locus-tag	class	description
E3O41_RS00010	COG0592	DNA-directed DNA polymerase activity
E3O41_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3O41_RS00025	COG0187	DNA topoisomerase II activity
E3O41_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3O41_RS00060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3O41_RS00070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3O41_RS00075	COG0442	prolyl-tRNA aminoacylation
E3O41_RS00090	COG0705	Rhomboid family
E3O41_RS00095	COG3415	Transposase
E3O41_RS00095	COG2801	Transposase and inactivated derivatives
E3O41_RS00115	COG2815	serine threonine protein kinase
E3O41_RS00115	COG0515	serine threonine protein kinase
E3O41_RS00120	COG0515	serine threonine protein kinase
E3O41_RS00125	COG0768	penicillin binding
E3O41_RS00140	COG1716	ATPase activity
E3O41_RS00145	COG1716	ATPase activity
E3O41_RS00155	COG1278	Cold shock
E3O41_RS00165	COG2964	Protein conserved in bacteria
E3O41_RS00170	COG0747	negative chemotaxis
E3O41_RS00180	COG1228	amidohydrolase
E3O41_RS00190	COG0444	Belongs to the ABC transporter superfamily
E3O41_RS00195	COG4608	Belongs to the ABC transporter superfamily
E3O41_RS00205	COG0477	Major facilitator Superfamily
E3O41_RS00215	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E3O41_RS00225	COG2111	Na H antiporter
E3O41_RS00225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3O41_RS00230	COG1006	Multisubunit Na H antiporter MnhC subunit
E3O41_RS00235	COG0651	ATP synthesis coupled electron transport
E3O41_RS00250	COG1320	monovalent cation:proton antiporter activity
E3O41_RS00270	COG0747	negative chemotaxis
E3O41_RS00275	COG0601	transmembrane transport
E3O41_RS00280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3O41_RS00285	COG0444	Belongs to the ABC transporter superfamily
E3O41_RS00290	COG4608	Belongs to the ABC transporter superfamily
E3O41_RS00315	COG1063	alcohol dehydrogenase
E3O41_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS00330	COG1402	creatininase
E3O41_RS00345	COG0583	DNA-binding transcription factor activity
E3O41_RS00355	COG0656	L-ascorbic acid biosynthetic process
E3O41_RS00360	COG1737	Transcriptional regulator
E3O41_RS00370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3O41_RS00380	COG1178	ABC-type Fe3 transport system permease component
E3O41_RS00385	COG3842	ATPase activity
E3O41_RS00400	COG1522	sequence-specific DNA binding
E3O41_RS00415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3O41_RS00415	COG1796	DNA polymerase
E3O41_RS00430	COG0137	argininosuccinate synthase activity
E3O41_RS00470	COG0714	Associated with various cellular activities
E3O41_RS00495	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E3O41_RS00500	COG2801	Transposase and inactivated derivatives
E3O41_RS00500	COG3415	Transposase
E3O41_RS00515	COG2801	Transposase and inactivated derivatives
E3O41_RS00515	COG3415	Transposase
E3O41_RS00525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3O41_RS00535	COG1605	Chorismate mutase
E3O41_RS00535	COG0287	Prephenate dehydrogenase
E3O41_RS00550	COG1131	(ABC) transporter
E3O41_RS00560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3O41_RS00565	COG1609	Transcriptional regulator
E3O41_RS00575	COG3842	ATPase activity
E3O41_RS00580	COG1178	ABC-type Fe3 transport system permease component
E3O41_RS00585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3O41_RS00625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E3O41_RS00640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3O41_RS00660	COG3265	gluconokinase activity
E3O41_RS00685	COG0535	radical SAM domain protein
E3O41_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS00795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3O41_RS00805	COG4608	Belongs to the ABC transporter superfamily
E3O41_RS00835	COG2801	Transposase and inactivated derivatives
E3O41_RS00835	COG3415	Transposase
E3O41_RS00865	COG0360	Binds together with S18 to 16S ribosomal RNA
E3O41_RS00875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3O41_RS00880	COG0359	binds to the 23S rRNA
E3O41_RS00895	COG0305	Participates in initiation and elongation during chromosome replication
E3O41_RS00905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3O41_RS00930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3O41_RS00940	COG0484	heat shock protein binding
E3O41_RS00995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3O41_RS01010	COG1950	PFAM Membrane protein of
E3O41_RS01020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3O41_RS01025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3O41_RS01035	COG0022	dehydrogenase e1 component
E3O41_RS01040	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3O41_RS01050	COG1121	(ABC) transporter
E3O41_RS01065	COG0701	Predicted permease
E3O41_RS01080	COG2094	Belongs to the DNA glycosylase MPG family
E3O41_RS01085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3O41_RS01090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3O41_RS01095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3O41_RS01110	COG0776	regulation of translation
E3O41_RS01115	COG3336	cytochrome c oxidase
E3O41_RS01125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3O41_RS01175	COG0717	Belongs to the dCTP deaminase family
E3O41_RS01180	COG0395	ABC-type sugar transport system, permease component
E3O41_RS01200	COG3012	SEC-C Motif Domain Protein
E3O41_RS01220	COG0443	Heat shock 70 kDa protein
E3O41_RS01225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3O41_RS01230	COG0484	heat shock protein binding
E3O41_RS01235	COG0789	Transcriptional regulator
E3O41_RS01245	COG0058	SHG alpha-glucan phosphorylase activity
E3O41_RS01255	COG0395	ABC-type sugar transport system, permease component
E3O41_RS01260	COG1653	transport
E3O41_RS01265	COG0366	Alpha amylase catalytic
E3O41_RS01270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3O41_RS01285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3O41_RS01290	COG2252	PERMEase
E3O41_RS01300	COG1953	Uracil, thiamine, allantoin
E3O41_RS01310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3O41_RS01325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3O41_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS01340	COG1846	Transcriptional regulator
E3O41_RS01340	COG1940	carbohydrate kinase activity
E3O41_RS01345	COG1940	carbohydrate kinase activity
E3O41_RS01350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3O41_RS01355	COG0047	phosphoribosylformylglycinamidine synthase activity
E3O41_RS01375	COG0395	ABC-type sugar transport system, permease component
E3O41_RS01380	COG2723	6-phospho-beta-galactosidase activity
E3O41_RS01390	COG2233	PERMEase
E3O41_RS01395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3O41_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS01400	COG3321	synthase
E3O41_RS01400	COG0604	alcohol dehydrogenase
E3O41_RS01415	COG1914	H( )-stimulated, divalent metal cation uptake system
E3O41_RS01420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E3O41_RS01425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3O41_RS01430	COG4770	biotin carboxylase activity
E3O41_RS01440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3O41_RS01455	COG4585	Histidine kinase
E3O41_RS01460	COG2197	response regulator
E3O41_RS01470	COG2814	Major facilitator Superfamily
E3O41_RS01475	COG0151	Belongs to the GarS family
E3O41_RS01495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3O41_RS01530	COG0789	Transcriptional regulator
E3O41_RS01550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3O41_RS01555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3O41_RS01560	COG2017	converts alpha-aldose to the beta-anomer
E3O41_RS01600	COG0513	Belongs to the DEAD box helicase family
E3O41_RS01610	COG1122	ATPase activity
E3O41_RS01620	COG1741	Belongs to the pirin family
E3O41_RS01670	COG0631	protein serine/threonine phosphatase activity
E3O41_RS01695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3O41_RS01700	COG1054	Belongs to the UPF0176 family
E3O41_RS01720	COG1063	alcohol dehydrogenase
E3O41_RS01725	COG1070	Carbohydrate kinase
E3O41_RS01730	COG2115	Belongs to the xylose isomerase family
E3O41_RS01740	COG1609	Transcriptional regulator
E3O41_RS01745	COG1653	transport
E3O41_RS01750	COG1175	transmembrane transport
E3O41_RS01760	COG1472	Belongs to the glycosyl hydrolase 3 family
E3O41_RS01765	COG1940	carbohydrate kinase activity
E3O41_RS01770	COG0598	Magnesium transport protein CorA
E3O41_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS01825	COG3328	transposase activity
E3O41_RS01835	COG3328	transposase activity
E3O41_RS01880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3O41_RS01885	COG0037	tRNA processing
E3O41_RS01890	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E3O41_RS01895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3O41_RS01900	COG0302	gtp cyclohydrolase
E3O41_RS01910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3O41_RS01915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3O41_RS01940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3O41_RS01955	COG4829	muconolactone delta-isomerase
E3O41_RS01970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3O41_RS01980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3O41_RS01985	COG0561	phosphatase activity
E3O41_RS01995	COG1316	TRANSCRIPTIONal
E3O41_RS02005	COG4974	Belongs to the 'phage' integrase family
E3O41_RS02020	COG2801	Transposase and inactivated derivatives
E3O41_RS02020	COG3415	Transposase
E3O41_RS02135	COG0785	Cytochrome C biogenesis protein
E3O41_RS02150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3O41_RS02180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3O41_RS02195	COG1230	cation diffusion facilitator family transporter
E3O41_RS02205	COG0629	single-stranded DNA binding
E3O41_RS02255	COG0739	heme binding
E3O41_RS02295	COG3328	transposase activity
E3O41_RS02340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3O41_RS02350	COG0366	Alpha amylase catalytic
E3O41_RS02360	COG3634	alkyl hydroperoxide reductase activity
E3O41_RS02390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3O41_RS02395	COG4605	iron ion homeostasis
E3O41_RS02400	COG4604	ABC transporter, ATP-binding protein
E3O41_RS02420	COG0745	RESPONSE REGULATOR receiver
E3O41_RS02450	COG3415	Transposase
E3O41_RS02450	COG2801	Transposase and inactivated derivatives
E3O41_RS02455	COG2267	carboxylic ester hydrolase activity
E3O41_RS02470	COG0419	ATPase involved in DNA repair
E3O41_RS02515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3O41_RS02515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3O41_RS02520	COG2197	response regulator
E3O41_RS02545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E3O41_RS02550	COG1064	alcohol dehydrogenase
E3O41_RS02555	COG0590	tRNA wobble adenosine to inosine editing
E3O41_RS02575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3O41_RS02595	COG2409	Drug exporters of the RND superfamily
E3O41_RS02600	COG1309	transcriptional regulator
E3O41_RS02610	COG3285	dna ligase
E3O41_RS02610	COG1793	dna ligase
E3O41_RS02615	COG2200	EAL domain
E3O41_RS02620	COG4067	protein conserved in archaea
E3O41_RS02620	COG0189	ligase activity
E3O41_RS02625	COG0189	ligase activity
E3O41_RS02625	COG0569	domain protein
E3O41_RS02635	COG1793	dna ligase
E3O41_RS02650	COG1793	dna ligase
E3O41_RS02655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3O41_RS02660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3O41_RS02700	COG1937	Protein conserved in bacteria
E3O41_RS02705	COG2608	mercury ion transmembrane transporter activity
E3O41_RS02705	COG2217	Heavy metal translocating P-type atpase
E3O41_RS02710	COG2217	Heavy metal translocating P-type atpase
E3O41_RS02735	COG0657	acetylesterase activity
E3O41_RS02740	COG1960	acyl-CoA dehydrogenase activity
E3O41_RS02745	COG0045	succinate-CoA ligase (ADP-forming) activity
E3O41_RS02770	COG0138	bifunctional purine biosynthesis protein purh
E3O41_RS02780	COG2169	Transcriptional regulator
E3O41_RS02780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3O41_RS02795	COG1132	(ABC) transporter
E3O41_RS02810	COG0363	glucosamine-6-phosphate deaminase activity
E3O41_RS02820	COG1940	carbohydrate kinase activity
E3O41_RS02820	COG1846	Transcriptional regulator
E3O41_RS02830	COG1175	transmembrane transport
E3O41_RS02835	COG0395	ABC-type sugar transport system, permease component
E3O41_RS02840	COG1940	carbohydrate kinase activity
E3O41_RS02845	COG0277	FAD linked oxidase domain protein
E3O41_RS02860	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3O41_RS02865	COG3639	organic phosphonate transmembrane transporter activity
E3O41_RS02885	COG3624	Phosphonate C-P lyase system protein PhnG
E3O41_RS02890	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E3O41_RS02895	COG3626	phosphonate metabolism
E3O41_RS02905	COG4778	phosphonate C-P lyase system protein PhnL
E3O41_RS02910	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E3O41_RS02915	COG3454	Phosphonate metabolism
E3O41_RS02920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E3O41_RS02960	COG0714	Associated with various cellular activities
E3O41_RS02975	COG3290	protein histidine kinase activity
E3O41_RS02980	COG1301	dicarboxylic acid transport
E3O41_RS03005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3O41_RS03025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3O41_RS03050	COG0579	oxidoreductase
E3O41_RS03065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3O41_RS03090	COG2808	Putative FMN-binding domain
E3O41_RS03100	COG2205	protein histidine kinase activity
E3O41_RS03105	COG0745	RESPONSE REGULATOR receiver
E3O41_RS03115	COG1061	Type III restriction enzyme res subunit
E3O41_RS03145	COG1278	Cold shock
E3O41_RS03155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3O41_RS03200	COG2197	response regulator
E3O41_RS03210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3O41_RS03215	COG2818	Glycosylase
E3O41_RS03220	COG2169	Transcriptional regulator
E3O41_RS03220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3O41_RS03235	COG1970	mechanosensitive ion channel activity
E3O41_RS03245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3O41_RS03250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3O41_RS03305	COG2733	membrane
E3O41_RS03310	COG1937	Protein conserved in bacteria
E3O41_RS03335	COG1780	Probably involved in ribonucleotide reductase function
E3O41_RS03340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3O41_RS03345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3O41_RS03355	COG2072	flavoprotein involved in K transport
E3O41_RS03365	COG2851	Citrate transporter
E3O41_RS03370	COG3290	protein histidine kinase activity
E3O41_RS03375	COG4565	transcriptional regulatory protein
E3O41_RS03400	COG1595	DNA-templated transcription, initiation
E3O41_RS03410	COG2814	Major facilitator Superfamily
E3O41_RS03415	COG2354	Protein conserved in bacteria
E3O41_RS03420	COG4552	Acetyltransferase involved in intracellular survival and related
E3O41_RS03430	COG0567	Dehydrogenase, E1 component
E3O41_RS03430	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3O41_RS03435	COG1253	flavin adenine dinucleotide binding
E3O41_RS03455	COG1473	amidohydrolase
E3O41_RS03460	COG1902	pentaerythritol trinitrate reductase activity
E3O41_RS03480	COG2814	Major facilitator Superfamily
E3O41_RS03490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3O41_RS03505	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E3O41_RS03510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E3O41_RS03520	COG1063	alcohol dehydrogenase
E3O41_RS03545	COG0444	Belongs to the ABC transporter superfamily
E3O41_RS03550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3O41_RS03560	COG0747	negative chemotaxis
E3O41_RS03565	COG0596	Alpha beta hydrolase
E3O41_RS03565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3O41_RS03570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3O41_RS03575	COG0667	Aldo Keto reductase
E3O41_RS03595	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E3O41_RS03600	COG1506	peptidase
E3O41_RS03600	COG0823	Involved in the tonB-independent uptake of proteins
E3O41_RS03610	COG1132	(ABC) transporter
E3O41_RS03625	COG4172	Belongs to the ABC transporter superfamily
E3O41_RS03630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3O41_RS03635	COG0601	transmembrane transport
E3O41_RS03640	COG0747	negative chemotaxis
E3O41_RS03645	COG1012	belongs to the aldehyde dehydrogenase family
E3O41_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS03665	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3O41_RS03670	COG1129	ABC transporter
E3O41_RS03675	COG1063	alcohol dehydrogenase
E3O41_RS03680	COG3958	Transketolase
E3O41_RS03685	COG3959	Transketolase, thiamine diphosphate binding domain
E3O41_RS03700	COG2186	Transcriptional regulator
E3O41_RS03730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3O41_RS03735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3O41_RS03740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3O41_RS03755	COG0477	Major facilitator Superfamily
E3O41_RS03765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3O41_RS03770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3O41_RS03770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3O41_RS03785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3O41_RS03795	COG0180	Tryptophanyl-tRNA synthetase
E3O41_RS03805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3O41_RS03810	COG1053	succinate dehydrogenase
E3O41_RS03820	COG2009	succinate dehydrogenase
E3O41_RS03840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3O41_RS03850	COG0246	Mannitol dehydrogenase
E3O41_RS03855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3O41_RS03855	COG2213	PTS system mannitol-specific
E3O41_RS03860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3O41_RS03865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3O41_RS03880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3O41_RS03885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3O41_RS03900	COG4770	biotin carboxylase activity
E3O41_RS03905	COG0424	maF-like protein
E3O41_RS03910	COG0018	arginyl-trna synthetase
E3O41_RS03920	COG0019	diaminopimelate decarboxylase activity
E3O41_RS03925	COG0460	homoserine dehydrogenase
E3O41_RS03930	COG0083	homoserine kinase activity
E3O41_RS03940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3O41_RS03945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3O41_RS03975	COG1045	serine acetyltransferase
E3O41_RS03985	COG2890	protein-(glutamine-N5) methyltransferase activity
E3O41_RS03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3O41_RS04005	COG0356	it plays a direct role in the translocation of protons across the membrane
E3O41_RS04015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3O41_RS04020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3O41_RS04025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3O41_RS04030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3O41_RS04035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3O41_RS04040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3O41_RS04045	COG3022	response to hydroperoxide
E3O41_RS04060	COG1674	ftsk spoiiie
E3O41_RS04085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3O41_RS04090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3O41_RS04095	COG0750	zinc metalloprotease
E3O41_RS04105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3O41_RS04110	COG0454	-acetyltransferase
E3O41_RS04120	COG0384	phenazine biosynthesis protein PhzF
E3O41_RS04130	COG0640	Transcriptional regulator
E3O41_RS04140	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E3O41_RS04145	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E3O41_RS04160	COG0442	prolyl-tRNA aminoacylation
E3O41_RS04170	COG1115	amino acid carrier protein
E3O41_RS04175	COG0195	Participates in both transcription termination and antitermination
E3O41_RS04185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3O41_RS04190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3O41_RS04195	COG3559	Exporter of polyketide antibiotics
E3O41_RS04200	COG1131	(ABC) transporter
E3O41_RS04205	COG1194	a g-specific adenine glycosylase
E3O41_RS04215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3O41_RS04230	COG0196	riboflavin kinase activity
E3O41_RS04240	COG2217	Heavy metal translocating P-type atpase
E3O41_RS04270	COG1063	alcohol dehydrogenase
E3O41_RS04275	COG1879	ABC-type sugar transport system periplasmic component
E3O41_RS04290	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3O41_RS04295	COG1129	ABC transporter
E3O41_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS04310	COG2140	Oxalate decarboxylase
E3O41_RS04315	COG0800	Aldolase
E3O41_RS04330	COG1737	Transcriptional regulator
E3O41_RS04345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3O41_RS04355	COG0438	transferase activity, transferring glycosyl groups
E3O41_RS04360	COG0789	Transcriptional regulator
E3O41_RS04420	COG0542	response to heat
E3O41_RS04430	COG1053	succinate dehydrogenase
E3O41_RS04450	COG1012	belongs to the aldehyde dehydrogenase family
E3O41_RS04455	COG0583	DNA-binding transcription factor activity
E3O41_RS04470	COG2838	Isocitrate dehydrogenase
E3O41_RS04490	COG1643	Atp-dependent helicase
E3O41_RS04510	COG3639	organic phosphonate transmembrane transporter activity
E3O41_RS04520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3O41_RS04540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3O41_RS04545	COG0084	hydrolase, TatD family'
E3O41_RS04550	COG0488	(ABC) transporter
E3O41_RS04560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3O41_RS04565	COG0667	Aldo Keto reductase
E3O41_RS04570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3O41_RS04580	COG0517	IMP dehydrogenase activity
E3O41_RS04580	COG1125	glycine betaine transport
E3O41_RS04585	COG1174	glycine betaine transport
E3O41_RS04595	COG1732	Glycine betaine
E3O41_RS04600	COG1609	Transcriptional regulator
E3O41_RS04610	COG4214	carbohydrate transport
E3O41_RS04625	COG1132	(ABC) transporter
E3O41_RS04645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3O41_RS04650	COG1122	ATPase activity
E3O41_RS04655	COG0488	(ABC) transporter
E3O41_RS04685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3O41_RS04690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3O41_RS04700	COG2205	protein histidine kinase activity
E3O41_RS04705	COG0745	RESPONSE REGULATOR receiver
E3O41_RS04715	COG1136	(ABC) transporter
E3O41_RS04725	COG1476	TRANSCRIPTIONal
E3O41_RS04740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E3O41_RS04745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3O41_RS04750	COG0193	aminoacyl-tRNA hydrolase activity
E3O41_RS04760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3O41_RS04770	COG0124	histidyl-tRNA synthetase
E3O41_RS04790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3O41_RS04805	COG4122	O-methyltransferase activity
E3O41_RS04810	COG0148	phosphopyruvate hydratase activity
E3O41_RS04825	COG1404	Belongs to the peptidase S8 family
E3O41_RS04855	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3O41_RS04860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3O41_RS04865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3O41_RS04880	COG1338	Plays a role in the flagellum-specific transport system
E3O41_RS04890	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3O41_RS04890	COG1776	CheC inhibitor of MCP methylation
E3O41_RS04920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3O41_RS04935	COG1157	protein secretion by the type III secretion system
E3O41_RS04945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3O41_RS04950	COG1766	The M ring may be actively involved in energy transduction
E3O41_RS04965	COG1815	bacterial-type flagellum-dependent cell motility
E3O41_RS04985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3O41_RS05000	COG1256	bacterial-type flagellum assembly
E3O41_RS05000	COG4786	Flagellar basal body rod
E3O41_RS05025	COG2124	cytochrome p450
E3O41_RS05040	COG0723	plastoquinol--plastocyanin reductase activity
E3O41_RS05055	COG2910	NAD(P)H-binding
E3O41_RS05080	COG0477	Major facilitator Superfamily
E3O41_RS05085	COG2884	Cell division ATP-binding protein ftsE
E3O41_RS05090	COG2177	Part of the ABC transporter FtsEX involved in
E3O41_RS05095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3O41_RS05120	COG2971	BadF BadG BcrA BcrD
E3O41_RS05130	COG2372	response to copper ion
E3O41_RS05135	COG1716	ATPase activity
E3O41_RS05150	COG1192	Involved in chromosome partitioning
E3O41_RS05170	COG0564	pseudouridine synthase activity
E3O41_RS05180	COG1704	LemA family
E3O41_RS05195	COG3214	Protein conserved in bacteria
E3O41_RS05210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3O41_RS05215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3O41_RS05235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3O41_RS05245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E3O41_RS05250	COG1505	serine-type exopeptidase activity
E3O41_RS05255	COG3415	Transposase
E3O41_RS05255	COG2801	Transposase and inactivated derivatives
E3O41_RS05260	COG1966	Carbon starvation protein
E3O41_RS05275	COG0114	fumarate hydratase activity
E3O41_RS05280	COG0288	reversible hydration of carbon dioxide
E3O41_RS05290	COG1722	exodeoxyribonuclease VII activity
E3O41_RS05295	COG1570	exodeoxyribonuclease VII activity
E3O41_RS05300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3O41_RS05315	COG0191	fructose-bisphosphate aldolase activity
E3O41_RS05330	COG1322	Protein conserved in bacteria
E3O41_RS05335	COG2176	DNA-directed DNA polymerase activity
E3O41_RS05340	COG3104	oligopeptide transport
E3O41_RS05345	COG0012	GTP binding
E3O41_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS05385	COG0385	Bile acid
E3O41_RS05405	COG2378	regulation of single-species biofilm formation
E3O41_RS05430	COG1228	amidohydrolase
E3O41_RS05435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3O41_RS05455	COG0693	protein deglycase activity
E3O41_RS05460	COG2814	Major facilitator Superfamily
E3O41_RS05465	COG1132	(ABC) transporter
E3O41_RS05480	COG1464	Belongs to the NlpA lipoprotein family
E3O41_RS05485	COG2011	ABC-type metal ion transport system permease component
E3O41_RS05490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3O41_RS05495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3O41_RS05500	COG0509	glycine decarboxylation via glycine cleavage system
E3O41_RS05505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3O41_RS05505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3O41_RS05510	COG0494	nUDIX hydrolase
E3O41_RS05535	COG4166	transmembrane transport
E3O41_RS05540	COG0601	transmembrane transport
E3O41_RS05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3O41_RS05560	COG1217	gtp-binding protein TYPA
E3O41_RS05595	COG2171	N-acyltransferase activity
E3O41_RS05600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3O41_RS05620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3O41_RS05635	COG2239	Acts as a magnesium transporter
E3O41_RS05645	COG0006	proline dipeptidase activity
E3O41_RS05660	COG0613	PHP domain protein
E3O41_RS05665	COG0513	Belongs to the DEAD box helicase family
E3O41_RS05720	COG3480	Lon protease (S16) C-terminal proteolytic domain
E3O41_RS05725	COG1615	UPF0182 protein
E3O41_RS05740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3O41_RS05750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3O41_RS05760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3O41_RS05775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E3O41_RS05780	COG1737	Transcriptional regulator
E3O41_RS05790	COG1175	transmembrane transport
E3O41_RS05795	COG0395	ABC-type sugar transport system, permease component
E3O41_RS05800	COG1472	Belongs to the glycosyl hydrolase 3 family
E3O41_RS05820	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E3O41_RS05830	COG0129	dihydroxy-acid dehydratase activity
E3O41_RS05845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3O41_RS05860	COG4948	Mandelate Racemase Muconate Lactonizing
E3O41_RS05870	COG0765	amino acid transport
E3O41_RS05930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3O41_RS05945	COG0539	negative regulation of cytoplasmic translation
E3O41_RS05960	COG0601	transmembrane transport
E3O41_RS05965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3O41_RS05995	COG0237	dephospho-CoA kinase activity
E3O41_RS06000	COG0556	nucleotide-excision repair
E3O41_RS06015	COG1846	Transcriptional regulator
E3O41_RS06025	COG0322	excinuclease ABC activity
E3O41_RS06030	COG1660	Displays ATPase and GTPase activities
E3O41_RS06035	COG1481	regulation of sporulation
E3O41_RS06040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3O41_RS06050	COG0126	phosphoglycerate kinase activity
E3O41_RS06055	COG0149	triose-phosphate isomerase activity
E3O41_RS06060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3O41_RS06070	COG0363	glucosamine-6-phosphate deaminase activity
E3O41_RS06085	COG0166	Belongs to the GPI family
E3O41_RS06090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3O41_RS06100	COG0109	protoheme IX farnesyltransferase activity
E3O41_RS06105	COG0477	Major facilitator Superfamily
E3O41_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
E3O41_RS06120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3O41_RS06125	COG0154	amidase activity
E3O41_RS06130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3O41_RS06135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3O41_RS06155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3O41_RS06170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3O41_RS06180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3O41_RS06185	COG0629	single-stranded DNA binding
E3O41_RS06205	COG4176	ABC-type proline glycine betaine transport system permease component
E3O41_RS06210	COG4175	Glycine betaine
E3O41_RS06210	COG0517	IMP dehydrogenase activity
E3O41_RS06225	COG0822	iron-sulfur transferase activity
E3O41_RS06230	COG1946	Acyl-CoA thioesterase
E3O41_RS06245	COG0668	transmembrane transport
E3O41_RS06255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3O41_RS06260	COG0698	ribose 5-phosphate isomerase
E3O41_RS06265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3O41_RS06275	COG0783	Belongs to the Dps family
E3O41_RS06295	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3O41_RS06300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3O41_RS06305	COG0740	serine-type endopeptidase activity
E3O41_RS06310	COG0740	serine-type endopeptidase activity
E3O41_RS06315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3O41_RS06320	COG0339	signal peptide processing
E3O41_RS06330	COG0525	valine-tRNA ligase activity
E3O41_RS06340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3O41_RS06345	COG0285	dihydrofolate synthase activity
E3O41_RS06355	COG0105	UTP biosynthetic process
E3O41_RS06360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3O41_RS06365	COG0632	four-way junction helicase activity
E3O41_RS06370	COG2255	four-way junction helicase activity
E3O41_RS06380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3O41_RS06385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3O41_RS06390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3O41_RS06400	COG1196	nuclear chromosome segregation
E3O41_RS06420	COG0577	efflux transmembrane transporter activity
E3O41_RS06420	COG1136	(ABC) transporter
E3O41_RS06425	COG0577	efflux transmembrane transporter activity
E3O41_RS06430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3O41_RS06440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3O41_RS06445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3O41_RS06450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3O41_RS06460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3O41_RS06465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3O41_RS06470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3O41_RS06475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3O41_RS06480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3O41_RS06485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E3O41_RS06490	COG0540	Belongs to the ATCase OTCase family
E3O41_RS06495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3O41_RS06505	COG0505	Belongs to the CarA family
E3O41_RS06510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3O41_RS06515	COG0284	orotidine-5'-phosphate decarboxylase activity
E3O41_RS06520	COG0194	GDP metabolic process
E3O41_RS06525	COG1758	RNA polymerase activity
E3O41_RS06530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3O41_RS06540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3O41_RS06550	COG0738	Major facilitator superfamily
E3O41_RS06555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3O41_RS06560	COG0140	phosphoribosyl-ATP diphosphatase activity
E3O41_RS06565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3O41_RS06570	COG0107	imidazoleglycerol-phosphate synthase activity
E3O41_RS06575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3O41_RS06590	COG0134	indole-3-glycerol-phosphate synthase activity
E3O41_RS06595	COG0133	tryptophan synthase activity
E3O41_RS06600	COG0159	tryptophan synthase activity
E3O41_RS06610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3O41_RS06615	COG0070	glutamate synthase
E3O41_RS06615	COG0069	glutamate synthase activity
E3O41_RS06615	COG0067	glutamate synthase
E3O41_RS06625	COG0469	pyruvate kinase activity
E3O41_RS06640	COG2050	protein possibly involved in aromatic compounds catabolism
E3O41_RS06655	COG0477	Major facilitator Superfamily
E3O41_RS06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3O41_RS06685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E3O41_RS06735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3O41_RS06750	COG2391	methyltransferase activity
E3O41_RS06755	COG0425	Belongs to the sulfur carrier protein TusA family
E3O41_RS06780	COG2197	response regulator
E3O41_RS06785	COG4585	Histidine kinase
E3O41_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS06845	COG0110	maltose O-acetyltransferase activity
E3O41_RS06850	COG0438	transferase activity, transferring glycosyl groups
E3O41_RS06870	COG2244	polysaccharide biosynthetic process
E3O41_RS06875	COG1215	transferase activity, transferring glycosyl groups
E3O41_RS06900	COG0318	PFAM AMP-dependent synthetase and ligase
E3O41_RS06910	COG2091	lysine biosynthetic process via aminoadipic acid
E3O41_RS06940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3O41_RS06955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3O41_RS06960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3O41_RS06965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3O41_RS06980	COG1672	PFAM Archaeal ATPase
E3O41_RS06980	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3O41_RS06985	COG2197	response regulator
E3O41_RS06985	COG3903	Transcriptional regulator
E3O41_RS07000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3O41_RS07015	COG0584	glycerophosphoryl diester phosphodiesterase
E3O41_RS07025	COG4608	Belongs to the ABC transporter superfamily
E3O41_RS07030	COG0358	DNA primase activity
E3O41_RS07045	COG0386	Belongs to the glutathione peroxidase family
E3O41_RS07055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3O41_RS07060	COG1381	Involved in DNA repair and RecF pathway recombination
E3O41_RS07075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3O41_RS07085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3O41_RS07095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3O41_RS07105	COG0537	adenosine 5'-monophosphoramidase activity
E3O41_RS07115	COG0484	heat shock protein binding
E3O41_RS07120	COG1420	regulation of RNA biosynthetic process
E3O41_RS07135	COG0481	GTPase activity
E3O41_RS07140	COG0747	negative chemotaxis
E3O41_RS07145	COG0601	transmembrane transport
E3O41_RS07165	COG0268	Binds directly to 16S ribosomal RNA
E3O41_RS07185	COG0495	leucyl-tRNA aminoacylation
E3O41_RS07190	COG0586	Pfam SNARE associated Golgi protein
E3O41_RS07200	COG1362	aminopeptidase activity
E3O41_RS07210	COG1472	Belongs to the glycosyl hydrolase 3 family
E3O41_RS07215	COG0494	nUDIX hydrolase
E3O41_RS07220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3O41_RS07225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3O41_RS07240	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3O41_RS07255	COG0315	cyclic pyranopterin monophosphate synthase activity
E3O41_RS07280	COG0315	cyclic pyranopterin monophosphate synthase activity
E3O41_RS07280	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3O41_RS07295	COG2089	acid synthase
E3O41_RS07300	COG1083	cytidylyl-transferase
E3O41_RS07315	COG0515	serine threonine protein kinase
E3O41_RS07335	COG2207	Transcriptional regulator
E3O41_RS07335	COG3708	Transcriptional regulator
E3O41_RS07365	COG0799	negative regulation of ribosome biogenesis
E3O41_RS07375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3O41_RS07385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3O41_RS07390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3O41_RS07395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3O41_RS07400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3O41_RS07405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3O41_RS07415	COG1530	ribonuclease E activity
E3O41_RS07425	COG0217	transcriptional regulatory protein
E3O41_RS07430	COG0436	Aminotransferase
E3O41_RS07435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3O41_RS07440	COG0482	sulfurtransferase activity
E3O41_RS07450	COG3118	belongs to the thioredoxin family
E3O41_RS07490	COG0233	cytoplasmic translational termination
E3O41_RS07495	COG0528	UMP kinase activity
E3O41_RS07500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3O41_RS07505	COG0052	Belongs to the universal ribosomal protein uS2 family
E3O41_RS07535	COG4974	Belongs to the 'phage' integrase family
E3O41_RS07575	COG0640	Transcriptional regulator
E3O41_RS07590	COG0792	nuclease activity
E3O41_RS07600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3O41_RS07605	COG0681	Belongs to the peptidase S26 family
E3O41_RS07610	COG0335	large ribosomal subunit rRNA binding
E3O41_RS07620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3O41_RS07630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3O41_RS07630	COG1648	precorrin-2 dehydrogenase activity
E3O41_RS07650	COG0336	Belongs to the RNA methyltransferase TrmD family
E3O41_RS07655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3O41_RS07660	COG1837	Belongs to the UPF0109 family
E3O41_RS07665	COG0228	four-way junction DNA binding
E3O41_RS07675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3O41_RS07680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3O41_RS07685	COG1120	ATPase activity
E3O41_RS07695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E3O41_RS07700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3O41_RS07710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E3O41_RS07710	COG2755	lipolytic protein G-D-S-L family
E3O41_RS07740	COG0321	lipoyl(octanoyl) transferase activity
E3O41_RS07745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3O41_RS07750	COG0747	negative chemotaxis
E3O41_RS07765	COG4172	Belongs to the ABC transporter superfamily
E3O41_RS07780	COG0552	protein localization to endoplasmic reticulum
E3O41_RS07785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3O41_RS07790	COG0297	glycogen (starch) synthase activity
E3O41_RS07800	COG2813	Specifically methylates the guanine in position
E3O41_RS07805	COG1196	nuclear chromosome segregation
E3O41_RS07825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3O41_RS07835	COG2205	protein histidine kinase activity
E3O41_RS07840	COG0745	RESPONSE REGULATOR receiver
E3O41_RS07850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3O41_RS07855	COG0571	ribonuclease III activity
E3O41_RS07860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3O41_RS07870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3O41_RS07880	COG0742	ribosomal rna small subunit methyltransferase
E3O41_RS07890	COG1476	TRANSCRIPTIONal
E3O41_RS07910	COG0587	DNA-directed DNA polymerase activity
E3O41_RS07915	COG2135	peptidase activity
E3O41_RS07935	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3O41_RS07940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3O41_RS07950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3O41_RS07955	COG0066	3-isopropylmalate dehydratase activity
E3O41_RS07960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3O41_RS08005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3O41_RS08010	COG4336	lyase activity
E3O41_RS08015	COG2814	Major facilitator Superfamily
E3O41_RS08020	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3O41_RS08025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3O41_RS08030	COG0473	3-isopropylmalate dehydrogenase activity
E3O41_RS08035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3O41_RS08050	COG4129	membrane
E3O41_RS08055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3O41_RS08065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3O41_RS08070	COG1845	cytochrome c oxidase, subunit III
E3O41_RS08075	COG2010	Cytochrome c
E3O41_RS08080	COG0723	plastoquinol--plastocyanin reductase activity
E3O41_RS08085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3O41_RS08090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3O41_RS08135	COG0586	Pfam SNARE associated Golgi protein
E3O41_RS08140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E3O41_RS08150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3O41_RS08155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3O41_RS08160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3O41_RS08185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3O41_RS08200	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3O41_RS08205	COG0789	Transcriptional regulator
E3O41_RS08215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E3O41_RS08220	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E3O41_RS08235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3O41_RS08245	COG4221	oxidoreductase activity
E3O41_RS08270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3O41_RS08350	COG1024	Enoyl-CoA hydratase
E3O41_RS08350	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3O41_RS08360	COG3655	Transcriptional regulator
E3O41_RS08365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3O41_RS08370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3O41_RS08385	COG0756	dUTP diphosphatase activity
E3O41_RS08410	COG3415	Transposase
E3O41_RS08410	COG2801	Transposase and inactivated derivatives
E3O41_RS08420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3O41_RS08430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3O41_RS08440	COG0187	DNA topoisomerase II activity
E3O41_RS08450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3O41_RS08465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3O41_RS08475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3O41_RS08480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3O41_RS08485	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3O41_RS08505	COG0174	glutamine synthetase
E3O41_RS08510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3O41_RS08535	COG0805	protein transport
E3O41_RS08540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3O41_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3O41_RS08575	COG1968	undecaprenyl-diphosphatase activity
E3O41_RS08580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3O41_RS08600	COG0183	Belongs to the thiolase family
E3O41_RS08640	COG0406	alpha-ribazole phosphatase activity
E3O41_RS08645	COG1522	sequence-specific DNA binding
E3O41_RS08660	COG0254	rRNA binding
E3O41_RS08665	COG1119	ATPase activity
E3O41_RS08670	COG0560	Phosphoserine phosphatase
E3O41_RS08675	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS08700	COG0488	(ABC) transporter
E3O41_RS08710	COG1472	Belongs to the glycosyl hydrolase 3 family
E3O41_RS08730	COG1215	transferase activity, transferring glycosyl groups
E3O41_RS08740	COG1253	flavin adenine dinucleotide binding
E3O41_RS08745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3O41_RS08750	COG1122	ATPase activity
E3O41_RS08755	COG1268	BioY protein
E3O41_RS08765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3O41_RS08770	COG2151	metal-sulfur cluster biosynthetic enzyme
E3O41_RS08775	COG0396	ATPase activity
E3O41_RS08785	COG0719	Fe-S assembly protein
E3O41_RS08820	COG0483	inositol monophosphate 1-phosphatase activity
E3O41_RS08840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3O41_RS08850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E3O41_RS08860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3O41_RS08865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3O41_RS08885	COG0167	dihydroorotate dehydrogenase activity
E3O41_RS08890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3O41_RS08895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3O41_RS08925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3O41_RS08930	COG3599	regulation of cell shape
E3O41_RS08940	COG1799	cell septum assembly
E3O41_RS08960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3O41_RS08965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3O41_RS08970	COG0772	Belongs to the SEDS family
E3O41_RS08975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3O41_RS08980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3O41_RS08990	COG0768	penicillin binding
E3O41_RS09000	COG0275	rRNA processing
E3O41_RS09005	COG2001	Belongs to the MraZ family
E3O41_RS09015	COG0142	geranyltranstransferase activity
E3O41_RS09025	COG1388	LysM domain
E3O41_RS09025	COG0791	NLP P60 protein
E3O41_RS09030	COG0515	serine threonine protein kinase
E3O41_RS09030	COG2815	serine threonine protein kinase
E3O41_RS09035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E3O41_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS09070	COG1764	response to oxidative stress
E3O41_RS09080	COG1573	uracil-dna glycosylase
E3O41_RS09090	COG0531	amino acid
E3O41_RS09110	COG2814	Major facilitator Superfamily
E3O41_RS09125	COG1160	GTP binding
E3O41_RS09130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3O41_RS09135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3O41_RS09135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3O41_RS09145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3O41_RS09150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3O41_RS09170	COG0504	CTP synthase activity
E3O41_RS09175	COG0497	DNA recombination
E3O41_RS09180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3O41_RS09190	COG0647	UMP catabolic process
E3O41_RS09220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3O41_RS09225	COG0165	Argininosuccinate lyase
E3O41_RS09235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3O41_RS09240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3O41_RS09245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3O41_RS09250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3O41_RS09255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3O41_RS09260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3O41_RS09270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3O41_RS09270	COG0072	phenylalanine-tRNA ligase activity
E3O41_RS09275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3O41_RS09280	COG0765	amino acid transport
E3O41_RS09285	COG0765	amino acid transport
E3O41_RS09290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3O41_RS09295	COG1126	abc transporter atp-binding protein
E3O41_RS09300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3O41_RS09305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3O41_RS09310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3O41_RS09315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3O41_RS09330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3O41_RS09335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3O41_RS09340	COG0131	Imidazoleglycerol-phosphate dehydratase
E3O41_RS09345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3O41_RS09355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3O41_RS09370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3O41_RS09375	COG2813	Specifically methylates the guanine in position
E3O41_RS09380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3O41_RS09385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3O41_RS09390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3O41_RS09400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3O41_RS09410	COG1396	sequence-specific DNA binding
E3O41_RS09415	COG1058	Belongs to the CinA family
E3O41_RS09415	COG1546	Belongs to the CinA family
E3O41_RS09425	COG1674	ftsk spoiiie
E3O41_RS09430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E3O41_RS09435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3O41_RS09445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3O41_RS09475	COG1079	Belongs to the binding-protein-dependent transport system permease family
E3O41_RS09480	COG4603	Belongs to the binding-protein-dependent transport system permease family
E3O41_RS09485	COG3845	ABC transporter
E3O41_RS09495	COG1957	nucleoside hydrolase
E3O41_RS09510	COG1185	polyribonucleotide nucleotidyltransferase activity
E3O41_RS09540	COG3594	Acyltransferase
E3O41_RS09545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3O41_RS09560	COG0545	Peptidyl-prolyl cis-trans isomerase
E3O41_RS09570	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3O41_RS09580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3O41_RS09605	COG0653	protein targeting
E3O41_RS09615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3O41_RS09645	COG5401	PFAM Sporulation and spore germination
E3O41_RS09650	COG5002	protein histidine kinase activity
E3O41_RS09655	COG0745	RESPONSE REGULATOR receiver
E3O41_RS09675	COG0714	Associated with various cellular activities
E3O41_RS09750	COG1216	Glycosyl transferase, family 2
E3O41_RS09815	COG2755	lipolytic protein G-D-S-L family
E3O41_RS09815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E3O41_RS09825	COG1215	transferase activity, transferring glycosyl groups
E3O41_RS09895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3O41_RS09900	COG1335	isochorismatase
E3O41_RS09910	COG1396	sequence-specific DNA binding
E3O41_RS09920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3O41_RS09930	COG0702	epimerase
E3O41_RS09950	COG0470	DNA polymerase III
E3O41_RS09955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3O41_RS09960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3O41_RS09960	COG1754	DNA topoisomerase type I activity
E3O41_RS09990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3O41_RS10005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3O41_RS10010	COG1408	metallophosphoesterase
E3O41_RS10030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3O41_RS10035	COG1435	thymidine kinase activity
E3O41_RS10040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3O41_RS10040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3O41_RS10050	COG0459	protein refolding
E3O41_RS10075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3O41_RS10090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3O41_RS10090	COG2080	2 iron, 2 sulfur cluster binding
E3O41_RS10095	COG3608	succinylglutamate desuccinylase aspartoacylase
E3O41_RS10095	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3O41_RS10100	COG0590	tRNA wobble adenosine to inosine editing
E3O41_RS10115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3O41_RS10125	COG0402	S-adenosylhomocysteine deaminase activity
E3O41_RS10130	COG1609	Transcriptional regulator
E3O41_RS10135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3O41_RS10140	COG1116	anion transmembrane transporter activity
E3O41_RS10150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3O41_RS10155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3O41_RS10165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3O41_RS10195	COG3842	ATPase activity
E3O41_RS10210	COG1733	regulation of RNA biosynthetic process
E3O41_RS10215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3O41_RS10220	COG0215	cysteine-tRNA ligase activity
E3O41_RS10225	COG0697	spore germination
E3O41_RS10230	COG3415	Transposase
E3O41_RS10230	COG2801	Transposase and inactivated derivatives
E3O41_RS10235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E3O41_RS10235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3O41_RS10250	COG0745	RESPONSE REGULATOR receiver
E3O41_RS10265	COG0588	phosphoglycerate mutase activity
E3O41_RS10285	COG0354	folic acid binding
E3O41_RS10290	COG4044	May play a role in the intracellular transport of hydrophobic ligands
E3O41_RS10300	COG0745	RESPONSE REGULATOR receiver
E3O41_RS10305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3O41_RS10310	COG0406	alpha-ribazole phosphatase activity
E3O41_RS10310	COG0494	nUDIX hydrolase
E3O41_RS10335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3O41_RS10360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3O41_RS10385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3O41_RS10425	COG0471	metal ion transport
E3O41_RS10455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3O41_RS10460	COG1053	succinate dehydrogenase
E3O41_RS10475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3O41_RS10500	COG1842	Phage shock protein A
E3O41_RS10520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3O41_RS10525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3O41_RS10530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3O41_RS10540	COG0039	L-malate dehydrogenase activity
E3O41_RS10560	COG0395	ABC-type sugar transport system, permease component
E3O41_RS10565	COG1175	transmembrane transport
E3O41_RS10580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3O41_RS10590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3O41_RS10605	COG0222	ribosome binding
E3O41_RS10610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3O41_RS10620	COG0477	Major facilitator Superfamily
E3O41_RS10630	COG0604	alcohol dehydrogenase
E3O41_RS10630	COG3321	synthase
E3O41_RS10645	COG0081	regulation of translation
E3O41_RS10650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3O41_RS10670	COG1012	belongs to the aldehyde dehydrogenase family
E3O41_RS10690	COG0436	Aminotransferase
E3O41_RS10700	COG2610	gluconate transmembrane transporter activity
E3O41_RS10705	COG2084	Dehydrogenase
E3O41_RS10720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3O41_RS10730	COG2030	dehydratase
E3O41_RS10735	COG0730	response to heat
E3O41_RS10740	COG3706	GGDEF domain
E3O41_RS10755	COG3979	chitinase
E3O41_RS10760	COG3447	MASE1 domain protein
E3O41_RS10760	COG5001	Diguanylate cyclase
E3O41_RS10760	COG5002	protein histidine kinase activity
E3O41_RS10765	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3O41_RS10780	COG0739	heme binding
E3O41_RS10800	COG1666	GTP binding
E3O41_RS10820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3O41_RS10825	COG3639	organic phosphonate transmembrane transporter activity
E3O41_RS10830	COG3639	organic phosphonate transmembrane transporter activity
E3O41_RS10850	COG0318	PFAM AMP-dependent synthetase and ligase
E3O41_RS10855	COG3833	ABC-type maltose transport systems, permease component
E3O41_RS10860	COG1175	transmembrane transport
E3O41_RS10865	COG2182	Extracellular solute-binding protein
E3O41_RS10870	COG0366	Alpha amylase catalytic
E3O41_RS10875	COG1609	Transcriptional regulator
E3O41_RS10895	COG0142	geranyltranstransferase activity
E3O41_RS10900	COG2226	methyltransferase
E3O41_RS10905	COG1169	isochorismate synthase
E3O41_RS10910	COG1929	Belongs to the glycerate kinase type-1 family
E3O41_RS10915	COG2326	polyphosphate kinase activity
E3O41_RS10920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E3O41_RS10935	COG1575	Belongs to the MenA family. Type 1 subfamily
E3O41_RS10950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3O41_RS10970	COG4948	Mandelate Racemase Muconate Lactonizing
E3O41_RS10980	COG1802	Transcriptional regulator
E3O41_RS10990	COG0584	glycerophosphoryl diester phosphodiesterase
E3O41_RS11000	COG0740	serine-type endopeptidase activity
E3O41_RS11005	COG0740	serine-type endopeptidase activity
E3O41_RS11015	COG0438	transferase activity, transferring glycosyl groups
E3O41_RS11020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3O41_RS11020	COG0519	Catalyzes the synthesis of GMP from XMP
E3O41_RS11035	COG0516	GMP reductase activity
E3O41_RS11070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3O41_RS11085	COG0785	Cytochrome C biogenesis protein
E3O41_RS11095	COG0406	alpha-ribazole phosphatase activity
E3O41_RS11125	COG0833	amino acid
E3O41_RS11135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3O41_RS11140	COG1012	belongs to the aldehyde dehydrogenase family
E3O41_RS11150	COG2186	Transcriptional regulator
E3O41_RS11155	COG0586	Pfam SNARE associated Golgi protein
E3O41_RS11165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3O41_RS11170	COG1090	epimerase
E3O41_RS11195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3O41_RS11235	COG0640	Transcriptional regulator
E3O41_RS11240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3O41_RS11245	COG0569	domain protein
E3O41_RS11260	COG0569	domain protein
E3O41_RS11265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3O41_RS11280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3O41_RS11325	COG0802	atpase or kinase
E3O41_RS11330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3O41_RS11335	COG0736	holo-[acyl-carrier-protein] synthase activity
E3O41_RS11340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3O41_RS11345	COG1072	(Pantothenic acid kinase))
E3O41_RS11350	COG0248	Ppx GppA phosphatase
E3O41_RS11355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3O41_RS11360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3O41_RS11365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3O41_RS11375	COG0101	tRNA pseudouridine synthase activity
E3O41_RS11380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3O41_RS11385	COG1414	Transcriptional regulator
E3O41_RS11395	COG2031	fatty acid transporter
E3O41_RS11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3O41_RS11410	COG0824	Thioesterase
E3O41_RS11420	COG0659	secondary active sulfate transmembrane transporter activity
E3O41_RS11425	COG0203	ribosomal protein L17
E3O41_RS11430	COG0202	RNA polymerase activity
E3O41_RS11435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3O41_RS11440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3O41_RS11450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3O41_RS11460	COG0024	Methionine aminopeptidase
E3O41_RS11465	COG0563	adenylate kinase activity
E3O41_RS11475	COG0200	Binds to the 23S rRNA
E3O41_RS11480	COG1841	ribosomal large subunit assembly
E3O41_RS11485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3O41_RS11490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3O41_RS11495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3O41_RS11500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3O41_RS11505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3O41_RS11510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3O41_RS11515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3O41_RS11520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3O41_RS11525	COG0255	Belongs to the universal ribosomal protein uL29 family
E3O41_RS11530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3O41_RS11535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3O41_RS11540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3O41_RS11545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3O41_RS11550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3O41_RS11555	COG0089	rRNA binding
E3O41_RS11560	COG0088	Forms part of the polypeptide exit tunnel
E3O41_RS11565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3O41_RS11570	COG0051	transcription antitermination factor activity, RNA binding
E3O41_RS11580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3O41_RS11605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3O41_RS11610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3O41_RS11615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3O41_RS11620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3O41_RS11625	COG2089	acid synthase
E3O41_RS11640	COG1083	cytidylyl-transferase
E3O41_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS11675	COG1088	dTDP-glucose 4,6-dehydratase activity
E3O41_RS11685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3O41_RS11690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3O41_RS11695	COG0049	tRNA binding
E3O41_RS11700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3O41_RS11735	COG0714	Associated with various cellular activities
E3O41_RS11775	COG1131	(ABC) transporter
E3O41_RS11780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3O41_RS11785	COG0085	RNA polymerase activity
E3O41_RS11790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3O41_RS11815	COG3135	benzoate transporter
E3O41_RS11840	COG0577	efflux transmembrane transporter activity
E3O41_RS11840	COG1136	(ABC) transporter
E3O41_RS11845	COG2197	response regulator
E3O41_RS11850	COG4585	Histidine kinase
E3O41_RS11860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3O41_RS11885	COG1201	RNA secondary structure unwinding
E3O41_RS11890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3O41_RS11920	COG1309	transcriptional regulator
E3O41_RS11935	COG0733	neurotransmitter:sodium symporter activity
E3O41_RS11940	COG2357	RelA SpoT domain protein
E3O41_RS11945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3O41_RS11980	COG1175	transmembrane transport
E3O41_RS11985	COG0395	ABC-type sugar transport system, permease component
E3O41_RS11990	COG4941	Belongs to the sigma-70 factor family
E3O41_RS12010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3O41_RS12015	COG0640	Transcriptional regulator
E3O41_RS12025	COG1247	-acetyltransferase
E3O41_RS12035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3O41_RS12040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3O41_RS12045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3O41_RS12065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3O41_RS12100	COG0477	Major facilitator Superfamily
E3O41_RS12125	COG4681	YaeQ
E3O41_RS12160	COG0477	Major facilitator Superfamily
E3O41_RS12165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3O41_RS12175	COG1876	peptidase activity
E3O41_RS12185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3O41_RS12190	COG0456	acetyltransferase
E3O41_RS12200	COG1301	dicarboxylic acid transport
E3O41_RS12210	COG0025	NhaP-type Na H and K H
E3O41_RS12215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3O41_RS12240	COG0628	permease
E3O41_RS12260	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3O41_RS12265	COG0095	Lipoate-protein ligase
E3O41_RS12270	COG2267	carboxylic ester hydrolase activity
E3O41_RS12280	COG2814	Major facilitator Superfamily
E3O41_RS12285	COG3458	cephalosporin-C deacetylase activity
E3O41_RS12295	COG1305	Transglutaminase-like
E3O41_RS12310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3O41_RS12315	COG1834	amidinotransferase
E3O41_RS12320	COG1674	ftsk spoiiie
E3O41_RS12420	COG1012	belongs to the aldehyde dehydrogenase family
E3O41_RS12430	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E3O41_RS12430	COG0778	Nitroreductase
E3O41_RS12440	COG0039	L-malate dehydrogenase activity
E3O41_RS12445	COG0737	Belongs to the 5'-nucleotidase family
E3O41_RS12445	COG4085	toxin activity
E3O41_RS12445	COG1525	nuclease
E3O41_RS12455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3O41_RS12470	COG1739	Uncharacterized protein family UPF0029
E3O41_RS12480	COG1122	ATPase activity
E3O41_RS12485	COG4721	ABC-type cobalt transport system, permease component
E3O41_RS12525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E3O41_RS12530	COG2072	flavoprotein involved in K transport
E3O41_RS12535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3O41_RS12540	COG1920	GTP binding
E3O41_RS12555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3O41_RS12560	COG2801	Transposase and inactivated derivatives
E3O41_RS12560	COG3415	Transposase
E3O41_RS12570	COG0113	porphobilinogen synthase activity
E3O41_RS12580	COG0181	hydroxymethylbilane synthase activity
E3O41_RS12585	COG3253	May function as heme-dependent peroxidase
E3O41_RS12610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3O41_RS12615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3O41_RS12620	COG0436	Aminotransferase
E3O41_RS12650	COG0423	glycine-tRNA ligase activity
E3O41_RS12655	COG1649	PFAM Uncharacterised BCR, COG1649
E3O41_RS12660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3O41_RS12670	COG0477	Major facilitator Superfamily
E3O41_RS12695	COG0673	inositol 2-dehydrogenase activity
E3O41_RS12700	COG1879	ABC-type sugar transport system periplasmic component
E3O41_RS12705	COG1129	ABC transporter
E3O41_RS12710	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3O41_RS12715	COG1940	carbohydrate kinase activity
E3O41_RS12730	COG1414	Transcriptional regulator
E3O41_RS12735	COG0183	Belongs to the thiolase family
E3O41_RS12740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3O41_RS12755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3O41_RS12765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3O41_RS12775	COG3485	protocatechuate 3,4-dioxygenase
E3O41_RS12780	COG1414	Transcriptional regulator
E3O41_RS12785	COG2814	Major facilitator Superfamily
E3O41_RS12795	COG2807	transmembrane transport
E3O41_RS12815	COG1271	oxidase subunit
E3O41_RS12820	COG1294	oxidase, subunit
E3O41_RS12825	COG4988	ABC transporter
E3O41_RS12835	COG2814	Major facilitator Superfamily
E3O41_RS12840	COG1116	anion transmembrane transporter activity
E3O41_RS12845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3O41_RS12850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3O41_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS12875	COG1960	acyl-CoA dehydrogenase activity
E3O41_RS12905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3O41_RS12915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3O41_RS12930	COG3590	peptidase
E3O41_RS12940	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E3O41_RS12950	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E3O41_RS12960	COG1063	alcohol dehydrogenase
E3O41_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS12970	COG0800	Aldolase
E3O41_RS12985	COG0739	heme binding
E3O41_RS13015	COG4585	Histidine kinase
E3O41_RS13045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3O41_RS13055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3O41_RS13060	COG2079	MmgE PrpD family protein
E3O41_RS13065	COG4585	Histidine kinase
E3O41_RS13080	COG4152	abc transporter atp-binding protein
E3O41_RS13085	COG1668	transmembrane transport
E3O41_RS13095	COG0542	response to heat
E3O41_RS13125	COG0438	transferase activity, transferring glycosyl groups
E3O41_RS13135	COG0617	tRNA 3'-terminal CCA addition
E3O41_RS13140	COG1063	alcohol dehydrogenase
E3O41_RS13150	COG3226	Transcriptional regulator
E3O41_RS13155	COG2890	protein-(glutamine-N5) methyltransferase activity
E3O41_RS13175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3O41_RS13185	COG0395	ABC-type sugar transport system, permease component
E3O41_RS13190	COG1175	transmembrane transport
E3O41_RS13195	COG1414	Transcriptional regulator
E3O41_RS13205	COG0492	ferredoxin-NADP+ reductase activity
E3O41_RS13210	COG3118	belongs to the thioredoxin family
E3O41_RS13225	COG3290	protein histidine kinase activity
E3O41_RS13230	COG3181	Tripartite tricarboxylate transporter family receptor
E3O41_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
E3O41_RS13270	COG1192	Involved in chromosome partitioning
E3O41_RS13275	COG0357	Ribosomal RNA small subunit methyltransferase G
E3O41_RS13285	COG0706	membrane insertase activity
E3O41_RS13290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3O41_RS13295	COG0594	ribonuclease P activity
E3O41_RS13300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3O41_RS13340	COG0640	Transcriptional regulator
E3O41_RS13385	COG1333	cytochrome c biogenesis protein
E3O41_RS13390	COG0785	Cytochrome C biogenesis protein
E3O41_RS13405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3O41_RS13415	COG2372	response to copper ion
E3O41_RS13420	COG2072	flavoprotein involved in K transport
E3O41_RS13465	COG1802	Transcriptional regulator
E3O41_RS13505	COG3328	transposase activity
E3O41_RS13515	COG1192	Involved in chromosome partitioning
E3O41_RS13685	COG1737	Transcriptional regulator
E3O41_RS13695	COG3842	ATPase activity
E3O41_RS13710	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3O41_RS13720	COG0395	ABC-type sugar transport system, permease component
E3O41_RS13800	COG3547	Transposase (IS116 IS110 IS902 family)
E3O41_RS13815	COG3547	Transposase (IS116 IS110 IS902 family)
E3O41_RS13835	COG1414	Transcriptional regulator
E3O41_RS13840	COG0656	L-ascorbic acid biosynthetic process
E3O41_RS13885	COG3328	transposase activity
E3O41_RS13910	COG4638	Rieske (2fe-2S)
E3O41_RS13920	COG2801	Transposase and inactivated derivatives
E3O41_RS13930	COG1335	isochorismatase
E3O41_RS13940	COG2801	Transposase and inactivated derivatives
E3O41_RS13965	COG0235	Class ii aldolase
E3O41_RS14005	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E3O41_RS14010	COG4638	Rieske (2fe-2S)