locus-tag	class	description
MCHL_RS00010	COG0268	Binds directly to 16S ribosomal RNA
MCHL_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MCHL_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCHL_RS00040	COG0514	ATP-dependent DNA helicase (RecQ)
MCHL_RS00055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCHL_RS00065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCHL_RS00080	COG0492	ferredoxin-NADP+ reductase activity
MCHL_RS00100	COG4191	Histidine kinase
MCHL_RS00100	COG0784	Response regulator, receiver
MCHL_RS00115	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS00120	COG1802	Transcriptional regulator
MCHL_RS00135	COG3052	prosthetic group binding
MCHL_RS00155	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
MCHL_RS00175	COG2165	general secretion pathway protein
MCHL_RS00180	COG1999	signal sequence binding
MCHL_RS00195	COG1484	DNA-dependent DNA replication
MCHL_RS00210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MCHL_RS00215	COG0784	Response regulator, receiver
MCHL_RS00215	COG4191	Histidine kinase
MCHL_RS00290	COG2226	methyltransferase
MCHL_RS00345	COG3750	Belongs to the UPF0335 family
MCHL_RS00365	COG4957	zinc ion binding
MCHL_RS00380	COG2267	carboxylic ester hydrolase activity
MCHL_RS00535	COG0135	phosphoribosylanthranilate isomerase activity
MCHL_RS00545	COG0776	regulation of translation
MCHL_RS00550	COG0616	signal peptide processing
MCHL_RS00560	COG0539	negative regulation of cytoplasmic translation
MCHL_RS00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCHL_RS00580	COG1741	Belongs to the pirin family
MCHL_RS00585	COG0475	glutathione-regulated potassium exporter activity
MCHL_RS00585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCHL_RS00615	COG0488	(ABC) transporter
MCHL_RS00650	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS00655	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS00660	COG1216	Glycosyl transferase, family 2
MCHL_RS00675	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS00720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCHL_RS00725	COG0277	FAD linked oxidase domain protein
MCHL_RS00735	COG0437	4 iron, 4 sulfur cluster binding
MCHL_RS00775	COG1845	cytochrome c oxidase, subunit III
MCHL_RS00805	COG0753	catalase activity
MCHL_RS00835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MCHL_RS00845	COG2205	protein histidine kinase activity
MCHL_RS00880	COG1260	myo-inositol-1-phosphate synthase
MCHL_RS00910	COG1032	radical SAM domain protein
MCHL_RS00915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS00930	COG0612	Peptidase, M16
MCHL_RS00945	COG0010	Belongs to the arginase family
MCHL_RS00950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MCHL_RS00960	COG3712	iron ion homeostasis
MCHL_RS00965	COG1595	DNA-templated transcription, initiation
MCHL_RS00970	COG0628	permease
MCHL_RS00975	COG3920	Histidine kinase
MCHL_RS01010	COG0583	DNA-binding transcription factor activity
MCHL_RS01015	COG0667	Aldo Keto reductase
MCHL_RS01020	COG5001	Diguanylate cyclase
MCHL_RS01105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MCHL_RS01125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MCHL_RS01125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MCHL_RS01250	COG4957	zinc ion binding
MCHL_RS01260	COG4191	Histidine kinase
MCHL_RS01260	COG0784	Response regulator, receiver
MCHL_RS01290	COG0616	signal peptide processing
MCHL_RS01410	COG3300	MHYT domain
MCHL_RS01410	COG5001	Diguanylate cyclase
MCHL_RS01435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCHL_RS01440	COG1525	nuclease
MCHL_RS01455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MCHL_RS01460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MCHL_RS01465	COG0443	Heat shock 70 kDa protein
MCHL_RS01475	COG0546	phosphoglycolate phosphatase activity
MCHL_RS01485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MCHL_RS01500	COG1309	transcriptional regulator
MCHL_RS01505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MCHL_RS01515	COG3510	cephalosporin hydroxylase
MCHL_RS01520	COG0604	alcohol dehydrogenase
MCHL_RS01525	COG0753	catalase activity
MCHL_RS01530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCHL_RS01530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCHL_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS01545	COG0640	Transcriptional regulator
MCHL_RS01550	COG0180	Tryptophanyl-tRNA synthetase
MCHL_RS01555	COG0066	3-isopropylmalate dehydratase activity
MCHL_RS01560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MCHL_RS01565	COG1703	isobutyryl-CoA mutase activity
MCHL_RS01585	COG1388	LysM domain
MCHL_RS01585	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS01595	COG0420	3'-5' exonuclease activity
MCHL_RS01600	COG0419	ATPase involved in DNA repair
MCHL_RS01605	COG2223	nitrite transmembrane transporter activity
MCHL_RS01615	COG2226	methyltransferase
MCHL_RS01630	COG0494	nUDIX hydrolase
MCHL_RS01640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MCHL_RS01685	COG0210	DNA helicase
MCHL_RS01705	COG2140	Oxalate decarboxylase
MCHL_RS01710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MCHL_RS01730	COG0745	RESPONSE REGULATOR receiver
MCHL_RS01745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS01760	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MCHL_RS01765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MCHL_RS01770	COG0077	Prephenate dehydratase
MCHL_RS01770	COG1605	Chorismate mutase
MCHL_RS01785	COG4166	transmembrane transport
MCHL_RS01790	COG4166	transmembrane transport
MCHL_RS01795	COG4174	ABC transporter (Permease)
MCHL_RS01810	COG0463	Glycosyl transferase, family 2
MCHL_RS01835	COG3237	CsbD-like
MCHL_RS01845	COG3781	membrane
MCHL_RS01850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCHL_RS01855	COG2967	ApaG domain
MCHL_RS01870	COG2116	formate transmembrane transporter activity
MCHL_RS01875	COG1058	Belongs to the CinA family
MCHL_RS01875	COG1546	Belongs to the CinA family
MCHL_RS01900	COG0842	Transport permease protein
MCHL_RS01905	COG1131	(ABC) transporter
MCHL_RS01950	COG3383	formate dehydrogenase (NAD+) activity
MCHL_RS01950	COG0243	molybdopterin cofactor binding
MCHL_RS01955	COG0437	4 iron, 4 sulfur cluster binding
MCHL_RS02020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MCHL_RS02025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCHL_RS02035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MCHL_RS02050	COG1732	Glycine betaine
MCHL_RS02055	COG1174	glycine betaine transport
MCHL_RS02060	COG1174	glycine betaine transport
MCHL_RS02065	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS02105	COG0745	RESPONSE REGULATOR receiver
MCHL_RS02110	COG0196	riboflavin kinase activity
MCHL_RS02140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MCHL_RS02145	COG1338	Plays a role in the flagellum-specific transport system
MCHL_RS02150	COG2259	Doxx family
MCHL_RS02170	COG4957	zinc ion binding
MCHL_RS02185	COG2166	iron-sulfur cluster assembly
MCHL_RS02190	COG3920	Histidine kinase
MCHL_RS02215	COG0308	aminopeptidase N
MCHL_RS02220	COG2205	protein histidine kinase activity
MCHL_RS02220	COG2202	Pas domain
MCHL_RS02230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MCHL_RS02240	COG1324	tolerance protein
MCHL_RS02245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MCHL_RS02275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MCHL_RS02285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCHL_RS02290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCHL_RS02295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MCHL_RS02300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCHL_RS02310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCHL_RS02315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS02320	COG0842	Transport permease protein
MCHL_RS02320	COG1129	ABC transporter
MCHL_RS02325	COG0842	Transport permease protein
MCHL_RS02330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MCHL_RS02360	COG3920	Histidine kinase
MCHL_RS02380	COG1366	Belongs to the anti-sigma-factor antagonist family
MCHL_RS02385	COG1366	Belongs to the anti-sigma-factor antagonist family
MCHL_RS02405	COG4191	Histidine kinase
MCHL_RS02405	COG0784	Response regulator, receiver
MCHL_RS02415	COG4251	negative regulation of phosphorylation
MCHL_RS02415	COG3706	GGDEF domain
MCHL_RS02415	COG2203	Gaf domain
MCHL_RS02415	COG5001	Diguanylate cyclase
MCHL_RS02440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MCHL_RS02455	COG2203	Gaf domain
MCHL_RS02455	COG2200	EAL domain
MCHL_RS02455	COG2199	diguanylate cyclase activity
MCHL_RS02475	COG5001	Diguanylate cyclase
MCHL_RS02475	COG3300	MHYT domain
MCHL_RS02585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MCHL_RS02595	COG0348	domain, Protein
MCHL_RS02600	COG0437	4 iron, 4 sulfur cluster binding
MCHL_RS02610	COG1858	cytochrome C peroxidase
MCHL_RS02620	COG3794	PFAM blue (type 1) copper domain protein
MCHL_RS02630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCHL_RS02635	COG2259	Doxx family
MCHL_RS02640	COG3391	amine dehydrogenase activity
MCHL_RS02645	COG0785	Cytochrome C biogenesis protein
MCHL_RS02690	COG3842	ATPase activity
MCHL_RS02695	COG1840	ABC-type Fe3 transport system, periplasmic component
MCHL_RS02725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS02745	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MCHL_RS02755	COG4208	sulfate ABC transporter
MCHL_RS02760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MCHL_RS02800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCHL_RS02805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MCHL_RS02815	COG1216	Glycosyl transferase, family 2
MCHL_RS02815	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS02850	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MCHL_RS02860	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCHL_RS02865	COG0047	phosphoribosylformylglycinamidine synthase activity
MCHL_RS02870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCHL_RS02875	COG0483	inositol monophosphate 1-phosphatase activity
MCHL_RS02880	COG0352	thiamine-phosphate diphosphorylase activity
MCHL_RS02885	COG2022	thiamine diphosphate biosynthetic process
MCHL_RS02895	COG2022	thiamine diphosphate biosynthetic process
MCHL_RS02895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCHL_RS02920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MCHL_RS02925	COG0358	DNA primase activity
MCHL_RS02930	COG3386	PFAM SMP-30 Gluconolaconase
MCHL_RS02945	COG0505	Belongs to the CarA family
MCHL_RS02960	COG1815	bacterial-type flagellum-dependent cell motility
MCHL_RS02965	COG1558	bacterial-type flagellum-dependent cell motility
MCHL_RS02975	COG4786	Flagellar basal body rod
MCHL_RS02985	COG1706	bacterial-type flagellum-dependent cell motility
MCHL_RS02995	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MCHL_RS03005	COG1338	Plays a role in the flagellum-specific transport system
MCHL_RS03055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MCHL_RS03060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MCHL_RS03065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MCHL_RS03085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MCHL_RS03125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCHL_RS03135	COG0228	four-way junction DNA binding
MCHL_RS03160	COG0336	Belongs to the RNA methyltransferase TrmD family
MCHL_RS03165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MCHL_RS03170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCHL_RS03190	COG0534	Mate efflux family protein
MCHL_RS03195	COG1132	(ABC) transporter
MCHL_RS03200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MCHL_RS03205	COG0840	transmembrane signaling receptor activity
MCHL_RS03220	COG2268	Band 7 protein
MCHL_RS03225	COG4774	siderophore transport
MCHL_RS03230	COG0408	coproporphyrinogen oxidase activity
MCHL_RS03235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCHL_RS03240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCHL_RS03270	COG4786	Flagellar basal body rod
MCHL_RS03275	COG1157	protein secretion by the type III secretion system
MCHL_RS03280	COG1749	Flagellar hook protein flgE
MCHL_RS03300	COG5443	negative regulation of bacterial-type flagellum assembly
MCHL_RS03305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MCHL_RS03310	COG4794	Type iii secretion
MCHL_RS03315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MCHL_RS03345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCHL_RS03365	COG2205	protein histidine kinase activity
MCHL_RS03375	COG1294	oxidase, subunit
MCHL_RS03380	COG2271	Major facilitator Superfamily
MCHL_RS03385	COG2814	Major facilitator Superfamily
MCHL_RS03395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCHL_RS03405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MCHL_RS03430	COG0123	including yeast histone deacetylase and acetoin utilization protein
MCHL_RS03470	COG0519	Catalyzes the synthesis of GMP from XMP
MCHL_RS03470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCHL_RS03475	COG0667	Aldo Keto reductase
MCHL_RS03480	COG2207	Transcriptional regulator
MCHL_RS03520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCHL_RS03530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCHL_RS03565	COG0840	transmembrane signaling receptor activity
MCHL_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS03750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MCHL_RS03775	COG0745	RESPONSE REGULATOR receiver
MCHL_RS03785	COG0110	maltose O-acetyltransferase activity
MCHL_RS03790	COG0281	malic enzyme
MCHL_RS03790	COG0280	phosphate acetyltransferase
MCHL_RS03830	COG2080	2 iron, 2 sulfur cluster binding
MCHL_RS03835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MCHL_RS03840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCHL_RS03845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCHL_RS03855	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MCHL_RS03915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCHL_RS03915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCHL_RS03925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MCHL_RS03940	COG0791	NLP P60 protein
MCHL_RS03960	COG0714	Associated with various cellular activities
MCHL_RS03975	COG2304	oxidoreductase activity
MCHL_RS04015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCHL_RS04025	COG3920	Histidine kinase
MCHL_RS04025	COG2202	Pas domain
MCHL_RS04030	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS04045	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MCHL_RS04060	COG0693	protein deglycase activity
MCHL_RS04080	COG1278	Cold shock
MCHL_RS04100	COG2814	Major facilitator Superfamily
MCHL_RS04105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MCHL_RS04110	COG1127	ABC transporter
MCHL_RS04125	COG0483	inositol monophosphate 1-phosphatase activity
MCHL_RS04135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MCHL_RS04200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MCHL_RS04205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MCHL_RS04210	COG2205	protein histidine kinase activity
MCHL_RS04225	COG3920	Histidine kinase
MCHL_RS04230	COG0154	amidase activity
MCHL_RS04250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MCHL_RS04265	COG0277	FAD linked oxidase domain protein
MCHL_RS04275	COG1846	Transcriptional regulator
MCHL_RS04290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MCHL_RS04295	COG2983	Belongs to the UPF0260 family
MCHL_RS04320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MCHL_RS04325	COG2094	Belongs to the DNA glycosylase MPG family
MCHL_RS04330	COG0328	RNA-DNA hybrid ribonuclease activity
MCHL_RS04350	COG0189	ligase activity
MCHL_RS04355	COG0025	NhaP-type Na H and K H
MCHL_RS04360	COG3023	N-Acetylmuramoyl-L-alanine amidase
MCHL_RS04365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MCHL_RS04375	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MCHL_RS04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCHL_RS04390	COG5001	Diguanylate cyclase
MCHL_RS04395	COG0745	RESPONSE REGULATOR receiver
MCHL_RS04405	COG1749	Flagellar hook protein flgE
MCHL_RS04425	COG2890	protein-(glutamine-N5) methyltransferase activity
MCHL_RS04430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MCHL_RS04440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCHL_RS04445	COG0527	aspartate kinase activity
MCHL_RS04450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCHL_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS04460	COG0604	alcohol dehydrogenase
MCHL_RS04460	COG3321	synthase
MCHL_RS04465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MCHL_RS04475	COG0632	four-way junction helicase activity
MCHL_RS04485	COG0784	Response regulator, receiver
MCHL_RS04495	COG1959	2 iron, 2 sulfur cluster binding
MCHL_RS04500	COG1017	nitric oxide dioxygenase activity
MCHL_RS04500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCHL_RS04515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MCHL_RS04535	COG0583	DNA-binding transcription factor activity
MCHL_RS04565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS04595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCHL_RS04610	COG1982	Orn Lys Arg decarboxylase major
MCHL_RS04620	COG0521	Mo-molybdopterin cofactor biosynthetic process
MCHL_RS04625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MCHL_RS04650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MCHL_RS04655	COG5001	Diguanylate cyclase
MCHL_RS04655	COG3300	MHYT domain
MCHL_RS04670	COG0564	pseudouridine synthase activity
MCHL_RS04695	COG4774	siderophore transport
MCHL_RS04715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCHL_RS04755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCHL_RS04855	COG1937	Protein conserved in bacteria
MCHL_RS04905	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCHL_RS04935	COG1595	DNA-templated transcription, initiation
MCHL_RS04965	COG2132	Multicopper oxidase
MCHL_RS05020	COG0431	NADPH-dependent FMN reductase
MCHL_RS05035	COG1393	Belongs to the ArsC family
MCHL_RS05040	COG0798	PFAM Bile acid sodium symporter
MCHL_RS05075	COG3177	Filamentation induced by cAMP protein fic
MCHL_RS05230	COG3034	peptidoglycan biosynthetic process
MCHL_RS05235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MCHL_RS05245	COG0789	Transcriptional regulator
MCHL_RS05310	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCHL_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS05450	COG2080	2 iron, 2 sulfur cluster binding
MCHL_RS05455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MCHL_RS05460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCHL_RS05475	COG1162	GTPase activity
MCHL_RS05510	COG0739	heme binding
MCHL_RS05520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCHL_RS05555	COG2226	methyltransferase
MCHL_RS05595	COG1797	cobyrinic acid a,c-diamide synthase activity
MCHL_RS05600	COG1396	sequence-specific DNA binding
MCHL_RS05610	COG2223	nitrite transmembrane transporter activity
MCHL_RS05615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MCHL_RS05620	COG0735	belongs to the Fur family
MCHL_RS05625	COG1121	(ABC) transporter
MCHL_RS05645	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MCHL_RS05660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCHL_RS05665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MCHL_RS05670	COG0683	leucine binding
MCHL_RS05680	COG3608	succinylglutamate desuccinylase aspartoacylase
MCHL_RS05680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MCHL_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS05710	COG3932	Exopolysaccharide synthesis, ExoD
MCHL_RS05715	COG1136	(ABC) transporter
MCHL_RS05735	COG0346	lactoylglutathione lyase activity
MCHL_RS05750	COG1007	ATP synthesis coupled electron transport
MCHL_RS05765	COG0713	ATP synthesis coupled electron transport
MCHL_RS05775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCHL_RS05780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MCHL_RS05790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MCHL_RS05800	COG0649	NAD binding
MCHL_RS05805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCHL_RS05810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCHL_RS05815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCHL_RS05830	COG3794	PFAM blue (type 1) copper domain protein
MCHL_RS05835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCHL_RS05840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCHL_RS05855	COG0492	ferredoxin-NADP+ reductase activity
MCHL_RS05860	COG0583	DNA-binding transcription factor activity
MCHL_RS05865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MCHL_RS05870	COG0511	ligase activity, forming carbon-carbon bonds
MCHL_RS05880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MCHL_RS05905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCHL_RS05910	COG3158	transport of potassium into the cell
MCHL_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS05940	COG1408	metallophosphoesterase
MCHL_RS05975	COG2815	serine threonine protein kinase
MCHL_RS05975	COG0515	serine threonine protein kinase
MCHL_RS06000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCHL_RS06010	COG2323	membrane
MCHL_RS06015	COG0251	oxidation-reduction process
MCHL_RS06025	COG0583	DNA-binding transcription factor activity
MCHL_RS06035	COG0583	DNA-binding transcription factor activity
MCHL_RS06040	COG2358	TRAP transporter, solute receptor (TAXI family
MCHL_RS06045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS06050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MCHL_RS06065	COG1295	ribonuclease BN
MCHL_RS06105	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MCHL_RS06110	COG4957	zinc ion binding
MCHL_RS06125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCHL_RS06135	COG0569	domain protein
MCHL_RS06135	COG2985	domain, Protein
MCHL_RS06140	COG1554	hydrolase, family 65, central catalytic
MCHL_RS06145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCHL_RS06150	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MCHL_RS06190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS06190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCHL_RS06200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCHL_RS06245	COG0640	Transcriptional regulator
MCHL_RS06250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS06250	COG1116	anion transmembrane transporter activity
MCHL_RS06255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS06260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS06265	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCHL_RS06285	COG4977	sequence-specific DNA binding
MCHL_RS06295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCHL_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS06355	COG1116	anion transmembrane transporter activity
MCHL_RS06355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS06360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS06370	COG1960	acyl-CoA dehydrogenase activity
MCHL_RS06375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCHL_RS06380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS06400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS06405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MCHL_RS06410	COG0492	ferredoxin-NADP+ reductase activity
MCHL_RS06415	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCHL_RS06435	COG1278	Cold shock
MCHL_RS06460	COG2202	Pas domain
MCHL_RS06460	COG3920	Histidine kinase
MCHL_RS06470	COG4716	Myosin-crossreactive antigen
MCHL_RS06485	COG0830	nickel cation binding
MCHL_RS06490	COG0831	urea catabolic process
MCHL_RS06490	COG0832	Belongs to the urease beta subunit family
MCHL_RS06495	COG0804	urea catabolic process
MCHL_RS06500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MCHL_RS06505	COG0829	nickel cation binding
MCHL_RS06540	COG4191	Histidine kinase
MCHL_RS06595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MCHL_RS06600	COG1802	Transcriptional regulator
MCHL_RS06605	COG0523	cobalamin synthesis protein
MCHL_RS06610	COG1686	Belongs to the peptidase S11 family
MCHL_RS06615	COG0602	queuosine metabolic process
MCHL_RS06635	COG0720	synthase
MCHL_RS06645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MCHL_RS06680	COG0297	glycogen (starch) synthase activity
MCHL_RS06700	COG0642	Histidine kinase
MCHL_RS06705	COG0745	RESPONSE REGULATOR receiver
MCHL_RS06735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MCHL_RS06760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MCHL_RS06765	COG1403	HNH endonuclease
MCHL_RS06770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS06770	COG3453	Protein conserved in bacteria
MCHL_RS06775	COG0024	Methionine aminopeptidase
MCHL_RS06790	COG3246	L-lysine catabolic process to acetate
MCHL_RS06800	COG4191	Histidine kinase
MCHL_RS06805	COG1116	anion transmembrane transporter activity
MCHL_RS06810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS06815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS06820	COG0850	regulation of cytokinetic process
MCHL_RS06830	COG1217	gtp-binding protein TYPA
MCHL_RS06840	COG0850	regulation of cytokinetic process
MCHL_RS06860	COG3386	PFAM SMP-30 Gluconolaconase
MCHL_RS06865	COG3387	PFAM Glycoside hydrolase 15-related
MCHL_RS06870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCHL_RS06885	COG4166	transmembrane transport
MCHL_RS06895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCHL_RS06905	COG0444	Belongs to the ABC transporter superfamily
MCHL_RS06970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MCHL_RS06995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MCHL_RS07000	COG0004	ammonium transporteR
MCHL_RS07010	COG0829	nickel cation binding
MCHL_RS07015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MCHL_RS07020	COG0830	nickel cation binding
MCHL_RS07040	COG0804	urea catabolic process
MCHL_RS07050	COG0831	urea catabolic process
MCHL_RS07145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MCHL_RS07190	COG0410	ABC transporter
MCHL_RS07200	COG1172	Belongs to the binding-protein-dependent transport system permease family
MCHL_RS07225	COG2133	pyrroloquinoline quinone binding
MCHL_RS07230	COG0596	Alpha beta hydrolase
MCHL_RS07250	COG3181	Tripartite tricarboxylate transporter family receptor
MCHL_RS07255	COG0300	oxidoreductase activity
MCHL_RS07260	COG0588	phosphoglycerate mutase activity
MCHL_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS07310	COG4191	Histidine kinase
MCHL_RS07310	COG0784	Response regulator, receiver
MCHL_RS07315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MCHL_RS07315	COG2124	cytochrome p450
MCHL_RS07320	COG3300	MHYT domain
MCHL_RS07320	COG5001	Diguanylate cyclase
MCHL_RS07365	COG0477	Major facilitator Superfamily
MCHL_RS07415	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS07425	COG3246	L-lysine catabolic process to acetate
MCHL_RS07430	COG0589	response to stress
MCHL_RS07440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS07445	COG1132	(ABC) transporter
MCHL_RS07455	COG1271	oxidase subunit
MCHL_RS07460	COG1294	oxidase, subunit
MCHL_RS07470	COG1349	DNA-binding transcription factor activity
MCHL_RS07475	COG0154	amidase activity
MCHL_RS07490	COG1215	transferase activity, transferring glycosyl groups
MCHL_RS07705	COG3728	DNA packaging
MCHL_RS07705	COG5484	DNA packaging
MCHL_RS07785	COG3750	Belongs to the UPF0335 family
MCHL_RS07905	COG0582	viral genome integration into host DNA
MCHL_RS07950	COG1999	signal sequence binding
MCHL_RS07975	COG1802	Transcriptional regulator
MCHL_RS07980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MCHL_RS08020	COG2373	Large extracellular alpha-helical protein
MCHL_RS08025	COG4953	penicillin-binding protein 1C
MCHL_RS08030	COG2076	Multidrug Resistance protein
MCHL_RS08070	COG3088	subunit of a heme lyase
MCHL_RS08075	COG1138	Cytochrome C-type biogenesis protein
MCHL_RS08085	COG4235	cytochrome complex assembly
MCHL_RS08210	COG4695	Portal protein
MCHL_RS08295	COG0114	fumarate hydratase activity
MCHL_RS08320	COG0840	transmembrane signaling receptor activity
MCHL_RS08325	COG0784	Response regulator, receiver
MCHL_RS08325	COG4191	Histidine kinase
MCHL_RS08335	COG2207	Transcriptional regulator
MCHL_RS08335	COG3708	Transcriptional regulator
MCHL_RS08355	COG0714	Associated with various cellular activities
MCHL_RS08370	COG0494	nUDIX hydrolase
MCHL_RS08380	COG0617	tRNA 3'-terminal CCA addition
MCHL_RS08385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MCHL_RS08395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCHL_RS08405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MCHL_RS08415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MCHL_RS08430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MCHL_RS08450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCHL_RS08475	COG1051	belongs to the nudix hydrolase family
MCHL_RS08490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MCHL_RS08505	COG0237	dephospho-CoA kinase activity
MCHL_RS08510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MCHL_RS08520	COG0424	maF-like protein
MCHL_RS08530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MCHL_RS08535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCHL_RS08545	COG1981	membrane
MCHL_RS08555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MCHL_RS08560	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MCHL_RS08605	COG0314	molybdopterin synthase activity
MCHL_RS08615	COG0579	oxidoreductase
MCHL_RS08620	COG3552	Protein containing von Willebrand factor type A (VWA) domain
MCHL_RS08630	COG0714	Associated with various cellular activities
MCHL_RS08645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MCHL_RS08650	COG3609	addiction module antidote protein, CC2985 family
MCHL_RS08660	COG1573	uracil-dna glycosylase
MCHL_RS08700	COG1051	belongs to the nudix hydrolase family
MCHL_RS08705	COG0288	reversible hydration of carbon dioxide
MCHL_RS08710	COG1218	3'(2'),5'-bisphosphate nucleotidase
MCHL_RS08720	COG0643	Histidine kinase
MCHL_RS08720	COG2198	Histidine kinase
MCHL_RS08720	COG0784	Response regulator, receiver
MCHL_RS08735	COG2201	protein-glutamate methylesterase activity
MCHL_RS08750	COG1984	allophanate hydrolase subunit 2
MCHL_RS08785	COG2086	electron transfer activity
MCHL_RS08790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MCHL_RS08795	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCHL_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS08805	COG3321	synthase
MCHL_RS08805	COG0604	alcohol dehydrogenase
MCHL_RS08810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MCHL_RS08820	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MCHL_RS08845	COG0124	histidyl-tRNA synthetase
MCHL_RS08850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCHL_RS08865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MCHL_RS08885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MCHL_RS08890	COG0028	Belongs to the TPP enzyme family
MCHL_RS08900	COG1253	flavin adenine dinucleotide binding
MCHL_RS08920	COG0671	phosphoesterase, PA-phosphatase related
MCHL_RS08935	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
MCHL_RS08940	COG2171	N-acyltransferase activity
MCHL_RS08950	COG0745	RESPONSE REGULATOR receiver
MCHL_RS08965	COG0495	leucyl-tRNA aminoacylation
MCHL_RS08970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MCHL_RS08985	COG0445	tRNA wobble uridine modification
MCHL_RS09040	COG0287	Prephenate dehydrogenase
MCHL_RS09045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCHL_RS09055	COG4774	siderophore transport
MCHL_RS09060	COG3158	transport of potassium into the cell
MCHL_RS09065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCHL_RS09075	COG2226	methyltransferase
MCHL_RS09120	COG1272	protein, Hemolysin III
MCHL_RS09130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MCHL_RS09140	COG5442	Flagellar protein FlaF
MCHL_RS09165	COG0848	biopolymer transport protein
MCHL_RS09195	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS09210	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS09215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MCHL_RS09225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MCHL_RS09235	COG0653	protein targeting
MCHL_RS09255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCHL_RS09260	COG0242	peptide deformylase activity
MCHL_RS09270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MCHL_RS09275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MCHL_RS09280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MCHL_RS09295	COG0039	L-malate dehydrogenase activity
MCHL_RS09300	COG0045	succinate-CoA ligase (ADP-forming) activity
MCHL_RS09305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MCHL_RS09315	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCHL_RS09320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCHL_RS09325	COG4191	Histidine kinase
MCHL_RS09325	COG0784	Response regulator, receiver
MCHL_RS09340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MCHL_RS09340	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCHL_RS09350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCHL_RS09360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MCHL_RS09365	COG2218	PFAM glutamate synthase alpha subunit domain protein
MCHL_RS09370	COG0069	glutamate synthase activity
MCHL_RS09505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCHL_RS09550	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MCHL_RS09560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS09575	COG2197	response regulator
MCHL_RS09590	COG5002	protein histidine kinase activity
MCHL_RS09590	COG0784	Response regulator, receiver
MCHL_RS09595	COG4191	Histidine kinase
MCHL_RS09595	COG0784	Response regulator, receiver
MCHL_RS09600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS09605	COG0583	DNA-binding transcription factor activity
MCHL_RS09625	COG1335	isochorismatase
MCHL_RS09635	COG0583	DNA-binding transcription factor activity
MCHL_RS09650	COG1388	LysM domain
MCHL_RS09650	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS09655	COG0583	DNA-binding transcription factor activity
MCHL_RS09680	COG0697	spore germination
MCHL_RS09700	COG0154	amidase activity
MCHL_RS09705	COG2233	PERMEase
MCHL_RS09740	COG3845	ABC transporter
MCHL_RS09765	COG1079	Belongs to the binding-protein-dependent transport system permease family
MCHL_RS09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCHL_RS09780	COG3845	ABC transporter
MCHL_RS09815	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS09820	COG2249	NAD(P)H dehydrogenase (quinone) activity
MCHL_RS09845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS09860	COG0583	DNA-binding transcription factor activity
MCHL_RS09865	COG0402	S-adenosylhomocysteine deaminase activity
MCHL_RS09880	COG0583	DNA-binding transcription factor activity
MCHL_RS09885	COG0402	S-adenosylhomocysteine deaminase activity
MCHL_RS09890	COG2080	2 iron, 2 sulfur cluster binding
MCHL_RS09890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCHL_RS09900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS09905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS09910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS09915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MCHL_RS09930	COG0251	oxidation-reduction process
MCHL_RS09945	COG1309	transcriptional regulator
MCHL_RS09950	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
MCHL_RS09955	COG3257	ureidoglycine aminohydrolase activity
MCHL_RS09965	COG0583	DNA-binding transcription factor activity
MCHL_RS09970	COG3648	Uricase
MCHL_RS09970	COG3195	allantoin biosynthetic process
MCHL_RS09975	COG2351	hydroxyisourate hydrolase activity
MCHL_RS09980	COG2080	2 iron, 2 sulfur cluster binding
MCHL_RS09985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCHL_RS10035	COG1744	ABC transporter substrate-binding protein PnrA-like
MCHL_RS10040	COG3845	ABC transporter
MCHL_RS10045	COG4603	Belongs to the binding-protein-dependent transport system permease family
MCHL_RS10050	COG1079	Belongs to the binding-protein-dependent transport system permease family
MCHL_RS10065	COG2354	Protein conserved in bacteria
MCHL_RS10105	COG0405	Gamma-glutamyltransferase
MCHL_RS10130	COG2813	Specifically methylates the guanine in position
MCHL_RS10130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MCHL_RS10135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MCHL_RS10145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCHL_RS10160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MCHL_RS10185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCHL_RS10190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MCHL_RS10195	COG3118	belongs to the thioredoxin family
MCHL_RS10220	COG0523	cobalamin synthesis protein
MCHL_RS10240	COG3106	COG3106 Predicted ATPase
MCHL_RS10245	COG3768	UPF0283 membrane protein
MCHL_RS10285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCHL_RS10290	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS10300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MCHL_RS10305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCHL_RS10310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCHL_RS10315	COG3404	Formiminotransferase-cyclodeaminase
MCHL_RS10320	COG0045	succinate-CoA ligase (ADP-forming) activity
MCHL_RS10325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MCHL_RS10330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MCHL_RS10345	COG0412	Dienelactone hydrolase
MCHL_RS10350	COG2154	pterin-4-alpha-carbinolamine dehydratase
MCHL_RS10385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCHL_RS10390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MCHL_RS10395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MCHL_RS10410	COG0535	radical SAM domain protein
MCHL_RS10415	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
MCHL_RS10445	COG2218	PFAM glutamate synthase alpha subunit domain protein
MCHL_RS10450	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MCHL_RS10455	COG1229	Formylmethanofuran dehydrogenase subunit A
MCHL_RS10460	COG1029	Formylmethanofuran dehydrogenase, subunit B
MCHL_RS10470	COG0702	epimerase
MCHL_RS10475	COG1181	Belongs to the D-alanine--D-alanine ligase family
MCHL_RS10480	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MCHL_RS10485	COG0189	ligase activity
MCHL_RS10495	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MCHL_RS10575	COG1131	(ABC) transporter
MCHL_RS10625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MCHL_RS10630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MCHL_RS10645	COG0606	chelatase, subunit chli
MCHL_RS10650	COG0625	glutathione transferase activity
MCHL_RS10675	COG1607	acyl-coa hydrolase
MCHL_RS10685	COG0741	lytic transglycosylase activity
MCHL_RS10690	COG0243	molybdopterin cofactor binding
MCHL_RS10695	COG4172	Belongs to the ABC transporter superfamily
MCHL_RS10725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCHL_RS10730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS10735	COG1562	ergosterol biosynthetic process
MCHL_RS10740	COG1562	ergosterol biosynthetic process
MCHL_RS10745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MCHL_RS10750	COG1657	PFAM Prenyltransferase squalene oxidase
MCHL_RS10760	COG0156	8-amino-7-oxononanoate synthase activity
MCHL_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS10765	COG0604	alcohol dehydrogenase
MCHL_RS10765	COG3321	synthase
MCHL_RS10770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MCHL_RS10775	COG1216	Glycosyl transferase, family 2
MCHL_RS10775	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS10795	COG4303	Ethanolamine ammonia lyase large subunit
MCHL_RS10800	COG4302	ethanolamine ammonia-lyase activity
MCHL_RS10805	COG0129	dihydroxy-acid dehydratase activity
MCHL_RS10840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MCHL_RS10855	COG1494	fructose-1,6-bisphosphatase
MCHL_RS10880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MCHL_RS10885	COG2264	protein methyltransferase activity
MCHL_RS10910	COG1271	oxidase subunit
MCHL_RS10920	COG3706	GGDEF domain
MCHL_RS10935	COG0672	)-iron permease
MCHL_RS10945	COG5328	Belongs to the UPF0262 family
MCHL_RS10950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MCHL_RS10970	COG0156	8-amino-7-oxononanoate synthase activity
MCHL_RS10990	COG2824	Alkylphosphonate utilization operon protein PhnA
MCHL_RS10995	COG1234	tRNA 3'-trailer cleavage
MCHL_RS11005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MCHL_RS11020	COG1561	YicC-like family, N-terminal region
MCHL_RS11025	COG0194	GDP metabolic process
MCHL_RS11030	COG1132	(ABC) transporter
MCHL_RS11035	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS11040	COG0778	Nitroreductase
MCHL_RS11050	COG4774	siderophore transport
MCHL_RS11055	COG0800	Aldolase
MCHL_RS11060	COG0129	dihydroxy-acid dehydratase activity
MCHL_RS11100	COG2879	small protein
MCHL_RS11105	COG1966	Carbon starvation protein
MCHL_RS11115	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MCHL_RS11120	COG1704	LemA family
MCHL_RS11130	COG5001	Diguanylate cyclase
MCHL_RS11145	COG0297	glycogen (starch) synthase activity
MCHL_RS11155	COG0058	SHG alpha-glucan phosphorylase activity
MCHL_RS11170	COG5001	Diguanylate cyclase
MCHL_RS11175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCHL_RS11180	COG0702	epimerase
MCHL_RS11190	COG1733	regulation of RNA biosynthetic process
MCHL_RS11195	COG1086	Polysaccharide biosynthesis protein
MCHL_RS11250	COG1902	pentaerythritol trinitrate reductase activity
MCHL_RS11255	COG0546	phosphoglycolate phosphatase activity
MCHL_RS11275	COG0416	fatty acid biosynthetic process
MCHL_RS11280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCHL_RS11285	COG0776	regulation of translation
MCHL_RS11305	COG2766	serine protein kinase
MCHL_RS11310	COG2718	Belongs to the UPF0229 family
MCHL_RS11315	COG2719	SpoVR family
MCHL_RS11320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MCHL_RS11325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MCHL_RS11330	COG0628	permease
MCHL_RS11340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MCHL_RS11355	COG0436	Aminotransferase
MCHL_RS11370	COG0052	Belongs to the universal ribosomal protein uS2 family
MCHL_RS11375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MCHL_RS11380	COG0528	UMP kinase activity
MCHL_RS11385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MCHL_RS11410	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCHL_RS11415	COG0750	zinc metalloprotease
MCHL_RS11420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MCHL_RS11430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCHL_RS11435	COG0233	cytoplasmic translational termination
MCHL_RS11445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCHL_RS11450	COG0583	DNA-binding transcription factor activity
MCHL_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS11460	COG3959	Transketolase, thiamine diphosphate binding domain
MCHL_RS11465	COG3958	Transketolase
MCHL_RS11470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MCHL_RS11490	COG1946	Acyl-CoA thioesterase
MCHL_RS11495	COG0347	Belongs to the P(II) protein family
MCHL_RS11500	COG0004	ammonium transporteR
MCHL_RS11510	COG1674	ftsk spoiiie
MCHL_RS11520	COG3920	Histidine kinase
MCHL_RS11530	COG0243	molybdopterin cofactor binding
MCHL_RS11560	COG1045	serine acetyltransferase
MCHL_RS11565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MCHL_RS11570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCHL_RS11570	COG4191	Histidine kinase
MCHL_RS11590	COG0784	Response regulator, receiver
MCHL_RS11590	COG3437	response regulator, receiver
MCHL_RS11625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCHL_RS11650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MCHL_RS11670	COG1819	glycosyl
MCHL_RS11680	COG5001	Diguanylate cyclase
MCHL_RS11700	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCHL_RS11705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MCHL_RS11710	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS11740	COG1942	4-Oxalocrotonate Tautomerase
MCHL_RS11755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCHL_RS11770	COG0583	DNA-binding transcription factor activity
MCHL_RS11775	COG0346	lactoylglutathione lyase activity
MCHL_RS11780	COG0400	carboxylic ester hydrolase activity
MCHL_RS11795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MCHL_RS11800	COG0049	tRNA binding
MCHL_RS11805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCHL_RS11810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCHL_RS11815	COG0051	transcription antitermination factor activity, RNA binding
MCHL_RS11825	COG0088	Forms part of the polypeptide exit tunnel
MCHL_RS11830	COG0089	rRNA binding
MCHL_RS11835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCHL_RS11840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MCHL_RS11845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MCHL_RS11850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCHL_RS11855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MCHL_RS11860	COG0255	Belongs to the universal ribosomal protein uL29 family
MCHL_RS11865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MCHL_RS11870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCHL_RS11880	COG1846	Transcriptional regulator
MCHL_RS11900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MCHL_RS11905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MCHL_RS11915	COG0201	protein transport
MCHL_RS11920	COG0200	Binds to the 23S rRNA
MCHL_RS11925	COG1841	ribosomal large subunit assembly
MCHL_RS11930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MCHL_RS11935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MCHL_RS11940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MCHL_RS11945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MCHL_RS11950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MCHL_RS11955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCHL_RS11960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MCHL_RS11965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MCHL_RS12020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCHL_RS12030	COG0024	Methionine aminopeptidase
MCHL_RS12035	COG2003	Belongs to the UPF0758 family
MCHL_RS12040	COG2308	Evidence 4 Homologs of previously reported genes of
MCHL_RS12075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MCHL_RS12080	COG1253	flavin adenine dinucleotide binding
MCHL_RS12100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCHL_RS12130	COG5001	Diguanylate cyclase
MCHL_RS12160	COG0175	sulfate reduction
MCHL_RS12165	COG0175	sulfate reduction
MCHL_RS12170	COG1522	sequence-specific DNA binding
MCHL_RS12175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MCHL_RS12185	COG4774	siderophore transport
MCHL_RS12205	COG0629	single-stranded DNA binding
MCHL_RS12210	COG2130	NADP-dependent
MCHL_RS12225	COG3698	Phosphodiester glycosidase
MCHL_RS12230	COG1902	pentaerythritol trinitrate reductase activity
MCHL_RS12235	COG0435	Glutathione S-transferase
MCHL_RS12245	COG3118	belongs to the thioredoxin family
MCHL_RS12255	COG2835	tetraacyldisaccharide 4'-kinase activity
MCHL_RS12265	COG4191	Histidine kinase
MCHL_RS12265	COG0784	Response regulator, receiver
MCHL_RS12300	COG2239	Acts as a magnesium transporter
MCHL_RS12305	COG1752	Esterase of the alpha-beta hydrolase superfamily
MCHL_RS12310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MCHL_RS12315	COG0302	gtp cyclohydrolase
MCHL_RS12325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MCHL_RS12330	COG0670	Belongs to the BI1 family
MCHL_RS12340	COG4191	Histidine kinase
MCHL_RS12345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MCHL_RS12355	COG0681	Belongs to the peptidase S26 family
MCHL_RS12360	COG0571	ribonuclease III activity
MCHL_RS12365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MCHL_RS12375	COG1187	pseudouridine synthase activity
MCHL_RS12400	COG3158	transport of potassium into the cell
MCHL_RS12410	COG0494	nUDIX hydrolase
MCHL_RS12425	COG0793	Belongs to the peptidase S41A family
MCHL_RS12435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MCHL_RS12445	COG5001	Diguanylate cyclase
MCHL_RS12445	COG3300	MHYT domain
MCHL_RS12455	COG0137	argininosuccinate synthase activity
MCHL_RS12470	COG0546	phosphoglycolate phosphatase activity
MCHL_RS12505	COG2137	regulation of response to DNA damage stimulus
MCHL_RS12510	COG1764	response to oxidative stress
MCHL_RS12520	COG1573	uracil-dna glycosylase
MCHL_RS12550	COG0625	glutathione transferase activity
MCHL_RS12560	COG0753	catalase activity
MCHL_RS12570	COG0778	Nitroreductase
MCHL_RS12585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCHL_RS12595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCHL_RS12605	COG1940	carbohydrate kinase activity
MCHL_RS12610	COG1301	dicarboxylic acid transport
MCHL_RS12615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MCHL_RS12620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MCHL_RS12630	COG0612	Peptidase, M16
MCHL_RS12635	COG0612	Peptidase, M16
MCHL_RS12650	COG0346	lactoylglutathione lyase activity
MCHL_RS12660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MCHL_RS12710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCHL_RS12735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MCHL_RS12740	COG2031	fatty acid transporter
MCHL_RS12750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MCHL_RS12760	COG0594	ribonuclease P activity
MCHL_RS12765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MCHL_RS12775	COG0254	rRNA binding
MCHL_RS12780	COG1132	(ABC) transporter
MCHL_RS12785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MCHL_RS12800	COG1692	metallophosphoesterase
MCHL_RS12805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MCHL_RS12850	COG0531	amino acid
MCHL_RS12855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MCHL_RS12855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MCHL_RS12860	COG0347	Belongs to the P(II) protein family
MCHL_RS12870	COG0174	glutamine synthetase
MCHL_RS12875	COG0174	glutamine synthetase
MCHL_RS12880	COG0431	NADPH-dependent FMN reductase
MCHL_RS12890	COG0557	exoribonuclease II activity
MCHL_RS12915	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MCHL_RS12925	COG1968	undecaprenyl-diphosphatase activity
MCHL_RS12950	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MCHL_RS12955	COG1088	dTDP-glucose 4,6-dehydratase activity
MCHL_RS12960	COG1091	dTDP-4-dehydrorhamnose reductase activity
MCHL_RS12970	COG3161	chorismate lyase activity
MCHL_RS13000	COG0544	peptidyl-prolyl cis-trans isomerase activity
MCHL_RS13005	COG0740	serine-type endopeptidase activity
MCHL_RS13010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCHL_RS13015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MCHL_RS13030	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS13050	COG3665	Urea carboxylase-associated protein
MCHL_RS13055	COG1297	OPT oligopeptide transporter protein
MCHL_RS13075	COG1295	ribonuclease BN
MCHL_RS13085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCHL_RS13085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCHL_RS13090	COG1515	deoxyribonuclease V activity
MCHL_RS13095	COG0012	GTP binding
MCHL_RS13100	COG0193	aminoacyl-tRNA hydrolase activity
MCHL_RS13130	COG4964	Belongs to the GSP D family
MCHL_RS13160	COG2030	dehydratase
MCHL_RS13165	COG0477	Major facilitator Superfamily
MCHL_RS13170	COG1764	response to oxidative stress
MCHL_RS13175	COG1832	CoA-binding protein
MCHL_RS13190	COG2203	Gaf domain
MCHL_RS13190	COG3706	GGDEF domain
MCHL_RS13190	COG4251	negative regulation of phosphorylation
MCHL_RS13190	COG5001	Diguanylate cyclase
MCHL_RS13215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCHL_RS13230	COG1137	ATPase activity
MCHL_RS13235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MCHL_RS13240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MCHL_RS13245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCHL_RS13260	COG0588	phosphoglycerate mutase activity
MCHL_RS13265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MCHL_RS13280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS13290	COG4974	Belongs to the 'phage' integrase family
MCHL_RS13305	COG4239	(ABC) transporter, permease
MCHL_RS13315	COG0436	Aminotransferase
MCHL_RS13325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCHL_RS13340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MCHL_RS13345	COG0473	3-isopropylmalate dehydrogenase activity
MCHL_RS13365	COG3011	Protein conserved in bacteria
MCHL_RS13375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCHL_RS13380	COG0415	Belongs to the DNA photolyase family
MCHL_RS13385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MCHL_RS13405	COG1368	sulfuric ester hydrolase activity
MCHL_RS13425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCHL_RS13435	COG0723	plastoquinol--plastocyanin reductase activity
MCHL_RS13440	COG2857	Cytochrome c1
MCHL_RS13440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCHL_RS13445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCHL_RS13445	COG2857	Cytochrome c1
MCHL_RS13450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MCHL_RS13475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MCHL_RS13480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MCHL_RS13490	COG0140	phosphoribosyl-ATP diphosphatase activity
MCHL_RS13495	COG1072	(Pantothenic acid kinase))
MCHL_RS13515	COG1388	LysM domain
MCHL_RS13515	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS13540	COG3162	membrane
MCHL_RS13555	COG0138	bifunctional purine biosynthesis protein purh
MCHL_RS13565	COG2897	thiosulfate sulfurtransferase activity
MCHL_RS13580	COG0513	Belongs to the DEAD box helicase family
MCHL_RS13600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS13615	COG1970	mechanosensitive ion channel activity
MCHL_RS13630	COG0436	Aminotransferase
MCHL_RS13645	COG0745	RESPONSE REGULATOR receiver
MCHL_RS13650	COG1846	Transcriptional regulator
MCHL_RS13655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MCHL_RS13675	COG0534	Mate efflux family protein
MCHL_RS13680	COG0475	glutathione-regulated potassium exporter activity
MCHL_RS13680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCHL_RS13685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCHL_RS13690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MCHL_RS13700	COG1678	Uncharacterized ACR, COG1678
MCHL_RS13710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCHL_RS13715	COG2378	regulation of single-species biofilm formation
MCHL_RS13720	COG0625	glutathione transferase activity
MCHL_RS13725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MCHL_RS13740	COG1684	flagellar biosynthetic protein fliR
MCHL_RS13745	COG1987	bacterial-type flagellum assembly
MCHL_RS13750	COG1677	Flagellar hook-basal body complex protein FliE
MCHL_RS13755	COG1558	bacterial-type flagellum-dependent cell motility
MCHL_RS13760	COG1815	bacterial-type flagellum-dependent cell motility
MCHL_RS13770	COG0579	oxidoreductase
MCHL_RS13780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCHL_RS13790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCHL_RS13795	COG0247	lactate metabolic process
MCHL_RS13800	COG1139	Iron-sulfur cluster binding protein
MCHL_RS13815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MCHL_RS13820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCHL_RS13840	COG1132	(ABC) transporter
MCHL_RS13865	COG0424	maF-like protein
MCHL_RS13885	COG4774	siderophore transport
MCHL_RS13900	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCHL_RS13905	COG4133	protoheme IX ABC transporter activity
MCHL_RS13915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MCHL_RS13930	COG0625	glutathione transferase activity
MCHL_RS13935	COG1252	NADH dehydrogenase
MCHL_RS13950	COG0840	transmembrane signaling receptor activity
MCHL_RS13960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MCHL_RS13970	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS13970	COG1388	LysM domain
MCHL_RS14005	COG2084	Dehydrogenase
MCHL_RS14015	COG0560	Phosphoserine phosphatase
MCHL_RS14025	COG0330	HflC and HflK could
MCHL_RS14030	COG0330	HflC and HflK could
MCHL_RS14055	COG2124	cytochrome p450
MCHL_RS14060	COG0114	fumarate hydratase activity
MCHL_RS14085	COG0586	Pfam SNARE associated Golgi protein
MCHL_RS14090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MCHL_RS14095	COG0384	phenazine biosynthesis protein PhzF
MCHL_RS14110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCHL_RS14125	COG4948	Mandelate Racemase Muconate Lactonizing
MCHL_RS14150	COG0673	inositol 2-dehydrogenase activity
MCHL_RS14165	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS14180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MCHL_RS14180	COG0392	lysyltransferase activity
MCHL_RS14185	COG5002	protein histidine kinase activity
MCHL_RS14195	COG0789	Transcriptional regulator
MCHL_RS14200	COG1473	amidohydrolase
MCHL_RS14205	COG0840	transmembrane signaling receptor activity
MCHL_RS14210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MCHL_RS14220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCHL_RS14235	COG0779	Required for maturation of 30S ribosomal subunits
MCHL_RS14240	COG0110	maltose O-acetyltransferase activity
MCHL_RS14245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MCHL_RS14260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCHL_RS14270	COG0523	cobalamin synthesis protein
MCHL_RS14275	COG1309	transcriptional regulator
MCHL_RS14285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MCHL_RS14295	COG0366	Alpha amylase catalytic
MCHL_RS14300	COG0366	Alpha amylase catalytic
MCHL_RS14305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MCHL_RS14310	COG1742	UPF0060 membrane protein
MCHL_RS14340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCHL_RS14345	COG0564	pseudouridine synthase activity
MCHL_RS14350	COG0552	protein localization to endoplasmic reticulum
MCHL_RS14370	COG0142	geranyltranstransferase activity
MCHL_RS14375	COG0500	methyltransferase
MCHL_RS14380	COG1063	alcohol dehydrogenase
MCHL_RS14385	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MCHL_RS14390	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCHL_RS14395	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCHL_RS14430	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MCHL_RS14435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS14440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MCHL_RS14450	COG2267	carboxylic ester hydrolase activity
MCHL_RS14455	COG0469	pyruvate kinase activity
MCHL_RS14485	COG3750	Belongs to the UPF0335 family
MCHL_RS14500	COG2204	response regulator
MCHL_RS14520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MCHL_RS14580	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MCHL_RS14585	COG3604	Transcriptional regulator
MCHL_RS14595	COG1858	cytochrome C peroxidase
MCHL_RS14605	COG5001	Diguanylate cyclase
MCHL_RS14605	COG3300	MHYT domain
MCHL_RS14610	COG3546	catalase activity
MCHL_RS14645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MCHL_RS14660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MCHL_RS14670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MCHL_RS14675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MCHL_RS14680	COG0022	dehydrogenase e1 component
MCHL_RS14680	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCHL_RS14690	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCHL_RS14695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCHL_RS14740	COG2867	negative regulation of translational initiation
MCHL_RS14750	COG2423	ornithine cyclodeaminase activity
MCHL_RS14755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCHL_RS14765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCHL_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS14775	COG4638	Rieske (2fe-2S)
MCHL_RS14780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCHL_RS14795	COG5265	(ABC) transporter
MCHL_RS14800	COG2080	2 iron, 2 sulfur cluster binding
MCHL_RS14805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MCHL_RS14810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCHL_RS14820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MCHL_RS14820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MCHL_RS14825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCHL_RS14835	COG2204	response regulator
MCHL_RS14840	COG1061	Type III restriction enzyme res subunit
MCHL_RS14845	COG5000	phosphorelay sensor kinase activity
MCHL_RS14850	COG2204	response regulator
MCHL_RS14855	COG1923	regulation of RNA biosynthetic process
MCHL_RS14860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MCHL_RS14865	COG0659	secondary active sulfate transmembrane transporter activity
MCHL_RS14905	COG4957	zinc ion binding
MCHL_RS14965	COG0303	'Molybdopterin
MCHL_RS14970	COG1763	Mo-molybdopterin cofactor biosynthetic process
MCHL_RS14975	COG0303	'Molybdopterin
MCHL_RS14985	COG4662	Binding-protein-dependent transport system inner membrane component
MCHL_RS15010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MCHL_RS15015	COG2943	transferase activity, transferring hexosyl groups
MCHL_RS15030	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MCHL_RS15035	COG2204	response regulator
MCHL_RS15040	COG0037	tRNA processing
MCHL_RS15040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MCHL_RS15050	COG2884	Cell division ATP-binding protein ftsE
MCHL_RS15070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MCHL_RS15085	COG0799	negative regulation of ribosome biogenesis
MCHL_RS15105	COG1132	(ABC) transporter
MCHL_RS15115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MCHL_RS15120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MCHL_RS15125	COG0322	excinuclease ABC activity
MCHL_RS15135	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS15145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCHL_RS15150	COG1496	oxidoreductase activity
MCHL_RS15160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MCHL_RS15165	COG1285	pathogenesis
MCHL_RS15170	COG0033	Phosphoglucomutase
MCHL_RS15190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCHL_RS15190	COG0574	Belongs to the PEP-utilizing enzyme family
MCHL_RS15195	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS15200	COG0346	lactoylglutathione lyase activity
MCHL_RS15210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS15210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCHL_RS15230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS15250	COG0784	Response regulator, receiver
MCHL_RS15265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MCHL_RS15275	COG1408	metallophosphoesterase
MCHL_RS15300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MCHL_RS15310	COG1686	Belongs to the peptidase S11 family
MCHL_RS15350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MCHL_RS15355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCHL_RS15365	COG3657	addiction module killer protein
MCHL_RS15370	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCHL_RS15375	COG0519	Catalyzes the synthesis of GMP from XMP
MCHL_RS15375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCHL_RS15390	COG2755	lipolytic protein G-D-S-L family
MCHL_RS15390	COG0657	acetylesterase activity
MCHL_RS15395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MCHL_RS15395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCHL_RS15405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MCHL_RS15435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCHL_RS15460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MCHL_RS15465	COG0849	cell division
MCHL_RS15470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MCHL_RS15480	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCHL_RS15510	COG0243	molybdopterin cofactor binding
MCHL_RS15530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCHL_RS15545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MCHL_RS15555	COG0295	cytidine deaminase activity
MCHL_RS15570	COG1519	Transferase
MCHL_RS15590	COG1278	Cold shock
MCHL_RS15595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MCHL_RS15605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MCHL_RS15630	COG0739	heme binding
MCHL_RS15630	COG0741	lytic transglycosylase activity
MCHL_RS15630	COG1196	nuclear chromosome segregation
MCHL_RS15635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCHL_RS15645	COG3239	Fatty acid desaturase
MCHL_RS15650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MCHL_RS15670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCHL_RS15670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCHL_RS15675	COG0123	including yeast histone deacetylase and acetoin utilization protein
MCHL_RS15680	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS15690	COG4770	biotin carboxylase activity
MCHL_RS15700	COG1254	Belongs to the acylphosphatase family
MCHL_RS15720	COG0625	glutathione transferase activity
MCHL_RS15725	COG1509	lysine 2,3-aminomutase activity
MCHL_RS15730	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MCHL_RS15745	COG1278	Cold shock
MCHL_RS15765	COG1233	COG1233 Phytoene dehydrogenase and related
MCHL_RS15770	COG1562	ergosterol biosynthetic process
MCHL_RS15775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MCHL_RS15780	COG0830	nickel cation binding
MCHL_RS15785	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MCHL_RS15795	COG0804	urea catabolic process
MCHL_RS15800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCHL_RS15805	COG0831	urea catabolic process
MCHL_RS15805	COG0832	Belongs to the urease beta subunit family
MCHL_RS15810	COG0829	nickel cation binding
MCHL_RS15840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS15845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MCHL_RS15865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MCHL_RS15875	COG2900	Belongs to the SlyX family
MCHL_RS15895	COG1696	Membrane protein involved in D-alanine export
MCHL_RS15910	COG1706	bacterial-type flagellum-dependent cell motility
MCHL_RS15935	COG4786	Flagellar basal body rod
MCHL_RS15940	COG4786	Flagellar basal body rod
MCHL_RS15965	COG0386	Belongs to the glutathione peroxidase family
MCHL_RS15975	COG2951	lytic endotransglycosylase activity
MCHL_RS15980	COG2249	NAD(P)H dehydrogenase (quinone) activity
MCHL_RS15985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCHL_RS15995	COG1301	dicarboxylic acid transport
MCHL_RS16000	COG4191	Histidine kinase
MCHL_RS16005	COG2204	response regulator
MCHL_RS16010	COG3706	GGDEF domain
MCHL_RS16015	COG3300	MHYT domain
MCHL_RS16015	COG5001	Diguanylate cyclase
MCHL_RS16060	COG0343	queuine tRNA-ribosyltransferase activity
MCHL_RS16120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCHL_RS16125	COG1401	restriction endodeoxyribonuclease activity
MCHL_RS16125	COG1401	restriction endodeoxyribonuclease activity
MCHL_RS16140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MCHL_RS16145	COG1061	Type III restriction enzyme res subunit
MCHL_RS16150	COG1002	Type II restriction enzyme, methylase subunits
MCHL_RS16195	COG4974	Belongs to the 'phage' integrase family
MCHL_RS16230	COG5001	Diguanylate cyclase
MCHL_RS16245	COG0784	Response regulator, receiver
MCHL_RS16245	COG4191	Histidine kinase
MCHL_RS16260	COG1366	Belongs to the anti-sigma-factor antagonist family
MCHL_RS16265	COG1366	Belongs to the anti-sigma-factor antagonist family
MCHL_RS16290	COG1280	lysine exporter protein (LysE YggA)
MCHL_RS16300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MCHL_RS16320	COG2323	membrane
MCHL_RS16335	COG4974	Belongs to the 'phage' integrase family
MCHL_RS16375	COG1063	alcohol dehydrogenase
MCHL_RS16470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS16510	COG0582	viral genome integration into host DNA
MCHL_RS16530	COG2954	triphosphatase activity
MCHL_RS16540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MCHL_RS16575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MCHL_RS16590	COG0436	Aminotransferase
MCHL_RS16605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCHL_RS16605	COG4651	solute:proton antiporter activity
MCHL_RS16630	COG0752	glycyl-tRNA synthetase alpha subunit
MCHL_RS16640	COG1309	transcriptional regulator
MCHL_RS16655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCHL_RS16665	COG0142	geranyltranstransferase activity
MCHL_RS16730	COG0187	DNA topoisomerase II activity
MCHL_RS16745	COG1132	(ABC) transporter
MCHL_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS16780	COG2814	Major facilitator Superfamily
MCHL_RS16785	COG2267	carboxylic ester hydrolase activity
MCHL_RS16795	COG0625	glutathione transferase activity
MCHL_RS16815	COG0590	tRNA wobble adenosine to inosine editing
MCHL_RS16835	COG4191	Histidine kinase
MCHL_RS16835	COG0784	Response regulator, receiver
MCHL_RS16845	COG0538	isocitrate dehydrogenase activity
MCHL_RS16860	COG3609	addiction module antidote protein, CC2985 family
MCHL_RS16885	COG2972	Histidine kinase
MCHL_RS16885	COG0840	transmembrane signaling receptor activity
MCHL_RS16895	COG2873	o-acetylhomoserine
MCHL_RS16905	COG0247	lactate metabolic process
MCHL_RS16915	COG0657	acetylesterase activity
MCHL_RS16920	COG1201	RNA secondary structure unwinding
MCHL_RS16940	COG5487	UPF0391 membrane protein
MCHL_RS16945	COG4221	oxidoreductase activity
MCHL_RS16950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MCHL_RS16955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCHL_RS16960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MCHL_RS16965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MCHL_RS16965	COG0546	phosphoglycolate phosphatase activity
MCHL_RS16990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCHL_RS16990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCHL_RS17005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCHL_RS17010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCHL_RS17015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCHL_RS17025	COG0356	it plays a direct role in the translocation of protons across the membrane
MCHL_RS17035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MCHL_RS17055	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MCHL_RS17060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MCHL_RS17075	COG0488	(ABC) transporter
MCHL_RS17100	COG0741	lytic transglycosylase activity
MCHL_RS17105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCHL_RS17110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MCHL_RS17135	COG1758	RNA polymerase activity
MCHL_RS17140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MCHL_RS17145	COG1214	PFAM Peptidase M22, glycoprotease
MCHL_RS17175	COG1702	phosphate starvation-inducible protein PhoH
MCHL_RS17180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MCHL_RS17185	COG1253	flavin adenine dinucleotide binding
MCHL_RS17190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MCHL_RS17200	COG0753	catalase activity
MCHL_RS17210	COG3180	Ammonia monooxygenase
MCHL_RS17235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MCHL_RS17240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MCHL_RS17245	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MCHL_RS17260	COG0243	molybdopterin cofactor binding
MCHL_RS17265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCHL_RS17265	COG1648	precorrin-2 dehydrogenase activity
MCHL_RS17270	COG1999	signal sequence binding
MCHL_RS17325	COG4106	trans-aconitate 2-methyltransferase activity
MCHL_RS17325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MCHL_RS17335	COG1793	dna ligase
MCHL_RS17340	COG0432	Pfam Uncharacterised protein family UPF0047
MCHL_RS17355	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCHL_RS17355	COG1024	Enoyl-CoA hydratase
MCHL_RS17370	COG0183	Belongs to the thiolase family
MCHL_RS17375	COG1960	acyl-CoA dehydrogenase activity
MCHL_RS17400	COG0671	phosphoesterase, PA-phosphatase related
MCHL_RS17405	COG0673	inositol 2-dehydrogenase activity
MCHL_RS17410	COG0612	Peptidase, M16
MCHL_RS17425	COG3346	SURF1 family
MCHL_RS17440	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MCHL_RS17455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCHL_RS17465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MCHL_RS17475	COG0070	glutamate synthase
MCHL_RS17475	COG0069	glutamate synthase activity
MCHL_RS17475	COG0067	glutamate synthase
MCHL_RS17490	COG4585	Histidine kinase
MCHL_RS17505	COG2951	lytic endotransglycosylase activity
MCHL_RS17515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCHL_RS17545	COG4191	Histidine kinase
MCHL_RS17545	COG0784	Response regulator, receiver
MCHL_RS17550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCHL_RS17555	COG2862	Uncharacterized protein family, UPF0114
MCHL_RS17580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCHL_RS17605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCHL_RS17625	COG0728	peptidoglycan biosynthetic process
MCHL_RS17630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MCHL_RS17640	COG3920	Histidine kinase
MCHL_RS17655	COG4783	chaperone-mediated protein folding
MCHL_RS17665	COG1396	sequence-specific DNA binding
MCHL_RS17670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MCHL_RS17675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MCHL_RS17680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MCHL_RS17685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCHL_RS17700	COG0540	Belongs to the ATCase OTCase family
MCHL_RS17715	COG0758	DNA mediated transformation
MCHL_RS17735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MCHL_RS17745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCHL_RS17760	COG2827	Endonuclease containing a URI domain
MCHL_RS17770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS17780	COG1376	ErfK ybiS ycfS ynhG family protein
MCHL_RS17800	COG5425	PFAM Usg family protein
MCHL_RS17805	COG0459	protein refolding
MCHL_RS17810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MCHL_RS17840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS17845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCHL_RS17850	COG2233	PERMEase
MCHL_RS17865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS17875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS17915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCHL_RS17935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MCHL_RS17945	COG0411	ABC transporter
MCHL_RS17965	COG2205	protein histidine kinase activity
MCHL_RS17965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCHL_RS18015	COG0316	Belongs to the HesB IscA family
MCHL_RS18020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MCHL_RS18055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCHL_RS18060	COG0805	protein transport
MCHL_RS18070	COG2814	Major facilitator Superfamily
MCHL_RS18080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS18085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS18090	COG1116	anion transmembrane transporter activity
MCHL_RS18100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS18105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS18145	COG1309	transcriptional regulator
MCHL_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS18155	COG2814	Major facilitator Superfamily
MCHL_RS18165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MCHL_RS18170	COG1012	belongs to the aldehyde dehydrogenase family
MCHL_RS18185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCHL_RS18195	COG2259	Doxx family
MCHL_RS18200	COG0477	Major facilitator Superfamily
MCHL_RS18210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MCHL_RS18215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MCHL_RS18250	COG1131	(ABC) transporter
MCHL_RS18275	COG2030	dehydratase
MCHL_RS18300	COG0625	glutathione transferase activity
MCHL_RS18335	COG3394	polysaccharide catabolic process
MCHL_RS18365	COG3265	gluconokinase activity
MCHL_RS18380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MCHL_RS18410	COG2309	aminopeptidase activity
MCHL_RS18420	COG0277	FAD linked oxidase domain protein
MCHL_RS18485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS18490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS18585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS18590	COG4566	intracellular signal transduction
MCHL_RS18595	COG4191	Histidine kinase
MCHL_RS18765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MCHL_RS18825	COG4974	Belongs to the 'phage' integrase family
MCHL_RS18915	COG1914	H( )-stimulated, divalent metal cation uptake system
MCHL_RS18975	COG1024	Enoyl-CoA hydratase
MCHL_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS18990	COG0598	Magnesium transport protein CorA
MCHL_RS18995	COG3685	Protein conserved in bacteria
MCHL_RS19030	COG4191	Histidine kinase
MCHL_RS19030	COG0784	Response regulator, receiver
MCHL_RS19055	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MCHL_RS19090	COG4149	molybdate abc transporter
MCHL_RS19100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MCHL_RS19115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCHL_RS19125	COG1215	transferase activity, transferring glycosyl groups
MCHL_RS19135	COG0659	secondary active sulfate transmembrane transporter activity
MCHL_RS19185	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS19210	COG0436	Aminotransferase
MCHL_RS19215	COG1530	ribonuclease E activity
MCHL_RS19215	COG1530	ribonuclease E activity
MCHL_RS19225	COG0860	N-Acetylmuramoyl-L-alanine amidase
MCHL_RS19230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MCHL_RS19245	COG2080	2 iron, 2 sulfur cluster binding
MCHL_RS19250	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MCHL_RS19255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCHL_RS19265	COG2252	PERMEase
MCHL_RS19275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCHL_RS19300	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MCHL_RS19360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MCHL_RS19365	COG2089	acid synthase
MCHL_RS19375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MCHL_RS19385	COG0726	polysaccharide deacetylase
MCHL_RS19385	COG1649	PFAM Uncharacterised BCR, COG1649
MCHL_RS19390	COG1086	Polysaccharide biosynthesis protein
MCHL_RS19395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCHL_RS19415	COG1083	cytidylyl-transferase
MCHL_RS19465	COG1091	dTDP-4-dehydrorhamnose reductase activity
MCHL_RS19470	COG1088	dTDP-glucose 4,6-dehydratase activity
MCHL_RS19475	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MCHL_RS19525	COG4770	biotin carboxylase activity
MCHL_RS19530	COG3665	Urea carboxylase-associated protein
MCHL_RS19535	COG3665	Urea carboxylase-associated protein
MCHL_RS19555	COG1116	anion transmembrane transporter activity
MCHL_RS19560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS19570	COG0517	IMP dehydrogenase activity
MCHL_RS19570	COG4175	Glycine betaine
MCHL_RS19595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCHL_RS19605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MCHL_RS19605	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCHL_RS19615	COG1760	l-serine dehydratase
MCHL_RS19640	COG2181	nitrate reductase activity
MCHL_RS19640	COG0247	lactate metabolic process
MCHL_RS19645	COG1902	pentaerythritol trinitrate reductase activity
MCHL_RS19645	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCHL_RS19650	COG1017	nitric oxide dioxygenase activity
MCHL_RS19650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCHL_RS19655	COG4638	Rieske (2fe-2S)
MCHL_RS19675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCHL_RS19680	COG4172	Belongs to the ABC transporter superfamily
MCHL_RS19685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCHL_RS19690	COG0601	transmembrane transport
MCHL_RS19730	COG1082	Xylose isomerase domain protein TIM barrel
MCHL_RS19780	COG3706	GGDEF domain
MCHL_RS19795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MCHL_RS19815	COG2030	dehydratase
MCHL_RS19860	COG0328	RNA-DNA hybrid ribonuclease activity
MCHL_RS19885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MCHL_RS19975	COG4191	Histidine kinase
MCHL_RS19975	COG0784	Response regulator, receiver
MCHL_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS20005	COG0534	Mate efflux family protein
MCHL_RS20015	COG1309	transcriptional regulator
MCHL_RS20020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCHL_RS20055	COG0583	DNA-binding transcription factor activity
MCHL_RS20110	COG1294	oxidase, subunit
MCHL_RS20115	COG1271	oxidase subunit
MCHL_RS20125	COG0640	Transcriptional regulator
MCHL_RS20135	COG0450	alkyl hydroperoxide reductase
MCHL_RS20150	COG0596	Alpha beta hydrolase
MCHL_RS20155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MCHL_RS20160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCHL_RS20165	COG1120	ATPase activity
MCHL_RS20170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCHL_RS20205	COG0667	Aldo Keto reductase
MCHL_RS20215	COG1335	isochorismatase
MCHL_RS20225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCHL_RS20240	COG0656	L-ascorbic acid biosynthetic process
MCHL_RS20245	COG0742	ribosomal rna small subunit methyltransferase
MCHL_RS20260	COG0431	NADPH-dependent FMN reductase
MCHL_RS20275	COG0798	PFAM Bile acid sodium symporter
MCHL_RS20280	COG5001	Diguanylate cyclase
MCHL_RS20285	COG0596	Alpha beta hydrolase
MCHL_RS20295	COG0590	tRNA wobble adenosine to inosine editing
MCHL_RS20300	COG0151	Belongs to the GarS family
MCHL_RS20315	COG1570	exodeoxyribonuclease VII activity
MCHL_RS20330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCHL_RS20335	COG0604	alcohol dehydrogenase
MCHL_RS20390	COG1053	succinate dehydrogenase
MCHL_RS20405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCHL_RS20425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MCHL_RS20440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MCHL_RS20445	COG0045	succinate-CoA ligase (ADP-forming) activity
MCHL_RS20450	COG1012	belongs to the aldehyde dehydrogenase family
MCHL_RS20455	COG2271	Major facilitator Superfamily
MCHL_RS20480	COG2855	membrane
MCHL_RS20485	COG0028	Belongs to the TPP enzyme family
MCHL_RS20490	COG1414	Transcriptional regulator
MCHL_RS20495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCHL_RS20500	COG2010	Cytochrome c
MCHL_RS20520	COG3181	Tripartite tricarboxylate transporter family receptor
MCHL_RS20525	COG0583	DNA-binding transcription factor activity
MCHL_RS20600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MCHL_RS20655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MCHL_RS20665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCHL_RS20670	COG1595	DNA-templated transcription, initiation
MCHL_RS20735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCHL_RS20755	COG1335	isochorismatase
MCHL_RS20760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MCHL_RS20795	COG3956	TIGRFAM MazG family protein
MCHL_RS20815	COG2301	Belongs to the HpcH HpaI aldolase family
MCHL_RS20825	COG3706	GGDEF domain
MCHL_RS20845	COG2199	diguanylate cyclase activity
MCHL_RS20845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MCHL_RS20870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MCHL_RS20875	COG2226	methyltransferase
MCHL_RS20880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MCHL_RS20885	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS20890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MCHL_RS20900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS20905	COG1999	signal sequence binding
MCHL_RS20915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MCHL_RS20925	COG0359	binds to the 23S rRNA
MCHL_RS20935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MCHL_RS20940	COG0360	Binds together with S18 to 16S ribosomal RNA
MCHL_RS20965	COG1278	Cold shock
MCHL_RS20975	COG0242	peptide deformylase activity
MCHL_RS21005	COG2610	gluconate transmembrane transporter activity
MCHL_RS21010	COG1301	dicarboxylic acid transport
MCHL_RS21020	COG1027	Aspartate ammonia-lyase
MCHL_RS21040	COG0765	amino acid transport
MCHL_RS21045	COG0765	amino acid transport
MCHL_RS21050	COG1126	abc transporter atp-binding protein
MCHL_RS21060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MCHL_RS21105	COG2945	thiolester hydrolase activity
MCHL_RS21115	COG0719	Fe-S assembly protein
MCHL_RS21120	COG0396	ATPase activity
MCHL_RS21125	COG0719	Fe-S assembly protein
MCHL_RS21130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MCHL_RS21145	COG0316	Belongs to the HesB IscA family
MCHL_RS21150	COG5001	Diguanylate cyclase
MCHL_RS21150	COG4251	negative regulation of phosphorylation
MCHL_RS21150	COG3706	GGDEF domain
MCHL_RS21150	COG2203	Gaf domain
MCHL_RS21155	COG0513	Belongs to the DEAD box helicase family
MCHL_RS21165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCHL_RS21205	COG4181	ATPase activity
MCHL_RS21215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MCHL_RS21230	COG0250	Participates in transcription elongation, termination and antitermination
MCHL_RS21235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MCHL_RS21240	COG0081	regulation of translation
MCHL_RS21245	COG2124	cytochrome p450
MCHL_RS21250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCHL_RS21275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MCHL_RS21300	COG5001	Diguanylate cyclase
MCHL_RS21300	COG3300	MHYT domain
MCHL_RS21315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MCHL_RS21320	COG0222	ribosome binding
MCHL_RS21325	COG0085	RNA polymerase activity
MCHL_RS21330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCHL_RS21340	COG0251	oxidation-reduction process
MCHL_RS21345	COG2261	transglycosylase associated protein
MCHL_RS21350	COG0702	epimerase
MCHL_RS21370	COG4774	siderophore transport
MCHL_RS21375	COG1185	polyribonucleotide nucleotidyltransferase activity
MCHL_RS21380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MCHL_RS21385	COG0531	amino acid
MCHL_RS21400	COG5001	Diguanylate cyclase
MCHL_RS21410	COG1674	ftsk spoiiie
MCHL_RS21420	COG0784	Response regulator, receiver
MCHL_RS21430	COG2807	transmembrane transport
MCHL_RS21460	COG0730	response to heat
MCHL_RS21465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MCHL_RS21480	COG1959	2 iron, 2 sulfur cluster binding
MCHL_RS21485	COG3634	alkyl hydroperoxide reductase activity
MCHL_RS21490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MCHL_RS21505	COG3753	Protein conserved in bacteria
MCHL_RS21515	COG0556	nucleotide-excision repair
MCHL_RS21520	COG0583	DNA-binding transcription factor activity
MCHL_RS21530	COG2514	catechol 2,3-dioxygenase activity
MCHL_RS21545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCHL_RS21560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MCHL_RS21600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCHL_RS21605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MCHL_RS21625	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS21635	COG4251	negative regulation of phosphorylation
MCHL_RS21670	COG2204	response regulator
MCHL_RS21675	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MCHL_RS21685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MCHL_RS21690	COG1766	The M ring may be actively involved in energy transduction
MCHL_RS21710	COG0482	sulfurtransferase activity
MCHL_RS21720	COG0398	Pfam SNARE associated Golgi protein
MCHL_RS21730	COG0288	reversible hydration of carbon dioxide
MCHL_RS21750	COG1960	acyl-CoA dehydrogenase activity
MCHL_RS21755	COG0009	L-threonylcarbamoyladenylate synthase
MCHL_RS21765	COG4191	Histidine kinase
MCHL_RS21765	COG0784	Response regulator, receiver
MCHL_RS21770	COG2205	protein histidine kinase activity
MCHL_RS21775	COG4251	negative regulation of phosphorylation
MCHL_RS21780	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MCHL_RS21790	COG4191	Histidine kinase
MCHL_RS21790	COG0784	Response regulator, receiver
MCHL_RS21835	COG4774	siderophore transport
MCHL_RS21855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCHL_RS21875	COG3206	protein involved in exopolysaccharide biosynthesis
MCHL_RS21875	COG0489	protein tyrosine kinase activity
MCHL_RS21885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS21895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS21900	COG1596	polysaccharide export
MCHL_RS21905	COG0662	Cupin 2, conserved barrel domain protein
MCHL_RS21905	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MCHL_RS21960	COG0714	Associated with various cellular activities
MCHL_RS21970	COG2010	Cytochrome c
MCHL_RS21975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCHL_RS21980	COG4993	Dehydrogenase
MCHL_RS22000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCHL_RS22015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCHL_RS22020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCHL_RS22040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MCHL_RS22050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MCHL_RS22055	COG1278	Cold shock
MCHL_RS22085	COG4191	Histidine kinase
MCHL_RS22085	COG0784	Response regulator, receiver
MCHL_RS22090	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS22100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MCHL_RS22105	COG0463	Glycosyl transferase, family 2
MCHL_RS22120	COG2072	flavoprotein involved in K transport
MCHL_RS22135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MCHL_RS22155	COG3920	Histidine kinase
MCHL_RS22175	COG0084	hydrolase, TatD family'
MCHL_RS22200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MCHL_RS22205	COG1177	transmembrane transport
MCHL_RS22210	COG1176	ABC-type spermidine putrescine transport system, permease component I
MCHL_RS22215	COG3842	ATPase activity
MCHL_RS22235	COG2271	Major facilitator Superfamily
MCHL_RS22240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MCHL_RS22250	COG3622	Belongs to the hyi family
MCHL_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS22260	COG0247	lactate metabolic process
MCHL_RS22320	COG0745	RESPONSE REGULATOR receiver
MCHL_RS22340	COG0697	spore germination
MCHL_RS22360	COG1620	l-lactate permease
MCHL_RS22365	COG3546	catalase activity
MCHL_RS22375	COG3737	Protein of unknown function (DUF498/DUF598)
MCHL_RS22385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCHL_RS22390	COG1862	Preprotein translocase
MCHL_RS22405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCHL_RS22410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MCHL_RS22430	COG1846	Transcriptional regulator
MCHL_RS22440	COG1024	Enoyl-CoA hydratase
MCHL_RS22445	COG0113	porphobilinogen synthase activity
MCHL_RS22475	COG0110	maltose O-acetyltransferase activity
MCHL_RS22480	COG2321	neutral zinc metallopeptidase
MCHL_RS22485	COG1573	uracil-dna glycosylase
MCHL_RS22495	COG3191	aminopeptidase activity
MCHL_RS22510	COG0626	cystathionine gamma-synthase activity
MCHL_RS22520	COG0259	pyridoxamine-phosphate oxidase activity
MCHL_RS22530	COG1216	Glycosyl transferase, family 2
MCHL_RS22530	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS22540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCHL_RS22545	COG0071	Belongs to the small heat shock protein (HSP20) family
MCHL_RS22555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MCHL_RS22565	COG0488	(ABC) transporter
MCHL_RS22590	COG4166	transmembrane transport
MCHL_RS22595	COG0601	transmembrane transport
MCHL_RS22600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCHL_RS22610	COG0477	Major facilitator Superfamily
MCHL_RS22630	COG0655	NAD(P)H dehydrogenase (quinone) activity
MCHL_RS22640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MCHL_RS22650	COG1643	Atp-dependent helicase
MCHL_RS22670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MCHL_RS22680	COG2326	polyphosphate kinase activity
MCHL_RS22690	COG2258	MOSC domain
MCHL_RS22695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MCHL_RS22700	COG0484	heat shock protein binding
MCHL_RS22710	COG0259	pyridoxamine-phosphate oxidase activity
MCHL_RS22720	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS22750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MCHL_RS22760	COG2818	Glycosylase
MCHL_RS22765	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MCHL_RS22775	COG1722	exodeoxyribonuclease VII activity
MCHL_RS22780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCHL_RS22785	COG2032	superoxide dismutase activity
MCHL_RS22790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MCHL_RS22795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCHL_RS22820	COG1473	amidohydrolase
MCHL_RS22825	COG2169	Transcriptional regulator
MCHL_RS22825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MCHL_RS22835	COG0537	adenosine 5'-monophosphoramidase activity
MCHL_RS22850	COG3387	PFAM Glycoside hydrolase 15-related
MCHL_RS22860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MCHL_RS22865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCHL_RS22870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MCHL_RS22880	COG0252	asparaginase activity
MCHL_RS22890	COG0398	Pfam SNARE associated Golgi protein
MCHL_RS22905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MCHL_RS22910	COG1845	cytochrome c oxidase, subunit III
MCHL_RS22915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCHL_RS22920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MCHL_RS22925	COG0477	Major facilitator Superfamily
MCHL_RS22930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCHL_RS22940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS22950	COG2197	response regulator
MCHL_RS22960	COG2197	response regulator
MCHL_RS22965	COG2197	response regulator
MCHL_RS23110	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MCHL_RS23110	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MCHL_RS23130	COG4227	nucleotidyltransferase activity
MCHL_RS23140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCHL_RS23165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCHL_RS23250	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCHL_RS23270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCHL_RS23290	COG4191	Histidine kinase
MCHL_RS23290	COG0784	Response regulator, receiver
MCHL_RS23295	COG5001	Diguanylate cyclase
MCHL_RS23295	COG3300	MHYT domain
MCHL_RS23300	COG4974	Belongs to the 'phage' integrase family
MCHL_RS23325	COG1396	sequence-specific DNA binding
MCHL_RS23345	COG5001	Diguanylate cyclase
MCHL_RS23385	COG0745	RESPONSE REGULATOR receiver
MCHL_RS23400	COG4957	zinc ion binding
MCHL_RS23495	COG1396	sequence-specific DNA binding
MCHL_RS23515	COG0154	amidase activity
MCHL_RS23560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS23565	COG1116	anion transmembrane transporter activity
MCHL_RS23580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MCHL_RS23585	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS23605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCHL_RS23645	COG1877	trehalose-phosphatase activity
MCHL_RS23675	COG3383	formate dehydrogenase (NAD+) activity
MCHL_RS23685	COG0583	DNA-binding transcription factor activity
MCHL_RS23695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCHL_RS23710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MCHL_RS23715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MCHL_RS23720	COG0433	COG0433 Predicted ATPase
MCHL_RS23770	COG1597	lipid kinase activity
MCHL_RS23780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCHL_RS23790	COG0784	Response regulator, receiver
MCHL_RS23790	COG5002	protein histidine kinase activity
MCHL_RS23790	COG2205	protein histidine kinase activity
MCHL_RS23800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MCHL_RS23805	COG3178	'Phosphotransferase
MCHL_RS23810	COG2205	protein histidine kinase activity
MCHL_RS23815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MCHL_RS23820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCHL_RS23830	COG1024	Enoyl-CoA hydratase
MCHL_RS23850	COG1074	ATP-dependent DNA helicase activity
MCHL_RS23855	COG2133	pyrroloquinoline quinone binding
MCHL_RS23865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCHL_RS23870	COG0285	dihydrofolate synthase activity
MCHL_RS23885	COG2816	NAD+ diphosphatase activity
MCHL_RS23900	COG0513	Belongs to the DEAD box helicase family
MCHL_RS23920	COG0352	thiamine-phosphate diphosphorylase activity
MCHL_RS23920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MCHL_RS23920	COG0351	phosphomethylpyrimidine kinase
MCHL_RS23925	COG0531	amino acid
MCHL_RS23935	COG3034	peptidoglycan biosynthetic process
MCHL_RS23940	COG4988	ABC transporter
MCHL_RS23955	COG0121	glutamine amidotransferase
MCHL_RS23965	COG4957	zinc ion binding
MCHL_RS23980	COG0633	Ferredoxin
MCHL_RS23995	COG1396	sequence-specific DNA binding
MCHL_RS24000	COG0351	phosphomethylpyrimidine kinase
MCHL_RS24005	COG0352	thiamine-phosphate diphosphorylase activity
MCHL_RS24020	COG4957	zinc ion binding
MCHL_RS24035	COG0725	ABC transporter, periplasmic molybdate-binding protein
MCHL_RS24045	COG2264	protein methyltransferase activity
MCHL_RS24050	COG0006	proline dipeptidase activity
MCHL_RS24050	COG0006	proline dipeptidase activity
MCHL_RS24055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MCHL_RS24060	COG3001	Fructosamine kinase
MCHL_RS24085	COG0625	glutathione transferase activity
MCHL_RS24100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCHL_RS24105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCHL_RS24110	COG1116	anion transmembrane transporter activity
MCHL_RS24115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCHL_RS24120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS24125	COG1116	anion transmembrane transporter activity
MCHL_RS24125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCHL_RS24140	COG3387	PFAM Glycoside hydrolase 15-related
MCHL_RS24150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MCHL_RS24155	COG0586	Pfam SNARE associated Golgi protein
MCHL_RS24185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS24190	COG1054	Belongs to the UPF0176 family
MCHL_RS24195	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS24205	COG3916	Acyl-homoserine-lactone synthase
MCHL_RS24210	COG2197	response regulator
MCHL_RS24320	COG0673	inositol 2-dehydrogenase activity
MCHL_RS24330	COG0583	DNA-binding transcription factor activity
MCHL_RS24335	COG1063	alcohol dehydrogenase
MCHL_RS24340	COG3920	Histidine kinase
MCHL_RS24340	COG2202	Pas domain
MCHL_RS24350	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS24365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCHL_RS24370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCHL_RS24385	COG0628	permease
MCHL_RS24410	COG0071	Belongs to the small heat shock protein (HSP20) family
MCHL_RS24425	COG0483	inositol monophosphate 1-phosphatase activity
MCHL_RS24430	COG0628	permease
MCHL_RS24435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MCHL_RS24445	COG3871	stress protein (general stress protein 26)
MCHL_RS24460	COG0746	molybdenum cofactor guanylyltransferase activity
MCHL_RS24465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCHL_RS24470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCHL_RS24475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MCHL_RS24495	COG0784	Response regulator, receiver
MCHL_RS24495	COG2205	protein histidine kinase activity
MCHL_RS24540	COG3383	formate dehydrogenase (NAD+) activity
MCHL_RS24590	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS24605	COG0657	acetylesterase activity
MCHL_RS24610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MCHL_RS24620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCHL_RS24625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MCHL_RS24650	COG2873	o-acetylhomoserine
MCHL_RS24660	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS24695	COG0457	Tetratricopeptide repeat
MCHL_RS24695	COG0463	Glycosyl transferase, family 2
MCHL_RS24700	COG1032	radical SAM domain protein
MCHL_RS24705	COG1320	monovalent cation:proton antiporter activity
MCHL_RS24710	COG2212	antiporter activity
MCHL_RS24715	COG1863	multisubunit Na H antiporter MnhE subunit
MCHL_RS24720	COG0651	ATP synthesis coupled electron transport
MCHL_RS24725	COG1006	Multisubunit Na H antiporter MnhC subunit
MCHL_RS24730	COG2111	Na H antiporter
MCHL_RS24730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MCHL_RS24740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MCHL_RS24750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCHL_RS24760	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS24785	COG0667	Aldo Keto reductase
MCHL_RS24790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCHL_RS24810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MCHL_RS24820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MCHL_RS24825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MCHL_RS24860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCHL_RS24875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MCHL_RS24880	COG1024	Enoyl-CoA hydratase
MCHL_RS24900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MCHL_RS24925	COG0754	glutathionylspermidine amidase activity
MCHL_RS24935	COG3766	membrane
MCHL_RS24965	COG0149	triose-phosphate isomerase activity
MCHL_RS24975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MCHL_RS24995	COG0134	indole-3-glycerol-phosphate synthase activity
MCHL_RS25000	COG0315	cyclic pyranopterin monophosphate synthase activity
MCHL_RS25005	COG0303	'Molybdopterin
MCHL_RS25020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCHL_RS25025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCHL_RS25035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCHL_RS25040	COG1671	Belongs to the UPF0178 family
MCHL_RS25045	COG0372	Belongs to the citrate synthase family
MCHL_RS25050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCHL_RS25060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MCHL_RS25070	COG0477	Major facilitator Superfamily
MCHL_RS25075	COG3246	L-lysine catabolic process to acetate
MCHL_RS25080	COG0473	3-isopropylmalate dehydrogenase activity
MCHL_RS25090	COG0667	Aldo Keto reductase
MCHL_RS25115	COG0525	valine-tRNA ligase activity
MCHL_RS25130	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCHL_RS25185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MCHL_RS25220	COG0573	inorganic phosphate transmembrane transporter activity
MCHL_RS25225	COG0581	inorganic phosphate transmembrane transporter activity
MCHL_RS25230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MCHL_RS25235	COG0704	Plays a role in the regulation of phosphate uptake
MCHL_RS25240	COG0745	RESPONSE REGULATOR receiver
MCHL_RS25255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCHL_RS25265	COG1492	cobalamin metabolic process
MCHL_RS25270	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MCHL_RS25280	COG2814	Major facilitator Superfamily
MCHL_RS25295	COG3237	CsbD-like
MCHL_RS25300	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS25305	COG0825	malonyl-CoA metabolic process
MCHL_RS25315	COG3034	peptidoglycan biosynthetic process
MCHL_RS25320	COG0335	large ribosomal subunit rRNA binding
MCHL_RS25335	COG2951	lytic endotransglycosylase activity
MCHL_RS25340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MCHL_RS25350	COG1183	phosphatidylcholine synthase activity
MCHL_RS25355	COG0688	phosphatidylethanolamine metabolic process
MCHL_RS25360	COG5265	(ABC) transporter
MCHL_RS25380	COG0215	cysteine-tRNA ligase activity
MCHL_RS25390	COG3045	CreA protein
MCHL_RS25405	COG2814	Major facilitator Superfamily
MCHL_RS25415	COG2226	methyltransferase
MCHL_RS25420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCHL_RS25425	COG1566	PFAM secretion protein HlyD family protein
MCHL_RS25455	COG0625	glutathione transferase activity
MCHL_RS25460	COG0823	Involved in the tonB-independent uptake of proteins
MCHL_RS25470	COG0848	biopolymer transport protein
MCHL_RS25475	COG0811	peptide transport
MCHL_RS25485	COG0824	Thioesterase
MCHL_RS25495	COG1408	metallophosphoesterase
MCHL_RS25500	COG2255	four-way junction helicase activity
MCHL_RS25510	COG0783	Belongs to the Dps family
MCHL_RS25515	COG0045	succinate-CoA ligase (ADP-forming) activity
MCHL_RS25515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCHL_RS25515	COG1042	CoA-binding domain protein
MCHL_RS25520	COG0235	Class ii aldolase
MCHL_RS25525	COG4957	zinc ion binding
MCHL_RS25545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MCHL_RS25555	COG1192	Involved in chromosome partitioning
MCHL_RS25570	COG0459	protein refolding
MCHL_RS25575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MCHL_RS25580	COG0598	Magnesium transport protein CorA
MCHL_RS25585	COG2095	MarC family integral membrane protein
MCHL_RS25595	COG0277	FAD linked oxidase domain protein
MCHL_RS25600	COG0306	phosphate transporter
MCHL_RS25640	COG3739	integral membrane protein
MCHL_RS25650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCHL_RS25655	COG0484	heat shock protein binding
MCHL_RS25660	COG1686	Belongs to the peptidase S11 family
MCHL_RS25665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MCHL_RS25680	COG0156	8-amino-7-oxononanoate synthase activity
MCHL_RS25690	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MCHL_RS25730	COG1429	ligase activity, forming nitrogen-metal bonds
MCHL_RS25735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCHL_RS25740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MCHL_RS25760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MCHL_RS25765	COG2211	Major facilitator Superfamily
MCHL_RS25770	COG0644	oxidoreductase
MCHL_RS25790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MCHL_RS25795	COG0363	glucosamine-6-phosphate deaminase activity
MCHL_RS25805	COG1132	(ABC) transporter
MCHL_RS25810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MCHL_RS25825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MCHL_RS25825	COG3264	Mechanosensitive ion channel
MCHL_RS25855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCHL_RS25865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCHL_RS25870	COG0037	tRNA processing
MCHL_RS25880	COG2885	chlorophyll binding
MCHL_RS25890	COG0745	RESPONSE REGULATOR receiver
MCHL_RS25905	COG0181	hydroxymethylbilane synthase activity
MCHL_RS25915	COG0582	viral genome integration into host DNA
MCHL_RS25930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCHL_RS25980	COG2226	methyltransferase
MCHL_RS26010	COG0582	viral genome integration into host DNA
MCHL_RS26015	COG0405	Gamma-glutamyltransferase
MCHL_RS26025	COG1129	ABC transporter
MCHL_RS26070	COG3685	Protein conserved in bacteria
MCHL_RS26080	COG0028	Belongs to the TPP enzyme family
MCHL_RS26100	COG0367	asparagine synthase
MCHL_RS26130	COG3437	response regulator, receiver
MCHL_RS26145	COG4566	intracellular signal transduction
MCHL_RS26225	COG4191	Histidine kinase
MCHL_RS26225	COG0784	Response regulator, receiver
MCHL_RS26230	COG0318	PFAM AMP-dependent synthetase and ligase
MCHL_RS26285	COG1595	DNA-templated transcription, initiation
MCHL_RS26290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCHL_RS26315	COG2144	transferase activity, transferring acyl groups
MCHL_RS26320	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS26330	COG2072	flavoprotein involved in K transport
MCHL_RS26385	COG1074	ATP-dependent DNA helicase activity
MCHL_RS26510	COG3547	Transposase (IS116 IS110 IS902 family)
MCHL_RS26515	COG3328	transposase activity
MCHL_RS26525	COG3328	transposase activity
MCHL_RS26540	COG3851	Histidine kinase
MCHL_RS26610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MCHL_RS26615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MCHL_RS26620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MCHL_RS26630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCHL_RS26645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCHL_RS26650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCHL_RS26660	COG0589	response to stress
MCHL_RS26675	COG0784	Response regulator, receiver
MCHL_RS26675	COG4191	Histidine kinase
MCHL_RS26695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCHL_RS26735	COG0464	growth
MCHL_RS26750	COG1657	PFAM Prenyltransferase squalene oxidase
MCHL_RS26780	COG5002	protein histidine kinase activity
MCHL_RS26785	COG2204	response regulator
MCHL_RS26790	COG2223	nitrite transmembrane transporter activity
MCHL_RS26845	COG0303	'Molybdopterin
MCHL_RS26850	COG1064	alcohol dehydrogenase
MCHL_RS26855	COG0725	ABC transporter, periplasmic molybdate-binding protein
MCHL_RS26860	COG4149	molybdate abc transporter
MCHL_RS26865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MCHL_RS26870	COG3585	molybdate ion transport
MCHL_RS26885	COG4647	ligase activity
MCHL_RS26890	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
MCHL_RS26895	COG0145	ligase activity
MCHL_RS26935	COG5489	Protein of unknown function (DUF736)
MCHL_RS26950	COG0251	oxidation-reduction process
MCHL_RS26980	COG1819	glycosyl
MCHL_RS27015	COG4423	Transcription factor
MCHL_RS27025	COG5489	Protein of unknown function (DUF736)
MCHL_RS27030	COG0840	transmembrane signaling receptor activity
MCHL_RS27035	COG3328	transposase activity
MCHL_RS27040	COG4227	nucleotidyltransferase activity
MCHL_RS27070	COG1475	DNA binding
MCHL_RS27125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCHL_RS27145	COG2184	nucleotidyltransferase activity
MCHL_RS27325	COG1192	Involved in chromosome partitioning
MCHL_RS27330	COG1475	DNA binding
MCHL_RS27335	COG0640	Transcriptional regulator
MCHL_RS27345	COG1132	(ABC) transporter
MCHL_RS27365	COG1028	Short-chain dehydrogenase reductase Sdr
MCHL_RS27370	COG4584	PFAM Integrase catalytic
MCHL_RS27375	COG1484	DNA-dependent DNA replication
MCHL_RS27420	COG1002	Type II restriction enzyme, methylase subunits
MCHL_RS27530	COG4584	PFAM Integrase catalytic
MCHL_RS27535	COG1484	DNA-dependent DNA replication
MCHL_RS27605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCHL_RS27630	COG2319	Wd-40 repeat
MCHL_RS27640	COG4206	TonB-dependent receptor
MCHL_RS27655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MCHL_RS27730	COG5012	cobalamin binding
MCHL_RS27795	COG4191	Histidine kinase
MCHL_RS27795	COG2205	protein histidine kinase activity
MCHL_RS27795	COG0745	RESPONSE REGULATOR receiver
MCHL_RS27805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCHL_RS27840	COG1492	cobalamin metabolic process
MCHL_RS27845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MCHL_RS27855	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
MCHL_RS27900	COG4680	protein conserved in bacteria
MCHL_RS27985	COG1192	Involved in chromosome partitioning
MCHL_RS28170	COG0072	phenylalanine-tRNA ligase activity
MCHL_RS28170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCHL_RS28275	COG4957	zinc ion binding
MCHL_RS28500	COG3474	cytochrome
MCHL_RS28585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MCHL_RS28950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MCHL_RS28965	COG0860	N-Acetylmuramoyl-L-alanine amidase
MCHL_RS29115	COG5487	UPF0391 membrane protein
MCHL_RS29165	COG4957	zinc ion binding
MCHL_RS29260	COG4957	zinc ion binding
MCHL_RS29345	COG1216	Glycosyl transferase, family 2
MCHL_RS29345	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS29415	COG3609	addiction module antidote protein, CC2985 family
MCHL_RS29435	COG5487	UPF0391 membrane protein
MCHL_RS29450	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS29480	COG2226	methyltransferase
MCHL_RS29510	COG0438	transferase activity, transferring glycosyl groups
MCHL_RS29700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MCHL_RS29710	COG1187	pseudouridine synthase activity
MCHL_RS29815	COG1228	amidohydrolase
MCHL_RS29825	COG0285	dihydrofolate synthase activity
MCHL_RS29835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCHL_RS29850	COG0840	transmembrane signaling receptor activity
MCHL_RS29870	COG0778	Nitroreductase
MCHL_RS29900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family