945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MKLM6_RS01950	COG0778	Nitroreductase
MKLM6_RS01955	COG1492	cobalamin metabolic process
MKLM6_RS01970	COG2954	triphosphatase activity
MKLM6_RS01975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MKLM6_RS01980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MKLM6_RS01990	COG0778	Nitroreductase
MKLM6_RS01995	COG3706	GGDEF domain
MKLM6_RS02020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS02060	COG0210	DNA helicase
MKLM6_RS02070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKLM6_RS02075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MKLM6_RS02080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MKLM6_RS02085	COG0189	ligase activity
MKLM6_RS02095	COG1678	Uncharacterized ACR, COG1678
MKLM6_RS02100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MKLM6_RS02105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MKLM6_RS02110	COG0540	Belongs to the ATCase OTCase family
MKLM6_RS02125	COG0714	Associated with various cellular activities
MKLM6_RS02150	COG2304	oxidoreductase activity
MKLM6_RS02155	COG1253	flavin adenine dinucleotide binding
MKLM6_RS02175	COG0494	nUDIX hydrolase
MKLM6_RS02180	COG0840	transmembrane signaling receptor activity
MKLM6_RS02185	COG1011	Hydrolase
MKLM6_RS02205	COG4178	(ABC) transporter
MKLM6_RS02220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MKLM6_RS02225	COG0315	cyclic pyranopterin monophosphate synthase activity
MKLM6_RS02235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKLM6_RS02245	COG1530	ribonuclease E activity
MKLM6_RS02250	COG0424	maF-like protein
MKLM6_RS02255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MKLM6_RS02260	COG4636	protein conserved in cyanobacteria
MKLM6_RS02300	COG3002	Belongs to the UPF0753 family
MKLM6_RS02305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKLM6_RS02310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MKLM6_RS02320	COG0288	reversible hydration of carbon dioxide
MKLM6_RS02325	COG0659	secondary active sulfate transmembrane transporter activity
MKLM6_RS02335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MKLM6_RS02340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MKLM6_RS02350	COG1561	YicC-like family, N-terminal region
MKLM6_RS02355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MKLM6_RS02400	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MKLM6_RS02415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS02430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MKLM6_RS02435	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MKLM6_RS02445	COG1739	Uncharacterized protein family UPF0029
MKLM6_RS02460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKLM6_RS02475	COG0519	Catalyzes the synthesis of GMP from XMP
MKLM6_RS02485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKLM6_RS02495	COG0429	hydrolase of the alpha beta-hydrolase fold
MKLM6_RS02510	COG0408	coproporphyrinogen oxidase activity
MKLM6_RS02525	COG3012	SEC-C Motif Domain Protein
MKLM6_RS02530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MKLM6_RS02540	COG1917	Cupin 2, conserved barrel domain protein
MKLM6_RS02540	COG4977	sequence-specific DNA binding
MKLM6_RS02570	COG0181	hydroxymethylbilane synthase activity
MKLM6_RS02595	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS02600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MKLM6_RS02635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MKLM6_RS02645	COG2854	intermembrane phospholipid transfer
MKLM6_RS02650	COG4106	trans-aconitate 2-methyltransferase activity
MKLM6_RS02655	COG0500	methyltransferase
MKLM6_RS02660	COG1555	photosystem II stabilization
MKLM6_RS02670	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MKLM6_RS02685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKLM6_RS02695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKLM6_RS02730	COG1987	bacterial-type flagellum assembly
MKLM6_RS02745	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MKLM6_RS02770	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MKLM6_RS02775	COG2198	Histidine kinase
MKLM6_RS02775	COG0643	Histidine kinase
MKLM6_RS02775	COG0784	Response regulator, receiver
MKLM6_RS02780	COG2201	protein-glutamate methylesterase activity
MKLM6_RS02785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MKLM6_RS02795	COG1192	Involved in chromosome partitioning
MKLM6_RS02805	COG0835	chemotaxis
MKLM6_RS02815	COG1216	Glycosyl transferase, family 2
MKLM6_RS02840	COG0859	PFAM glycosyl transferase family 9
MKLM6_RS02845	COG1132	(ABC) transporter
MKLM6_RS02850	COG0535	radical SAM domain protein
MKLM6_RS02870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MKLM6_RS02880	COG0730	response to heat
MKLM6_RS02885	COG0617	tRNA 3'-terminal CCA addition
MKLM6_RS02895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MKLM6_RS02905	COG0312	modulator of DNA gyrase
MKLM6_RS02910	COG0312	modulator of DNA gyrase
MKLM6_RS02920	COG0167	dihydroorotate dehydrogenase activity
MKLM6_RS02950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKLM6_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
MKLM6_RS02985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKLM6_RS02990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MKLM6_RS02995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MKLM6_RS03000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MKLM6_RS03005	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MKLM6_RS03010	COG1610	YqeY-like protein
MKLM6_RS03015	COG0358	DNA primase activity
MKLM6_RS03030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MKLM6_RS03035	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MKLM6_RS03045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKLM6_RS03070	COG1858	cytochrome C peroxidase
MKLM6_RS03085	COG5002	protein histidine kinase activity
MKLM6_RS03085	COG5001	Diguanylate cyclase
MKLM6_RS03085	COG3447	MASE1 domain protein
MKLM6_RS03095	COG1294	oxidase, subunit
MKLM6_RS03110	COG0501	Belongs to the peptidase M48B family
MKLM6_RS03120	COG2171	N-acyltransferase activity
MKLM6_RS03140	COG1295	ribonuclease BN
MKLM6_RS03150	COG1393	Belongs to the ArsC family
MKLM6_RS03155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MKLM6_RS03170	COG2003	Belongs to the UPF0758 family
MKLM6_RS03175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKLM6_RS03180	COG0756	dUTP diphosphatase activity
MKLM6_RS03190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MKLM6_RS03210	COG0728	peptidoglycan biosynthetic process
MKLM6_RS03215	COG0268	Binds directly to 16S ribosomal RNA
MKLM6_RS03235	COG0542	response to heat
MKLM6_RS03240	COG1278	Cold shock
MKLM6_RS03260	COG2218	PFAM glutamate synthase alpha subunit domain protein
MKLM6_RS03265	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MKLM6_RS03270	COG2890	protein-(glutamine-N5) methyltransferase activity
MKLM6_RS03290	COG1229	Formylmethanofuran dehydrogenase subunit A
MKLM6_RS03300	COG2154	pterin-4-alpha-carbinolamine dehydratase
MKLM6_RS03320	COG3128	pkhd-type hydroxylase
MKLM6_RS03330	COG4774	siderophore transport
MKLM6_RS03365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MKLM6_RS03370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKLM6_RS03375	COG4558	Periplasmic binding protein
MKLM6_RS03380	COG0748	coenzyme F420 binding
MKLM6_RS03385	COG3720	iron ion transport
MKLM6_RS03400	COG1629	transport
MKLM6_RS03400	COG4771	TonB-dependent receptor
MKLM6_RS03425	COG4256	Hemin uptake protein
MKLM6_RS03455	COG0459	protein refolding
MKLM6_RS03460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MKLM6_RS03485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MKLM6_RS03510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MKLM6_RS03520	COG4636	protein conserved in cyanobacteria
MKLM6_RS03525	COG2226	methyltransferase
MKLM6_RS03535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MKLM6_RS03540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MKLM6_RS03565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKLM6_RS03575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKLM6_RS03610	COG2205	protein histidine kinase activity
MKLM6_RS03610	COG0784	Response regulator, receiver
MKLM6_RS03615	COG4566	intracellular signal transduction
MKLM6_RS03620	COG0517	IMP dehydrogenase activity
MKLM6_RS03620	COG0516	GMP reductase activity
MKLM6_RS03625	COG4566	intracellular signal transduction
MKLM6_RS03635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MKLM6_RS03685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKLM6_RS03700	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS03710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKLM6_RS03715	COG0473	3-isopropylmalate dehydrogenase activity
MKLM6_RS03720	COG0066	3-isopropylmalate dehydratase activity
MKLM6_RS03725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MKLM6_RS03730	COG0563	adenylate kinase activity
MKLM6_RS03735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MKLM6_RS03740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MKLM6_RS03745	COG1846	Transcriptional regulator
MKLM6_RS03750	COG2010	Cytochrome c
MKLM6_RS03755	COG2863	cytochrome
MKLM6_RS03790	COG0535	radical SAM domain protein
MKLM6_RS03800	COG0316	Belongs to the HesB IscA family
MKLM6_RS03815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKLM6_RS03850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKLM6_RS03855	COG0560	Phosphoserine phosphatase
MKLM6_RS03855	COG3830	Belongs to the UPF0237 family
MKLM6_RS03860	COG0217	transcriptional regulatory protein
MKLM6_RS03865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MKLM6_RS03870	COG0632	four-way junction helicase activity
MKLM6_RS03875	COG2255	four-way junction helicase activity
MKLM6_RS03880	COG0824	Thioesterase
MKLM6_RS03900	COG0823	Involved in the tonB-independent uptake of proteins
MKLM6_RS03905	COG2885	chlorophyll binding
MKLM6_RS03910	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MKLM6_RS03915	COG0602	queuosine metabolic process
MKLM6_RS03920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MKLM6_RS03935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKLM6_RS03940	COG1702	phosphate starvation-inducible protein PhoH
MKLM6_RS03945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MKLM6_RS03950	COG4535	Mg2 and Co2 transporter CorC
MKLM6_RS03960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MKLM6_RS03970	COG0297	glycogen (starch) synthase activity
MKLM6_RS03975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MKLM6_RS03980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKLM6_RS03990	COG1640	4-alpha-glucanotransferase
MKLM6_RS04005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKLM6_RS04010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MKLM6_RS04020	COG0126	phosphoglycerate kinase activity
MKLM6_RS04050	COG1543	Belongs to the glycosyl hydrolase 57 family
MKLM6_RS04065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MKLM6_RS04070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MKLM6_RS04115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKLM6_RS04130	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MKLM6_RS04165	COG3609	addiction module antidote protein, CC2985 family
MKLM6_RS04295	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MKLM6_RS04335	COG0582	viral genome integration into host DNA
MKLM6_RS04415	COG1253	flavin adenine dinucleotide binding
MKLM6_RS04430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKLM6_RS04435	COG0006	proline dipeptidase activity
MKLM6_RS04440	COG3079	Belongs to the UPF0149 family
MKLM6_RS04460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MKLM6_RS04465	COG0825	malonyl-CoA metabolic process
MKLM6_RS04470	COG0037	tRNA processing
MKLM6_RS04485	COG0504	CTP synthase activity
MKLM6_RS04490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MKLM6_RS04500	COG0148	phosphopyruvate hydratase activity
MKLM6_RS04505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MKLM6_RS04510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MKLM6_RS04515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MKLM6_RS04520	COG0585	pseudouridine synthase activity
MKLM6_RS04535	COG2197	response regulator
MKLM6_RS04540	COG1538	Outer membrane efflux protein
MKLM6_RS04570	COG3706	GGDEF domain
MKLM6_RS04605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MKLM6_RS04620	COG3086	response to oxidative stress
MKLM6_RS04635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MKLM6_RS04640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKLM6_RS04645	COG0631	protein serine/threonine phosphatase activity
MKLM6_RS04650	COG2815	serine threonine protein kinase
MKLM6_RS04650	COG0515	serine threonine protein kinase
MKLM6_RS04660	COG1716	ATPase activity
MKLM6_RS04690	COG1666	GTP binding
MKLM6_RS04700	COG0433	COG0433 Predicted ATPase
MKLM6_RS04740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MKLM6_RS04745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MKLM6_RS04750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MKLM6_RS04760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKLM6_RS04765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MKLM6_RS04770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKLM6_RS04830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKLM6_RS04845	COG4137	Cytochrome C assembly protein
MKLM6_RS04850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKLM6_RS04855	COG0228	four-way junction DNA binding
MKLM6_RS04860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MKLM6_RS04870	COG0335	large ribosomal subunit rRNA binding
MKLM6_RS04880	COG4974	Belongs to the 'phage' integrase family
MKLM6_RS04885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKLM6_RS04900	COG5002	protein histidine kinase activity
MKLM6_RS04900	COG5001	Diguanylate cyclase
MKLM6_RS04915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKLM6_RS04920	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKLM6_RS04930	COG0071	Belongs to the small heat shock protein (HSP20) family
MKLM6_RS04940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKLM6_RS04975	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
MKLM6_RS04980	COG3411	Ferredoxin
MKLM6_RS05005	COG0247	lactate metabolic process
MKLM6_RS05015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MKLM6_RS05020	COG2755	lipolytic protein G-D-S-L family
MKLM6_RS05020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MKLM6_RS05035	COG0477	Major facilitator Superfamily
MKLM6_RS05050	COG0494	nUDIX hydrolase
MKLM6_RS05060	COG0501	Belongs to the peptidase M48B family
MKLM6_RS05080	COG1902	pentaerythritol trinitrate reductase activity
MKLM6_RS05105	COG0746	molybdenum cofactor guanylyltransferase activity
MKLM6_RS05135	COG0569	domain protein
MKLM6_RS05135	COG2985	domain, Protein
MKLM6_RS05155	COG2205	protein histidine kinase activity
MKLM6_RS05160	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS05165	COG3678	ATP-independent chaperone mediated protein folding
MKLM6_RS05170	COG0505	Belongs to the CarA family
MKLM6_RS05175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MKLM6_RS05180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKLM6_RS05190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MKLM6_RS05200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKLM6_RS05205	COG0149	triose-phosphate isomerase activity
MKLM6_RS05220	COG0582	viral genome integration into host DNA
MKLM6_RS05260	COG0616	signal peptide processing
MKLM6_RS05345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKLM6_RS05345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKLM6_RS05380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MKLM6_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
MKLM6_RS05395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MKLM6_RS05415	COG0625	glutathione transferase activity
MKLM6_RS05425	COG3328	transposase activity
MKLM6_RS05505	COG4771	TonB-dependent receptor
MKLM6_RS05510	COG0288	reversible hydration of carbon dioxide
MKLM6_RS05515	COG0659	secondary active sulfate transmembrane transporter activity
MKLM6_RS05525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKLM6_RS05535	COG4771	TonB-dependent receptor
MKLM6_RS05580	COG1487	ribonuclease activity
MKLM6_RS05590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKLM6_RS05610	COG5002	protein histidine kinase activity
MKLM6_RS05620	COG0697	spore germination
MKLM6_RS05625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKLM6_RS05635	COG1067	ATP-dependent peptidase activity
MKLM6_RS05640	COG0673	inositol 2-dehydrogenase activity
MKLM6_RS05650	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKLM6_RS05655	COG0343	queuine tRNA-ribosyltransferase activity
MKLM6_RS05660	COG3437	response regulator, receiver
MKLM6_RS05665	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS05675	COG2193	ferroxidase activity
MKLM6_RS05690	COG1943	Transposase
MKLM6_RS05765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MKLM6_RS05775	COG0280	phosphate acetyltransferase
MKLM6_RS05775	COG0857	belongs to the CobB CobQ family
MKLM6_RS05795	COG1451	nucleotide metabolic process
MKLM6_RS05810	COG2346	COG2346, Truncated hemoglobins
MKLM6_RS05840	COG0456	acetyltransferase
MKLM6_RS05845	COG1573	uracil-dna glycosylase
MKLM6_RS05850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKLM6_RS05860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MKLM6_RS05865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MKLM6_RS05870	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MKLM6_RS05875	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS05880	COG2205	protein histidine kinase activity
MKLM6_RS05905	COG1487	ribonuclease activity
MKLM6_RS06025	COG3604	Transcriptional regulator
MKLM6_RS06060	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MKLM6_RS06100	COG0515	serine threonine protein kinase
MKLM6_RS06100	COG2815	serine threonine protein kinase
MKLM6_RS06225	COG0582	viral genome integration into host DNA
MKLM6_RS06285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKLM6_RS06295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MKLM6_RS06300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MKLM6_RS06305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MKLM6_RS06310	COG0470	DNA polymerase III
MKLM6_RS06320	COG0084	hydrolase, TatD family'
MKLM6_RS06325	COG2813	Specifically methylates the guanine in position
MKLM6_RS06330	COG0463	Glycosyl transferase, family 2
MKLM6_RS06335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKLM6_RS06340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MKLM6_RS06360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKLM6_RS06365	COG1657	PFAM Prenyltransferase squalene oxidase
MKLM6_RS06375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKLM6_RS06385	COG2853	Lipoprotein
MKLM6_RS06390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKLM6_RS06395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MKLM6_RS06400	COG0142	geranyltranstransferase activity
MKLM6_RS06405	COG1722	exodeoxyribonuclease VII activity
MKLM6_RS06410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MKLM6_RS06490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS06495	COG1309	transcriptional regulator
MKLM6_RS06500	COG0784	Response regulator, receiver
MKLM6_RS06500	COG5002	protein histidine kinase activity
MKLM6_RS06500	COG2205	protein histidine kinase activity
MKLM6_RS06505	COG1301	dicarboxylic acid transport
MKLM6_RS06515	COG3104	oligopeptide transport
MKLM6_RS06540	COG2144	transferase activity, transferring acyl groups
MKLM6_RS06545	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS06555	COG2072	flavoprotein involved in K transport
MKLM6_RS06560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKLM6_RS06590	COG1203	CRISPR-associated helicase, Cas3
MKLM6_RS06635	COG1857	crispr-associated protein
MKLM6_RS06660	COG1518	maintenance of DNA repeat elements
MKLM6_RS06690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MKLM6_RS06695	COG0830	nickel cation binding
MKLM6_RS06700	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MKLM6_RS06705	COG0804	urea catabolic process
MKLM6_RS06710	COG0832	Belongs to the urease beta subunit family
MKLM6_RS06720	COG0831	urea catabolic process
MKLM6_RS06725	COG2161	toxin-antitoxin pair type II binding
MKLM6_RS06730	COG4115	mRNA cleavage
MKLM6_RS06790	COG0559	Belongs to the binding-protein-dependent transport system permease family
MKLM6_RS06815	COG1943	Transposase
MKLM6_RS06825	COG0784	Response regulator, receiver
MKLM6_RS06825	COG2198	Histidine kinase
MKLM6_RS06825	COG5002	protein histidine kinase activity
MKLM6_RS06840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MKLM6_RS06845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKLM6_RS06850	COG0416	fatty acid biosynthetic process
MKLM6_RS06860	COG1399	metal-binding, possibly nucleic acid-binding protein
MKLM6_RS06865	COG0424	maF-like protein
MKLM6_RS06875	COG0741	lytic transglycosylase activity
MKLM6_RS06880	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MKLM6_RS06885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKLM6_RS06890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MKLM6_RS06895	COG0302	gtp cyclohydrolase
MKLM6_RS06900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKLM6_RS06905	COG5002	protein histidine kinase activity
MKLM6_RS06905	COG5001	Diguanylate cyclase
MKLM6_RS06920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MKLM6_RS06925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKLM6_RS06930	COG0469	pyruvate kinase activity
MKLM6_RS06965	COG0210	DNA helicase
MKLM6_RS06980	COG1324	tolerance protein
MKLM6_RS06985	COG4232	protein-disulfide reductase activity
MKLM6_RS06990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKLM6_RS06995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MKLM6_RS07000	COG0511	ligase activity, forming carbon-carbon bonds
MKLM6_RS07005	COG0439	Biotin carboxylase
MKLM6_RS07010	COG2264	protein methyltransferase activity
MKLM6_RS07020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKLM6_RS07040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MKLM6_RS07045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKLM6_RS07080	COG1525	nuclease
MKLM6_RS07090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MKLM6_RS07095	COG1160	GTP binding
MKLM6_RS07100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKLM6_RS07110	COG0124	histidyl-tRNA synthetase
MKLM6_RS07120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MKLM6_RS07125	COG0105	UTP biosynthetic process
MKLM6_RS07130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKLM6_RS07135	COG1862	Preprotein translocase
MKLM6_RS07140	COG0688	phosphatidylethanolamine metabolic process
MKLM6_RS07150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKLM6_RS07165	COG1196	nuclear chromosome segregation
MKLM6_RS07170	COG3115	cell septum assembly
MKLM6_RS07175	COG0481	GTPase activity
MKLM6_RS07180	COG0681	Belongs to the peptidase S26 family
MKLM6_RS07190	COG0571	ribonuclease III activity
MKLM6_RS07195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MKLM6_RS07205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MKLM6_RS07215	COG2204	response regulator
MKLM6_RS07225	COG4251	negative regulation of phosphorylation
MKLM6_RS07225	COG3706	GGDEF domain
MKLM6_RS07225	COG2203	Gaf domain
MKLM6_RS07225	COG5001	Diguanylate cyclase
MKLM6_RS07230	COG3850	Histidine kinase
MKLM6_RS07230	COG2205	protein histidine kinase activity
MKLM6_RS07230	COG3437	response regulator, receiver
MKLM6_RS07230	COG4999	Histidine kinase
MKLM6_RS07235	COG1509	lysine 2,3-aminomutase activity
MKLM6_RS07240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MKLM6_RS07245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MKLM6_RS07255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MKLM6_RS07265	COG0418	dihydroorotase activity
MKLM6_RS07275	COG0463	Glycosyl transferase, family 2
MKLM6_RS07290	COG1981	membrane
MKLM6_RS07295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MKLM6_RS07300	COG3178	'Phosphotransferase
MKLM6_RS07305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MKLM6_RS07310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKLM6_RS07320	COG4772	TonB-dependent receptor
MKLM6_RS07325	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MKLM6_RS07335	COG2119	membrane
MKLM6_RS07360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MKLM6_RS07365	COG1797	cobyrinic acid a,c-diamide synthase activity
MKLM6_RS07370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MKLM6_RS07375	COG2137	regulation of response to DNA damage stimulus
MKLM6_RS07380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MKLM6_RS07410	COG2217	Heavy metal translocating P-type atpase
MKLM6_RS07445	COG4983	Phage plasmid primase, P4 family domain protein
MKLM6_RS07455	COG0582	viral genome integration into host DNA
MKLM6_RS07460	COG1335	isochorismatase
MKLM6_RS07470	COG0583	DNA-binding transcription factor activity
MKLM6_RS07490	COG1451	nucleotide metabolic process
MKLM6_RS07495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MKLM6_RS07500	COG3177	Filamentation induced by cAMP protein fic
MKLM6_RS07510	COG2852	Protein conserved in bacteria
MKLM6_RS07515	COG2026	Addiction module toxin, RelE StbE family
MKLM6_RS07550	COG0642	Histidine kinase
MKLM6_RS07625	COG1301	dicarboxylic acid transport
MKLM6_RS07630	COG3706	GGDEF domain
MKLM6_RS07660	COG1451	nucleotide metabolic process
MKLM6_RS07680	COG1487	ribonuclease activity
MKLM6_RS07685	COG4456	Virulence-associated protein
MKLM6_RS07705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MKLM6_RS07720	COG0575	Belongs to the CDS family
MKLM6_RS07750	COG2814	Major facilitator Superfamily
MKLM6_RS07755	COG0629	single-stranded DNA binding
MKLM6_RS07785	COG1063	alcohol dehydrogenase
MKLM6_RS07800	COG0564	pseudouridine synthase activity
MKLM6_RS07805	COG4636	protein conserved in cyanobacteria
MKLM6_RS07825	COG0473	3-isopropylmalate dehydrogenase activity
MKLM6_RS07850	COG0488	(ABC) transporter
MKLM6_RS07860	COG1595	DNA-templated transcription, initiation
MKLM6_RS07895	COG4191	Histidine kinase
MKLM6_RS07970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MKLM6_RS07975	COG0659	secondary active sulfate transmembrane transporter activity
MKLM6_RS08025	COG4232	protein-disulfide reductase activity
MKLM6_RS08040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MKLM6_RS08045	COG3645	SOS response
MKLM6_RS08060	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MKLM6_RS08065	COG4185	zeta toxin
MKLM6_RS08090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKLM6_RS08140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKLM6_RS08140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKLM6_RS08145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKLM6_RS08145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKLM6_RS08150	COG0436	Aminotransferase
MKLM6_RS08235	COG2863	cytochrome
MKLM6_RS08250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKLM6_RS08255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MKLM6_RS08300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKLM6_RS08450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MKLM6_RS08455	COG1127	ABC transporter
MKLM6_RS08460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MKLM6_RS08460	COG3008	intermembrane lipid transfer
MKLM6_RS08470	COG2116	formate transmembrane transporter activity
MKLM6_RS08475	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MKLM6_RS08480	COG2815	serine threonine protein kinase
MKLM6_RS08480	COG0515	serine threonine protein kinase
MKLM6_RS08485	COG2223	nitrite transmembrane transporter activity
MKLM6_RS08495	COG2815	serine threonine protein kinase
MKLM6_RS08495	COG0515	serine threonine protein kinase
MKLM6_RS08500	COG1132	(ABC) transporter
MKLM6_RS08630	COG0535	radical SAM domain protein
MKLM6_RS08650	COG0455	bacterial-type flagellum organization
MKLM6_RS08660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MKLM6_RS08665	COG0156	8-amino-7-oxononanoate synthase activity
MKLM6_RS08670	COG0596	Alpha beta hydrolase
MKLM6_RS08675	COG2226	methyltransferase
MKLM6_RS08680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MKLM6_RS08685	COG2703	oxygen carrier activity
MKLM6_RS08690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MKLM6_RS08695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKLM6_RS08725	COG0552	protein localization to endoplasmic reticulum
MKLM6_RS08730	COG2884	Cell division ATP-binding protein ftsE
MKLM6_RS08735	COG2177	Part of the ABC transporter FtsEX involved in
MKLM6_RS08740	COG2983	Belongs to the UPF0260 family
MKLM6_RS08755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MKLM6_RS08770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MKLM6_RS08780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKLM6_RS08785	COG1758	RNA polymerase activity
MKLM6_RS08790	COG4783	chaperone-mediated protein folding
MKLM6_RS08795	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MKLM6_RS08810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MKLM6_RS08810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MKLM6_RS08815	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MKLM6_RS08845	COG1858	cytochrome C peroxidase
MKLM6_RS08875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MKLM6_RS08880	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS08890	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS08895	COG0659	secondary active sulfate transmembrane transporter activity
MKLM6_RS08910	COG0045	succinate-CoA ligase (ADP-forming) activity
MKLM6_RS08915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MKLM6_RS08920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MKLM6_RS08975	COG1671	Belongs to the UPF0178 family
MKLM6_RS08990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MKLM6_RS08990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MKLM6_RS08990	COG0506	proline dehydrogenase activity
MKLM6_RS09010	COG0754	glutathionylspermidine amidase activity
MKLM6_RS09020	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS09025	COG2205	protein histidine kinase activity
MKLM6_RS09060	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MKLM6_RS09075	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MKLM6_RS09080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MKLM6_RS09120	COG1162	GTPase activity
MKLM6_RS09130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKLM6_RS09135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKLM6_RS09160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKLM6_RS09165	COG1047	Peptidyl-prolyl cis-trans
MKLM6_RS09175	COG5001	Diguanylate cyclase
MKLM6_RS09185	COG3344	reverse transcriptase
MKLM6_RS09190	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
MKLM6_RS09195	COG0659	secondary active sulfate transmembrane transporter activity
MKLM6_RS09200	COG1649	PFAM Uncharacterised BCR, COG1649
MKLM6_RS09200	COG0726	polysaccharide deacetylase
MKLM6_RS09205	COG1215	transferase activity, transferring glycosyl groups
MKLM6_RS09220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKLM6_RS09230	COG5016	pyruvate
MKLM6_RS09230	COG0511	ligase activity, forming carbon-carbon bonds
MKLM6_RS09235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MKLM6_RS09240	COG0297	glycogen (starch) synthase activity
MKLM6_RS09270	COG1215	transferase activity, transferring glycosyl groups
MKLM6_RS09315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MKLM6_RS09350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MKLM6_RS09395	COG0556	nucleotide-excision repair
MKLM6_RS09405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MKLM6_RS09410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKLM6_RS09420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MKLM6_RS09425	COG0039	L-malate dehydrogenase activity
MKLM6_RS09430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MKLM6_RS09435	COG0686	Belongs to the AlaDH PNT family
MKLM6_RS09455	COG1131	(ABC) transporter
MKLM6_RS09475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MKLM6_RS09480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MKLM6_RS09485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MKLM6_RS09490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MKLM6_RS09495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MKLM6_RS09500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKLM6_RS09500	COG0072	phenylalanine-tRNA ligase activity
MKLM6_RS09550	COG4178	(ABC) transporter
MKLM6_RS09570	COG2885	chlorophyll binding
MKLM6_RS09595	COG4716	Myosin-crossreactive antigen
MKLM6_RS09615	COG3459	Glycosyltransferase 36 associated
MKLM6_RS09695	COG1032	radical SAM domain protein
MKLM6_RS09700	COG2823	Periplasmic or secreted lipoprotein
MKLM6_RS09745	COG1657	PFAM Prenyltransferase squalene oxidase
MKLM6_RS09750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MKLM6_RS09795	COG3328	transposase activity
MKLM6_RS09840	COG4452	Inner membrane protein CreD
MKLM6_RS09860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKLM6_RS09865	COG1518	maintenance of DNA repeat elements
MKLM6_RS09940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MKLM6_RS09970	COG0653	protein targeting
MKLM6_RS10010	COG5002	protein histidine kinase activity
MKLM6_RS10010	COG2198	Histidine kinase
MKLM6_RS10010	COG0784	Response regulator, receiver
MKLM6_RS10015	COG0583	DNA-binding transcription factor activity
MKLM6_RS10035	COG0372	Belongs to the citrate synthase family
MKLM6_RS10040	COG5508	conserved small protein
MKLM6_RS10050	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MKLM6_RS10055	COG1053	succinate dehydrogenase
MKLM6_RS10060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKLM6_RS10065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MKLM6_RS10070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MKLM6_RS10105	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS10120	COG0840	transmembrane signaling receptor activity
MKLM6_RS10120	COG0840	transmembrane signaling receptor activity
MKLM6_RS10125	COG0835	chemotaxis
MKLM6_RS10130	COG1192	Involved in chromosome partitioning
MKLM6_RS10140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MKLM6_RS10145	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MKLM6_RS10155	COG0840	transmembrane signaling receptor activity
MKLM6_RS10170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MKLM6_RS10185	COG1199	ATP-dependent helicase activity
MKLM6_RS10190	COG1214	PFAM Peptidase M22, glycoprotease
MKLM6_RS10195	COG0009	L-threonylcarbamoyladenylate synthase
MKLM6_RS10205	COG1994	Peptidase M50
MKLM6_RS10215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MKLM6_RS10235	COG0587	DNA-directed DNA polymerase activity
MKLM6_RS10250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKLM6_RS10260	COG0463	Glycosyl transferase, family 2
MKLM6_RS10265	COG0398	Pfam SNARE associated Golgi protein
MKLM6_RS10270	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS10290	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MKLM6_RS10300	COG0840	transmembrane signaling receptor activity
MKLM6_RS10315	COG0643	Histidine kinase
MKLM6_RS10315	COG2198	Histidine kinase
MKLM6_RS10320	COG0840	transmembrane signaling receptor activity
MKLM6_RS10325	COG0835	chemotaxis
MKLM6_RS10335	COG0840	transmembrane signaling receptor activity
MKLM6_RS10340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MKLM6_RS10345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MKLM6_RS10350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MKLM6_RS10380	COG2831	hemolysin activation secretion protein
MKLM6_RS10390	COG0811	peptide transport
MKLM6_RS10440	COG0811	peptide transport
MKLM6_RS10485	COG3829	transcription factor binding
MKLM6_RS10490	COG5583	Uncharacterized small protein (DUF2292)
MKLM6_RS10500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MKLM6_RS10505	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MKLM6_RS10510	COG4208	sulfate ABC transporter
MKLM6_RS10515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MKLM6_RS10520	COG0583	DNA-binding transcription factor activity
MKLM6_RS10525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKLM6_RS10530	COG1045	serine acetyltransferase
MKLM6_RS10535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKLM6_RS10540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MKLM6_RS10550	COG3707	response regulator
MKLM6_RS10555	COG2223	nitrite transmembrane transporter activity
MKLM6_RS10560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKLM6_RS10560	COG2146	nitrite reductase [NAD(P)H] activity
MKLM6_RS10565	COG2146	nitrite reductase [NAD(P)H] activity
MKLM6_RS10620	COG0012	GTP binding
MKLM6_RS10630	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MKLM6_RS10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKLM6_RS10655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKLM6_RS10680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKLM6_RS10700	COG0436	Aminotransferase
MKLM6_RS10710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKLM6_RS10720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MKLM6_RS10730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKLM6_RS10750	COG3851	Histidine kinase
MKLM6_RS10760	COG1639	'signal transduction protein
MKLM6_RS10770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKLM6_RS10785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MKLM6_RS10795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKLM6_RS10800	COG0287	Prephenate dehydrogenase
MKLM6_RS10805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MKLM6_RS10815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MKLM6_RS10825	COG0776	regulation of translation
MKLM6_RS10840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS10845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKLM6_RS10865	COG4133	protoheme IX ABC transporter activity
MKLM6_RS10885	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MKLM6_RS10890	COG1138	Cytochrome C-type biogenesis protein
MKLM6_RS10895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKLM6_RS10930	COG1966	Carbon starvation protein
MKLM6_RS10955	COG0123	including yeast histone deacetylase and acetoin utilization protein
MKLM6_RS10980	COG0653	protein targeting
MKLM6_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
MKLM6_RS11005	COG3287	FIST C domain
MKLM6_RS11005	COG2200	EAL domain
MKLM6_RS11005	COG2199	diguanylate cyclase activity
MKLM6_RS11010	COG0243	molybdopterin cofactor binding
MKLM6_RS11015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKLM6_RS11025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKLM6_RS11025	COG1116	anion transmembrane transporter activity
MKLM6_RS11030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKLM6_RS11035	COG1116	anion transmembrane transporter activity
MKLM6_RS11035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKLM6_RS11050	COG0583	DNA-binding transcription factor activity
MKLM6_RS11055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MKLM6_RS11075	COG2223	nitrite transmembrane transporter activity
MKLM6_RS11080	COG1538	Outer membrane efflux protein
MKLM6_RS11085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MKLM6_RS11090	COG0697	spore germination
MKLM6_RS11095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKLM6_RS11100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKLM6_RS11110	COG0436	Aminotransferase
MKLM6_RS11115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKLM6_RS11130	COG1763	Mo-molybdopterin cofactor biosynthetic process
MKLM6_RS11150	COG0248	Ppx GppA phosphatase
MKLM6_RS11155	COG1131	(ABC) transporter
MKLM6_RS11160	COG0842	Transport permease protein
MKLM6_RS11165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKLM6_RS11170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MKLM6_RS11190	COG0714	Associated with various cellular activities
MKLM6_RS11225	COG0367	asparagine synthase
MKLM6_RS11255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKLM6_RS11275	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS11280	COG1215	transferase activity, transferring glycosyl groups
MKLM6_RS11295	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MKLM6_RS11295	COG0662	Cupin 2, conserved barrel domain protein
MKLM6_RS11305	COG4536	flavin adenine dinucleotide binding
MKLM6_RS11315	COG1473	amidohydrolase
MKLM6_RS11330	COG1450	Type ii and iii secretion system protein
MKLM6_RS11345	COG3166	PFAM Fimbrial assembly family protein
MKLM6_RS11350	COG3156	type II secretion system protein K
MKLM6_RS11360	COG2165	general secretion pathway protein
MKLM6_RS11365	COG4970	Tfp pilus assembly protein FimT
MKLM6_RS11375	COG1459	type II secretion system
MKLM6_RS11395	COG1058	Belongs to the CinA family
MKLM6_RS11395	COG1546	Belongs to the CinA family
MKLM6_RS11400	COG0488	(ABC) transporter
MKLM6_RS11405	COG1472	Belongs to the glycosyl hydrolase 3 family
MKLM6_RS11420	COG3344	reverse transcriptase
MKLM6_RS11430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKLM6_RS11430	COG3153	acetyltransferase
MKLM6_RS11440	COG5001	Diguanylate cyclase
MKLM6_RS11440	COG5002	protein histidine kinase activity
MKLM6_RS11450	COG4206	TonB-dependent receptor
MKLM6_RS11490	COG2132	Multicopper oxidase
MKLM6_RS11515	COG1396	sequence-specific DNA binding
MKLM6_RS11520	COG3550	peptidyl-serine autophosphorylation
MKLM6_RS11535	COG3530	Putative quorum-sensing-regulated virulence factor
MKLM6_RS11550	COG3228	Belongs to the MtfA family
MKLM6_RS11570	COG3328	transposase activity
MKLM6_RS11580	COG0582	viral genome integration into host DNA
MKLM6_RS11590	COG0436	Aminotransferase
MKLM6_RS11595	COG2925	Exonuclease
MKLM6_RS11620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MKLM6_RS11720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MKLM6_RS11750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKLM6_RS11755	COG0330	HflC and HflK could
MKLM6_RS11760	COG0330	HflC and HflK could
MKLM6_RS11780	COG1366	Belongs to the anti-sigma-factor antagonist family
MKLM6_RS11780	COG2202	Pas domain
MKLM6_RS11790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MKLM6_RS11800	COG1090	epimerase
MKLM6_RS11810	COG0415	Belongs to the DNA photolyase family
MKLM6_RS11815	COG3040	lipid binding
MKLM6_RS11830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKLM6_RS11865	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MKLM6_RS11870	COG1704	LemA family
MKLM6_RS11875	COG1136	(ABC) transporter
MKLM6_RS11885	COG0735	belongs to the Fur family
MKLM6_RS11890	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKLM6_RS11900	COG3123	guanosine phosphorylase activity
MKLM6_RS11905	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MKLM6_RS11910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MKLM6_RS11935	COG0489	protein tyrosine kinase activity
MKLM6_RS11940	COG1049	propionate catabolic process, 2-methylcitrate cycle
MKLM6_RS11950	COG0473	3-isopropylmalate dehydrogenase activity
MKLM6_RS11955	COG4555	ABC transporter
MKLM6_RS11965	COG0784	Response regulator, receiver
MKLM6_RS11965	COG2205	protein histidine kinase activity
MKLM6_RS11970	COG2197	response regulator
MKLM6_RS12035	COG0840	transmembrane signaling receptor activity
MKLM6_RS12065	COG0165	Argininosuccinate lyase
MKLM6_RS12095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MKLM6_RS12100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKLM6_RS12100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MKLM6_RS12110	COG0356	it plays a direct role in the translocation of protons across the membrane
MKLM6_RS12120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MKLM6_RS12125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MKLM6_RS12135	COG1858	cytochrome C peroxidase
MKLM6_RS12180	COG1468	defense response to virus
MKLM6_RS12180	COG1518	maintenance of DNA repeat elements
MKLM6_RS12185	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MKLM6_RS12190	COG5002	protein histidine kinase activity
MKLM6_RS12190	COG0784	Response regulator, receiver
MKLM6_RS12190	COG2205	protein histidine kinase activity
MKLM6_RS12210	COG3287	FIST C domain
MKLM6_RS12210	COG2200	EAL domain
MKLM6_RS12210	COG2199	diguanylate cyclase activity
MKLM6_RS12240	COG2091	lysine biosynthetic process via aminoadipic acid
MKLM6_RS12255	COG0577	efflux transmembrane transporter activity
MKLM6_RS12260	COG0577	efflux transmembrane transporter activity
MKLM6_RS12260	COG1136	(ABC) transporter
MKLM6_RS12290	COG2226	methyltransferase
MKLM6_RS12290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKLM6_RS12290	COG3433	isochorismatase activity
MKLM6_RS12300	COG0531	amino acid
MKLM6_RS12385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MKLM6_RS12400	COG2814	Major facilitator Superfamily
MKLM6_RS12410	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MKLM6_RS12415	COG0071	Belongs to the small heat shock protein (HSP20) family
MKLM6_RS12450	COG1472	Belongs to the glycosyl hydrolase 3 family
MKLM6_RS12455	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MKLM6_RS12460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MKLM6_RS12480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MKLM6_RS12485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKLM6_RS12495	COG5001	Diguanylate cyclase
MKLM6_RS12495	COG3706	GGDEF domain
MKLM6_RS12495	COG4251	negative regulation of phosphorylation
MKLM6_RS12495	COG2203	Gaf domain
MKLM6_RS12500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MKLM6_RS12505	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MKLM6_RS12545	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKLM6_RS12550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKLM6_RS12560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MKLM6_RS12570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKLM6_RS12575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MKLM6_RS12595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKLM6_RS12595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKLM6_RS12600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MKLM6_RS12605	COG3264	Mechanosensitive ion channel
MKLM6_RS12605	COG1511	domain protein
MKLM6_RS12635	COG1286	toxin biosynthetic process
MKLM6_RS12645	COG0285	dihydrofolate synthase activity
MKLM6_RS12650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MKLM6_RS12655	COG0159	tryptophan synthase activity
MKLM6_RS12660	COG0133	tryptophan synthase activity
MKLM6_RS12665	COG0135	phosphoribosylanthranilate isomerase activity
MKLM6_RS12675	COG1477	protein flavinylation
MKLM6_RS12680	COG1335	isochorismatase
MKLM6_RS12685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MKLM6_RS12690	COG0733	neurotransmitter:sodium symporter activity
MKLM6_RS12695	COG2867	negative regulation of translational initiation
MKLM6_RS12700	COG2914	Belongs to the UPF0125 (RnfH) family
MKLM6_RS12710	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MKLM6_RS12715	COG2835	tetraacyldisaccharide 4'-kinase activity
MKLM6_RS12715	COG1663	tetraacyldisaccharide 4'-kinase activity
MKLM6_RS12720	COG1663	tetraacyldisaccharide 4'-kinase activity
MKLM6_RS12730	COG0811	peptide transport
MKLM6_RS12740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MKLM6_RS12745	COG2890	protein-(glutamine-N5) methyltransferase activity
MKLM6_RS12785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKLM6_RS12795	COG2081	HI0933 family
MKLM6_RS12800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKLM6_RS12800	COG0574	Belongs to the PEP-utilizing enzyme family
MKLM6_RS12805	COG2203	Gaf domain
MKLM6_RS12805	COG3706	GGDEF domain
MKLM6_RS12805	COG4251	negative regulation of phosphorylation
MKLM6_RS12805	COG5001	Diguanylate cyclase
MKLM6_RS12810	COG0735	belongs to the Fur family
MKLM6_RS12815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MKLM6_RS12820	COG0351	phosphomethylpyrimidine kinase
MKLM6_RS12825	COG0352	thiamine-phosphate diphosphorylase activity
MKLM6_RS12830	COG3360	Dodecin
MKLM6_RS12840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKLM6_RS12840	COG2169	Transcriptional regulator
MKLM6_RS12850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MKLM6_RS12855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MKLM6_RS12870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MKLM6_RS12885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MKLM6_RS12890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MKLM6_RS12895	COG0583	DNA-binding transcription factor activity
MKLM6_RS12900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MKLM6_RS12910	COG0022	dehydrogenase e1 component
MKLM6_RS12910	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKLM6_RS12930	COG0742	ribosomal rna small subunit methyltransferase
MKLM6_RS12940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MKLM6_RS12955	COG0719	Fe-S assembly protein
MKLM6_RS12960	COG0396	ATPase activity
MKLM6_RS12975	COG1598	PFAM Uncharacterised protein family UPF0150
MKLM6_RS12985	COG0719	Fe-S assembly protein
MKLM6_RS12990	COG1959	2 iron, 2 sulfur cluster binding
MKLM6_RS12995	COG0726	polysaccharide deacetylase
MKLM6_RS13000	COG1215	transferase activity, transferring glycosyl groups
MKLM6_RS13010	COG3119	arylsulfatase activity
MKLM6_RS13030	COG0582	viral genome integration into host DNA
MKLM6_RS13065	COG3001	Fructosamine kinase
MKLM6_RS13075	COG0101	tRNA pseudouridine synthase activity
MKLM6_RS13085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MKLM6_RS13105	COG1959	2 iron, 2 sulfur cluster binding
MKLM6_RS13115	COG2010	Cytochrome c
MKLM6_RS13120	COG3256	nitric oxide reductase
MKLM6_RS13130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MKLM6_RS13135	COG0583	DNA-binding transcription factor activity
MKLM6_RS13140	COG3328	transposase activity
MKLM6_RS13175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKLM6_RS13180	COG2202	Pas domain
MKLM6_RS13180	COG2205	protein histidine kinase activity
MKLM6_RS13195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKLM6_RS13205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MKLM6_RS13210	COG0575	Belongs to the CDS family
MKLM6_RS13215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MKLM6_RS13220	COG0233	cytoplasmic translational termination
MKLM6_RS13225	COG0528	UMP kinase activity
MKLM6_RS13230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MKLM6_RS13235	COG0052	Belongs to the universal ribosomal protein uS2 family
MKLM6_RS13240	COG0024	Methionine aminopeptidase
MKLM6_RS13245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MKLM6_RS13250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKLM6_RS13255	COG0067	glutamate synthase
MKLM6_RS13255	COG0069	glutamate synthase activity
MKLM6_RS13255	COG0070	glutamate synthase
MKLM6_RS13260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKLM6_RS13285	COG2871	sodium ion transport
MKLM6_RS13290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MKLM6_RS13295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MKLM6_RS13300	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MKLM6_RS13310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MKLM6_RS13320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MKLM6_RS13330	COG2833	Protein of unknown function (DUF455)
MKLM6_RS13345	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MKLM6_RS13360	COG1643	Atp-dependent helicase
MKLM6_RS13375	COG4771	TonB-dependent receptor
MKLM6_RS13395	COG3300	MHYT domain
MKLM6_RS13395	COG5001	Diguanylate cyclase
MKLM6_RS13400	COG0613	PHP domain protein
MKLM6_RS13405	COG1132	(ABC) transporter
MKLM6_RS13410	COG0741	lytic transglycosylase activity
MKLM6_RS13415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MKLM6_RS13425	COG0037	tRNA processing
MKLM6_RS13430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKLM6_RS13455	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS13520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MKLM6_RS13530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKLM6_RS13535	COG0322	excinuclease ABC activity
MKLM6_RS13540	COG1573	uracil-dna glycosylase
MKLM6_RS13545	COG1185	polyribonucleotide nucleotidyltransferase activity
MKLM6_RS13550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MKLM6_RS13555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MKLM6_RS13565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MKLM6_RS13570	COG0195	Participates in both transcription termination and antitermination
MKLM6_RS13575	COG0779	Required for maturation of 30S ribosomal subunits
MKLM6_RS13590	COG0647	UMP catabolic process
MKLM6_RS13595	COG2376	Dihydroxyacetone kinase
MKLM6_RS13600	COG1461	Dihydroxyacetone kinase
MKLM6_RS13610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MKLM6_RS13615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MKLM6_RS13625	COG0129	dihydroxy-acid dehydratase activity
MKLM6_RS13640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MKLM6_RS13640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MKLM6_RS13645	COG1051	belongs to the nudix hydrolase family
MKLM6_RS13650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MKLM6_RS13655	COG0494	nUDIX hydrolase
MKLM6_RS13665	COG0425	Belongs to the sulfur carrier protein TusA family
MKLM6_RS13670	COG1648	precorrin-2 dehydrogenase activity
MKLM6_RS13670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MKLM6_RS13685	COG0137	argininosuccinate synthase activity
MKLM6_RS13690	COG1519	Transferase
MKLM6_RS13695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKLM6_RS13695	COG0574	Belongs to the PEP-utilizing enzyme family
MKLM6_RS13700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKLM6_RS13705	COG0359	binds to the 23S rRNA
MKLM6_RS13715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MKLM6_RS13720	COG0360	Binds together with S18 to 16S ribosomal RNA
MKLM6_RS13745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MKLM6_RS13780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MKLM6_RS13785	COG3321	synthase
MKLM6_RS13785	COG0604	alcohol dehydrogenase
MKLM6_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
MKLM6_RS13795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKLM6_RS13800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MKLM6_RS13805	COG0330	HflC and HflK could
MKLM6_RS13810	COG0330	HflC and HflK could
MKLM6_RS13815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKLM6_RS13820	COG1923	regulation of RNA biosynthetic process
MKLM6_RS13825	COG0488	(ABC) transporter
MKLM6_RS13830	COG0084	hydrolase, TatD family'
MKLM6_RS13835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MKLM6_RS13860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKLM6_RS13865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MKLM6_RS13870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MKLM6_RS13880	COG0802	atpase or kinase
MKLM6_RS13885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MKLM6_RS13885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MKLM6_RS13910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKLM6_RS13915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MKLM6_RS13930	COG2151	metal-sulfur cluster biosynthetic enzyme
MKLM6_RS13935	COG4221	oxidoreductase activity
MKLM6_RS13945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKLM6_RS13950	COG0402	S-adenosylhomocysteine deaminase activity
MKLM6_RS13955	COG3437	response regulator, receiver
MKLM6_RS13970	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MKLM6_RS13990	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS13995	COG2205	protein histidine kinase activity
MKLM6_RS14000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKLM6_RS14035	COG0024	Methionine aminopeptidase
MKLM6_RS14065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKLM6_RS14080	COG2205	protein histidine kinase activity
MKLM6_RS14080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKLM6_RS14095	COG3344	reverse transcriptase
MKLM6_RS14100	COG0625	glutathione transferase activity
MKLM6_RS14135	COG0277	FAD linked oxidase domain protein
MKLM6_RS14140	COG0277	FAD linked oxidase domain protein
MKLM6_RS14145	COG0247	lactate metabolic process
MKLM6_RS14150	COG3240	lipase activity
MKLM6_RS14190	COG4191	Histidine kinase
MKLM6_RS14190	COG0784	Response regulator, receiver
MKLM6_RS14205	COG4302	ethanolamine ammonia-lyase activity
MKLM6_RS14210	COG4303	Ethanolamine ammonia lyase large subunit
MKLM6_RS14215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKLM6_RS14225	COG0475	glutathione-regulated potassium exporter activity
MKLM6_RS14225	COG0569	domain protein
MKLM6_RS14230	COG3189	MarR family transcriptional regulator
MKLM6_RS14265	COG5002	protein histidine kinase activity
MKLM6_RS14265	COG0784	Response regulator, receiver
MKLM6_RS14265	COG2205	protein histidine kinase activity
MKLM6_RS14300	COG3604	Transcriptional regulator
MKLM6_RS14310	COG3220	belongs to the UPF0276 family
MKLM6_RS14330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MKLM6_RS14335	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MKLM6_RS14345	COG1490	D-aminoacyl-tRNA deacylase activity
MKLM6_RS14380	COG2204	response regulator
MKLM6_RS14385	COG3852	Histidine kinase
MKLM6_RS14415	COG0789	Transcriptional regulator
MKLM6_RS14425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS14450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MKLM6_RS14460	COG3328	transposase activity
MKLM6_RS14490	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MKLM6_RS14510	COG0659	secondary active sulfate transmembrane transporter activity
MKLM6_RS14520	COG3002	Belongs to the UPF0753 family
MKLM6_RS14525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKLM6_RS14540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MKLM6_RS14545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKLM6_RS14550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MKLM6_RS14555	COG0542	response to heat
MKLM6_RS14560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MKLM6_RS14570	COG0482	sulfurtransferase activity
MKLM6_RS14575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MKLM6_RS14590	COG0281	malic enzyme
MKLM6_RS14595	COG2715	membrane protein required for spore maturation
MKLM6_RS14600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKLM6_RS14635	COG5001	Diguanylate cyclase
MKLM6_RS14645	COG1355	regulation of microtubule-based process
MKLM6_RS14655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKLM6_RS14660	COG0363	glucosamine-6-phosphate deaminase activity
MKLM6_RS14670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MKLM6_RS14675	COG0800	Aldolase
MKLM6_RS14695	COG4269	membrane
MKLM6_RS14710	COG3852	Histidine kinase
MKLM6_RS14715	COG2204	response regulator
MKLM6_RS14720	COG5001	Diguanylate cyclase
MKLM6_RS14725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKLM6_RS14730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MKLM6_RS14755	COG0513	Belongs to the DEAD box helicase family
MKLM6_RS14765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MKLM6_RS14775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MKLM6_RS14780	COG0484	heat shock protein binding
MKLM6_RS14805	COG0443	Heat shock 70 kDa protein
MKLM6_RS14810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MKLM6_RS14815	COG1420	regulation of RNA biosynthetic process
MKLM6_RS14830	COG4191	Histidine kinase
MKLM6_RS14865	COG0386	Belongs to the glutathione peroxidase family
MKLM6_RS14880	COG0799	negative regulation of ribosome biogenesis
MKLM6_RS14885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MKLM6_RS14890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MKLM6_RS14905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MKLM6_RS14910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKLM6_RS14915	COG2863	cytochrome
MKLM6_RS14935	COG0483	inositol monophosphate 1-phosphatase activity
MKLM6_RS14940	COG0004	ammonium transporteR
MKLM6_RS14945	COG0347	Belongs to the P(II) protein family
MKLM6_RS14950	COG0004	ammonium transporteR
MKLM6_RS14965	COG0174	glutamine synthetase
MKLM6_RS14975	COG3852	Histidine kinase
MKLM6_RS14980	COG2204	response regulator
MKLM6_RS15000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MKLM6_RS15005	COG2824	Alkylphosphonate utilization operon protein PhnA
MKLM6_RS15015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MKLM6_RS15020	COG0058	SHG alpha-glucan phosphorylase activity
MKLM6_RS15025	COG0653	protein targeting
MKLM6_RS15030	COG0569	domain protein
MKLM6_RS15050	COG3622	Belongs to the hyi family
MKLM6_RS15055	COG2084	Dehydrogenase
MKLM6_RS15065	COG4772	TonB-dependent receptor
MKLM6_RS15070	COG2827	Endonuclease containing a URI domain
MKLM6_RS15080	COG0328	RNA-DNA hybrid ribonuclease activity
MKLM6_RS15085	COG2226	methyltransferase
MKLM6_RS15090	COG0741	lytic transglycosylase activity
MKLM6_RS15090	COG1388	LysM domain
MKLM6_RS15120	COG2914	Belongs to the UPF0125 (RnfH) family
MKLM6_RS15135	COG4658	electron transport chain
MKLM6_RS15140	COG4656	Part of a membrane complex involved in electron transport
MKLM6_RS15145	COG2878	Part of a membrane complex involved in electron transport
MKLM6_RS15150	COG4657	Part of a membrane complex involved in electron transport
MKLM6_RS15170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MKLM6_RS15175	COG3404	Formiminotransferase-cyclodeaminase
MKLM6_RS15180	COG0215	cysteine-tRNA ligase activity
MKLM6_RS15195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKLM6_RS15200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKLM6_RS15205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKLM6_RS15235	COG1136	(ABC) transporter
MKLM6_RS15255	COG0529	Catalyzes the synthesis of activated sulfate
MKLM6_RS15265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKLM6_RS15275	COG0151	Belongs to the GarS family
MKLM6_RS15280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MKLM6_RS15295	COG2183	response to ionizing radiation
MKLM6_RS15305	COG0419	ATPase involved in DNA repair
MKLM6_RS15330	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS15335	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS15350	COG0367	asparagine synthase
MKLM6_RS15355	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS15390	COG0489	protein tyrosine kinase activity
MKLM6_RS15420	COG4191	Histidine kinase
MKLM6_RS15425	COG2204	response regulator
MKLM6_RS15450	COG2308	Evidence 4 Homologs of previously reported genes of
MKLM6_RS15465	COG1566	PFAM secretion protein HlyD family protein
MKLM6_RS15470	COG1538	Outer membrane efflux protein
MKLM6_RS15485	COG0583	DNA-binding transcription factor activity
MKLM6_RS15505	COG1686	Belongs to the peptidase S11 family
MKLM6_RS15515	COG2921	Belongs to the UPF0250 family
MKLM6_RS15520	COG0321	lipoyl(octanoyl) transferase activity
MKLM6_RS15525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MKLM6_RS15560	COG0514	ATP-dependent DNA helicase (RecQ)
MKLM6_RS15565	COG2918	glutathione biosynthetic process
MKLM6_RS15595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKLM6_RS15625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKLM6_RS15630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKLM6_RS15635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MKLM6_RS15645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKLM6_RS15650	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKLM6_RS15660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKLM6_RS15665	COG0557	exoribonuclease II activity
MKLM6_RS15695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MKLM6_RS15700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKLM6_RS15705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MKLM6_RS15710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKLM6_RS15715	COG0826	peptidase U32
MKLM6_RS15730	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS15800	COG1132	(ABC) transporter
MKLM6_RS15810	COG1215	transferase activity, transferring glycosyl groups
MKLM6_RS15820	COG2089	acid synthase
MKLM6_RS15840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MKLM6_RS15845	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MKLM6_RS15855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MKLM6_RS15860	COG1086	Polysaccharide biosynthesis protein
MKLM6_RS15905	COG0326	Molecular chaperone. Has ATPase activity
MKLM6_RS15925	COG1943	Transposase
MKLM6_RS15945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MKLM6_RS15950	COG0497	DNA recombination
MKLM6_RS15955	COG0697	spore germination
MKLM6_RS15995	COG3328	transposase activity
MKLM6_RS16005	COG0438	transferase activity, transferring glycosyl groups
MKLM6_RS16050	COG4191	Histidine kinase
MKLM6_RS16065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MKLM6_RS16065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MKLM6_RS16065	COG0674	pyruvate-flavodoxin oxidoreductase activity
MKLM6_RS16065	COG1013	pyruvate-flavodoxin oxidoreductase activity
MKLM6_RS16090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MKLM6_RS16105	COG1943	Transposase
MKLM6_RS16120	COG1773	rubredoxin
MKLM6_RS16130	COG0330	HflC and HflK could
MKLM6_RS16135	COG0330	HflC and HflK could
MKLM6_RS16145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKLM6_RS16165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
MKLM6_RS16180	COG1733	regulation of RNA biosynthetic process
MKLM6_RS16225	COG0714	Associated with various cellular activities
MKLM6_RS16235	COG2010	Cytochrome c
MKLM6_RS16240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKLM6_RS16245	COG4993	Dehydrogenase
MKLM6_RS16280	COG3328	transposase activity
MKLM6_RS16285	COG0582	viral genome integration into host DNA
MKLM6_RS16365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MKLM6_RS16390	COG0242	peptide deformylase activity
MKLM6_RS16400	COG0316	Belongs to the HesB IscA family
MKLM6_RS16410	COG1959	2 iron, 2 sulfur cluster binding
MKLM6_RS16415	COG1045	serine acetyltransferase
MKLM6_RS16430	COG0702	epimerase
MKLM6_RS16435	COG0702	epimerase
MKLM6_RS16445	COG0442	prolyl-tRNA aminoacylation
MKLM6_RS16460	COG1466	dna polymerase III delta subunit
MKLM6_RS16465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MKLM6_RS16470	COG0495	leucyl-tRNA aminoacylation
MKLM6_RS16500	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKLM6_RS16535	COG2217	Heavy metal translocating P-type atpase
MKLM6_RS16535	COG2608	mercury ion transmembrane transporter activity
MKLM6_RS16540	COG2217	Heavy metal translocating P-type atpase
MKLM6_RS16545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MKLM6_RS16555	COG2915	High frequency lysogenization protein hflD homolog
MKLM6_RS16560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MKLM6_RS16585	COG0628	permease
MKLM6_RS16590	COG0586	Pfam SNARE associated Golgi protein
MKLM6_RS16595	COG1278	Cold shock
MKLM6_RS16630	COG1674	ftsk spoiiie
MKLM6_RS16635	COG0492	ferredoxin-NADP+ reductase activity
MKLM6_RS16645	COG1136	(ABC) transporter
MKLM6_RS16650	COG2177	Part of the ABC transporter FtsEX involved in
MKLM6_RS16705	COG1858	cytochrome C peroxidase
MKLM6_RS16730	COG1858	cytochrome C peroxidase
MKLM6_RS16745	COG3383	formate dehydrogenase (NAD+) activity
MKLM6_RS16770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKLM6_RS16775	COG4174	ABC transporter (Permease)
MKLM6_RS16785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKLM6_RS16800	COG0776	regulation of translation
MKLM6_RS16805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MKLM6_RS16810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MKLM6_RS16815	COG0740	serine-type endopeptidase activity
MKLM6_RS16820	COG0544	peptidyl-prolyl cis-trans isomerase activity
MKLM6_RS16840	COG2922	Belongs to the Smg family
MKLM6_RS16845	COG0758	DNA mediated transformation
MKLM6_RS16850	COG1652	LysM domain
MKLM6_RS16855	COG0242	peptide deformylase activity
MKLM6_RS16860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MKLM6_RS16875	COG5000	phosphorelay sensor kinase activity
MKLM6_RS16880	COG2204	response regulator
MKLM6_RS16885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MKLM6_RS16890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MKLM6_RS16900	COG0028	Belongs to the TPP enzyme family
MKLM6_RS16910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MKLM6_RS16920	COG1183	phosphatidylcholine synthase activity
MKLM6_RS16950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKLM6_RS16965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS16975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKLM6_RS16980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKLM6_RS16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS16990	COG1136	(ABC) transporter
MKLM6_RS16990	COG0577	efflux transmembrane transporter activity
MKLM6_RS17020	COG0633	Ferredoxin
MKLM6_RS17025	COG0426	domain, Protein
MKLM6_RS17115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKLM6_RS17120	COG1459	type II secretion system
MKLM6_RS17130	COG0842	Transport permease protein
MKLM6_RS17135	COG0842	Transport permease protein
MKLM6_RS17140	COG1131	(ABC) transporter
MKLM6_RS17150	COG1917	Cupin 2, conserved barrel domain protein
MKLM6_RS17150	COG2169	Transcriptional regulator
MKLM6_RS17155	COG4106	trans-aconitate 2-methyltransferase activity
MKLM6_RS17220	COG2308	Evidence 4 Homologs of previously reported genes of
MKLM6_RS17220	COG2307	Protein conserved in bacteria
MKLM6_RS17240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MKLM6_RS17250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MKLM6_RS17255	COG3383	formate dehydrogenase (NAD+) activity
MKLM6_RS17260	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
MKLM6_RS17265	COG3259	Nickel-dependent hydrogenase
MKLM6_RS17290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKLM6_RS17295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKLM6_RS17305	COG0318	PFAM AMP-dependent synthetase and ligase
MKLM6_RS17310	COG1216	Glycosyl transferase, family 2
MKLM6_RS17325	COG2986	histidine ammonia-lyase
MKLM6_RS17370	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MKLM6_RS17435	COG4585	Histidine kinase
MKLM6_RS17450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKLM6_RS17460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKLM6_RS17460	COG0116	Belongs to the methyltransferase superfamily
MKLM6_RS17490	COG2072	flavoprotein involved in K transport
MKLM6_RS17500	COG0456	acetyltransferase
MKLM6_RS17500	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MKLM6_RS17530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKLM6_RS17540	COG0798	PFAM Bile acid sodium symporter
MKLM6_RS17550	COG2217	Heavy metal translocating P-type atpase
MKLM6_RS17575	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MKLM6_RS17610	COG2917	probably involved in intracellular septation
MKLM6_RS17615	COG2350	Protein conserved in bacteria
MKLM6_RS17620	COG0271	Belongs to the BolA IbaG family
MKLM6_RS17625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKLM6_RS17645	COG3383	formate dehydrogenase (NAD+) activity
MKLM6_RS17650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MKLM6_RS17665	COG2205	protein histidine kinase activity
MKLM6_RS17670	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS17685	COG0439	Biotin carboxylase
MKLM6_RS17700	COG1116	anion transmembrane transporter activity
MKLM6_RS17725	COG1132	(ABC) transporter
MKLM6_RS17755	COG1487	ribonuclease activity
MKLM6_RS17925	COG1566	PFAM secretion protein HlyD family protein
MKLM6_RS17950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MKLM6_RS17955	COG0706	membrane insertase activity
MKLM6_RS17965	COG0594	ribonuclease P activity
MKLM6_RS17970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MKLM6_RS17980	COG0306	phosphate transporter
MKLM6_RS17995	COG2969	positive regulation of protein catabolic process
MKLM6_RS18015	COG1334	flagellar protein FlaG
MKLM6_RS18025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MKLM6_RS18035	COG2089	acid synthase
MKLM6_RS18055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKLM6_RS18065	COG1088	dTDP-glucose 4,6-dehydratase activity
MKLM6_RS18070	COG1083	cytidylyl-transferase
MKLM6_RS18075	COG0443	Heat shock 70 kDa protein
MKLM6_RS18085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS18115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MKLM6_RS18120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MKLM6_RS18130	COG0513	Belongs to the DEAD box helicase family
MKLM6_RS18140	COG1278	Cold shock
MKLM6_RS18170	COG1012	belongs to the aldehyde dehydrogenase family
MKLM6_RS18175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKLM6_RS18185	COG0625	glutathione transferase activity
MKLM6_RS18210	COG0584	glycerophosphoryl diester phosphodiesterase
MKLM6_RS18215	COG4941	Belongs to the sigma-70 factor family
MKLM6_RS18220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKLM6_RS18270	COG0175	sulfate reduction
MKLM6_RS18300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKLM6_RS18315	COG0202	RNA polymerase activity
MKLM6_RS18320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MKLM6_RS18325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MKLM6_RS18335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MKLM6_RS18340	COG0201	protein transport
MKLM6_RS18345	COG0200	Binds to the 23S rRNA
MKLM6_RS18350	COG1841	ribosomal large subunit assembly
MKLM6_RS18355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MKLM6_RS18360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MKLM6_RS18365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MKLM6_RS18370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MKLM6_RS18375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MKLM6_RS18385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MKLM6_RS18390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MKLM6_RS18395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MKLM6_RS18400	COG0255	Belongs to the universal ribosomal protein uL29 family
MKLM6_RS18405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MKLM6_RS18410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MKLM6_RS18415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MKLM6_RS18420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MKLM6_RS18425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MKLM6_RS18430	COG0089	rRNA binding
MKLM6_RS18435	COG0088	Forms part of the polypeptide exit tunnel
MKLM6_RS18440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MKLM6_RS18445	COG0051	transcription antitermination factor activity, RNA binding
MKLM6_RS18450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MKLM6_RS18455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKLM6_RS18460	COG0049	tRNA binding
MKLM6_RS18470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MKLM6_RS18475	COG0085	RNA polymerase activity
MKLM6_RS18480	COG0222	ribosome binding
MKLM6_RS18485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MKLM6_RS18490	COG0081	regulation of translation
MKLM6_RS18495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MKLM6_RS18505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKLM6_RS18515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MKLM6_RS18535	COG0193	aminoacyl-tRNA hydrolase activity
MKLM6_RS18540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MKLM6_RS18545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MKLM6_RS18555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MKLM6_RS18570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MKLM6_RS18575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MKLM6_RS18580	COG2890	protein-(glutamine-N5) methyltransferase activity
MKLM6_RS18590	COG2204	response regulator
MKLM6_RS18595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKLM6_RS18600	COG3852	Histidine kinase
MKLM6_RS18610	COG1639	'signal transduction protein
MKLM6_RS18615	COG5001	Diguanylate cyclase
MKLM6_RS18615	COG5002	protein histidine kinase activity
MKLM6_RS18635	COG0045	succinate-CoA ligase (ADP-forming) activity
MKLM6_RS18640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MKLM6_RS18645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MKLM6_RS18645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKLM6_RS18685	COG1686	Belongs to the peptidase S11 family
MKLM6_RS18690	COG2900	Belongs to the SlyX family
MKLM6_RS18705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MKLM6_RS18710	COG0590	tRNA wobble adenosine to inosine editing
MKLM6_RS18720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MKLM6_RS18770	COG0835	chemotaxis
MKLM6_RS18770	COG0784	Response regulator, receiver
MKLM6_RS18780	COG1815	bacterial-type flagellum-dependent cell motility
MKLM6_RS18790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MKLM6_RS18795	COG1749	Flagellar hook protein flgE
MKLM6_RS18800	COG4787	bacterial-type flagellum-dependent cell motility
MKLM6_RS18805	COG4786	Flagellar basal body rod
MKLM6_RS18815	COG1706	bacterial-type flagellum-dependent cell motility
MKLM6_RS18825	COG1256	bacterial-type flagellum assembly
MKLM6_RS18830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKLM6_RS18845	COG2951	lytic endotransglycosylase activity
MKLM6_RS18850	COG0772	Belongs to the SEDS family
MKLM6_RS18855	COG0768	penicillin binding
MKLM6_RS18860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MKLM6_RS18865	COG1792	Involved in formation and maintenance of cell shape
MKLM6_RS18870	COG1077	Cell shape determining protein MreB Mrl
MKLM6_RS18875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKLM6_RS18880	COG0154	amidase activity
MKLM6_RS18890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKLM6_RS18895	COG3391	amine dehydrogenase activity
MKLM6_RS18915	COG0717	Belongs to the dCTP deaminase family
MKLM6_RS18925	COG0837	glucose binding
MKLM6_RS18965	COG0840	transmembrane signaling receptor activity
MKLM6_RS18970	COG1215	transferase activity, transferring glycosyl groups
MKLM6_RS19010	COG2204	response regulator
MKLM6_RS19035	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MKLM6_RS19040	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MKLM6_RS19065	COG0583	DNA-binding transcription factor activity
MKLM6_RS19080	COG1294	oxidase, subunit
MKLM6_RS19105	COG2132	Multicopper oxidase
MKLM6_RS19120	COG2204	response regulator
MKLM6_RS19125	COG0739	heme binding
MKLM6_RS19125	COG0741	lytic transglycosylase activity
MKLM6_RS19125	COG1196	nuclear chromosome segregation
MKLM6_RS19130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MKLM6_RS19170	COG2271	Major facilitator Superfamily
MKLM6_RS19205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKLM6_RS19210	COG0305	Participates in initiation and elongation during chromosome replication
MKLM6_RS19215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKLM6_RS19230	COG0309	Hydrogenase expression formation protein (HypE)
MKLM6_RS19235	COG3328	transposase activity
MKLM6_RS19260	COG2095	MarC family integral membrane protein
MKLM6_RS19275	COG3002	Belongs to the UPF0753 family
MKLM6_RS19280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKLM6_RS19290	COG0409	Hydrogenase expression formation protein
MKLM6_RS19315	COG0375	protein maturation
MKLM6_RS19345	COG3267	Type II secretory pathway component ExeA
MKLM6_RS19345	COG3409	Peptidoglycan-binding domain 1 protein
MKLM6_RS19350	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MKLM6_RS19365	COG3956	TIGRFAM MazG family protein
MKLM6_RS19370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKLM6_RS19375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MKLM6_RS19380	COG0509	glycine decarboxylation via glycine cleavage system
MKLM6_RS19400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKLM6_RS19405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKLM6_RS19410	COG0493	'glutamate synthase
MKLM6_RS19410	COG0543	2 iron, 2 sulfur cluster binding
MKLM6_RS19415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKLM6_RS19420	COG1278	Cold shock
MKLM6_RS19425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKLM6_RS19430	COG2920	part of a sulfur-relay system
MKLM6_RS19440	COG2076	Multidrug Resistance protein
MKLM6_RS19445	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MKLM6_RS19450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKLM6_RS19460	COG1715	Restriction endonuclease
MKLM6_RS19490	COG2346	COG2346, Truncated hemoglobins
MKLM6_RS19495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MKLM6_RS19500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MKLM6_RS19505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MKLM6_RS19510	COG0501	Belongs to the peptidase M48B family
MKLM6_RS19515	COG1162	GTPase activity
MKLM6_RS19520	COG0022	dehydrogenase e1 component
MKLM6_RS19545	COG0537	adenosine 5'-monophosphoramidase activity
MKLM6_RS19550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MKLM6_RS19555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MKLM6_RS19560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKLM6_RS19570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MKLM6_RS19570	COG0616	signal peptide processing
MKLM6_RS19575	COG0546	phosphoglycolate phosphatase activity
MKLM6_RS19580	COG0564	pseudouridine synthase activity
MKLM6_RS19585	COG1530	ribonuclease E activity
MKLM6_RS19590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKLM6_RS19595	COG2957	Belongs to the agmatine deiminase family
MKLM6_RS19600	COG4206	TonB-dependent receptor
MKLM6_RS19625	COG1254	Belongs to the acylphosphatase family
MKLM6_RS19630	COG0116	Belongs to the methyltransferase superfamily
MKLM6_RS19630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKLM6_RS19645	COG0840	transmembrane signaling receptor activity
MKLM6_RS19645	COG3290	protein histidine kinase activity
MKLM6_RS19655	COG0745	RESPONSE REGULATOR receiver
MKLM6_RS19665	COG0525	valine-tRNA ligase activity
MKLM6_RS19705	COG0166	Belongs to the GPI family
MKLM6_RS19740	COG2205	protein histidine kinase activity
MKLM6_RS19750	COG1943	Transposase
MKLM6_RS19765	COG3046	protein related to deoxyribodipyrimidine photolyase
MKLM6_RS19775	COG0415	Belongs to the DNA photolyase family
MKLM6_RS19785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKLM6_RS19805	COG0009	L-threonylcarbamoyladenylate synthase
MKLM6_RS19810	COG5016	pyruvate
MKLM6_RS19810	COG0511	ligase activity, forming carbon-carbon bonds
MKLM6_RS19815	COG0439	Biotin carboxylase
MKLM6_RS19840	COG4181	ATPase activity
MKLM6_RS19875	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MKLM6_RS19880	COG2894	cell division
MKLM6_RS19885	COG0850	regulation of cytokinetic process
MKLM6_RS19890	COG2239	Acts as a magnesium transporter
MKLM6_RS19895	COG1660	Displays ATPase and GTPase activities
MKLM6_RS19905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MKLM6_RS19910	COG1137	ATPase activity
MKLM6_RS19915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MKLM6_RS19925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MKLM6_RS19935	COG1127	ABC transporter
MKLM6_RS19940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MKLM6_RS19945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MKLM6_RS19955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKLM6_RS19960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MKLM6_RS19965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MKLM6_RS19970	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKLM6_RS19975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MKLM6_RS19990	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MKLM6_RS20000	COG5001	Diguanylate cyclase
MKLM6_RS20030	COG1765	OsmC-like protein
MKLM6_RS20035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MKLM6_RS20045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MKLM6_RS20050	COG2967	ApaG domain
MKLM6_RS20060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKLM6_RS20105	COG0457	Tetratricopeptide repeat
MKLM6_RS20105	COG0515	serine threonine protein kinase
MKLM6_RS20110	COG0791	NLP P60 protein
MKLM6_RS20130	COG0778	Nitroreductase
MKLM6_RS20140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKLM6_RS20145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MKLM6_RS20160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MKLM6_RS20165	COG4221	oxidoreductase activity
MKLM6_RS20190	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MKLM6_RS20200	COG0196	riboflavin kinase activity
MKLM6_RS20225	COG0625	glutathione transferase activity
MKLM6_RS20230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MKLM6_RS20305	COG0631	protein serine/threonine phosphatase activity
MKLM6_RS20385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MKLM6_RS20390	COG0019	diaminopimelate decarboxylase activity
MKLM6_RS20425	COG0254	rRNA binding
MKLM6_RS20435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKLM6_RS20440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKLM6_RS20450	COG0793	Belongs to the peptidase S41A family
MKLM6_RS20455	COG4942	peptidase
MKLM6_RS20460	COG0640	Transcriptional regulator
MKLM6_RS20470	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MKLM6_RS20475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MKLM6_RS20480	COG2001	Belongs to the MraZ family
MKLM6_RS20505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MKLM6_RS20510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKLM6_RS20515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MKLM6_RS20520	COG0772	Belongs to the SEDS family
MKLM6_RS20525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MKLM6_RS20530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKLM6_RS20535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MKLM6_RS20540	COG1181	Belongs to the D-alanine--D-alanine ligase family
MKLM6_RS20545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MKLM6_RS20555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MKLM6_RS20560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MKLM6_RS20575	COG0463	Glycosyl transferase, family 2
MKLM6_RS20590	COG0531	amino acid
MKLM6_RS20615	COG2084	Dehydrogenase
MKLM6_RS20620	COG1166	arginine decarboxylase activity
MKLM6_RS20625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MKLM6_RS20660	COG1136	(ABC) transporter
MKLM6_RS20660	COG0577	efflux transmembrane transporter activity
MKLM6_RS20665	COG0577	efflux transmembrane transporter activity
MKLM6_RS20665	COG1136	(ABC) transporter
MKLM6_RS20685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKLM6_RS20710	COG0538	isocitrate dehydrogenase activity
MKLM6_RS20735	COG2960	long-chain fatty acid transporting porin activity
MKLM6_RS20740	COG0606	chelatase, subunit chli
MKLM6_RS20755	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MKLM6_RS20755	COG3608	succinylglutamate desuccinylase aspartoacylase
MKLM6_RS20765	COG0450	alkyl hydroperoxide reductase
MKLM6_RS20795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKLM6_RS20805	COG2201	protein-glutamate methylesterase activity
MKLM6_RS20810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MKLM6_RS20825	COG0840	transmembrane signaling receptor activity
MKLM6_RS20830	COG0643	Histidine kinase
MKLM6_RS20830	COG2198	Histidine kinase
MKLM6_RS20840	COG2201	protein-glutamate methylesterase activity
MKLM6_RS20855	COG3219	Protein conserved in bacteria
MKLM6_RS20860	COG3220	belongs to the UPF0276 family
MKLM6_RS20875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKLM6_RS20885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MKLM6_RS20950	COG0673	inositol 2-dehydrogenase activity
MKLM6_RS20975	COG1595	DNA-templated transcription, initiation
MKLM6_RS20985	COG3712	iron ion homeostasis
MKLM6_RS20990	COG1595	DNA-templated transcription, initiation
MKLM6_RS21035	COG4774	siderophore transport
MKLM6_RS21050	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MKLM6_RS21055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MKLM6_RS21065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MKLM6_RS21075	COG0617	tRNA 3'-terminal CCA addition
MKLM6_RS21100	COG0795	lipopolysaccharide-transporting ATPase activity
MKLM6_RS21105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MKLM6_RS21120	COG0235	Class ii aldolase
MKLM6_RS21125	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MKLM6_RS21130	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
MKLM6_RS21135	COG0189	ligase activity
MKLM6_RS21155	COG3158	transport of potassium into the cell
MKLM6_RS21185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKLM6_RS21190	COG1573	uracil-dna glycosylase
MKLM6_RS21195	COG0708	Exodeoxyribonuclease III
MKLM6_RS21250	COG0811	peptide transport
MKLM6_RS21325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKLM6_RS21330	COG3028	Belongs to the UPF0307 family
MKLM6_RS21340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MKLM6_RS21345	COG0792	nuclease activity
MKLM6_RS21350	COG3107	peptidoglycan biosynthetic process
MKLM6_RS21355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MKLM6_RS21365	COG3122	Protein conserved in bacteria
MKLM6_RS21395	COG4636	protein conserved in cyanobacteria
MKLM6_RS21410	COG0702	epimerase
MKLM6_RS21425	COG5001	Diguanylate cyclase
MKLM6_RS21425	COG4251	negative regulation of phosphorylation
MKLM6_RS21425	COG3706	GGDEF domain
MKLM6_RS21425	COG2203	Gaf domain
MKLM6_RS21435	COG1252	NADH dehydrogenase
MKLM6_RS21445	COG3328	transposase activity
MKLM6_RS21460	COG0033	Phosphoglucomutase
MKLM6_RS21475	COG1376	ErfK ybiS ycfS ynhG family protein
MKLM6_RS21480	COG2974	May be involved in recombination
MKLM6_RS21495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MKLM6_RS21505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKLM6_RS21510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MKLM6_RS21560	COG4771	TonB-dependent receptor
MKLM6_RS21570	COG2205	protein histidine kinase activity
MKLM6_RS21575	COG0704	Plays a role in the regulation of phosphate uptake
MKLM6_RS21580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKLM6_RS21585	COG0581	inorganic phosphate transmembrane transporter activity
MKLM6_RS21605	COG0252	asparaginase activity
MKLM6_RS21620	COG0018	arginyl-trna synthetase
MKLM6_RS21630	COG0805	protein transport
MKLM6_RS21635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKLM6_RS21640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKLM6_RS21645	COG0140	phosphoribosyl-ATP diphosphatase activity
MKLM6_RS21650	COG0583	DNA-binding transcription factor activity
MKLM6_RS21665	COG1217	gtp-binding protein TYPA
MKLM6_RS21670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKLM6_RS21670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MKLM6_RS21675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MKLM6_RS21690	COG0730	response to heat
MKLM6_RS21755	COG4942	peptidase
MKLM6_RS21760	COG1322	Protein conserved in bacteria
MKLM6_RS21780	COG1760	l-serine dehydratase
MKLM6_RS21800	COG0187	DNA topoisomerase II activity
MKLM6_RS21835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MKLM6_RS21845	COG1882	Formate acetyltransferase
MKLM6_RS21865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKLM6_RS21865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKLM6_RS21870	COG2878	Part of a membrane complex involved in electron transport
MKLM6_RS21880	COG4974	Belongs to the 'phage' integrase family
MKLM6_RS21910	COG2951	lytic endotransglycosylase activity
MKLM6_RS21925	COG4260	virion core protein, lumpy skin disease virus
MKLM6_RS21935	COG3795	YCII-related domain
MKLM6_RS21965	COG0631	protein serine/threonine phosphatase activity
MKLM6_RS21970	COG1716	ATPase activity
MKLM6_RS21975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MKLM6_RS22020	COG2003	Belongs to the UPF0758 family
MKLM6_RS22125	COG0583	DNA-binding transcription factor activity
MKLM6_RS22170	COG1475	DNA binding
MKLM6_RS22225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MKLM6_RS22290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MKLM6_RS22305	COG4804	nuclease activity
MKLM6_RS22320	COG0420	3'-5' exonuclease activity
MKLM6_RS22340	COG2336	PFAM SpoVT AbrB
MKLM6_RS22355	COG1696	Membrane protein involved in D-alanine export
MKLM6_RS22365	COG1525	nuclease
MKLM6_RS22435	COG3209	COG3209 Rhs family protein
MKLM6_RS22485	COG0741	lytic transglycosylase activity
MKLM6_RS22615	COG3209	COG3209 Rhs family protein
MKLM6_RS22625	COG3209	COG3209 Rhs family protein
MKLM6_RS22645	COG3012	SEC-C Motif Domain Protein
MKLM6_RS22675	COG0583	DNA-binding transcription factor activity
MKLM6_RS22725	COG2135	peptidase activity
MKLM6_RS22745	COG1192	Involved in chromosome partitioning