locus-tag	class	description
MSIP34_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MSIP34_RS00010	COG0592	DNA-directed DNA polymerase activity
MSIP34_RS00020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSIP34_RS00035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MSIP34_RS00050	COG0579	oxidoreductase
MSIP34_RS00055	COG3250	beta-galactosidase activity
MSIP34_RS00060	COG2814	Major facilitator Superfamily
MSIP34_RS00080	COG3284	Transcriptional regulator
MSIP34_RS00110	COG2264	protein methyltransferase activity
MSIP34_RS00115	COG0439	Biotin carboxylase
MSIP34_RS00120	COG0511	ligase activity, forming carbon-carbon bonds
MSIP34_RS00125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MSIP34_RS00135	COG4232	protein-disulfide reductase activity
MSIP34_RS00150	COG0543	2 iron, 2 sulfur cluster binding
MSIP34_RS00150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MSIP34_RS00160	COG2959	enzyme of heme biosynthesis
MSIP34_RS00165	COG1587	Uroporphyrinogen-III synthase
MSIP34_RS00170	COG0181	hydroxymethylbilane synthase activity
MSIP34_RS00180	COG3275	phosphorelay sensor kinase activity
MSIP34_RS00185	COG0165	Argininosuccinate lyase
MSIP34_RS00195	COG1215	transferase activity, transferring glycosyl groups
MSIP34_RS00210	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MSIP34_RS00215	COG0457	Tetratricopeptide repeat
MSIP34_RS00220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MSIP34_RS00230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MSIP34_RS00235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MSIP34_RS00240	COG0631	protein serine/threonine phosphatase activity
MSIP34_RS00245	COG0515	serine threonine protein kinase
MSIP34_RS00245	COG1357	PFAM Pentapeptide repeats (8 copies)
MSIP34_RS00250	COG1561	YicC-like family, N-terminal region
MSIP34_RS00255	COG0194	GDP metabolic process
MSIP34_RS00260	COG1758	RNA polymerase activity
MSIP34_RS00265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MSIP34_RS00275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSIP34_RS00280	COG3161	chorismate lyase activity
MSIP34_RS00285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MSIP34_RS00290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MSIP34_RS00295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSIP34_RS00300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MSIP34_RS00315	COG0316	Belongs to the HesB IscA family
MSIP34_RS00325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MSIP34_RS00330	COG0739	heme binding
MSIP34_RS00335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MSIP34_RS00365	COG0779	Required for maturation of 30S ribosomal subunits
MSIP34_RS00370	COG0195	Participates in both transcription termination and antitermination
MSIP34_RS00370	COG2251	uridine kinase activity
MSIP34_RS00375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSIP34_RS00380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MSIP34_RS00385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MSIP34_RS00390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MSIP34_RS00395	COG1185	polyribonucleotide nucleotidyltransferase activity
MSIP34_RS00400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MSIP34_RS00405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MSIP34_RS00430	COG2204	response regulator
MSIP34_RS00435	COG3409	Peptidoglycan-binding domain 1 protein
MSIP34_RS00435	COG3267	Type II secretory pathway component ExeA
MSIP34_RS00450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MSIP34_RS00455	COG1459	type II secretion system
MSIP34_RS00485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MSIP34_RS00495	COG0330	HflC and HflK could
MSIP34_RS00505	COG0525	valine-tRNA ligase activity
MSIP34_RS00515	COG0425	Belongs to the sulfur carrier protein TusA family
MSIP34_RS00520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSIP34_RS00525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MSIP34_RS00575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSIP34_RS00610	COG0450	alkyl hydroperoxide reductase
MSIP34_RS00620	COG1132	(ABC) transporter
MSIP34_RS00625	COG1132	(ABC) transporter
MSIP34_RS00630	COG4771	TonB-dependent receptor
MSIP34_RS00655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSIP34_RS00680	COG1216	Glycosyl transferase, family 2
MSIP34_RS00705	COG1083	cytidylyl-transferase
MSIP34_RS00710	COG2089	acid synthase
MSIP34_RS00715	COG1132	(ABC) transporter
MSIP34_RS00725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MSIP34_RS00730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MSIP34_RS00755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSIP34_RS00760	COG1492	cobalamin metabolic process
MSIP34_RS00775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MSIP34_RS00785	COG0778	Nitroreductase
MSIP34_RS00820	COG4206	TonB-dependent receptor
MSIP34_RS00865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MSIP34_RS00870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSIP34_RS00875	COG0704	Plays a role in the regulation of phosphate uptake
MSIP34_RS00880	COG0248	Ppx GppA phosphatase
MSIP34_RS00890	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MSIP34_RS00905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MSIP34_RS00915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MSIP34_RS00925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MSIP34_RS00935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MSIP34_RS00945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MSIP34_RS00950	COG1950	PFAM Membrane protein of
MSIP34_RS00955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MSIP34_RS00960	COG2922	Belongs to the Smg family
MSIP34_RS00965	COG0758	DNA mediated transformation
MSIP34_RS00975	COG0242	peptide deformylase activity
MSIP34_RS00980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MSIP34_RS00985	COG0501	Belongs to the peptidase M48B family
MSIP34_RS00990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MSIP34_RS01000	COG5000	phosphorelay sensor kinase activity
MSIP34_RS01005	COG2204	response regulator
MSIP34_RS01025	COG0339	signal peptide processing
MSIP34_RS01035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MSIP34_RS01050	COG1660	Displays ATPase and GTPase activities
MSIP34_RS01055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MSIP34_RS01065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MSIP34_RS01070	COG1137	ATPase activity
MSIP34_RS01075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MSIP34_RS01085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MSIP34_RS01110	COG0315	cyclic pyranopterin monophosphate synthase activity
MSIP34_RS01140	COG3634	alkyl hydroperoxide reductase activity
MSIP34_RS01155	COG0628	permease
MSIP34_RS01160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MSIP34_RS01175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MSIP34_RS01175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MSIP34_RS01180	COG1301	dicarboxylic acid transport
MSIP34_RS01245	COG0795	lipopolysaccharide-transporting ATPase activity
MSIP34_RS01250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MSIP34_RS01265	COG0509	glycine decarboxylation via glycine cleavage system
MSIP34_RS01280	COG0037	tRNA processing
MSIP34_RS01295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MSIP34_RS01300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MSIP34_RS01310	COG1333	cytochrome c biogenesis protein
MSIP34_RS01315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSIP34_RS01330	COG1127	ABC transporter
MSIP34_RS01335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MSIP34_RS01340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MSIP34_RS01355	COG1131	(ABC) transporter
MSIP34_RS01360	COG0842	Transport permease protein
MSIP34_RS01365	COG0271	Belongs to the BolA IbaG family
MSIP34_RS01370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MSIP34_RS01375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MSIP34_RS01380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MSIP34_RS01385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MSIP34_RS01390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MSIP34_RS01400	COG0131	Imidazoleglycerol-phosphate dehydratase
MSIP34_RS01405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MSIP34_RS01410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSIP34_RS01415	COG0107	imidazoleglycerol-phosphate synthase activity
MSIP34_RS01420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MSIP34_RS01425	COG0140	phosphoribosyl-ATP diphosphatase activity
MSIP34_RS01435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSIP34_RS01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MSIP34_RS01450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSIP34_RS01460	COG0723	plastoquinol--plastocyanin reductase activity
MSIP34_RS01465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MSIP34_RS01470	COG2857	Cytochrome c1
MSIP34_RS01475	COG0625	glutathione transferase activity
MSIP34_RS01480	COG2969	positive regulation of protein catabolic process
MSIP34_RS01505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSIP34_RS01515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MSIP34_RS01525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSIP34_RS01530	COG0081	regulation of translation
MSIP34_RS01535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSIP34_RS01540	COG0222	ribosome binding
MSIP34_RS01545	COG0085	RNA polymerase activity
MSIP34_RS01550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MSIP34_RS01555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MSIP34_RS01560	COG0049	tRNA binding
MSIP34_RS01570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSIP34_RS01575	COG0051	transcription antitermination factor activity, RNA binding
MSIP34_RS01580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSIP34_RS01585	COG0088	Forms part of the polypeptide exit tunnel
MSIP34_RS01590	COG0089	rRNA binding
MSIP34_RS01595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MSIP34_RS01600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MSIP34_RS01605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MSIP34_RS01610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MSIP34_RS01615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MSIP34_RS01620	COG0255	Belongs to the universal ribosomal protein uL29 family
MSIP34_RS01625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MSIP34_RS01630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSIP34_RS01635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MSIP34_RS01640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MSIP34_RS01645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MSIP34_RS01650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MSIP34_RS01655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MSIP34_RS01660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MSIP34_RS01665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSIP34_RS01670	COG1841	ribosomal large subunit assembly
MSIP34_RS01675	COG0200	Binds to the 23S rRNA
MSIP34_RS01680	COG0201	protein transport
MSIP34_RS01685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MSIP34_RS01690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSIP34_RS01695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MSIP34_RS01700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSIP34_RS01705	COG0202	RNA polymerase activity
MSIP34_RS01710	COG0203	ribosomal protein L17
MSIP34_RS01720	COG2239	Acts as a magnesium transporter
MSIP34_RS01725	COG1196	nuclear chromosome segregation
MSIP34_RS01725	COG3264	Mechanosensitive ion channel
MSIP34_RS01735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MSIP34_RS01740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MSIP34_RS01745	COG0756	dUTP diphosphatase activity
MSIP34_RS01760	COG2003	Belongs to the UPF0758 family
MSIP34_RS01785	COG0243	molybdopterin cofactor binding
MSIP34_RS01795	COG0515	serine threonine protein kinase
MSIP34_RS01800	COG2223	nitrite transmembrane transporter activity
MSIP34_RS01805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSIP34_RS01815	COG0840	transmembrane signaling receptor activity
MSIP34_RS01825	COG1116	anion transmembrane transporter activity
MSIP34_RS01830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSIP34_RS01835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MSIP34_RS01840	COG3707	response regulator
MSIP34_RS01850	COG1132	(ABC) transporter
MSIP34_RS01860	COG1966	Carbon starvation protein
MSIP34_RS01900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MSIP34_RS01910	COG0129	dihydroxy-acid dehydratase activity
MSIP34_RS01915	COG0676	glucose-6-phosphate 1-epimerase activity
MSIP34_RS01920	COG4654	Cytochrome c, class I
MSIP34_RS01925	COG0251	oxidation-reduction process
MSIP34_RS01930	COG0531	amino acid
MSIP34_RS01935	COG1115	amino acid carrier protein
MSIP34_RS01940	COG0408	coproporphyrinogen oxidase activity
MSIP34_RS01945	COG0009	L-threonylcarbamoyladenylate synthase
MSIP34_RS01950	COG0151	Belongs to the GarS family
MSIP34_RS01955	COG0138	bifunctional purine biosynthesis protein purh
MSIP34_RS01970	COG0477	Major facilitator Superfamily
MSIP34_RS01980	COG1546	Belongs to the CinA family
MSIP34_RS01980	COG1058	Belongs to the CinA family
MSIP34_RS01990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSIP34_RS01990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MSIP34_RS02005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MSIP34_RS02015	COG0210	DNA helicase
MSIP34_RS02020	COG2885	chlorophyll binding
MSIP34_RS02025	COG2199	diguanylate cyclase activity
MSIP34_RS02035	COG5002	protein histidine kinase activity
MSIP34_RS02060	COG0459	protein refolding
MSIP34_RS02065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MSIP34_RS02095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MSIP34_RS02100	COG0348	domain, Protein
MSIP34_RS02120	COG3852	Histidine kinase
MSIP34_RS02125	COG4774	siderophore transport
MSIP34_RS02180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS02185	COG1136	(ABC) transporter
MSIP34_RS02185	COG0577	efflux transmembrane transporter activity
MSIP34_RS02190	COG1538	Outer membrane efflux protein
MSIP34_RS02205	COG2027	D-alanyl-D-alanine carboxypeptidase
MSIP34_RS02215	COG1765	OsmC-like protein
MSIP34_RS02235	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MSIP34_RS02240	COG0793	Belongs to the peptidase S41A family
MSIP34_RS02255	COG0791	NLP P60 protein
MSIP34_RS02265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MSIP34_RS02270	COG2308	Evidence 4 Homologs of previously reported genes of
MSIP34_RS02280	COG1305	Transglutaminase-like
MSIP34_RS02290	COG0826	peptidase U32
MSIP34_RS02300	COG2001	Belongs to the MraZ family
MSIP34_RS02305	COG0275	rRNA processing
MSIP34_RS02310	COG3116	cell division
MSIP34_RS02320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MSIP34_RS02325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MSIP34_RS02330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MSIP34_RS02335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MSIP34_RS02340	COG0772	Belongs to the SEDS family
MSIP34_RS02345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MSIP34_RS02350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MSIP34_RS02355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MSIP34_RS02360	COG1181	Belongs to the D-alanine--D-alanine ligase family
MSIP34_RS02365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MSIP34_RS02380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MSIP34_RS02390	COG1196	nuclear chromosome segregation
MSIP34_RS02390	COG0741	lytic transglycosylase activity
MSIP34_RS02390	COG0739	heme binding
MSIP34_RS02400	COG0617	tRNA 3'-terminal CCA addition
MSIP34_RS02420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSIP34_RS02425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MSIP34_RS02430	COG0071	Belongs to the small heat shock protein (HSP20) family
MSIP34_RS02435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MSIP34_RS02435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MSIP34_RS02440	COG1914	H( )-stimulated, divalent metal cation uptake system
MSIP34_RS02445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MSIP34_RS02460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MSIP34_RS02465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MSIP34_RS02470	COG0126	phosphoglycerate kinase activity
MSIP34_RS02475	COG0469	pyruvate kinase activity
MSIP34_RS02490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MSIP34_RS02495	COG0288	reversible hydration of carbon dioxide
MSIP34_RS02500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MSIP34_RS02505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MSIP34_RS02515	COG1131	(ABC) transporter
MSIP34_RS02520	COG0730	response to heat
MSIP34_RS02530	COG0739	heme binding
MSIP34_RS02535	COG0653	protein targeting
MSIP34_RS02540	COG0004	ammonium transporteR
MSIP34_RS02555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MSIP34_RS02565	COG0494	nUDIX hydrolase
MSIP34_RS02575	COG2847	Copper chaperone PCu(A)C
MSIP34_RS02580	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MSIP34_RS02585	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MSIP34_RS02590	COG0237	dephospho-CoA kinase activity
MSIP34_RS02605	COG0142	geranyltranstransferase activity
MSIP34_RS02610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MSIP34_RS02615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MSIP34_RS02620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MSIP34_RS02625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MSIP34_RS02630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MSIP34_RS02635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MSIP34_RS02640	COG0268	Binds directly to 16S ribosomal RNA
MSIP34_RS02650	COG0196	riboflavin kinase activity
MSIP34_RS02655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MSIP34_RS02660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MSIP34_RS02665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MSIP34_RS02670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSIP34_RS02675	COG2354	Protein conserved in bacteria
MSIP34_RS02680	COG1064	alcohol dehydrogenase
MSIP34_RS02695	COG0753	catalase activity
MSIP34_RS02705	COG1294	oxidase, subunit
MSIP34_RS02720	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MSIP34_RS02760	COG0542	response to heat
MSIP34_RS02765	COG0702	epimerase
MSIP34_RS02770	COG1733	regulation of RNA biosynthetic process
MSIP34_RS02785	COG0432	Pfam Uncharacterised protein family UPF0047
MSIP34_RS02790	COG1454	alcohol dehydrogenase
MSIP34_RS02800	COG4942	peptidase
MSIP34_RS02805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MSIP34_RS02810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MSIP34_RS02815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MSIP34_RS02820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MSIP34_RS02830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MSIP34_RS02835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MSIP34_RS02855	COG0659	secondary active sulfate transmembrane transporter activity
MSIP34_RS02860	COG1040	competence protein
MSIP34_RS02870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MSIP34_RS02875	COG0156	8-amino-7-oxononanoate synthase activity
MSIP34_RS02880	COG0596	Alpha beta hydrolase
MSIP34_RS02890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MSIP34_RS02900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MSIP34_RS02905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MSIP34_RS02920	COG0495	leucyl-tRNA aminoacylation
MSIP34_RS02925	COG0563	adenylate kinase activity
MSIP34_RS02930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MSIP34_RS02935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MSIP34_RS02940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MSIP34_RS02945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MSIP34_RS02955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MSIP34_RS02960	COG0006	proline dipeptidase activity
MSIP34_RS02965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MSIP34_RS02970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MSIP34_RS02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MSIP34_RS02990	COG1278	Cold shock
MSIP34_RS03000	COG1187	pseudouridine synthase activity
MSIP34_RS03005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSIP34_RS03005	COG0519	Catalyzes the synthesis of GMP from XMP
MSIP34_RS03010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MSIP34_RS03015	COG2211	Major facilitator Superfamily
MSIP34_RS03020	COG3577	Aspartyl protease
MSIP34_RS03025	COG1469	GTP cyclohydrolase I activity
MSIP34_RS03030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MSIP34_RS03035	COG0142	geranyltranstransferase activity
MSIP34_RS03040	COG1722	exodeoxyribonuclease VII activity
MSIP34_RS03050	COG0400	carboxylic ester hydrolase activity
MSIP34_RS03060	COG4969	Belongs to the N-Me-Phe pilin family
MSIP34_RS03070	COG3391	amine dehydrogenase activity
MSIP34_RS03075	COG0494	nUDIX hydrolase
MSIP34_RS03080	COG0688	phosphatidylethanolamine metabolic process
MSIP34_RS03085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MSIP34_RS03090	COG0440	acetolactate synthase activity
MSIP34_RS03095	COG0028	Belongs to the TPP enzyme family
MSIP34_RS03100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MSIP34_RS03110	COG0625	glutathione transferase activity
MSIP34_RS03115	COG0482	sulfurtransferase activity
MSIP34_RS03125	COG2095	MarC family integral membrane protein
MSIP34_RS03135	COG0424	maF-like protein
MSIP34_RS03180	COG0540	Belongs to the ATCase OTCase family
MSIP34_RS03185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MSIP34_RS03190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MSIP34_RS03195	COG1678	Uncharacterized ACR, COG1678
MSIP34_RS03215	COG1136	(ABC) transporter
MSIP34_RS03230	COG0811	peptide transport
MSIP34_RS03235	COG0848	biopolymer transport protein
MSIP34_RS03240	COG1132	(ABC) transporter
MSIP34_RS03245	COG1663	tetraacyldisaccharide 4'-kinase activity
MSIP34_RS03250	COG2835	tetraacyldisaccharide 4'-kinase activity
MSIP34_RS03255	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MSIP34_RS03300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MSIP34_RS03305	COG0598	Magnesium transport protein CorA
MSIP34_RS03310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MSIP34_RS03320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MSIP34_RS03325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MSIP34_RS03330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MSIP34_RS03330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MSIP34_RS03335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MSIP34_RS03355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MSIP34_RS03360	COG0508	dehydrogenase complex catalyzes the overall conversion of
MSIP34_RS03365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MSIP34_RS03370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MSIP34_RS03410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MSIP34_RS03415	COG0149	triose-phosphate isomerase activity
MSIP34_RS03430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSIP34_RS03435	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSIP34_RS03440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSIP34_RS03445	COG0649	NAD binding
MSIP34_RS03450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MSIP34_RS03460	COG1034	ATP synthesis coupled electron transport
MSIP34_RS03465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MSIP34_RS03470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MSIP34_RS03480	COG0713	ATP synthesis coupled electron transport
MSIP34_RS03495	COG1007	ATP synthesis coupled electron transport
MSIP34_RS03515	COG0494	nUDIX hydrolase
MSIP34_RS03595	COG0829	nickel cation binding
MSIP34_RS03600	COG0831	urea catabolic process
MSIP34_RS03605	COG0832	Belongs to the urease beta subunit family
MSIP34_RS03610	COG0804	urea catabolic process
MSIP34_RS03615	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MSIP34_RS03620	COG0830	nickel cation binding
MSIP34_RS03625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MSIP34_RS03635	COG2205	protein histidine kinase activity
MSIP34_RS03635	COG2198	Histidine kinase
MSIP34_RS03635	COG0784	Response regulator, receiver
MSIP34_RS03645	COG0515	serine threonine protein kinase
MSIP34_RS03645	COG2815	serine threonine protein kinase
MSIP34_RS03670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MSIP34_RS03675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MSIP34_RS03680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MSIP34_RS03685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MSIP34_RS03690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MSIP34_RS03695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSIP34_RS03695	COG0072	phenylalanine-tRNA ligase activity
MSIP34_RS03700	COG0776	regulation of translation
MSIP34_RS03715	COG4774	siderophore transport
MSIP34_RS03720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MSIP34_RS03725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MSIP34_RS03730	COG2814	Major facilitator Superfamily
MSIP34_RS03740	COG2197	response regulator
MSIP34_RS03745	COG2197	response regulator
MSIP34_RS03750	COG3851	Histidine kinase
MSIP34_RS03765	COG2010	Cytochrome c
MSIP34_RS03775	COG0714	Associated with various cellular activities
MSIP34_RS03810	COG3851	Histidine kinase
MSIP34_RS03825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MSIP34_RS03835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MSIP34_RS03855	COG2257	FlhB HrpN YscU SpaS Family
MSIP34_RS03860	COG1677	Flagellar hook-basal body complex protein FliE
MSIP34_RS03865	COG1766	The M ring may be actively involved in energy transduction
MSIP34_RS03870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MSIP34_RS03905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MSIP34_RS03920	COG1987	bacterial-type flagellum assembly
MSIP34_RS03945	COG1706	bacterial-type flagellum-dependent cell motility
MSIP34_RS03950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MSIP34_RS03960	COG4787	bacterial-type flagellum-dependent cell motility
MSIP34_RS03970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MSIP34_RS03975	COG1558	bacterial-type flagellum-dependent cell motility
MSIP34_RS03980	COG1815	bacterial-type flagellum-dependent cell motility
MSIP34_RS04000	COG1285	pathogenesis
MSIP34_RS04005	COG0673	inositol 2-dehydrogenase activity
MSIP34_RS04015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MSIP34_RS04020	COG1191	sigma factor activity
MSIP34_RS04035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MSIP34_RS04040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MSIP34_RS04085	COG4774	siderophore transport
MSIP34_RS04095	COG1595	DNA-templated transcription, initiation
MSIP34_RS04110	COG3712	iron ion homeostasis
MSIP34_RS04135	COG0745	RESPONSE REGULATOR receiver
MSIP34_RS04140	COG2198	Histidine kinase
MSIP34_RS04140	COG0643	Histidine kinase
MSIP34_RS04150	COG0840	transmembrane signaling receptor activity
MSIP34_RS04160	COG0840	transmembrane signaling receptor activity
MSIP34_RS04165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MSIP34_RS04170	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSIP34_RS04175	COG2201	protein-glutamate methylesterase activity
MSIP34_RS04180	COG0745	RESPONSE REGULATOR receiver
MSIP34_RS04185	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MSIP34_RS04190	COG2608	mercury ion transmembrane transporter activity
MSIP34_RS04190	COG2217	Heavy metal translocating P-type atpase
MSIP34_RS04200	COG0033	Phosphoglucomutase
MSIP34_RS04210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS04215	COG0438	transferase activity, transferring glycosyl groups
MSIP34_RS04230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MSIP34_RS04235	COG2975	iron-sulfur cluster assembly
MSIP34_RS04250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MSIP34_RS04255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MSIP34_RS04260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MSIP34_RS04260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MSIP34_RS04265	COG0084	hydrolase, TatD family'
MSIP34_RS04280	COG2165	general secretion pathway protein
MSIP34_RS04315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MSIP34_RS04360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MSIP34_RS04365	COG0235	Class ii aldolase
MSIP34_RS04370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MSIP34_RS04370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MSIP34_RS04375	COG0504	CTP synthase activity
MSIP34_RS04380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MSIP34_RS04385	COG0148	phosphopyruvate hydratase activity
MSIP34_RS04390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MSIP34_RS04440	COG0714	Associated with various cellular activities
MSIP34_RS04445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MSIP34_RS04460	COG0436	Aminotransferase
MSIP34_RS04475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MSIP34_RS04500	COG2204	response regulator
MSIP34_RS04510	COG2205	protein histidine kinase activity
MSIP34_RS04515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MSIP34_RS04530	COG0523	cobalamin synthesis protein
MSIP34_RS04535	COG0523	cobalamin synthesis protein
MSIP34_RS04550	COG0557	exoribonuclease II activity
MSIP34_RS04555	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MSIP34_RS04575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MSIP34_RS04575	COG0047	phosphoribosylformylglycinamidine synthase activity
MSIP34_RS04590	COG0446	pyridine nucleotide-disulphide oxidoreductase
MSIP34_RS04595	COG2133	pyrroloquinoline quinone binding
MSIP34_RS04610	COG0560	Phosphoserine phosphatase
MSIP34_RS04615	COG0045	succinate-CoA ligase (ADP-forming) activity
MSIP34_RS04620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MSIP34_RS04645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MSIP34_RS04660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MSIP34_RS04665	COG0271	Belongs to the BolA IbaG family
MSIP34_RS04670	COG2350	Protein conserved in bacteria
MSIP34_RS04675	COG2917	probably involved in intracellular septation
MSIP34_RS04680	COG0613	PHP domain protein
MSIP34_RS04685	COG0009	L-threonylcarbamoyladenylate synthase
MSIP34_RS04690	COG1994	Peptidase M50
MSIP34_RS04695	COG0180	Tryptophanyl-tRNA synthetase
MSIP34_RS04710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSIP34_RS04715	COG1187	pseudouridine synthase activity
MSIP34_RS04740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MSIP34_RS04745	COG1393	Belongs to the ArsC family
MSIP34_RS04750	COG2171	N-acyltransferase activity
MSIP34_RS04755	COG0501	Belongs to the peptidase M48B family
MSIP34_RS04760	COG3158	transport of potassium into the cell
MSIP34_RS04770	COG1570	exodeoxyribonuclease VII activity
MSIP34_RS04775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MSIP34_RS04810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSIP34_RS04815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSIP34_RS04820	COG1116	anion transmembrane transporter activity
MSIP34_RS04830	COG0174	glutamine synthetase
MSIP34_RS04835	COG0864	Transcriptional regulator
MSIP34_RS04845	COG3665	Urea carboxylase-associated protein
MSIP34_RS04850	COG0439	Biotin carboxylase
MSIP34_RS04870	COG0531	amino acid
MSIP34_RS04880	COG4302	ethanolamine ammonia-lyase activity
MSIP34_RS04885	COG0484	heat shock protein binding
MSIP34_RS04890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MSIP34_RS04900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MSIP34_RS04910	COG1335	isochorismatase
MSIP34_RS04930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSIP34_RS04940	COG1472	Belongs to the glycosyl hydrolase 3 family
MSIP34_RS04945	COG0670	Belongs to the BI1 family
MSIP34_RS04965	COG0714	Associated with various cellular activities
MSIP34_RS04975	COG0583	DNA-binding transcription factor activity
MSIP34_RS04980	COG1741	Belongs to the pirin family
MSIP34_RS04990	COG2353	YceI-like domain
MSIP34_RS04995	COG1902	pentaerythritol trinitrate reductase activity
MSIP34_RS05005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MSIP34_RS05015	COG1388	LysM domain
MSIP34_RS05015	COG4942	peptidase
MSIP34_RS05020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSIP34_RS05025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MSIP34_RS05060	COG5001	Diguanylate cyclase
MSIP34_RS05060	COG5002	protein histidine kinase activity
MSIP34_RS05070	COG1049	propionate catabolic process, 2-methylcitrate cycle
MSIP34_RS05090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MSIP34_RS05095	COG2032	superoxide dismutase activity
MSIP34_RS05105	COG1230	cation diffusion facilitator family transporter
MSIP34_RS05115	COG0322	excinuclease ABC activity
MSIP34_RS05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS05170	COG3300	MHYT domain
MSIP34_RS05170	COG5001	Diguanylate cyclase
MSIP34_RS05180	COG1538	Outer membrane efflux protein
MSIP34_RS05200	COG0415	Belongs to the DNA photolyase family
MSIP34_RS05205	COG3046	protein related to deoxyribodipyrimidine photolyase
MSIP34_RS05210	COG2827	Endonuclease containing a URI domain
MSIP34_RS05240	COG1459	type II secretion system
MSIP34_RS05275	COG2165	general secretion pathway protein
MSIP34_RS05290	COG0741	lytic transglycosylase activity
MSIP34_RS05305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSIP34_RS05355	COG4774	siderophore transport
MSIP34_RS05385	COG0488	(ABC) transporter
MSIP34_RS05395	COG0745	RESPONSE REGULATOR receiver
MSIP34_RS05400	COG2205	protein histidine kinase activity
MSIP34_RS05405	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MSIP34_RS05410	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MSIP34_RS05415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MSIP34_RS05425	COG2814	Major facilitator Superfamily
MSIP34_RS05430	COG0210	DNA helicase
MSIP34_RS05435	COG3706	GGDEF domain
MSIP34_RS05450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MSIP34_RS05480	COG1295	ribonuclease BN
MSIP34_RS05500	COG1643	Atp-dependent helicase
MSIP34_RS05505	COG1846	Transcriptional regulator
MSIP34_RS05535	COG0583	DNA-binding transcription factor activity
MSIP34_RS05540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MSIP34_RS05550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MSIP34_RS05550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MSIP34_RS05555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MSIP34_RS05575	COG0717	Belongs to the dCTP deaminase family
MSIP34_RS05580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MSIP34_RS05585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MSIP34_RS05590	COG0363	glucosamine-6-phosphate deaminase activity
MSIP34_RS05600	COG0489	protein tyrosine kinase activity
MSIP34_RS05605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSIP34_RS05605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MSIP34_RS05610	COG1555	photosystem II stabilization
MSIP34_RS05615	COG0284	orotidine-5'-phosphate decarboxylase activity
MSIP34_RS05620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MSIP34_RS05630	COG0776	regulation of translation
MSIP34_RS05640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MSIP34_RS05650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MSIP34_RS05655	COG0287	Prephenate dehydrogenase
MSIP34_RS05660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MSIP34_RS05665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MSIP34_RS05675	COG2199	diguanylate cyclase activity
MSIP34_RS05685	COG1309	transcriptional regulator
MSIP34_RS05720	COG2201	protein-glutamate methylesterase activity
MSIP34_RS05725	COG2197	response regulator
MSIP34_RS05745	COG4585	Histidine kinase
MSIP34_RS05780	COG3040	lipid binding
MSIP34_RS05785	COG1671	Belongs to the UPF0178 family
MSIP34_RS05790	COG0513	Belongs to the DEAD box helicase family
MSIP34_RS05795	COG1187	pseudouridine synthase activity
MSIP34_RS05805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MSIP34_RS05810	COG2376	Dihydroxyacetone kinase
MSIP34_RS05815	COG1461	Dihydroxyacetone kinase
MSIP34_RS05820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MSIP34_RS05830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MSIP34_RS05835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MSIP34_RS05855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MSIP34_RS05855	COG2169	Transcriptional regulator
MSIP34_RS05860	COG0640	Transcriptional regulator
MSIP34_RS05870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MSIP34_RS05875	COG0798	PFAM Bile acid sodium symporter
MSIP34_RS05880	COG0004	ammonium transporteR
MSIP34_RS05895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MSIP34_RS05915	COG2205	protein histidine kinase activity
MSIP34_RS05930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSIP34_RS05940	COG2818	Glycosylase
MSIP34_RS05945	COG0840	transmembrane signaling receptor activity
MSIP34_RS05970	COG2067	long-chain fatty acid transport protein
MSIP34_RS05975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MSIP34_RS05990	COG1012	belongs to the aldehyde dehydrogenase family
MSIP34_RS06005	COG3383	formate dehydrogenase (NAD+) activity
MSIP34_RS06010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MSIP34_RS06020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MSIP34_RS06025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MSIP34_RS06055	COG0492	ferredoxin-NADP+ reductase activity
MSIP34_RS06060	COG0783	Belongs to the Dps family
MSIP34_RS06065	COG1674	ftsk spoiiie
MSIP34_RS06070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MSIP34_RS06075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MSIP34_RS06080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MSIP34_RS06085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSIP34_RS06085	COG4651	solute:proton antiporter activity
MSIP34_RS06090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MSIP34_RS06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSIP34_RS06135	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MSIP34_RS06145	COG1999	signal sequence binding
MSIP34_RS06150	COG0109	protoheme IX farnesyltransferase activity
MSIP34_RS06155	COG1612	heme a metabolic process
MSIP34_RS06175	COG1845	cytochrome c oxidase, subunit III
MSIP34_RS06180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MSIP34_RS06185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MSIP34_RS06205	COG1136	(ABC) transporter
MSIP34_RS06205	COG0577	efflux transmembrane transporter activity
MSIP34_RS06210	COG1136	(ABC) transporter
MSIP34_RS06215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS06225	COG0488	(ABC) transporter
MSIP34_RS06230	COG0778	Nitroreductase
MSIP34_RS06240	COG0519	Catalyzes the synthesis of GMP from XMP
MSIP34_RS06240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MSIP34_RS06255	COG2914	Belongs to the UPF0125 (RnfH) family
MSIP34_RS06260	COG2867	negative regulation of translational initiation
MSIP34_RS06265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MSIP34_RS06290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MSIP34_RS06310	COG1074	ATP-dependent DNA helicase activity
MSIP34_RS06315	COG0586	Pfam SNARE associated Golgi protein
MSIP34_RS06330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MSIP34_RS06345	COG0312	modulator of DNA gyrase
MSIP34_RS06350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MSIP34_RS06360	COG0488	(ABC) transporter
MSIP34_RS06380	COG0745	RESPONSE REGULATOR receiver
MSIP34_RS06385	COG2205	protein histidine kinase activity
MSIP34_RS06390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MSIP34_RS06390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSIP34_RS06430	COG0436	Aminotransferase
MSIP34_RS06435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSIP34_RS06440	COG0556	nucleotide-excision repair
MSIP34_RS06445	COG1530	ribonuclease E activity
MSIP34_RS06470	COG0166	Belongs to the GPI family
MSIP34_RS06475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MSIP34_RS06480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MSIP34_RS06490	COG1449	Belongs to the glycosyl hydrolase 57 family
MSIP34_RS06500	COG3300	MHYT domain
MSIP34_RS06500	COG5001	Diguanylate cyclase
MSIP34_RS06530	COG0463	Glycosyl transferase, family 2
MSIP34_RS06545	COG0802	atpase or kinase
MSIP34_RS06550	COG0860	N-Acetylmuramoyl-L-alanine amidase
MSIP34_RS06555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MSIP34_RS06565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MSIP34_RS06570	COG0352	thiamine-phosphate diphosphorylase activity
MSIP34_RS06570	COG0351	phosphomethylpyrimidine kinase
MSIP34_RS06575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MSIP34_RS06585	COG0697	spore germination
MSIP34_RS06600	COG2200	EAL domain
MSIP34_RS06600	COG2199	diguanylate cyclase activity
MSIP34_RS06610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MSIP34_RS06610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MSIP34_RS06615	COG0500	methyltransferase
MSIP34_RS06620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MSIP34_RS06630	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MSIP34_RS06660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MSIP34_RS06675	COG1595	DNA-templated transcription, initiation
MSIP34_RS06710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MSIP34_RS06725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MSIP34_RS06740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MSIP34_RS06745	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MSIP34_RS06760	COG1742	UPF0060 membrane protein
MSIP34_RS06775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MSIP34_RS06795	COG1063	alcohol dehydrogenase
MSIP34_RS06800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSIP34_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS06865	COG2197	response regulator
MSIP34_RS06890	COG2217	Heavy metal translocating P-type atpase
MSIP34_RS06895	COG1278	Cold shock
MSIP34_RS06955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MSIP34_RS06965	COG1294	oxidase, subunit
MSIP34_RS06970	COG1271	oxidase subunit
MSIP34_RS06985	COG0746	molybdenum cofactor guanylyltransferase activity
MSIP34_RS07005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSIP34_RS07005	COG0321	lipoyl(octanoyl) transferase activity
MSIP34_RS07010	COG0084	hydrolase, TatD family'
MSIP34_RS07020	COG0470	DNA polymerase III
MSIP34_RS07025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSIP34_RS07030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MSIP34_RS07035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MSIP34_RS07040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MSIP34_RS07045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MSIP34_RS07060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MSIP34_RS07065	COG0416	fatty acid biosynthetic process
MSIP34_RS07070	COG1399	metal-binding, possibly nucleic acid-binding protein
MSIP34_RS07075	COG0439	Biotin carboxylase
MSIP34_RS07080	COG5016	pyruvate
MSIP34_RS07080	COG0511	ligase activity, forming carbon-carbon bonds
MSIP34_RS07085	COG0424	maF-like protein
MSIP34_RS07095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MSIP34_RS07100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MSIP34_RS07105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MSIP34_RS07110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MSIP34_RS07115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MSIP34_RS07120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MSIP34_RS07140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MSIP34_RS07145	COG0575	Belongs to the CDS family
MSIP34_RS07150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MSIP34_RS07155	COG0233	cytoplasmic translational termination
MSIP34_RS07160	COG0528	UMP kinase activity
MSIP34_RS07165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MSIP34_RS07170	COG0052	Belongs to the universal ribosomal protein uS2 family
MSIP34_RS07175	COG0024	Methionine aminopeptidase
MSIP34_RS07180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MSIP34_RS07185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSIP34_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS07205	COG0242	peptide deformylase activity
MSIP34_RS07215	COG1562	ergosterol biosynthetic process
MSIP34_RS07230	COG1950	PFAM Membrane protein of
MSIP34_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS07245	COG3647	Membrane
MSIP34_RS07250	COG0546	phosphoglycolate phosphatase activity
MSIP34_RS07260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MSIP34_RS07265	COG0305	Participates in initiation and elongation during chromosome replication
MSIP34_RS07270	COG0626	cystathionine gamma-synthase activity
MSIP34_RS07275	COG0359	binds to the 23S rRNA
MSIP34_RS07280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MSIP34_RS07290	COG0360	Binds together with S18 to 16S ribosomal RNA
MSIP34_RS07305	COG0297	glycogen (starch) synthase activity
MSIP34_RS07310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MSIP34_RS07315	COG0501	Belongs to the peptidase M48B family
MSIP34_RS07325	COG1162	GTPase activity
MSIP34_RS07330	COG0123	including yeast histone deacetylase and acetoin utilization protein
MSIP34_RS07365	COG0328	RNA-DNA hybrid ribonuclease activity
MSIP34_RS07370	COG2226	methyltransferase
MSIP34_RS07375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSIP34_RS07380	COG0741	lytic transglycosylase activity
MSIP34_RS07380	COG1388	LysM domain
MSIP34_RS07385	COG0747	negative chemotaxis
MSIP34_RS07390	COG0601	transmembrane transport
MSIP34_RS07395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MSIP34_RS07405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MSIP34_RS07425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSIP34_RS07430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MSIP34_RS07435	COG0740	serine-type endopeptidase activity
MSIP34_RS07440	COG0544	peptidyl-prolyl cis-trans isomerase activity
MSIP34_RS07450	COG4974	Belongs to the 'phage' integrase family
MSIP34_RS07465	COG2801	Transposase and inactivated derivatives
MSIP34_RS07470	COG2963	transposase activity
MSIP34_RS07550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSIP34_RS07555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MSIP34_RS07585	COG2154	pterin-4-alpha-carbinolamine dehydratase
MSIP34_RS07610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MSIP34_RS07615	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSIP34_RS07620	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MSIP34_RS07635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MSIP34_RS07645	COG1181	Belongs to the D-alanine--D-alanine ligase family
MSIP34_RS07650	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MSIP34_RS07660	COG0702	epimerase
MSIP34_RS07675	COG1229	Formylmethanofuran dehydrogenase subunit A
MSIP34_RS07680	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MSIP34_RS07690	COG2885	chlorophyll binding
MSIP34_RS07695	COG1739	Uncharacterized protein family UPF0029
MSIP34_RS07705	COG0433	COG0433 Predicted ATPase
MSIP34_RS07715	COG0583	DNA-binding transcription factor activity
MSIP34_RS07720	COG0730	response to heat
MSIP34_RS07725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MSIP34_RS07735	COG0175	sulfate reduction
MSIP34_RS07740	COG0175	sulfate reduction
MSIP34_RS07745	COG2895	sulfate adenylyltransferase (ATP) activity
MSIP34_RS07755	COG0514	ATP-dependent DNA helicase (RecQ)
MSIP34_RS07760	COG2814	Major facilitator Superfamily
MSIP34_RS07765	COG0535	radical SAM domain protein
MSIP34_RS07780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MSIP34_RS07785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MSIP34_RS07805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MSIP34_RS07815	COG0450	alkyl hydroperoxide reductase
MSIP34_RS07840	COG1286	toxin biosynthetic process
MSIP34_RS07850	COG0285	dihydrofolate synthase activity
MSIP34_RS07855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MSIP34_RS07860	COG0159	tryptophan synthase activity
MSIP34_RS07865	COG0133	tryptophan synthase activity
MSIP34_RS07870	COG0135	phosphoribosylanthranilate isomerase activity
MSIP34_RS07875	COG0101	tRNA pseudouridine synthase activity
MSIP34_RS07890	COG0473	3-isopropylmalate dehydrogenase activity
MSIP34_RS07895	COG0066	3-isopropylmalate dehydratase activity
MSIP34_RS07905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MSIP34_RS07910	COG1666	GTP binding
MSIP34_RS07920	COG3123	guanosine phosphorylase activity
MSIP34_RS07925	COG0137	argininosuccinate synthase activity
MSIP34_RS07935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MSIP34_RS07940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MSIP34_RS07970	COG2197	response regulator
MSIP34_RS07975	COG3851	Histidine kinase
MSIP34_RS07995	COG0840	transmembrane signaling receptor activity
MSIP34_RS08010	COG0861	Integral membrane protein TerC family
MSIP34_RS08015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MSIP34_RS08020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MSIP34_RS08030	COG4774	siderophore transport
MSIP34_RS08040	COG1595	DNA-templated transcription, initiation
MSIP34_RS08050	COG0640	Transcriptional regulator
MSIP34_RS08055	COG3453	Protein conserved in bacteria
MSIP34_RS08055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSIP34_RS08060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MSIP34_RS08075	COG0745	RESPONSE REGULATOR receiver
MSIP34_RS08110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MSIP34_RS08120	COG0243	molybdopterin cofactor binding
MSIP34_RS08125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MSIP34_RS08150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MSIP34_RS08155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MSIP34_RS08475	COG0582	viral genome integration into host DNA
MSIP34_RS08495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MSIP34_RS08500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MSIP34_RS08510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MSIP34_RS08515	COG0402	S-adenosylhomocysteine deaminase activity
MSIP34_RS08525	COG1891	lyase activity
MSIP34_RS08545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MSIP34_RS08550	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MSIP34_RS08555	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MSIP34_RS08560	COG0330	HflC and HflK could
MSIP34_RS08565	COG0330	HflC and HflK could
MSIP34_RS08570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSIP34_RS08575	COG1923	regulation of RNA biosynthetic process
MSIP34_RS08580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MSIP34_RS08600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS08620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSIP34_RS08645	COG4771	TonB-dependent receptor
MSIP34_RS08650	COG1496	oxidoreductase activity
MSIP34_RS08655	COG0564	pseudouridine synthase activity
MSIP34_RS08665	COG1160	GTP binding
MSIP34_RS08670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MSIP34_RS08675	COG2976	Protein conserved in bacteria
MSIP34_RS08690	COG0124	histidyl-tRNA synthetase
MSIP34_RS08695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MSIP34_RS08710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MSIP34_RS08715	COG0105	UTP biosynthetic process
MSIP34_RS08720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MSIP34_RS08725	COG0557	exoribonuclease II activity
MSIP34_RS08735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MSIP34_RS08760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MSIP34_RS08765	COG1067	ATP-dependent peptidase activity
MSIP34_RS08770	COG0314	molybdopterin synthase activity
MSIP34_RS08775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MSIP34_RS08795	COG4783	chaperone-mediated protein folding
MSIP34_RS08800	COG1217	gtp-binding protein TYPA
MSIP34_RS08805	COG0513	Belongs to the DEAD box helicase family
MSIP34_RS08810	COG0513	Belongs to the DEAD box helicase family
MSIP34_RS08820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MSIP34_RS08825	COG2204	response regulator
MSIP34_RS08830	COG4773	Receptor
MSIP34_RS08835	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MSIP34_RS08840	COG4181	ATPase activity
MSIP34_RS08850	COG0037	tRNA processing
MSIP34_RS08855	COG0825	malonyl-CoA metabolic process
MSIP34_RS08865	COG0643	Histidine kinase
MSIP34_RS08865	COG0784	Response regulator, receiver
MSIP34_RS08865	COG0643	Histidine kinase
MSIP34_RS08865	COG2198	Histidine kinase
MSIP34_RS08865	COG2198	Histidine kinase
MSIP34_RS08865	COG0784	Response regulator, receiver
MSIP34_RS08870	COG0840	transmembrane signaling receptor activity
MSIP34_RS08905	COG0058	SHG alpha-glucan phosphorylase activity
MSIP34_RS08930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MSIP34_RS08945	COG0326	Molecular chaperone. Has ATPase activity
MSIP34_RS08955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSIP34_RS08965	COG4771	TonB-dependent receptor
MSIP34_RS08975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MSIP34_RS08985	COG0736	holo-[acyl-carrier-protein] synthase activity
MSIP34_RS08990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MSIP34_RS08995	COG1381	Involved in DNA repair and RecF pathway recombination
MSIP34_RS09000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MSIP34_RS09005	COG0571	ribonuclease III activity
MSIP34_RS09015	COG0681	Belongs to the peptidase S26 family
MSIP34_RS09020	COG0481	GTPase activity
MSIP34_RS09025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MSIP34_RS09040	COG1595	DNA-templated transcription, initiation
MSIP34_RS09045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MSIP34_RS09060	COG3220	belongs to the UPF0276 family
MSIP34_RS09090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MSIP34_RS09095	COG2878	Part of a membrane complex involved in electron transport
MSIP34_RS09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MSIP34_RS09105	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MSIP34_RS09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MSIP34_RS09130	COG2850	peptidyl-arginine hydroxylation
MSIP34_RS09135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSIP34_RS09155	COG2244	polysaccharide biosynthetic process
MSIP34_RS09180	COG1393	Belongs to the ArsC family
MSIP34_RS09190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MSIP34_RS09195	COG0741	lytic transglycosylase activity
MSIP34_RS09200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MSIP34_RS09205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MSIP34_RS09240	COG0463	Glycosyl transferase, family 2
MSIP34_RS09255	COG1216	Glycosyl transferase, family 2
MSIP34_RS09310	COG2771	luxR family
MSIP34_RS09325	COG0483	inositol monophosphate 1-phosphatase activity
MSIP34_RS09335	COG1045	serine acetyltransferase
MSIP34_RS09345	COG1104	cysteine desulfurase activity
MSIP34_RS09350	COG1104	cysteine desulfurase activity
MSIP34_RS09365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MSIP34_RS09370	COG0443	Heat shock 70 kDa protein
MSIP34_RS09395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MSIP34_RS09400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MSIP34_RS09405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MSIP34_RS09410	COG0573	inorganic phosphate transmembrane transporter activity
MSIP34_RS09415	COG0581	inorganic phosphate transmembrane transporter activity
MSIP34_RS09420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MSIP34_RS09430	COG0297	glycogen (starch) synthase activity
MSIP34_RS09460	COG0671	phosphoesterase, PA-phosphatase related
MSIP34_RS09465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MSIP34_RS09470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MSIP34_RS09475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MSIP34_RS09480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MSIP34_RS09485	COG1534	Rna-binding protein
MSIP34_RS09495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MSIP34_RS09500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MSIP34_RS09505	COG0505	Belongs to the CarA family
MSIP34_RS09510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MSIP34_RS09515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MSIP34_RS09520	COG0735	belongs to the Fur family
MSIP34_RS09525	COG0497	DNA recombination
MSIP34_RS09530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MSIP34_RS09540	COG1420	regulation of RNA biosynthetic process
MSIP34_RS09550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MSIP34_RS09555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MSIP34_RS09560	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MSIP34_RS09565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MSIP34_RS09565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MSIP34_RS09595	COG0800	Aldolase
MSIP34_RS09605	COG2192	nodulation
MSIP34_RS09625	COG0515	serine threonine protein kinase
MSIP34_RS09630	COG0438	transferase activity, transferring glycosyl groups
MSIP34_RS09635	COG0859	PFAM glycosyl transferase family 9
MSIP34_RS09655	COG0859	PFAM glycosyl transferase family 9
MSIP34_RS09685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSIP34_RS09690	COG0657	acetylesterase activity
MSIP34_RS09705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MSIP34_RS09710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MSIP34_RS09715	COG0742	ribosomal rna small subunit methyltransferase
MSIP34_RS09720	COG0612	Peptidase, M16
MSIP34_RS09725	COG0612	Peptidase, M16
MSIP34_RS09735	COG2884	Cell division ATP-binding protein ftsE
MSIP34_RS09740	COG2177	Part of the ABC transporter FtsEX involved in
MSIP34_RS09745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSIP34_RS09745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSIP34_RS09775	COG2824	Alkylphosphonate utilization operon protein PhnA
MSIP34_RS09780	COG0500	methyltransferase
MSIP34_RS09830	COG1172	Belongs to the binding-protein-dependent transport system permease family
MSIP34_RS09845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSIP34_RS09850	COG0431	NADPH-dependent FMN reductase
MSIP34_RS09870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS09890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSIP34_RS09900	COG3829	transcription factor binding
MSIP34_RS09905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MSIP34_RS09915	COG3621	Patatin-like phospholipase
MSIP34_RS09930	COG2807	transmembrane transport
MSIP34_RS09945	COG2194	sulfuric ester hydrolase activity
MSIP34_RS09960	COG2153	protein acetylation
MSIP34_RS09970	COG3008	intermembrane lipid transfer
MSIP34_RS09970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MSIP34_RS09975	COG2995	paraquat-inducible protein a
MSIP34_RS09980	COG2995	paraquat-inducible protein a
MSIP34_RS10065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MSIP34_RS10075	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MSIP34_RS10085	COG2226	methyltransferase
MSIP34_RS10095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MSIP34_RS10110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MSIP34_RS10140	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MSIP34_RS10145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MSIP34_RS10155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MSIP34_RS10160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MSIP34_RS10165	COG0193	aminoacyl-tRNA hydrolase activity
MSIP34_RS10170	COG0012	GTP binding
MSIP34_RS10240	COG1472	Belongs to the glycosyl hydrolase 3 family
MSIP34_RS10515	COG1196	nuclear chromosome segregation
MSIP34_RS10520	COG0583	DNA-binding transcription factor activity
MSIP34_RS10525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MSIP34_RS10530	COG3002	Belongs to the UPF0753 family
MSIP34_RS10595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSIP34_RS10605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MSIP34_RS10635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MSIP34_RS10635	COG1648	precorrin-2 dehydrogenase activity
MSIP34_RS10640	COG3720	iron ion transport
MSIP34_RS10645	COG4558	Periplasmic binding protein
MSIP34_RS10650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MSIP34_RS10655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MSIP34_RS10660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MSIP34_RS10665	COG1702	phosphate starvation-inducible protein PhoH
MSIP34_RS10670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MSIP34_RS10675	COG4535	Mg2 and Co2 transporter CorC
MSIP34_RS10685	COG1970	mechanosensitive ion channel activity
MSIP34_RS10690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MSIP34_RS10695	COG0752	glycyl-tRNA synthetase alpha subunit
MSIP34_RS10700	COG0751	glycine-tRNA ligase activity
MSIP34_RS10705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MSIP34_RS10740	COG2193	ferroxidase activity
MSIP34_RS10745	COG2217	Heavy metal translocating P-type atpase
MSIP34_RS10755	COG0348	domain, Protein
MSIP34_RS10770	COG3278	Belongs to the heme-copper respiratory oxidase family
MSIP34_RS10775	COG3047	cAMP biosynthetic process
MSIP34_RS10785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MSIP34_RS10790	COG2096	Adenosyltransferase
MSIP34_RS10805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MSIP34_RS10815	COG3585	molybdate ion transport
MSIP34_RS10820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MSIP34_RS10825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MSIP34_RS10830	COG1045	serine acetyltransferase
MSIP34_RS10850	COG4208	sulfate ABC transporter
MSIP34_RS10855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MSIP34_RS10865	COG2391	methyltransferase activity
MSIP34_RS10875	COG0617	tRNA 3'-terminal CCA addition
MSIP34_RS10890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MSIP34_RS10895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MSIP34_RS10910	COG3712	iron ion homeostasis
MSIP34_RS10920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MSIP34_RS10930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MSIP34_RS10935	COG0415	Belongs to the DNA photolyase family
MSIP34_RS10940	COG2814	Major facilitator Superfamily
MSIP34_RS10950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MSIP34_RS10955	COG2853	Lipoprotein
MSIP34_RS10960	COG0312	modulator of DNA gyrase
MSIP34_RS10965	COG3028	Belongs to the UPF0307 family
MSIP34_RS10975	COG0750	zinc metalloprotease
MSIP34_RS10980	COG0521	Mo-molybdopterin cofactor biosynthetic process
MSIP34_RS10985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MSIP34_RS10995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MSIP34_RS11000	COG1546	Belongs to the CinA family
MSIP34_RS11010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MSIP34_RS11020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MSIP34_RS11070	COG0840	transmembrane signaling receptor activity
MSIP34_RS11075	COG0281	malic enzyme
MSIP34_RS11105	COG4251	negative regulation of phosphorylation
MSIP34_RS11110	COG0784	Response regulator, receiver
MSIP34_RS11120	COG2133	pyrroloquinoline quinone binding
MSIP34_RS11125	COG0516	GMP reductase activity
MSIP34_RS11130	COG2833	Protein of unknown function (DUF455)
MSIP34_RS11140	COG0778	Nitroreductase
MSIP34_RS11145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MSIP34_RS11180	COG4681	YaeQ
MSIP34_RS11190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MSIP34_RS11195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MSIP34_RS11210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MSIP34_RS11215	COG1183	phosphatidylcholine synthase activity
MSIP34_RS11220	COG0343	queuine tRNA-ribosyltransferase activity
MSIP34_RS11225	COG1862	Preprotein translocase
MSIP34_RS11230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSIP34_RS11235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MSIP34_RS11240	COG4536	flavin adenine dinucleotide binding
MSIP34_RS11245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MSIP34_RS11250	COG0542	response to heat
MSIP34_RS11270	COG0167	dihydroorotate dehydrogenase activity
MSIP34_RS11310	COG0215	cysteine-tRNA ligase activity
MSIP34_RS11330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MSIP34_RS11335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MSIP34_RS11345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MSIP34_RS11350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MSIP34_RS11355	COG2223	nitrite transmembrane transporter activity
MSIP34_RS11375	COG0247	lactate metabolic process
MSIP34_RS11380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MSIP34_RS11385	COG1981	membrane
MSIP34_RS11405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MSIP34_RS11425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MSIP34_RS11430	COG3245	cytochrome
MSIP34_RS11455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MSIP34_RS11465	COG0741	lytic transglycosylase activity
MSIP34_RS11470	COG0442	prolyl-tRNA aminoacylation
MSIP34_RS11495	COG1573	uracil-dna glycosylase
MSIP34_RS11505	COG1214	PFAM Peptidase M22, glycoprotease
MSIP34_RS11520	COG3530	Putative quorum-sensing-regulated virulence factor
MSIP34_RS11535	COG0697	spore germination
MSIP34_RS11560	COG2084	Dehydrogenase
MSIP34_RS11570	COG0583	DNA-binding transcription factor activity
MSIP34_RS11575	COG1199	ATP-dependent helicase activity
MSIP34_RS11595	COG0667	Aldo Keto reductase
MSIP34_RS11620	COG0418	dihydroorotase activity
MSIP34_RS11625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MSIP34_RS11635	COG0792	nuclease activity
MSIP34_RS11640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MSIP34_RS11645	COG2823	Periplasmic or secreted lipoprotein
MSIP34_RS11655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MSIP34_RS11670	COG2200	EAL domain
MSIP34_RS11680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MSIP34_RS11685	COG0254	rRNA binding
MSIP34_RS11695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MSIP34_RS11700	COG4149	molybdate abc transporter
MSIP34_RS11705	COG0725	ABC transporter, periplasmic molybdate-binding protein
MSIP34_RS11715	COG2005	Transcriptional regulator
MSIP34_RS11720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MSIP34_RS11725	COG0746	molybdenum cofactor guanylyltransferase activity
MSIP34_RS11730	COG1763	Mo-molybdopterin cofactor biosynthetic process
MSIP34_RS11745	COG4772	TonB-dependent receptor
MSIP34_RS11755	COG3038	cytochrome b561
MSIP34_RS11770	COG4191	Histidine kinase
MSIP34_RS11775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MSIP34_RS11780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MSIP34_RS11785	COG0477	Major facilitator Superfamily
MSIP34_RS11790	COG1252	NADH dehydrogenase
MSIP34_RS11805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MSIP34_RS11825	COG1054	Belongs to the UPF0176 family
MSIP34_RS11830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MSIP34_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS11860	COG3177	Filamentation induced by cAMP protein fic
MSIP34_RS11980	COG1610	YqeY-like protein
MSIP34_RS11985	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MSIP34_RS11990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MSIP34_RS11995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MSIP34_RS12010	COG3012	SEC-C Motif Domain Protein
MSIP34_RS12015	COG4974	Belongs to the 'phage' integrase family
MSIP34_RS12025	COG0335	large ribosomal subunit rRNA binding
MSIP34_RS12030	COG0336	Belongs to the RNA methyltransferase TrmD family
MSIP34_RS12035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MSIP34_RS12040	COG0228	four-way junction DNA binding
MSIP34_RS12045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MSIP34_RS12050	COG0602	queuosine metabolic process
MSIP34_RS12060	COG2885	chlorophyll binding
MSIP34_RS12065	COG0823	Involved in the tonB-independent uptake of proteins
MSIP34_RS12085	COG0824	Thioesterase
MSIP34_RS12090	COG2255	four-way junction helicase activity
MSIP34_RS12095	COG0632	four-way junction helicase activity
MSIP34_RS12100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MSIP34_RS12105	COG0217	transcriptional regulatory protein
MSIP34_RS12110	COG0697	spore germination
MSIP34_RS12120	COG1846	Transcriptional regulator
MSIP34_RS12125	COG0517	IMP dehydrogenase activity
MSIP34_RS12125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MSIP34_RS12155	COG0505	Belongs to the CarA family
MSIP34_RS12175	COG0069	glutamate synthase activity
MSIP34_RS12185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MSIP34_RS12200	COG0446	pyridine nucleotide-disulphide oxidoreductase
MSIP34_RS12200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MSIP34_RS12220	COG0456	acetyltransferase
MSIP34_RS12225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MSIP34_RS12230	COG1127	ABC transporter
MSIP34_RS12260	COG1597	lipid kinase activity
MSIP34_RS12300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MSIP34_RS12305	COG3568	Endonuclease Exonuclease Phosphatase
MSIP34_RS12310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MSIP34_RS12315	COG0494	nUDIX hydrolase
MSIP34_RS12320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MSIP34_RS12330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MSIP34_RS12360	COG0247	lactate metabolic process
MSIP34_RS12360	COG2181	nitrate reductase activity
MSIP34_RS12385	COG2197	response regulator
MSIP34_RS12390	COG3850	Histidine kinase
MSIP34_RS12420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MSIP34_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS12470	COG0657	acetylesterase activity
MSIP34_RS12475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS12490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MSIP34_RS12500	COG0629	single-stranded DNA binding
MSIP34_RS12505	COG2814	Major facilitator Superfamily
MSIP34_RS12520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MSIP34_RS12525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MSIP34_RS12535	COG0174	glutamine synthetase
MSIP34_RS12545	COG3852	Histidine kinase
MSIP34_RS12570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MSIP34_RS12575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MSIP34_RS12625	COG0134	indole-3-glycerol-phosphate synthase activity
MSIP34_RS12635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MSIP34_RS12640	COG0512	Glutamine amidotransferase of anthranilate synthase
MSIP34_RS12650	COG0546	phosphoglycolate phosphatase activity
MSIP34_RS12655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MSIP34_RS12660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MSIP34_RS12665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MSIP34_RS12675	COG2890	protein-(glutamine-N5) methyltransferase activity
MSIP34_RS12685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MSIP34_RS12690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MSIP34_RS12695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MSIP34_RS12695	COG2813	Specifically methylates the guanine in position
MSIP34_RS12705	COG2814	Major facilitator Superfamily
MSIP34_RS12715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MSIP34_RS12725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSIP34_RS12730	COG0154	amidase activity
MSIP34_RS12735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MSIP34_RS12740	COG1077	Cell shape determining protein MreB Mrl
MSIP34_RS12750	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MSIP34_RS12755	COG0768	penicillin binding
MSIP34_RS12760	COG0772	Belongs to the SEDS family
MSIP34_RS12770	COG1686	Belongs to the peptidase S11 family
MSIP34_RS12780	COG2921	Belongs to the UPF0250 family
MSIP34_RS12785	COG0321	lipoyl(octanoyl) transferase activity
MSIP34_RS12790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MSIP34_RS12830	COG2890	protein-(glutamine-N5) methyltransferase activity
MSIP34_RS12855	COG2010	Cytochrome c
MSIP34_RS12915	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MSIP34_RS12960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MSIP34_RS12965	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MSIP34_RS12980	COG0606	chelatase, subunit chli
MSIP34_RS12995	COG0347	Belongs to the P(II) protein family
MSIP34_RS13000	COG0004	ammonium transporteR
MSIP34_RS13010	COG0189	ligase activity
MSIP34_RS13045	COG0019	diaminopimelate decarboxylase activity
MSIP34_RS13050	COG0788	formyltetrahydrofolate deformylase activity
MSIP34_RS13060	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MSIP34_RS13065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MSIP34_RS13095	COG0659	secondary active sulfate transmembrane transporter activity
MSIP34_RS13100	COG1194	a g-specific adenine glycosylase
MSIP34_RS13110	COG3932	Exopolysaccharide synthesis, ExoD
MSIP34_RS13115	COG1968	undecaprenyl-diphosphatase activity
MSIP34_RS13125	COG1187	pseudouridine synthase activity
MSIP34_RS13130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MSIP34_RS13140	COG0300	oxidoreductase activity
MSIP34_RS13170	COG4191	Histidine kinase
MSIP34_RS13175	COG2204	response regulator
MSIP34_RS13180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MSIP34_RS13185	COG1538	Outer membrane efflux protein
MSIP34_RS13215	COG1519	Transferase
MSIP34_RS13220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MSIP34_RS13230	COG3621	Patatin-like phospholipase
MSIP34_RS13245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MSIP34_RS13250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MSIP34_RS13255	COG1116	anion transmembrane transporter activity
MSIP34_RS13260	COG2188	Transcriptional regulator
MSIP34_RS13265	COG1917	Cupin 2, conserved barrel domain protein
MSIP34_RS13265	COG4977	sequence-specific DNA binding
MSIP34_RS13295	COG0583	DNA-binding transcription factor activity
MSIP34_RS13300	COG0596	Alpha beta hydrolase
MSIP34_RS13310	COG1278	Cold shock
MSIP34_RS13315	COG2823	Periplasmic or secreted lipoprotein
MSIP34_RS13325	COG4575	ribosome binding
MSIP34_RS13360	COG3459	Glycosyltransferase 36 associated
MSIP34_RS13370	COG2375	cellular response to nickel ion
MSIP34_RS13380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MSIP34_RS13395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MSIP34_RS13400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS13415	COG2199	diguanylate cyclase activity
MSIP34_RS13415	COG3287	FIST C domain
MSIP34_RS13415	COG2200	EAL domain
MSIP34_RS13420	COG0753	catalase activity
MSIP34_RS13435	COG0583	DNA-binding transcription factor activity
MSIP34_RS13440	COG1741	Belongs to the pirin family
MSIP34_RS13450	COG1335	isochorismatase
MSIP34_RS13455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MSIP34_RS13495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MSIP34_RS13500	COG0714	Associated with various cellular activities
MSIP34_RS13535	COG0583	DNA-binding transcription factor activity
MSIP34_RS13555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MSIP34_RS13565	COG0835	chemotaxis
MSIP34_RS13570	COG0840	transmembrane signaling receptor activity
MSIP34_RS13580	COG0840	transmembrane signaling receptor activity
MSIP34_RS13595	COG0840	transmembrane signaling receptor activity
MSIP34_RS13600	COG0643	Histidine kinase
MSIP34_RS13600	COG2198	Histidine kinase
MSIP34_RS13615	COG0840	transmembrane signaling receptor activity
MSIP34_RS13625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MSIP34_RS13630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MSIP34_RS13635	COG1309	transcriptional regulator
MSIP34_RS13670	COG3706	GGDEF domain
MSIP34_RS13670	COG2203	Gaf domain
MSIP34_RS13670	COG5001	Diguanylate cyclase
MSIP34_RS13670	COG4251	negative regulation of phosphorylation
MSIP34_RS13675	COG1451	nucleotide metabolic process
MSIP34_RS13690	COG0583	DNA-binding transcription factor activity
MSIP34_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS13715	COG0443	Heat shock 70 kDa protein
MSIP34_RS13720	COG2974	May be involved in recombination
MSIP34_RS13735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MSIP34_RS13745	COG1253	flavin adenine dinucleotide binding
MSIP34_RS13750	COG1278	Cold shock
MSIP34_RS13755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MSIP34_RS13830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MSIP34_RS13830	COG4651	solute:proton antiporter activity
MSIP34_RS13850	COG0438	transferase activity, transferring glycosyl groups
MSIP34_RS13860	COG0668	transmembrane transport
MSIP34_RS13900	COG0204	Acyl-transferase
MSIP34_RS13900	COG0318	PFAM AMP-dependent synthetase and ligase
MSIP34_RS13920	COG2259	Doxx family
MSIP34_RS13925	COG3384	dioxygenase
MSIP34_RS13930	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MSIP34_RS13935	COG2967	ApaG domain
MSIP34_RS13940	COG2022	thiamine diphosphate biosynthetic process
MSIP34_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
MSIP34_RS14030	COG1773	rubredoxin
MSIP34_RS14040	COG0352	thiamine-phosphate diphosphorylase activity
MSIP34_RS14045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MSIP34_RS14050	COG0067	glutamate synthase
MSIP34_RS14050	COG0070	glutamate synthase
MSIP34_RS14050	COG0069	glutamate synthase activity
MSIP34_RS14060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MSIP34_RS14065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MSIP34_RS14070	COG0018	arginyl-trna synthetase
MSIP34_RS14090	COG3706	GGDEF domain
MSIP34_RS14090	COG5001	Diguanylate cyclase
MSIP34_RS14090	COG4251	negative regulation of phosphorylation
MSIP34_RS14090	COG2203	Gaf domain
MSIP34_RS14095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MSIP34_RS14100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MSIP34_RS14105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MSIP34_RS14110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MSIP34_RS14115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MSIP34_RS14120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MSIP34_RS14125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MSIP34_RS14130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MSIP34_RS14140	COG0356	it plays a direct role in the translocation of protons across the membrane
MSIP34_RS14150	COG1475	DNA binding
MSIP34_RS14155	COG1192	Involved in chromosome partitioning
MSIP34_RS14160	COG0357	Ribosomal RNA small subunit methyltransferase G
MSIP34_RS14165	COG0445	tRNA wobble uridine modification
MSIP34_RS14170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MSIP34_RS14175	COG0706	membrane insertase activity
MSIP34_RS14245	COG0579	oxidoreductase
MSIP34_RS14455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MSIP34_RS14460	COG0631	protein serine/threonine phosphatase activity
MSIP34_RS14580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MSIP34_RS14680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MSIP34_RS14700	COG4974	Belongs to the 'phage' integrase family
MSIP34_RS14705	COG0366	Alpha amylase catalytic
MSIP34_RS14765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)