locus-tag	class	description
MMOL_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MMOL_RS00025	COG1309	transcriptional regulator
MMOL_RS00030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MMOL_RS00035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MMOL_RS00045	COG0583	DNA-binding transcription factor activity
MMOL_RS00050	COG1028	Short-chain dehydrogenase reductase Sdr
MMOL_RS00055	COG0702	epimerase
MMOL_RS00060	COG1733	regulation of RNA biosynthetic process
MMOL_RS00075	COG0583	DNA-binding transcription factor activity
MMOL_RS00080	COG0501	Belongs to the peptidase M48B family
MMOL_RS00085	COG0861	Integral membrane protein TerC family
MMOL_RS00090	COG3038	cytochrome b561
MMOL_RS00105	COG2153	protein acetylation
MMOL_RS00140	COG1194	a g-specific adenine glycosylase
MMOL_RS00150	COG1968	undecaprenyl-diphosphatase activity
MMOL_RS00160	COG1187	pseudouridine synthase activity
MMOL_RS00175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MMOL_RS00180	COG4221	oxidoreductase activity
MMOL_RS00210	COG3852	Histidine kinase
MMOL_RS00215	COG2204	response regulator
MMOL_RS00220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MMOL_RS00225	COG1538	Outer membrane efflux protein
MMOL_RS00235	COG1519	Transferase
MMOL_RS00250	COG1335	isochorismatase
MMOL_RS00260	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MMOL_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
MMOL_RS00290	COG1902	pentaerythritol trinitrate reductase activity
MMOL_RS00300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MMOL_RS00305	COG1902	pentaerythritol trinitrate reductase activity
MMOL_RS00310	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MMOL_RS00315	COG0446	pyridine nucleotide-disulphide oxidoreductase
MMOL_RS00335	COG1309	transcriptional regulator
MMOL_RS00435	COG4221	oxidoreductase activity
MMOL_RS00445	COG1346	cytolysis
MMOL_RS00450	COG3781	membrane
MMOL_RS00460	COG1335	isochorismatase
MMOL_RS00510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MMOL_RS00520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MMOL_RS00535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MMOL_RS00540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MMOL_RS00565	COG0785	Cytochrome C biogenesis protein
MMOL_RS00580	COG3360	Dodecin
MMOL_RS00585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MMOL_RS00610	COG0515	serine threonine protein kinase
MMOL_RS00610	COG2815	serine threonine protein kinase
MMOL_RS00615	COG4251	negative regulation of phosphorylation
MMOL_RS00620	COG0784	Response regulator, receiver
MMOL_RS00630	COG3300	MHYT domain
MMOL_RS00630	COG5001	Diguanylate cyclase
MMOL_RS00640	COG5001	Diguanylate cyclase
MMOL_RS00640	COG5002	protein histidine kinase activity
MMOL_RS00645	COG3530	Putative quorum-sensing-regulated virulence factor
MMOL_RS00670	COG3145	DNA-N1-methyladenine dioxygenase activity
MMOL_RS00680	COG0009	L-threonylcarbamoyladenylate synthase
MMOL_RS00700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MMOL_RS00705	COG0586	Pfam SNARE associated Golgi protein
MMOL_RS00720	COG2086	electron transfer activity
MMOL_RS00725	COG0583	DNA-binding transcription factor activity
MMOL_RS00735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MMOL_RS00740	COG0583	DNA-binding transcription factor activity
MMOL_RS00745	COG3300	MHYT domain
MMOL_RS00745	COG5001	Diguanylate cyclase
MMOL_RS00755	COG2264	protein methyltransferase activity
MMOL_RS00760	COG0439	Biotin carboxylase
MMOL_RS00765	COG0511	ligase activity, forming carbon-carbon bonds
MMOL_RS00775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MMOL_RS00780	COG4232	protein-disulfide reductase activity
MMOL_RS00795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MMOL_RS00795	COG0543	2 iron, 2 sulfur cluster binding
MMOL_RS00805	COG2959	enzyme of heme biosynthesis
MMOL_RS00810	COG1587	Uroporphyrinogen-III synthase
MMOL_RS00815	COG0181	hydroxymethylbilane synthase activity
MMOL_RS00835	COG0165	Argininosuccinate lyase
MMOL_RS00840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MMOL_RS00850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MMOL_RS00855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MMOL_RS00860	COG0631	protein serine/threonine phosphatase activity
MMOL_RS00865	COG1357	PFAM Pentapeptide repeats (8 copies)
MMOL_RS00865	COG0515	serine threonine protein kinase
MMOL_RS00870	COG1561	YicC-like family, N-terminal region
MMOL_RS00880	COG2308	Evidence 4 Homologs of previously reported genes of
MMOL_RS00900	COG0194	GDP metabolic process
MMOL_RS00905	COG1758	RNA polymerase activity
MMOL_RS00910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MMOL_RS00920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MMOL_RS00925	COG3161	chorismate lyase activity
MMOL_RS00930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MMOL_RS00940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MMOL_RS00945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MMOL_RS00950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MMOL_RS00965	COG0316	Belongs to the HesB IscA family
MMOL_RS00975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MMOL_RS00980	COG0739	heme binding
MMOL_RS00985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MMOL_RS01015	COG2203	Gaf domain
MMOL_RS01015	COG3706	GGDEF domain
MMOL_RS01015	COG4251	negative regulation of phosphorylation
MMOL_RS01015	COG5001	Diguanylate cyclase
MMOL_RS01020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MMOL_RS01025	COG4208	sulfate ABC transporter
MMOL_RS01030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MMOL_RS01035	COG2200	EAL domain
MMOL_RS01040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MMOL_RS01055	COG0779	Required for maturation of 30S ribosomal subunits
MMOL_RS01060	COG0195	Participates in both transcription termination and antitermination
MMOL_RS01060	COG2251	uridine kinase activity
MMOL_RS01065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MMOL_RS01070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MMOL_RS01075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MMOL_RS01080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MMOL_RS01085	COG1185	polyribonucleotide nucleotidyltransferase activity
MMOL_RS01095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MMOL_RS01135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MMOL_RS01140	COG1569	PIN domain
MMOL_RS01145	COG3311	Transcriptional regulator
MMOL_RS01170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MMOL_RS01225	COG2204	response regulator
MMOL_RS01230	COG3409	Peptidoglycan-binding domain 1 protein
MMOL_RS01230	COG3267	Type II secretory pathway component ExeA
MMOL_RS01245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MMOL_RS01250	COG1459	type II secretion system
MMOL_RS01280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MMOL_RS01285	COG0330	HflC and HflK could
MMOL_RS01295	COG0415	Belongs to the DNA photolyase family
MMOL_RS01300	COG1704	LemA family
MMOL_RS01310	COG0525	valine-tRNA ligase activity
MMOL_RS01315	COG0425	Belongs to the sulfur carrier protein TusA family
MMOL_RS01320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MMOL_RS01325	COG1785	Belongs to the alkaline phosphatase family
MMOL_RS01335	COG0789	Transcriptional regulator
MMOL_RS01345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MMOL_RS01350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MMOL_RS01365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MMOL_RS01370	COG1492	cobalamin metabolic process
MMOL_RS01390	COG0778	Nitroreductase
MMOL_RS01410	COG1797	cobyrinic acid a,c-diamide synthase activity
MMOL_RS01425	COG4206	TonB-dependent receptor
MMOL_RS01435	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MMOL_RS01455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MMOL_RS01460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MMOL_RS01465	COG0704	Plays a role in the regulation of phosphate uptake
MMOL_RS01475	COG0037	tRNA processing
MMOL_RS01490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MMOL_RS01495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MMOL_RS01505	COG1333	cytochrome c biogenesis protein
MMOL_RS01510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MMOL_RS01525	COG1127	ABC transporter
MMOL_RS01530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MMOL_RS01535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MMOL_RS01550	COG1131	(ABC) transporter
MMOL_RS01555	COG0842	Transport permease protein
MMOL_RS01560	COG0271	Belongs to the BolA IbaG family
MMOL_RS01565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MMOL_RS01570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MMOL_RS01575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MMOL_RS01580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MMOL_RS01585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MMOL_RS01595	COG0131	Imidazoleglycerol-phosphate dehydratase
MMOL_RS01600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MMOL_RS01605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MMOL_RS01610	COG0107	imidazoleglycerol-phosphate synthase activity
MMOL_RS01615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MMOL_RS01620	COG0140	phosphoribosyl-ATP diphosphatase activity
MMOL_RS01625	COG0537	adenosine 5'-monophosphoramidase activity
MMOL_RS01630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MMOL_RS01635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MMOL_RS01640	COG0805	protein transport
MMOL_RS01645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MMOL_RS01655	COG0723	plastoquinol--plastocyanin reductase activity
MMOL_RS01660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MMOL_RS01665	COG2857	Cytochrome c1
MMOL_RS01670	COG0625	glutathione transferase activity
MMOL_RS01675	COG2969	positive regulation of protein catabolic process
MMOL_RS01700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MMOL_RS01710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MMOL_RS01720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MMOL_RS01725	COG0081	regulation of translation
MMOL_RS01730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MMOL_RS01735	COG0222	ribosome binding
MMOL_RS01740	COG0085	RNA polymerase activity
MMOL_RS01745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MMOL_RS01750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MMOL_RS01755	COG0049	tRNA binding
MMOL_RS01760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MMOL_RS01765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MMOL_RS01770	COG0051	transcription antitermination factor activity, RNA binding
MMOL_RS01775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MMOL_RS01780	COG0088	Forms part of the polypeptide exit tunnel
MMOL_RS01785	COG0089	rRNA binding
MMOL_RS01790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MMOL_RS01795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MMOL_RS01800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MMOL_RS01805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MMOL_RS01810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MMOL_RS01815	COG0255	Belongs to the universal ribosomal protein uL29 family
MMOL_RS01820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MMOL_RS01825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MMOL_RS01830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MMOL_RS01835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MMOL_RS01840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MMOL_RS01845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MMOL_RS01850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MMOL_RS01855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MMOL_RS01860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MMOL_RS01865	COG1841	ribosomal large subunit assembly
MMOL_RS01870	COG0200	Binds to the 23S rRNA
MMOL_RS01875	COG0201	protein transport
MMOL_RS01880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MMOL_RS01885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MMOL_RS01890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MMOL_RS01895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MMOL_RS01900	COG0202	RNA polymerase activity
MMOL_RS01905	COG0203	ribosomal protein L17
MMOL_RS01915	COG2239	Acts as a magnesium transporter
MMOL_RS01920	COG3264	Mechanosensitive ion channel
MMOL_RS01920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MMOL_RS01930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MMOL_RS01940	COG4772	TonB-dependent receptor
MMOL_RS01955	COG2003	Belongs to the UPF0758 family
MMOL_RS01965	COG1966	Carbon starvation protein
MMOL_RS01975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MMOL_RS02025	COG0129	dihydroxy-acid dehydratase activity
MMOL_RS02030	COG0676	glucose-6-phosphate 1-epimerase activity
MMOL_RS02035	COG4654	Cytochrome c, class I
MMOL_RS02040	COG0531	amino acid
MMOL_RS02045	COG1362	aminopeptidase activity
MMOL_RS02050	COG0408	coproporphyrinogen oxidase activity
MMOL_RS02055	COG0151	Belongs to the GarS family
MMOL_RS02060	COG0138	bifunctional purine biosynthesis protein purh
MMOL_RS02075	COG0477	Major facilitator Superfamily
MMOL_RS02080	COG1546	Belongs to the CinA family
MMOL_RS02080	COG1058	Belongs to the CinA family
MMOL_RS02085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MMOL_RS02085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MMOL_RS02100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MMOL_RS02110	COG0210	DNA helicase
MMOL_RS02125	COG1741	Belongs to the pirin family
MMOL_RS02130	COG0583	DNA-binding transcription factor activity
MMOL_RS02145	COG0596	Alpha beta hydrolase
MMOL_RS02165	COG0545	Peptidyl-prolyl cis-trans isomerase
MMOL_RS02175	COG0459	protein refolding
MMOL_RS02180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MMOL_RS02185	COG0667	Aldo Keto reductase
MMOL_RS02190	COG2824	Alkylphosphonate utilization operon protein PhnA
MMOL_RS02200	COG0826	peptidase U32
MMOL_RS02210	COG2027	D-alanyl-D-alanine carboxypeptidase
MMOL_RS02220	COG1765	OsmC-like protein
MMOL_RS02235	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MMOL_RS02240	COG0247	lactate metabolic process
MMOL_RS02245	COG0793	Belongs to the peptidase S41A family
MMOL_RS02260	COG0791	NLP P60 protein
MMOL_RS02265	COG1199	ATP-dependent helicase activity
MMOL_RS02280	COG1214	PFAM Peptidase M22, glycoprotease
MMOL_RS02285	COG0456	acetyltransferase
MMOL_RS02295	COG1704	LemA family
MMOL_RS02300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MMOL_RS02315	COG0442	prolyl-tRNA aminoacylation
MMOL_RS02320	COG0741	lytic transglycosylase activity
MMOL_RS02330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MMOL_RS02345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MMOL_RS02360	COG1335	isochorismatase
MMOL_RS02375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MMOL_RS02385	COG0243	molybdopterin cofactor binding
MMOL_RS02390	COG0840	transmembrane signaling receptor activity
MMOL_RS02405	COG2274	protein secretion by the type I secretion system
MMOL_RS02470	COG3245	cytochrome
MMOL_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MMOL_RS02495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MMOL_RS02500	COG1309	transcriptional regulator
MMOL_RS02510	COG1981	membrane
MMOL_RS02535	COG0745	RESPONSE REGULATOR receiver
MMOL_RS02540	COG2223	nitrite transmembrane transporter activity
MMOL_RS02545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MMOL_RS02550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MMOL_RS02555	COG0631	protein serine/threonine phosphatase activity
MMOL_RS02560	COG1716	ATPase activity
MMOL_RS02565	COG3437	response regulator, receiver
MMOL_RS02570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MMOL_RS02580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MMOL_RS02595	COG0215	cysteine-tRNA ligase activity
MMOL_RS02600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MMOL_RS02605	COG0352	thiamine-phosphate diphosphorylase activity
MMOL_RS02615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MMOL_RS02620	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MMOL_RS02625	COG0237	dephospho-CoA kinase activity
MMOL_RS02640	COG0142	geranyltranstransferase activity
MMOL_RS02645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MMOL_RS02650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MMOL_RS02655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MMOL_RS02660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MMOL_RS02665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MMOL_RS02670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MMOL_RS02685	COG0268	Binds directly to 16S ribosomal RNA
MMOL_RS02695	COG0196	riboflavin kinase activity
MMOL_RS02700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MMOL_RS02705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MMOL_RS02715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MMOL_RS02765	COG3278	Belongs to the heme-copper respiratory oxidase family
MMOL_RS02770	COG0109	protoheme IX farnesyltransferase activity
MMOL_RS02775	COG1612	heme a metabolic process
MMOL_RS02795	COG1845	cytochrome c oxidase, subunit III
MMOL_RS02805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MMOL_RS02810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MMOL_RS02830	COG0542	response to heat
MMOL_RS02835	COG0741	lytic transglycosylase activity
MMOL_RS02845	COG0432	Pfam Uncharacterised protein family UPF0047
MMOL_RS02855	COG4942	peptidase
MMOL_RS02860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MMOL_RS02865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MMOL_RS02870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MMOL_RS02875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MMOL_RS02885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MMOL_RS02890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MMOL_RS02900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MMOL_RS02905	COG0156	8-amino-7-oxononanoate synthase activity
MMOL_RS02910	COG2267	carboxylic ester hydrolase activity
MMOL_RS02920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MMOL_RS02930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MMOL_RS02935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MMOL_RS02950	COG0495	leucyl-tRNA aminoacylation
MMOL_RS02955	COG0563	adenylate kinase activity
MMOL_RS02960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MMOL_RS02965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MMOL_RS02970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MMOL_RS02975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MMOL_RS02985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MMOL_RS02990	COG0006	proline dipeptidase activity
MMOL_RS02995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MMOL_RS03000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MMOL_RS03005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MMOL_RS03020	COG1278	Cold shock
MMOL_RS03030	COG1187	pseudouridine synthase activity
MMOL_RS03040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MMOL_RS03050	COG3577	Aspartyl protease
MMOL_RS03055	COG1469	GTP cyclohydrolase I activity
MMOL_RS03060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MMOL_RS03065	COG0142	geranyltranstransferase activity
MMOL_RS03075	COG0400	carboxylic ester hydrolase activity
MMOL_RS03085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MMOL_RS03110	COG0494	nUDIX hydrolase
MMOL_RS03115	COG0688	phosphatidylethanolamine metabolic process
MMOL_RS03120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MMOL_RS03130	COG0028	Belongs to the TPP enzyme family
MMOL_RS03135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MMOL_RS03145	COG0625	glutathione transferase activity
MMOL_RS03155	COG0482	sulfurtransferase activity
MMOL_RS03165	COG2095	MarC family integral membrane protein
MMOL_RS03170	COG0424	maF-like protein
MMOL_RS03185	COG0762	integral membrane protein
MMOL_RS03210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MMOL_RS03215	COG0540	Belongs to the ATCase OTCase family
MMOL_RS03220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MMOL_RS03225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MMOL_RS03230	COG1678	Uncharacterized ACR, COG1678
MMOL_RS03250	COG1136	(ABC) transporter
MMOL_RS03260	COG3437	response regulator, receiver
MMOL_RS03265	COG2205	protein histidine kinase activity
MMOL_RS03265	COG2198	Histidine kinase
MMOL_RS03265	COG0784	Response regulator, receiver
MMOL_RS03270	COG0811	peptide transport
MMOL_RS03275	COG0848	biopolymer transport protein
MMOL_RS03280	COG1132	(ABC) transporter
MMOL_RS03285	COG1663	tetraacyldisaccharide 4'-kinase activity
MMOL_RS03290	COG2835	tetraacyldisaccharide 4'-kinase activity
MMOL_RS03295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MMOL_RS03340	COG0508	dehydrogenase complex catalyzes the overall conversion of
MMOL_RS03350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MMOL_RS03360	COG0277	FAD linked oxidase domain protein
MMOL_RS03370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MMOL_RS03375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MMOL_RS03375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MMOL_RS03380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MMOL_RS03395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MMOL_RS03400	COG0598	Magnesium transport protein CorA
MMOL_RS03405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MMOL_RS03405	COG0047	phosphoribosylformylglycinamidine synthase activity
MMOL_RS03420	COG0446	pyridine nucleotide-disulphide oxidoreductase
MMOL_RS03440	COG2833	Protein of unknown function (DUF455)
MMOL_RS03445	COG0560	Phosphoserine phosphatase
MMOL_RS03450	COG0045	succinate-CoA ligase (ADP-forming) activity
MMOL_RS03455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MMOL_RS03485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MMOL_RS03495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MMOL_RS03505	COG2350	Protein conserved in bacteria
MMOL_RS03510	COG2917	probably involved in intracellular septation
MMOL_RS03515	COG0613	PHP domain protein
MMOL_RS03520	COG0009	L-threonylcarbamoyladenylate synthase
MMOL_RS03525	COG1994	Peptidase M50
MMOL_RS03530	COG0180	Tryptophanyl-tRNA synthetase
MMOL_RS03540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MMOL_RS03550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MMOL_RS03560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MMOL_RS03565	COG1393	Belongs to the ArsC family
MMOL_RS03570	COG2171	N-acyltransferase activity
MMOL_RS03575	COG4783	chaperone-mediated protein folding
MMOL_RS03580	COG3158	transport of potassium into the cell
MMOL_RS03585	COG1570	exodeoxyribonuclease VII activity
MMOL_RS03590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MMOL_RS03615	COG4783	chaperone-mediated protein folding
MMOL_RS03620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MMOL_RS03625	COG3047	cAMP biosynthetic process
MMOL_RS03630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MMOL_RS03635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MMOL_RS03675	COG3278	Belongs to the heme-copper respiratory oxidase family
MMOL_RS03700	COG1472	Belongs to the glycosyl hydrolase 3 family
MMOL_RS03710	COG0590	tRNA wobble adenosine to inosine editing
MMOL_RS03720	COG0583	DNA-binding transcription factor activity
MMOL_RS03725	COG2353	YceI-like domain
MMOL_RS03730	COG1902	pentaerythritol trinitrate reductase activity
MMOL_RS03740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MMOL_RS03755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MMOL_RS03760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MMOL_RS03785	COG0729	surface antigen
MMOL_RS03800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MMOL_RS03805	COG2079	MmgE PrpD family protein
MMOL_RS03815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MMOL_RS03825	COG2030	dehydratase
MMOL_RS03830	COG2301	Belongs to the HpcH HpaI aldolase family
MMOL_RS03835	COG2188	Transcriptional regulator
MMOL_RS03840	COG0281	malic enzyme
MMOL_RS03855	COG1053	succinate dehydrogenase
MMOL_RS03865	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MMOL_RS03890	COG1049	propionate catabolic process, 2-methylcitrate cycle
MMOL_RS03915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MMOL_RS03920	COG1230	cation diffusion facilitator family transporter
MMOL_RS03925	COG1942	4-Oxalocrotonate Tautomerase
MMOL_RS03935	COG0322	excinuclease ABC activity
MMOL_RS03975	COG2197	response regulator
MMOL_RS03980	COG2200	EAL domain
MMOL_RS03995	COG1538	Outer membrane efflux protein
MMOL_RS04010	COG1136	(ABC) transporter
MMOL_RS04010	COG0577	efflux transmembrane transporter activity
MMOL_RS04015	COG1136	(ABC) transporter
MMOL_RS04015	COG0577	efflux transmembrane transporter activity
MMOL_RS04020	COG1136	(ABC) transporter
MMOL_RS04020	COG0577	efflux transmembrane transporter activity
MMOL_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
MMOL_RS04060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MMOL_RS04070	COG1045	serine acetyltransferase
MMOL_RS04075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MMOL_RS04080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MMOL_RS04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MMOL_RS04125	COG0640	Transcriptional regulator
MMOL_RS04135	COG0730	response to heat
MMOL_RS04140	COG3292	Two component regulator propeller
MMOL_RS04140	COG2205	protein histidine kinase activity
MMOL_RS04140	COG0745	RESPONSE REGULATOR receiver
MMOL_RS04145	COG0784	Response regulator, receiver
MMOL_RS04145	COG2198	Histidine kinase
MMOL_RS04145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MMOL_RS04145	COG2205	protein histidine kinase activity
MMOL_RS04155	COG0835	chemotaxis
MMOL_RS04165	COG0745	RESPONSE REGULATOR receiver
MMOL_RS04175	COG0745	RESPONSE REGULATOR receiver
MMOL_RS04180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MMOL_RS04185	COG1530	ribonuclease E activity
MMOL_RS04190	COG0564	pseudouridine synthase activity
MMOL_RS04210	COG2326	polyphosphate kinase activity
MMOL_RS04215	COG0166	Belongs to the GPI family
MMOL_RS04220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MMOL_RS04225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MMOL_RS04240	COG1940	carbohydrate kinase activity
MMOL_RS04255	COG0802	atpase or kinase
MMOL_RS04260	COG0860	N-Acetylmuramoyl-L-alanine amidase
MMOL_RS04265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MMOL_RS04275	COG0840	transmembrane signaling receptor activity
MMOL_RS04280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MMOL_RS04295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MMOL_RS04315	COG0697	spore germination
MMOL_RS04320	COG5001	Diguanylate cyclase
MMOL_RS04320	COG3300	MHYT domain
MMOL_RS04340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MMOL_RS04340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MMOL_RS04345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MMOL_RS04345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MMOL_RS04350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MMOL_RS04355	COG3568	Endonuclease Exonuclease Phosphatase
MMOL_RS04365	COG1054	Belongs to the UPF0176 family
MMOL_RS04375	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MMOL_RS04385	COG1229	Formylmethanofuran dehydrogenase subunit A
MMOL_RS04395	COG0105	UTP biosynthetic process
MMOL_RS04400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MMOL_RS04415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MMOL_RS04420	COG0124	histidyl-tRNA synthetase
MMOL_RS04430	COG4608	Belongs to the ABC transporter superfamily
MMOL_RS04435	COG2976	Protein conserved in bacteria
MMOL_RS04445	COG1160	GTP binding
MMOL_RS04455	COG0840	transmembrane signaling receptor activity
MMOL_RS04470	COG0564	pseudouridine synthase activity
MMOL_RS04485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MMOL_RS04495	COG1309	transcriptional regulator
MMOL_RS04520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MMOL_RS04525	COG1923	regulation of RNA biosynthetic process
MMOL_RS04530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MMOL_RS04535	COG0330	HflC and HflK could
MMOL_RS04540	COG0330	HflC and HflK could
MMOL_RS04545	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MMOL_RS04550	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MMOL_RS04555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MMOL_RS04560	COG0163	prenyltransferase activity
MMOL_RS04575	COG1891	lyase activity
MMOL_RS04585	COG0402	S-adenosylhomocysteine deaminase activity
MMOL_RS04590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MMOL_RS04595	COG0546	phosphoglycolate phosphatase activity
MMOL_RS04600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MMOL_RS04605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MMOL_RS04650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MMOL_RS04650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MMOL_RS04660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MMOL_RS04675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MMOL_RS04705	COG2257	FlhB HrpN YscU SpaS Family
MMOL_RS04710	COG1677	Flagellar hook-basal body complex protein FliE
MMOL_RS04715	COG1766	The M ring may be actively involved in energy transduction
MMOL_RS04740	COG3144	bacterial-type flagellum assembly
MMOL_RS04750	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MMOL_RS04755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MMOL_RS04760	COG3190	flagellar
MMOL_RS04770	COG1987	bacterial-type flagellum assembly
MMOL_RS04780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MMOL_RS04790	COG1705	Flagellar rod assembly protein muramidase FlgJ
MMOL_RS04790	COG3951	Flagellar rod assembly protein muramidase FlgJ
MMOL_RS04795	COG1706	bacterial-type flagellum-dependent cell motility
MMOL_RS04800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MMOL_RS04810	COG4787	bacterial-type flagellum-dependent cell motility
MMOL_RS04820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MMOL_RS04825	COG1558	bacterial-type flagellum-dependent cell motility
MMOL_RS04830	COG1815	bacterial-type flagellum-dependent cell motility
MMOL_RS04850	COG0514	ATP-dependent DNA helicase (RecQ)
MMOL_RS04855	COG0488	(ABC) transporter
MMOL_RS04860	COG0778	Nitroreductase
MMOL_RS04865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MMOL_RS04870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MMOL_RS04870	COG0519	Catalyzes the synthesis of GMP from XMP
MMOL_RS04885	COG2914	Belongs to the UPF0125 (RnfH) family
MMOL_RS04890	COG2867	negative regulation of translational initiation
MMOL_RS04895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MMOL_RS04905	COG0583	DNA-binding transcription factor activity
MMOL_RS04925	COG3123	guanosine phosphorylase activity
MMOL_RS04930	COG1666	GTP binding
MMOL_RS04935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MMOL_RS04945	COG0066	3-isopropylmalate dehydratase activity
MMOL_RS04950	COG0473	3-isopropylmalate dehydrogenase activity
MMOL_RS04970	COG0101	tRNA pseudouridine synthase activity
MMOL_RS04975	COG0135	phosphoribosylanthranilate isomerase activity
MMOL_RS04980	COG0133	tryptophan synthase activity
MMOL_RS04990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MMOL_RS04995	COG0285	dihydrofolate synthase activity
MMOL_RS05005	COG1286	toxin biosynthetic process
MMOL_RS05020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MMOL_RS05020	COG0426	domain, Protein
MMOL_RS05030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MMOL_RS05060	COG0535	radical SAM domain protein
MMOL_RS05065	COG2814	Major facilitator Superfamily
MMOL_RS05070	COG2259	Doxx family
MMOL_RS05075	COG1451	nucleotide metabolic process
MMOL_RS05080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MMOL_RS05085	COG2895	sulfate adenylyltransferase (ATP) activity
MMOL_RS05090	COG0175	sulfate reduction
MMOL_RS05095	COG0175	sulfate reduction
MMOL_RS05105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MMOL_RS05110	COG0730	response to heat
MMOL_RS05115	COG0583	DNA-binding transcription factor activity
MMOL_RS05125	COG0433	COG0433 Predicted ATPase
MMOL_RS05130	COG1739	Uncharacterized protein family UPF0029
MMOL_RS05140	COG2326	polyphosphate kinase activity
MMOL_RS05165	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MMOL_RS05170	COG0314	molybdopterin synthase activity
MMOL_RS05175	COG1067	ATP-dependent peptidase activity
MMOL_RS05180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MMOL_RS05265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MMOL_RS05275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MMOL_RS05290	COG0557	exoribonuclease II activity
MMOL_RS05295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MMOL_RS05300	COG0579	oxidoreductase
MMOL_RS05315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MMOL_RS05330	COG2010	Cytochrome c
MMOL_RS05370	COG2151	metal-sulfur cluster biosynthetic enzyme
MMOL_RS05390	COG1959	2 iron, 2 sulfur cluster binding
MMOL_RS05400	COG2200	EAL domain
MMOL_RS05435	COG1459	type II secretion system
MMOL_RS05440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MMOL_RS05470	COG2165	general secretion pathway protein
MMOL_RS05475	COG4968	Prepilin-type N-terminal cleavage methylation domain
MMOL_RS05500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MMOL_RS05515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MMOL_RS05530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MMOL_RS05540	COG2259	Doxx family
MMOL_RS05560	COG3300	MHYT domain
MMOL_RS05560	COG5001	Diguanylate cyclase
MMOL_RS05570	COG1309	transcriptional regulator
MMOL_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
MMOL_RS05590	COG0604	alcohol dehydrogenase
MMOL_RS05625	COG0714	Associated with various cellular activities
MMOL_RS05645	COG0586	Pfam SNARE associated Golgi protein
MMOL_RS05650	COG2814	Major facilitator Superfamily
MMOL_RS05660	COG2353	YceI-like domain
MMOL_RS05670	COG3038	cytochrome b561
MMOL_RS05675	COG0583	DNA-binding transcription factor activity
MMOL_RS05685	COG2974	May be involved in recombination
MMOL_RS05700	COG2151	metal-sulfur cluster biosynthetic enzyme
MMOL_RS05715	COG0719	Fe-S assembly protein
MMOL_RS05720	COG0396	ATPase activity
MMOL_RS05725	COG0719	Fe-S assembly protein
MMOL_RS05750	COG1234	tRNA 3'-trailer cleavage
MMOL_RS05755	COG0084	hydrolase, TatD family'
MMOL_RS05770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MMOL_RS05775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MMOL_RS05785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MMOL_RS05790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MMOL_RS05805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MMOL_RS05810	COG0416	fatty acid biosynthetic process
MMOL_RS05815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MMOL_RS05820	COG1399	metal-binding, possibly nucleic acid-binding protein
MMOL_RS05825	COG0439	Biotin carboxylase
MMOL_RS05835	COG0424	maF-like protein
MMOL_RS05850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MMOL_RS05855	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MMOL_RS05860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MMOL_RS05865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MMOL_RS05870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MMOL_RS05875	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
MMOL_RS05880	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MMOL_RS05890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MMOL_RS05895	COG0575	Belongs to the CDS family
MMOL_RS05900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MMOL_RS05905	COG0233	cytoplasmic translational termination
MMOL_RS05910	COG0528	UMP kinase activity
MMOL_RS05915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MMOL_RS05920	COG0052	Belongs to the universal ribosomal protein uS2 family
MMOL_RS05930	COG0024	Methionine aminopeptidase
MMOL_RS05935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MMOL_RS05955	COG0242	peptide deformylase activity
MMOL_RS05965	COG1562	ergosterol biosynthetic process
MMOL_RS05985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MMOL_RS05995	COG0359	binds to the 23S rRNA
MMOL_RS06000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MMOL_RS06010	COG0360	Binds together with S18 to 16S ribosomal RNA
MMOL_RS06015	COG0556	nucleotide-excision repair
MMOL_RS06025	COG0436	Aminotransferase
MMOL_RS06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MMOL_RS06060	COG1459	type II secretion system
MMOL_RS06070	COG2165	general secretion pathway protein
MMOL_RS06080	COG4968	Prepilin-type N-terminal cleavage methylation domain
MMOL_RS06135	COG3409	Peptidoglycan-binding domain 1 protein
MMOL_RS06135	COG3267	Type II secretory pathway component ExeA
MMOL_RS06145	COG2217	Heavy metal translocating P-type atpase
MMOL_RS06150	COG2354	Protein conserved in bacteria
MMOL_RS06180	COG1643	Atp-dependent helicase
MMOL_RS06185	COG2202	Pas domain
MMOL_RS06185	COG2205	protein histidine kinase activity
MMOL_RS06215	COG2202	Pas domain
MMOL_RS06215	COG2205	protein histidine kinase activity
MMOL_RS06275	COG0210	DNA helicase
MMOL_RS06280	COG0488	(ABC) transporter
MMOL_RS06315	COG0463	Glycosyl transferase, family 2
MMOL_RS06335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MMOL_RS06345	COG0745	RESPONSE REGULATOR receiver
MMOL_RS06350	COG2201	protein-glutamate methylesterase activity
MMOL_RS06355	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MMOL_RS06360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MMOL_RS06365	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MMOL_RS06370	COG0840	transmembrane signaling receptor activity
MMOL_RS06375	COG0840	transmembrane signaling receptor activity
MMOL_RS06390	COG2198	Histidine kinase
MMOL_RS06390	COG0643	Histidine kinase
MMOL_RS06395	COG0745	RESPONSE REGULATOR receiver
MMOL_RS06435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MMOL_RS06455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MMOL_RS06475	COG3212	peptidase
MMOL_RS06480	COG1217	gtp-binding protein TYPA
MMOL_RS06485	COG0513	Belongs to the DEAD box helicase family
MMOL_RS06490	COG0513	Belongs to the DEAD box helicase family
MMOL_RS06495	COG2346	COG2346, Truncated hemoglobins
MMOL_RS06500	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MMOL_RS06515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MMOL_RS06520	COG4181	ATPase activity
MMOL_RS06530	COG0037	tRNA processing
MMOL_RS06535	COG0825	malonyl-CoA metabolic process
MMOL_RS06545	COG2198	Histidine kinase
MMOL_RS06545	COG0784	Response regulator, receiver
MMOL_RS06545	COG0643	Histidine kinase
MMOL_RS06545	COG2198	Histidine kinase
MMOL_RS06545	COG0784	Response regulator, receiver
MMOL_RS06545	COG0643	Histidine kinase
MMOL_RS06550	COG0840	transmembrane signaling receptor activity
MMOL_RS06585	COG0442	prolyl-tRNA aminoacylation
MMOL_RS06600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MMOL_RS06605	COG0557	exoribonuclease II activity
MMOL_RS06610	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MMOL_RS06620	COG0523	cobalamin synthesis protein
MMOL_RS06625	COG2226	methyltransferase
MMOL_RS06630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MMOL_RS06635	COG0741	lytic transglycosylase activity
MMOL_RS06635	COG1388	LysM domain
MMOL_RS06645	COG0601	transmembrane transport
MMOL_RS06650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MMOL_RS06670	COG4221	oxidoreductase activity
MMOL_RS06675	COG1309	transcriptional regulator
MMOL_RS06680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MMOL_RS06700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MMOL_RS06705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MMOL_RS06710	COG0740	serine-type endopeptidase activity
MMOL_RS06715	COG0544	peptidyl-prolyl cis-trans isomerase activity
MMOL_RS06725	COG3678	ATP-independent chaperone mediated protein folding
MMOL_RS06735	COG0745	RESPONSE REGULATOR receiver
MMOL_RS06740	COG2205	protein histidine kinase activity
MMOL_RS06770	COG2154	pterin-4-alpha-carbinolamine dehydratase
MMOL_RS06780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MMOL_RS06810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MMOL_RS06815	COG2205	protein histidine kinase activity
MMOL_RS06830	COG0189	ligase activity
MMOL_RS06835	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MMOL_RS06845	COG0702	epimerase
MMOL_RS06860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MMOL_RS06870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MMOL_RS06875	COG0297	glycogen (starch) synthase activity
MMOL_RS06880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MMOL_RS06885	COG0501	Belongs to the peptidase M48B family
MMOL_RS06895	COG1162	GTPase activity
MMOL_RS06900	COG0123	including yeast histone deacetylase and acetoin utilization protein
MMOL_RS06910	COG2203	Gaf domain
MMOL_RS06910	COG2200	EAL domain
MMOL_RS06910	COG2199	diguanylate cyclase activity
MMOL_RS06945	COG0328	RNA-DNA hybrid ribonuclease activity
MMOL_RS06950	COG3338	carbonate dehydratase activity
MMOL_RS06955	COG0137	argininosuccinate synthase activity
MMOL_RS06960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MMOL_RS06965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MMOL_RS06980	COG2197	response regulator
MMOL_RS06990	COG1461	Dihydroxyacetone kinase
MMOL_RS06995	COG2376	Dihydroxyacetone kinase
MMOL_RS07005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MMOL_RS07010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MMOL_RS07110	COG4964	Belongs to the GSP D family
MMOL_RS07135	COG4191	Histidine kinase
MMOL_RS07140	COG4566	intracellular signal transduction
MMOL_RS07145	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MMOL_RS07145	COG0778	Nitroreductase
MMOL_RS07160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MMOL_RS07180	COG0488	(ABC) transporter
MMOL_RS07190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MMOL_RS07195	COG0312	modulator of DNA gyrase
MMOL_RS07200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MMOL_RS07210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MMOL_RS07215	COG0686	Belongs to the AlaDH PNT family
MMOL_RS07220	COG1074	ATP-dependent DNA helicase activity
MMOL_RS07250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MMOL_RS07255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MMOL_RS07260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MMOL_RS07270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MMOL_RS07275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MMOL_RS07280	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MMOL_RS07285	COG1674	ftsk spoiiie
MMOL_RS07290	COG0783	Belongs to the Dps family
MMOL_RS07295	COG0492	ferredoxin-NADP+ reductase activity
MMOL_RS07300	COG2840	Smr protein MutS2
MMOL_RS07320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MMOL_RS07335	COG1132	(ABC) transporter
MMOL_RS07340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MMOL_RS07345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MMOL_RS07360	COG2808	Putative FMN-binding domain
MMOL_RS07365	COG0745	RESPONSE REGULATOR receiver
MMOL_RS07370	COG2205	protein histidine kinase activity
MMOL_RS07375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MMOL_RS07380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MMOL_RS07385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MMOL_RS07520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MMOL_RS07545	COG0789	Transcriptional regulator
MMOL_RS07560	COG2217	Heavy metal translocating P-type atpase
MMOL_RS07575	COG0004	ammonium transporteR
MMOL_RS07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MMOL_RS07600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MMOL_RS07605	COG1280	lysine exporter protein (LysE YggA)
MMOL_RS07615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MMOL_RS07620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MMOL_RS07655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MMOL_RS07660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MMOL_RS07665	COG5002	protein histidine kinase activity
MMOL_RS07665	COG5001	Diguanylate cyclase
MMOL_RS07680	COG0287	Prephenate dehydrogenase
MMOL_RS07685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MMOL_RS07690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MMOL_RS07700	COG0776	regulation of translation
MMOL_RS07705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MMOL_RS07710	COG0284	orotidine-5'-phosphate decarboxylase activity
MMOL_RS07715	COG1555	photosystem II stabilization
MMOL_RS07725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MMOL_RS07725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MMOL_RS07730	COG0489	protein tyrosine kinase activity
MMOL_RS07735	COG0363	glucosamine-6-phosphate deaminase activity
MMOL_RS07740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MMOL_RS07745	COG0717	Belongs to the dCTP deaminase family
MMOL_RS07760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MMOL_RS07775	COG0436	Aminotransferase
MMOL_RS07780	COG3737	Protein of unknown function (DUF498/DUF598)
MMOL_RS07785	COG0640	Transcriptional regulator
MMOL_RS07790	COG1902	pentaerythritol trinitrate reductase activity
MMOL_RS07805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MMOL_RS07810	COG0714	Associated with various cellular activities
MMOL_RS07845	COG0354	folic acid binding
MMOL_RS07850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MMOL_RS07855	COG0148	phosphopyruvate hydratase activity
MMOL_RS07860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MMOL_RS07865	COG0504	CTP synthase activity
MMOL_RS07870	COG0235	Class ii aldolase
MMOL_RS07875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MMOL_RS07880	COG0084	hydrolase, TatD family'
MMOL_RS07885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MMOL_RS07885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MMOL_RS07890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MMOL_RS07895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MMOL_RS07900	COG2975	iron-sulfur cluster assembly
MMOL_RS07915	COG0033	Phosphoglucomutase
MMOL_RS07920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MMOL_RS07925	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MMOL_RS07935	COG4654	Cytochrome c, class I
MMOL_RS07945	COG0348	domain, Protein
MMOL_RS07950	COG0437	4 iron, 4 sulfur cluster binding
MMOL_RS07960	COG1858	cytochrome C peroxidase
MMOL_RS07970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MMOL_RS07985	COG0785	Cytochrome C biogenesis protein
MMOL_RS07995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MMOL_RS08005	COG0805	protein transport
MMOL_RS08020	COG0776	regulation of translation
MMOL_RS08025	COG0072	phenylalanine-tRNA ligase activity
MMOL_RS08025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MMOL_RS08030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MMOL_RS08035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MMOL_RS08040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MMOL_RS08045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MMOL_RS08050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MMOL_RS08060	COG2951	lytic endotransglycosylase activity
MMOL_RS08070	COG0494	nUDIX hydrolase
MMOL_RS08080	COG1007	ATP synthesis coupled electron transport
MMOL_RS08095	COG0713	ATP synthesis coupled electron transport
MMOL_RS08105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMOL_RS08110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MMOL_RS08125	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MMOL_RS08130	COG0649	NAD binding
MMOL_RS08135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMOL_RS08140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMOL_RS08145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MMOL_RS08160	COG0149	triose-phosphate isomerase activity
MMOL_RS08170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MMOL_RS08190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MMOL_RS08195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MMOL_RS08210	COG0058	SHG alpha-glucan phosphorylase activity
MMOL_RS08215	COG0326	Molecular chaperone. Has ATPase activity
MMOL_RS08245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MMOL_RS08250	COG0149	triose-phosphate isomerase activity
MMOL_RS08255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MMOL_RS08260	COG0736	holo-[acyl-carrier-protein] synthase activity
MMOL_RS08265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MMOL_RS08270	COG1381	Involved in DNA repair and RecF pathway recombination
MMOL_RS08275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MMOL_RS08280	COG0571	ribonuclease III activity
MMOL_RS08295	COG0481	GTPase activity
MMOL_RS08300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MMOL_RS08325	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MMOL_RS08330	COG0513	Belongs to the DEAD box helicase family
MMOL_RS08335	COG1671	Belongs to the UPF0178 family
MMOL_RS08355	COG0243	molybdopterin cofactor binding
MMOL_RS08365	COG2815	serine threonine protein kinase
MMOL_RS08365	COG0515	serine threonine protein kinase
MMOL_RS08370	COG2223	nitrite transmembrane transporter activity
MMOL_RS08375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MMOL_RS08385	COG1116	anion transmembrane transporter activity
MMOL_RS08390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MMOL_RS08395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MMOL_RS08400	COG3707	response regulator
MMOL_RS08405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MMOL_RS08410	COG3300	MHYT domain
MMOL_RS08410	COG5001	Diguanylate cyclase
MMOL_RS08415	COG0840	transmembrane signaling receptor activity
MMOL_RS08440	COG1846	Transcriptional regulator
MMOL_RS08450	COG0483	inositol monophosphate 1-phosphatase activity
MMOL_RS08455	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MMOL_RS08465	COG1045	serine acetyltransferase
MMOL_RS08480	COG1104	cysteine desulfurase activity
MMOL_RS08485	COG0822	iron-sulfur transferase activity
MMOL_RS08500	COG0443	Heat shock 70 kDa protein
MMOL_RS08505	COG0633	Ferredoxin
MMOL_RS08510	COG0288	reversible hydration of carbon dioxide
MMOL_RS08515	COG0659	secondary active sulfate transmembrane transporter activity
MMOL_RS08525	COG2197	response regulator
MMOL_RS08530	COG2205	protein histidine kinase activity
MMOL_RS08530	COG5002	protein histidine kinase activity
MMOL_RS08530	COG0784	Response regulator, receiver
MMOL_RS08545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MMOL_RS08555	COG1392	Phosphate transport regulator
MMOL_RS08560	COG0306	phosphate transporter
MMOL_RS08565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MMOL_RS08570	COG0573	inorganic phosphate transmembrane transporter activity
MMOL_RS08575	COG0581	inorganic phosphate transmembrane transporter activity
MMOL_RS08580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MMOL_RS08585	COG0308	aminopeptidase N
MMOL_RS08600	COG0671	phosphoesterase, PA-phosphatase related
MMOL_RS08605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MMOL_RS08610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MMOL_RS08615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MMOL_RS08620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MMOL_RS08625	COG1534	Rna-binding protein
MMOL_RS08640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MMOL_RS08645	COG0505	Belongs to the CarA family
MMOL_RS08650	COG3647	Membrane
MMOL_RS08655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MMOL_RS08660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MMOL_RS08665	COG0735	belongs to the Fur family
MMOL_RS08670	COG0497	DNA recombination
MMOL_RS08675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MMOL_RS08685	COG1420	regulation of RNA biosynthetic process
MMOL_RS08690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MMOL_RS08695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MMOL_RS08700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MMOL_RS08705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MMOL_RS08705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MMOL_RS08710	COG0859	PFAM glycosyl transferase family 9
MMOL_RS08735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MMOL_RS08740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MMOL_RS08745	COG0800	Aldolase
MMOL_RS08755	COG2192	nodulation
MMOL_RS08790	COG0438	transferase activity, transferring glycosyl groups
MMOL_RS08795	COG0859	PFAM glycosyl transferase family 9
MMOL_RS08800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MMOL_RS08805	COG0443	Heat shock 70 kDa protein
MMOL_RS08810	COG0484	heat shock protein binding
MMOL_RS08820	COG2197	response regulator
MMOL_RS08825	COG4251	negative regulation of phosphorylation
MMOL_RS08830	COG4651	solute:proton antiporter activity
MMOL_RS08830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MMOL_RS08840	COG2827	Endonuclease containing a URI domain
MMOL_RS08850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MMOL_RS08855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MMOL_RS08860	COG0742	ribosomal rna small subunit methyltransferase
MMOL_RS08865	COG0612	Peptidase, M16
MMOL_RS08870	COG0612	Peptidase, M16
MMOL_RS08880	COG2884	Cell division ATP-binding protein ftsE
MMOL_RS08885	COG2177	Part of the ABC transporter FtsEX involved in
MMOL_RS08950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MMOL_RS08955	COG1278	Cold shock
MMOL_RS08965	COG4654	Cytochrome c, class I
MMOL_RS08975	COG3284	Transcriptional regulator
MMOL_RS08980	COG2068	MobA-Related Protein
MMOL_RS08985	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MMOL_RS09010	COG0583	DNA-binding transcription factor activity
MMOL_RS09020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MMOL_RS09020	COG2199	diguanylate cyclase activity
MMOL_RS09030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MMOL_RS09035	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MMOL_RS09035	COG0662	Cupin 2, conserved barrel domain protein
MMOL_RS09055	COG0438	transferase activity, transferring glycosyl groups
MMOL_RS09095	COG3944	biosynthesis protein
MMOL_RS09120	COG2771	luxR family
MMOL_RS09160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MMOL_RS09180	COG1944	ATP diphosphatase activity
MMOL_RS09185	COG1064	alcohol dehydrogenase
MMOL_RS09190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MMOL_RS09195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MMOL_RS09205	COG2226	methyltransferase
MMOL_RS09215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MMOL_RS09230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MMOL_RS09260	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MMOL_RS09265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MMOL_RS09275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MMOL_RS09280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MMOL_RS09285	COG0193	aminoacyl-tRNA hydrolase activity
MMOL_RS09290	COG0012	GTP binding
MMOL_RS09300	COG2201	protein-glutamate methylesterase activity
MMOL_RS09330	COG2801	Transposase and inactivated derivatives
MMOL_RS09345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MMOL_RS09420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MMOL_RS09445	COG1648	precorrin-2 dehydrogenase activity
MMOL_RS09445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MMOL_RS09450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MMOL_RS09455	COG1702	phosphate starvation-inducible protein PhoH
MMOL_RS09465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MMOL_RS09470	COG4535	Mg2 and Co2 transporter CorC
MMOL_RS09480	COG1970	mechanosensitive ion channel activity
MMOL_RS09485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MMOL_RS09490	COG0752	glycyl-tRNA synthetase alpha subunit
MMOL_RS09495	COG0751	glycine-tRNA ligase activity
MMOL_RS09500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MMOL_RS09515	COG1999	signal sequence binding
MMOL_RS09530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MMOL_RS09535	COG2096	Adenosyltransferase
MMOL_RS09545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MMOL_RS09550	COG1428	Deoxynucleoside kinase
MMOL_RS09555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MMOL_RS09560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MMOL_RS09565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MMOL_RS09575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MMOL_RS09585	COG0415	Belongs to the DNA photolyase family
MMOL_RS09595	COG0312	modulator of DNA gyrase
MMOL_RS09600	COG3028	Belongs to the UPF0307 family
MMOL_RS09615	COG0521	Mo-molybdopterin cofactor biosynthetic process
MMOL_RS09625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MMOL_RS09650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MMOL_RS09655	COG0527	aspartate kinase activity
MMOL_RS09705	COG4774	siderophore transport
MMOL_RS09735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MMOL_RS09735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MMOL_RS09740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MMOL_RS09750	COG3706	GGDEF domain
MMOL_RS09755	COG5001	Diguanylate cyclase
MMOL_RS09765	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MMOL_RS09775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MMOL_RS09790	COG0697	spore germination
MMOL_RS09800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MMOL_RS09805	COG1183	phosphatidylcholine synthase activity
MMOL_RS09815	COG0343	queuine tRNA-ribosyltransferase activity
MMOL_RS09820	COG1862	Preprotein translocase
MMOL_RS09825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MMOL_RS09830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MMOL_RS09835	COG4536	flavin adenine dinucleotide binding
MMOL_RS09840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MMOL_RS09845	COG0542	response to heat
MMOL_RS09860	COG0167	dihydroorotate dehydrogenase activity
MMOL_RS09870	COG0243	molybdopterin cofactor binding
MMOL_RS09875	COG2850	peptidyl-arginine hydroxylation
MMOL_RS09900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MMOL_RS09905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MMOL_RS09910	COG4657	Part of a membrane complex involved in electron transport
MMOL_RS09915	COG2878	Part of a membrane complex involved in electron transport
MMOL_RS09920	COG4656	Part of a membrane complex involved in electron transport
MMOL_RS09935	COG4660	Part of a membrane complex involved in electron transport
MMOL_RS09940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MMOL_RS09970	COG3220	belongs to the UPF0276 family
MMOL_RS09985	COG0653	protein targeting
MMOL_RS09990	COG0739	heme binding
MMOL_RS10010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MMOL_RS10020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MMOL_RS10030	COG0126	phosphoglycerate kinase activity
MMOL_RS10035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MMOL_RS10040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MMOL_RS10060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MMOL_RS10070	COG0500	methyltransferase
MMOL_RS10075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MMOL_RS10075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MMOL_RS10085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MMOL_RS10105	COG0617	tRNA 3'-terminal CCA addition
MMOL_RS10115	COG0739	heme binding
MMOL_RS10115	COG1196	nuclear chromosome segregation
MMOL_RS10115	COG0741	lytic transglycosylase activity
MMOL_RS10125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MMOL_RS10140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MMOL_RS10145	COG1181	Belongs to the D-alanine--D-alanine ligase family
MMOL_RS10150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MMOL_RS10155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MMOL_RS10160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MMOL_RS10165	COG0772	Belongs to the SEDS family
MMOL_RS10170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MMOL_RS10175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MMOL_RS10180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MMOL_RS10185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MMOL_RS10195	COG3116	cell division
MMOL_RS10200	COG0275	rRNA processing
MMOL_RS10205	COG2001	Belongs to the MraZ family
MMOL_RS10220	COG4628	conserved protein (DUF2132)
MMOL_RS10225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MMOL_RS10230	COG0583	DNA-binding transcription factor activity
MMOL_RS10235	COG0418	dihydroorotase activity
MMOL_RS10240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MMOL_RS10250	COG0792	nuclease activity
MMOL_RS10255	COG2823	Periplasmic or secreted lipoprotein
MMOL_RS10265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MMOL_RS10280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MMOL_RS10285	COG0254	rRNA binding
MMOL_RS10300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MMOL_RS10305	COG3383	formate dehydrogenase (NAD+) activity
MMOL_RS10320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MMOL_RS10325	COG0746	molybdenum cofactor guanylyltransferase activity
MMOL_RS10335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MMOL_RS10340	COG4191	Histidine kinase
MMOL_RS10345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MMOL_RS10350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MMOL_RS10360	COG1252	NADH dehydrogenase
MMOL_RS10390	COG1295	ribonuclease BN
MMOL_RS10410	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MMOL_RS10450	COG1610	YqeY-like protein
MMOL_RS10455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MMOL_RS10460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MMOL_RS10465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MMOL_RS10470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MMOL_RS10475	COG4974	Belongs to the 'phage' integrase family
MMOL_RS10485	COG0335	large ribosomal subunit rRNA binding
MMOL_RS10490	COG0336	Belongs to the RNA methyltransferase TrmD family
MMOL_RS10495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MMOL_RS10500	COG0228	four-way junction DNA binding
MMOL_RS10505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MMOL_RS10510	COG0602	queuosine metabolic process
MMOL_RS10525	COG0823	Involved in the tonB-independent uptake of proteins
MMOL_RS10545	COG0824	Thioesterase
MMOL_RS10550	COG2255	four-way junction helicase activity
MMOL_RS10555	COG0628	permease
MMOL_RS10560	COG0632	four-way junction helicase activity
MMOL_RS10565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MMOL_RS10570	COG0217	transcriptional regulatory protein
MMOL_RS10575	COG0697	spore germination
MMOL_RS10585	COG1846	Transcriptional regulator
MMOL_RS10610	COG1304	FMN binding
MMOL_RS10615	COG3128	pkhd-type hydroxylase
MMOL_RS10625	COG4774	siderophore transport
MMOL_RS10635	COG1566	PFAM secretion protein HlyD family protein
MMOL_RS10640	COG1136	(ABC) transporter
MMOL_RS10645	COG0577	efflux transmembrane transporter activity
MMOL_RS10645	COG1136	(ABC) transporter
MMOL_RS10670	COG4256	Hemin uptake protein
MMOL_RS10685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MMOL_RS10700	COG0826	peptidase U32
MMOL_RS10720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MMOL_RS10725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MMOL_RS10740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MMOL_RS10765	COG0725	ABC transporter, periplasmic molybdate-binding protein
MMOL_RS10770	COG4149	molybdate abc transporter
MMOL_RS10775	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MMOL_RS10780	COG0629	single-stranded DNA binding
MMOL_RS10785	COG2814	Major facilitator Superfamily
MMOL_RS10800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MMOL_RS10805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MMOL_RS10815	COG0174	glutamine synthetase
MMOL_RS10825	COG3852	Histidine kinase
MMOL_RS10830	COG2204	response regulator
MMOL_RS10845	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MMOL_RS10850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MMOL_RS10895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MMOL_RS10900	COG0500	methyltransferase
MMOL_RS10905	COG0339	signal peptide processing
MMOL_RS10915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MMOL_RS10920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MMOL_RS10930	COG1660	Displays ATPase and GTPase activities
MMOL_RS10935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MMOL_RS10945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MMOL_RS10950	COG1137	ATPase activity
MMOL_RS10955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MMOL_RS10965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MMOL_RS10985	COG0512	Glutamine amidotransferase of anthranilate synthase
MMOL_RS10990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MMOL_RS11000	COG0134	indole-3-glycerol-phosphate synthase activity
MMOL_RS11015	COG2204	response regulator
MMOL_RS11020	COG5000	phosphorelay sensor kinase activity
MMOL_RS11030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MMOL_RS11040	COG0501	Belongs to the peptidase M48B family
MMOL_RS11045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MMOL_RS11050	COG0242	peptide deformylase activity
MMOL_RS11060	COG0758	DNA mediated transformation
MMOL_RS11065	COG2922	Belongs to the Smg family
MMOL_RS11070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MMOL_RS11080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MMOL_RS11090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MMOL_RS11095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MMOL_RS11105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MMOL_RS11110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MMOL_RS11140	COG0509	glycine decarboxylation via glycine cleavage system
MMOL_RS11155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MMOL_RS11160	COG0795	lipopolysaccharide-transporting ATPase activity
MMOL_RS11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MMOL_RS11225	COG1301	dicarboxylic acid transport
MMOL_RS11230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MMOL_RS11230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MMOL_RS11240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MMOL_RS11245	COG0628	permease
MMOL_RS11250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MMOL_RS11255	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MMOL_RS11265	COG3634	alkyl hydroperoxide reductase activity
MMOL_RS11285	COG4783	chaperone-mediated protein folding
MMOL_RS11290	COG0315	cyclic pyranopterin monophosphate synthase activity
MMOL_RS11300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MMOL_RS11320	COG0546	phosphoglycolate phosphatase activity
MMOL_RS11325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MMOL_RS11330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MMOL_RS11335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MMOL_RS11350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MMOL_RS11355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MMOL_RS11355	COG2813	Specifically methylates the guanine in position
MMOL_RS11360	COG2814	Major facilitator Superfamily
MMOL_RS11365	COG0708	Exodeoxyribonuclease III
MMOL_RS11370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MMOL_RS11380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MMOL_RS11385	COG0154	amidase activity
MMOL_RS11390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MMOL_RS11395	COG1077	Cell shape determining protein MreB Mrl
MMOL_RS11405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MMOL_RS11410	COG0768	penicillin binding
MMOL_RS11415	COG0772	Belongs to the SEDS family
MMOL_RS11425	COG1686	Belongs to the peptidase S11 family
MMOL_RS11430	COG2921	Belongs to the UPF0250 family
MMOL_RS11435	COG0321	lipoyl(octanoyl) transferase activity
MMOL_RS11440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MMOL_RS11450	COG0189	ligase activity
MMOL_RS11515	COG0788	formyltetrahydrofolate deformylase activity
MMOL_RS11520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MMOL_RS11525	COG0494	nUDIX hydrolase
MMOL_RS11530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MMOL_RS11550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MMOL_RS11560	COG0606	chelatase, subunit chli
MMOL_RS11575	COG0347	Belongs to the P(II) protein family
MMOL_RS11580	COG0004	ammonium transporteR
MMOL_RS11620	COG2814	Major facilitator Superfamily
MMOL_RS11625	COG1368	sulfuric ester hydrolase activity
MMOL_RS11635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MMOL_RS11640	COG2967	ApaG domain
MMOL_RS11645	COG2022	thiamine diphosphate biosynthetic process
MMOL_RS11660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MMOL_RS11670	COG0070	glutamate synthase
MMOL_RS11670	COG0069	glutamate synthase activity
MMOL_RS11670	COG0067	glutamate synthase
MMOL_RS11675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MMOL_RS11680	COG0352	thiamine-phosphate diphosphorylase activity
MMOL_RS11685	COG0351	phosphomethylpyrimidine kinase
MMOL_RS11725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MMOL_RS11730	COG0018	arginyl-trna synthetase
MMOL_RS11745	COG0300	oxidoreductase activity
MMOL_RS11750	COG0488	(ABC) transporter
MMOL_RS11755	COG4681	YaeQ
MMOL_RS11765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MMOL_RS11770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MMOL_RS11775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MMOL_RS11780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MMOL_RS11785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MMOL_RS11790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MMOL_RS11795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MMOL_RS11800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MMOL_RS11810	COG0356	it plays a direct role in the translocation of protons across the membrane
MMOL_RS11820	COG1475	DNA binding
MMOL_RS11825	COG1192	Involved in chromosome partitioning
MMOL_RS11830	COG0357	Ribosomal RNA small subunit methyltransferase G
MMOL_RS11835	COG0445	tRNA wobble uridine modification
MMOL_RS11845	COG3422	double-strand break repair
MMOL_RS11850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MMOL_RS11855	COG0706	membrane insertase activity
MMOL_RS11860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MMOL_RS11870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MMOL_RS11890	COG2815	serine threonine protein kinase
MMOL_RS11890	COG0515	serine threonine protein kinase
MMOL_RS11900	COG3447	MASE1 domain protein
MMOL_RS11900	COG5002	protein histidine kinase activity
MMOL_RS11900	COG5001	Diguanylate cyclase
MMOL_RS11905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MMOL_RS11910	COG1215	transferase activity, transferring glycosyl groups
MMOL_RS11915	COG3300	MHYT domain
MMOL_RS11915	COG5001	Diguanylate cyclase
MMOL_RS11930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MMOL_RS11965	COG1022	Amp-dependent synthetase and ligase
MMOL_RS11970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing