locus-tag	class	description
F1E05_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1E05_RS00020	COG1968	undecaprenyl-diphosphatase activity
F1E05_RS00025	COG2954	triphosphatase activity
F1E05_RS00045	COG3220	belongs to the UPF0276 family
F1E05_RS00055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1E05_RS00070	COG2878	Part of a membrane complex involved in electron transport
F1E05_RS00075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1E05_RS00075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1E05_RS00080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1E05_RS00085	COG0066	3-isopropylmalate dehydratase activity
F1E05_RS00095	COG0473	3-isopropylmalate dehydrogenase activity
F1E05_RS00115	COG1988	membrane-bound metal-dependent
F1E05_RS00170	COG1252	NADH dehydrogenase
F1E05_RS00180	COG1196	nuclear chromosome segregation
F1E05_RS00195	COG2104	thiamine diphosphate biosynthetic process
F1E05_RS00195	COG2022	thiamine diphosphate biosynthetic process
F1E05_RS00200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F1E05_RS00215	COG0450	alkyl hydroperoxide reductase
F1E05_RS00220	COG3023	N-Acetylmuramoyl-L-alanine amidase
F1E05_RS00225	COG0515	serine threonine protein kinase
F1E05_RS00225	COG2815	serine threonine protein kinase
F1E05_RS00230	COG1561	YicC-like family, N-terminal region
F1E05_RS00245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1E05_RS00255	COG2226	methyltransferase
F1E05_RS00275	COG0009	L-threonylcarbamoyladenylate synthase
F1E05_RS00280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F1E05_RS00290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1E05_RS00295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1E05_RS00300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1E05_RS00360	COG1360	Flagellar Motor Protein
F1E05_RS00370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1E05_RS00375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1E05_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1E05_RS00390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F1E05_RS00395	COG1649	PFAM Uncharacterised BCR, COG1649
F1E05_RS00395	COG0726	polysaccharide deacetylase
F1E05_RS00400	COG1215	transferase activity, transferring glycosyl groups
F1E05_RS00410	COG2205	protein histidine kinase activity
F1E05_RS00415	COG0745	RESPONSE REGULATOR receiver
F1E05_RS00455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F1E05_RS00460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1E05_RS00470	COG3550	peptidyl-serine autophosphorylation
F1E05_RS00475	COG1396	sequence-specific DNA binding
F1E05_RS00500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F1E05_RS00535	COG0187	DNA topoisomerase II activity
F1E05_RS00540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F1E05_RS00560	COG0625	glutathione transferase activity
F1E05_RS00565	COG1254	Belongs to the acylphosphatase family
F1E05_RS00570	COG0116	Belongs to the methyltransferase superfamily
F1E05_RS00570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F1E05_RS00590	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1E05_RS00595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F1E05_RS00600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F1E05_RS00610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1E05_RS00615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F1E05_RS00625	COG0531	amino acid
F1E05_RS00640	COG3852	Histidine kinase
F1E05_RS00730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F1E05_RS00740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F1E05_RS00745	COG0019	diaminopimelate decarboxylase activity
F1E05_RS00750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F1E05_RS00760	COG1666	GTP binding
F1E05_RS00770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F1E05_RS00775	COG1253	flavin adenine dinucleotide binding
F1E05_RS00790	COG1201	RNA secondary structure unwinding
F1E05_RS00805	COG0493	'glutamate synthase
F1E05_RS00805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F1E05_RS00820	COG2204	response regulator
F1E05_RS00825	COG5000	phosphorelay sensor kinase activity
F1E05_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1E05_RS00845	COG0242	peptide deformylase activity
F1E05_RS00855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F1E05_RS00870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F1E05_RS00870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1E05_RS00870	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1E05_RS00870	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1E05_RS00895	COG4974	Belongs to the 'phage' integrase family
F1E05_RS00915	COG4128	Pfam Zonular occludens toxin
F1E05_RS01030	COG3550	peptidyl-serine autophosphorylation
F1E05_RS01055	COG0582	viral genome integration into host DNA
F1E05_RS01065	COG0577	efflux transmembrane transporter activity
F1E05_RS01065	COG1136	(ABC) transporter
F1E05_RS01070	COG0577	efflux transmembrane transporter activity
F1E05_RS01070	COG1136	(ABC) transporter
F1E05_RS01095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F1E05_RS01100	COG0045	succinate-CoA ligase (ADP-forming) activity
F1E05_RS01120	COG5002	protein histidine kinase activity
F1E05_RS01120	COG5001	Diguanylate cyclase
F1E05_RS01140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F1E05_RS01145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1E05_RS01150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F1E05_RS01195	COG2226	methyltransferase
F1E05_RS01200	COG0535	radical SAM domain protein
F1E05_RS01225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F1E05_RS01235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1E05_RS01290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1E05_RS01295	COG0723	plastoquinol--plastocyanin reductase activity
F1E05_RS01300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F1E05_RS01305	COG2857	Cytochrome c1
F1E05_RS01315	COG2969	positive regulation of protein catabolic process
F1E05_RS01320	COG2154	pterin-4-alpha-carbinolamine dehydratase
F1E05_RS01330	COG1229	Formylmethanofuran dehydrogenase subunit A
F1E05_RS01335	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
F1E05_RS01350	COG2183	response to ionizing radiation
F1E05_RS01385	COG3094	Invasion gene expression up-regulator, SirB
F1E05_RS01400	COG2346	COG2346, Truncated hemoglobins
F1E05_RS01405	COG1451	nucleotide metabolic process
F1E05_RS01430	COG1615	UPF0182 protein
F1E05_RS01440	COG2062	phosphohistidine phosphatase, SixA
F1E05_RS01450	COG0429	hydrolase of the alpha beta-hydrolase fold
F1E05_RS01510	COG0523	cobalamin synthesis protein
F1E05_RS01515	COG1469	GTP cyclohydrolase I activity
F1E05_RS01525	COG1229	Formylmethanofuran dehydrogenase subunit A
F1E05_RS01565	COG0840	transmembrane signaling receptor activity
F1E05_RS01570	COG0668	transmembrane transport
F1E05_RS01575	COG3437	response regulator, receiver
F1E05_RS01580	COG5002	protein histidine kinase activity
F1E05_RS01580	COG0784	Response regulator, receiver
F1E05_RS01580	COG2205	protein histidine kinase activity
F1E05_RS01585	COG2854	intermembrane phospholipid transfer
F1E05_RS01615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1E05_RS01655	COG0837	glucose binding
F1E05_RS01665	COG0717	Belongs to the dCTP deaminase family
F1E05_RS01675	COG0433	COG0433 Predicted ATPase
F1E05_RS01685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F1E05_RS01695	COG0751	glycine-tRNA ligase activity
F1E05_RS01730	COG2862	Uncharacterized protein family, UPF0114
F1E05_RS01740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F1E05_RS01750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1E05_RS01755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1E05_RS01765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F1E05_RS01770	COG1765	OsmC-like protein
F1E05_RS01800	COG0653	protein targeting
F1E05_RS01805	COG0058	SHG alpha-glucan phosphorylase activity
F1E05_RS01810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F1E05_RS01815	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F1E05_RS01820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1E05_RS01830	COG1652	LysM domain
F1E05_RS01835	COG0758	DNA mediated transformation
F1E05_RS01840	COG2922	Belongs to the Smg family
F1E05_RS01860	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1E05_RS01865	COG0740	serine-type endopeptidase activity
F1E05_RS01870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1E05_RS01875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F1E05_RS01880	COG0776	regulation of translation
F1E05_RS01895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1E05_RS01915	COG1294	oxidase, subunit
F1E05_RS01925	COG0795	lipopolysaccharide-transporting ATPase activity
F1E05_RS01930	COG3706	GGDEF domain
F1E05_RS01930	COG4251	negative regulation of phosphorylation
F1E05_RS01930	COG5001	Diguanylate cyclase
F1E05_RS01930	COG2203	Gaf domain
F1E05_RS01950	COG4206	TonB-dependent receptor
F1E05_RS01970	COG1404	Belongs to the peptidase S8 family
F1E05_RS01980	COG0515	serine threonine protein kinase
F1E05_RS01980	COG2815	serine threonine protein kinase
F1E05_RS02000	COG2116	formate transmembrane transporter activity
F1E05_RS02005	COG0577	efflux transmembrane transporter activity
F1E05_RS02005	COG1136	(ABC) transporter
F1E05_RS02025	COG2267	carboxylic ester hydrolase activity
F1E05_RS02030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1E05_RS02035	COG0741	lytic transglycosylase activity
F1E05_RS02035	COG1388	LysM domain
F1E05_RS02040	COG2226	methyltransferase
F1E05_RS02045	COG0328	RNA-DNA hybrid ribonuclease activity
F1E05_RS02055	COG2827	Endonuclease containing a URI domain
F1E05_RS02065	COG2890	protein-(glutamine-N5) methyltransferase activity
F1E05_RS02070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1E05_RS02075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1E05_RS02085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F1E05_RS02090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1E05_RS02100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1E05_RS02105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F1E05_RS02110	COG0193	aminoacyl-tRNA hydrolase activity
F1E05_RS02120	COG2003	Belongs to the UPF0758 family
F1E05_RS02125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F1E05_RS02130	COG0756	dUTP diphosphatase activity
F1E05_RS02140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1E05_RS02160	COG0728	peptidoglycan biosynthetic process
F1E05_RS02165	COG0268	Binds directly to 16S ribosomal RNA
F1E05_RS02175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F1E05_RS02180	COG3122	Protein conserved in bacteria
F1E05_RS02210	COG0501	Belongs to the peptidase M48B family
F1E05_RS02215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1E05_RS02225	COG0483	inositol monophosphate 1-phosphatase activity
F1E05_RS02230	COG0004	ammonium transporteR
F1E05_RS02240	COG0004	ammonium transporteR
F1E05_RS02245	COG0347	Belongs to the P(II) protein family
F1E05_RS02255	COG0174	glutamine synthetase
F1E05_RS02260	COG0583	DNA-binding transcription factor activity
F1E05_RS02295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F1E05_RS02320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1E05_RS02325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1E05_RS02350	COG0564	pseudouridine synthase activity
F1E05_RS02355	COG1530	ribonuclease E activity
F1E05_RS02360	COG1322	Protein conserved in bacteria
F1E05_RS02365	COG0795	lipopolysaccharide-transporting ATPase activity
F1E05_RS02370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F1E05_RS02395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1E05_RS02425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1E05_RS02435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1E05_RS02445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F1E05_RS02450	COG0081	regulation of translation
F1E05_RS02455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1E05_RS02460	COG0222	ribosome binding
F1E05_RS02465	COG0085	RNA polymerase activity
F1E05_RS02470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1E05_RS02480	COG0049	tRNA binding
F1E05_RS02485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1E05_RS02490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1E05_RS02495	COG0051	transcription antitermination factor activity, RNA binding
F1E05_RS02500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F1E05_RS02505	COG0088	Forms part of the polypeptide exit tunnel
F1E05_RS02510	COG0089	rRNA binding
F1E05_RS02515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1E05_RS02520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1E05_RS02525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F1E05_RS02530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1E05_RS02535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F1E05_RS02545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1E05_RS02550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F1E05_RS02555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1E05_RS02560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1E05_RS02565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1E05_RS02570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1E05_RS02575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1E05_RS02580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1E05_RS02585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1E05_RS02590	COG1841	ribosomal large subunit assembly
F1E05_RS02595	COG0200	Binds to the 23S rRNA
F1E05_RS02600	COG0201	protein transport
F1E05_RS02605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1E05_RS02610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1E05_RS02615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F1E05_RS02620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F1E05_RS02630	COG0203	ribosomal protein L17
F1E05_RS02640	COG2204	response regulator
F1E05_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1E05_RS02645	COG3453	Protein conserved in bacteria
F1E05_RS02650	COG0730	response to heat
F1E05_RS02660	COG2132	Multicopper oxidase
F1E05_RS02685	COG1294	oxidase, subunit
F1E05_RS02705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F1E05_RS02710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F1E05_RS02715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1E05_RS02720	COG2755	lipolytic protein G-D-S-L family
F1E05_RS02720	COG1083	cytidylyl-transferase
F1E05_RS02725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F1E05_RS02740	COG4137	Cytochrome C assembly protein
F1E05_RS02745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1E05_RS02750	COG0228	four-way junction DNA binding
F1E05_RS02755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F1E05_RS02760	COG0336	Belongs to the RNA methyltransferase TrmD family
F1E05_RS02765	COG0335	large ribosomal subunit rRNA binding
F1E05_RS02770	COG4974	Belongs to the 'phage' integrase family
F1E05_RS02775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1E05_RS02785	COG0494	nUDIX hydrolase
F1E05_RS02790	COG1858	cytochrome C peroxidase
F1E05_RS02830	COG3344	reverse transcriptase
F1E05_RS02865	COG0582	viral genome integration into host DNA
F1E05_RS02940	COG0776	regulation of translation
F1E05_RS02945	COG0072	phenylalanine-tRNA ligase activity
F1E05_RS02945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1E05_RS02950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1E05_RS02955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1E05_RS02960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F1E05_RS02965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F1E05_RS02970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1E05_RS02995	COG3079	Belongs to the UPF0149 family
F1E05_RS03000	COG0006	proline dipeptidase activity
F1E05_RS03005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1E05_RS03015	COG0742	ribosomal rna small subunit methyltransferase
F1E05_RS03035	COG0719	Fe-S assembly protein
F1E05_RS03040	COG0396	ATPase activity
F1E05_RS03045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1E05_RS03070	COG0719	Fe-S assembly protein
F1E05_RS03075	COG1959	2 iron, 2 sulfur cluster binding
F1E05_RS03105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1E05_RS03115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1E05_RS03120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1E05_RS03125	COG0189	ligase activity
F1E05_RS03135	COG1678	Uncharacterized ACR, COG1678
F1E05_RS03140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F1E05_RS03145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F1E05_RS03150	COG0540	Belongs to the ATCase OTCase family
F1E05_RS03165	COG0714	Associated with various cellular activities
F1E05_RS03190	COG0281	malic enzyme
F1E05_RS03210	COG2358	TRAP transporter, solute receptor (TAXI family
F1E05_RS03240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1E05_RS03245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1E05_RS03260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1E05_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS03300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1E05_RS03330	COG0330	HflC and HflK could
F1E05_RS03345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F1E05_RS03350	COG0473	3-isopropylmalate dehydrogenase activity
F1E05_RS03360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1E05_RS03365	COG0563	adenylate kinase activity
F1E05_RS03370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1E05_RS03370	COG2205	protein histidine kinase activity
F1E05_RS03385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F1E05_RS03395	COG2010	Cytochrome c
F1E05_RS03430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1E05_RS03430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1E05_RS03480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1E05_RS03505	COG0339	signal peptide processing
F1E05_RS03525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1E05_RS03540	COG2854	intermembrane phospholipid transfer
F1E05_RS03545	COG4106	trans-aconitate 2-methyltransferase activity
F1E05_RS03550	COG0500	methyltransferase
F1E05_RS03580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1E05_RS03585	COG0191	fructose-bisphosphate aldolase activity
F1E05_RS03590	COG1580	Controls the rotational direction of flagella during chemotaxis
F1E05_RS03615	COG1987	bacterial-type flagellum assembly
F1E05_RS03630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F1E05_RS03655	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F1E05_RS03660	COG2198	Histidine kinase
F1E05_RS03660	COG0643	Histidine kinase
F1E05_RS03660	COG0784	Response regulator, receiver
F1E05_RS03665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F1E05_RS03675	COG1192	Involved in chromosome partitioning
F1E05_RS03685	COG0835	chemotaxis
F1E05_RS03700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1E05_RS03710	COG2967	ApaG domain
F1E05_RS03715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F1E05_RS03740	COG1199	ATP-dependent helicase activity
F1E05_RS03835	COG0625	glutathione transferase activity
F1E05_RS03850	COG1487	ribonuclease activity
F1E05_RS03860	COG1598	PFAM Uncharacterised protein family UPF0150
F1E05_RS03875	COG1785	Belongs to the alkaline phosphatase family
F1E05_RS03890	COG0714	Associated with various cellular activities
F1E05_RS03905	COG0606	chelatase, subunit chli
F1E05_RS03940	COG0254	rRNA binding
F1E05_RS03945	COG2211	Major facilitator Superfamily
F1E05_RS03955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1E05_RS03970	COG0793	Belongs to the peptidase S41A family
F1E05_RS03975	COG4942	peptidase
F1E05_RS03980	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F1E05_RS03990	COG1970	mechanosensitive ion channel activity
F1E05_RS03995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1E05_RS04000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F1E05_RS04005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1E05_RS04015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F1E05_RS04020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1E05_RS04025	COG1127	ABC transporter
F1E05_RS04035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F1E05_RS04045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F1E05_RS04050	COG1137	ATPase activity
F1E05_RS04055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F1E05_RS04065	COG1660	Displays ATPase and GTPase activities
F1E05_RS04070	COG2239	Acts as a magnesium transporter
F1E05_RS04075	COG0850	regulation of cytokinetic process
F1E05_RS04080	COG2894	cell division
F1E05_RS04085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F1E05_RS04140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F1E05_RS04145	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1E05_RS04160	COG0129	dihydroxy-acid dehydratase activity
F1E05_RS04170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1E05_RS04175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1E05_RS04180	COG2989	Protein conserved in bacteria
F1E05_RS04185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F1E05_RS04190	COG0067	glutamate synthase
F1E05_RS04190	COG0069	glutamate synthase activity
F1E05_RS04190	COG0070	glutamate synthase
F1E05_RS04195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1E05_RS04200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F1E05_RS04205	COG0024	Methionine aminopeptidase
F1E05_RS04210	COG0052	Belongs to the universal ribosomal protein uS2 family
F1E05_RS04215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1E05_RS04220	COG0528	UMP kinase activity
F1E05_RS04225	COG0233	cytoplasmic translational termination
F1E05_RS04230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1E05_RS04235	COG0575	Belongs to the CDS family
F1E05_RS04240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F1E05_RS04250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F1E05_RS04260	COG2202	Pas domain
F1E05_RS04260	COG1366	Belongs to the anti-sigma-factor antagonist family
F1E05_RS04270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1E05_RS04280	COG1090	epimerase
F1E05_RS04290	COG0415	Belongs to the DNA photolyase family
F1E05_RS04295	COG3272	Protein of unknown function (DUF1722)
F1E05_RS04320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1E05_RS04375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1E05_RS04395	COG3093	addiction module antidote protein HigA
F1E05_RS04455	COG1639	'signal transduction protein
F1E05_RS04510	COG3045	CreA protein
F1E05_RS04520	COG0564	pseudouridine synthase activity
F1E05_RS04535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1E05_RS04540	COG3383	formate dehydrogenase (NAD+) activity
F1E05_RS04545	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
F1E05_RS04550	COG3259	Nickel-dependent hydrogenase
F1E05_RS04575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F1E05_RS04580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F1E05_RS04595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1E05_RS04605	COG0217	transcriptional regulatory protein
F1E05_RS04610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F1E05_RS04615	COG0632	four-way junction helicase activity
F1E05_RS04620	COG2255	four-way junction helicase activity
F1E05_RS04625	COG0824	Thioesterase
F1E05_RS04645	COG0823	Involved in the tonB-independent uptake of proteins
F1E05_RS04650	COG2885	chlorophyll binding
F1E05_RS04655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
F1E05_RS04660	COG0602	queuosine metabolic process
F1E05_RS04665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F1E05_RS04680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1E05_RS04685	COG1702	phosphate starvation-inducible protein PhoH
F1E05_RS04690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1E05_RS04695	COG4535	Mg2 and Co2 transporter CorC
F1E05_RS04710	COG0633	Ferredoxin
F1E05_RS04715	COG0426	domain, Protein
F1E05_RS04755	COG3706	GGDEF domain
F1E05_RS04780	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F1E05_RS04820	COG1566	PFAM secretion protein HlyD family protein
F1E05_RS04840	COG0583	DNA-binding transcription factor activity
F1E05_RS04880	COG0439	Biotin carboxylase
F1E05_RS04895	COG1116	anion transmembrane transporter activity
F1E05_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS04930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1E05_RS04935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F1E05_RS04940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F1E05_RS04945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1E05_RS04950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F1E05_RS04955	COG1610	YqeY-like protein
F1E05_RS04960	COG0358	DNA primase activity
F1E05_RS04975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1E05_RS04980	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F1E05_RS05060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F1E05_RS05080	COG0535	radical SAM domain protein
F1E05_RS05100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F1E05_RS05110	COG0167	dihydroorotate dehydrogenase activity
F1E05_RS05125	COG1012	belongs to the aldehyde dehydrogenase family
F1E05_RS05145	COG1943	Transposase
F1E05_RS05175	COG1538	Outer membrane efflux protein
F1E05_RS05195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1E05_RS05200	COG1024	Enoyl-CoA hydratase
F1E05_RS05200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1E05_RS05205	COG4977	sequence-specific DNA binding
F1E05_RS05210	COG0641	radical SAM
F1E05_RS05220	COG4249	Peptidase C14 caspase catalytic subunit p20
F1E05_RS05220	COG2319	Wd-40 repeat
F1E05_RS05225	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F1E05_RS05230	COG5002	protein histidine kinase activity
F1E05_RS05230	COG2205	protein histidine kinase activity
F1E05_RS05230	COG0784	Response regulator, receiver
F1E05_RS05240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F1E05_RS05255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F1E05_RS05265	COG2264	protein methyltransferase activity
F1E05_RS05270	COG0439	Biotin carboxylase
F1E05_RS05275	COG0511	ligase activity, forming carbon-carbon bonds
F1E05_RS05280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F1E05_RS05285	COG0297	glycogen (starch) synthase activity
F1E05_RS05310	COG1490	D-aminoacyl-tRNA deacylase activity
F1E05_RS05325	COG1047	Peptidyl-prolyl cis-trans
F1E05_RS05375	COG0582	viral genome integration into host DNA
F1E05_RS05420	COG2003	Belongs to the UPF0758 family
F1E05_RS05440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F1E05_RS05445	COG0107	imidazoleglycerol-phosphate synthase activity
F1E05_RS05450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1E05_RS05455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1E05_RS05460	COG0131	Imidazoleglycerol-phosphate dehydratase
F1E05_RS05465	COG0308	aminopeptidase N
F1E05_RS05475	COG2363	Small membrane protein
F1E05_RS05480	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1E05_RS05485	COG0617	tRNA 3'-terminal CCA addition
F1E05_RS05495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F1E05_RS05500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F1E05_RS05505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1E05_RS05510	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
F1E05_RS05515	COG4206	TonB-dependent receptor
F1E05_RS05525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F1E05_RS05535	COG0628	permease
F1E05_RS05550	COG0730	response to heat
F1E05_RS05555	COG0617	tRNA 3'-terminal CCA addition
F1E05_RS05565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F1E05_RS05575	COG0312	modulator of DNA gyrase
F1E05_RS05580	COG0312	modulator of DNA gyrase
F1E05_RS05595	COG5002	protein histidine kinase activity
F1E05_RS05595	COG5001	Diguanylate cyclase
F1E05_RS05625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F1E05_RS05635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F1E05_RS05640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1E05_RS05650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1E05_RS05665	COG3100	YcgL domain-containing protein
F1E05_RS05685	COG0519	Catalyzes the synthesis of GMP from XMP
F1E05_RS05685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1E05_RS05760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1E05_RS05765	COG2226	methyltransferase
F1E05_RS05785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1E05_RS05790	COG0798	PFAM Bile acid sodium symporter
F1E05_RS05800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1E05_RS05825	COG1420	regulation of RNA biosynthetic process
F1E05_RS05830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1E05_RS05835	COG0443	Heat shock 70 kDa protein
F1E05_RS05840	COG0484	heat shock protein binding
F1E05_RS05845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1E05_RS05850	COG0505	Belongs to the CarA family
F1E05_RS05855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F1E05_RS05860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1E05_RS05870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F1E05_RS05880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1E05_RS05885	COG0149	triose-phosphate isomerase activity
F1E05_RS05900	COG0582	viral genome integration into host DNA
F1E05_RS05905	COG1192	Involved in chromosome partitioning
F1E05_RS05975	COG1011	Hydrolase
F1E05_RS06030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F1E05_RS06035	COG2824	Alkylphosphonate utilization operon protein PhnA
F1E05_RS06040	COG0500	methyltransferase
F1E05_RS06050	COG0557	exoribonuclease II activity
F1E05_RS06080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1E05_RS06085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F1E05_RS06090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F1E05_RS06095	COG0826	peptidase U32
F1E05_RS06110	COG0830	nickel cation binding
F1E05_RS06115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F1E05_RS06140	COG0745	RESPONSE REGULATOR receiver
F1E05_RS06145	COG1760	l-serine dehydratase
F1E05_RS06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS06205	COG3158	transport of potassium into the cell
F1E05_RS06240	COG5001	Diguanylate cyclase
F1E05_RS06240	COG5002	protein histidine kinase activity
F1E05_RS06240	COG3447	MASE1 domain protein
F1E05_RS06280	COG4964	Belongs to the GSP D family
F1E05_RS06320	COG2226	methyltransferase
F1E05_RS06325	COG2217	Heavy metal translocating P-type atpase
F1E05_RS06355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F1E05_RS06365	COG0791	NLP P60 protein
F1E05_RS06375	COG0134	indole-3-glycerol-phosphate synthase activity
F1E05_RS06390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1E05_RS06400	COG0432	Pfam Uncharacterised protein family UPF0047
F1E05_RS06420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1E05_RS06425	COG0581	inorganic phosphate transmembrane transporter activity
F1E05_RS06445	COG0252	asparaginase activity
F1E05_RS06480	COG0640	Transcriptional regulator
F1E05_RS06490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F1E05_RS06495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1E05_RS06515	COG2244	polysaccharide biosynthetic process
F1E05_RS06525	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS06595	COG0584	glycerophosphoryl diester phosphodiesterase
F1E05_RS06600	COG2205	protein histidine kinase activity
F1E05_RS06600	COG0784	Response regulator, receiver
F1E05_RS06605	COG0126	phosphoglycerate kinase activity
F1E05_RS06615	COG5001	Diguanylate cyclase
F1E05_RS06630	COG0189	ligase activity
F1E05_RS06635	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F1E05_RS06640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F1E05_RS06645	COG0235	Class ii aldolase
F1E05_RS06665	COG3350	monooxygenase activity
F1E05_RS06690	COG0543	2 iron, 2 sulfur cluster binding
F1E05_RS06690	COG0633	Ferredoxin
F1E05_RS06700	COG0459	protein refolding
F1E05_RS06705	COG3284	Transcriptional regulator
F1E05_RS06710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1E05_RS06730	COG2204	response regulator
F1E05_RS06735	COG3852	Histidine kinase
F1E05_RS06750	COG2815	serine threonine protein kinase
F1E05_RS06750	COG0515	serine threonine protein kinase
F1E05_RS06755	COG2223	nitrite transmembrane transporter activity
F1E05_RS06765	COG1324	tolerance protein
F1E05_RS06770	COG4232	protein-disulfide reductase activity
F1E05_RS06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1E05_RS06805	COG1686	Belongs to the peptidase S11 family
F1E05_RS06840	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
F1E05_RS06850	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F1E05_RS06880	COG1797	cobyrinic acid a,c-diamide synthase activity
F1E05_RS06920	COG1518	maintenance of DNA repeat elements
F1E05_RS06945	COG4453	Protein conserved in bacteria
F1E05_RS06980	COG1091	dTDP-4-dehydrorhamnose reductase activity
F1E05_RS07000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1E05_RS07015	COG0673	inositol 2-dehydrogenase activity
F1E05_RS07045	COG0408	coproporphyrinogen oxidase activity
F1E05_RS07055	COG1595	DNA-templated transcription, initiation
F1E05_RS07065	COG1404	Belongs to the peptidase S8 family
F1E05_RS07115	COG0004	ammonium transporteR
F1E05_RS07130	COG2831	hemolysin activation secretion protein
F1E05_RS07140	COG0811	peptide transport
F1E05_RS07195	COG2814	Major facilitator Superfamily
F1E05_RS07205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F1E05_RS07210	COG0071	Belongs to the small heat shock protein (HSP20) family
F1E05_RS07230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1E05_RS07235	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F1E05_RS07245	COG1640	4-alpha-glucanotransferase
F1E05_RS07255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F1E05_RS07260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F1E05_RS07265	COG0297	glycogen (starch) synthase activity
F1E05_RS07275	COG1902	pentaerythritol trinitrate reductase activity
F1E05_RS07280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F1E05_RS07290	COG2204	response regulator
F1E05_RS07330	COG0714	Associated with various cellular activities
F1E05_RS07340	COG2010	Cytochrome c
F1E05_RS07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1E05_RS07350	COG4993	Dehydrogenase
F1E05_RS07355	COG2197	response regulator
F1E05_RS07375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F1E05_RS07390	COG1459	type II secretion system
F1E05_RS07400	COG4970	Tfp pilus assembly protein FimT
F1E05_RS07405	COG2165	general secretion pathway protein
F1E05_RS07415	COG3156	type II secretion system protein K
F1E05_RS07420	COG3166	PFAM Fimbrial assembly family protein
F1E05_RS07435	COG1450	Type ii and iii secretion system protein
F1E05_RS07455	COG1518	maintenance of DNA repeat elements
F1E05_RS07460	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F1E05_RS07480	COG4115	mRNA cleavage
F1E05_RS07485	COG2161	toxin-antitoxin pair type II binding
F1E05_RS07505	COG1337	RAMP superfamily
F1E05_RS07515	COG1353	crispr-associated protein
F1E05_RS07550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F1E05_RS07555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F1E05_RS07560	COG4208	sulfate ABC transporter
F1E05_RS07570	COG0583	DNA-binding transcription factor activity
F1E05_RS07590	COG1643	Atp-dependent helicase
F1E05_RS07605	COG1067	ATP-dependent peptidase activity
F1E05_RS07610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1E05_RS07610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1E05_RS07620	COG0445	tRNA wobble uridine modification
F1E05_RS07625	COG0357	Ribosomal RNA small subunit methyltransferase G
F1E05_RS07630	COG1192	Involved in chromosome partitioning
F1E05_RS07635	COG1475	DNA binding
F1E05_RS07645	COG0356	it plays a direct role in the translocation of protons across the membrane
F1E05_RS07655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1E05_RS07660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1E05_RS07665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1E05_RS07670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1E05_RS07680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F1E05_RS07685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F1E05_RS07690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1E05_RS07715	COG3012	SEC-C Motif Domain Protein
F1E05_RS07745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F1E05_RS07750	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F1E05_RS07755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F1E05_RS07790	COG1278	Cold shock
F1E05_RS07795	COG2205	protein histidine kinase activity
F1E05_RS07800	COG0745	RESPONSE REGULATOR receiver
F1E05_RS07805	COG2095	MarC family integral membrane protein
F1E05_RS07825	COG0741	lytic transglycosylase activity
F1E05_RS07835	COG0484	heat shock protein binding
F1E05_RS07845	COG0443	Heat shock 70 kDa protein
F1E05_RS07865	COG0456	acetyltransferase
F1E05_RS07925	COG2271	Major facilitator Superfamily
F1E05_RS07935	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS07980	COG1214	PFAM Peptidase M22, glycoprotease
F1E05_RS07985	COG0009	L-threonylcarbamoyladenylate synthase
F1E05_RS07990	COG1994	Peptidase M50
F1E05_RS08000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1E05_RS08015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1E05_RS08020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1E05_RS08020	COG3153	acetyltransferase
F1E05_RS08050	COG2204	response regulator
F1E05_RS08085	COG0489	protein tyrosine kinase activity
F1E05_RS08120	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS08125	COG0367	asparagine synthase
F1E05_RS08130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F1E05_RS08135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F1E05_RS08140	COG3604	Transcriptional regulator
F1E05_RS08155	COG0784	Response regulator, receiver
F1E05_RS08155	COG2198	Histidine kinase
F1E05_RS08155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1E05_RS08155	COG2205	protein histidine kinase activity
F1E05_RS08180	COG0559	Belongs to the binding-protein-dependent transport system permease family
F1E05_RS08200	COG1172	Belongs to the binding-protein-dependent transport system permease family
F1E05_RS08215	COG0829	nickel cation binding
F1E05_RS08225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F1E05_RS08230	COG3383	formate dehydrogenase (NAD+) activity
F1E05_RS08250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1E05_RS08260	COG0459	protein refolding
F1E05_RS08275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1E05_RS08280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F1E05_RS08290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F1E05_RS08310	COG1587	Uroporphyrinogen-III synthase
F1E05_RS08315	COG0181	hydroxymethylbilane synthase activity
F1E05_RS08320	COG0742	ribosomal rna small subunit methyltransferase
F1E05_RS08325	COG0612	Peptidase, M16
F1E05_RS08330	COG0612	Peptidase, M16
F1E05_RS08335	COG0109	protoheme IX farnesyltransferase activity
F1E05_RS08340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1E05_RS08365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1E05_RS08385	COG0045	succinate-CoA ligase (ADP-forming) activity
F1E05_RS08390	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F1E05_RS08395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1E05_RS08405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F1E05_RS08410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F1E05_RS08420	COG2226	methyltransferase
F1E05_RS08430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F1E05_RS08460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F1E05_RS08470	COG1677	Flagellar hook-basal body complex protein FliE
F1E05_RS08490	COG4536	flavin adenine dinucleotide binding
F1E05_RS08495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1E05_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS08510	COG2151	metal-sulfur cluster biosynthetic enzyme
F1E05_RS08520	COG0835	chemotaxis
F1E05_RS08520	COG0784	Response regulator, receiver
F1E05_RS08675	COG1136	(ABC) transporter
F1E05_RS08705	COG2319	Wd-40 repeat
F1E05_RS08705	COG4249	Peptidase C14 caspase catalytic subunit p20
F1E05_RS08715	COG4249	Peptidase C14 caspase catalytic subunit p20
F1E05_RS08715	COG2319	Wd-40 repeat
F1E05_RS08755	COG2223	nitrite transmembrane transporter activity
F1E05_RS08770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F1E05_RS08775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F1E05_RS08785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1E05_RS08790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1E05_RS08790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1E05_RS08800	COG0356	it plays a direct role in the translocation of protons across the membrane
F1E05_RS08815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1E05_RS08845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1E05_RS08905	COG4716	Myosin-crossreactive antigen
F1E05_RS08920	COG3459	Glycosyltransferase 36 associated
F1E05_RS08995	COG1657	PFAM Prenyltransferase squalene oxidase
F1E05_RS09020	COG1858	cytochrome C peroxidase
F1E05_RS09035	COG1943	Transposase
F1E05_RS09075	COG0737	Belongs to the 5'-nucleotidase family
F1E05_RS09075	COG4085	toxin activity
F1E05_RS09075	COG1525	nuclease
F1E05_RS09090	COG0840	transmembrane signaling receptor activity
F1E05_RS09095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1E05_RS09100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F1E05_RS09105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F1E05_RS09110	COG0492	ferredoxin-NADP+ reductase activity
F1E05_RS09115	COG1674	ftsk spoiiie
F1E05_RS09145	COG1278	Cold shock
F1E05_RS09150	COG0586	Pfam SNARE associated Golgi protein
F1E05_RS09155	COG0628	permease
F1E05_RS09175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1E05_RS09180	COG2915	High frequency lysogenization protein hflD homolog
F1E05_RS09185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F1E05_RS09195	COG2608	mercury ion transmembrane transporter activity
F1E05_RS09195	COG2217	Heavy metal translocating P-type atpase
F1E05_RS09200	COG0316	Belongs to the HesB IscA family
F1E05_RS09205	COG2201	protein-glutamate methylesterase activity
F1E05_RS09210	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F1E05_RS09225	COG0840	transmembrane signaling receptor activity
F1E05_RS09240	COG0643	Histidine kinase
F1E05_RS09240	COG2198	Histidine kinase
F1E05_RS09250	COG2201	protein-glutamate methylesterase activity
F1E05_RS09255	COG0840	transmembrane signaling receptor activity
F1E05_RS09255	COG3290	protein histidine kinase activity
F1E05_RS09260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F1E05_RS09265	COG2193	ferroxidase activity
F1E05_RS09270	COG0708	Exodeoxyribonuclease III
F1E05_RS09280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F1E05_RS09280	COG3008	intermembrane lipid transfer
F1E05_RS09285	COG1127	ABC transporter
F1E05_RS09290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1E05_RS09315	COG0123	including yeast histone deacetylase and acetoin utilization protein
F1E05_RS09330	COG0574	Belongs to the PEP-utilizing enzyme family
F1E05_RS09330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1E05_RS09335	COG3706	GGDEF domain
F1E05_RS09340	COG0735	belongs to the Fur family
F1E05_RS09345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1E05_RS09350	COG0351	phosphomethylpyrimidine kinase
F1E05_RS09355	COG0352	thiamine-phosphate diphosphorylase activity
F1E05_RS09395	COG2917	probably involved in intracellular septation
F1E05_RS09400	COG2350	Protein conserved in bacteria
F1E05_RS09410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1E05_RS09435	COG0745	RESPONSE REGULATOR receiver
F1E05_RS09445	COG1891	lyase activity
F1E05_RS09460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1E05_RS09470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1E05_RS09475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1E05_RS09485	COG1216	Glycosyl transferase, family 2
F1E05_RS09505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1E05_RS09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS09560	COG0523	cobalamin synthesis protein
F1E05_RS09565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1E05_RS09585	COG0842	Transport permease protein
F1E05_RS09590	COG1131	(ABC) transporter
F1E05_RS09595	COG0248	Ppx GppA phosphatase
F1E05_RS09610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1E05_RS09635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1E05_RS09695	COG0165	Argininosuccinate lyase
F1E05_RS09705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1E05_RS09715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1E05_RS09740	COG3437	response regulator, receiver
F1E05_RS09780	COG0840	transmembrane signaling receptor activity
F1E05_RS09795	COG4771	TonB-dependent receptor
F1E05_RS09800	COG4771	TonB-dependent receptor
F1E05_RS09815	COG2205	protein histidine kinase activity
F1E05_RS09815	COG4999	Histidine kinase
F1E05_RS09815	COG3437	response regulator, receiver
F1E05_RS09815	COG3850	Histidine kinase
F1E05_RS09820	COG2198	Histidine kinase
F1E05_RS09820	COG0784	Response regulator, receiver
F1E05_RS09820	COG2205	protein histidine kinase activity
F1E05_RS09835	COG0436	Aminotransferase
F1E05_RS09845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1E05_RS09855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F1E05_RS09870	COG1763	Mo-molybdopterin cofactor biosynthetic process
F1E05_RS09885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F1E05_RS09900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1E05_RS09910	COG0101	tRNA pseudouridine synthase activity
F1E05_RS09915	COG0436	Aminotransferase
F1E05_RS09920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1E05_RS09925	COG2715	membrane protein required for spore maturation
F1E05_RS10015	COG1222	aaa ATPase
F1E05_RS10045	COG0482	sulfurtransferase activity
F1E05_RS10055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F1E05_RS10060	COG0542	response to heat
F1E05_RS10065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1E05_RS10070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F1E05_RS10075	COG2005	Transcriptional regulator
F1E05_RS10075	COG3585	molybdate ion transport
F1E05_RS10085	COG0583	DNA-binding transcription factor activity
F1E05_RS10095	COG1752	Esterase of the alpha-beta hydrolase superfamily
F1E05_RS10115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1E05_RS10115	COG0456	acetyltransferase
F1E05_RS10130	COG0778	Nitroreductase
F1E05_RS10135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F1E05_RS10140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1E05_RS10145	COG0800	Aldolase
F1E05_RS10160	COG0363	glucosamine-6-phosphate deaminase activity
F1E05_RS10165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1E05_RS10170	COG2078	PFAM AMMECR1 domain protein
F1E05_RS10175	COG1355	regulation of microtubule-based process
F1E05_RS10185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F1E05_RS10190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1E05_RS10190	COG2205	protein histidine kinase activity
F1E05_RS10195	COG3437	response regulator, receiver
F1E05_RS10205	COG0569	domain protein
F1E05_RS10205	COG2985	domain, Protein
F1E05_RS10220	COG1024	Enoyl-CoA hydratase
F1E05_RS10220	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1E05_RS10225	COG0183	Belongs to the thiolase family
F1E05_RS10235	COG0583	DNA-binding transcription factor activity
F1E05_RS10240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F1E05_RS10280	COG1570	exodeoxyribonuclease VII activity
F1E05_RS10285	COG5002	protein histidine kinase activity
F1E05_RS10285	COG5001	Diguanylate cyclase
F1E05_RS10290	COG3028	Belongs to the UPF0307 family
F1E05_RS10295	COG3829	transcription factor binding
F1E05_RS10295	COG3290	protein histidine kinase activity
F1E05_RS10300	COG2119	membrane
F1E05_RS10310	COG0484	heat shock protein binding
F1E05_RS10320	COG0714	Associated with various cellular activities
F1E05_RS10330	COG0437	4 iron, 4 sulfur cluster binding
F1E05_RS10335	COG0243	molybdopterin cofactor binding
F1E05_RS10340	COG0384	phenazine biosynthesis protein PhzF
F1E05_RS10345	COG2146	nitrite reductase [NAD(P)H] activity
F1E05_RS10350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1E05_RS10355	COG2223	nitrite transmembrane transporter activity
F1E05_RS10360	COG3707	response regulator
F1E05_RS10370	COG0735	belongs to the Fur family
F1E05_RS10380	COG1136	(ABC) transporter
F1E05_RS10390	COG0745	RESPONSE REGULATOR receiver
F1E05_RS10400	COG5002	protein histidine kinase activity
F1E05_RS10420	COG3108	Peptidase M15
F1E05_RS10430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F1E05_RS10435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1E05_RS10440	COG1301	dicarboxylic acid transport
F1E05_RS10445	COG3012	SEC-C Motif Domain Protein
F1E05_RS10450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1E05_RS10460	COG1858	cytochrome C peroxidase
F1E05_RS10465	COG2203	Gaf domain
F1E05_RS10465	COG5001	Diguanylate cyclase
F1E05_RS10465	COG4251	negative regulation of phosphorylation
F1E05_RS10465	COG3706	GGDEF domain
F1E05_RS10535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1E05_RS10565	COG1943	Transposase
F1E05_RS10585	COG0343	queuine tRNA-ribosyltransferase activity
F1E05_RS10635	COG1131	(ABC) transporter
F1E05_RS10640	COG0842	Transport permease protein
F1E05_RS10645	COG0842	Transport permease protein
F1E05_RS10665	COG0697	spore germination
F1E05_RS10670	COG0625	glutathione transferase activity
F1E05_RS10690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1E05_RS10710	COG0629	single-stranded DNA binding
F1E05_RS10715	COG2814	Major facilitator Superfamily
F1E05_RS10725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F1E05_RS10760	COG2925	Exonuclease
F1E05_RS10770	COG0574	Belongs to the PEP-utilizing enzyme family
F1E05_RS10770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1E05_RS10785	COG1671	Belongs to the UPF0178 family
F1E05_RS10850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F1E05_RS10855	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F1E05_RS10865	COG1509	lysine 2,3-aminomutase activity
F1E05_RS10870	COG2205	protein histidine kinase activity
F1E05_RS10870	COG0784	Response regulator, receiver
F1E05_RS10870	COG5002	protein histidine kinase activity
F1E05_RS10875	COG3706	GGDEF domain
F1E05_RS10875	COG5001	Diguanylate cyclase
F1E05_RS10875	COG4251	negative regulation of phosphorylation
F1E05_RS10875	COG2203	Gaf domain
F1E05_RS10885	COG2204	response regulator
F1E05_RS10890	COG0631	protein serine/threonine phosphatase activity
F1E05_RS10895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F1E05_RS10900	COG1381	Involved in DNA repair and RecF pathway recombination
F1E05_RS10905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F1E05_RS10910	COG0571	ribonuclease III activity
F1E05_RS10925	COG0481	GTPase activity
F1E05_RS10935	COG0598	Magnesium transport protein CorA
F1E05_RS10940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1E05_RS10945	COG3002	Belongs to the UPF0753 family
F1E05_RS10955	COG0659	secondary active sulfate transmembrane transporter activity
F1E05_RS10960	COG3852	Histidine kinase
F1E05_RS10965	COG2204	response regulator
F1E05_RS10985	COG2197	response regulator
F1E05_RS10995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1E05_RS11005	COG0037	tRNA processing
F1E05_RS11010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F1E05_RS11015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F1E05_RS11020	COG2835	tetraacyldisaccharide 4'-kinase activity
F1E05_RS11025	COG1663	tetraacyldisaccharide 4'-kinase activity
F1E05_RS11030	COG0848	biopolymer transport protein
F1E05_RS11035	COG0811	peptide transport
F1E05_RS11045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1E05_RS11090	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F1E05_RS11100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1E05_RS11100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1E05_RS11130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1E05_RS11135	COG0840	transmembrane signaling receptor activity
F1E05_RS11160	COG0577	efflux transmembrane transporter activity
F1E05_RS11160	COG1136	(ABC) transporter
F1E05_RS11165	COG1136	(ABC) transporter
F1E05_RS11165	COG0577	efflux transmembrane transporter activity
F1E05_RS11225	COG0494	nUDIX hydrolase
F1E05_RS11235	COG0501	Belongs to the peptidase M48B family
F1E05_RS11315	COG3568	Endonuclease Exonuclease Phosphatase
F1E05_RS11325	COG2198	Histidine kinase
F1E05_RS11325	COG0784	Response regulator, receiver
F1E05_RS11325	COG2205	protein histidine kinase activity
F1E05_RS11335	COG4191	Histidine kinase
F1E05_RS11340	COG3437	response regulator, receiver
F1E05_RS11345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1E05_RS11345	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1E05_RS11355	COG2871	sodium ion transport
F1E05_RS11360	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F1E05_RS11365	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F1E05_RS11370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F1E05_RS11390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F1E05_RS11410	COG0647	UMP catabolic process
F1E05_RS11415	COG2376	Dihydroxyacetone kinase
F1E05_RS11445	COG3344	reverse transcriptase
F1E05_RS11525	COG2902	Dehydrogenase
F1E05_RS11535	COG1366	Belongs to the anti-sigma-factor antagonist family
F1E05_RS11540	COG0804	urea catabolic process
F1E05_RS11545	COG0832	Belongs to the urease beta subunit family
F1E05_RS11550	COG0831	urea catabolic process
F1E05_RS11555	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
F1E05_RS11565	COG2161	toxin-antitoxin pair type II binding
F1E05_RS11570	COG4115	mRNA cleavage
F1E05_RS11580	COG1943	Transposase
F1E05_RS11590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F1E05_RS11595	COG1518	maintenance of DNA repeat elements
F1E05_RS11595	COG1468	defense response to virus
F1E05_RS11675	COG0495	leucyl-tRNA aminoacylation
F1E05_RS11680	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F1E05_RS11685	COG1466	dna polymerase III delta subunit
F1E05_RS11695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F1E05_RS11700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F1E05_RS11710	COG0613	PHP domain protein
F1E05_RS11715	COG1132	(ABC) transporter
F1E05_RS11730	COG0745	RESPONSE REGULATOR receiver
F1E05_RS11735	COG2205	protein histidine kinase activity
F1E05_RS11770	COG2003	Belongs to the UPF0758 family
F1E05_RS11800	COG4974	Belongs to the 'phage' integrase family
F1E05_RS11810	COG0706	membrane insertase activity
F1E05_RS11815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1E05_RS11820	COG0594	ribonuclease P activity
F1E05_RS11830	COG0784	Response regulator, receiver
F1E05_RS11830	COG4191	Histidine kinase
F1E05_RS11835	COG0840	transmembrane signaling receptor activity
F1E05_RS11835	COG3290	protein histidine kinase activity
F1E05_RS11845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F1E05_RS11885	COG3220	belongs to the UPF0276 family
F1E05_RS11905	COG2154	pterin-4-alpha-carbinolamine dehydratase
F1E05_RS11925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1E05_RS11935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1E05_RS11940	COG0746	molybdenum cofactor guanylyltransferase activity
F1E05_RS11975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1E05_RS12015	COG0436	Aminotransferase
F1E05_RS12025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1E05_RS12030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1E05_RS12060	COG2833	Protein of unknown function (DUF455)
F1E05_RS12070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1E05_RS12075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1E05_RS12080	COG1045	serine acetyltransferase
F1E05_RS12085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1E05_RS12105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F1E05_RS12115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1E05_RS12130	COG1049	propionate catabolic process, 2-methylcitrate cycle
F1E05_RS12150	COG0473	3-isopropylmalate dehydrogenase activity
F1E05_RS12155	COG1131	(ABC) transporter
F1E05_RS12165	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F1E05_RS12165	COG0662	Cupin 2, conserved barrel domain protein
F1E05_RS12205	COG1301	dicarboxylic acid transport
F1E05_RS12215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1E05_RS12220	COG0359	binds to the 23S rRNA
F1E05_RS12230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1E05_RS12235	COG0360	Binds together with S18 to 16S ribosomal RNA
F1E05_RS12265	COG0776	regulation of translation
F1E05_RS12275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1E05_RS12285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1E05_RS12295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F1E05_RS12310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1E05_RS12325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
F1E05_RS12330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F1E05_RS12350	COG0298	carbon dioxide binding
F1E05_RS12375	COG1773	rubredoxin
F1E05_RS12380	COG1773	rubredoxin
F1E05_RS12390	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F1E05_RS12480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1E05_RS12485	COG0708	Exodeoxyribonuclease III
F1E05_RS12495	COG4771	TonB-dependent receptor
F1E05_RS12505	COG4771	TonB-dependent receptor
F1E05_RS12515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1E05_RS12520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1E05_RS12525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1E05_RS12555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1E05_RS12560	COG3123	guanosine phosphorylase activity
F1E05_RS12580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1E05_RS12580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1E05_RS12585	COG3100	YcgL domain-containing protein
F1E05_RS12585	COG0561	phosphatase activity
F1E05_RS12590	COG0569	domain protein
F1E05_RS12610	COG3622	Belongs to the hyi family
F1E05_RS12615	COG2084	Dehydrogenase
F1E05_RS12635	COG1730	sister chromatid segregation
F1E05_RS12640	COG1858	cytochrome C peroxidase
F1E05_RS12645	COG3878	Protein conserved in bacteria
F1E05_RS12650	COG0028	Belongs to the TPP enzyme family
F1E05_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS12685	COG1132	(ABC) transporter
F1E05_RS12700	COG2217	Heavy metal translocating P-type atpase
F1E05_RS12730	COG0210	DNA helicase
F1E05_RS12735	COG0469	pyruvate kinase activity
F1E05_RS12740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1E05_RS12765	COG1116	anion transmembrane transporter activity
F1E05_RS12765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F1E05_RS12775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F1E05_RS12775	COG1116	anion transmembrane transporter activity
F1E05_RS12790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1E05_RS12795	COG0497	DNA recombination
F1E05_RS12815	COG0242	peptide deformylase activity
F1E05_RS12835	COG0529	Catalyzes the synthesis of activated sulfate
F1E05_RS12850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1E05_RS12890	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F1E05_RS12895	COG0556	nucleotide-excision repair
F1E05_RS12910	COG4691	Plasmid stability protein
F1E05_RS12915	COG1487	ribonuclease activity
F1E05_RS12930	COG1943	Transposase
F1E05_RS13025	COG2207	Transcriptional regulator
F1E05_RS13025	COG3708	Transcriptional regulator
F1E05_RS13075	COG1286	toxin biosynthetic process
F1E05_RS13085	COG0285	dihydrofolate synthase activity
F1E05_RS13090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F1E05_RS13095	COG0159	tryptophan synthase activity
F1E05_RS13100	COG0133	tryptophan synthase activity
F1E05_RS13105	COG0135	phosphoribosylanthranilate isomerase activity
F1E05_RS13115	COG1477	protein flavinylation
F1E05_RS13120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1E05_RS13135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1E05_RS13140	COG0733	neurotransmitter:sodium symporter activity
F1E05_RS13145	COG2867	negative regulation of translational initiation
F1E05_RS13150	COG2914	Belongs to the UPF0125 (RnfH) family
F1E05_RS13180	COG2133	pyrroloquinoline quinone binding
F1E05_RS13210	COG4302	ethanolamine ammonia-lyase activity
F1E05_RS13215	COG4303	Ethanolamine ammonia lyase large subunit
F1E05_RS13255	COG0463	Glycosyl transferase, family 2
F1E05_RS13255	COG1216	Glycosyl transferase, family 2
F1E05_RS13285	COG1269	ATP hydrolysis coupled proton transport
F1E05_RS13305	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
F1E05_RS13355	COG2376	Dihydroxyacetone kinase
F1E05_RS13390	COG1136	(ABC) transporter
F1E05_RS13390	COG0577	efflux transmembrane transporter activity
F1E05_RS13395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS13415	COG0859	PFAM glycosyl transferase family 9
F1E05_RS13430	COG0443	Heat shock 70 kDa protein
F1E05_RS13455	COG1215	transferase activity, transferring glycosyl groups
F1E05_RS13465	COG2244	polysaccharide biosynthetic process
F1E05_RS13485	COG0726	polysaccharide deacetylase
F1E05_RS13490	COG2983	Belongs to the UPF0260 family
F1E05_RS13495	COG2177	Part of the ABC transporter FtsEX involved in
F1E05_RS13500	COG2884	Cell division ATP-binding protein ftsE
F1E05_RS13505	COG0552	protein localization to endoplasmic reticulum
F1E05_RS13535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1E05_RS13540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1E05_RS13545	COG2703	oxygen carrier activity
F1E05_RS13550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F1E05_RS13555	COG2226	methyltransferase
F1E05_RS13560	COG2267	carboxylic ester hydrolase activity
F1E05_RS13565	COG0156	8-amino-7-oxononanoate synthase activity
F1E05_RS13570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1E05_RS13575	COG1040	competence protein
F1E05_RS13600	COG2226	methyltransferase
F1E05_RS13685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1E05_RS13695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1E05_RS13700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1E05_RS13725	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS13745	COG2205	protein histidine kinase activity
F1E05_RS13750	COG4566	intracellular signal transduction
F1E05_RS13795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F1E05_RS13800	COG0039	L-malate dehydrogenase activity
F1E05_RS13805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1E05_RS13815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1E05_RS13825	COG1573	uracil-dna glycosylase
F1E05_RS13830	COG0322	excinuclease ABC activity
F1E05_RS13835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1E05_RS13845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F1E05_RS13855	COG3001	Fructosamine kinase
F1E05_RS13860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1E05_RS13865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F1E05_RS13870	COG4260	virion core protein, lumpy skin disease virus
F1E05_RS13880	COG3161	chorismate lyase activity
F1E05_RS13940	COG0590	tRNA wobble adenosine to inosine editing
F1E05_RS13945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F1E05_RS13960	COG2900	Belongs to the SlyX family
F1E05_RS13985	COG1959	2 iron, 2 sulfur cluster binding
F1E05_RS14005	COG0702	epimerase
F1E05_RS14010	COG0702	epimerase
F1E05_RS14015	COG2197	response regulator
F1E05_RS14020	COG0442	prolyl-tRNA aminoacylation
F1E05_RS14025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F1E05_RS14040	COG2346	COG2346, Truncated hemoglobins
F1E05_RS14045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1E05_RS14050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F1E05_RS14055	COG0501	Belongs to the peptidase M48B family
F1E05_RS14060	COG1162	GTPase activity
F1E05_RS14065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1E05_RS14070	COG0321	lipoyl(octanoyl) transferase activity
F1E05_RS14075	COG2921	Belongs to the UPF0250 family
F1E05_RS14085	COG1686	Belongs to the peptidase S11 family
F1E05_RS14095	COG1519	Transferase
F1E05_RS14115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1E05_RS14135	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1E05_RS14140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1E05_RS14175	COG3706	GGDEF domain
F1E05_RS14200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F1E05_RS14200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F1E05_RS14205	COG0802	atpase or kinase
F1E05_RS14210	COG0860	N-Acetylmuramoyl-L-alanine amidase
F1E05_RS14215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F1E05_RS14220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F1E05_RS14225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F1E05_RS14240	COG0527	aspartate kinase activity
F1E05_RS14265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1E05_RS14305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F1E05_RS14310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F1E05_RS14315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1E05_RS14320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F1E05_RS14335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1E05_RS14335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1E05_RS14340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F1E05_RS14345	COG3264	Mechanosensitive ion channel
F1E05_RS14345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F1E05_RS14365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F1E05_RS14370	COG0617	tRNA 3'-terminal CCA addition
F1E05_RS14370	COG0517	IMP dehydrogenase activity
F1E05_RS14370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1E05_RS14400	COG0537	adenosine 5'-monophosphoramidase activity
F1E05_RS14410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1E05_RS14430	COG2205	protein histidine kinase activity
F1E05_RS14440	COG5002	protein histidine kinase activity
F1E05_RS14445	COG0745	RESPONSE REGULATOR receiver
F1E05_RS14450	COG0729	surface antigen
F1E05_RS14455	COG2911	Protein conserved in bacteria
F1E05_RS14470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F1E05_RS14480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F1E05_RS14505	COG1472	Belongs to the glycosyl hydrolase 3 family
F1E05_RS14510	COG2201	protein-glutamate methylesterase activity
F1E05_RS14550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS14570	COG1733	regulation of RNA biosynthetic process
F1E05_RS14575	COG1858	cytochrome C peroxidase
F1E05_RS14580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1E05_RS14605	COG0515	serine threonine protein kinase
F1E05_RS14605	COG2815	serine threonine protein kinase
F1E05_RS14610	COG0631	protein serine/threonine phosphatase activity
F1E05_RS14615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1E05_RS14630	COG0430	RNA-3'-phosphate cyclase activity
F1E05_RS14635	COG1690	Belongs to the RtcB family
F1E05_RS14645	COG4650	regulator
F1E05_RS14650	COG1074	ATP-dependent DNA helicase activity
F1E05_RS14655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1E05_RS14660	COG0741	lytic transglycosylase activity
F1E05_RS14670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F1E05_RS14675	COG1053	succinate dehydrogenase
F1E05_RS14680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F1E05_RS14690	COG5508	conserved small protein
F1E05_RS14695	COG0372	Belongs to the citrate synthase family
F1E05_RS14740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1E05_RS14745	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
F1E05_RS14760	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
F1E05_RS14855	COG5290	Psort location Cytoplasmic, score
F1E05_RS14860	COG0210	DNA helicase
F1E05_RS14885	COG3177	Filamentation induced by cAMP protein fic
F1E05_RS14930	COG2010	Cytochrome c
F1E05_RS14935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1E05_RS14945	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1E05_RS14950	COG2226	methyltransferase
F1E05_RS14955	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS14960	COG0859	PFAM glycosyl transferase family 9
F1E05_RS14995	COG1131	(ABC) transporter
F1E05_RS15000	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS15015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1E05_RS15055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1E05_RS15060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1E05_RS15065	COG3026	antisigma factor binding
F1E05_RS15090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1E05_RS15100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1E05_RS15105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1E05_RS15125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F1E05_RS15135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F1E05_RS15140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1E05_RS15155	COG0697	spore germination
F1E05_RS15160	COG2957	Belongs to the agmatine deiminase family
F1E05_RS15165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1E05_RS15170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F1E05_RS15170	COG0475	glutathione-regulated potassium exporter activity
F1E05_RS15190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F1E05_RS15210	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS15215	COG0297	glycogen (starch) synthase activity
F1E05_RS15230	COG1981	membrane
F1E05_RS15260	COG0840	transmembrane signaling receptor activity
F1E05_RS15290	COG0280	phosphate acetyltransferase
F1E05_RS15290	COG0857	belongs to the CobB CobQ family
F1E05_RS15300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F1E05_RS15320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F1E05_RS15325	COG0825	malonyl-CoA metabolic process
F1E05_RS15330	COG0037	tRNA processing
F1E05_RS15335	COG0504	CTP synthase activity
F1E05_RS15340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F1E05_RS15350	COG0148	phosphopyruvate hydratase activity
F1E05_RS15355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F1E05_RS15360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F1E05_RS15365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F1E05_RS15370	COG0585	pseudouridine synthase activity
F1E05_RS15380	COG0456	acetyltransferase
F1E05_RS15385	COG1573	uracil-dna glycosylase
F1E05_RS15390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1E05_RS15405	COG1185	polyribonucleotide nucleotidyltransferase activity
F1E05_RS15410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1E05_RS15415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1E05_RS15425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1E05_RS15430	COG0195	Participates in both transcription termination and antitermination
F1E05_RS15435	COG0779	Required for maturation of 30S ribosomal subunits
F1E05_RS15455	COG0488	(ABC) transporter
F1E05_RS15465	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS15470	COG1902	pentaerythritol trinitrate reductase activity
F1E05_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS15480	COG0583	DNA-binding transcription factor activity
F1E05_RS15485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1E05_RS15485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F1E05_RS15495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1E05_RS15500	COG0494	nUDIX hydrolase
F1E05_RS15510	COG0425	Belongs to the sulfur carrier protein TusA family
F1E05_RS15515	COG1648	precorrin-2 dehydrogenase activity
F1E05_RS15515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F1E05_RS15530	COG0137	argininosuccinate synthase activity
F1E05_RS15555	COG0138	bifunctional purine biosynthesis protein purh
F1E05_RS15560	COG1473	amidohydrolase
F1E05_RS15565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F1E05_RS15645	COG2944	sequence-specific DNA binding
F1E05_RS15670	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
F1E05_RS15680	COG3645	SOS response
F1E05_RS15700	COG0582	viral genome integration into host DNA
F1E05_RS15715	COG3657	addiction module killer protein
F1E05_RS15720	COG1966	Carbon starvation protein
F1E05_RS15730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F1E05_RS15735	COG0402	S-adenosylhomocysteine deaminase activity
F1E05_RS15755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1E05_RS15760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F1E05_RS15780	COG4783	chaperone-mediated protein folding
F1E05_RS15820	COG0463	Glycosyl transferase, family 2
F1E05_RS15820	COG1216	Glycosyl transferase, family 2
F1E05_RS15825	COG1454	alcohol dehydrogenase
F1E05_RS15830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F1E05_RS15860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1E05_RS15915	COG3178	'Phosphotransferase
F1E05_RS15920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F1E05_RS15925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1E05_RS15940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F1E05_RS15950	COG1472	Belongs to the glycosyl hydrolase 3 family
F1E05_RS15955	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F1E05_RS15960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F1E05_RS15985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1E05_RS15995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F1E05_RS16000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F1E05_RS16005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F1E05_RS16010	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F1E05_RS16015	COG0330	HflC and HflK could
F1E05_RS16020	COG0330	HflC and HflK could
F1E05_RS16025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F1E05_RS16030	COG1923	regulation of RNA biosynthetic process
F1E05_RS16035	COG0488	(ABC) transporter
F1E05_RS16045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1E05_RS16095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS16170	COG4615	Cyclic peptide transporter
F1E05_RS16190	COG4774	siderophore transport
F1E05_RS16230	COG1160	GTP binding
F1E05_RS16245	COG0124	histidyl-tRNA synthetase
F1E05_RS16255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1E05_RS16260	COG0105	UTP biosynthetic process
F1E05_RS16265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1E05_RS16270	COG1862	Preprotein translocase
F1E05_RS16285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F1E05_RS16295	COG1492	cobalamin metabolic process
F1E05_RS16300	COG0778	Nitroreductase
F1E05_RS16305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F1E05_RS16315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F1E05_RS16325	COG0589	response to stress
F1E05_RS16335	COG0488	(ABC) transporter
F1E05_RS16355	COG0513	Belongs to the DEAD box helicase family
F1E05_RS16365	COG1278	Cold shock
F1E05_RS16385	COG0515	serine threonine protein kinase
F1E05_RS16385	COG2815	serine threonine protein kinase
F1E05_RS16405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F1E05_RS16410	COG4181	ATPase activity
F1E05_RS16435	COG3300	MHYT domain
F1E05_RS16435	COG5001	Diguanylate cyclase
F1E05_RS16440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1E05_RS16450	COG4249	Peptidase C14 caspase catalytic subunit p20
F1E05_RS16450	COG2319	Wd-40 repeat
F1E05_RS16460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1E05_RS16495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1E05_RS16500	COG1960	acyl-CoA dehydrogenase activity
F1E05_RS16515	COG2086	electron transfer activity
F1E05_RS16520	COG4172	Belongs to the ABC transporter superfamily
F1E05_RS16525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1E05_RS16530	COG0601	transmembrane transport
F1E05_RS16540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F1E05_RS16545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1E05_RS16655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F1E05_RS16670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F1E05_RS16675	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1E05_RS16680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F1E05_RS16685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1E05_RS16690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1E05_RS16695	COG0772	Belongs to the SEDS family
F1E05_RS16700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1E05_RS16705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1E05_RS16710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F1E05_RS16715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1E05_RS16725	COG3116	cell division
F1E05_RS16730	COG0275	rRNA processing
F1E05_RS16735	COG2001	Belongs to the MraZ family
F1E05_RS16750	COG1132	(ABC) transporter
F1E05_RS16765	COG0420	3'-5' exonuclease activity
F1E05_RS16780	COG4251	negative regulation of phosphorylation
F1E05_RS16785	COG0784	Response regulator, receiver
F1E05_RS16795	COG3209	COG3209 Rhs family protein
F1E05_RS16855	COG2076	Multidrug Resistance protein
F1E05_RS16865	COG2135	peptidase activity
F1E05_RS16890	COG1138	Cytochrome C-type biogenesis protein
F1E05_RS16895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F1E05_RS16915	COG4133	protoheme IX ABC transporter activity
F1E05_RS16920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1E05_RS16925	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F1E05_RS16930	COG0792	nuclease activity
F1E05_RS16935	COG3107	peptidoglycan biosynthetic process
F1E05_RS16945	COG0517	IMP dehydrogenase activity
F1E05_RS16975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1E05_RS16980	COG1166	arginine decarboxylase activity
F1E05_RS16985	COG2084	Dehydrogenase
F1E05_RS17000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F1E05_RS17000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F1E05_RS17010	COG0033	Phosphoglucomutase
F1E05_RS17025	COG1376	ErfK ybiS ycfS ynhG family protein
F1E05_RS17030	COG2974	May be involved in recombination
F1E05_RS17065	COG2815	serine threonine protein kinase
F1E05_RS17065	COG0515	serine threonine protein kinase
F1E05_RS17070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1E05_RS17070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1E05_RS17075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1E05_RS17100	COG1690	Belongs to the RtcB family
F1E05_RS17110	COG0483	inositol monophosphate 1-phosphatase activity
F1E05_RS17115	COG1943	Transposase
F1E05_RS17125	COG3039	Transposase
F1E05_RS17145	COG0840	transmembrane signaling receptor activity
F1E05_RS17165	COG3273	potassium ion transport
F1E05_RS17165	COG0471	metal ion transport
F1E05_RS17185	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS17200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F1E05_RS17205	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F1E05_RS17205	COG4932	domain protein
F1E05_RS17205	COG3266	domain, Protein
F1E05_RS17220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS17225	COG1538	Outer membrane efflux protein
F1E05_RS17250	COG0514	ATP-dependent DNA helicase (RecQ)
F1E05_RS17255	COG2918	glutathione biosynthetic process
F1E05_RS17270	COG3956	TIGRFAM MazG family protein
F1E05_RS17275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1E05_RS17280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F1E05_RS17285	COG0509	glycine decarboxylation via glycine cleavage system
F1E05_RS17310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1E05_RS17315	COG0543	2 iron, 2 sulfur cluster binding
F1E05_RS17315	COG0493	'glutamate synthase
F1E05_RS17325	COG1278	Cold shock
F1E05_RS17330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1E05_RS17335	COG2920	part of a sulfur-relay system
F1E05_RS17350	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
F1E05_RS17355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F1E05_RS17395	COG0745	RESPONSE REGULATOR receiver
F1E05_RS17400	COG2198	Histidine kinase
F1E05_RS17400	COG0643	Histidine kinase
F1E05_RS17415	COG0835	chemotaxis
F1E05_RS17420	COG1192	Involved in chromosome partitioning
F1E05_RS17435	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F1E05_RS17445	COG0840	transmembrane signaling receptor activity
F1E05_RS17460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F1E05_RS17500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1E05_RS17510	COG2205	protein histidine kinase activity
F1E05_RS17510	COG2202	Pas domain
F1E05_RS17545	COG1943	Transposase
F1E05_RS17555	COG1543	Belongs to the glycosyl hydrolase 57 family
F1E05_RS17565	COG1132	(ABC) transporter
F1E05_RS17610	COG0302	gtp cyclohydrolase
F1E05_RS17615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F1E05_RS17620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1E05_RS17625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F1E05_RS17630	COG0741	lytic transglycosylase activity
F1E05_RS17630	COG0739	heme binding
F1E05_RS17630	COG1196	nuclear chromosome segregation
F1E05_RS17640	COG0424	maF-like protein
F1E05_RS17655	COG0416	fatty acid biosynthetic process
F1E05_RS17660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1E05_RS17665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F1E05_RS17675	COG3174	membrane
F1E05_RS17680	COG3300	MHYT domain
F1E05_RS17680	COG5001	Diguanylate cyclase
F1E05_RS17690	COG1194	a g-specific adenine glycosylase
F1E05_RS17695	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F1E05_RS17715	COG0175	sulfate reduction
F1E05_RS17720	COG0659	secondary active sulfate transmembrane transporter activity
F1E05_RS17725	COG0288	reversible hydration of carbon dioxide
F1E05_RS17740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1E05_RS17745	COG3002	Belongs to the UPF0753 family
F1E05_RS17750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1E05_RS17755	COG0514	ATP-dependent DNA helicase (RecQ)
F1E05_RS17800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1E05_RS17825	COG3436	PFAM IS66 Orf2 family protein
F1E05_RS17840	COG3344	reverse transcriptase
F1E05_RS17870	COG0714	Associated with various cellular activities
F1E05_RS17880	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F1E05_RS17895	COG2197	response regulator
F1E05_RS17900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1E05_RS17900	COG2205	protein histidine kinase activity
F1E05_RS17930	COG1032	radical SAM domain protein
F1E05_RS17950	COG0022	dehydrogenase e1 component
F1E05_RS17955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1E05_RS17960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1E05_RS17960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1E05_RS17965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F1E05_RS18000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F1E05_RS18010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1E05_RS18020	COG0418	dihydroorotase activity
F1E05_RS18025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F1E05_RS18030	COG0463	Glycosyl transferase, family 2
F1E05_RS18040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F1E05_RS18045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F1E05_RS18055	COG1538	Outer membrane efflux protein
F1E05_RS18060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1E05_RS18065	COG3851	Histidine kinase
F1E05_RS18105	COG3344	reverse transcriptase
F1E05_RS18205	COG2890	protein-(glutamine-N5) methyltransferase activity
F1E05_RS18220	COG0653	protein targeting
F1E05_RS18225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS18230	COG1538	Outer membrane efflux protein
F1E05_RS18235	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS18240	COG1216	Glycosyl transferase, family 2
F1E05_RS18240	COG0438	transferase activity, transferring glycosyl groups
F1E05_RS18265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1E05_RS18270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1E05_RS18275	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F1E05_RS18280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1E05_RS18285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1E05_RS18295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1E05_RS18300	COG1758	RNA polymerase activity
F1E05_RS18305	COG4783	chaperone-mediated protein folding
F1E05_RS18310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F1E05_RS18325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F1E05_RS18325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F1E05_RS18330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F1E05_RS18355	COG0330	HflC and HflK could
F1E05_RS18360	COG0330	HflC and HflK could
F1E05_RS18425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F1E05_RS18430	COG3411	Ferredoxin
F1E05_RS18455	COG0247	lactate metabolic process
F1E05_RS18485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1E05_RS18510	COG4657	Part of a membrane complex involved in electron transport
F1E05_RS18515	COG2878	Part of a membrane complex involved in electron transport
F1E05_RS18520	COG4656	Part of a membrane complex involved in electron transport
F1E05_RS18525	COG4658	electron transport chain
F1E05_RS18540	COG2914	Belongs to the UPF0125 (RnfH) family
F1E05_RS18550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1E05_RS18595	COG3723	Recombinational DNA repair protein, rece pathway
F1E05_RS18635	COG0582	viral genome integration into host DNA
F1E05_RS18655	COG3630	sodium ion export across plasma membrane
F1E05_RS18665	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F1E05_RS18670	COG1815	bacterial-type flagellum-dependent cell motility
F1E05_RS18675	COG1558	bacterial-type flagellum-dependent cell motility
F1E05_RS18680	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F1E05_RS18685	COG1749	Flagellar hook protein flgE
F1E05_RS18690	COG4787	bacterial-type flagellum-dependent cell motility
F1E05_RS18695	COG4786	Flagellar basal body rod
F1E05_RS18700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F1E05_RS18710	COG3951	Flagellar rod assembly protein muramidase FlgJ
F1E05_RS18710	COG1705	Flagellar rod assembly protein muramidase FlgJ
F1E05_RS18715	COG1256	bacterial-type flagellum assembly
F1E05_RS18715	COG4786	Flagellar basal body rod
F1E05_RS18720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F1E05_RS18725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F1E05_RS18740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F1E05_RS18745	COG0424	maF-like protein
F1E05_RS18750	COG1530	ribonuclease E activity
F1E05_RS18770	COG0315	cyclic pyranopterin monophosphate synthase activity
F1E05_RS18775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F1E05_RS18780	COG0314	molybdopterin synthase activity
F1E05_RS18785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1E05_RS18800	COG2137	regulation of response to DNA damage stimulus
F1E05_RS18805	COG1722	exodeoxyribonuclease VII activity
F1E05_RS18810	COG0142	geranyltranstransferase activity
F1E05_RS18815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1E05_RS18820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1E05_RS18825	COG2853	Lipoprotein
F1E05_RS18835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1E05_RS18845	COG1657	PFAM Prenyltransferase squalene oxidase
F1E05_RS18870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1E05_RS18875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1E05_RS18880	COG2813	Specifically methylates the guanine in position
F1E05_RS18885	COG0084	hydrolase, TatD family'
F1E05_RS18895	COG0470	DNA polymerase III
F1E05_RS18900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F1E05_RS18905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F1E05_RS18910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1E05_RS18915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1E05_RS18920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1E05_RS18935	COG0386	Belongs to the glutathione peroxidase family
F1E05_RS18990	COG0326	Molecular chaperone. Has ATPase activity
F1E05_RS19015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1E05_RS19020	COG1393	Belongs to the ArsC family
F1E05_RS19040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1E05_RS19045	COG0730	response to heat
F1E05_RS19050	COG1217	gtp-binding protein TYPA
F1E05_RS19065	COG0583	DNA-binding transcription factor activity
F1E05_RS19070	COG0140	phosphoribosyl-ATP diphosphatase activity
F1E05_RS19075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1E05_RS19080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1E05_RS19085	COG0805	protein transport
F1E05_RS19095	COG0018	arginyl-trna synthetase
F1E05_RS19120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1E05_RS19125	COG1183	phosphatidylcholine synthase activity
F1E05_RS19140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F1E05_RS19145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F1E05_RS19155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1E05_RS19160	COG4221	oxidoreductase activity
F1E05_RS19170	COG0196	riboflavin kinase activity
F1E05_RS19180	COG0489	protein tyrosine kinase activity
F1E05_RS19185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F1E05_RS19190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1E05_RS19195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1E05_RS19200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F1E05_RS19205	COG0142	geranyltranstransferase activity
F1E05_RS19215	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F1E05_RS19225	COG0419	ATPase involved in DNA repair
F1E05_RS19230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1E05_RS19245	COG0482	sulfurtransferase activity
F1E05_RS19255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1E05_RS19260	COG0494	nUDIX hydrolase
F1E05_RS19265	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F1E05_RS19270	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F1E05_RS19275	COG0237	dephospho-CoA kinase activity
F1E05_RS19280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F1E05_RS19295	COG0745	RESPONSE REGULATOR receiver
F1E05_RS19305	COG0525	valine-tRNA ligase activity
F1E05_RS19330	COG3391	amine dehydrogenase activity
F1E05_RS19345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F1E05_RS19350	COG1309	transcriptional regulator
F1E05_RS19380	COG4589	Belongs to the CDS family
F1E05_RS19405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1E05_RS19420	COG3404	Formiminotransferase-cyclodeaminase
F1E05_RS19425	COG0215	cysteine-tRNA ligase activity
F1E05_RS19435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1E05_RS19445	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1E05_RS19450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1E05_RS19465	COG5001	Diguanylate cyclase
F1E05_RS19465	COG5002	protein histidine kinase activity
F1E05_RS19475	COG1011	Hydrolase
F1E05_RS19495	COG4178	(ABC) transporter
F1E05_RS19510	COG0284	orotidine-5'-phosphate decarboxylase activity
F1E05_RS19515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1E05_RS19525	COG0154	amidase activity
F1E05_RS19530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1E05_RS19535	COG1077	Cell shape determining protein MreB Mrl
F1E05_RS19540	COG1792	Involved in formation and maintenance of cell shape
F1E05_RS19550	COG0768	penicillin binding
F1E05_RS19555	COG0772	Belongs to the SEDS family
F1E05_RS19560	COG2951	lytic endotransglycosylase activity
F1E05_RS19595	COG0535	radical SAM domain protein
F1E05_RS19605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F1E05_RS19645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F1E05_RS19655	COG2089	acid synthase
F1E05_RS19660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1E05_RS19665	COG0305	Participates in initiation and elongation during chromosome replication
F1E05_RS19670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F1E05_RS19685	COG1238	metal cluster binding
F1E05_RS19700	COG0166	Belongs to the GPI family
F1E05_RS19720	COG1278	Cold shock
F1E05_RS19725	COG0542	response to heat
F1E05_RS19730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1E05_RS19740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F1E05_RS19770	COG3344	reverse transcriptase
F1E05_RS19790	COG1959	2 iron, 2 sulfur cluster binding
F1E05_RS19800	COG2010	Cytochrome c
F1E05_RS19805	COG3256	nitric oxide reductase
F1E05_RS19815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F1E05_RS19820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F1E05_RS19825	COG0538	isocitrate dehydrogenase activity
F1E05_RS19845	COG2951	lytic endotransglycosylase activity
F1E05_RS19850	COG2171	N-acyltransferase activity
F1E05_RS19855	COG0436	Aminotransferase
F1E05_RS19860	COG0501	Belongs to the peptidase M48B family
F1E05_RS19865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1E05_RS19870	COG0604	alcohol dehydrogenase
F1E05_RS19870	COG1028	Short-chain dehydrogenase reductase Sdr
F1E05_RS19870	COG3321	synthase
F1E05_RS19885	COG0300	oxidoreductase activity
F1E05_RS19905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F1E05_RS19910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1E05_RS19925	COG0463	Glycosyl transferase, family 2
F1E05_RS19960	COG0367	asparagine synthase
F1E05_RS19975	COG1393	Belongs to the ArsC family
F1E05_RS19980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1E05_RS19990	COG0463	Glycosyl transferase, family 2
F1E05_RS19995	COG1215	transferase activity, transferring glycosyl groups
F1E05_RS20010	COG1132	(ABC) transporter
F1E05_RS20020	COG2091	lysine biosynthetic process via aminoadipic acid
F1E05_RS20025	COG0028	Belongs to the TPP enzyme family
F1E05_RS20030	COG0440	acetolactate synthase activity
F1E05_RS20035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1E05_RS20045	COG1739	Uncharacterized protein family UPF0029
F1E05_RS20075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1E05_RS20085	COG0519	Catalyzes the synthesis of GMP from XMP
F1E05_RS20090	COG0748	coenzyme F420 binding
F1E05_RS20115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity