locus-tag	class	description
F6J84_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F6J84_RS00010	COG0592	DNA-directed DNA polymerase activity
F6J84_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F6J84_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F6J84_RS00025	COG0187	DNA topoisomerase II activity
F6J84_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F6J84_RS00070	COG0705	Rhomboid family
F6J84_RS00095	COG2815	serine threonine protein kinase
F6J84_RS00095	COG0515	serine threonine protein kinase
F6J84_RS00100	COG0515	serine threonine protein kinase
F6J84_RS00120	COG1716	ATPase activity
F6J84_RS00125	COG1716	ATPase activity
F6J84_RS00135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6J84_RS00140	COG1278	Cold shock
F6J84_RS00145	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F6J84_RS00155	COG2239	Acts as a magnesium transporter
F6J84_RS00160	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F6J84_RS00165	COG0738	Major facilitator superfamily
F6J84_RS00170	COG1609	Transcriptional regulator
F6J84_RS00175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F6J84_RS00175	COG2111	Na H antiporter
F6J84_RS00180	COG1006	Multisubunit Na H antiporter MnhC subunit
F6J84_RS00185	COG0651	ATP synthesis coupled electron transport
F6J84_RS00195	COG2212	antiporter activity
F6J84_RS00200	COG1320	monovalent cation:proton antiporter activity
F6J84_RS00215	COG1309	transcriptional regulator
F6J84_RS00220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F6J84_RS00225	COG0137	argininosuccinate synthase activity
F6J84_RS00230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F6J84_RS00240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F6J84_RS00255	COG1605	Chorismate mutase
F6J84_RS00255	COG0287	Prephenate dehydrogenase
F6J84_RS00275	COG1131	(ABC) transporter
F6J84_RS00285	COG4175	Glycine betaine
F6J84_RS00285	COG0517	IMP dehydrogenase activity
F6J84_RS00290	COG4176	ABC-type proline glycine betaine transport system permease component
F6J84_RS00295	COG2113	Glycine betaine
F6J84_RS00310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F6J84_RS00330	COG0513	Belongs to the DEAD box helicase family
F6J84_RS00335	COG0822	iron-sulfur transferase activity
F6J84_RS00345	COG0531	amino acid
F6J84_RS00365	COG0366	Alpha amylase catalytic
F6J84_RS00370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F6J84_RS00375	COG2351	hydroxyisourate hydrolase activity
F6J84_RS00385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F6J84_RS00400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F6J84_RS00410	COG0402	S-adenosylhomocysteine deaminase activity
F6J84_RS00430	COG1116	anion transmembrane transporter activity
F6J84_RS00440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS00445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6J84_RS00455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6J84_RS00480	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS00485	COG0402	S-adenosylhomocysteine deaminase activity
F6J84_RS00510	COG3608	succinylglutamate desuccinylase aspartoacylase
F6J84_RS00510	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F6J84_RS00525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F6J84_RS00530	COG0047	phosphoribosylformylglycinamidine synthase activity
F6J84_RS00540	COG2723	6-phospho-beta-galactosidase activity
F6J84_RS00545	COG1609	Transcriptional regulator
F6J84_RS00550	COG2233	PERMEase
F6J84_RS00555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F6J84_RS00570	COG0151	Belongs to the GarS family
F6J84_RS00590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6J84_RS00595	COG1120	ATPase activity
F6J84_RS00620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F6J84_RS00670	COG2733	membrane
F6J84_RS00695	COG1780	Probably involved in ribonucleotide reductase function
F6J84_RS00700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6J84_RS00705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6J84_RS00730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F6J84_RS00755	COG0402	S-adenosylhomocysteine deaminase activity
F6J84_RS00760	COG2084	Dehydrogenase
F6J84_RS00775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F6J84_RS00780	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6J84_RS00860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6J84_RS00870	COG2017	converts alpha-aldose to the beta-anomer
F6J84_RS00875	COG0513	Belongs to the DEAD box helicase family
F6J84_RS00890	COG1960	acyl-CoA dehydrogenase activity
F6J84_RS00915	COG1472	Belongs to the glycosyl hydrolase 3 family
F6J84_RS00935	COG0519	Catalyzes the synthesis of GMP from XMP
F6J84_RS00970	COG0463	Glycosyl transferase, family 2
F6J84_RS00980	COG0659	secondary active sulfate transmembrane transporter activity
F6J84_RS00985	COG2076	Multidrug Resistance protein
F6J84_RS01000	COG4249	Peptidase C14 caspase catalytic subunit p20
F6J84_RS01030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS01035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS01040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F6J84_RS01040	COG1116	anion transmembrane transporter activity
F6J84_RS01070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6J84_RS01075	COG0179	Fumarylacetoacetate (FAA) hydrolase
F6J84_RS01095	COG0531	amino acid
F6J84_RS01100	COG0076	glutamate decarboxylase activity
F6J84_RS01105	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F6J84_RS01160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F6J84_RS01165	COG0037	tRNA processing
F6J84_RS01170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F6J84_RS01175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F6J84_RS01180	COG0302	gtp cyclohydrolase
F6J84_RS01185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F6J84_RS01190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F6J84_RS01195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F6J84_RS01220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F6J84_RS01235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6J84_RS01245	COG0542	response to heat
F6J84_RS01250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F6J84_RS01260	COG0833	amino acid
F6J84_RS01270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F6J84_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS01295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F6J84_RS01305	COG1079	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS01310	COG4603	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS01315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F6J84_RS01320	COG1129	ABC transporter
F6J84_RS01335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6J84_RS01360	COG0747	negative chemotaxis
F6J84_RS01365	COG0601	transmembrane transport
F6J84_RS01370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS01385	COG0039	L-malate dehydrogenase activity
F6J84_RS01420	COG0395	ABC-type sugar transport system, permease component
F6J84_RS01445	COG2197	response regulator
F6J84_RS01450	COG4585	Histidine kinase
F6J84_RS01460	COG1131	(ABC) transporter
F6J84_RS01470	COG1301	dicarboxylic acid transport
F6J84_RS01475	COG0596	Alpha beta hydrolase
F6J84_RS01490	COG1609	Transcriptional regulator
F6J84_RS01495	COG0673	inositol 2-dehydrogenase activity
F6J84_RS01510	COG1960	acyl-CoA dehydrogenase activity
F6J84_RS01565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F6J84_RS01570	COG0076	glutamate decarboxylase activity
F6J84_RS01595	COG0025	NhaP-type Na H and K H
F6J84_RS01620	COG1024	Enoyl-CoA hydratase
F6J84_RS01625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F6J84_RS01635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6J84_RS01640	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS01690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F6J84_RS01720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F6J84_RS01740	COG0686	Belongs to the AlaDH PNT family
F6J84_RS01745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS01775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F6J84_RS01780	COG1472	Belongs to the glycosyl hydrolase 3 family
F6J84_RS01785	COG0395	ABC-type sugar transport system, permease component
F6J84_RS01790	COG1175	transmembrane transport
F6J84_RS01810	COG2115	Belongs to the xylose isomerase family
F6J84_RS01815	COG1070	Carbohydrate kinase
F6J84_RS01825	COG0475	glutathione-regulated potassium exporter activity
F6J84_RS01880	COG1201	RNA secondary structure unwinding
F6J84_RS01890	COG0488	(ABC) transporter
F6J84_RS01925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F6J84_RS01930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F6J84_RS01935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS01940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F6J84_RS01945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS01955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F6J84_RS01970	COG4585	Histidine kinase
F6J84_RS01975	COG2197	response regulator
F6J84_RS01980	COG1136	(ABC) transporter
F6J84_RS01980	COG0577	efflux transmembrane transporter activity
F6J84_RS02015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F6J84_RS02025	COG0085	RNA polymerase activity
F6J84_RS02030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F6J84_RS02060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F6J84_RS02065	COG0049	tRNA binding
F6J84_RS02070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6J84_RS02075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6J84_RS02095	COG0438	transferase activity, transferring glycosyl groups
F6J84_RS02100	COG0297	glycogen (starch) synthase activity
F6J84_RS02120	COG0463	Glycosyl transferase, family 2
F6J84_RS02125	COG0463	Glycosyl transferase, family 2
F6J84_RS02140	COG0463	Glycosyl transferase, family 2
F6J84_RS02160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6J84_RS02175	COG0051	transcription antitermination factor activity, RNA binding
F6J84_RS02180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F6J84_RS02185	COG0088	Forms part of the polypeptide exit tunnel
F6J84_RS02190	COG0089	rRNA binding
F6J84_RS02195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F6J84_RS02200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F6J84_RS02205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F6J84_RS02210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F6J84_RS02215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F6J84_RS02220	COG0255	Belongs to the universal ribosomal protein uL29 family
F6J84_RS02225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F6J84_RS02230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F6J84_RS02235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F6J84_RS02240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F6J84_RS02245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F6J84_RS02250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F6J84_RS02255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F6J84_RS02260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F6J84_RS02265	COG1841	ribosomal large subunit assembly
F6J84_RS02270	COG0200	Binds to the 23S rRNA
F6J84_RS02280	COG0563	adenylate kinase activity
F6J84_RS02285	COG0024	Methionine aminopeptidase
F6J84_RS02295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F6J84_RS02305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F6J84_RS02310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F6J84_RS02315	COG0202	RNA polymerase activity
F6J84_RS02320	COG0203	ribosomal protein L17
F6J84_RS02325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F6J84_RS02325	COG2755	lipolytic protein G-D-S-L family
F6J84_RS02330	COG0101	tRNA pseudouridine synthase activity
F6J84_RS02360	COG0745	RESPONSE REGULATOR receiver
F6J84_RS02370	COG0589	response to stress
F6J84_RS02390	COG2160	L-arabinose isomerase activity
F6J84_RS02395	COG2017	converts alpha-aldose to the beta-anomer
F6J84_RS02415	COG2188	Transcriptional regulator
F6J84_RS02425	COG0154	amidase activity
F6J84_RS02430	COG0251	oxidation-reduction process
F6J84_RS02435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS02440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS02445	COG1116	anion transmembrane transporter activity
F6J84_RS02455	COG0179	Fumarylacetoacetate (FAA) hydrolase
F6J84_RS02460	COG1760	l-serine dehydratase
F6J84_RS02520	COG2066	Belongs to the glutaminase family
F6J84_RS02525	COG3842	ATPase activity
F6J84_RS02565	COG4607	ABC-type enterochelin transport system periplasmic component
F6J84_RS02570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6J84_RS02575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6J84_RS02580	COG1120	ATPase activity
F6J84_RS02590	COG2197	response regulator
F6J84_RS02635	COG0745	RESPONSE REGULATOR receiver
F6J84_RS02665	COG0420	3'-5' exonuclease activity
F6J84_RS02670	COG0419	ATPase involved in DNA repair
F6J84_RS02695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F6J84_RS02695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6J84_RS02705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F6J84_RS02710	COG0590	tRNA wobble adenosine to inosine editing
F6J84_RS02730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F6J84_RS02735	COG0569	domain protein
F6J84_RS02740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F6J84_RS02745	COG0640	Transcriptional regulator
F6J84_RS02765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6J84_RS02780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6J84_RS02795	COG0017	Asparaginyl-tRNA synthetase
F6J84_RS02805	COG0586	Pfam SNARE associated Golgi protein
F6J84_RS02810	COG0406	alpha-ribazole phosphatase activity
F6J84_RS02820	COG0785	Cytochrome C biogenesis protein
F6J84_RS02825	COG1333	cytochrome c biogenesis protein
F6J84_RS02830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6J84_RS02845	COG2409	Drug exporters of the RND superfamily
F6J84_RS02855	COG4948	Mandelate Racemase Muconate Lactonizing
F6J84_RS02865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F6J84_RS02875	COG1575	Belongs to the MenA family. Type 1 subfamily
F6J84_RS02890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F6J84_RS02905	COG2226	methyltransferase
F6J84_RS02910	COG0142	geranyltranstransferase activity
F6J84_RS02935	COG1666	GTP binding
F6J84_RS02955	COG0121	glutamine amidotransferase
F6J84_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS03005	COG1309	transcriptional regulator
F6J84_RS03065	COG0535	radical SAM domain protein
F6J84_RS03090	COG1414	Transcriptional regulator
F6J84_RS03125	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS03170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS03175	COG0444	Belongs to the ABC transporter superfamily
F6J84_RS03180	COG4608	Belongs to the ABC transporter superfamily
F6J84_RS03195	COG2873	o-acetylhomoserine
F6J84_RS03200	COG1832	CoA-binding protein
F6J84_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS03215	COG0730	response to heat
F6J84_RS03220	COG2030	dehydratase
F6J84_RS03230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F6J84_RS03240	COG0436	Aminotransferase
F6J84_RS03245	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F6J84_RS03245	COG0778	Nitroreductase
F6J84_RS03255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F6J84_RS03265	COG1362	aminopeptidase activity
F6J84_RS03275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6J84_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS03335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F6J84_RS03340	COG0081	regulation of translation
F6J84_RS03345	COG1254	Belongs to the acylphosphatase family
F6J84_RS03365	COG0477	Major facilitator Superfamily
F6J84_RS03385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F6J84_RS03390	COG0222	ribosome binding
F6J84_RS03400	COG1609	Transcriptional regulator
F6J84_RS03405	COG1653	transport
F6J84_RS03410	COG1175	transmembrane transport
F6J84_RS03415	COG0395	ABC-type sugar transport system, permease component
F6J84_RS03420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6J84_RS03440	COG2814	Major facilitator Superfamily
F6J84_RS03455	COG0702	epimerase
F6J84_RS03460	COG0315	cyclic pyranopterin monophosphate synthase activity
F6J84_RS03460	COG0521	Mo-molybdopterin cofactor biosynthetic process
F6J84_RS03480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F6J84_RS03480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F6J84_RS03485	COG0315	cyclic pyranopterin monophosphate synthase activity
F6J84_RS03500	COG3585	molybdate ion transport
F6J84_RS03520	COG0456	acetyltransferase
F6J84_RS03525	COG4988	ABC transporter
F6J84_RS03530	COG4988	ABC transporter
F6J84_RS03535	COG1294	oxidase, subunit
F6J84_RS03540	COG1271	oxidase subunit
F6J84_RS03545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F6J84_RS03550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F6J84_RS03570	COG1278	Cold shock
F6J84_RS03600	COG2986	histidine ammonia-lyase
F6J84_RS03605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F6J84_RS03615	COG1228	amidohydrolase
F6J84_RS03620	COG1228	amidohydrolase
F6J84_RS03625	COG0477	Major facilitator Superfamily
F6J84_RS03680	COG0714	Associated with various cellular activities
F6J84_RS03695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F6J84_RS03715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F6J84_RS03735	COG0579	oxidoreductase
F6J84_RS03740	COG4941	Belongs to the sigma-70 factor family
F6J84_RS03770	COG1408	metallophosphoesterase
F6J84_RS03775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F6J84_RS03790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F6J84_RS03820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6J84_RS03820	COG1754	DNA topoisomerase type I activity
F6J84_RS03825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F6J84_RS03830	COG0470	DNA polymerase III
F6J84_RS03840	COG2011	ABC-type metal ion transport system permease component
F6J84_RS03845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F6J84_RS03865	COG2409	Drug exporters of the RND superfamily
F6J84_RS03870	COG1335	isochorismatase
F6J84_RS03910	COG2161	toxin-antitoxin pair type II binding
F6J84_RS03920	COG0310	cobalt ion transport
F6J84_RS03945	COG1595	DNA-templated transcription, initiation
F6J84_RS03965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6J84_RS03975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F6J84_RS03990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6J84_RS04000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F6J84_RS04005	COG0745	RESPONSE REGULATOR receiver
F6J84_RS04015	COG4044	May play a role in the intracellular transport of hydrophobic ligands
F6J84_RS04030	COG0588	phosphoglycerate mutase activity
F6J84_RS04040	COG5002	protein histidine kinase activity
F6J84_RS04045	COG0745	RESPONSE REGULATOR receiver
F6J84_RS04055	COG1329	Transcriptional regulator
F6J84_RS04060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F6J84_RS04060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F6J84_RS04065	COG0454	-acetyltransferase
F6J84_RS04070	COG0697	spore germination
F6J84_RS04075	COG0215	cysteine-tRNA ligase activity
F6J84_RS04080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6J84_RS04085	COG2910	NAD(P)H-binding
F6J84_RS04095	COG3842	ATPase activity
F6J84_RS04135	COG0778	Nitroreductase
F6J84_RS04140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6J84_RS04165	COG0459	protein refolding
F6J84_RS04175	COG2205	protein histidine kinase activity
F6J84_RS04180	COG0745	RESPONSE REGULATOR receiver
F6J84_RS04185	COG1061	Type III restriction enzyme res subunit
F6J84_RS04200	COG1278	Cold shock
F6J84_RS04215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F6J84_RS04235	COG1846	Transcriptional regulator
F6J84_RS04240	COG0697	spore germination
F6J84_RS04245	COG1335	isochorismatase
F6J84_RS04260	COG0587	DNA-directed DNA polymerase activity
F6J84_RS04270	COG0028	Belongs to the TPP enzyme family
F6J84_RS04275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F6J84_RS04335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F6J84_RS04380	COG2897	thiosulfate sulfurtransferase activity
F6J84_RS04400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F6J84_RS04415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F6J84_RS04435	COG1609	Transcriptional regulator
F6J84_RS04450	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS04460	COG1879	ABC-type sugar transport system periplasmic component
F6J84_RS04480	COG0702	epimerase
F6J84_RS04525	COG0598	Magnesium transport protein CorA
F6J84_RS04540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6J84_RS04545	COG0798	PFAM Bile acid sodium symporter
F6J84_RS04550	COG2217	Heavy metal translocating P-type atpase
F6J84_RS04555	COG1136	(ABC) transporter
F6J84_RS04555	COG0577	efflux transmembrane transporter activity
F6J84_RS04575	COG2197	response regulator
F6J84_RS04585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6J84_RS04605	COG1970	mechanosensitive ion channel activity
F6J84_RS04620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F6J84_RS04665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F6J84_RS04670	COG2813	Specifically methylates the guanine in position
F6J84_RS04695	COG0542	response to heat
F6J84_RS04700	COG1793	dna ligase
F6J84_RS04705	COG4214	carbohydrate transport
F6J84_RS04715	COG4213	ABC transporter substrate-binding protein
F6J84_RS04720	COG4214	carbohydrate transport
F6J84_RS04730	COG4213	ABC transporter substrate-binding protein
F6J84_RS04735	COG1940	carbohydrate kinase activity
F6J84_RS04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6J84_RS04770	COG1609	Transcriptional regulator
F6J84_RS04775	COG0235	Class ii aldolase
F6J84_RS04780	COG4213	ABC transporter substrate-binding protein
F6J84_RS04790	COG4214	carbohydrate transport
F6J84_RS04810	COG1643	Atp-dependent helicase
F6J84_RS04845	COG0714	Associated with various cellular activities
F6J84_RS04865	COG1331	Highly conserved protein containing a thioredoxin domain
F6J84_RS04870	COG1846	Transcriptional regulator
F6J84_RS04890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6J84_RS04895	COG0084	hydrolase, TatD family'
F6J84_RS04905	COG4941	Belongs to the sigma-70 factor family
F6J84_RS04930	COG0477	Major facilitator Superfamily
F6J84_RS04935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F6J84_RS04950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F6J84_RS04955	COG4552	Acetyltransferase involved in intracellular survival and related
F6J84_RS04965	COG0517	IMP dehydrogenase activity
F6J84_RS04965	COG1125	glycine betaine transport
F6J84_RS04970	COG1174	glycine betaine transport
F6J84_RS04985	COG0488	(ABC) transporter
F6J84_RS05005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F6J84_RS05010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F6J84_RS05025	COG1017	nitric oxide dioxygenase activity
F6J84_RS05025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F6J84_RS05030	COG0166	Belongs to the GPI family
F6J84_RS05035	COG2205	protein histidine kinase activity
F6J84_RS05040	COG0745	RESPONSE REGULATOR receiver
F6J84_RS05050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F6J84_RS05055	COG3265	gluconokinase activity
F6J84_RS05060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F6J84_RS05065	COG0193	aminoacyl-tRNA hydrolase activity
F6J84_RS05090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F6J84_RS05100	COG0124	histidyl-tRNA synthetase
F6J84_RS05110	COG1929	Belongs to the glycerate kinase type-1 family
F6J84_RS05115	COG4122	O-methyltransferase activity
F6J84_RS05120	COG0148	phosphopyruvate hydratase activity
F6J84_RS05135	COG1404	Belongs to the peptidase S8 family
F6J84_RS05165	COG4251	negative regulation of phosphorylation
F6J84_RS05185	COG1704	LemA family
F6J84_RS05190	COG3214	Protein conserved in bacteria
F6J84_RS05200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F6J84_RS05205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6J84_RS05225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F6J84_RS05230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F6J84_RS05240	COG5002	protein histidine kinase activity
F6J84_RS05245	COG0114	fumarate hydratase activity
F6J84_RS05260	COG1722	exodeoxyribonuclease VII activity
F6J84_RS05265	COG1570	exodeoxyribonuclease VII activity
F6J84_RS05270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F6J84_RS05285	COG0191	fructose-bisphosphate aldolase activity
F6J84_RS05300	COG1322	Protein conserved in bacteria
F6J84_RS05315	COG0012	GTP binding
F6J84_RS05325	COG0657	acetylesterase activity
F6J84_RS05355	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6J84_RS05355	COG0596	Alpha beta hydrolase
F6J84_RS05360	COG1739	Uncharacterized protein family UPF0029
F6J84_RS05400	COG0488	(ABC) transporter
F6J84_RS05415	COG1937	Protein conserved in bacteria
F6J84_RS05420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F6J84_RS05460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F6J84_RS05465	COG3546	catalase activity
F6J84_RS05470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F6J84_RS05475	COG1121	(ABC) transporter
F6J84_RS05480	COG0803	Belongs to the bacterial solute-binding protein 9 family
F6J84_RS05490	COG0693	protein deglycase activity
F6J84_RS05495	COG2814	Major facilitator Superfamily
F6J84_RS05505	COG1132	(ABC) transporter
F6J84_RS05525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F6J84_RS05530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F6J84_RS05545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6J84_RS05550	COG0509	glycine decarboxylation via glycine cleavage system
F6J84_RS05555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6J84_RS05555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6J84_RS05580	COG4166	transmembrane transport
F6J84_RS05585	COG0601	transmembrane transport
F6J84_RS05590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS05625	COG1217	gtp-binding protein TYPA
F6J84_RS05660	COG1620	l-lactate permease
F6J84_RS05665	COG2326	polyphosphate kinase activity
F6J84_RS05670	COG2171	N-acyltransferase activity
F6J84_RS05675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6J84_RS05690	COG4122	O-methyltransferase activity
F6J84_RS05695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6J84_RS05710	COG2239	Acts as a magnesium transporter
F6J84_RS05720	COG0006	proline dipeptidase activity
F6J84_RS05735	COG0513	Belongs to the DEAD box helicase family
F6J84_RS05785	COG3480	Lon protease (S16) C-terminal proteolytic domain
F6J84_RS05790	COG1615	UPF0182 protein
F6J84_RS05820	COG0142	geranyltranstransferase activity
F6J84_RS05840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6J84_RS05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6J84_RS05860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F6J84_RS05865	COG1215	transferase activity, transferring glycosyl groups
F6J84_RS05905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F6J84_RS05910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F6J84_RS05915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F6J84_RS05930	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F6J84_RS05935	COG0586	Pfam SNARE associated Golgi protein
F6J84_RS05955	COG4566	intracellular signal transduction
F6J84_RS06005	COG0277	FAD linked oxidase domain protein
F6J84_RS06015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F6J84_RS06020	COG2884	Cell division ATP-binding protein ftsE
F6J84_RS06025	COG2177	Part of the ABC transporter FtsEX involved in
F6J84_RS06030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F6J84_RS06125	COG2267	carboxylic ester hydrolase activity
F6J84_RS06175	COG0318	PFAM AMP-dependent synthetase and ligase
F6J84_RS06185	COG1063	alcohol dehydrogenase
F6J84_RS06195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6J84_RS06225	COG0483	inositol monophosphate 1-phosphatase activity
F6J84_RS06240	COG0300	oxidoreductase activity
F6J84_RS06255	COG2409	Drug exporters of the RND superfamily
F6J84_RS06270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F6J84_RS06300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F6J84_RS06305	COG0275	rRNA processing
F6J84_RS06310	COG0129	dihydroxy-acid dehydratase activity
F6J84_RS06325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F6J84_RS06350	COG0477	Major facilitator Superfamily
F6J84_RS06355	COG0473	3-isopropylmalate dehydrogenase activity
F6J84_RS06360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F6J84_RS06365	COG0179	Fumarylacetoacetate (FAA) hydrolase
F6J84_RS06370	COG2814	Major facilitator Superfamily
F6J84_RS06375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6J84_RS06405	COG1280	lysine exporter protein (LysE YggA)
F6J84_RS06445	COG2197	response regulator
F6J84_RS06455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F6J84_RS06470	COG1349	DNA-binding transcription factor activity
F6J84_RS06475	COG1105	Belongs to the carbohydrate kinase PfkB family
F6J84_RS06480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6J84_RS06480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6J84_RS06480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6J84_RS06510	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F6J84_RS06515	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F6J84_RS06520	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F6J84_RS06545	COG2066	Belongs to the glutaminase family
F6J84_RS06550	COG2267	carboxylic ester hydrolase activity
F6J84_RS06570	COG0583	DNA-binding transcription factor activity
F6J84_RS06610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F6J84_RS06640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F6J84_RS06645	COG0066	3-isopropylmalate dehydratase activity
F6J84_RS06650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F6J84_RS06660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F6J84_RS06665	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6J84_RS06675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F6J84_RS06680	COG0742	ribosomal rna small subunit methyltransferase
F6J84_RS06695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F6J84_RS06705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F6J84_RS06710	COG0571	ribonuclease III activity
F6J84_RS06715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F6J84_RS06730	COG1196	nuclear chromosome segregation
F6J84_RS06735	COG0552	protein localization to endoplasmic reticulum
F6J84_RS06750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS06755	COG0601	transmembrane transport
F6J84_RS06760	COG0747	negative chemotaxis
F6J84_RS06775	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F6J84_RS06780	COG0228	four-way junction DNA binding
F6J84_RS06785	COG1837	Belongs to the UPF0109 family
F6J84_RS06790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F6J84_RS06795	COG0336	Belongs to the RNA methyltransferase TrmD family
F6J84_RS06810	COG0335	large ribosomal subunit rRNA binding
F6J84_RS06820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F6J84_RS06835	COG0792	nuclease activity
F6J84_RS06865	COG0052	Belongs to the universal ribosomal protein uS2 family
F6J84_RS06870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F6J84_RS06875	COG0528	UMP kinase activity
F6J84_RS06880	COG0233	cytoplasmic translational termination
F6J84_RS06920	COG3118	belongs to the thioredoxin family
F6J84_RS06925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F6J84_RS06930	COG0366	Alpha amylase catalytic
F6J84_RS06945	COG0482	sulfurtransferase activity
F6J84_RS06950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F6J84_RS06955	COG0318	PFAM AMP-dependent synthetase and ligase
F6J84_RS06960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F6J84_RS06965	COG0154	amidase activity
F6J84_RS06970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F6J84_RS06975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F6J84_RS06995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F6J84_RS07010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F6J84_RS07045	COG0629	single-stranded DNA binding
F6J84_RS07065	COG1946	Acyl-CoA thioesterase
F6J84_RS07085	COG0668	transmembrane transport
F6J84_RS07095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F6J84_RS07100	COG0698	ribose 5-phosphate isomerase
F6J84_RS07120	COG0783	Belongs to the Dps family
F6J84_RS07140	COG1937	Protein conserved in bacteria
F6J84_RS07175	COG0544	peptidyl-prolyl cis-trans isomerase activity
F6J84_RS07180	COG0740	serine-type endopeptidase activity
F6J84_RS07185	COG0740	serine-type endopeptidase activity
F6J84_RS07190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F6J84_RS07205	COG0525	valine-tRNA ligase activity
F6J84_RS07215	COG0322	excinuclease ABC activity
F6J84_RS07220	COG1660	Displays ATPase and GTPase activities
F6J84_RS07225	COG1481	regulation of sporulation
F6J84_RS07230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F6J84_RS07235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F6J84_RS07240	COG0126	phosphoglycerate kinase activity
F6J84_RS07245	COG0149	triose-phosphate isomerase activity
F6J84_RS07250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F6J84_RS07260	COG0363	glucosamine-6-phosphate deaminase activity
F6J84_RS07275	COG0166	Belongs to the GPI family
F6J84_RS07280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F6J84_RS07290	COG0109	protoheme IX farnesyltransferase activity
F6J84_RS07300	COG1612	heme a metabolic process
F6J84_RS07320	COG0396	ATPase activity
F6J84_RS07325	COG2151	metal-sulfur cluster biosynthetic enzyme
F6J84_RS07330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F6J84_RS07340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6J84_RS07345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6J84_RS07350	COG1120	ATPase activity
F6J84_RS07360	COG1268	BioY protein
F6J84_RS07365	COG0488	(ABC) transporter
F6J84_RS07390	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS07410	COG0560	Phosphoserine phosphatase
F6J84_RS07415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F6J84_RS07420	COG0297	glycogen (starch) synthase activity
F6J84_RS07425	COG1119	ATPase activity
F6J84_RS07430	COG0254	rRNA binding
F6J84_RS07465	COG0022	dehydrogenase e1 component
F6J84_RS07470	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6J84_RS07480	COG1960	acyl-CoA dehydrogenase activity
F6J84_RS07530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6J84_RS07535	COG1968	undecaprenyl-diphosphatase activity
F6J84_RS07545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F6J84_RS07570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6J84_RS07575	COG0805	protein transport
F6J84_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS07610	COG0783	Belongs to the Dps family
F6J84_RS07615	COG3387	PFAM Glycoside hydrolase 15-related
F6J84_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS07630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F6J84_RS07635	COG0492	ferredoxin-NADP+ reductase activity
F6J84_RS07640	COG0640	Transcriptional regulator
F6J84_RS07645	COG0456	acetyltransferase
F6J84_RS07650	COG2501	S4 domain
F6J84_RS07665	COG2267	carboxylic ester hydrolase activity
F6J84_RS07680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS07740	COG0469	pyruvate kinase activity
F6J84_RS07750	COG0067	glutamate synthase
F6J84_RS07750	COG0069	glutamate synthase activity
F6J84_RS07750	COG0070	glutamate synthase
F6J84_RS07755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F6J84_RS07760	COG0159	tryptophan synthase activity
F6J84_RS07765	COG0133	tryptophan synthase activity
F6J84_RS07770	COG0134	indole-3-glycerol-phosphate synthase activity
F6J84_RS07785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F6J84_RS07790	COG0107	imidazoleglycerol-phosphate synthase activity
F6J84_RS07795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F6J84_RS07800	COG0140	phosphoribosyl-ATP diphosphatase activity
F6J84_RS07805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F6J84_RS07815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F6J84_RS07820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F6J84_RS07825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F6J84_RS07830	COG1758	RNA polymerase activity
F6J84_RS07835	COG0194	GDP metabolic process
F6J84_RS07840	COG0284	orotidine-5'-phosphate decarboxylase activity
F6J84_RS07845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F6J84_RS07850	COG0505	Belongs to the CarA family
F6J84_RS07860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F6J84_RS07865	COG0540	Belongs to the ATCase OTCase family
F6J84_RS07870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F6J84_RS07875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F6J84_RS07875	COG2146	nitrite reductase [NAD(P)H] activity
F6J84_RS07880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F6J84_RS07885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6J84_RS07890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F6J84_RS07895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F6J84_RS07900	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F6J84_RS07900	COG1082	Xylose isomerase domain protein TIM barrel
F6J84_RS07905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F6J84_RS07910	COG0477	Major facilitator Superfamily
F6J84_RS07915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F6J84_RS07920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F6J84_RS07925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F6J84_RS07935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F6J84_RS07940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F6J84_RS07945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F6J84_RS07955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F6J84_RS07970	COG1196	nuclear chromosome segregation
F6J84_RS07980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6J84_RS07985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6J84_RS07990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6J84_RS08000	COG2255	four-way junction helicase activity
F6J84_RS08005	COG0632	four-way junction helicase activity
F6J84_RS08010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F6J84_RS08015	COG0217	transcriptional regulatory protein
F6J84_RS08025	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F6J84_RS08030	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F6J84_RS08040	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F6J84_RS08050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F6J84_RS08130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F6J84_RS08150	COG3281	Trehalose synthase
F6J84_RS08170	COG0183	Belongs to the thiolase family
F6J84_RS08175	COG1250	3-hydroxyacyl-CoA dehydrogenase
F6J84_RS08175	COG1024	Enoyl-CoA hydratase
F6J84_RS08180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F6J84_RS08185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F6J84_RS08200	COG0756	dUTP diphosphatase activity
F6J84_RS08225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F6J84_RS08230	COG0187	DNA topoisomerase II activity
F6J84_RS08240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6J84_RS08245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6J84_RS08260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6J84_RS08270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F6J84_RS08275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6J84_RS08280	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6J84_RS08300	COG0174	glutamine synthetase
F6J84_RS08330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F6J84_RS08335	COG0174	glutamine synthetase
F6J84_RS08365	COG1116	anion transmembrane transporter activity
F6J84_RS08375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS08380	COG2133	pyrroloquinoline quinone binding
F6J84_RS08435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6J84_RS08470	COG2268	Band 7 protein
F6J84_RS08475	COG3896	Chloramphenicol phosphotransferase-like protein
F6J84_RS08485	COG4608	Belongs to the ABC transporter superfamily
F6J84_RS08490	COG0358	DNA primase activity
F6J84_RS08505	COG0386	Belongs to the glutathione peroxidase family
F6J84_RS08520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F6J84_RS08525	COG1381	Involved in DNA repair and RecF pathway recombination
F6J84_RS08530	COG2860	membrane
F6J84_RS08535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6J84_RS08540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F6J84_RS08550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F6J84_RS08560	COG0537	adenosine 5'-monophosphoramidase activity
F6J84_RS08570	COG0484	heat shock protein binding
F6J84_RS08575	COG1420	regulation of RNA biosynthetic process
F6J84_RS08590	COG0481	GTPase activity
F6J84_RS08595	COG2267	carboxylic ester hydrolase activity
F6J84_RS08600	COG0268	Binds directly to 16S ribosomal RNA
F6J84_RS08605	COG3527	Alpha-acetolactate decarboxylase
F6J84_RS08620	COG1596	polysaccharide export
F6J84_RS08620	COG1555	photosystem II stabilization
F6J84_RS08625	COG0495	leucyl-tRNA aminoacylation
F6J84_RS08630	COG0512	Glutamine amidotransferase of anthranilate synthase
F6J84_RS08630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F6J84_RS08645	COG2135	peptidase activity
F6J84_RS08680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F6J84_RS08690	COG2197	response regulator
F6J84_RS08695	COG4585	Histidine kinase
F6J84_RS08705	COG1131	(ABC) transporter
F6J84_RS08715	COG0546	phosphoglycolate phosphatase activity
F6J84_RS08730	COG0640	Transcriptional regulator
F6J84_RS08740	COG3268	Saccharopine dehydrogenase
F6J84_RS08800	COG0799	negative regulation of ribosome biogenesis
F6J84_RS08810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F6J84_RS08820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F6J84_RS08825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F6J84_RS08830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F6J84_RS08835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F6J84_RS08840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F6J84_RS08850	COG1530	ribonuclease E activity
F6J84_RS08885	COG0105	UTP biosynthetic process
F6J84_RS08900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F6J84_RS08905	COG1846	Transcriptional regulator
F6J84_RS08920	COG0556	nucleotide-excision repair
F6J84_RS08925	COG0237	dephospho-CoA kinase activity
F6J84_RS08935	COG5002	protein histidine kinase activity
F6J84_RS08945	COG5002	protein histidine kinase activity
F6J84_RS08955	COG0539	negative regulation of cytoplasmic translation
F6J84_RS08965	COG0745	RESPONSE REGULATOR receiver
F6J84_RS08970	COG2205	protein histidine kinase activity
F6J84_RS08980	COG3655	Transcriptional regulator
F6J84_RS08990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS09010	COG0596	Alpha beta hydrolase
F6J84_RS09030	COG2124	cytochrome p450
F6J84_RS09035	COG3639	organic phosphonate transmembrane transporter activity
F6J84_RS09040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F6J84_RS09085	COG0494	nUDIX hydrolase
F6J84_RS09105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6J84_RS09110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6J84_RS09130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F6J84_RS09135	COG1695	Transcriptional regulator
F6J84_RS09140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F6J84_RS09165	COG0733	neurotransmitter:sodium symporter activity
F6J84_RS09195	COG0328	RNA-DNA hybrid ribonuclease activity
F6J84_RS09200	COG1054	Belongs to the UPF0176 family
F6J84_RS09220	COG2072	flavoprotein involved in K transport
F6J84_RS09230	COG3012	SEC-C Motif Domain Protein
F6J84_RS09250	COG4129	membrane
F6J84_RS09255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F6J84_RS09280	COG1796	DNA polymerase
F6J84_RS09280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F6J84_RS09285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F6J84_RS09290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F6J84_RS09295	COG1845	cytochrome c oxidase, subunit III
F6J84_RS09300	COG2010	Cytochrome c
F6J84_RS09305	COG0723	plastoquinol--plastocyanin reductase activity
F6J84_RS09310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F6J84_RS09315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6J84_RS09335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F6J84_RS09340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F6J84_RS09360	COG0167	dihydroorotate dehydrogenase activity
F6J84_RS09365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F6J84_RS09370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F6J84_RS09380	COG0587	DNA-directed DNA polymerase activity
F6J84_RS09400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F6J84_RS09415	COG1799	cell septum assembly
F6J84_RS09420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F6J84_RS09435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6J84_RS09440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F6J84_RS09450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F6J84_RS09455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F6J84_RS09465	COG0768	penicillin binding
F6J84_RS09475	COG0275	rRNA processing
F6J84_RS09480	COG2001	Belongs to the MraZ family
F6J84_RS09490	COG0142	geranyltranstransferase activity
F6J84_RS09500	COG3942	CHAP domain
F6J84_RS09500	COG1388	LysM domain
F6J84_RS09505	COG0515	serine threonine protein kinase
F6J84_RS09505	COG2815	serine threonine protein kinase
F6J84_RS09510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F6J84_RS09515	COG0204	Acyl-transferase
F6J84_RS09520	COG1940	carbohydrate kinase activity
F6J84_RS09525	COG1022	Amp-dependent synthetase and ligase
F6J84_RS09545	COG1192	Involved in chromosome partitioning
F6J84_RS09560	COG1716	ATPase activity
F6J84_RS09565	COG2372	response to copper ion
F6J84_RS09610	COG0667	Aldo Keto reductase
F6J84_RS09645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6J84_RS09670	COG2146	nitrite reductase [NAD(P)H] activity
F6J84_RS09680	COG1309	transcriptional regulator
F6J84_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS09730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F6J84_RS09735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6J84_RS09780	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
F6J84_RS09845	COG1160	GTP binding
F6J84_RS09850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F6J84_RS09865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F6J84_RS09870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F6J84_RS09885	COG0494	nUDIX hydrolase
F6J84_RS09890	COG0504	CTP synthase activity
F6J84_RS09895	COG0497	DNA recombination
F6J84_RS09900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F6J84_RS09910	COG0647	UMP catabolic process
F6J84_RS09945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F6J84_RS09960	COG0165	Argininosuccinate lyase
F6J84_RS09970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F6J84_RS09975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F6J84_RS09980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F6J84_RS09985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F6J84_RS09990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F6J84_RS09995	COG0072	phenylalanine-tRNA ligase activity
F6J84_RS09995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6J84_RS10000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F6J84_RS10005	COG0765	amino acid transport
F6J84_RS10010	COG0765	amino acid transport
F6J84_RS10020	COG1126	abc transporter atp-binding protein
F6J84_RS10025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6J84_RS10030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F6J84_RS10035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F6J84_RS10040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F6J84_RS10055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F6J84_RS10060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F6J84_RS10065	COG0131	Imidazoleglycerol-phosphate dehydratase
F6J84_RS10070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6J84_RS10080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F6J84_RS10095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F6J84_RS10100	COG2813	Specifically methylates the guanine in position
F6J84_RS10110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F6J84_RS10115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F6J84_RS10120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6J84_RS10140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F6J84_RS10150	COG1396	sequence-specific DNA binding
F6J84_RS10155	COG1058	Belongs to the CinA family
F6J84_RS10155	COG1546	Belongs to the CinA family
F6J84_RS10165	COG1674	ftsk spoiiie
F6J84_RS10175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F6J84_RS10180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6J84_RS10195	COG0300	oxidoreductase activity
F6J84_RS10200	COG1122	ATPase activity
F6J84_RS10215	COG0310	cobalt ion transport
F6J84_RS10230	COG4413	Urea transporter
F6J84_RS10235	COG0829	nickel cation binding
F6J84_RS10240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F6J84_RS10245	COG0830	nickel cation binding
F6J84_RS10250	COG0804	urea catabolic process
F6J84_RS10255	COG0832	Belongs to the urease beta subunit family
F6J84_RS10265	COG0831	urea catabolic process
F6J84_RS10280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F6J84_RS10285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F6J84_RS10305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F6J84_RS10350	COG0667	Aldo Keto reductase
F6J84_RS10355	COG1185	polyribonucleotide nucleotidyltransferase activity
F6J84_RS10375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS10380	COG3594	Acyltransferase
F6J84_RS10390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F6J84_RS10415	COG0545	Peptidyl-prolyl cis-trans isomerase
F6J84_RS10475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F6J84_RS10490	COG0584	glycerophosphoryl diester phosphodiesterase
F6J84_RS10495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F6J84_RS10500	COG0196	riboflavin kinase activity
F6J84_RS10515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F6J84_RS10520	COG1194	a g-specific adenine glycosylase
F6J84_RS10525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F6J84_RS10530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F6J84_RS10540	COG0195	Participates in both transcription termination and antitermination
F6J84_RS10555	COG1611	Belongs to the LOG family
F6J84_RS10560	COG0442	prolyl-tRNA aminoacylation
F6J84_RS10565	COG3135	benzoate transporter
F6J84_RS10570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F6J84_RS10580	COG0750	zinc metalloprotease
F6J84_RS10585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F6J84_RS10590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F6J84_RS10615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F6J84_RS10625	COG0631	protein serine/threonine phosphatase activity
F6J84_RS10635	COG3022	response to hydroperoxide
F6J84_RS10640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F6J84_RS10645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F6J84_RS10650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F6J84_RS10655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F6J84_RS10660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6J84_RS10665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F6J84_RS10670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6J84_RS10675	COG0356	it plays a direct role in the translocation of protons across the membrane
F6J84_RS10685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F6J84_RS10695	COG2890	protein-(glutamine-N5) methyltransferase activity
F6J84_RS10705	COG1045	serine acetyltransferase
F6J84_RS10710	COG0154	amidase activity
F6J84_RS10715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F6J84_RS10725	COG0083	homoserine kinase activity
F6J84_RS10730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F6J84_RS10735	COG0460	homoserine dehydrogenase
F6J84_RS10750	COG0018	arginyl-trna synthetase
F6J84_RS10755	COG1305	Transglutaminase-like
F6J84_RS10765	COG1971	Probably functions as a manganese efflux pump
F6J84_RS10790	COG1215	transferase activity, transferring glycosyl groups
F6J84_RS10810	COG0589	response to stress
F6J84_RS10825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F6J84_RS10840	COG1842	Phage shock protein A
F6J84_RS10845	COG0010	Belongs to the arginase family
F6J84_RS10860	COG2365	Tyrosine phosphatase family
F6J84_RS10870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F6J84_RS10870	COG0596	Alpha beta hydrolase
F6J84_RS10880	COG0601	transmembrane transport
F6J84_RS10885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS10890	COG0444	Belongs to the ABC transporter superfamily
F6J84_RS10905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F6J84_RS10910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F6J84_RS10915	COG2814	Major facilitator Superfamily
F6J84_RS10935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F6J84_RS10940	COG2814	Major facilitator Superfamily
F6J84_RS10945	COG0011	TIGRFAM Protein of
F6J84_RS10970	COG1253	flavin adenine dinucleotide binding
F6J84_RS10980	COG0567	Dehydrogenase, E1 component
F6J84_RS10980	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6J84_RS10990	COG1595	DNA-templated transcription, initiation
F6J84_RS11055	COG1177	transmembrane transport
F6J84_RS11060	COG1176	ABC-type spermidine putrescine transport system, permease component I
F6J84_RS11065	COG3842	ATPase activity
F6J84_RS11075	COG1522	sequence-specific DNA binding
F6J84_RS11080	COG0653	protein targeting
F6J84_RS11105	COG5401	PFAM Sporulation and spore germination
F6J84_RS11110	COG5002	protein histidine kinase activity
F6J84_RS11115	COG0745	RESPONSE REGULATOR receiver
F6J84_RS11135	COG0714	Associated with various cellular activities
F6J84_RS11145	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F6J84_RS11165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F6J84_RS11195	COG1482	cell wall glycoprotein biosynthetic process
F6J84_RS11235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F6J84_RS11265	COG3177	Filamentation induced by cAMP protein fic
F6J84_RS11320	COG2755	lipolytic protein G-D-S-L family
F6J84_RS11320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F6J84_RS11335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F6J84_RS11390	COG1216	Glycosyl transferase, family 2
F6J84_RS11395	COG1215	transferase activity, transferring glycosyl groups
F6J84_RS11450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F6J84_RS11475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6J84_RS11480	COG0424	maF-like protein
F6J84_RS11485	COG4770	biotin carboxylase activity
F6J84_RS11500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6J84_RS11525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F6J84_RS11530	COG2213	PTS system mannitol-specific
F6J84_RS11535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6J84_RS11540	COG0246	Mannitol dehydrogenase
F6J84_RS11545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6J84_RS11560	COG1079	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS11565	COG4603	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS11570	COG3845	ABC transporter
F6J84_RS11575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6J84_RS11580	COG1397	ADP-ribosylglycohydrolase
F6J84_RS11590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6J84_RS11610	COG2009	succinate dehydrogenase
F6J84_RS11625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F6J84_RS11640	COG0180	Tryptophanyl-tRNA synthetase
F6J84_RS11650	COG2186	Transcriptional regulator
F6J84_RS11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6J84_RS11665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F6J84_RS11670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F6J84_RS11675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F6J84_RS11695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6J84_RS11695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6J84_RS11700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F6J84_RS11710	COG0477	Major facilitator Superfamily
F6J84_RS11715	COG1132	(ABC) transporter
F6J84_RS11720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F6J84_RS11745	COG1175	transmembrane transport
F6J84_RS11780	COG1802	Transcriptional regulator
F6J84_RS11795	COG3971	2-oxopent-4-enoate hydratase activity
F6J84_RS11805	COG1305	Transglutaminase-like
F6J84_RS11815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F6J84_RS11820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F6J84_RS11835	COG0277	FAD linked oxidase domain protein
F6J84_RS11845	COG2838	Isocitrate dehydrogenase
F6J84_RS11875	COG1132	(ABC) transporter
F6J84_RS11880	COG1132	(ABC) transporter
F6J84_RS11900	COG0138	bifunctional purine biosynthesis protein purh
F6J84_RS11915	COG2252	PERMEase
F6J84_RS11930	COG0045	succinate-CoA ligase (ADP-forming) activity
F6J84_RS11940	COG1309	transcriptional regulator
F6J84_RS11945	COG1960	acyl-CoA dehydrogenase activity
F6J84_RS11950	COG0628	permease
F6J84_RS11955	COG1793	dna ligase
F6J84_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS12040	COG1063	alcohol dehydrogenase
F6J84_RS12045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6J84_RS12060	COG0584	glycerophosphoryl diester phosphodiesterase
F6J84_RS12070	COG3285	dna ligase
F6J84_RS12070	COG1793	dna ligase
F6J84_RS12090	COG2885	chlorophyll binding
F6J84_RS12095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F6J84_RS12095	COG0519	Catalyzes the synthesis of GMP from XMP
F6J84_RS12110	COG0516	GMP reductase activity
F6J84_RS12120	COG3548	integral membrane protein
F6J84_RS12165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F6J84_RS12170	COG0443	Heat shock 70 kDa protein
F6J84_RS12245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F6J84_RS12260	COG0802	atpase or kinase
F6J84_RS12265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6J84_RS12270	COG0736	holo-[acyl-carrier-protein] synthase activity
F6J84_RS12275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F6J84_RS12285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6J84_RS12330	COG2244	polysaccharide biosynthetic process
F6J84_RS12340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F6J84_RS12350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F6J84_RS12360	COG0673	inositol 2-dehydrogenase activity
F6J84_RS12375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F6J84_RS12385	COG1072	(Pantothenic acid kinase))
F6J84_RS12390	COG0248	Ppx GppA phosphatase
F6J84_RS12400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6J84_RS12405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F6J84_RS12410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F6J84_RS12420	COG1216	Glycosyl transferase, family 2
F6J84_RS12450	COG2267	carboxylic ester hydrolase activity
F6J84_RS12470	COG3237	CsbD-like
F6J84_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS12490	COG1070	Carbohydrate kinase
F6J84_RS12495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F6J84_RS12500	COG1830	Aldolase
F6J84_RS12505	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS12515	COG1129	ABC transporter
F6J84_RS12525	COG2188	Transcriptional regulator
F6J84_RS12530	COG0489	protein tyrosine kinase activity
F6J84_RS12540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6J84_RS12565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F6J84_RS12580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F6J84_RS12625	COG3833	ABC-type maltose transport systems, permease component
F6J84_RS12630	COG3842	ATPase activity
F6J84_RS12640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F6J84_RS12670	COG1090	epimerase
F6J84_RS12675	COG0596	Alpha beta hydrolase
F6J84_RS12705	COG0363	glucosamine-6-phosphate deaminase activity
F6J84_RS12715	COG1175	transmembrane transport
F6J84_RS12725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F6J84_RS12730	COG0456	acetyltransferase
F6J84_RS12735	COG1737	Transcriptional regulator
F6J84_RS12745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F6J84_RS12750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F6J84_RS12755	COG1607	acyl-coa hydrolase
F6J84_RS12770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F6J84_RS12775	COG0363	glucosamine-6-phosphate deaminase activity
F6J84_RS12805	COG5002	protein histidine kinase activity
F6J84_RS12830	COG1846	Transcriptional regulator
F6J84_RS12835	COG1764	response to oxidative stress
F6J84_RS12865	COG3507	Belongs to the glycosyl hydrolase 43 family
F6J84_RS12870	COG1024	Enoyl-CoA hydratase
F6J84_RS12875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F6J84_RS12880	COG2151	metal-sulfur cluster biosynthetic enzyme
F6J84_RS12885	COG3396	Phenylacetate-CoA oxygenase
F6J84_RS12890	COG3460	Phenylacetate-CoA oxygenase
F6J84_RS12895	COG3396	Phenylacetate-CoA oxygenase
F6J84_RS12905	COG2050	protein possibly involved in aromatic compounds catabolism
F6J84_RS12910	COG2030	dehydratase
F6J84_RS12910	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS12920	COG1024	Enoyl-CoA hydratase
F6J84_RS12925	COG2050	protein possibly involved in aromatic compounds catabolism
F6J84_RS12930	COG0477	Major facilitator Superfamily
F6J84_RS12940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F6J84_RS12945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F6J84_RS12950	COG0477	Major facilitator Superfamily
F6J84_RS12960	COG1295	ribonuclease BN
F6J84_RS12970	COG1136	(ABC) transporter
F6J84_RS12985	COG1253	flavin adenine dinucleotide binding
F6J84_RS12995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS13015	COG0583	DNA-binding transcription factor activity
F6J84_RS13030	COG1316	TRANSCRIPTIONal
F6J84_RS13040	COG0561	phosphatase activity
F6J84_RS13045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F6J84_RS13050	COG1597	lipid kinase activity
F6J84_RS13055	COG0415	Belongs to the DNA photolyase family
F6J84_RS13060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS13065	COG0077	Prephenate dehydratase
F6J84_RS13095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F6J84_RS13105	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F6J84_RS13110	COG0095	Lipoate-protein ligase
F6J84_RS13115	COG2267	carboxylic ester hydrolase activity
F6J84_RS13120	COG0477	Major facilitator Superfamily
F6J84_RS13135	COG1349	DNA-binding transcription factor activity
F6J84_RS13140	COG0149	triose-phosphate isomerase activity
F6J84_RS13145	COG0698	ribose 5-phosphate isomerase
F6J84_RS13150	COG2376	Dihydroxyacetone kinase
F6J84_RS13160	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS13165	COG1129	ABC transporter
F6J84_RS13175	COG1063	alcohol dehydrogenase
F6J84_RS13180	COG1063	alcohol dehydrogenase
F6J84_RS13185	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS13190	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS13195	COG1129	ABC transporter
F6J84_RS13200	COG1879	ABC-type sugar transport system periplasmic component
F6J84_RS13205	COG1349	DNA-binding transcription factor activity
F6J84_RS13215	COG1609	Transcriptional regulator
F6J84_RS13230	COG2814	Major facilitator Superfamily
F6J84_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS13235	COG3347	Dehydrogenase
F6J84_RS13240	COG1070	Carbohydrate kinase
F6J84_RS13255	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS13270	COG4166	transmembrane transport
F6J84_RS13285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS13290	COG0601	transmembrane transport
F6J84_RS13300	COG0129	dihydroxy-acid dehydratase activity
F6J84_RS13305	COG0492	ferredoxin-NADP+ reductase activity
F6J84_RS13310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS13340	COG0318	PFAM AMP-dependent synthetase and ligase
F6J84_RS13345	COG1960	acyl-CoA dehydrogenase activity
F6J84_RS13350	COG1414	Transcriptional regulator
F6J84_RS13365	COG2205	protein histidine kinase activity
F6J84_RS13370	COG0745	RESPONSE REGULATOR receiver
F6J84_RS13375	COG1305	Transglutaminase-like
F6J84_RS13405	COG2814	Major facilitator Superfamily
F6J84_RS13410	COG1414	Transcriptional regulator
F6J84_RS13415	COG1116	anion transmembrane transporter activity
F6J84_RS13420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS13425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS13445	COG0667	Aldo Keto reductase
F6J84_RS13460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F6J84_RS13465	COG1834	amidinotransferase
F6J84_RS13470	COG0667	Aldo Keto reductase
F6J84_RS13485	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS13500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F6J84_RS13505	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS13510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F6J84_RS13520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F6J84_RS13530	COG1024	Enoyl-CoA hydratase
F6J84_RS13535	COG0183	Belongs to the thiolase family
F6J84_RS13545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F6J84_RS13550	COG2079	MmgE PrpD family protein
F6J84_RS13565	COG0667	Aldo Keto reductase
F6J84_RS13585	COG1131	(ABC) transporter
F6J84_RS13590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F6J84_RS13595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F6J84_RS13615	COG1280	lysine exporter protein (LysE YggA)
F6J84_RS13650	COG1122	ATPase activity
F6J84_RS13655	COG4721	ABC-type cobalt transport system, permease component
F6J84_RS13670	COG0471	metal ion transport
F6J84_RS13670	COG3273	potassium ion transport
F6J84_RS13675	COG0484	heat shock protein binding
F6J84_RS13690	COG1250	3-hydroxyacyl-CoA dehydrogenase
F6J84_RS13690	COG1024	Enoyl-CoA hydratase
F6J84_RS13710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F6J84_RS13715	COG2072	flavoprotein involved in K transport
F6J84_RS13720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS13725	COG1920	GTP binding
F6J84_RS13735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F6J84_RS13750	COG0181	hydroxymethylbilane synthase activity
F6J84_RS13755	COG3253	May function as heme-dependent peroxidase
F6J84_RS13780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F6J84_RS13785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F6J84_RS13795	COG4948	Mandelate Racemase Muconate Lactonizing
F6J84_RS13800	COG0423	glycine-tRNA ligase activity
F6J84_RS13870	COG1674	ftsk spoiiie
F6J84_RS13890	COG3104	oligopeptide transport
F6J84_RS13895	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS13900	COG1129	ABC transporter
F6J84_RS13930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F6J84_RS13955	COG2814	Major facilitator Superfamily
F6J84_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS13985	COG0346	lactoylglutathione lyase activity
F6J84_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS14000	COG0179	Fumarylacetoacetate (FAA) hydrolase
F6J84_RS14010	COG1414	Transcriptional regulator
F6J84_RS14015	COG0183	Belongs to the thiolase family
F6J84_RS14020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F6J84_RS14030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F6J84_RS14035	COG2267	carboxylic ester hydrolase activity
F6J84_RS14040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F6J84_RS14050	COG3485	protocatechuate 3,4-dioxygenase
F6J84_RS14070	COG2807	transmembrane transport
F6J84_RS14075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS14090	COG4608	Belongs to the ABC transporter superfamily
F6J84_RS14095	COG0444	Belongs to the ABC transporter superfamily
F6J84_RS14100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6J84_RS14105	COG0601	transmembrane transport
F6J84_RS14120	COG2807	transmembrane transport
F6J84_RS14140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS14145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6J84_RS14150	COG1116	anion transmembrane transporter activity
F6J84_RS14155	COG2814	Major facilitator Superfamily
F6J84_RS14160	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS14165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6J84_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS14195	COG1172	Belongs to the binding-protein-dependent transport system permease family
F6J84_RS14200	COG1129	ABC transporter
F6J84_RS14205	COG1063	alcohol dehydrogenase
F6J84_RS14210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F6J84_RS14215	COG3959	Transketolase, thiamine diphosphate binding domain
F6J84_RS14220	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS14230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F6J84_RS14240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6J84_RS14250	COG0302	gtp cyclohydrolase
F6J84_RS14255	COG2186	Transcriptional regulator
F6J84_RS14280	COG0411	ABC transporter
F6J84_RS14285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6J84_RS14290	COG1414	Transcriptional regulator
F6J84_RS14295	COG0318	PFAM AMP-dependent synthetase and ligase
F6J84_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS14305	COG1846	Transcriptional regulator
F6J84_RS14310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6J84_RS14320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6J84_RS14325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F6J84_RS14330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F6J84_RS14355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F6J84_RS14395	COG2843	Capsule synthesis protein
F6J84_RS14405	COG0765	amino acid transport
F6J84_RS14420	COG3590	peptidase
F6J84_RS14425	COG0534	Mate efflux family protein
F6J84_RS14465	COG4585	Histidine kinase
F6J84_RS14470	COG2197	response regulator
F6J84_RS14475	COG4152	abc transporter atp-binding protein
F6J84_RS14490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F6J84_RS14500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F6J84_RS14530	COG0542	response to heat
F6J84_RS14535	COG4977	sequence-specific DNA binding
F6J84_RS14560	COG0438	transferase activity, transferring glycosyl groups
F6J84_RS14570	COG1028	Short-chain dehydrogenase reductase Sdr
F6J84_RS14605	COG4177	L-phenylalanine transmembrane transporter activity
F6J84_RS14615	COG0318	PFAM AMP-dependent synthetase and ligase
F6J84_RS14640	COG1960	acyl-CoA dehydrogenase activity
F6J84_RS14645	COG0183	Belongs to the thiolase family
F6J84_RS14665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F6J84_RS14680	COG0789	Transcriptional regulator
F6J84_RS14685	COG0484	heat shock protein binding
F6J84_RS14690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F6J84_RS14695	COG0443	Heat shock 70 kDa protein
F6J84_RS14725	COG0318	PFAM AMP-dependent synthetase and ligase
F6J84_RS14730	COG0717	Belongs to the dCTP deaminase family
F6J84_RS14760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F6J84_RS14765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F6J84_RS14780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F6J84_RS14825	COG3483	tryptophan 2,3-dioxygenase activity
F6J84_RS14855	COG1802	Transcriptional regulator
F6J84_RS14870	COG0444	Belongs to the ABC transporter superfamily
F6J84_RS14875	COG4608	Belongs to the ABC transporter superfamily
F6J84_RS14880	COG2267	carboxylic ester hydrolase activity
F6J84_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
F6J84_RS14890	COG1053	succinate dehydrogenase
F6J84_RS14890	COG3976	FMN-binding domain protein
F6J84_RS14890	COG0431	NADPH-dependent FMN reductase
F6J84_RS14900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6J84_RS14910	COG0596	Alpha beta hydrolase
F6J84_RS14915	COG3971	2-oxopent-4-enoate hydratase activity
F6J84_RS14930	COG2079	MmgE PrpD family protein
F6J84_RS14935	COG4166	transmembrane transport
F6J84_RS14950	COG2267	carboxylic ester hydrolase activity
F6J84_RS14955	COG3971	2-oxopent-4-enoate hydratase activity
F6J84_RS14970	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F6J84_RS14975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6J84_RS14980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6J84_RS14990	COG5006	permease, DMT superfamily
F6J84_RS15005	COG5398	heme oxygenase
F6J84_RS15010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6J84_RS15025	COG0776	regulation of translation
F6J84_RS15030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F6J84_RS15035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F6J84_RS15040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F6J84_RS15050	COG2094	Belongs to the DNA glycosylase MPG family
F6J84_RS15065	COG0701	Predicted permease
F6J84_RS15075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F6J84_RS15080	COG1121	(ABC) transporter
F6J84_RS15090	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6J84_RS15095	COG0022	dehydrogenase e1 component
F6J84_RS15105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6J84_RS15110	COG1950	PFAM Membrane protein of
F6J84_RS15125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6J84_RS15145	COG1309	transcriptional regulator
F6J84_RS15150	COG1051	belongs to the nudix hydrolase family
F6J84_RS15170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6J84_RS15205	COG0305	Participates in initiation and elongation during chromosome replication
F6J84_RS15210	COG0359	binds to the 23S rRNA
F6J84_RS15215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F6J84_RS15225	COG0360	Binds together with S18 to 16S ribosomal RNA
F6J84_RS15250	COG0601	transmembrane transport
F6J84_RS15280	COG1733	regulation of RNA biosynthetic process
F6J84_RS15285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F6J84_RS15290	COG0617	tRNA 3'-terminal CCA addition
F6J84_RS15295	COG2890	protein-(glutamine-N5) methyltransferase activity
F6J84_RS15310	COG0492	ferredoxin-NADP+ reductase activity
F6J84_RS15315	COG3118	belongs to the thioredoxin family
F6J84_RS15330	COG1192	Involved in chromosome partitioning
F6J84_RS15335	COG0357	Ribosomal RNA small subunit methyltransferase G
F6J84_RS15345	COG0706	membrane insertase activity
F6J84_RS15350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F6J84_RS15355	COG0594	ribonuclease P activity
F6J84_RS15360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F6J84_RS15555	COG0438	transferase activity, transferring glycosyl groups