locus-tag	class	description
IVG45_RS00110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IVG45_RS00130	COG2135	peptidase activity
IVG45_RS00135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IVG45_RS00140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IVG45_RS00160	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IVG45_RS00175	COG2226	methyltransferase
IVG45_RS00180	COG2217	Heavy metal translocating P-type atpase
IVG45_RS00190	COG0776	regulation of translation
IVG45_RS00195	COG0776	regulation of translation
IVG45_RS00200	COG0653	protein targeting
IVG45_RS00220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IVG45_RS00275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IVG45_RS00355	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IVG45_RS00390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IVG45_RS00390	COG1648	precorrin-2 dehydrogenase activity
IVG45_RS00415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IVG45_RS00420	COG4804	nuclease activity
IVG45_RS00435	COG2963	transposase activity
IVG45_RS00460	COG1278	Cold shock
IVG45_RS00515	COG3451	type IV secretory pathway VirB4
IVG45_RS00525	COG3838	Conjugal transfer protein Trbc
IVG45_RS00530	COG4962	Type ii secretion system protein e
IVG45_RS00550	COG0745	RESPONSE REGULATOR receiver
IVG45_RS00555	COG0443	Heat shock 70 kDa protein
IVG45_RS00575	COG0484	heat shock protein binding
IVG45_RS00580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IVG45_RS00590	COG0505	Belongs to the CarA family
IVG45_RS00595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IVG45_RS00600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IVG45_RS00620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IVG45_RS00625	COG0149	triose-phosphate isomerase activity
IVG45_RS00640	COG0582	viral genome integration into host DNA
IVG45_RS00695	COG0678	peroxiredoxin activity
IVG45_RS00705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IVG45_RS00715	COG3604	Transcriptional regulator
IVG45_RS00745	COG1269	ATP hydrolysis coupled proton transport
IVG45_RS00765	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IVG45_RS00770	COG2326	polyphosphate kinase activity
IVG45_RS00775	COG3064	Membrane
IVG45_RS00785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IVG45_RS00815	COG3604	Transcriptional regulator
IVG45_RS00850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IVG45_RS00850	COG3264	Mechanosensitive ion channel
IVG45_RS00860	COG3119	arylsulfatase activity
IVG45_RS00900	COG0628	permease
IVG45_RS00915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IVG45_RS00925	COG3437	response regulator, receiver
IVG45_RS00925	COG0784	Response regulator, receiver
IVG45_RS00940	COG0366	Alpha amylase catalytic
IVG45_RS00955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IVG45_RS00985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IVG45_RS01035	COG4191	Histidine kinase
IVG45_RS01075	COG0625	glutathione transferase activity
IVG45_RS01080	COG2703	oxygen carrier activity
IVG45_RS01090	COG4191	Histidine kinase
IVG45_RS01095	COG4566	intracellular signal transduction
IVG45_RS01140	COG1858	cytochrome C peroxidase
IVG45_RS01140	COG1858	cytochrome C peroxidase
IVG45_RS01160	COG2205	protein histidine kinase activity
IVG45_RS01160	COG2198	Histidine kinase
IVG45_RS01160	COG0784	Response regulator, receiver
IVG45_RS01165	COG3437	response regulator, receiver
IVG45_RS01170	COG1773	rubredoxin
IVG45_RS01175	COG2271	Major facilitator Superfamily
IVG45_RS01210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IVG45_RS01215	COG0442	prolyl-tRNA aminoacylation
IVG45_RS01225	COG0702	epimerase
IVG45_RS01230	COG0702	epimerase
IVG45_RS01245	COG1045	serine acetyltransferase
IVG45_RS01275	COG0577	efflux transmembrane transporter activity
IVG45_RS01275	COG1136	(ABC) transporter
IVG45_RS01280	COG0577	efflux transmembrane transporter activity
IVG45_RS01280	COG1136	(ABC) transporter
IVG45_RS01290	COG0709	Synthesizes selenophosphate from selenide and ATP
IVG45_RS01295	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IVG45_RS01305	COG3437	response regulator, receiver
IVG45_RS01320	COG1959	2 iron, 2 sulfur cluster binding
IVG45_RS01340	COG0242	peptide deformylase activity
IVG45_RS01360	COG0529	Catalyzes the synthesis of activated sulfate
IVG45_RS01380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IVG45_RS01390	COG0513	Belongs to the DEAD box helicase family
IVG45_RS01420	COG1525	nuclease
IVG45_RS01425	COG2885	chlorophyll binding
IVG45_RS01435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IVG45_RS01455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IVG45_RS01465	COG0138	bifunctional purine biosynthesis protein purh
IVG45_RS01475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IVG45_RS01480	COG0488	(ABC) transporter
IVG45_RS01500	COG2217	Heavy metal translocating P-type atpase
IVG45_RS01525	COG1136	(ABC) transporter
IVG45_RS01525	COG0577	efflux transmembrane transporter activity
IVG45_RS01565	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IVG45_RS01580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IVG45_RS01610	COG2815	serine threonine protein kinase
IVG45_RS01610	COG0515	serine threonine protein kinase
IVG45_RS01620	COG0501	Belongs to the peptidase M48B family
IVG45_RS01630	COG0494	nUDIX hydrolase
IVG45_RS01645	COG0745	RESPONSE REGULATOR receiver
IVG45_RS01650	COG5002	protein histidine kinase activity
IVG45_RS01660	COG5002	protein histidine kinase activity
IVG45_RS01685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IVG45_RS01690	COG3383	formate dehydrogenase (NAD+) activity
IVG45_RS01710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IVG45_RS01720	COG2350	Protein conserved in bacteria
IVG45_RS01725	COG2917	probably involved in intracellular septation
IVG45_RS01740	COG2890	protein-(glutamine-N5) methyltransferase activity
IVG45_RS01760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IVG45_RS01810	COG0714	Associated with various cellular activities
IVG45_RS01830	COG0386	Belongs to the glutathione peroxidase family
IVG45_RS01845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IVG45_RS01855	COG0217	transcriptional regulatory protein
IVG45_RS01860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IVG45_RS01865	COG0632	four-way junction helicase activity
IVG45_RS01870	COG2255	four-way junction helicase activity
IVG45_RS01875	COG0824	Thioesterase
IVG45_RS01895	COG0823	Involved in the tonB-independent uptake of proteins
IVG45_RS01900	COG2885	chlorophyll binding
IVG45_RS01905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IVG45_RS01910	COG0602	queuosine metabolic process
IVG45_RS01915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IVG45_RS01930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IVG45_RS01935	COG1702	phosphate starvation-inducible protein PhoH
IVG45_RS01940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IVG45_RS01945	COG4535	Mg2 and Co2 transporter CorC
IVG45_RS01950	COG3300	MHYT domain
IVG45_RS01950	COG5001	Diguanylate cyclase
IVG45_RS01955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IVG45_RS01960	COG1064	alcohol dehydrogenase
IVG45_RS01970	COG0297	glycogen (starch) synthase activity
IVG45_RS01975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IVG45_RS01980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IVG45_RS01990	COG1640	4-alpha-glucanotransferase
IVG45_RS02005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IVG45_RS02010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IVG45_RS02035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IVG45_RS02040	COG0583	DNA-binding transcription factor activity
IVG45_RS02060	COG0475	glutathione-regulated potassium exporter activity
IVG45_RS02065	COG0306	phosphate transporter
IVG45_RS02075	COG0708	Exodeoxyribonuclease III
IVG45_RS02080	COG0408	coproporphyrinogen oxidase activity
IVG45_RS02085	COG1278	Cold shock
IVG45_RS02105	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IVG45_RS02110	COG2116	formate transmembrane transporter activity
IVG45_RS02120	COG1132	(ABC) transporter
IVG45_RS02125	COG0390	transport system, permease component
IVG45_RS02150	COG1643	Atp-dependent helicase
IVG45_RS02165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IVG45_RS02195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IVG45_RS02200	COG4260	virion core protein, lumpy skin disease virus
IVG45_RS02210	COG3161	chorismate lyase activity
IVG45_RS02225	COG0500	methyltransferase
IVG45_RS02235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IVG45_RS02245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IVG45_RS02250	COG0322	excinuclease ABC activity
IVG45_RS02255	COG1573	uracil-dna glycosylase
IVG45_RS02270	COG1185	polyribonucleotide nucleotidyltransferase activity
IVG45_RS02275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IVG45_RS02280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IVG45_RS02285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IVG45_RS02290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IVG45_RS02295	COG0195	Participates in both transcription termination and antitermination
IVG45_RS02300	COG0779	Required for maturation of 30S ribosomal subunits
IVG45_RS02310	COG5002	protein histidine kinase activity
IVG45_RS02310	COG0784	Response regulator, receiver
IVG45_RS02330	COG1131	(ABC) transporter
IVG45_RS02380	COG3153	acetyltransferase
IVG45_RS02380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IVG45_RS02405	COG2914	Belongs to the UPF0125 (RnfH) family
IVG45_RS02410	COG2867	negative regulation of translational initiation
IVG45_RS02415	COG0733	neurotransmitter:sodium symporter activity
IVG45_RS02420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IVG45_RS02425	COG1335	isochorismatase
IVG45_RS02430	COG1477	protein flavinylation
IVG45_RS02440	COG0135	phosphoribosylanthranilate isomerase activity
IVG45_RS02445	COG0133	tryptophan synthase activity
IVG45_RS02450	COG0159	tryptophan synthase activity
IVG45_RS02455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IVG45_RS02460	COG0285	dihydrofolate synthase activity
IVG45_RS02470	COG1286	toxin biosynthetic process
IVG45_RS02505	COG3264	Mechanosensitive ion channel
IVG45_RS02505	COG1511	domain protein
IVG45_RS02510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IVG45_RS02515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IVG45_RS02515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IVG45_RS02530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IVG45_RS02535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IVG45_RS02545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IVG45_RS02565	COG1538	Outer membrane efflux protein
IVG45_RS02570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IVG45_RS02575	COG3851	Histidine kinase
IVG45_RS02580	COG2197	response regulator
IVG45_RS02585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IVG45_RS02590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IVG45_RS02615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IVG45_RS02620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IVG45_RS02625	COG3108	Peptidase M15
IVG45_RS02635	COG2703	oxygen carrier activity
IVG45_RS02660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IVG45_RS02675	COG2201	protein-glutamate methylesterase activity
IVG45_RS02680	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IVG45_RS02690	COG0840	transmembrane signaling receptor activity
IVG45_RS02705	COG0643	Histidine kinase
IVG45_RS02705	COG2198	Histidine kinase
IVG45_RS02715	COG0835	chemotaxis
IVG45_RS02720	COG0840	transmembrane signaling receptor activity
IVG45_RS02725	COG0835	chemotaxis
IVG45_RS02750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IVG45_RS02755	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IVG45_RS02760	COG5001	Diguanylate cyclase
IVG45_RS02760	COG4251	negative regulation of phosphorylation
IVG45_RS02760	COG3706	GGDEF domain
IVG45_RS02760	COG2203	Gaf domain
IVG45_RS02770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IVG45_RS02805	COG1472	Belongs to the glycosyl hydrolase 3 family
IVG45_RS02845	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IVG45_RS02865	COG3360	Dodecin
IVG45_RS02870	COG0352	thiamine-phosphate diphosphorylase activity
IVG45_RS02875	COG0351	phosphomethylpyrimidine kinase
IVG45_RS02880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IVG45_RS02885	COG0735	belongs to the Fur family
IVG45_RS02890	COG3706	GGDEF domain
IVG45_RS02895	COG0574	Belongs to the PEP-utilizing enzyme family
IVG45_RS02895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IVG45_RS02905	COG3344	reverse transcriptase
IVG45_RS02945	COG0583	DNA-binding transcription factor activity
IVG45_RS02950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IVG45_RS02960	COG5016	pyruvate
IVG45_RS02960	COG0511	ligase activity, forming carbon-carbon bonds
IVG45_RS02965	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IVG45_RS02975	COG1104	cysteine desulfurase activity
IVG45_RS02985	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IVG45_RS02990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IVG45_RS03000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IVG45_RS03005	COG0039	L-malate dehydrogenase activity
IVG45_RS03020	COG0457	Tetratricopeptide repeat
IVG45_RS03055	COG1858	cytochrome C peroxidase
IVG45_RS03075	COG2223	nitrite transmembrane transporter activity
IVG45_RS03085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IVG45_RS03095	COG0045	succinate-CoA ligase (ADP-forming) activity
IVG45_RS03100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IVG45_RS03105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IVG45_RS03140	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IVG45_RS03170	COG3541	Predicted nucleotidyltransferase
IVG45_RS03190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IVG45_RS03290	COG3177	Filamentation induced by cAMP protein fic
IVG45_RS03350	COG1690	Belongs to the RtcB family
IVG45_RS03355	COG2003	Belongs to the UPF0758 family
IVG45_RS03420	COG0629	single-stranded DNA binding
IVG45_RS03515	COG1104	cysteine desulfurase activity
IVG45_RS03540	COG0681	Belongs to the peptidase S26 family
IVG45_RS03595	COG0776	regulation of translation
IVG45_RS03610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IVG45_RS03615	COG0583	DNA-binding transcription factor activity
IVG45_RS03685	COG0776	regulation of translation
IVG45_RS03705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IVG45_RS03715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IVG45_RS03715	COG1773	rubredoxin
IVG45_RS03720	COG1573	uracil-dna glycosylase
IVG45_RS03725	COG1573	uracil-dna glycosylase
IVG45_RS03730	COG3189	MarR family transcriptional regulator
IVG45_RS03755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IVG45_RS03760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IVG45_RS03765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IVG45_RS03935	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
IVG45_RS03940	COG0189	ligase activity
IVG45_RS03950	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
IVG45_RS03970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IVG45_RS03990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IVG45_RS04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IVG45_RS04005	COG0508	dehydrogenase complex catalyzes the overall conversion of
IVG45_RS04025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IVG45_RS04040	COG3328	transposase activity
IVG45_RS04050	COG2205	protein histidine kinase activity
IVG45_RS04055	COG0745	RESPONSE REGULATOR receiver
IVG45_RS04070	COG0840	transmembrane signaling receptor activity
IVG45_RS04085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IVG45_RS04090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IVG45_RS04100	COG1451	nucleotide metabolic process
IVG45_RS04110	COG1872	DUF167
IVG45_RS04145	COG3210	domain, Protein
IVG45_RS04150	COG0811	peptide transport
IVG45_RS04185	COG0513	Belongs to the DEAD box helicase family
IVG45_RS04225	COG0745	RESPONSE REGULATOR receiver
IVG45_RS04230	COG0643	Histidine kinase
IVG45_RS04230	COG2198	Histidine kinase
IVG45_RS04245	COG0835	chemotaxis
IVG45_RS04250	COG1192	Involved in chromosome partitioning
IVG45_RS04265	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IVG45_RS04270	COG2201	protein-glutamate methylesterase activity
IVG45_RS04275	COG0840	transmembrane signaling receptor activity
IVG45_RS04290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IVG45_RS04305	COG1199	ATP-dependent helicase activity
IVG45_RS04310	COG1214	PFAM Peptidase M22, glycoprotease
IVG45_RS04315	COG0009	L-threonylcarbamoyladenylate synthase
IVG45_RS04320	COG1994	Peptidase M50
IVG45_RS04330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IVG45_RS04335	COG1187	pseudouridine synthase activity
IVG45_RS04370	COG3119	arylsulfatase activity
IVG45_RS04405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IVG45_RS04410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IVG45_RS04420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IVG45_RS04425	COG1136	(ABC) transporter
IVG45_RS04425	COG0577	efflux transmembrane transporter activity
IVG45_RS04445	COG0840	transmembrane signaling receptor activity
IVG45_RS04470	COG3706	GGDEF domain
IVG45_RS04475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IVG45_RS04500	COG0653	protein targeting
IVG45_RS04505	COG0457	Tetratricopeptide repeat
IVG45_RS04540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IVG45_RS04545	COG0305	Participates in initiation and elongation during chromosome replication
IVG45_RS04550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IVG45_RS04560	COG4191	Histidine kinase
IVG45_RS04565	COG3300	MHYT domain
IVG45_RS04565	COG5001	Diguanylate cyclase
IVG45_RS04575	COG0835	chemotaxis
IVG45_RS04580	COG0840	transmembrane signaling receptor activity
IVG45_RS04585	COG2198	Histidine kinase
IVG45_RS04585	COG0643	Histidine kinase
IVG45_RS04600	COG2197	response regulator
IVG45_RS04615	COG0826	peptidase U32
IVG45_RS04620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IVG45_RS04625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IVG45_RS04630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IVG45_RS04660	COG0557	exoribonuclease II activity
IVG45_RS04665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IVG45_RS04675	COG0446	pyridine nucleotide-disulphide oxidoreductase
IVG45_RS04690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IVG45_RS04695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IVG45_RS04700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IVG45_RS04705	COG0587	DNA-directed DNA polymerase activity
IVG45_RS04715	COG0436	Aminotransferase
IVG45_RS04725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IVG45_RS04735	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IVG45_RS04745	COG1671	Belongs to the UPF0178 family
IVG45_RS04750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IVG45_RS04775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IVG45_RS04790	COG0456	acetyltransferase
IVG45_RS04795	COG1490	D-aminoacyl-tRNA deacylase activity
IVG45_RS04805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IVG45_RS04810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IVG45_RS04815	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IVG45_RS04820	COG2205	protein histidine kinase activity
IVG45_RS04825	COG0745	RESPONSE REGULATOR receiver
IVG45_RS04830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IVG45_RS04835	COG3852	Histidine kinase
IVG45_RS04840	COG1100	Small GTP-binding protein
IVG45_RS04855	COG0674	pyruvate-flavodoxin oxidoreductase activity
IVG45_RS04855	COG1013	pyruvate-flavodoxin oxidoreductase activity
IVG45_RS04855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IVG45_RS04855	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IVG45_RS04865	COG2081	HI0933 family
IVG45_RS04870	COG0372	Belongs to the citrate synthase family
IVG45_RS04875	COG5508	conserved small protein
IVG45_RS04885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IVG45_RS04890	COG1053	succinate dehydrogenase
IVG45_RS04895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IVG45_RS04910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IVG45_RS04915	COG0070	glutamate synthase
IVG45_RS04915	COG0069	glutamate synthase activity
IVG45_RS04915	COG0067	glutamate synthase
IVG45_RS04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IVG45_RS04925	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IVG45_RS04930	COG0024	Methionine aminopeptidase
IVG45_RS04935	COG0052	Belongs to the universal ribosomal protein uS2 family
IVG45_RS04940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IVG45_RS04945	COG0528	UMP kinase activity
IVG45_RS04950	COG0233	cytoplasmic translational termination
IVG45_RS04960	COG0575	Belongs to the CDS family
IVG45_RS04965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IVG45_RS04975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IVG45_RS04995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IVG45_RS05005	COG0789	Transcriptional regulator
IVG45_RS05015	COG2963	transposase activity
IVG45_RS05055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IVG45_RS05065	COG2076	Multidrug Resistance protein
IVG45_RS05075	COG2920	part of a sulfur-relay system
IVG45_RS05080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IVG45_RS05085	COG1278	Cold shock
IVG45_RS05100	COG0493	'glutamate synthase
IVG45_RS05100	COG0543	2 iron, 2 sulfur cluster binding
IVG45_RS05105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IVG45_RS05110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IVG45_RS05115	COG0671	phosphoesterase, PA-phosphatase related
IVG45_RS05130	COG0509	glycine decarboxylation via glycine cleavage system
IVG45_RS05135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IVG45_RS05140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IVG45_RS05145	COG3956	TIGRFAM MazG family protein
IVG45_RS05155	COG5001	Diguanylate cyclase
IVG45_RS05155	COG3447	MASE1 domain protein
IVG45_RS05155	COG5002	protein histidine kinase activity
IVG45_RS05160	COG0303	'Molybdopterin
IVG45_RS05165	COG1763	Mo-molybdopterin cofactor biosynthetic process
IVG45_RS05170	COG0484	heat shock protein binding
IVG45_RS05175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IVG45_RS05185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IVG45_RS05195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IVG45_RS05205	COG0101	tRNA pseudouridine synthase activity
IVG45_RS05225	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IVG45_RS05260	COG2925	Exonuclease
IVG45_RS05295	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IVG45_RS05315	COG1269	ATP hydrolysis coupled proton transport
IVG45_RS05360	COG4133	protoheme IX ABC transporter activity
IVG45_RS05380	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IVG45_RS05385	COG1138	Cytochrome C-type biogenesis protein
IVG45_RS05470	COG3040	lipid binding
IVG45_RS05475	COG0415	Belongs to the DNA photolyase family
IVG45_RS05485	COG1090	epimerase
IVG45_RS05490	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IVG45_RS05505	COG2202	Pas domain
IVG45_RS05505	COG1366	Belongs to the anti-sigma-factor antagonist family
IVG45_RS05525	COG0330	HflC and HflK could
IVG45_RS05530	COG0330	HflC and HflK could
IVG45_RS05535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IVG45_RS05555	COG2205	protein histidine kinase activity
IVG45_RS05555	COG4191	Histidine kinase
IVG45_RS05555	COG0745	RESPONSE REGULATOR receiver
IVG45_RS05565	COG4191	Histidine kinase
IVG45_RS05570	COG0745	RESPONSE REGULATOR receiver
IVG45_RS05580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IVG45_RS05585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IVG45_RS05585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IVG45_RS05595	COG2923	Belongs to the DsrF TusC family
IVG45_RS05600	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IVG45_RS05605	COG4783	chaperone-mediated protein folding
IVG45_RS05610	COG2409	Drug exporters of the RND superfamily
IVG45_RS05620	COG2833	Protein of unknown function (DUF455)
IVG45_RS05625	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IVG45_RS05675	COG0456	acetyltransferase
IVG45_RS05680	COG2808	Putative FMN-binding domain
IVG45_RS05695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IVG45_RS05745	COG0431	NADPH-dependent FMN reductase
IVG45_RS05755	COG2197	response regulator
IVG45_RS05770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IVG45_RS05775	COG4106	trans-aconitate 2-methyltransferase activity
IVG45_RS05805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IVG45_RS05810	COG0697	spore germination
IVG45_RS05815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IVG45_RS05830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IVG45_RS05850	COG0306	phosphate transporter
IVG45_RS05855	COG2226	methyltransferase
IVG45_RS05860	COG1595	DNA-templated transcription, initiation
IVG45_RS05870	COG0535	radical SAM domain protein
IVG45_RS05880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IVG45_RS05885	COG1238	metal cluster binding
IVG45_RS05905	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IVG45_RS05910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IVG45_RS05935	COG2871	sodium ion transport
IVG45_RS05940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IVG45_RS05945	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IVG45_RS05950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IVG45_RS05970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IVG45_RS05975	COG3459	Glycosyltransferase 36 associated
IVG45_RS05995	COG2274	protein secretion by the type I secretion system
IVG45_RS06000	COG1943	Transposase
IVG45_RS06020	COG1943	Transposase
IVG45_RS06105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IVG45_RS06110	COG4716	Myosin-crossreactive antigen
IVG45_RS06125	COG2885	chlorophyll binding
IVG45_RS06145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IVG45_RS06155	COG1657	PFAM Prenyltransferase squalene oxidase
IVG45_RS06190	COG2823	Periplasmic or secreted lipoprotein
IVG45_RS06230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IVG45_RS06235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IVG45_RS06240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IVG45_RS06255	COG0776	regulation of translation
IVG45_RS06265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IVG45_RS06270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IVG45_RS06275	COG0287	Prephenate dehydrogenase
IVG45_RS06280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IVG45_RS06290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IVG45_RS06305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IVG45_RS06335	COG0280	phosphate acetyltransferase
IVG45_RS06335	COG0857	belongs to the CobB CobQ family
IVG45_RS06345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IVG45_RS06350	COG5001	Diguanylate cyclase
IVG45_RS06360	COG1253	flavin adenine dinucleotide binding
IVG45_RS06370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IVG45_RS06390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IVG45_RS06390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IVG45_RS06395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IVG45_RS06415	COG0745	RESPONSE REGULATOR receiver
IVG45_RS06430	COG5001	Diguanylate cyclase
IVG45_RS06430	COG3300	MHYT domain
IVG45_RS06450	COG2204	response regulator
IVG45_RS06460	COG4251	negative regulation of phosphorylation
IVG45_RS06470	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IVG45_RS06475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IVG45_RS06520	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS06550	COG1132	(ABC) transporter
IVG45_RS06575	COG2197	response regulator
IVG45_RS06590	COG5002	protein histidine kinase activity
IVG45_RS06590	COG2198	Histidine kinase
IVG45_RS06590	COG0784	Response regulator, receiver
IVG45_RS06595	COG0123	including yeast histone deacetylase and acetoin utilization protein
IVG45_RS06625	COG1966	Carbon starvation protein
IVG45_RS06650	COG1639	'signal transduction protein
IVG45_RS06670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IVG45_RS06675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IVG45_RS06680	COG3026	antisigma factor binding
IVG45_RS06695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IVG45_RS06730	COG1450	Type ii and iii secretion system protein
IVG45_RS06750	COG3156	type II secretion system protein K
IVG45_RS06760	COG2165	general secretion pathway protein
IVG45_RS06775	COG1459	type II secretion system
IVG45_RS06800	COG4206	TonB-dependent receptor
IVG45_RS06805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IVG45_RS06820	COG0436	Aminotransferase
IVG45_RS06830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IVG45_RS06835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IVG45_RS06845	COG3328	transposase activity
IVG45_RS06855	COG1461	Dihydroxyacetone kinase
IVG45_RS06860	COG2376	Dihydroxyacetone kinase
IVG45_RS06865	COG0647	UMP catabolic process
IVG45_RS06890	COG2197	response regulator
IVG45_RS06900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IVG45_RS06905	COG1301	dicarboxylic acid transport
IVG45_RS06910	COG3012	SEC-C Motif Domain Protein
IVG45_RS06915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IVG45_RS06930	COG4772	TonB-dependent receptor
IVG45_RS06965	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IVG45_RS06975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IVG45_RS06980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IVG45_RS07000	COG0247	lactate metabolic process
IVG45_RS07025	COG3411	Ferredoxin
IVG45_RS07085	COG2914	Belongs to the UPF0125 (RnfH) family
IVG45_RS07100	COG4658	electron transport chain
IVG45_RS07105	COG4656	Part of a membrane complex involved in electron transport
IVG45_RS07110	COG2878	Part of a membrane complex involved in electron transport
IVG45_RS07115	COG4657	Part of a membrane complex involved in electron transport
IVG45_RS07130	COG0330	HflC and HflK could
IVG45_RS07135	COG0330	HflC and HflK could
IVG45_RS07140	COG1047	Peptidyl-prolyl cis-trans
IVG45_RS07165	COG1473	amidohydrolase
IVG45_RS07215	COG2165	general secretion pathway protein
IVG45_RS07265	COG2078	PFAM AMMECR1 domain protein
IVG45_RS07275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IVG45_RS07280	COG1074	ATP-dependent DNA helicase activity
IVG45_RS07285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IVG45_RS07340	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IVG45_RS07345	COG1309	transcriptional regulator
IVG45_RS07350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IVG45_RS07360	COG1538	Outer membrane efflux protein
IVG45_RS07370	COG0019	diaminopimelate decarboxylase activity
IVG45_RS07375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IVG45_RS07380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IVG45_RS07385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IVG45_RS07390	COG0860	N-Acetylmuramoyl-L-alanine amidase
IVG45_RS07395	COG0802	atpase or kinase
IVG45_RS07400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IVG45_RS07400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IVG45_RS07410	COG0436	Aminotransferase
IVG45_RS07415	COG5002	protein histidine kinase activity
IVG45_RS07415	COG2198	Histidine kinase
IVG45_RS07415	COG0784	Response regulator, receiver
IVG45_RS07425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IVG45_RS07440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IVG45_RS07460	COG3086	response to oxidative stress
IVG45_RS07480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IVG45_RS07540	COG0569	domain protein
IVG45_RS07540	COG2985	domain, Protein
IVG45_RS07585	COG0784	Response regulator, receiver
IVG45_RS07585	COG5002	protein histidine kinase activity
IVG45_RS07595	COG2963	transposase activity
IVG45_RS07615	COG1543	Belongs to the glycosyl hydrolase 57 family
IVG45_RS07640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IVG45_RS07645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IVG45_RS07650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IVG45_RS07655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IVG45_RS07660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IVG45_RS07665	COG0072	phenylalanine-tRNA ligase activity
IVG45_RS07665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IVG45_RS07695	COG2963	transposase activity
IVG45_RS07700	COG5583	Uncharacterized small protein (DUF2292)
IVG45_RS07710	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IVG45_RS07715	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IVG45_RS07720	COG4208	sulfate ABC transporter
IVG45_RS07725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IVG45_RS07760	COG4771	TonB-dependent receptor
IVG45_RS07820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IVG45_RS07825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IVG45_RS07865	COG3909	cytochrome
IVG45_RS07875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IVG45_RS07880	COG1045	serine acetyltransferase
IVG45_RS07885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IVG45_RS07890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IVG45_RS07950	COG5002	protein histidine kinase activity
IVG45_RS07950	COG0784	Response regulator, receiver
IVG45_RS07950	COG2198	Histidine kinase
IVG45_RS07955	COG5002	protein histidine kinase activity
IVG45_RS07955	COG0784	Response regulator, receiver
IVG45_RS07960	COG0784	Response regulator, receiver
IVG45_RS07960	COG5002	protein histidine kinase activity
IVG45_RS07965	COG5002	protein histidine kinase activity
IVG45_RS07965	COG0784	Response regulator, receiver
IVG45_RS07980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IVG45_RS07985	COG0402	S-adenosylhomocysteine deaminase activity
IVG45_RS07990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IVG45_RS08035	COG4636	protein conserved in cyanobacteria
IVG45_RS08045	COG0686	Belongs to the AlaDH PNT family
IVG45_RS08065	COG2204	response regulator
IVG45_RS08070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IVG45_RS08085	COG3123	guanosine phosphorylase activity
IVG45_RS08090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IVG45_RS08095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IVG45_RS08095	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IVG45_RS08125	COG0613	PHP domain protein
IVG45_RS08130	COG1132	(ABC) transporter
IVG45_RS08135	COG0741	lytic transglycosylase activity
IVG45_RS08135	COG0739	heme binding
IVG45_RS08135	COG1196	nuclear chromosome segregation
IVG45_RS08140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IVG45_RS08150	COG0037	tRNA processing
IVG45_RS08155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IVG45_RS08160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IVG45_RS08185	COG2197	response regulator
IVG45_RS08190	COG2197	response regulator
IVG45_RS08205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IVG45_RS08210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IVG45_RS08215	COG1881	PFAM PEBP family protein
IVG45_RS08220	COG3706	GGDEF domain
IVG45_RS08225	COG1049	propionate catabolic process, 2-methylcitrate cycle
IVG45_RS08230	COG4636	protein conserved in cyanobacteria
IVG45_RS08235	COG0473	3-isopropylmalate dehydrogenase activity
IVG45_RS08255	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS08260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IVG45_RS08270	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS08280	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS08285	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS08335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IVG45_RS08390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IVG45_RS08430	COG1355	regulation of microtubule-based process
IVG45_RS08435	COG3885	ferrous iron binding
IVG45_RS08435	COG2078	PFAM AMMECR1 domain protein
IVG45_RS08450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IVG45_RS08455	COG0363	glucosamine-6-phosphate deaminase activity
IVG45_RS08470	COG0800	Aldolase
IVG45_RS08480	COG3038	cytochrome b561
IVG45_RS08490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IVG45_RS08505	COG3852	Histidine kinase
IVG45_RS08510	COG2204	response regulator
IVG45_RS08520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IVG45_RS08525	COG0514	ATP-dependent DNA helicase (RecQ)
IVG45_RS08535	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IVG45_RS08535	COG1672	PFAM Archaeal ATPase
IVG45_RS08545	COG3710	Transcriptional regulator
IVG45_RS08545	COG0457	Tetratricopeptide repeat
IVG45_RS08600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IVG45_RS08605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IVG45_RS08620	COG0556	nucleotide-excision repair
IVG45_RS08625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IVG45_RS08630	COG1595	DNA-templated transcription, initiation
IVG45_RS08640	COG2963	transposase activity
IVG45_RS08665	COG0513	Belongs to the DEAD box helicase family
IVG45_RS08695	COG3267	Type II secretory pathway component ExeA
IVG45_RS08695	COG3409	Peptidoglycan-binding domain 1 protein
IVG45_RS08705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IVG45_RS08710	COG1459	type II secretion system
IVG45_RS08725	COG2165	general secretion pathway protein
IVG45_RS08750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IVG45_RS08755	COG0321	lipoyl(octanoyl) transferase activity
IVG45_RS08760	COG2921	Belongs to the UPF0250 family
IVG45_RS08770	COG1686	Belongs to the peptidase S11 family
IVG45_RS08780	COG2826	transposase and inactivated derivatives, IS30 family
IVG45_RS08790	COG3961	Belongs to the TPP enzyme family
IVG45_RS08830	COG0628	permease
IVG45_RS08845	COG2982	Protein involved in outer membrane biogenesis
IVG45_RS08855	COG0753	catalase activity
IVG45_RS08860	COG3608	succinylglutamate desuccinylase aspartoacylase
IVG45_RS08860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IVG45_RS08875	COG2080	2 iron, 2 sulfur cluster binding
IVG45_RS08880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IVG45_RS08885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IVG45_RS08890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IVG45_RS08905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IVG45_RS08915	COG2814	Major facilitator Superfamily
IVG45_RS08945	COG0463	Glycosyl transferase, family 2
IVG45_RS08965	COG0489	protein tyrosine kinase activity
IVG45_RS08965	COG3206	protein involved in exopolysaccharide biosynthesis
IVG45_RS08970	COG1596	polysaccharide export
IVG45_RS08990	COG0842	Transport permease protein
IVG45_RS08995	COG1131	(ABC) transporter
IVG45_RS09025	COG1570	exodeoxyribonuclease VII activity
IVG45_RS09030	COG0739	heme binding
IVG45_RS09040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IVG45_RS09045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IVG45_RS09060	COG0616	signal peptide processing
IVG45_RS09060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IVG45_RS09065	COG0546	phosphoglycolate phosphatase activity
IVG45_RS09070	COG0564	pseudouridine synthase activity
IVG45_RS09075	COG1530	ribonuclease E activity
IVG45_RS09080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IVG45_RS09085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IVG45_RS09095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IVG45_RS09100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IVG45_RS09115	COG0840	transmembrane signaling receptor activity
IVG45_RS09160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IVG45_RS09170	COG0673	inositol 2-dehydrogenase activity
IVG45_RS09175	COG2217	Heavy metal translocating P-type atpase
IVG45_RS09185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IVG45_RS09195	COG2915	High frequency lysogenization protein hflD homolog
IVG45_RS09200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IVG45_RS09225	COG0628	permease
IVG45_RS09255	COG1797	cobyrinic acid a,c-diamide synthase activity
IVG45_RS09270	COG1674	ftsk spoiiie
IVG45_RS09275	COG0492	ferredoxin-NADP+ reductase activity
IVG45_RS09285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IVG45_RS09295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IVG45_RS09300	COG1518	maintenance of DNA repeat elements
IVG45_RS09350	COG3712	iron ion homeostasis
IVG45_RS09355	COG1595	DNA-templated transcription, initiation
IVG45_RS09360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IVG45_RS09365	COG0542	response to heat
IVG45_RS09370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IVG45_RS09380	COG0482	sulfurtransferase activity
IVG45_RS09385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IVG45_RS09395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IVG45_RS09400	COG2715	membrane protein required for spore maturation
IVG45_RS09405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IVG45_RS09415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IVG45_RS09420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IVG45_RS09435	COG0495	leucyl-tRNA aminoacylation
IVG45_RS09445	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
IVG45_RS09455	COG1970	mechanosensitive ion channel activity
IVG45_RS09485	COG1131	(ABC) transporter
IVG45_RS09495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IVG45_RS09530	COG0745	RESPONSE REGULATOR receiver
IVG45_RS09535	COG2205	protein histidine kinase activity
IVG45_RS09540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IVG45_RS09545	COG2824	Alkylphosphonate utilization operon protein PhnA
IVG45_RS09560	COG0659	secondary active sulfate transmembrane transporter activity
IVG45_RS09565	COG0643	Histidine kinase
IVG45_RS09565	COG2198	Histidine kinase
IVG45_RS09570	COG0840	transmembrane signaling receptor activity
IVG45_RS09570	COG0840	transmembrane signaling receptor activity
IVG45_RS09585	COG4974	Belongs to the 'phage' integrase family
IVG45_RS09670	COG0582	viral genome integration into host DNA
IVG45_RS09685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IVG45_RS09690	COG3001	Fructosamine kinase
IVG45_RS09715	COG3437	response regulator, receiver
IVG45_RS09725	COG4191	Histidine kinase
IVG45_RS09730	COG0745	RESPONSE REGULATOR receiver
IVG45_RS09740	COG5001	Diguanylate cyclase
IVG45_RS09740	COG5002	protein histidine kinase activity
IVG45_RS09765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IVG45_RS09770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IVG45_RS09775	COG0330	HflC and HflK could
IVG45_RS09780	COG0330	HflC and HflK could
IVG45_RS09785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IVG45_RS09790	COG1923	regulation of RNA biosynthetic process
IVG45_RS09795	COG0488	(ABC) transporter
IVG45_RS09825	COG0084	hydrolase, TatD family'
IVG45_RS09900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IVG45_RS09905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IVG45_RS09910	COG0501	Belongs to the peptidase M48B family
IVG45_RS09915	COG1162	GTPase activity
IVG45_RS09920	COG0537	adenosine 5'-monophosphoramidase activity
IVG45_RS09925	COG0151	Belongs to the GarS family
IVG45_RS09930	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IVG45_RS09935	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IVG45_RS09960	COG3118	belongs to the thioredoxin family
IVG45_RS09980	COG1773	rubredoxin
IVG45_RS09995	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IVG45_RS10000	COG0375	protein maturation
IVG45_RS10010	COG1196	nuclear chromosome segregation
IVG45_RS10015	COG2963	transposase activity
IVG45_RS10050	COG0409	Hydrogenase expression formation protein
IVG45_RS10065	COG0309	Hydrogenase expression formation protein (HypE)
IVG45_RS10070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IVG45_RS10075	COG0746	molybdenum cofactor guanylyltransferase activity
IVG45_RS10110	COG3179	chitinase
IVG45_RS10140	COG5002	protein histidine kinase activity
IVG45_RS10140	COG3850	Histidine kinase
IVG45_RS10150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IVG45_RS10155	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IVG45_RS10170	COG2835	tetraacyldisaccharide 4'-kinase activity
IVG45_RS10175	COG1663	tetraacyldisaccharide 4'-kinase activity
IVG45_RS10180	COG0848	biopolymer transport protein
IVG45_RS10185	COG0811	peptide transport
IVG45_RS10195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IVG45_RS10210	COG1758	RNA polymerase activity
IVG45_RS10215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IVG45_RS10225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IVG45_RS10250	COG2373	Large extracellular alpha-helical protein
IVG45_RS10325	COG1136	(ABC) transporter
IVG45_RS10335	COG0735	belongs to the Fur family
IVG45_RS10340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IVG45_RS10345	COG4191	Histidine kinase
IVG45_RS10350	COG2204	response regulator
IVG45_RS10355	COG0745	RESPONSE REGULATOR receiver
IVG45_RS10360	COG3437	response regulator, receiver
IVG45_RS10380	COG3876	Protein conserved in bacteria
IVG45_RS10390	COG0726	polysaccharide deacetylase
IVG45_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
IVG45_RS10425	COG0840	transmembrane signaling receptor activity
IVG45_RS10435	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS10470	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS10475	COG1216	Glycosyl transferase, family 2
IVG45_RS10480	COG0463	Glycosyl transferase, family 2
IVG45_RS10490	COG0726	polysaccharide deacetylase
IVG45_RS10495	COG1216	Glycosyl transferase, family 2
IVG45_RS10510	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS10525	COG3119	arylsulfatase activity
IVG45_RS10530	COG2983	Belongs to the UPF0260 family
IVG45_RS10535	COG2177	Part of the ABC transporter FtsEX involved in
IVG45_RS10540	COG2884	Cell division ATP-binding protein ftsE
IVG45_RS10550	COG0552	protein localization to endoplasmic reticulum
IVG45_RS10580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IVG45_RS10590	COG2703	oxygen carrier activity
IVG45_RS10595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IVG45_RS10600	COG2226	methyltransferase
IVG45_RS10600	COG2267	carboxylic ester hydrolase activity
IVG45_RS10610	COG0156	8-amino-7-oxononanoate synthase activity
IVG45_RS10615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IVG45_RS10635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IVG45_RS10640	COG1902	pentaerythritol trinitrate reductase activity
IVG45_RS10665	COG0629	single-stranded DNA binding
IVG45_RS10670	COG2814	Major facilitator Superfamily
IVG45_RS10685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IVG45_RS10750	COG2963	transposase activity
IVG45_RS10780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IVG45_RS10785	COG0583	DNA-binding transcription factor activity
IVG45_RS10795	COG1051	belongs to the nudix hydrolase family
IVG45_RS10800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IVG45_RS10805	COG0494	nUDIX hydrolase
IVG45_RS10815	COG0425	Belongs to the sulfur carrier protein TusA family
IVG45_RS10820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IVG45_RS10820	COG1648	precorrin-2 dehydrogenase activity
IVG45_RS10835	COG0137	argininosuccinate synthase activity
IVG45_RS10840	COG1519	Transferase
IVG45_RS10865	COG0574	Belongs to the PEP-utilizing enzyme family
IVG45_RS10865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IVG45_RS10870	COG2205	protein histidine kinase activity
IVG45_RS10870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IVG45_RS10880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IVG45_RS10885	COG0359	binds to the 23S rRNA
IVG45_RS10895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IVG45_RS10900	COG0360	Binds together with S18 to 16S ribosomal RNA
IVG45_RS10935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IVG45_RS10965	COG4536	flavin adenine dinucleotide binding
IVG45_RS10970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IVG45_RS10975	COG0546	phosphoglycolate phosphatase activity
IVG45_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
IVG45_RS10985	COG2151	metal-sulfur cluster biosynthetic enzyme
IVG45_RS10995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IVG45_RS11010	COG0316	Belongs to the HesB IscA family
IVG45_RS11020	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS11025	COG0726	polysaccharide deacetylase
IVG45_RS11025	COG1649	PFAM Uncharacterised BCR, COG1649
IVG45_RS11035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IVG45_RS11045	COG1253	flavin adenine dinucleotide binding
IVG45_RS11050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IVG45_RS11060	COG0243	molybdopterin cofactor binding
IVG45_RS11065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IVG45_RS11075	COG1116	anion transmembrane transporter activity
IVG45_RS11075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IVG45_RS11080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IVG45_RS11085	COG1116	anion transmembrane transporter activity
IVG45_RS11085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IVG45_RS11095	COG0126	phosphoglycerate kinase activity
IVG45_RS11155	COG0582	viral genome integration into host DNA
IVG45_RS11200	COG0714	Associated with various cellular activities
IVG45_RS11210	COG2010	Cytochrome c
IVG45_RS11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IVG45_RS11220	COG4993	Dehydrogenase
IVG45_RS11245	COG4771	TonB-dependent receptor
IVG45_RS11270	COG1229	Formylmethanofuran dehydrogenase subunit A
IVG45_RS11275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IVG45_RS11285	COG1469	GTP cyclohydrolase I activity
IVG45_RS11290	COG0523	cobalamin synthesis protein
IVG45_RS11330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IVG45_RS11360	COG3128	pkhd-type hydroxylase
IVG45_RS11370	COG4774	siderophore transport
IVG45_RS11395	COG4256	Hemin uptake protein
IVG45_RS11405	COG2091	lysine biosynthetic process via aminoadipic acid
IVG45_RS11410	COG0028	Belongs to the TPP enzyme family
IVG45_RS11420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IVG45_RS11430	COG1183	phosphatidylcholine synthase activity
IVG45_RS11450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IVG45_RS11455	COG1858	cytochrome C peroxidase
IVG45_RS11460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IVG45_RS11465	COG0825	malonyl-CoA metabolic process
IVG45_RS11470	COG0037	tRNA processing
IVG45_RS11485	COG0504	CTP synthase activity
IVG45_RS11490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IVG45_RS11495	COG0148	phosphopyruvate hydratase activity
IVG45_RS11500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IVG45_RS11510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IVG45_RS11515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IVG45_RS11520	COG0585	pseudouridine synthase activity
IVG45_RS11530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IVG45_RS11535	COG3178	'Phosphotransferase
IVG45_RS11540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IVG45_RS11545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IVG45_RS11555	COG4772	TonB-dependent receptor
IVG45_RS11560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IVG45_RS11570	COG2119	membrane
IVG45_RS11580	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IVG45_RS11585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IVG45_RS11590	COG1509	lysine 2,3-aminomutase activity
IVG45_RS11595	COG2205	protein histidine kinase activity
IVG45_RS11595	COG3850	Histidine kinase
IVG45_RS11595	COG4999	Histidine kinase
IVG45_RS11595	COG3437	response regulator, receiver
IVG45_RS11600	COG3706	GGDEF domain
IVG45_RS11600	COG4251	negative regulation of phosphorylation
IVG45_RS11600	COG5001	Diguanylate cyclase
IVG45_RS11600	COG2203	Gaf domain
IVG45_RS11625	COG1381	Involved in DNA repair and RecF pathway recombination
IVG45_RS11630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IVG45_RS11635	COG0571	ribonuclease III activity
IVG45_RS11645	COG0681	Belongs to the peptidase S26 family
IVG45_RS11650	COG0481	GTPase activity
IVG45_RS11660	COG1196	nuclear chromosome segregation
IVG45_RS11665	COG1649	PFAM Uncharacterised BCR, COG1649
IVG45_RS11665	COG0726	polysaccharide deacetylase
IVG45_RS11680	COG3256	nitric oxide reductase
IVG45_RS11685	COG2010	Cytochrome c
IVG45_RS11700	COG0459	protein refolding
IVG45_RS11705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IVG45_RS11745	COG0596	Alpha beta hydrolase
IVG45_RS11745	COG0508	dehydrogenase complex catalyzes the overall conversion of
IVG45_RS11780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IVG45_RS11785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IVG45_RS11790	COG0006	proline dipeptidase activity
IVG45_RS11795	COG3079	Belongs to the UPF0149 family
IVG45_RS11820	COG0583	DNA-binding transcription factor activity
IVG45_RS11830	COG2814	Major facilitator Superfamily
IVG45_RS11835	COG1538	Outer membrane efflux protein
IVG45_RS11840	COG1566	PFAM secretion protein HlyD family protein
IVG45_RS11875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IVG45_RS11930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IVG45_RS11980	COG2963	transposase activity
IVG45_RS12015	COG2963	transposase activity
IVG45_RS12020	COG5001	Diguanylate cyclase
IVG45_RS12020	COG5002	protein histidine kinase activity
IVG45_RS12035	COG0582	viral genome integration into host DNA
IVG45_RS12145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IVG45_RS12170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IVG45_RS12275	COG3012	SEC-C Motif Domain Protein
IVG45_RS12330	COG0681	Belongs to the peptidase S26 family
IVG45_RS12370	COG4804	nuclease activity
IVG45_RS12400	COG0629	single-stranded DNA binding
IVG45_RS12535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IVG45_RS12545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IVG45_RS12555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IVG45_RS12565	COG0418	dihydroorotase activity
IVG45_RS12575	COG0463	Glycosyl transferase, family 2
IVG45_RS12580	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IVG45_RS12580	COG3952	Lipid A Biosynthesis
IVG45_RS12590	COG0165	Argininosuccinate lyase
IVG45_RS12600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IVG45_RS12605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IVG45_RS12610	COG0416	fatty acid biosynthetic process
IVG45_RS12615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IVG45_RS12625	COG0424	maF-like protein
IVG45_RS12635	COG0741	lytic transglycosylase activity
IVG45_RS12640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IVG45_RS12645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IVG45_RS12650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IVG45_RS12655	COG0302	gtp cyclohydrolase
IVG45_RS12660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IVG45_RS12670	COG5001	Diguanylate cyclase
IVG45_RS12680	COG1131	(ABC) transporter
IVG45_RS12685	COG0842	Transport permease protein
IVG45_RS12690	COG0842	Transport permease protein
IVG45_RS12695	COG0784	Response regulator, receiver
IVG45_RS12695	COG2198	Histidine kinase
IVG45_RS12695	COG5002	protein histidine kinase activity
IVG45_RS12710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IVG45_RS12725	COG0659	secondary active sulfate transmembrane transporter activity
IVG45_RS12730	COG3002	Belongs to the UPF0753 family
IVG45_RS12735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IVG45_RS12750	COG0356	it plays a direct role in the translocation of protons across the membrane
IVG45_RS12760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IVG45_RS12760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IVG45_RS12765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IVG45_RS12775	COG0784	Response regulator, receiver
IVG45_RS12775	COG2198	Histidine kinase
IVG45_RS12775	COG2205	protein histidine kinase activity
IVG45_RS12790	COG0784	Response regulator, receiver
IVG45_RS12795	COG4251	negative regulation of phosphorylation
IVG45_RS12800	COG4251	negative regulation of phosphorylation
IVG45_RS12805	COG2205	protein histidine kinase activity
IVG45_RS12805	COG0784	Response regulator, receiver
IVG45_RS12835	COG0633	Ferredoxin
IVG45_RS12840	COG0426	domain, Protein
IVG45_RS12875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IVG45_RS12880	COG4636	protein conserved in cyanobacteria
IVG45_RS12885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IVG45_RS12895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IVG45_RS12900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IVG45_RS12910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IVG45_RS12920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IVG45_RS12930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IVG45_RS12940	COG0742	ribosomal rna small subunit methyltransferase
IVG45_RS12950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IVG45_RS12960	COG0719	Fe-S assembly protein
IVG45_RS12965	COG0396	ATPase activity
IVG45_RS12970	COG3781	membrane
IVG45_RS12975	COG0719	Fe-S assembly protein
IVG45_RS12980	COG1959	2 iron, 2 sulfur cluster binding
IVG45_RS12990	COG0704	Plays a role in the regulation of phosphate uptake
IVG45_RS13000	COG2132	Multicopper oxidase
IVG45_RS13005	COG0456	acetyltransferase
IVG45_RS13010	COG1573	uracil-dna glycosylase
IVG45_RS13015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IVG45_RS13050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IVG45_RS13060	COG4636	protein conserved in cyanobacteria
IVG45_RS13065	COG2226	methyltransferase
IVG45_RS13075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IVG45_RS13080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IVG45_RS13090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IVG45_RS13195	COG3437	response regulator, receiver
IVG45_RS13205	COG2161	toxin-antitoxin pair type II binding
IVG45_RS13225	COG0590	tRNA wobble adenosine to inosine editing
IVG45_RS13230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IVG45_RS13245	COG2900	Belongs to the SlyX family
IVG45_RS13250	COG1686	Belongs to the peptidase S11 family
IVG45_RS13260	COG4977	sequence-specific DNA binding
IVG45_RS13265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IVG45_RS13265	COG1024	Enoyl-CoA hydratase
IVG45_RS13275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IVG45_RS13285	COG2200	EAL domain
IVG45_RS13300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IVG45_RS13305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IVG45_RS13330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IVG45_RS13335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IVG45_RS13345	COG0842	Transport permease protein
IVG45_RS13350	COG1131	(ABC) transporter
IVG45_RS13355	COG0248	Ppx GppA phosphatase
IVG45_RS13365	COG0745	RESPONSE REGULATOR receiver
IVG45_RS13375	COG1858	cytochrome C peroxidase
IVG45_RS13390	COG1472	Belongs to the glycosyl hydrolase 3 family
IVG45_RS13395	COG0217	transcriptional regulatory protein
IVG45_RS13400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IVG45_RS13400	COG2755	lipolytic protein G-D-S-L family
IVG45_RS13405	COG0488	(ABC) transporter
IVG45_RS13430	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IVG45_RS13470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IVG45_RS13475	COG1704	LemA family
IVG45_RS13530	COG1278	Cold shock
IVG45_RS13585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IVG45_RS13595	COG0154	amidase activity
IVG45_RS13600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IVG45_RS13605	COG1077	Cell shape determining protein MreB Mrl
IVG45_RS13610	COG1792	Involved in formation and maintenance of cell shape
IVG45_RS13615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IVG45_RS13620	COG0768	penicillin binding
IVG45_RS13625	COG0772	Belongs to the SEDS family
IVG45_RS13630	COG2951	lytic endotransglycosylase activity
IVG45_RS13645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IVG45_RS13660	COG1706	bacterial-type flagellum-dependent cell motility
IVG45_RS13665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IVG45_RS13670	COG4786	Flagellar basal body rod
IVG45_RS13675	COG4787	bacterial-type flagellum-dependent cell motility
IVG45_RS13685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IVG45_RS13700	COG0784	Response regulator, receiver
IVG45_RS13700	COG0835	chemotaxis
IVG45_RS13765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IVG45_RS13800	COG0514	ATP-dependent DNA helicase (RecQ)
IVG45_RS13805	COG2918	glutathione biosynthetic process
IVG45_RS13820	COG4636	protein conserved in cyanobacteria
IVG45_RS13850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IVG45_RS13860	COG2264	protein methyltransferase activity
IVG45_RS13865	COG0439	Biotin carboxylase
IVG45_RS13870	COG0511	ligase activity, forming carbon-carbon bonds
IVG45_RS13875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IVG45_RS13880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IVG45_RS13885	COG4232	protein-disulfide reductase activity
IVG45_RS13890	COG1324	tolerance protein
IVG45_RS13905	COG0210	DNA helicase
IVG45_RS13930	COG3328	transposase activity
IVG45_RS13955	COG2072	flavoprotein involved in K transport
IVG45_RS13960	COG0469	pyruvate kinase activity
IVG45_RS13965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IVG45_RS13980	COG2226	methyltransferase
IVG45_RS13990	COG0242	peptide deformylase activity
IVG45_RS13995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IVG45_RS14010	COG5000	phosphorelay sensor kinase activity
IVG45_RS14015	COG2204	response regulator
IVG45_RS14025	COG0204	Acyl-transferase
IVG45_RS14030	COG4589	Belongs to the CDS family
IVG45_RS14035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IVG45_RS14040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IVG45_RS14045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IVG45_RS14075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IVG45_RS14080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IVG45_RS14090	COG1666	GTP binding
IVG45_RS14105	COG0433	COG0433 Predicted ATPase
IVG45_RS14125	COG1067	ATP-dependent peptidase activity
IVG45_RS14150	COG1451	nucleotide metabolic process
IVG45_RS14155	COG2346	COG2346, Truncated hemoglobins
IVG45_RS14180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IVG45_RS14210	COG2183	response to ionizing radiation
IVG45_RS14220	COG0419	ATPase involved in DNA repair
IVG45_RS14240	COG3260	NADH ubiquinone oxidoreductase 20
IVG45_RS14245	COG0649	NAD binding
IVG45_RS14250	COG0651	ATP synthesis coupled electron transport
IVG45_RS14260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IVG45_RS14265	COG0651	ATP synthesis coupled electron transport
IVG45_RS14270	COG0569	domain protein
IVG45_RS14290	COG3622	Belongs to the hyi family
IVG45_RS14295	COG2084	Dehydrogenase
IVG45_RS14305	COG4772	TonB-dependent receptor
IVG45_RS14320	COG0328	RNA-DNA hybrid ribonuclease activity
IVG45_RS14325	COG2226	methyltransferase
IVG45_RS14330	COG0741	lytic transglycosylase activity
IVG45_RS14330	COG1388	LysM domain
IVG45_RS14335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IVG45_RS14340	COG0326	Molecular chaperone. Has ATPase activity
IVG45_RS14375	COG0343	queuine tRNA-ribosyltransferase activity
IVG45_RS14395	COG1252	NADH dehydrogenase
IVG45_RS14405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IVG45_RS14415	COG0300	oxidoreductase activity
IVG45_RS14430	COG1615	UPF0182 protein
IVG45_RS14435	COG2132	Multicopper oxidase
IVG45_RS14470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IVG45_RS14475	COG1333	cytochrome c biogenesis protein
IVG45_RS14485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IVG45_RS14500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IVG45_RS14505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IVG45_RS14520	COG0542	response to heat
IVG45_RS14525	COG1278	Cold shock
IVG45_RS14545	COG2951	lytic endotransglycosylase activity
IVG45_RS14570	COG0538	isocitrate dehydrogenase activity
IVG45_RS14575	COG3239	Fatty acid desaturase
IVG45_RS14605	COG1136	(ABC) transporter
IVG45_RS14625	COG0795	lipopolysaccharide-transporting ATPase activity
IVG45_RS14630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IVG45_RS14685	COG0748	coenzyme F420 binding
IVG45_RS14690	COG0519	Catalyzes the synthesis of GMP from XMP
IVG45_RS14700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IVG45_RS14715	COG3240	lipase activity
IVG45_RS14715	COG4625	pathogenesis
IVG45_RS14725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IVG45_RS14735	COG1116	anion transmembrane transporter activity
IVG45_RS14740	COG1739	Uncharacterized protein family UPF0029
IVG45_RS14765	COG1132	(ABC) transporter
IVG45_RS14770	COG0463	Glycosyl transferase, family 2
IVG45_RS14775	COG0859	PFAM glycosyl transferase family 9
IVG45_RS14780	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS14785	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS14805	COG0835	chemotaxis
IVG45_RS14815	COG1192	Involved in chromosome partitioning
IVG45_RS14825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IVG45_RS14830	COG0784	Response regulator, receiver
IVG45_RS14830	COG0643	Histidine kinase
IVG45_RS14830	COG2198	Histidine kinase
IVG45_RS14835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IVG45_RS14865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IVG45_RS14870	COG1684	flagellar biosynthetic protein fliR
IVG45_RS14875	COG1987	bacterial-type flagellum assembly
IVG45_RS14905	COG0191	fructose-bisphosphate aldolase activity
IVG45_RS14910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IVG45_RS14920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IVG45_RS14930	COG1555	photosystem II stabilization
IVG45_RS14935	COG0500	methyltransferase
IVG45_RS14945	COG2854	intermembrane phospholipid transfer
IVG45_RS14960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IVG45_RS14980	COG0339	signal peptide processing
IVG45_RS14995	COG0196	riboflavin kinase activity
IVG45_RS15005	COG0604	alcohol dehydrogenase
IVG45_RS15005	COG3321	synthase
IVG45_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
IVG45_RS15010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IVG45_RS15020	COG0535	radical SAM domain protein
IVG45_RS15045	COG3391	amine dehydrogenase activity
IVG45_RS15065	COG2863	cytochrome
IVG45_RS15070	COG2010	Cytochrome c
IVG45_RS15080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IVG45_RS15085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IVG45_RS15090	COG1943	Transposase
IVG45_RS15095	COG0563	adenylate kinase activity
IVG45_RS15100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IVG45_RS15105	COG0066	3-isopropylmalate dehydratase activity
IVG45_RS15110	COG0473	3-isopropylmalate dehydrogenase activity
IVG45_RS15115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IVG45_RS15125	COG0457	Tetratricopeptide repeat
IVG45_RS15125	COG0515	serine threonine protein kinase
IVG45_RS15150	COG3108	Peptidase M15
IVG45_RS15165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IVG45_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
IVG45_RS15180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IVG45_RS15195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IVG45_RS15265	COG0617	tRNA 3'-terminal CCA addition
IVG45_RS15275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IVG45_RS15280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IVG45_RS15285	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IVG45_RS15290	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IVG45_RS15295	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IVG45_RS15335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IVG45_RS15340	COG0019	diaminopimelate decarboxylase activity
IVG45_RS15345	COG3594	Acyltransferase
IVG45_RS15365	COG1530	ribonuclease E activity
IVG45_RS15370	COG0424	maF-like protein
IVG45_RS15375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IVG45_RS15380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IVG45_RS15385	COG3002	Belongs to the UPF0753 family
IVG45_RS15405	COG0288	reversible hydration of carbon dioxide
IVG45_RS15410	COG0659	secondary active sulfate transmembrane transporter activity
IVG45_RS15420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IVG45_RS15425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IVG45_RS15430	COG2815	serine threonine protein kinase
IVG45_RS15430	COG0515	serine threonine protein kinase
IVG45_RS15435	COG1561	YicC-like family, N-terminal region
IVG45_RS15470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IVG45_RS15475	COG0194	GDP metabolic process
IVG45_RS15480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IVG45_RS15485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IVG45_RS15505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IVG45_RS15510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IVG45_RS15555	COG2226	methyltransferase
IVG45_RS15570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IVG45_RS15580	COG2967	ApaG domain
IVG45_RS15585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IVG45_RS15620	COG2304	oxidoreductase activity
IVG45_RS15635	COG5001	Diguanylate cyclase
IVG45_RS15635	COG4251	negative regulation of phosphorylation
IVG45_RS15635	COG3706	GGDEF domain
IVG45_RS15635	COG2203	Gaf domain
IVG45_RS15645	COG3045	CreA protein
IVG45_RS15650	COG0714	Associated with various cellular activities
IVG45_RS15665	COG0540	Belongs to the ATCase OTCase family
IVG45_RS15670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IVG45_RS15675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IVG45_RS15680	COG1678	Uncharacterized ACR, COG1678
IVG45_RS15690	COG0189	ligase activity
IVG45_RS15695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IVG45_RS15700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IVG45_RS15705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IVG45_RS15710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IVG45_RS15715	COG0210	DNA helicase
IVG45_RS15720	COG0033	Phosphoglucomutase
IVG45_RS15735	COG1376	ErfK ybiS ycfS ynhG family protein
IVG45_RS15740	COG2974	May be involved in recombination
IVG45_RS15750	COG3028	Belongs to the UPF0307 family
IVG45_RS15760	COG0517	IMP dehydrogenase activity
IVG45_RS15770	COG0235	Class ii aldolase
IVG45_RS15775	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IVG45_RS15780	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IVG45_RS15785	COG0189	ligase activity
IVG45_RS15805	COG3158	transport of potassium into the cell
IVG45_RS15820	COG3350	monooxygenase activity
IVG45_RS15845	COG0543	2 iron, 2 sulfur cluster binding
IVG45_RS15845	COG0633	Ferredoxin
IVG45_RS15855	COG0459	protein refolding
IVG45_RS15860	COG3284	Transcriptional regulator
IVG45_RS15865	COG0625	glutathione transferase activity
IVG45_RS15870	COG1309	transcriptional regulator
IVG45_RS15875	COG0432	Pfam Uncharacterised protein family UPF0047
IVG45_RS15885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IVG45_RS15890	COG1943	Transposase
IVG45_RS15895	COG0134	indole-3-glycerol-phosphate synthase activity
IVG45_RS15900	COG0631	protein serine/threonine phosphatase activity
IVG45_RS15905	COG1716	ATPase activity
IVG45_RS15925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IVG45_RS15930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IVG45_RS15935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IVG45_RS15940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IVG45_RS15945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IVG45_RS15950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IVG45_RS15955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IVG45_RS15960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IVG45_RS15970	COG0356	it plays a direct role in the translocation of protons across the membrane
IVG45_RS15980	COG1475	DNA binding
IVG45_RS15985	COG1192	Involved in chromosome partitioning
IVG45_RS15990	COG0357	Ribosomal RNA small subunit methyltransferase G
IVG45_RS15995	COG0445	tRNA wobble uridine modification
IVG45_RS16005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IVG45_RS16005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IVG45_RS16010	COG1067	ATP-dependent peptidase activity
IVG45_RS16040	COG3706	GGDEF domain
IVG45_RS16050	COG2862	Uncharacterized protein family, UPF0114
IVG45_RS16055	COG1410	methionine synthase
IVG45_RS16055	COG0646	methionine synthase
IVG45_RS16085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IVG45_RS16090	COG0751	glycine-tRNA ligase activity
IVG45_RS16095	COG0752	glycyl-tRNA synthetase alpha subunit
IVG45_RS16100	COG0429	hydrolase of the alpha beta-hydrolase fold
IVG45_RS16115	COG0501	Belongs to the peptidase M48B family
IVG45_RS16125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IVG45_RS16130	COG1166	arginine decarboxylase activity
IVG45_RS16140	COG2084	Dehydrogenase
IVG45_RS16155	COG0531	amino acid
IVG45_RS16165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IVG45_RS16180	COG1674	ftsk spoiiie
IVG45_RS16200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IVG45_RS16200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IVG45_RS16205	COG1393	Belongs to the ArsC family
IVG45_RS16215	COG1760	l-serine dehydratase
IVG45_RS16245	COG0018	arginyl-trna synthetase
IVG45_RS16255	COG0805	protein transport
IVG45_RS16260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IVG45_RS16265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IVG45_RS16270	COG0140	phosphoribosyl-ATP diphosphatase activity
IVG45_RS16280	COG0583	DNA-binding transcription factor activity
IVG45_RS16295	COG1217	gtp-binding protein TYPA
IVG45_RS16305	COG0730	response to heat
IVG45_RS16315	COG1322	Protein conserved in bacteria
IVG45_RS16325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IVG45_RS16340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IVG45_RS16345	COG0592	DNA-directed DNA polymerase activity
IVG45_RS16350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IVG45_RS16355	COG0187	DNA topoisomerase II activity
IVG45_RS16365	COG2361	Protein of unknown function DUF86
IVG45_RS16380	COG0732	type I restriction modification DNA specificity domain
IVG45_RS16385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IVG45_RS16405	COG4783	chaperone-mediated protein folding
IVG45_RS16425	COG2169	Transcriptional regulator
IVG45_RS16425	COG1917	Cupin 2, conserved barrel domain protein
IVG45_RS16435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IVG45_RS16440	COG0037	tRNA processing
IVG45_RS16440	COG0590	tRNA wobble adenosine to inosine editing
IVG45_RS16445	COG1301	dicarboxylic acid transport
IVG45_RS16495	COG2193	ferroxidase activity
IVG45_RS16500	COG1032	radical SAM domain protein
IVG45_RS16505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IVG45_RS16515	COG3220	belongs to the UPF0276 family
IVG45_RS16540	COG2198	Histidine kinase
IVG45_RS16540	COG0643	Histidine kinase
IVG45_RS16545	COG0840	transmembrane signaling receptor activity
IVG45_RS16550	COG0835	chemotaxis
IVG45_RS16570	COG0840	transmembrane signaling receptor activity
IVG45_RS16575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IVG45_RS16585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IVG45_RS16590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IVG45_RS16600	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IVG45_RS16605	COG1765	OsmC-like protein
IVG45_RS16630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IVG45_RS16635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IVG45_RS16640	COG0508	dehydrogenase complex catalyzes the overall conversion of
IVG45_RS16665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IVG45_RS16670	COG0484	heat shock protein binding
IVG45_RS16675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IVG45_RS16685	COG2954	triphosphatase activity
IVG45_RS16695	COG5001	Diguanylate cyclase
IVG45_RS16715	COG1492	cobalamin metabolic process
IVG45_RS16720	COG0778	Nitroreductase
IVG45_RS16725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IVG45_RS16735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IVG45_RS16745	COG0589	response to stress
IVG45_RS16755	COG0488	(ABC) transporter
IVG45_RS16815	COG3259	Nickel-dependent hydrogenase
IVG45_RS16820	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
IVG45_RS16825	COG3383	formate dehydrogenase (NAD+) activity
IVG45_RS16830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IVG45_RS16840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IVG45_RS16845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IVG45_RS16855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IVG45_RS16860	COG1181	Belongs to the D-alanine--D-alanine ligase family
IVG45_RS16865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IVG45_RS16870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IVG45_RS16875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IVG45_RS16880	COG0772	Belongs to the SEDS family
IVG45_RS16885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IVG45_RS16890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IVG45_RS16895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IVG45_RS16910	COG3116	cell division
IVG45_RS16920	COG2001	Belongs to the MraZ family
IVG45_RS16925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IVG45_RS16930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IVG45_RS16940	COG0640	Transcriptional regulator
IVG45_RS16950	COG4942	peptidase
IVG45_RS16955	COG0793	Belongs to the peptidase S41A family
IVG45_RS16990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IVG45_RS16995	COG2211	Major facilitator Superfamily
IVG45_RS17000	COG0254	rRNA binding
IVG45_RS17100	COG0500	methyltransferase
IVG45_RS17115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IVG45_RS17145	COG0210	DNA helicase
IVG45_RS17200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IVG45_RS17220	COG2135	peptidase activity
IVG45_RS17280	COG0714	Associated with various cellular activities
IVG45_RS17310	COG0330	HflC and HflK could
IVG45_RS17325	COG2856	Zn peptidase
IVG45_RS17340	COG0642	Histidine kinase
IVG45_RS17350	COG2372	response to copper ion
IVG45_RS17350	COG1276	copper resistance
IVG45_RS17465	COG0372	Belongs to the citrate synthase family
IVG45_RS17490	COG0315	cyclic pyranopterin monophosphate synthase activity
IVG45_RS17495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IVG45_RS17500	COG0314	molybdopterin synthase activity
IVG45_RS17505	COG2205	protein histidine kinase activity
IVG45_RS17505	COG2198	Histidine kinase
IVG45_RS17505	COG0784	Response regulator, receiver
IVG45_RS17510	COG2201	protein-glutamate methylesterase activity
IVG45_RS17520	COG3290	protein histidine kinase activity
IVG45_RS17520	COG0840	transmembrane signaling receptor activity
IVG45_RS17525	COG0835	chemotaxis
IVG45_RS17530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IVG45_RS17535	COG3437	response regulator, receiver
IVG45_RS17545	COG4178	(ABC) transporter
IVG45_RS17565	COG1011	Hydrolase
IVG45_RS17570	COG0494	nUDIX hydrolase
IVG45_RS17575	COG3023	N-Acetylmuramoyl-L-alanine amidase
IVG45_RS17590	COG0450	alkyl hydroperoxide reductase
IVG45_RS17650	COG2963	transposase activity
IVG45_RS17705	COG2171	N-acyltransferase activity
IVG45_RS17715	COG0501	Belongs to the peptidase M48B family
IVG45_RS17730	COG1294	oxidase, subunit
IVG45_RS17755	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
IVG45_RS17760	COG1229	Formylmethanofuran dehydrogenase subunit A
IVG45_RS17770	COG2154	pterin-4-alpha-carbinolamine dehydratase
IVG45_RS17775	COG2969	positive regulation of protein catabolic process
IVG45_RS17785	COG2857	Cytochrome c1
IVG45_RS17790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IVG45_RS17795	COG0723	plastoquinol--plastocyanin reductase activity
IVG45_RS17800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IVG45_RS17805	COG1115	amino acid carrier protein
IVG45_RS17825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IVG45_RS17830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IVG45_RS17835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IVG45_RS17845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IVG45_RS17850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IVG45_RS17855	COG1127	ABC transporter
IVG45_RS17865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IVG45_RS17875	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IVG45_RS17880	COG1137	ATPase activity
IVG45_RS17885	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IVG45_RS17895	COG1660	Displays ATPase and GTPase activities
IVG45_RS17900	COG2239	Acts as a magnesium transporter
IVG45_RS17905	COG0850	regulation of cytokinetic process
IVG45_RS17910	COG2894	cell division
IVG45_RS17915	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IVG45_RS17930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IVG45_RS17940	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IVG45_RS17945	COG0747	negative chemotaxis
IVG45_RS17960	COG0601	transmembrane transport
IVG45_RS17965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IVG45_RS17970	COG4172	Belongs to the ABC transporter superfamily
IVG45_RS17980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IVG45_RS17985	COG2137	regulation of response to DNA damage stimulus
IVG45_RS17995	COG3744	PilT protein domain protein
IVG45_RS18000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IVG45_RS18050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IVG45_RS18065	COG1136	(ABC) transporter
IVG45_RS18065	COG0577	efflux transmembrane transporter activity
IVG45_RS18075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IVG45_RS18080	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IVG45_RS18110	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS18135	COG0110	maltose O-acetyltransferase activity
IVG45_RS18140	COG0463	Glycosyl transferase, family 2
IVG45_RS18165	COG3609	addiction module antidote protein, CC2985 family
IVG45_RS18180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IVG45_RS18185	COG0284	orotidine-5'-phosphate decarboxylase activity
IVG45_RS18190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IVG45_RS18235	COG2963	transposase activity
IVG45_RS18240	COG2801	Transposase and inactivated derivatives
IVG45_RS18255	COG3328	transposase activity
IVG45_RS18265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IVG45_RS18270	COG0107	imidazoleglycerol-phosphate synthase activity
IVG45_RS18275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IVG45_RS18280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IVG45_RS18285	COG0131	Imidazoleglycerol-phosphate dehydratase
IVG45_RS18290	COG0308	aminopeptidase N
IVG45_RS18300	COG2363	Small membrane protein
IVG45_RS18305	COG0521	Mo-molybdopterin cofactor biosynthetic process
IVG45_RS18315	COG0628	permease
IVG45_RS18330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IVG45_RS18335	COG2104	thiamine diphosphate biosynthetic process
IVG45_RS18335	COG2022	thiamine diphosphate biosynthetic process
IVG45_RS18355	COG0840	transmembrane signaling receptor activity
IVG45_RS18370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IVG45_RS18375	COG0594	ribonuclease P activity
IVG45_RS18385	COG0706	membrane insertase activity
IVG45_RS18390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IVG45_RS18395	COG0175	sulfate reduction
IVG45_RS18405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IVG45_RS18410	COG1194	a g-specific adenine glycosylase
IVG45_RS18430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IVG45_RS18430	COG0519	Catalyzes the synthesis of GMP from XMP
IVG45_RS18450	COG3100	YcgL domain-containing protein
IVG45_RS18465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IVG45_RS18470	COG0791	NLP P60 protein
IVG45_RS18495	COG0109	protoheme IX farnesyltransferase activity
IVG45_RS18500	COG0612	Peptidase, M16
IVG45_RS18505	COG0612	Peptidase, M16
IVG45_RS18510	COG0742	ribosomal rna small subunit methyltransferase
IVG45_RS18515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IVG45_RS18520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IVG45_RS18530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IVG45_RS18555	COG0181	hydroxymethylbilane synthase activity
IVG45_RS18565	COG1254	Belongs to the acylphosphatase family
IVG45_RS18570	COG0116	Belongs to the methyltransferase superfamily
IVG45_RS18570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IVG45_RS18585	COG4251	negative regulation of phosphorylation
IVG45_RS18590	COG0784	Response regulator, receiver
IVG45_RS18600	COG0009	L-threonylcarbamoyladenylate synthase
IVG45_RS18625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IVG45_RS18625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IVG45_RS18635	COG1360	Flagellar Motor Protein
IVG45_RS18655	COG1968	undecaprenyl-diphosphatase activity
IVG45_RS18690	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IVG45_RS18700	COG4206	TonB-dependent receptor
IVG45_RS18705	COG2308	Evidence 4 Homologs of previously reported genes of
IVG45_RS18735	COG1215	transferase activity, transferring glycosyl groups
IVG45_RS18770	COG1846	Transcriptional regulator
IVG45_RS18805	COG2801	Transposase and inactivated derivatives
IVG45_RS18880	COG3275	phosphorelay sensor kinase activity
IVG45_RS18885	COG3275	phosphorelay sensor kinase activity
IVG45_RS18890	COG3279	Response regulator of the LytR AlgR family
IVG45_RS18900	COG3328	transposase activity
IVG45_RS18920	COG2963	transposase activity
IVG45_RS19005	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IVG45_RS19045	COG2003	Belongs to the UPF0758 family
IVG45_RS19055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IVG45_RS19090	COG4974	Belongs to the 'phage' integrase family
IVG45_RS19145	COG2135	peptidase activity
IVG45_RS19155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IVG45_RS19205	COG0582	viral genome integration into host DNA
IVG45_RS19215	COG2801	Transposase and inactivated derivatives
IVG45_RS19230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IVG45_RS19260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IVG45_RS19270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IVG45_RS19290	COG1943	Transposase
IVG45_RS19305	COG1960	acyl-CoA dehydrogenase activity
IVG45_RS19330	COG4771	TonB-dependent receptor
IVG45_RS19340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IVG45_RS19345	COG0581	inorganic phosphate transmembrane transporter activity
IVG45_RS19365	COG0252	asparaginase activity
IVG45_RS19375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IVG45_RS19380	COG0792	nuclease activity
IVG45_RS19385	COG3107	peptidoglycan biosynthetic process
IVG45_RS19390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IVG45_RS19395	COG1858	cytochrome C peroxidase
IVG45_RS19425	COG0166	Belongs to the GPI family
IVG45_RS19450	COG0525	valine-tRNA ligase activity
IVG45_RS19475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IVG45_RS19480	COG0237	dephospho-CoA kinase activity
IVG45_RS19485	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IVG45_RS19490	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IVG45_RS19495	COG0494	nUDIX hydrolase
IVG45_RS19500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IVG45_RS19510	COG0482	sulfurtransferase activity
IVG45_RS19535	COG1652	LysM domain
IVG45_RS19540	COG0758	DNA mediated transformation
IVG45_RS19545	COG2922	Belongs to the Smg family
IVG45_RS19565	COG0544	peptidyl-prolyl cis-trans isomerase activity
IVG45_RS19570	COG0740	serine-type endopeptidase activity
IVG45_RS19575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IVG45_RS19580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IVG45_RS19585	COG0776	regulation of translation
IVG45_RS19600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IVG45_RS19625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IVG45_RS19630	COG0778	Nitroreductase
IVG45_RS19645	COG5002	protein histidine kinase activity
IVG45_RS19645	COG5001	Diguanylate cyclase
IVG45_RS19650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IVG45_RS19655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IVG45_RS19670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IVG45_RS19675	COG4221	oxidoreductase activity
IVG45_RS19685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IVG45_RS19690	COG0058	SHG alpha-glucan phosphorylase activity
IVG45_RS19695	COG0653	protein targeting
IVG45_RS19710	COG3391	amine dehydrogenase activity
IVG45_RS19720	COG1309	transcriptional regulator
IVG45_RS19730	COG0717	Belongs to the dCTP deaminase family
IVG45_RS19740	COG0837	glucose binding
IVG45_RS19750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IVG45_RS19750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IVG45_RS19765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IVG45_RS19770	COG0045	succinate-CoA ligase (ADP-forming) activity
IVG45_RS19790	COG5002	protein histidine kinase activity
IVG45_RS19790	COG5001	Diguanylate cyclase
IVG45_RS19815	COG2204	response regulator
IVG45_RS19820	COG3852	Histidine kinase
IVG45_RS19825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IVG45_RS19835	COG2890	protein-(glutamine-N5) methyltransferase activity
IVG45_RS19840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IVG45_RS19845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IVG45_RS19855	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IVG45_RS19860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IVG45_RS19870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IVG45_RS19875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IVG45_RS19880	COG0193	aminoacyl-tRNA hydrolase activity
IVG45_RS19900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IVG45_RS19910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IVG45_RS19920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IVG45_RS19925	COG0081	regulation of translation
IVG45_RS19930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IVG45_RS19935	COG0222	ribosome binding
IVG45_RS19940	COG0085	RNA polymerase activity
IVG45_RS19945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IVG45_RS19955	COG0049	tRNA binding
IVG45_RS19960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IVG45_RS19965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IVG45_RS19970	COG0051	transcription antitermination factor activity, RNA binding
IVG45_RS19975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IVG45_RS19980	COG0088	Forms part of the polypeptide exit tunnel
IVG45_RS19985	COG0089	rRNA binding
IVG45_RS19990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IVG45_RS19995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IVG45_RS20000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IVG45_RS20005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IVG45_RS20010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IVG45_RS20015	COG0255	Belongs to the universal ribosomal protein uL29 family
IVG45_RS20020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IVG45_RS20025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IVG45_RS20030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IVG45_RS20035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IVG45_RS20040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IVG45_RS20045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IVG45_RS20050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IVG45_RS20055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IVG45_RS20060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IVG45_RS20065	COG1841	ribosomal large subunit assembly
IVG45_RS20075	COG0201	protein transport
IVG45_RS20080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IVG45_RS20085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IVG45_RS20090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IVG45_RS20095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IVG45_RS20100	COG0202	RNA polymerase activity
IVG45_RS20105	COG0203	ribosomal protein L17
IVG45_RS20130	COG0473	3-isopropylmalate dehydrogenase activity
IVG45_RS20135	COG0535	radical SAM domain protein
IVG45_RS20145	COG4636	protein conserved in cyanobacteria
IVG45_RS20155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IVG45_RS20165	COG0730	response to heat
IVG45_RS20170	COG0617	tRNA 3'-terminal CCA addition
IVG45_RS20180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IVG45_RS20190	COG0312	modulator of DNA gyrase
IVG45_RS20195	COG0312	modulator of DNA gyrase
IVG45_RS20200	COG2770	Histidine kinase
IVG45_RS20200	COG3437	response regulator, receiver
IVG45_RS20205	COG0167	dihydroorotate dehydrogenase activity
IVG45_RS20225	COG0163	prenyltransferase activity
IVG45_RS20235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IVG45_RS20270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IVG45_RS20275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IVG45_RS20280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IVG45_RS20285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IVG45_RS20290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IVG45_RS20295	COG1610	YqeY-like protein
IVG45_RS20300	COG0358	DNA primase activity
IVG45_RS20315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IVG45_RS20320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IVG45_RS20325	COG3240	lipase activity
IVG45_RS20335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IVG45_RS20365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IVG45_RS20370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IVG45_RS20375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IVG45_RS20405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IVG45_RS20410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IVG45_RS20420	COG2089	acid synthase
IVG45_RS20430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IVG45_RS20435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IVG45_RS20440	COG1334	flagellar protein FlaG
IVG45_RS20475	COG4137	Cytochrome C assembly protein
IVG45_RS20480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IVG45_RS20485	COG0228	four-way junction DNA binding
IVG45_RS20490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IVG45_RS20500	COG0335	large ribosomal subunit rRNA binding
IVG45_RS20515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IVG45_RS20530	COG5002	protein histidine kinase activity
IVG45_RS20530	COG5001	Diguanylate cyclase
IVG45_RS20540	COG1362	aminopeptidase activity
IVG45_RS20545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IVG45_RS20550	COG0446	pyridine nucleotide-disulphide oxidoreductase
IVG45_RS20560	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IVG45_RS20570	COG0215	cysteine-tRNA ligase activity
IVG45_RS20575	COG3404	Formiminotransferase-cyclodeaminase
IVG45_RS20585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IVG45_RS20590	COG1160	GTP binding
IVG45_RS20605	COG0124	histidyl-tRNA synthetase
IVG45_RS20615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IVG45_RS20620	COG0105	UTP biosynthetic process
IVG45_RS20625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IVG45_RS20630	COG1862	Preprotein translocase
IVG45_RS20635	COG0688	phosphatidylethanolamine metabolic process
IVG45_RS20645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IVG45_RS20660	COG1136	(ABC) transporter
IVG45_RS20665	COG0577	efflux transmembrane transporter activity
IVG45_RS20700	COG4251	negative regulation of phosphorylation
IVG45_RS20705	COG5001	Diguanylate cyclase
IVG45_RS20710	COG0784	Response regulator, receiver
IVG45_RS20720	COG0598	Magnesium transport protein CorA
IVG45_RS20760	COG4251	negative regulation of phosphorylation
IVG45_RS20760	COG2203	Gaf domain
IVG45_RS20760	COG3706	GGDEF domain
IVG45_RS20760	COG5001	Diguanylate cyclase
IVG45_RS20795	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IVG45_RS20830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IVG45_RS20835	COG1993	acr, cog1993
IVG45_RS20845	COG0129	dihydroxy-acid dehydratase activity
IVG45_RS20870	COG2226	methyltransferase
IVG45_RS20875	COG0798	PFAM Bile acid sodium symporter
IVG45_RS20900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IVG45_RS20915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IVG45_RS20970	COG2217	Heavy metal translocating P-type atpase
IVG45_RS20985	COG1132	(ABC) transporter
IVG45_RS21020	COG0174	glutamine synthetase
IVG45_RS21030	COG0347	Belongs to the P(II) protein family
IVG45_RS21035	COG0004	ammonium transporteR
IVG45_RS21045	COG0004	ammonium transporteR
IVG45_RS21050	COG0483	inositol monophosphate 1-phosphatase activity
IVG45_RS21055	COG3707	response regulator
IVG45_RS21060	COG2223	nitrite transmembrane transporter activity
IVG45_RS21065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IVG45_RS21065	COG2146	nitrite reductase [NAD(P)H] activity
IVG45_RS21070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IVG45_RS21070	COG2146	nitrite reductase [NAD(P)H] activity
IVG45_RS21075	COG0384	phenazine biosynthesis protein PhzF
IVG45_RS21080	COG3852	Histidine kinase
IVG45_RS21085	COG2204	response regulator
IVG45_RS21105	COG0584	glycerophosphoryl diester phosphodiesterase
IVG45_RS21130	COG2409	Drug exporters of the RND superfamily
IVG45_RS21135	COG0589	response to stress
IVG45_RS21140	COG1295	ribonuclease BN
IVG45_RS21145	COG0513	Belongs to the DEAD box helicase family
IVG45_RS21190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IVG45_RS21235	COG0741	lytic transglycosylase activity
IVG45_RS21240	COG2204	response regulator
IVG45_RS21245	COG4191	Histidine kinase
IVG45_RS21275	COG0489	protein tyrosine kinase activity
IVG45_RS21295	COG0726	polysaccharide deacetylase
IVG45_RS21310	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS21315	COG0367	asparagine synthase
IVG45_RS21335	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS21340	COG0297	glycogen (starch) synthase activity
IVG45_RS21355	COG1981	membrane
IVG45_RS21385	COG0840	transmembrane signaling receptor activity
IVG45_RS21420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IVG45_RS21420	COG4651	solute:proton antiporter activity
IVG45_RS21425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IVG45_RS21435	COG0697	spore germination
IVG45_RS21440	COG0497	DNA recombination
IVG45_RS21445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IVG45_RS21450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IVG45_RS21450	COG4191	Histidine kinase
IVG45_RS21455	COG0784	Response regulator, receiver
IVG45_RS21455	COG3437	response regulator, receiver
IVG45_RS21475	COG2226	methyltransferase
IVG45_RS21620	COG2204	response regulator
IVG45_RS21625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IVG45_RS21630	COG0730	response to heat
IVG45_RS21640	COG2132	Multicopper oxidase
IVG45_RS21665	COG1294	oxidase, subunit
IVG45_RS21675	COG0430	RNA-3'-phosphate cyclase activity
IVG45_RS21680	COG1690	Belongs to the RtcB family
IVG45_RS21685	COG4650	regulator
IVG45_RS21690	COG0281	malic enzyme
IVG45_RS21695	COG1404	Belongs to the peptidase S8 family
IVG45_RS21790	COG2878	Part of a membrane complex involved in electron transport
IVG45_RS21795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IVG45_RS21795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IVG45_RS21810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IVG45_RS21820	COG0142	geranyltranstransferase activity
IVG45_RS21825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IVG45_RS21830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IVG45_RS21835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IVG45_RS21840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IVG45_RS21850	COG0489	protein tyrosine kinase activity
IVG45_RS21870	COG1376	ErfK ybiS ycfS ynhG family protein
IVG45_RS21880	COG0268	Binds directly to 16S ribosomal RNA
IVG45_RS21885	COG0728	peptidoglycan biosynthetic process
IVG45_RS21905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IVG45_RS21915	COG0756	dUTP diphosphatase activity
IVG45_RS21920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IVG45_RS21925	COG2003	Belongs to the UPF0758 family
IVG45_RS21940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IVG45_RS21945	COG1393	Belongs to the ArsC family
IVG45_RS21955	COG0438	transferase activity, transferring glycosyl groups
IVG45_RS21990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IVG45_RS22005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IVG45_RS22015	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
IVG45_RS22020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IVG45_RS22095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IVG45_RS22100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IVG45_RS22105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IVG45_RS22110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IVG45_RS22115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IVG45_RS22120	COG0470	DNA polymerase III
IVG45_RS22130	COG0084	hydrolase, TatD family'
IVG45_RS22135	COG2813	Specifically methylates the guanine in position
IVG45_RS22140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IVG45_RS22145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IVG45_RS22165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IVG45_RS22170	COG1657	PFAM Prenyltransferase squalene oxidase
IVG45_RS22180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IVG45_RS22185	COG2854	intermembrane phospholipid transfer
IVG45_RS22190	COG2853	Lipoprotein
IVG45_RS22195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IVG45_RS22200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IVG45_RS22205	COG0142	geranyltranstransferase activity
IVG45_RS22210	COG1722	exodeoxyribonuclease VII activity
IVG45_RS22235	COG2815	serine threonine protein kinase
IVG45_RS22235	COG0515	serine threonine protein kinase
IVG45_RS22260	COG1360	Flagellar Motor Protein
IVG45_RS22300	COG0412	Dienelactone hydrolase
IVG45_RS22310	COG4181	ATPase activity
IVG45_RS22360	COG0456	acetyltransferase
IVG45_RS22375	COG2226	methyltransferase
IVG45_RS22405	COG2963	transposase activity
IVG45_RS22410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IVG45_RS22415	COG4208	sulfate ABC transporter
IVG45_RS22420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IVG45_RS22425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IVG45_RS22450	COG0702	epimerase
IVG45_RS22470	COG1420	regulation of RNA biosynthetic process
IVG45_RS22475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ