locus-tag	class	description
IM776_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IM776_RS00010	COG0592	DNA-directed DNA polymerase activity
IM776_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IM776_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IM776_RS00025	COG0187	DNA topoisomerase II activity
IM776_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IM776_RS00040	COG4585	Histidine kinase
IM776_RS00045	COG2197	response regulator
IM776_RS00080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IM776_RS00090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IM776_RS00095	COG0494	nUDIX hydrolase
IM776_RS00115	COG0705	Rhomboid family
IM776_RS00125	COG3764	Sortase (surface protein transpeptidase)
IM776_RS00140	COG0515	serine threonine protein kinase
IM776_RS00140	COG2815	serine threonine protein kinase
IM776_RS00145	COG0515	serine threonine protein kinase
IM776_RS00150	COG0768	penicillin binding
IM776_RS00165	COG1716	ATPase activity
IM776_RS00170	COG1716	ATPase activity
IM776_RS00180	COG3708	Transcriptional regulator
IM776_RS00180	COG2207	Transcriptional regulator
IM776_RS00190	COG2197	response regulator
IM776_RS00205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IM776_RS00210	COG3237	CsbD-like
IM776_RS00215	COG2409	Drug exporters of the RND superfamily
IM776_RS00220	COG1278	Cold shock
IM776_RS00230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IM776_RS00235	COG0738	Major facilitator superfamily
IM776_RS00240	COG1609	Transcriptional regulator
IM776_RS00245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IM776_RS00245	COG2111	Na H antiporter
IM776_RS00250	COG1006	Multisubunit Na H antiporter MnhC subunit
IM776_RS00255	COG0651	ATP synthesis coupled electron transport
IM776_RS00265	COG2212	antiporter activity
IM776_RS00270	COG1320	monovalent cation:proton antiporter activity
IM776_RS00285	COG1126	abc transporter atp-binding protein
IM776_RS00290	COG0765	amino acid transport
IM776_RS00295	COG0765	amino acid transport
IM776_RS00315	COG0137	argininosuccinate synthase activity
IM776_RS00330	COG0142	geranyltranstransferase activity
IM776_RS00355	COG0702	epimerase
IM776_RS00360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IM776_RS00410	COG0714	Associated with various cellular activities
IM776_RS00415	COG1595	DNA-templated transcription, initiation
IM776_RS00430	COG2267	carboxylic ester hydrolase activity
IM776_RS00440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IM776_RS00450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IM776_RS00460	COG1125	glycine betaine transport
IM776_RS00460	COG0517	IMP dehydrogenase activity
IM776_RS00465	COG1174	glycine betaine transport
IM776_RS00490	COG1605	Chorismate mutase
IM776_RS00490	COG0287	Prephenate dehydrogenase
IM776_RS00500	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IM776_RS00505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IM776_RS00510	COG3639	organic phosphonate transmembrane transporter activity
IM776_RS00520	COG1309	transcriptional regulator
IM776_RS00570	COG1131	(ABC) transporter
IM776_RS00595	COG1131	(ABC) transporter
IM776_RS00600	COG1309	transcriptional regulator
IM776_RS00605	COG2813	Specifically methylates the guanine in position
IM776_RS00610	COG0517	IMP dehydrogenase activity
IM776_RS00610	COG4175	Glycine betaine
IM776_RS00615	COG4176	ABC-type proline glycine betaine transport system permease component
IM776_RS00635	COG0366	Alpha amylase catalytic
IM776_RS00640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IM776_RS00665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IM776_RS00680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IM776_RS00720	COG1175	transmembrane transport
IM776_RS00725	COG0395	ABC-type sugar transport system, permease component
IM776_RS00735	COG1482	cell wall glycoprotein biosynthetic process
IM776_RS00750	COG0590	tRNA wobble adenosine to inosine editing
IM776_RS00795	COG1309	transcriptional regulator
IM776_RS00830	COG2815	serine threonine protein kinase
IM776_RS00830	COG0515	serine threonine protein kinase
IM776_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS00850	COG3250	beta-galactosidase activity
IM776_RS00855	COG0395	ABC-type sugar transport system, permease component
IM776_RS00885	COG0583	DNA-binding transcription factor activity
IM776_RS00890	COG4948	Mandelate Racemase Muconate Lactonizing
IM776_RS00895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM776_RS00905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS00915	COG0747	negative chemotaxis
IM776_RS00920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IM776_RS00925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM776_RS00935	COG4948	Mandelate Racemase Muconate Lactonizing
IM776_RS00940	COG3655	Transcriptional regulator
IM776_RS00950	COG0738	Major facilitator superfamily
IM776_RS00970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IM776_RS00975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IM776_RS00980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IM776_RS00995	COG1695	Transcriptional regulator
IM776_RS01000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IM776_RS01040	COG1175	transmembrane transport
IM776_RS01050	COG3622	Belongs to the hyi family
IM776_RS01100	COG1940	carbohydrate kinase activity
IM776_RS01105	COG0673	inositol 2-dehydrogenase activity
IM776_RS01120	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM776_RS01130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM776_RS01135	COG2159	amidohydrolase
IM776_RS01140	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM776_RS01145	COG0477	Major facilitator Superfamily
IM776_RS01165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IM776_RS01170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IM776_RS01175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IM776_RS01185	COG1309	transcriptional regulator
IM776_RS01190	COG0328	RNA-DNA hybrid ribonuclease activity
IM776_RS01240	COG1914	H( )-stimulated, divalent metal cation uptake system
IM776_RS01245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM776_RS01250	COG1609	Transcriptional regulator
IM776_RS01275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IM776_RS01285	COG1940	carbohydrate kinase activity
IM776_RS01295	COG1175	transmembrane transport
IM776_RS01300	COG0395	ABC-type sugar transport system, permease component
IM776_RS01330	COG1090	epimerase
IM776_RS01335	COG0813	purine-nucleoside phosphorylase activity
IM776_RS01340	COG1120	ATPase activity
IM776_RS01360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM776_RS01365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM776_RS01370	COG1120	ATPase activity
IM776_RS01400	COG1175	transmembrane transport
IM776_RS01405	COG3833	ABC-type maltose transport systems, permease component
IM776_RS01410	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IM776_RS01415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IM776_RS01425	COG1672	PFAM Archaeal ATPase
IM776_RS01425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IM776_RS01440	COG0531	amino acid
IM776_RS01450	COG0789	Transcriptional regulator
IM776_RS01455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IM776_RS01460	COG2357	RelA SpoT domain protein
IM776_RS01490	COG0601	transmembrane transport
IM776_RS01495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS01500	COG1472	Belongs to the glycosyl hydrolase 3 family
IM776_RS01505	COG0659	secondary active sulfate transmembrane transporter activity
IM776_RS01510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IM776_RS01515	COG2197	response regulator
IM776_RS01520	COG4585	Histidine kinase
IM776_RS01530	COG1609	Transcriptional regulator
IM776_RS01535	COG0366	Alpha amylase catalytic
IM776_RS01550	COG0047	phosphoribosylformylglycinamidine synthase activity
IM776_RS01565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IM776_RS01575	COG1175	transmembrane transport
IM776_RS01580	COG0395	ABC-type sugar transport system, permease component
IM776_RS01585	COG2723	6-phospho-beta-galactosidase activity
IM776_RS01605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IM776_RS01620	COG2514	catechol 2,3-dioxygenase activity
IM776_RS01630	COG1914	H( )-stimulated, divalent metal cation uptake system
IM776_RS01635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IM776_RS01640	COG4336	lyase activity
IM776_RS01645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IM776_RS01650	COG4770	biotin carboxylase activity
IM776_RS01660	COG2233	PERMEase
IM776_RS01665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IM776_RS01685	COG4585	Histidine kinase
IM776_RS01720	COG1129	ABC transporter
IM776_RS01725	COG1172	Belongs to the binding-protein-dependent transport system permease family
IM776_RS01730	COG1940	carbohydrate kinase activity
IM776_RS01735	COG0151	Belongs to the GarS family
IM776_RS01750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IM776_RS01755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM776_RS01760	COG4558	Periplasmic binding protein
IM776_RS01785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IM776_RS01820	COG0789	Transcriptional regulator
IM776_RS01830	COG0778	Nitroreductase
IM776_RS01845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IM776_RS01850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IM776_RS01860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IM776_RS01865	COG2017	converts alpha-aldose to the beta-anomer
IM776_RS01870	COG0513	Belongs to the DEAD box helicase family
IM776_RS01890	COG0395	ABC-type sugar transport system, permease component
IM776_RS01895	COG1175	transmembrane transport
IM776_RS01900	COG1653	transport
IM776_RS01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM776_RS01920	COG0673	inositol 2-dehydrogenase activity
IM776_RS01925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM776_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS01960	COG1063	alcohol dehydrogenase
IM776_RS01970	COG1960	acyl-CoA dehydrogenase activity
IM776_RS01985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IM776_RS01990	COG1122	ATPase activity
IM776_RS02015	COG0514	ATP-dependent DNA helicase (RecQ)
IM776_RS02035	COG2818	Glycosylase
IM776_RS02045	COG0714	Associated with various cellular activities
IM776_RS02065	COG0631	protein serine/threonine phosphatase activity
IM776_RS02140	COG3210	domain, Protein
IM776_RS02175	COG0039	L-malate dehydrogenase activity
IM776_RS02195	COG2211	Major facilitator Superfamily
IM776_RS02205	COG0463	Glycosyl transferase, family 2
IM776_RS02230	COG0154	amidase activity
IM776_RS02255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IM776_RS02270	COG2188	Transcriptional regulator
IM776_RS02340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IM776_RS02350	COG0037	tRNA processing
IM776_RS02360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IM776_RS02365	COG0302	gtp cyclohydrolase
IM776_RS02370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IM776_RS02375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IM776_RS02380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IM776_RS02410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IM776_RS02425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IM776_RS02435	COG1597	lipid kinase activity
IM776_RS02440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IM776_RS02445	COG0561	phosphatase activity
IM776_RS02455	COG1316	TRANSCRIPTIONal
IM776_RS02460	COG2190	(PTS) system
IM776_RS02460	COG1263	PTS System
IM776_RS02460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IM776_RS02465	COG1609	Transcriptional regulator
IM776_RS02470	COG0366	Alpha amylase catalytic
IM776_RS02480	COG1175	transmembrane transport
IM776_RS02485	COG0395	ABC-type sugar transport system, permease component
IM776_RS02490	COG1070	Carbohydrate kinase
IM776_RS02495	COG3347	Dehydrogenase
IM776_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS02500	COG2814	Major facilitator Superfamily
IM776_RS02540	COG1192	Involved in chromosome partitioning
IM776_RS02585	COG0628	permease
IM776_RS02610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IM776_RS02625	COG3328	transposase activity
IM776_RS02670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM776_RS02675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM776_RS02725	COG0629	single-stranded DNA binding
IM776_RS02745	COG1192	Involved in chromosome partitioning
IM776_RS02770	COG0739	heme binding
IM776_RS02795	COG0492	ferredoxin-NADP+ reductase activity
IM776_RS02800	COG3118	belongs to the thioredoxin family
IM776_RS02805	COG0798	PFAM Bile acid sodium symporter
IM776_RS02810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM776_RS02815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM776_RS02855	COG2217	Heavy metal translocating P-type atpase
IM776_RS02860	COG1937	Protein conserved in bacteria
IM776_RS02890	COG0640	Transcriptional regulator
IM776_RS02900	COG2072	flavoprotein involved in K transport
IM776_RS02915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IM776_RS02965	COG0739	heme binding
IM776_RS02985	COG0785	Cytochrome C biogenesis protein
IM776_RS03020	COG2133	pyrroloquinoline quinone binding
IM776_RS03060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IM776_RS03075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM776_RS03080	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IM776_RS03090	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS03105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IM776_RS03135	COG0747	negative chemotaxis
IM776_RS03140	COG0601	transmembrane transport
IM776_RS03145	COG0444	Belongs to the ABC transporter superfamily
IM776_RS03155	COG1473	amidohydrolase
IM776_RS03175	COG3483	tryptophan 2,3-dioxygenase activity
IM776_RS03185	COG1309	transcriptional regulator
IM776_RS03210	COG1362	aminopeptidase activity
IM776_RS03240	COG1063	alcohol dehydrogenase
IM776_RS03270	COG0765	amino acid transport
IM776_RS03295	COG0542	response to heat
IM776_RS03310	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IM776_RS03315	COG3639	organic phosphonate transmembrane transporter activity
IM776_RS03335	COG1201	RNA secondary structure unwinding
IM776_RS03345	COG0488	(ABC) transporter
IM776_RS03390	COG1522	sequence-specific DNA binding
IM776_RS03460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IM776_RS03470	COG2326	polyphosphate kinase activity
IM776_RS03485	COG2226	methyltransferase
IM776_RS03490	COG0142	geranyltranstransferase activity
IM776_RS03505	COG1666	GTP binding
IM776_RS03510	COG2182	Extracellular solute-binding protein
IM776_RS03515	COG1175	transmembrane transport
IM776_RS03520	COG3833	ABC-type maltose transport systems, permease component
IM776_RS03545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IM776_RS03550	COG0049	tRNA binding
IM776_RS03555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IM776_RS03560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IM776_RS03570	COG0051	transcription antitermination factor activity, RNA binding
IM776_RS03575	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IM776_RS03580	COG0088	Forms part of the polypeptide exit tunnel
IM776_RS03585	COG0089	rRNA binding
IM776_RS03590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IM776_RS03595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IM776_RS03600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IM776_RS03605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IM776_RS03610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IM776_RS03615	COG0255	Belongs to the universal ribosomal protein uL29 family
IM776_RS03620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IM776_RS03625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IM776_RS03630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IM776_RS03635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IM776_RS03640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IM776_RS03645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IM776_RS03650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IM776_RS03655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IM776_RS03660	COG1841	ribosomal large subunit assembly
IM776_RS03665	COG0200	Binds to the 23S rRNA
IM776_RS03675	COG0563	adenylate kinase activity
IM776_RS03680	COG0024	Methionine aminopeptidase
IM776_RS03695	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IM776_RS03705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IM776_RS03710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IM776_RS03715	COG0202	RNA polymerase activity
IM776_RS03720	COG0203	ribosomal protein L17
IM776_RS03725	COG0730	response to heat
IM776_RS03730	COG2030	dehydratase
IM776_RS03740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IM776_RS03750	COG0436	Aminotransferase
IM776_RS03755	COG1960	acyl-CoA dehydrogenase activity
IM776_RS03760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IM776_RS03765	COG1396	sequence-specific DNA binding
IM776_RS03800	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS03805	COG2188	Transcriptional regulator
IM776_RS03815	COG2084	Dehydrogenase
IM776_RS03820	COG2610	gluconate transmembrane transporter activity
IM776_RS03825	COG0028	Belongs to the TPP enzyme family
IM776_RS03835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM776_RS03855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IM776_RS03860	COG0081	regulation of translation
IM776_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM776_RS03885	COG0765	amino acid transport
IM776_RS03890	COG1126	abc transporter atp-binding protein
IM776_RS03910	COG0477	Major facilitator Superfamily
IM776_RS03920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IM776_RS03925	COG3387	PFAM Glycoside hydrolase 15-related
IM776_RS03935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IM776_RS03940	COG0222	ribosome binding
IM776_RS03945	COG1609	Transcriptional regulator
IM776_RS03950	COG1653	transport
IM776_RS03955	COG1175	transmembrane transport
IM776_RS03960	COG0395	ABC-type sugar transport system, permease component
IM776_RS03990	COG1316	TRANSCRIPTIONal
IM776_RS04025	COG0714	Associated with various cellular activities
IM776_RS04035	COG0705	Rhomboid family
IM776_RS04050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IM776_RS04055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IM776_RS04070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IM776_RS04075	COG0697	spore germination
IM776_RS04085	COG4585	Histidine kinase
IM776_RS04090	COG2197	response regulator
IM776_RS04105	COG0579	oxidoreductase
IM776_RS04110	COG1435	thymidine kinase activity
IM776_RS04140	COG1408	metallophosphoesterase
IM776_RS04145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM776_RS04145	COG4499	WXG100 protein secretion system (Wss), protein YukC
IM776_RS04160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM776_RS04190	COG1754	DNA topoisomerase type I activity
IM776_RS04190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IM776_RS04195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IM776_RS04200	COG0470	DNA polymerase III
IM776_RS04220	COG1335	isochorismatase
IM776_RS04230	COG1739	Uncharacterized protein family UPF0029
IM776_RS04250	COG2860	membrane
IM776_RS04285	COG0318	PFAM AMP-dependent synthetase and ligase
IM776_RS04290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IM776_RS04315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IM776_RS04320	COG0745	RESPONSE REGULATOR receiver
IM776_RS04330	COG4044	May play a role in the intracellular transport of hydrophobic ligands
IM776_RS04345	COG0588	phosphoglycerate mutase activity
IM776_RS04355	COG5002	protein histidine kinase activity
IM776_RS04375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IM776_RS04375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IM776_RS04385	COG0215	cysteine-tRNA ligase activity
IM776_RS04390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM776_RS04405	COG3842	ATPase activity
IM776_RS04425	COG2365	Tyrosine phosphatase family
IM776_RS04445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IM776_RS04465	COG0459	protein refolding
IM776_RS04475	COG2205	protein histidine kinase activity
IM776_RS04480	COG0745	RESPONSE REGULATOR receiver
IM776_RS04485	COG1061	Type III restriction enzyme res subunit
IM776_RS04510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IM776_RS04545	COG3328	transposase activity
IM776_RS04560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IM776_RS04580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IM776_RS04610	COG1309	transcriptional regulator
IM776_RS04615	COG1064	alcohol dehydrogenase
IM776_RS04635	COG0640	Transcriptional regulator
IM776_RS04655	COG1295	ribonuclease BN
IM776_RS04660	COG0531	amino acid
IM776_RS04675	COG2207	Transcriptional regulator
IM776_RS04700	COG2409	Drug exporters of the RND superfamily
IM776_RS04725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IM776_RS04730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IM776_RS04765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IM776_RS04785	COG0028	Belongs to the TPP enzyme family
IM776_RS04795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IM776_RS04810	COG2986	histidine ammonia-lyase
IM776_RS04815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IM776_RS04820	COG1228	amidohydrolase
IM776_RS04845	COG2733	membrane
IM776_RS04850	COG1937	Protein conserved in bacteria
IM776_RS04860	COG0596	Alpha beta hydrolase
IM776_RS04880	COG1780	Probably involved in ribonucleotide reductase function
IM776_RS04885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM776_RS04890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM776_RS04895	COG0596	Alpha beta hydrolase
IM776_RS04905	COG4989	oxidoreductase activity
IM776_RS04970	COG0601	transmembrane transport
IM776_RS04975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS04990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM776_RS05000	COG1643	Atp-dependent helicase
IM776_RS05015	COG1331	Highly conserved protein containing a thioredoxin domain
IM776_RS05030	COG2226	methyltransferase
IM776_RS05035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IM776_RS05040	COG0084	hydrolase, TatD family'
IM776_RS05050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IM776_RS05055	COG0667	Aldo Keto reductase
IM776_RS05060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IM776_RS05065	COG1609	Transcriptional regulator
IM776_RS05075	COG4214	carbohydrate transport
IM776_RS05090	COG0488	(ABC) transporter
IM776_RS05100	COG0564	pseudouridine synthase activity
IM776_RS05105	COG1846	Transcriptional regulator
IM776_RS05115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IM776_RS05120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IM776_RS05135	COG1017	nitric oxide dioxygenase activity
IM776_RS05135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IM776_RS05140	COG2205	protein histidine kinase activity
IM776_RS05145	COG0745	RESPONSE REGULATOR receiver
IM776_RS05155	COG1136	(ABC) transporter
IM776_RS05155	COG0577	efflux transmembrane transporter activity
IM776_RS05175	COG0395	ABC-type sugar transport system, permease component
IM776_RS05180	COG4948	Mandelate Racemase Muconate Lactonizing
IM776_RS05185	COG0800	Aldolase
IM776_RS05190	COG1063	alcohol dehydrogenase
IM776_RS05205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IM776_RS05210	COG0193	aminoacyl-tRNA hydrolase activity
IM776_RS05220	COG0180	Tryptophanyl-tRNA synthetase
IM776_RS05235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IM776_RS05250	COG2009	succinate dehydrogenase
IM776_RS05260	COG1744	ABC transporter substrate-binding protein PnrA-like
IM776_RS05265	COG3845	ABC transporter
IM776_RS05275	COG1079	Belongs to the binding-protein-dependent transport system permease family
IM776_RS05290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IM776_RS05310	COG0385	Bile acid
IM776_RS05315	COG2072	flavoprotein involved in K transport
IM776_RS05320	COG0246	Mannitol dehydrogenase
IM776_RS05330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IM776_RS05350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM776_RS05360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IM776_RS05400	COG0659	secondary active sulfate transmembrane transporter activity
IM776_RS05410	COG0628	permease
IM776_RS05415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IM776_RS05480	COG4770	biotin carboxylase activity
IM776_RS05485	COG0424	maF-like protein
IM776_RS05490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM776_RS05495	COG2197	response regulator
IM776_RS05510	COG1940	carbohydrate kinase activity
IM776_RS05525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM776_RS05545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IM776_RS05570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IM776_RS05575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IM776_RS05580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IM776_RS05590	COG3285	dna ligase
IM776_RS05590	COG1793	dna ligase
IM776_RS05595	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IM776_RS05600	COG0586	Pfam SNARE associated Golgi protein
IM776_RS05650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IM776_RS05655	COG2884	Cell division ATP-binding protein ftsE
IM776_RS05660	COG2177	Part of the ABC transporter FtsEX involved in
IM776_RS05665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IM776_RS05675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IM776_RS05680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IM776_RS05685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IM776_RS05695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IM776_RS05700	COG0131	Imidazoleglycerol-phosphate dehydratase
IM776_RS05705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IM776_RS05710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IM776_RS05725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IM776_RS05730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IM776_RS05735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IM776_RS05745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM776_RS05750	COG1126	abc transporter atp-binding protein
IM776_RS05755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM776_RS05760	COG0765	amino acid transport
IM776_RS05765	COG0765	amino acid transport
IM776_RS05770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IM776_RS05775	COG0072	phenylalanine-tRNA ligase activity
IM776_RS05775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IM776_RS05790	COG0513	Belongs to the DEAD box helicase family
IM776_RS05840	COG3480	Lon protease (S16) C-terminal proteolytic domain
IM776_RS05845	COG1615	UPF0182 protein
IM776_RS05865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IM776_RS05875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM776_RS05880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IM776_RS05885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IM776_RS05890	COG1215	transferase activity, transferring glycosyl groups
IM776_RS06040	COG1132	(ABC) transporter
IM776_RS06075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IM776_RS06155	COG0735	belongs to the Fur family
IM776_RS06170	COG0714	Associated with various cellular activities
IM776_RS06190	COG0745	RESPONSE REGULATOR receiver
IM776_RS06195	COG5000	phosphorelay sensor kinase activity
IM776_RS06195	COG5002	protein histidine kinase activity
IM776_RS06200	COG5401	PFAM Sporulation and spore germination
IM776_RS06225	COG4591	ABC-type transport system involved in lipoprotein release permease component
IM776_RS06225	COG1136	(ABC) transporter
IM776_RS06235	COG0653	protein targeting
IM776_RS06245	COG0489	protein tyrosine kinase activity
IM776_RS06290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IM776_RS06295	COG1595	DNA-templated transcription, initiation
IM776_RS06305	COG4552	Acetyltransferase involved in intracellular survival and related
IM776_RS06310	COG0567	Dehydrogenase, E1 component
IM776_RS06310	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM776_RS06320	COG1253	flavin adenine dinucleotide binding
IM776_RS06330	COG1902	pentaerythritol trinitrate reductase activity
IM776_RS06350	COG2814	Major facilitator Superfamily
IM776_RS06360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IM776_RS06380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IM776_RS06395	COG0444	Belongs to the ABC transporter superfamily
IM776_RS06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS06405	COG0601	transmembrane transport
IM776_RS06410	COG0747	negative chemotaxis
IM776_RS06415	COG0596	Alpha beta hydrolase
IM776_RS06415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IM776_RS06430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IM776_RS06455	COG1842	Phage shock protein A
IM776_RS06470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IM776_RS06495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IM776_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS06515	COG0018	arginyl-trna synthetase
IM776_RS06530	COG0019	diaminopimelate decarboxylase activity
IM776_RS06535	COG0460	homoserine dehydrogenase
IM776_RS06540	COG0083	homoserine kinase activity
IM776_RS06550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IM776_RS06560	COG1045	serine acetyltransferase
IM776_RS06570	COG2890	protein-(glutamine-N5) methyltransferase activity
IM776_RS06580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM776_RS06590	COG0356	it plays a direct role in the translocation of protons across the membrane
IM776_RS06595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM776_RS06600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IM776_RS06605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM776_RS06610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IM776_RS06615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IM776_RS06620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IM776_RS06625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IM776_RS06630	COG3022	response to hydroperoxide
IM776_RS06640	COG0631	protein serine/threonine phosphatase activity
IM776_RS06650	COG0686	Belongs to the AlaDH PNT family
IM776_RS06675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IM776_RS06680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IM776_RS06695	COG0750	zinc metalloprotease
IM776_RS06710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IM776_RS06740	COG0557	exoribonuclease II activity
IM776_RS06745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IM776_RS06750	COG0442	prolyl-tRNA aminoacylation
IM776_RS06755	COG1611	Belongs to the LOG family
IM776_RS06770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IM776_RS06775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IM776_RS06785	COG1194	a g-specific adenine glycosylase
IM776_RS06795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IM776_RS06810	COG0196	riboflavin kinase activity
IM776_RS06815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IM776_RS06850	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM776_RS06860	COG0545	Peptidyl-prolyl cis-trans isomerase
IM776_RS06875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IM776_RS06895	COG3594	Acyltransferase
IM776_RS06925	COG1185	polyribonucleotide nucleotidyltransferase activity
IM776_RS06930	COG0667	Aldo Keto reductase
IM776_RS06960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IM776_RS06975	COG0494	nUDIX hydrolase
IM776_RS06980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM776_RS06985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IM776_RS06990	COG1674	ftsk spoiiie
IM776_RS07000	COG1546	Belongs to the CinA family
IM776_RS07000	COG1058	Belongs to the CinA family
IM776_RS07005	COG1396	sequence-specific DNA binding
IM776_RS07015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IM776_RS07020	COG2137	regulation of response to DNA damage stimulus
IM776_RS07025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IM776_RS07030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IM776_RS07040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IM776_RS07050	COG2813	Specifically methylates the guanine in position
IM776_RS07055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IM776_RS07075	COG0483	inositol monophosphate 1-phosphatase activity
IM776_RS07085	COG0442	prolyl-tRNA aminoacylation
IM776_RS07090	COG2814	Major facilitator Superfamily
IM776_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
IM776_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS07185	COG0129	dihydroxy-acid dehydratase activity
IM776_RS07200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IM776_RS07210	COG1940	carbohydrate kinase activity
IM776_RS07220	COG1175	transmembrane transport
IM776_RS07225	COG0395	ABC-type sugar transport system, permease component
IM776_RS07250	COG0247	lactate metabolic process
IM776_RS07250	COG0277	FAD linked oxidase domain protein
IM776_RS07280	COG0477	Major facilitator Superfamily
IM776_RS07285	COG0473	3-isopropylmalate dehydrogenase activity
IM776_RS07290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IM776_RS07295	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM776_RS07300	COG2814	Major facilitator Superfamily
IM776_RS07305	COG2226	methyltransferase
IM776_RS07310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IM776_RS07330	COG1136	(ABC) transporter
IM776_RS07335	COG1136	(ABC) transporter
IM776_RS07345	COG1278	Cold shock
IM776_RS07400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IM776_RS07405	COG0066	3-isopropylmalate dehydratase activity
IM776_RS07410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IM776_RS07420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IM776_RS07425	COG1181	Belongs to the D-alanine--D-alanine ligase family
IM776_RS07435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IM776_RS07440	COG0742	ribosomal rna small subunit methyltransferase
IM776_RS07450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IM776_RS07460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IM776_RS07465	COG0571	ribonuclease III activity
IM776_RS07470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IM776_RS07475	COG0384	phenazine biosynthesis protein PhzF
IM776_RS07485	COG1136	(ABC) transporter
IM776_RS07505	COG1196	nuclear chromosome segregation
IM776_RS07520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IM776_RS07525	COG0321	lipoyl(octanoyl) transferase activity
IM776_RS07535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IM776_RS07540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IM776_RS07550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IM776_RS07555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IM776_RS07560	COG0228	four-way junction DNA binding
IM776_RS07565	COG1837	Belongs to the UPF0109 family
IM776_RS07570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IM776_RS07575	COG0336	Belongs to the RNA methyltransferase TrmD family
IM776_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS07610	COG0560	Phosphoserine phosphatase
IM776_RS07615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IM776_RS07620	COG0297	glycogen (starch) synthase activity
IM776_RS07625	COG1119	ATPase activity
IM776_RS07630	COG0254	rRNA binding
IM776_RS07650	COG1522	sequence-specific DNA binding
IM776_RS07660	COG0022	dehydrogenase e1 component
IM776_RS07665	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM776_RS07675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM776_RS07685	COG1960	acyl-CoA dehydrogenase activity
IM776_RS07705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IM776_RS07740	COG1968	undecaprenyl-diphosphatase activity
IM776_RS07775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IM776_RS07780	COG0805	protein transport
IM776_RS07785	COG4581	dead DEAH box helicase
IM776_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS07825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IM776_RS07860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IM776_RS07875	COG0477	Major facilitator Superfamily
IM776_RS07920	COG0067	glutamate synthase
IM776_RS07920	COG0069	glutamate synthase activity
IM776_RS07920	COG0070	glutamate synthase
IM776_RS07925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IM776_RS07930	COG0159	tryptophan synthase activity
IM776_RS07935	COG0133	tryptophan synthase activity
IM776_RS07940	COG0134	indole-3-glycerol-phosphate synthase activity
IM776_RS07955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IM776_RS07960	COG0107	imidazoleglycerol-phosphate synthase activity
IM776_RS07965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IM776_RS07970	COG0140	phosphoribosyl-ATP diphosphatase activity
IM776_RS07985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IM776_RS07990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IM776_RS07995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IM776_RS08000	COG1758	RNA polymerase activity
IM776_RS08005	COG0194	GDP metabolic process
IM776_RS08010	COG0284	orotidine-5'-phosphate decarboxylase activity
IM776_RS08015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IM776_RS08020	COG0505	Belongs to the CarA family
IM776_RS08030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IM776_RS08035	COG0540	Belongs to the ATCase OTCase family
IM776_RS08040	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IM776_RS08045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IM776_RS08045	COG2146	nitrite reductase [NAD(P)H] activity
IM776_RS08050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IM776_RS08055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IM776_RS08060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IM776_RS08065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IM776_RS08070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IM776_RS08075	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IM776_RS08080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IM776_RS08085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IM776_RS08095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IM776_RS08100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IM776_RS08110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IM776_RS08140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IM776_RS08140	COG1648	precorrin-2 dehydrogenase activity
IM776_RS08150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IM776_RS08155	COG1196	nuclear chromosome segregation
IM776_RS08165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IM776_RS08170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM776_RS08175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM776_RS08185	COG2255	four-way junction helicase activity
IM776_RS08190	COG0632	four-way junction helicase activity
IM776_RS08195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IM776_RS08200	COG0217	transcriptional regulatory protein
IM776_RS08215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IM776_RS08220	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IM776_RS08230	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IM776_RS08245	COG1917	Cupin 2, conserved barrel domain protein
IM776_RS08250	COG5285	phytanoyl-CoA dioxygenase
IM776_RS08260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IM776_RS08335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IM776_RS08365	COG0183	Belongs to the thiolase family
IM776_RS08370	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM776_RS08370	COG1024	Enoyl-CoA hydratase
IM776_RS08390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IM776_RS08395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IM776_RS08410	COG0756	dUTP diphosphatase activity
IM776_RS08435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IM776_RS08440	COG0187	DNA topoisomerase II activity
IM776_RS08450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IM776_RS08455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IM776_RS08475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IM776_RS08485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IM776_RS08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IM776_RS08495	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM776_RS08510	COG0569	domain protein
IM776_RS08510	COG0189	ligase activity
IM776_RS08515	COG0189	ligase activity
IM776_RS08515	COG4067	protein conserved in archaea
IM776_RS08525	COG0174	glutamine synthetase
IM776_RS08540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IM776_RS08545	COG0174	glutamine synthetase
IM776_RS08575	COG3012	SEC-C Motif Domain Protein
IM776_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS08605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IM776_RS08620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM776_RS08625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IM776_RS08675	COG0783	Belongs to the Dps family
IM776_RS08685	COG2808	Putative FMN-binding domain
IM776_RS08690	COG1115	amino acid carrier protein
IM776_RS08705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IM776_RS08715	COG0668	transmembrane transport
IM776_RS08735	COG1946	Acyl-CoA thioesterase
IM776_RS08770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IM776_RS08780	COG1280	lysine exporter protein (LysE YggA)
IM776_RS08790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IM776_RS08810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IM776_RS08815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IM776_RS08820	COG0154	amidase activity
IM776_RS08825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IM776_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
IM776_RS08840	COG1254	Belongs to the acylphosphatase family
IM776_RS08845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IM776_RS08850	COG0482	sulfurtransferase activity
IM776_RS08865	COG0366	Alpha amylase catalytic
IM776_RS08870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IM776_RS08875	COG3118	belongs to the thioredoxin family
IM776_RS08910	COG0233	cytoplasmic translational termination
IM776_RS08915	COG0528	UMP kinase activity
IM776_RS08920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IM776_RS08925	COG0052	Belongs to the universal ribosomal protein uS2 family
IM776_RS08935	COG4974	Belongs to the 'phage' integrase family
IM776_RS08970	COG0792	nuclease activity
IM776_RS08980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IM776_RS08985	COG0681	Belongs to the peptidase S26 family
IM776_RS08990	COG0335	large ribosomal subunit rRNA binding
IM776_RS09015	COG0488	(ABC) transporter
IM776_RS09025	COG4585	Histidine kinase
IM776_RS09030	COG2197	response regulator
IM776_RS09050	COG2151	metal-sulfur cluster biosynthetic enzyme
IM776_RS09055	COG0396	ATPase activity
IM776_RS09065	COG0719	Fe-S assembly protein
IM776_RS09075	COG1612	heme a metabolic process
IM776_RS09085	COG0109	protoheme IX farnesyltransferase activity
IM776_RS09095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IM776_RS09100	COG0166	Belongs to the GPI family
IM776_RS09115	COG0363	glucosamine-6-phosphate deaminase activity
IM776_RS09145	COG0358	DNA primase activity
IM776_RS09160	COG0386	Belongs to the glutathione peroxidase family
IM776_RS09175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IM776_RS09180	COG1381	Involved in DNA repair and RecF pathway recombination
IM776_RS09185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IM776_RS09200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IM776_RS09210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IM776_RS09220	COG0537	adenosine 5'-monophosphoramidase activity
IM776_RS09235	COG0484	heat shock protein binding
IM776_RS09240	COG1420	regulation of RNA biosynthetic process
IM776_RS09255	COG0481	GTPase activity
IM776_RS09285	COG2211	Major facilitator Superfamily
IM776_RS09295	COG0268	Binds directly to 16S ribosomal RNA
IM776_RS09320	COG0495	leucyl-tRNA aminoacylation
IM776_RS09325	COG0512	Glutamine amidotransferase of anthranilate synthase
IM776_RS09325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IM776_RS09345	COG1472	Belongs to the glycosyl hydrolase 3 family
IM776_RS09385	COG2267	carboxylic ester hydrolase activity
IM776_RS09395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS09400	COG0601	transmembrane transport
IM776_RS09405	COG0747	negative chemotaxis
IM776_RS09420	COG0387	Pfam Sodium calcium exchanger
IM776_RS09450	COG3290	protein histidine kinase activity
IM776_RS09475	COG0799	negative regulation of ribosome biogenesis
IM776_RS09485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IM776_RS09495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IM776_RS09500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IM776_RS09505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IM776_RS09510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IM776_RS09515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IM776_RS09525	COG1530	ribonuclease E activity
IM776_RS09535	COG0105	UTP biosynthetic process
IM776_RS09545	COG0285	dihydrofolate synthase activity
IM776_RS09550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IM776_RS09585	COG1966	Carbon starvation protein
IM776_RS09595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS09605	COG0747	negative chemotaxis
IM776_RS09610	COG0525	valine-tRNA ligase activity
IM776_RS09630	COG0339	signal peptide processing
IM776_RS09640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IM776_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS09655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IM776_RS09660	COG2390	Transcriptional regulator
IM776_RS09665	COG0740	serine-type endopeptidase activity
IM776_RS09670	COG0740	serine-type endopeptidase activity
IM776_RS09680	COG0544	peptidyl-prolyl cis-trans isomerase activity
IM776_RS09705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM776_RS09710	COG0149	triose-phosphate isomerase activity
IM776_RS09715	COG0126	phosphoglycerate kinase activity
IM776_RS09720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IM776_RS09725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IM776_RS09730	COG1481	regulation of sporulation
IM776_RS09735	COG1660	Displays ATPase and GTPase activities
IM776_RS09740	COG0322	excinuclease ABC activity
IM776_RS09760	COG0714	Associated with various cellular activities
IM776_RS09775	COG1846	Transcriptional regulator
IM776_RS09790	COG0556	nucleotide-excision repair
IM776_RS09795	COG2814	Major facilitator Superfamily
IM776_RS09800	COG0237	dephospho-CoA kinase activity
IM776_RS09820	COG0745	RESPONSE REGULATOR receiver
IM776_RS09830	COG5002	protein histidine kinase activity
IM776_RS09835	COG1832	CoA-binding protein
IM776_RS09845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM776_RS09850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IM776_RS09860	COG1116	anion transmembrane transporter activity
IM776_RS09865	COG0539	negative regulation of cytoplasmic translation
IM776_RS09880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IM776_RS09885	COG2807	transmembrane transport
IM776_RS09890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IM776_RS09890	COG1796	DNA polymerase
IM776_RS09895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IM776_RS09900	COG1845	cytochrome c oxidase, subunit III
IM776_RS09905	COG2010	Cytochrome c
IM776_RS09910	COG0723	plastoquinol--plastocyanin reductase activity
IM776_RS09915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IM776_RS09935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM776_RS09940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IM776_RS09960	COG0167	dihydroorotate dehydrogenase activity
IM776_RS09965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IM776_RS09970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IM776_RS09980	COG0587	DNA-directed DNA polymerase activity
IM776_RS10005	COG1309	transcriptional regulator
IM776_RS10015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IM776_RS10030	COG1799	cell septum assembly
IM776_RS10040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IM776_RS10050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IM776_RS10055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM776_RS10065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IM776_RS10070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM776_RS10080	COG0768	penicillin binding
IM776_RS10090	COG0275	rRNA processing
IM776_RS10095	COG2001	Belongs to the MraZ family
IM776_RS10105	COG0142	geranyltranstransferase activity
IM776_RS10115	COG1705	Flagellar rod assembly protein muramidase FlgJ
IM776_RS10115	COG1388	LysM domain
IM776_RS10120	COG0515	serine threonine protein kinase
IM776_RS10120	COG2815	serine threonine protein kinase
IM776_RS10130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IM776_RS10135	COG0204	Acyl-transferase
IM776_RS10140	COG1022	Amp-dependent synthetase and ligase
IM776_RS10160	COG1192	Involved in chromosome partitioning
IM776_RS10175	COG1716	ATPase activity
IM776_RS10180	COG2372	response to copper ion
IM776_RS10200	COG0277	FAD linked oxidase domain protein
IM776_RS10210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM776_RS10215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IM776_RS10220	COG3424	synthase
IM776_RS10235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IM776_RS10250	COG0587	DNA-directed DNA polymerase activity
IM776_RS10265	COG0586	Pfam SNARE associated Golgi protein
IM776_RS10295	COG4249	Peptidase C14 caspase catalytic subunit p20
IM776_RS10315	COG0488	(ABC) transporter
IM776_RS10400	COG1160	GTP binding
IM776_RS10405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IM776_RS10420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IM776_RS10425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IM776_RS10440	COG0494	nUDIX hydrolase
IM776_RS10445	COG0504	CTP synthase activity
IM776_RS10450	COG0497	DNA recombination
IM776_RS10455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IM776_RS10470	COG0647	UMP catabolic process
IM776_RS10500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM776_RS10510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IM776_RS10515	COG0667	Aldo Keto reductase
IM776_RS10535	COG0165	Argininosuccinate lyase
IM776_RS10545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IM776_RS10550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IM776_RS10555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IM776_RS10560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IM776_RS10565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IM776_RS10575	COG0352	thiamine-phosphate diphosphorylase activity
IM776_RS10575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IM776_RS10575	COG0351	phosphomethylpyrimidine kinase
IM776_RS10580	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IM776_RS10595	COG0006	proline dipeptidase activity
IM776_RS10615	COG2239	Acts as a magnesium transporter
IM776_RS10660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM776_RS10665	COG2171	N-acyltransferase activity
IM776_RS10670	COG0513	Belongs to the DEAD box helicase family
IM776_RS10675	COG1131	(ABC) transporter
IM776_RS10690	COG2197	response regulator
IM776_RS10730	COG0477	Major facilitator Superfamily
IM776_RS10735	COG2066	Belongs to the glutaminase family
IM776_RS10740	COG1217	gtp-binding protein TYPA
IM776_RS10765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS10770	COG0601	transmembrane transport
IM776_RS10775	COG4166	transmembrane transport
IM776_RS10780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IM776_RS10780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IM776_RS10785	COG0509	glycine decarboxylation via glycine cleavage system
IM776_RS10790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IM776_RS10800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IM776_RS10805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IM776_RS10815	COG1104	cysteine desulfurase activity
IM776_RS10820	COG0463	Glycosyl transferase, family 2
IM776_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS10830	COG1132	(ABC) transporter
IM776_RS10835	COG2814	Major facilitator Superfamily
IM776_RS10870	COG0693	protein deglycase activity
IM776_RS10890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IM776_RS10895	COG0259	pyridoxamine-phosphate oxidase activity
IM776_RS10900	COG0012	GTP binding
IM776_RS10910	COG2176	DNA-directed DNA polymerase activity
IM776_RS10920	COG1322	Protein conserved in bacteria
IM776_RS10935	COG0191	fructose-bisphosphate aldolase activity
IM776_RS10945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IM776_RS10950	COG1570	exodeoxyribonuclease VII activity
IM776_RS10955	COG1722	exodeoxyribonuclease VII activity
IM776_RS10970	COG0114	fumarate hydratase activity
IM776_RS10980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IM776_RS10990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IM776_RS11020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IM776_RS11025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IM776_RS11035	COG3214	Protein conserved in bacteria
IM776_RS11045	COG1704	LemA family
IM776_RS11075	COG1404	Belongs to the peptidase S8 family
IM776_RS11090	COG0148	phosphopyruvate hydratase activity
IM776_RS11095	COG4122	O-methyltransferase activity
IM776_RS11110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IM776_RS11125	COG2755	lipolytic protein G-D-S-L family
IM776_RS11130	COG0124	histidyl-tRNA synthetase
IM776_RS11140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IM776_RS11145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IM776_RS11150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IM776_RS11175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IM776_RS11190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM776_RS11190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM776_RS11195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IM776_RS11205	COG0477	Major facilitator Superfamily
IM776_RS11210	COG1619	proteins homologs of microcin C7 resistance protein MccF
IM776_RS11220	COG1132	(ABC) transporter
IM776_RS11225	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IM776_RS11250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IM776_RS11255	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IM776_RS11265	COG1737	Transcriptional regulator
IM776_RS11275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IM776_RS11285	COG1175	transmembrane transport
IM776_RS11295	COG1793	dna ligase
IM776_RS11315	COG2197	response regulator
IM776_RS11320	COG4585	Histidine kinase
IM776_RS11330	COG1131	(ABC) transporter
IM776_RS11355	COG0477	Major facilitator Superfamily
IM776_RS11370	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS11380	COG3971	2-oxopent-4-enoate hydratase activity
IM776_RS11400	COG1472	Belongs to the glycosyl hydrolase 3 family
IM776_RS11405	COG0395	ABC-type sugar transport system, permease component
IM776_RS11410	COG1175	transmembrane transport
IM776_RS11415	COG1653	transport
IM776_RS11420	COG1609	Transcriptional regulator
IM776_RS11425	COG2115	Belongs to the xylose isomerase family
IM776_RS11430	COG1070	Carbohydrate kinase
IM776_RS11435	COG0277	FAD linked oxidase domain protein
IM776_RS11440	COG2017	converts alpha-aldose to the beta-anomer
IM776_RS11460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IM776_RS11465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IM776_RS11485	COG0277	FAD linked oxidase domain protein
IM776_RS11495	COG0363	glucosamine-6-phosphate deaminase activity
IM776_RS11500	COG1940	carbohydrate kinase activity
IM776_RS11510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IM776_RS11535	COG2838	Isocitrate dehydrogenase
IM776_RS11545	COG1940	carbohydrate kinase activity
IM776_RS11545	COG1846	Transcriptional regulator
IM776_RS11555	COG3458	cephalosporin-C deacetylase activity
IM776_RS11565	COG1175	transmembrane transport
IM776_RS11570	COG0395	ABC-type sugar transport system, permease component
IM776_RS11580	COG1501	Belongs to the glycosyl hydrolase 31 family
IM776_RS11595	COG1132	(ABC) transporter
IM776_RS11600	COG1132	(ABC) transporter
IM776_RS11615	COG0138	bifunctional purine biosynthesis protein purh
IM776_RS11630	COG2252	PERMEase
IM776_RS11640	COG0045	succinate-CoA ligase (ADP-forming) activity
IM776_RS11645	COG1309	transcriptional regulator
IM776_RS11655	COG1793	dna ligase
IM776_RS11670	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IM776_RS11670	COG2066	Belongs to the glutaminase family
IM776_RS11685	COG3304	Inner membrane component domain
IM776_RS11705	COG0584	glycerophosphoryl diester phosphodiesterase
IM776_RS11715	COG2261	transglycosylase associated protein
IM776_RS11720	COG4941	Belongs to the sigma-70 factor family
IM776_RS11730	COG0438	transferase activity, transferring glycosyl groups
IM776_RS11735	COG0519	Catalyzes the synthesis of GMP from XMP
IM776_RS11735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IM776_RS11750	COG4085	toxin activity
IM776_RS11750	COG0737	Belongs to the 5'-nucleotidase family
IM776_RS11750	COG1525	nuclease
IM776_RS11760	COG0516	GMP reductase activity
IM776_RS11775	COG1172	Belongs to the binding-protein-dependent transport system permease family
IM776_RS11810	COG0443	Heat shock 70 kDa protein
IM776_RS11845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IM776_RS11865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IM776_RS11870	COG0456	acetyltransferase
IM776_RS11885	COG2202	Pas domain
IM776_RS11885	COG2205	protein histidine kinase activity
IM776_RS11890	COG0463	Glycosyl transferase, family 2
IM776_RS11895	COG3979	chitinase
IM776_RS11900	COG0745	RESPONSE REGULATOR receiver
IM776_RS11910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IM776_RS11935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IM776_RS11980	COG1815	bacterial-type flagellum-dependent cell motility
IM776_RS11990	COG1677	Flagellar hook-basal body complex protein FliE
IM776_RS12000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IM776_RS12010	COG1157	protein secretion by the type III secretion system
IM776_RS12025	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IM776_RS12040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IM776_RS12065	COG1338	Plays a role in the flagellum-specific transport system
IM776_RS12080	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IM776_RS12085	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IM776_RS12090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IM776_RS12095	COG0802	atpase or kinase
IM776_RS12100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IM776_RS12105	COG0736	holo-[acyl-carrier-protein] synthase activity
IM776_RS12110	COG4608	Belongs to the ABC transporter superfamily
IM776_RS12115	COG0444	Belongs to the ABC transporter superfamily
IM776_RS12125	COG0601	transmembrane transport
IM776_RS12140	COG1940	carbohydrate kinase activity
IM776_RS12150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IM776_RS12155	COG1072	(Pantothenic acid kinase))
IM776_RS12165	COG0248	Ppx GppA phosphatase
IM776_RS12175	COG2217	Heavy metal translocating P-type atpase
IM776_RS12180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM776_RS12185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM776_RS12195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IM776_RS12200	COG2197	response regulator
IM776_RS12205	COG2211	Major facilitator Superfamily
IM776_RS12235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM776_RS12245	COG0489	protein tyrosine kinase activity
IM776_RS12260	COG0438	transferase activity, transferring glycosyl groups
IM776_RS12265	COG0297	glycogen (starch) synthase activity
IM776_RS12290	COG2244	polysaccharide biosynthetic process
IM776_RS12310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IM776_RS12330	COG5297	Belongs to the glycosyl hydrolase family 6
IM776_RS12330	COG4733	cellulase activity
IM776_RS12350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IM776_RS12350	COG2755	lipolytic protein G-D-S-L family
IM776_RS12355	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IM776_RS12360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IM776_RS12370	COG3206	protein involved in exopolysaccharide biosynthesis
IM776_RS12370	COG0489	protein tyrosine kinase activity
IM776_RS12385	COG0438	transferase activity, transferring glycosyl groups
IM776_RS12400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IM776_RS12405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IM776_RS12410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IM776_RS12415	COG2755	lipolytic protein G-D-S-L family
IM776_RS12415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IM776_RS12420	COG0101	tRNA pseudouridine synthase activity
IM776_RS12430	COG2011	ABC-type metal ion transport system permease component
IM776_RS12445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IM776_RS12480	COG0739	heme binding
IM776_RS12485	COG0483	inositol monophosphate 1-phosphatase activity
IM776_RS12525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IM776_RS12530	COG0085	RNA polymerase activity
IM776_RS12535	COG4172	Belongs to the ABC transporter superfamily
IM776_RS12540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS12545	COG0601	transmembrane transport
IM776_RS12550	COG0747	negative chemotaxis
IM776_RS12555	COG1472	Belongs to the glycosyl hydrolase 3 family
IM776_RS12560	COG0395	ABC-type sugar transport system, permease component
IM776_RS12600	COG1136	(ABC) transporter
IM776_RS12600	COG0577	efflux transmembrane transporter activity
IM776_RS12605	COG2197	response regulator
IM776_RS12610	COG4585	Histidine kinase
IM776_RS12640	COG4948	Mandelate Racemase Muconate Lactonizing
IM776_RS12645	COG1309	transcriptional regulator
IM776_RS12650	COG2409	Drug exporters of the RND superfamily
IM776_RS12665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IM776_RS12675	COG0785	Cytochrome C biogenesis protein
IM776_RS12690	COG3634	alkyl hydroperoxide reductase activity
IM776_RS12695	COG0406	alpha-ribazole phosphatase activity
IM776_RS12705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IM776_RS12730	COG3842	ATPase activity
IM776_RS12735	COG1126	abc transporter atp-binding protein
IM776_RS12740	COG0765	amino acid transport
IM776_RS12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM776_RS12760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM776_RS12790	COG0640	Transcriptional regulator
IM776_RS12795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IM776_RS12800	COG0569	domain protein
IM776_RS12825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IM776_RS12845	COG0667	Aldo Keto reductase
IM776_RS12850	COG0419	ATPase involved in DNA repair
IM776_RS12885	COG4604	ABC transporter, ATP-binding protein
IM776_RS12890	COG4605	iron ion homeostasis
IM776_RS12895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM776_RS12900	COG4607	ABC-type enterochelin transport system periplasmic component
IM776_RS12920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM776_RS12935	COG0583	DNA-binding transcription factor activity
IM776_RS12940	COG1053	succinate dehydrogenase
IM776_RS12950	COG0596	Alpha beta hydrolase
IM776_RS12955	COG1573	uracil-dna glycosylase
IM776_RS12985	COG2514	catechol 2,3-dioxygenase activity
IM776_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS13010	COG1643	Atp-dependent helicase
IM776_RS13020	COG1131	(ABC) transporter
IM776_RS13030	COG1760	l-serine dehydratase
IM776_RS13065	COG0822	iron-sulfur transferase activity
IM776_RS13085	COG3973	AAA domain
IM776_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS13105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IM776_RS13130	COG1546	Belongs to the CinA family
IM776_RS13130	COG1058	Belongs to the CinA family
IM776_RS13175	COG0733	neurotransmitter:sodium symporter activity
IM776_RS13185	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IM776_RS13195	COG3119	arylsulfatase activity
IM776_RS13200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IM776_RS13205	COG3119	arylsulfatase activity
IM776_RS13210	COG3119	arylsulfatase activity
IM776_RS13250	COG0739	heme binding
IM776_RS13285	COG0477	Major facilitator Superfamily
IM776_RS13290	COG4988	ABC transporter
IM776_RS13295	COG4988	ABC transporter
IM776_RS13300	COG1294	oxidase, subunit
IM776_RS13305	COG1271	oxidase subunit
IM776_RS13315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IM776_RS13330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IM776_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS13360	COG3655	Transcriptional regulator
IM776_RS13390	COG0210	DNA helicase
IM776_RS13420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM776_RS13430	COG0077	Prephenate dehydratase
IM776_RS13450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM776_RS13465	COG1175	transmembrane transport
IM776_RS13470	COG0395	ABC-type sugar transport system, permease component
IM776_RS13475	COG1929	Belongs to the glycerate kinase type-1 family
IM776_RS13480	COG1609	Transcriptional regulator
IM776_RS13495	COG0673	inositol 2-dehydrogenase activity
IM776_RS13500	COG1609	Transcriptional regulator
IM776_RS13510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IM776_RS13520	COG2272	Belongs to the type-B carboxylesterase lipase family
IM776_RS13525	COG3265	gluconokinase activity
IM776_RS13530	COG4948	Mandelate Racemase Muconate Lactonizing
IM776_RS13535	COG0246	Mannitol dehydrogenase
IM776_RS13540	COG1904	glucuronate isomerase
IM776_RS13550	COG1609	Transcriptional regulator
IM776_RS13555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IM776_RS13575	COG0803	Belongs to the bacterial solute-binding protein 9 family
IM776_RS13585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM776_RS13590	COG1121	(ABC) transporter
IM776_RS13595	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IM776_RS13600	COG0095	Lipoate-protein ligase
IM776_RS13605	COG2267	carboxylic ester hydrolase activity
IM776_RS13610	COG1846	Transcriptional regulator
IM776_RS13625	COG0477	Major facilitator Superfamily
IM776_RS13635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IM776_RS13640	COG1834	amidinotransferase
IM776_RS13655	COG1476	TRANSCRIPTIONal
IM776_RS13665	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS13685	COG0237	dephospho-CoA kinase activity
IM776_RS13695	COG0318	PFAM AMP-dependent synthetase and ligase
IM776_RS13700	COG0446	pyridine nucleotide-disulphide oxidoreductase
IM776_RS13700	COG1902	pentaerythritol trinitrate reductase activity
IM776_RS13705	COG0183	Belongs to the thiolase family
IM776_RS13730	COG1024	Enoyl-CoA hydratase
IM776_RS13755	COG0183	Belongs to the thiolase family
IM776_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS13765	COG1960	acyl-CoA dehydrogenase activity
IM776_RS13770	COG1024	Enoyl-CoA hydratase
IM776_RS13775	COG1960	acyl-CoA dehydrogenase activity
IM776_RS13780	COG1960	acyl-CoA dehydrogenase activity
IM776_RS13785	COG1960	acyl-CoA dehydrogenase activity
IM776_RS13815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM776_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS13840	COG1309	transcriptional regulator
IM776_RS13845	COG0318	PFAM AMP-dependent synthetase and ligase
IM776_RS13850	COG0183	Belongs to the thiolase family
IM776_RS13885	COG0559	Belongs to the binding-protein-dependent transport system permease family
IM776_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS13915	COG2072	flavoprotein involved in K transport
IM776_RS13935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM776_RS13940	COG0477	Major facilitator Superfamily
IM776_RS13945	COG1902	pentaerythritol trinitrate reductase activity
IM776_RS13965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IM776_RS14020	COG0628	permease
IM776_RS14030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IM776_RS14035	COG2079	MmgE PrpD family protein
IM776_RS14060	COG2140	Oxalate decarboxylase
IM776_RS14070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM776_RS14085	COG1879	ABC-type sugar transport system periplasmic component
IM776_RS14090	COG1172	Belongs to the binding-protein-dependent transport system permease family
IM776_RS14115	COG4948	Mandelate Racemase Muconate Lactonizing
IM776_RS14120	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM776_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS14130	COG3618	amidohydrolase
IM776_RS14140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IM776_RS14145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IM776_RS14150	COG1869	D-ribose catabolic process
IM776_RS14155	COG2188	Transcriptional regulator
IM776_RS14165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IM776_RS14175	COG0667	Aldo Keto reductase
IM776_RS14190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IM776_RS14195	COG0800	Aldolase
IM776_RS14205	COG0300	oxidoreductase activity
IM776_RS14215	COG3189	MarR family transcriptional regulator
IM776_RS14235	COG1122	ATPase activity
IM776_RS14240	COG4721	ABC-type cobalt transport system, permease component
IM776_RS14260	COG1024	Enoyl-CoA hydratase
IM776_RS14275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IM776_RS14290	COG0181	hydroxymethylbilane synthase activity
IM776_RS14295	COG3253	May function as heme-dependent peroxidase
IM776_RS14320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IM776_RS14325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IM776_RS14370	COG0488	(ABC) transporter
IM776_RS14375	COG0423	glycine-tRNA ligase activity
IM776_RS14390	COG0477	Major facilitator Superfamily
IM776_RS14405	COG1846	Transcriptional regulator
IM776_RS14415	COG3590	peptidase
IM776_RS14425	COG0534	Mate efflux family protein
IM776_RS14455	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IM776_RS14465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IM776_RS14505	COG4152	abc transporter atp-binding protein
IM776_RS14510	COG1668	transmembrane transport
IM776_RS14515	COG4166	transmembrane transport
IM776_RS14525	COG0601	transmembrane transport
IM776_RS14530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM776_RS14550	COG1309	transcriptional regulator
IM776_RS14555	COG1024	Enoyl-CoA hydratase
IM776_RS14560	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM776_RS14565	COG2030	dehydratase
IM776_RS14565	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS14570	COG0537	adenosine 5'-monophosphoramidase activity
IM776_RS14580	COG3396	Phenylacetate-CoA oxygenase
IM776_RS14585	COG3460	Phenylacetate-CoA oxygenase
IM776_RS14590	COG3396	Phenylacetate-CoA oxygenase
IM776_RS14595	COG2151	metal-sulfur cluster biosynthetic enzyme
IM776_RS14600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IM776_RS14605	COG1024	Enoyl-CoA hydratase
IM776_RS14610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IM776_RS14615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IM776_RS14620	COG0542	response to heat
IM776_RS14655	COG1396	sequence-specific DNA binding
IM776_RS14665	COG0477	Major facilitator Superfamily
IM776_RS14670	COG0445	tRNA wobble uridine modification
IM776_RS14675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM776_RS14680	COG1024	Enoyl-CoA hydratase
IM776_RS14685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM776_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS14695	COG1012	belongs to the aldehyde dehydrogenase family
IM776_RS14725	COG0640	Transcriptional regulator
IM776_RS14750	COG1070	Carbohydrate kinase
IM776_RS14755	COG1609	Transcriptional regulator
IM776_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS14780	COG2706	6-phosphogluconolactonase activity
IM776_RS14790	COG0395	ABC-type sugar transport system, permease component
IM776_RS14795	COG1175	transmembrane transport
IM776_RS14800	COG1653	transport
IM776_RS14815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM776_RS14845	COG0395	ABC-type sugar transport system, permease component
IM776_RS14850	COG1175	transmembrane transport
IM776_RS14860	COG0235	Class ii aldolase
IM776_RS14865	COG3395	kinase activity
IM776_RS14880	COG3684	Belongs to the aldolase LacD family
IM776_RS14900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM776_RS14915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IM776_RS14940	COG0673	inositol 2-dehydrogenase activity
IM776_RS14945	COG1802	Transcriptional regulator
IM776_RS14950	COG0789	Transcriptional regulator
IM776_RS14955	COG0484	heat shock protein binding
IM776_RS14960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IM776_RS14965	COG0443	Heat shock 70 kDa protein
IM776_RS14975	COG0596	Alpha beta hydrolase
IM776_RS15005	COG2814	Major facilitator Superfamily
IM776_RS15035	COG0717	Belongs to the dCTP deaminase family
IM776_RS15045	COG1960	acyl-CoA dehydrogenase activity
IM776_RS15060	COG0477	Major facilitator Superfamily
IM776_RS15085	COG1129	ABC transporter
IM776_RS15095	COG2186	Transcriptional regulator
IM776_RS15105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IM776_RS15110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IM776_RS15115	COG1116	anion transmembrane transporter activity
IM776_RS15120	COG2807	transmembrane transport
IM776_RS15125	COG0318	PFAM AMP-dependent synthetase and ligase
IM776_RS15135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM776_RS15140	COG0657	acetylesterase activity
IM776_RS15150	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IM776_RS15160	COG2814	Major facilitator Superfamily
IM776_RS15165	COG1309	transcriptional regulator
IM776_RS15170	COG1414	Transcriptional regulator
IM776_RS15175	COG0183	Belongs to the thiolase family
IM776_RS15180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IM776_RS15195	COG0667	Aldo Keto reductase
IM776_RS15220	COG2159	amidohydrolase
IM776_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
IM776_RS15270	COG0783	Belongs to the Dps family
IM776_RS15290	COG5398	heme oxygenase
IM776_RS15295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IM776_RS15310	COG0776	regulation of translation
IM776_RS15315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IM776_RS15320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IM776_RS15325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IM776_RS15330	COG2094	Belongs to the DNA glycosylase MPG family
IM776_RS15345	COG0701	Predicted permease
IM776_RS15355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM776_RS15360	COG1121	(ABC) transporter
IM776_RS15370	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM776_RS15375	COG0022	dehydrogenase e1 component
IM776_RS15385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IM776_RS15405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM776_RS15440	COG1063	alcohol dehydrogenase
IM776_RS15445	COG1396	sequence-specific DNA binding
IM776_RS15450	COG0740	serine-type endopeptidase activity
IM776_RS15455	COG0740	serine-type endopeptidase activity
IM776_RS15470	COG1121	(ABC) transporter
IM776_RS15475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM776_RS15480	COG0626	cystathionine gamma-synthase activity
IM776_RS15490	COG0534	Mate efflux family protein
IM776_RS15500	COG0596	Alpha beta hydrolase
IM776_RS15505	COG1064	alcohol dehydrogenase
IM776_RS15510	COG1609	Transcriptional regulator
IM776_RS15520	COG1175	transmembrane transport
IM776_RS15540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IM776_RS15555	COG2354	Protein conserved in bacteria
IM776_RS15565	COG0484	heat shock protein binding
IM776_RS15585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IM776_RS15595	COG0588	phosphoglycerate mutase activity
IM776_RS15600	COG1864	DNA RNA non-specific endonuclease
IM776_RS15600	COG3591	Belongs to the peptidase S1B family
IM776_RS15610	COG0305	Participates in initiation and elongation during chromosome replication
IM776_RS15625	COG0359	binds to the 23S rRNA
IM776_RS15630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IM776_RS15640	COG0360	Binds together with S18 to 16S ribosomal RNA
IM776_RS15660	COG2089	acid synthase
IM776_RS15665	COG1083	cytidylyl-transferase
IM776_RS15695	COG0617	tRNA 3'-terminal CCA addition
IM776_RS15705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM776_RS15720	COG2890	protein-(glutamine-N5) methyltransferase activity
IM776_RS15730	COG0492	ferredoxin-NADP+ reductase activity
IM776_RS15735	COG3118	belongs to the thioredoxin family
IM776_RS15745	COG0477	Major facilitator Superfamily
IM776_RS15755	COG1192	Involved in chromosome partitioning
IM776_RS15760	COG0357	Ribosomal RNA small subunit methyltransferase G
IM776_RS15770	COG0706	membrane insertase activity
IM776_RS15775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IM776_RS15785	COG0230	Belongs to the bacterial ribosomal protein bL34 family