locus-tag	class	description
HCR84_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCR84_RS00010	COG0592	DNA-directed DNA polymerase activity
HCR84_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HCR84_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCR84_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HCR84_RS00030	COG0187	DNA topoisomerase II activity
HCR84_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCR84_RS00040	COG3266	domain, Protein
HCR84_RS00075	COG0604	alcohol dehydrogenase
HCR84_RS00125	COG2843	Capsule synthesis protein
HCR84_RS00145	COG2272	Belongs to the type-B carboxylesterase lipase family
HCR84_RS00150	COG0747	negative chemotaxis
HCR84_RS00155	COG2843	Capsule synthesis protein
HCR84_RS00170	COG4172	Belongs to the ABC transporter superfamily
HCR84_RS00175	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS00185	COG0747	negative chemotaxis
HCR84_RS00200	COG2814	Major facilitator Superfamily
HCR84_RS00215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCR84_RS00220	COG2843	Capsule synthesis protein
HCR84_RS00230	COG0765	amino acid transport
HCR84_RS00270	COG0673	inositol 2-dehydrogenase activity
HCR84_RS00275	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS00280	COG1309	transcriptional regulator
HCR84_RS00290	COG0477	Major facilitator Superfamily
HCR84_RS00300	COG2020	methyltransferase activity
HCR84_RS00305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HCR84_RS00330	COG1063	alcohol dehydrogenase
HCR84_RS00335	COG2197	response regulator
HCR84_RS00360	COG2267	carboxylic ester hydrolase activity
HCR84_RS00380	COG0494	nUDIX hydrolase
HCR84_RS00395	COG0457	Tetratricopeptide repeat
HCR84_RS00395	COG0705	Rhomboid family
HCR84_RS00400	COG3548	integral membrane protein
HCR84_RS00420	COG3764	Sortase (surface protein transpeptidase)
HCR84_RS00435	COG0515	serine threonine protein kinase
HCR84_RS00440	COG0515	serine threonine protein kinase
HCR84_RS00445	COG0768	penicillin binding
HCR84_RS00460	COG1716	ATPase activity
HCR84_RS00465	COG1716	ATPase activity
HCR84_RS00490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCR84_RS00525	COG3639	organic phosphonate transmembrane transporter activity
HCR84_RS00530	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HCR84_RS00545	COG1819	glycosyl
HCR84_RS00550	COG1285	pathogenesis
HCR84_RS00595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCR84_RS00600	COG1309	transcriptional regulator
HCR84_RS00615	COG4585	Histidine kinase
HCR84_RS00620	COG1136	(ABC) transporter
HCR84_RS00620	COG0577	efflux transmembrane transporter activity
HCR84_RS00630	COG0793	Belongs to the peptidase S41A family
HCR84_RS00630	COG4946	Tricorn protease homolog
HCR84_RS00665	COG0477	Major facilitator Superfamily
HCR84_RS00685	COG1120	ATPase activity
HCR84_RS00700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCR84_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS00720	COG4941	Belongs to the sigma-70 factor family
HCR84_RS00730	COG2318	DinB family
HCR84_RS00735	COG2409	Drug exporters of the RND superfamily
HCR84_RS00760	COG1846	Transcriptional regulator
HCR84_RS00765	COG2814	Major facilitator Superfamily
HCR84_RS00775	COG0456	acetyltransferase
HCR84_RS00780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCR84_RS00785	COG1917	Cupin 2, conserved barrel domain protein
HCR84_RS00790	COG5285	phytanoyl-CoA dioxygenase
HCR84_RS00830	COG1309	transcriptional regulator
HCR84_RS00840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCR84_RS00850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCR84_RS00865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCR84_RS00870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCR84_RS00875	COG1116	anion transmembrane transporter activity
HCR84_RS00895	COG1960	acyl-CoA dehydrogenase activity
HCR84_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS00915	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS00930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HCR84_RS00935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCR84_RS00940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCR84_RS00945	COG1802	Transcriptional regulator
HCR84_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS00995	COG2207	Transcriptional regulator
HCR84_RS01005	COG0129	dihydroxy-acid dehydratase activity
HCR84_RS01010	COG1733	regulation of RNA biosynthetic process
HCR84_RS01015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCR84_RS01050	COG1131	(ABC) transporter
HCR84_RS01055	COG0789	Transcriptional regulator
HCR84_RS01105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCR84_RS01120	COG2890	protein-(glutamine-N5) methyltransferase activity
HCR84_RS01145	COG0577	efflux transmembrane transporter activity
HCR84_RS01145	COG1136	(ABC) transporter
HCR84_RS01195	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HCR84_RS01200	COG0738	Major facilitator superfamily
HCR84_RS01220	COG2197	response regulator
HCR84_RS01225	COG4585	Histidine kinase
HCR84_RS01235	COG1131	(ABC) transporter
HCR84_RS01260	COG0667	Aldo Keto reductase
HCR84_RS01280	COG3590	peptidase
HCR84_RS01305	COG0747	negative chemotaxis
HCR84_RS01310	COG0601	transmembrane transport
HCR84_RS01320	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS01395	COG1175	transmembrane transport
HCR84_RS01400	COG0395	ABC-type sugar transport system, permease component
HCR84_RS01410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCR84_RS01415	COG2838	Isocitrate dehydrogenase
HCR84_RS01440	COG0423	glycine-tRNA ligase activity
HCR84_RS01450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCR84_RS01455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCR84_RS01480	COG3253	May function as heme-dependent peroxidase
HCR84_RS01485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCR84_RS01490	COG0181	hydroxymethylbilane synthase activity
HCR84_RS01510	COG0113	porphobilinogen synthase activity
HCR84_RS01515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCR84_RS01520	COG3340	Belongs to the peptidase S51 family
HCR84_RS01530	COG0604	alcohol dehydrogenase
HCR84_RS01545	COG1131	(ABC) transporter
HCR84_RS01555	COG1054	Belongs to the UPF0176 family
HCR84_RS01565	COG1309	transcriptional regulator
HCR84_RS01570	COG1881	PFAM PEBP family protein
HCR84_RS01575	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HCR84_RS01580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCR84_RS01585	COG1414	Transcriptional regulator
HCR84_RS01615	COG0706	membrane insertase activity
HCR84_RS01630	COG1131	(ABC) transporter
HCR84_RS01635	COG1309	transcriptional regulator
HCR84_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS01655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCR84_RS01660	COG1024	Enoyl-CoA hydratase
HCR84_RS01670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCR84_RS01680	COG0039	L-malate dehydrogenase activity
HCR84_RS01690	COG1846	Transcriptional regulator
HCR84_RS01710	COG2079	MmgE PrpD family protein
HCR84_RS01715	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCR84_RS01730	COG1309	transcriptional regulator
HCR84_RS01785	COG1733	regulation of RNA biosynthetic process
HCR84_RS01815	COG1940	carbohydrate kinase activity
HCR84_RS01825	COG1846	Transcriptional regulator
HCR84_RS01825	COG1940	carbohydrate kinase activity
HCR84_RS01835	COG1175	transmembrane transport
HCR84_RS01840	COG0395	ABC-type sugar transport system, permease component
HCR84_RS01860	COG0601	transmembrane transport
HCR84_RS01870	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS01890	COG0583	DNA-binding transcription factor activity
HCR84_RS01910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCR84_RS01915	COG1653	transport
HCR84_RS01920	COG1175	transmembrane transport
HCR84_RS01925	COG0395	ABC-type sugar transport system, permease component
HCR84_RS01935	COG0673	inositol 2-dehydrogenase activity
HCR84_RS01945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCR84_RS01965	COG0569	domain protein
HCR84_RS01970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCR84_RS01990	COG1476	TRANSCRIPTIONal
HCR84_RS02025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCR84_RS02030	COG0406	alpha-ribazole phosphatase activity
HCR84_RS02040	COG0785	Cytochrome C biogenesis protein
HCR84_RS02055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCR84_RS02065	COG4948	Mandelate Racemase Muconate Lactonizing
HCR84_RS02080	COG1575	Belongs to the MenA family. Type 1 subfamily
HCR84_RS02100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCR84_RS02110	COG2226	methyltransferase
HCR84_RS02115	COG0142	geranyltranstransferase activity
HCR84_RS02125	COG1064	alcohol dehydrogenase
HCR84_RS02130	COG1309	transcriptional regulator
HCR84_RS02145	COG2814	Major facilitator Superfamily
HCR84_RS02175	COG1666	GTP binding
HCR84_RS02185	COG0589	response to stress
HCR84_RS02205	COG3119	arylsulfatase activity
HCR84_RS02210	COG4166	transmembrane transport
HCR84_RS02215	COG0601	transmembrane transport
HCR84_RS02225	COG4172	Belongs to the ABC transporter superfamily
HCR84_RS02235	COG2723	6-phospho-beta-galactosidase activity
HCR84_RS02250	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS02260	COG0477	Major facilitator Superfamily
HCR84_RS02265	COG1316	TRANSCRIPTIONal
HCR84_RS02300	COG3181	Tripartite tricarboxylate transporter family receptor
HCR84_RS02305	COG3290	protein histidine kinase activity
HCR84_RS02310	COG4565	transcriptional regulatory protein
HCR84_RS02315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCR84_RS02320	COG0318	PFAM AMP-dependent synthetase and ligase
HCR84_RS02325	COG1725	Transcriptional regulator
HCR84_RS02330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCR84_RS02360	COG1834	amidinotransferase
HCR84_RS02375	COG0463	Glycosyl transferase, family 2
HCR84_RS02400	COG2205	protein histidine kinase activity
HCR84_RS02420	COG2186	Transcriptional regulator
HCR84_RS02430	COG0564	pseudouridine synthase activity
HCR84_RS02440	COG4221	oxidoreductase activity
HCR84_RS02450	COG2186	Transcriptional regulator
HCR84_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS02470	COG0395	ABC-type sugar transport system, permease component
HCR84_RS02475	COG1063	alcohol dehydrogenase
HCR84_RS02505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCR84_RS02520	COG1070	Carbohydrate kinase
HCR84_RS02525	COG3347	Dehydrogenase
HCR84_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS02540	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS02545	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS02550	COG1129	ABC transporter
HCR84_RS02555	COG1609	Transcriptional regulator
HCR84_RS02575	COG3408	Glycogen debranching enzyme
HCR84_RS02585	COG1175	transmembrane transport
HCR84_RS02595	COG3250	beta-galactosidase activity
HCR84_RS02620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCR84_RS02625	COG4106	trans-aconitate 2-methyltransferase activity
HCR84_RS02630	COG3424	synthase
HCR84_RS02635	COG2814	Major facilitator Superfamily
HCR84_RS02650	COG2267	carboxylic ester hydrolase activity
HCR84_RS02670	COG0588	phosphoglycerate mutase activity
HCR84_RS02675	COG0095	Lipoate-protein ligase
HCR84_RS02680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HCR84_RS02685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCR84_RS02690	COG0822	iron-sulfur transferase activity
HCR84_RS02710	COG0395	ABC-type sugar transport system, permease component
HCR84_RS02735	COG0077	Prephenate dehydratase
HCR84_RS02750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCR84_RS02755	COG1597	lipid kinase activity
HCR84_RS02760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCR84_RS02765	COG0561	phosphatase activity
HCR84_RS02775	COG1316	TRANSCRIPTIONal
HCR84_RS02795	COG3237	CsbD-like
HCR84_RS02810	COG2124	cytochrome p450
HCR84_RS02820	COG1414	Transcriptional regulator
HCR84_RS02825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCR84_RS02830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCR84_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCR84_RS02845	COG0765	amino acid transport
HCR84_RS02850	COG0765	amino acid transport
HCR84_RS02855	COG1126	abc transporter atp-binding protein
HCR84_RS02880	COG0667	Aldo Keto reductase
HCR84_RS02915	COG1175	transmembrane transport
HCR84_RS02920	COG0395	ABC-type sugar transport system, permease component
HCR84_RS02930	COG2017	converts alpha-aldose to the beta-anomer
HCR84_RS02945	COG1295	ribonuclease BN
HCR84_RS02950	COG1846	Transcriptional regulator
HCR84_RS02965	COG4585	Histidine kinase
HCR84_RS02970	COG2197	response regulator
HCR84_RS02980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCR84_RS02990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCR84_RS02995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HCR84_RS03000	COG1609	Transcriptional regulator
HCR84_RS03015	COG0693	protein deglycase activity
HCR84_RS03030	COG0739	heme binding
HCR84_RS03035	COG0366	Alpha amylase catalytic
HCR84_RS03045	COG1175	transmembrane transport
HCR84_RS03050	COG3833	ABC-type maltose transport systems, permease component
HCR84_RS03055	COG0366	Alpha amylase catalytic
HCR84_RS03085	COG0583	DNA-binding transcription factor activity
HCR84_RS03090	COG2855	membrane
HCR84_RS03130	COG0730	response to heat
HCR84_RS03145	COG2030	dehydratase
HCR84_RS03155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCR84_RS03175	COG0436	Aminotransferase
HCR84_RS03185	COG1120	ATPase activity
HCR84_RS03200	COG2826	transposase and inactivated derivatives, IS30 family
HCR84_RS03215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCR84_RS03230	COG2826	transposase and inactivated derivatives, IS30 family
HCR84_RS03245	COG1609	Transcriptional regulator
HCR84_RS03250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCR84_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS03275	COG0250	Participates in transcription elongation, termination and antitermination
HCR84_RS03280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCR84_RS03285	COG0081	regulation of translation
HCR84_RS03295	COG0604	alcohol dehydrogenase
HCR84_RS03295	COG3321	synthase
HCR84_RS03315	COG0673	inositol 2-dehydrogenase activity
HCR84_RS03330	COG0673	inositol 2-dehydrogenase activity
HCR84_RS03335	COG0673	inositol 2-dehydrogenase activity
HCR84_RS03360	COG0745	RESPONSE REGULATOR receiver
HCR84_RS03365	COG2205	protein histidine kinase activity
HCR84_RS03370	COG2233	PERMEase
HCR84_RS03375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCR84_RS03380	COG0590	tRNA wobble adenosine to inosine editing
HCR84_RS03385	COG2252	PERMEase
HCR84_RS03395	COG1414	Transcriptional regulator
HCR84_RS03420	COG0402	S-adenosylhomocysteine deaminase activity
HCR84_RS03430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCR84_RS03440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCR84_RS03445	COG0222	ribosome binding
HCR84_RS03455	COG2814	Major facilitator Superfamily
HCR84_RS03460	COG1609	Transcriptional regulator
HCR84_RS03465	COG1653	transport
HCR84_RS03470	COG1175	transmembrane transport
HCR84_RS03475	COG0395	ABC-type sugar transport system, permease component
HCR84_RS03480	COG1132	(ABC) transporter
HCR84_RS03515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCR84_RS03525	COG1116	anion transmembrane transporter activity
HCR84_RS03530	COG1609	Transcriptional regulator
HCR84_RS03535	COG1129	ABC transporter
HCR84_RS03540	COG1879	ABC-type sugar transport system periplasmic component
HCR84_RS03550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS03560	COG1609	Transcriptional regulator
HCR84_RS03570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCR84_RS03590	COG0673	inositol 2-dehydrogenase activity
HCR84_RS03600	COG1609	Transcriptional regulator
HCR84_RS03610	COG1737	Transcriptional regulator
HCR84_RS03615	COG4821	SIS domain
HCR84_RS03620	COG1653	transport
HCR84_RS03625	COG1175	transmembrane transport
HCR84_RS03630	COG0395	ABC-type sugar transport system, permease component
HCR84_RS03635	COG0395	ABC-type sugar transport system, permease component
HCR84_RS03640	COG1175	transmembrane transport
HCR84_RS03650	COG1609	Transcriptional regulator
HCR84_RS03655	COG1070	Carbohydrate kinase
HCR84_RS03660	COG2115	Belongs to the xylose isomerase family
HCR84_RS03670	COG4213	ABC transporter substrate-binding protein
HCR84_RS03675	COG1129	ABC transporter
HCR84_RS03680	COG4214	carbohydrate transport
HCR84_RS03685	COG1940	carbohydrate kinase activity
HCR84_RS03710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HCR84_RS03715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCR84_RS03730	COG0085	RNA polymerase activity
HCR84_RS03735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCR84_RS03780	COG0515	serine threonine protein kinase
HCR84_RS03780	COG2815	serine threonine protein kinase
HCR84_RS03795	COG0714	Associated with various cellular activities
HCR84_RS03805	COG1305	Transglutaminase-like
HCR84_RS03850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCR84_RS03855	COG0049	tRNA binding
HCR84_RS03860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCR84_RS03865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCR84_RS03875	COG0051	transcription antitermination factor activity, RNA binding
HCR84_RS03880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCR84_RS03885	COG0088	Forms part of the polypeptide exit tunnel
HCR84_RS03890	COG0089	rRNA binding
HCR84_RS03895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCR84_RS03900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCR84_RS03905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCR84_RS03910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCR84_RS03915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCR84_RS03920	COG0255	Belongs to the universal ribosomal protein uL29 family
HCR84_RS03925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCR84_RS03930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCR84_RS03935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCR84_RS03940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCR84_RS03945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCR84_RS03950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCR84_RS03955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCR84_RS03960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCR84_RS03965	COG1841	ribosomal large subunit assembly
HCR84_RS03970	COG0200	Binds to the 23S rRNA
HCR84_RS03980	COG0563	adenylate kinase activity
HCR84_RS03985	COG0024	Methionine aminopeptidase
HCR84_RS03995	COG3711	transcriptional antiterminator
HCR84_RS03995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCR84_RS04010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCR84_RS04025	COG0246	Mannitol dehydrogenase
HCR84_RS04030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCR84_RS04040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCR84_RS04045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCR84_RS04050	COG0202	RNA polymerase activity
HCR84_RS04055	COG0203	ribosomal protein L17
HCR84_RS04065	COG1506	peptidase
HCR84_RS04065	COG0823	Involved in the tonB-independent uptake of proteins
HCR84_RS04075	COG2755	lipolytic protein G-D-S-L family
HCR84_RS04075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCR84_RS04085	COG3848	Pyruvate phosphate dikinase
HCR84_RS04085	COG0574	Belongs to the PEP-utilizing enzyme family
HCR84_RS04090	COG0101	tRNA pseudouridine synthase activity
HCR84_RS04105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCR84_RS04110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCR84_RS04115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCR84_RS04120	COG1115	amino acid carrier protein
HCR84_RS04130	COG1072	(Pantothenic acid kinase))
HCR84_RS04135	COG2066	Belongs to the glutaminase family
HCR84_RS04145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCR84_RS04150	COG0736	holo-[acyl-carrier-protein] synthase activity
HCR84_RS04155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCR84_RS04160	COG0802	atpase or kinase
HCR84_RS04175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCR84_RS04195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCR84_RS04225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCR84_RS04230	COG0395	ABC-type sugar transport system, permease component
HCR84_RS04255	COG0516	GMP reductase activity
HCR84_RS04260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCR84_RS04265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCR84_RS04270	COG0318	PFAM AMP-dependent synthetase and ligase
HCR84_RS04275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCR84_RS04290	COG0519	Catalyzes the synthesis of GMP from XMP
HCR84_RS04290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCR84_RS04305	COG1643	Atp-dependent helicase
HCR84_RS04310	COG1487	ribonuclease activity
HCR84_RS04360	COG4115	mRNA cleavage
HCR84_RS04380	COG2076	Multidrug Resistance protein
HCR84_RS04395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCR84_RS04430	COG0045	succinate-CoA ligase (ADP-forming) activity
HCR84_RS04450	COG0138	bifunctional purine biosynthesis protein purh
HCR84_RS04455	COG1834	amidinotransferase
HCR84_RS04465	COG1132	(ABC) transporter
HCR84_RS04495	COG1472	Belongs to the glycosyl hydrolase 3 family
HCR84_RS04500	COG0363	glucosamine-6-phosphate deaminase activity
HCR84_RS04505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCR84_RS04510	COG0277	FAD linked oxidase domain protein
HCR84_RS04525	COG0765	amino acid transport
HCR84_RS04540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCR84_RS04620	COG2814	Major facilitator Superfamily
HCR84_RS04630	COG0733	neurotransmitter:sodium symporter activity
HCR84_RS04635	COG2814	Major facilitator Superfamily
HCR84_RS04645	COG2111	Na H antiporter
HCR84_RS04645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCR84_RS04650	COG1006	Multisubunit Na H antiporter MnhC subunit
HCR84_RS04655	COG0651	ATP synthesis coupled electron transport
HCR84_RS04670	COG1320	monovalent cation:proton antiporter activity
HCR84_RS04675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCR84_RS04680	COG1349	DNA-binding transcription factor activity
HCR84_RS04690	COG1105	Belongs to the carbohydrate kinase PfkB family
HCR84_RS04720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCR84_RS04725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCR84_RS04735	COG2089	acid synthase
HCR84_RS04745	COG0583	DNA-binding transcription factor activity
HCR84_RS04755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCR84_RS04760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCR84_RS04770	COG1349	DNA-binding transcription factor activity
HCR84_RS04825	COG0477	Major facilitator Superfamily
HCR84_RS04835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCR84_RS04840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCR84_RS04840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCR84_RS04865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCR84_RS04870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCR84_RS04875	COG1011	Hydrolase
HCR84_RS04880	COG0180	Tryptophanyl-tRNA synthetase
HCR84_RS04920	COG2009	succinate dehydrogenase
HCR84_RS04940	COG0488	(ABC) transporter
HCR84_RS04950	COG0477	Major facilitator Superfamily
HCR84_RS04965	COG1744	ABC transporter substrate-binding protein PnrA-like
HCR84_RS04970	COG1744	ABC transporter substrate-binding protein PnrA-like
HCR84_RS04975	COG3845	ABC transporter
HCR84_RS04980	COG4603	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS04985	COG1079	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS05010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCR84_RS05015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCR84_RS05025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCR84_RS05045	COG4770	biotin carboxylase activity
HCR84_RS05050	COG0424	maF-like protein
HCR84_RS05055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCR84_RS05085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCR84_RS05125	COG0559	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS05145	COG1802	Transcriptional regulator
HCR84_RS05150	COG1402	creatininase
HCR84_RS05165	COG0277	FAD linked oxidase domain protein
HCR84_RS05175	COG2197	response regulator
HCR84_RS05180	COG4585	Histidine kinase
HCR84_RS05215	COG0302	gtp cyclohydrolase
HCR84_RS05230	COG0586	Pfam SNARE associated Golgi protein
HCR84_RS05240	COG1316	TRANSCRIPTIONal
HCR84_RS05255	COG2247	cell wall binding repeat
HCR84_RS05255	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCR84_RS05305	COG1132	(ABC) transporter
HCR84_RS05320	COG0438	transferase activity, transferring glycosyl groups
HCR84_RS05335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCR84_RS05350	COG3594	Acyltransferase
HCR84_RS05355	COG1088	dTDP-glucose 4,6-dehydratase activity
HCR84_RS05385	COG1215	transferase activity, transferring glycosyl groups
HCR84_RS05390	COG1216	Glycosyl transferase, family 2
HCR84_RS05395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCR84_RS05405	COG1216	Glycosyl transferase, family 2
HCR84_RS05435	COG1960	acyl-CoA dehydrogenase activity
HCR84_RS05440	COG1482	cell wall glycoprotein biosynthetic process
HCR84_RS05450	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCR84_RS05480	COG1309	transcriptional regulator
HCR84_RS05510	COG1331	Highly conserved protein containing a thioredoxin domain
HCR84_RS05515	COG1760	l-serine dehydratase
HCR84_RS05520	COG3001	Fructosamine kinase
HCR84_RS05535	COG0471	metal ion transport
HCR84_RS05560	COG0025	NhaP-type Na H and K H
HCR84_RS05570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCR84_RS05580	COG2409	Drug exporters of the RND superfamily
HCR84_RS05585	COG2365	Tyrosine phosphatase family
HCR84_RS05600	COG1832	CoA-binding protein
HCR84_RS05620	COG2807	transmembrane transport
HCR84_RS05630	COG2855	membrane
HCR84_RS05655	COG0667	Aldo Keto reductase
HCR84_RS05660	COG0028	Belongs to the TPP enzyme family
HCR84_RS05665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCR84_RS05670	COG0084	hydrolase, TatD family'
HCR84_RS05675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCR84_RS05685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCR84_RS05690	COG0488	(ABC) transporter
HCR84_RS05695	COG1131	(ABC) transporter
HCR84_RS05705	COG4585	Histidine kinase
HCR84_RS05710	COG2197	response regulator
HCR84_RS05735	COG1278	Cold shock
HCR84_RS05740	COG1464	Belongs to the NlpA lipoprotein family
HCR84_RS05745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCR84_RS05750	COG2011	ABC-type metal ion transport system permease component
HCR84_RS05755	COG1846	Transcriptional regulator
HCR84_RS05765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCR84_RS05770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCR84_RS05785	COG0246	Mannitol dehydrogenase
HCR84_RS05790	COG1904	glucuronate isomerase
HCR84_RS05810	COG0673	inositol 2-dehydrogenase activity
HCR84_RS05835	COG1609	Transcriptional regulator
HCR84_RS05855	COG4948	Mandelate Racemase Muconate Lactonizing
HCR84_RS05860	COG3265	gluconokinase activity
HCR84_RS05870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCR84_RS05875	COG0193	aminoacyl-tRNA hydrolase activity
HCR84_RS05895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCR84_RS05900	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS05905	COG3956	TIGRFAM MazG family protein
HCR84_RS05910	COG0124	histidyl-tRNA synthetase
HCR84_RS05915	COG0148	phosphopyruvate hydratase activity
HCR84_RS05930	COG1404	Belongs to the peptidase S8 family
HCR84_RS05960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCR84_RS05960	COG0351	phosphomethylpyrimidine kinase
HCR84_RS05960	COG0352	thiamine-phosphate diphosphorylase activity
HCR84_RS05970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCR84_RS05990	COG1704	LemA family
HCR84_RS05995	COG0501	Belongs to the peptidase M48B family
HCR84_RS06005	COG3214	Protein conserved in bacteria
HCR84_RS06015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCR84_RS06020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCR84_RS06030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCR84_RS06045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCR84_RS06055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCR84_RS06070	COG0114	fumarate hydratase activity
HCR84_RS06075	COG0288	reversible hydration of carbon dioxide
HCR84_RS06085	COG1722	exodeoxyribonuclease VII activity
HCR84_RS06090	COG1570	exodeoxyribonuclease VII activity
HCR84_RS06095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCR84_RS06105	COG0191	fructose-bisphosphate aldolase activity
HCR84_RS06110	COG1494	fructose-1,6-bisphosphatase
HCR84_RS06120	COG1322	Protein conserved in bacteria
HCR84_RS06130	COG0012	GTP binding
HCR84_RS06145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCR84_RS06160	COG0697	spore germination
HCR84_RS06270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCR84_RS06270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCR84_RS06280	COG3173	Aminoglycoside phosphotransferase
HCR84_RS06285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCR84_RS06295	COG2814	Major facilitator Superfamily
HCR84_RS06320	COG4989	oxidoreductase activity
HCR84_RS06325	COG0352	thiamine-phosphate diphosphorylase activity
HCR84_RS06340	COG2022	thiamine diphosphate biosynthetic process
HCR84_RS06390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCR84_RS06405	COG1104	cysteine desulfurase activity
HCR84_RS06415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCR84_RS06420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCR84_RS06440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCR84_RS06445	COG0509	glycine decarboxylation via glycine cleavage system
HCR84_RS06450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCR84_RS06450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCR84_RS06455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCR84_RS06475	COG4166	transmembrane transport
HCR84_RS06480	COG0601	transmembrane transport
HCR84_RS06485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCR84_RS06520	COG1217	gtp-binding protein TYPA
HCR84_RS06565	COG2171	N-acyltransferase activity
HCR84_RS06570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCR84_RS06585	COG4122	O-methyltransferase activity
HCR84_RS06590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCR84_RS06595	COG2814	Major facilitator Superfamily
HCR84_RS06600	COG2226	methyltransferase
HCR84_RS06615	COG2239	Acts as a magnesium transporter
HCR84_RS06625	COG0006	proline dipeptidase activity
HCR84_RS06635	COG0613	PHP domain protein
HCR84_RS06640	COG0513	Belongs to the DEAD box helicase family
HCR84_RS06690	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCR84_RS06695	COG1615	UPF0182 protein
HCR84_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS06710	COG1309	transcriptional regulator
HCR84_RS06720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCR84_RS06730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCR84_RS06770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCR84_RS06775	COG1131	(ABC) transporter
HCR84_RS06795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCR84_RS06800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCR84_RS06805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCR84_RS06815	COG0586	Pfam SNARE associated Golgi protein
HCR84_RS06865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCR84_RS06870	COG2884	Cell division ATP-binding protein ftsE
HCR84_RS06875	COG2177	Part of the ABC transporter FtsEX involved in
HCR84_RS06880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCR84_RS06890	COG0483	inositol monophosphate 1-phosphatase activity
HCR84_RS06900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCR84_RS06915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCR84_RS06930	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HCR84_RS06940	COG0129	dihydroxy-acid dehydratase activity
HCR84_RS06945	COG0028	Belongs to the TPP enzyme family
HCR84_RS06950	COG0440	acetolactate synthase activity
HCR84_RS06955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCR84_RS06985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCR84_RS06990	COG0473	3-isopropylmalate dehydrogenase activity
HCR84_RS06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCR84_RS07000	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCR84_RS07030	COG3425	synthase
HCR84_RS07035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCR84_RS07040	COG0492	ferredoxin-NADP+ reductase activity
HCR84_RS07090	COG1597	lipid kinase activity
HCR84_RS07105	COG0601	transmembrane transport
HCR84_RS07125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCR84_RS07130	COG0066	3-isopropylmalate dehydratase activity
HCR84_RS07135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCR84_RS07145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCR84_RS07150	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCR84_RS07175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCR84_RS07180	COG0714	Associated with various cellular activities
HCR84_RS07200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCR84_RS07205	COG0571	ribonuclease III activity
HCR84_RS07210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCR84_RS07215	COG1309	transcriptional regulator
HCR84_RS07220	COG1131	(ABC) transporter
HCR84_RS07245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCR84_RS07250	COG0321	lipoyl(octanoyl) transferase activity
HCR84_RS07260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCR84_RS07265	COG0228	four-way junction DNA binding
HCR84_RS07270	COG1837	Belongs to the UPF0109 family
HCR84_RS07275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCR84_RS07280	COG0336	Belongs to the RNA methyltransferase TrmD family
HCR84_RS07295	COG0335	large ribosomal subunit rRNA binding
HCR84_RS07300	COG0681	Belongs to the peptidase S26 family
HCR84_RS07305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCR84_RS07315	COG0792	nuclease activity
HCR84_RS07330	COG4974	Belongs to the 'phage' integrase family
HCR84_RS07340	COG0052	Belongs to the universal ribosomal protein uS2 family
HCR84_RS07345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCR84_RS07350	COG0528	UMP kinase activity
HCR84_RS07355	COG0233	cytoplasmic translational termination
HCR84_RS07395	COG3118	belongs to the thioredoxin family
HCR84_RS07410	COG0482	sulfurtransferase activity
HCR84_RS07420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCR84_RS07425	COG0318	PFAM AMP-dependent synthetase and ligase
HCR84_RS07430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCR84_RS07435	COG0154	amidase activity
HCR84_RS07440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCR84_RS07450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCR84_RS07460	COG4721	ABC-type cobalt transport system, permease component
HCR84_RS07465	COG4172	Belongs to the ABC transporter superfamily
HCR84_RS07475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCR84_RS07475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCR84_RS07490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HCR84_RS07515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCR84_RS07520	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HCR84_RS07540	COG1716	ATPase activity
HCR84_RS07555	COG1192	Involved in chromosome partitioning
HCR84_RS07565	COG0455	bacterial-type flagellum organization
HCR84_RS07580	COG1940	carbohydrate kinase activity
HCR84_RS07585	COG0204	Acyl-transferase
HCR84_RS07590	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HCR84_RS07595	COG2815	serine threonine protein kinase
HCR84_RS07595	COG0515	serine threonine protein kinase
HCR84_RS07600	COG1388	LysM domain
HCR84_RS07600	COG3942	CHAP domain
HCR84_RS07610	COG0142	geranyltranstransferase activity
HCR84_RS07620	COG2001	Belongs to the MraZ family
HCR84_RS07625	COG0275	rRNA processing
HCR84_RS07635	COG0768	penicillin binding
HCR84_RS07645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCR84_RS07650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCR84_RS07660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCR84_RS07665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCR84_RS07675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCR84_RS07680	COG1799	cell septum assembly
HCR84_RS07690	COG3599	regulation of cell shape
HCR84_RS07695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCR84_RS07705	COG0587	DNA-directed DNA polymerase activity
HCR84_RS07715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCR84_RS07720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCR84_RS07725	COG0167	dihydroorotate dehydrogenase activity
HCR84_RS07745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCR84_RS07750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCR84_RS07760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCR84_RS07765	COG0723	plastoquinol--plastocyanin reductase activity
HCR84_RS07770	COG2010	Cytochrome c
HCR84_RS07775	COG1845	cytochrome c oxidase, subunit III
HCR84_RS07780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCR84_RS07785	COG2376	Dihydroxyacetone kinase
HCR84_RS07795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCR84_RS07795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCR84_RS07795	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HCR84_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS07855	COG0584	glycerophosphoryl diester phosphodiesterase
HCR84_RS07875	COG0805	protein transport
HCR84_RS07880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCR84_RS07905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCR84_RS07915	COG0215	cysteine-tRNA ligase activity
HCR84_RS07920	COG1968	undecaprenyl-diphosphatase activity
HCR84_RS07925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCR84_RS07940	COG2197	response regulator
HCR84_RS07945	COG4585	Histidine kinase
HCR84_RS07955	COG2755	lipolytic protein G-D-S-L family
HCR84_RS07970	COG0406	alpha-ribazole phosphatase activity
HCR84_RS07985	COG0366	Alpha amylase catalytic
HCR84_RS07995	COG0254	rRNA binding
HCR84_RS08000	COG1119	ATPase activity
HCR84_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS08025	COG0488	(ABC) transporter
HCR84_RS08030	COG2151	metal-sulfur cluster biosynthetic enzyme
HCR84_RS08035	COG0396	ATPase activity
HCR84_RS08055	COG1612	heme a metabolic process
HCR84_RS08060	COG0109	protoheme IX farnesyltransferase activity
HCR84_RS08070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCR84_RS08075	COG0166	Belongs to the GPI family
HCR84_RS08090	COG0363	glucosamine-6-phosphate deaminase activity
HCR84_RS08100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCR84_RS08105	COG0149	triose-phosphate isomerase activity
HCR84_RS08110	COG0126	phosphoglycerate kinase activity
HCR84_RS08115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCR84_RS08120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCR84_RS08125	COG1481	regulation of sporulation
HCR84_RS08130	COG1660	Displays ATPase and GTPase activities
HCR84_RS08135	COG0322	excinuclease ABC activity
HCR84_RS08145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HCR84_RS08160	COG0714	Associated with various cellular activities
HCR84_RS08175	COG0556	nucleotide-excision repair
HCR84_RS08180	COG0237	dephospho-CoA kinase activity
HCR84_RS08185	COG1309	transcriptional regulator
HCR84_RS08190	COG0539	negative regulation of cytoplasmic translation
HCR84_RS08205	COG2050	protein possibly involved in aromatic compounds catabolism
HCR84_RS08215	COG0765	amino acid transport
HCR84_RS08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCR84_RS08235	COG0469	pyruvate kinase activity
HCR84_RS08245	COG0067	glutamate synthase
HCR84_RS08245	COG0069	glutamate synthase activity
HCR84_RS08245	COG0070	glutamate synthase
HCR84_RS08250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCR84_RS08255	COG0159	tryptophan synthase activity
HCR84_RS08260	COG0133	tryptophan synthase activity
HCR84_RS08265	COG0134	indole-3-glycerol-phosphate synthase activity
HCR84_RS08285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCR84_RS08290	COG0107	imidazoleglycerol-phosphate synthase activity
HCR84_RS08295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCR84_RS08300	COG0140	phosphoribosyl-ATP diphosphatase activity
HCR84_RS08305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCR84_RS08315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCR84_RS08325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCR84_RS08330	COG1758	RNA polymerase activity
HCR84_RS08335	COG0194	GDP metabolic process
HCR84_RS08345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCR84_RS08350	COG0505	Belongs to the CarA family
HCR84_RS08360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCR84_RS08365	COG0540	Belongs to the ATCase OTCase family
HCR84_RS08370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCR84_RS08375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCR84_RS08380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCR84_RS08385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCR84_RS08390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCR84_RS08400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCR84_RS08405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCR84_RS08410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCR84_RS08415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCR84_RS08420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCR84_RS08430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCR84_RS08445	COG1196	nuclear chromosome segregation
HCR84_RS08455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCR84_RS08460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCR84_RS08465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCR84_RS08475	COG2255	four-way junction helicase activity
HCR84_RS08480	COG0632	four-way junction helicase activity
HCR84_RS08485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCR84_RS08490	COG0217	transcriptional regulatory protein
HCR84_RS08495	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HCR84_RS08505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCR84_RS08535	COG1309	transcriptional regulator
HCR84_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS08560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCR84_RS08585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HCR84_RS08590	COG0183	Belongs to the thiolase family
HCR84_RS08595	COG1024	Enoyl-CoA hydratase
HCR84_RS08595	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCR84_RS08600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCR84_RS08605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCR84_RS08620	COG0756	dUTP diphosphatase activity
HCR84_RS08645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCR84_RS08650	COG0187	DNA topoisomerase II activity
HCR84_RS08660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCR84_RS08665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCR84_RS08680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCR84_RS08695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCR84_RS08700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCR84_RS08705	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCR84_RS08725	COG0174	glutamine synthetase
HCR84_RS08730	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HCR84_RS08765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCR84_RS08785	COG0477	Major facilitator Superfamily
HCR84_RS08810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCR84_RS08815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCR84_RS08855	COG0297	glycogen (starch) synthase activity
HCR84_RS08865	COG0242	peptide deformylase activity
HCR84_RS08875	COG4608	Belongs to the ABC transporter superfamily
HCR84_RS08880	COG0358	DNA primase activity
HCR84_RS08900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCR84_RS08905	COG1381	Involved in DNA repair and RecF pathway recombination
HCR84_RS08910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCR84_RS08915	COG2197	response regulator
HCR84_RS08935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCR84_RS08945	COG0537	adenosine 5'-monophosphoramidase activity
HCR84_RS08955	COG0484	heat shock protein binding
HCR84_RS08960	COG1420	regulation of RNA biosynthetic process
HCR84_RS08975	COG4762	Protein conserved in bacteria
HCR84_RS08980	COG0481	GTPase activity
HCR84_RS08985	COG0268	Binds directly to 16S ribosomal RNA
HCR84_RS09010	COG1596	polysaccharide export
HCR84_RS09010	COG1555	photosystem II stabilization
HCR84_RS09015	COG0495	leucyl-tRNA aminoacylation
HCR84_RS09020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCR84_RS09025	COG4988	ABC transporter
HCR84_RS09030	COG1294	oxidase, subunit
HCR84_RS09035	COG1271	oxidase subunit
HCR84_RS09065	COG4129	membrane
HCR84_RS09070	COG3012	SEC-C Motif Domain Protein
HCR84_RS09075	COG0512	Glutamine amidotransferase of anthranilate synthase
HCR84_RS09075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCR84_RS09085	COG0583	DNA-binding transcription factor activity
HCR84_RS09095	COG0799	negative regulation of ribosome biogenesis
HCR84_RS09105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCR84_RS09115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCR84_RS09120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCR84_RS09125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCR84_RS09130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCR84_RS09135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCR84_RS09145	COG1530	ribonuclease E activity
HCR84_RS09155	COG0105	UTP biosynthetic process
HCR84_RS09165	COG0285	dihydrofolate synthase activity
HCR84_RS09170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCR84_RS09180	COG2755	lipolytic protein G-D-S-L family
HCR84_RS09180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCR84_RS09185	COG0525	valine-tRNA ligase activity
HCR84_RS09195	COG2226	methyltransferase
HCR84_RS09200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCR84_RS09205	COG0740	serine-type endopeptidase activity
HCR84_RS09210	COG0740	serine-type endopeptidase activity
HCR84_RS09215	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCR84_RS09245	COG0783	Belongs to the Dps family
HCR84_RS09250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCR84_RS09260	COG0698	ribose 5-phosphate isomerase
HCR84_RS09265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCR84_RS09275	COG0668	transmembrane transport
HCR84_RS09295	COG1946	Acyl-CoA thioesterase
HCR84_RS09315	COG0629	single-stranded DNA binding
HCR84_RS09320	COG0667	Aldo Keto reductase
HCR84_RS09335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCR84_RS09340	COG0587	DNA-directed DNA polymerase activity
HCR84_RS09345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCR84_RS09355	COG2135	peptidase activity
HCR84_RS09360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HCR84_RS09370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCR84_RS09375	COG0022	dehydrogenase e1 component
HCR84_RS09380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCR84_RS09385	COG1309	transcriptional regulator
HCR84_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS09415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCR84_RS09475	COG1733	regulation of RNA biosynthetic process
HCR84_RS09495	COG1131	(ABC) transporter
HCR84_RS09550	COG2826	transposase and inactivated derivatives, IS30 family
HCR84_RS09590	COG1160	GTP binding
HCR84_RS09595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCR84_RS09610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HCR84_RS09615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HCR84_RS09625	COG4974	Belongs to the 'phage' integrase family
HCR84_RS09630	COG0494	nUDIX hydrolase
HCR84_RS09635	COG0504	CTP synthase activity
HCR84_RS09640	COG0497	DNA recombination
HCR84_RS09645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCR84_RS09660	COG0647	UMP catabolic process
HCR84_RS09690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCR84_RS09705	COG2094	Belongs to the DNA glycosylase MPG family
HCR84_RS09710	COG0165	Argininosuccinate lyase
HCR84_RS09715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCR84_RS09725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCR84_RS09730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCR84_RS09735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCR84_RS09745	COG0072	phenylalanine-tRNA ligase activity
HCR84_RS09745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCR84_RS09750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCR84_RS09755	COG0765	amino acid transport
HCR84_RS09760	COG0765	amino acid transport
HCR84_RS09765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCR84_RS09770	COG1126	abc transporter atp-binding protein
HCR84_RS09775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCR84_RS09780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCR84_RS09785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCR84_RS09790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCR84_RS09805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCR84_RS09810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCR84_RS09815	COG0131	Imidazoleglycerol-phosphate dehydratase
HCR84_RS09820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCR84_RS09825	COG1388	LysM domain
HCR84_RS09830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCR84_RS09835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCR84_RS09840	COG2813	Specifically methylates the guanine in position
HCR84_RS09845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCR84_RS09850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCR84_RS09855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCR84_RS09860	COG2137	regulation of response to DNA damage stimulus
HCR84_RS09865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCR84_RS09880	COG1058	Belongs to the CinA family
HCR84_RS09880	COG1546	Belongs to the CinA family
HCR84_RS09890	COG1674	ftsk spoiiie
HCR84_RS09895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCR84_RS09900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCR84_RS09905	COG0300	oxidoreductase activity
HCR84_RS09910	COG1764	response to oxidative stress
HCR84_RS09920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCR84_RS09935	COG0612	Peptidase, M16
HCR84_RS09940	COG0667	Aldo Keto reductase
HCR84_RS09955	COG1960	acyl-CoA dehydrogenase activity
HCR84_RS09965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCR84_RS09975	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCR84_RS09980	COG0022	dehydrogenase e1 component
HCR84_RS09990	COG1185	polyribonucleotide nucleotidyltransferase activity
HCR84_RS09995	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCR84_RS10000	COG3594	Acyltransferase
HCR84_RS10010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCR84_RS10040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCR84_RS10050	COG0626	cystathionine gamma-synthase activity
HCR84_RS10055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCR84_RS10060	COG0545	Peptidyl-prolyl cis-trans isomerase
HCR84_RS10065	COG1027	Aspartate ammonia-lyase
HCR84_RS10070	COG2252	PERMEase
HCR84_RS10075	COG2233	PERMEase
HCR84_RS10110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCR84_RS10115	COG1464	Belongs to the NlpA lipoprotein family
HCR84_RS10120	COG2011	ABC-type metal ion transport system permease component
HCR84_RS10125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCR84_RS10140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCR84_RS10155	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS10160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCR84_RS10180	COG0196	riboflavin kinase activity
HCR84_RS10195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCR84_RS10210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCR84_RS10215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCR84_RS10225	COG0195	Participates in both transcription termination and antitermination
HCR84_RS10230	COG0442	prolyl-tRNA aminoacylation
HCR84_RS10260	COG0714	Associated with various cellular activities
HCR84_RS10265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCR84_RS10280	COG0183	Belongs to the thiolase family
HCR84_RS10290	COG2197	response regulator
HCR84_RS10295	COG4585	Histidine kinase
HCR84_RS10300	COG0477	Major facilitator Superfamily
HCR84_RS10305	COG0750	zinc metalloprotease
HCR84_RS10310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCR84_RS10315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCR84_RS10340	COG0686	Belongs to the AlaDH PNT family
HCR84_RS10350	COG0631	protein serine/threonine phosphatase activity
HCR84_RS10375	COG0667	Aldo Keto reductase
HCR84_RS10385	COG3022	response to hydroperoxide
HCR84_RS10390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCR84_RS10395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCR84_RS10400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCR84_RS10405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCR84_RS10410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCR84_RS10415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCR84_RS10420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCR84_RS10425	COG0356	it plays a direct role in the translocation of protons across the membrane
HCR84_RS10435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCR84_RS10445	COG2890	protein-(glutamine-N5) methyltransferase activity
HCR84_RS10455	COG1045	serine acetyltransferase
HCR84_RS10460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCR84_RS10470	COG0083	homoserine kinase activity
HCR84_RS10475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCR84_RS10480	COG0460	homoserine dehydrogenase
HCR84_RS10495	COG0018	arginyl-trna synthetase
HCR84_RS10505	COG1305	Transglutaminase-like
HCR84_RS10525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCR84_RS10530	COG1842	Phage shock protein A
HCR84_RS10555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCR84_RS10560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCR84_RS10580	COG0656	L-ascorbic acid biosynthetic process
HCR84_RS10590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCR84_RS10595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCR84_RS10595	COG0596	Alpha beta hydrolase
HCR84_RS10600	COG0747	negative chemotaxis
HCR84_RS10605	COG0601	transmembrane transport
HCR84_RS10610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCR84_RS10615	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS10620	COG4608	Belongs to the ABC transporter superfamily
HCR84_RS10625	COG0154	amidase activity
HCR84_RS10635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCR84_RS10640	COG3340	Belongs to the peptidase S51 family
HCR84_RS10645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HCR84_RS10650	COG4221	oxidoreductase activity
HCR84_RS10665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCR84_RS10700	COG1902	pentaerythritol trinitrate reductase activity
HCR84_RS10705	COG1253	flavin adenine dinucleotide binding
HCR84_RS10720	COG0567	Dehydrogenase, E1 component
HCR84_RS10720	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCR84_RS10725	COG0025	NhaP-type Na H and K H
HCR84_RS10735	COG1595	DNA-templated transcription, initiation
HCR84_RS10740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCR84_RS10745	COG1162	GTPase activity
HCR84_RS10795	COG0653	protein targeting
HCR84_RS10800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCR84_RS10810	COG5401	PFAM Sporulation and spore germination
HCR84_RS10815	COG5000	phosphorelay sensor kinase activity
HCR84_RS10815	COG5002	protein histidine kinase activity
HCR84_RS10840	COG0714	Associated with various cellular activities
HCR84_RS10870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCR84_RS10875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCR84_RS10910	COG1643	Atp-dependent helicase
HCR84_RS10940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCR84_RS10945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCR84_RS10950	COG1780	Probably involved in ribonucleotide reductase function
HCR84_RS10975	COG0477	Major facilitator Superfamily
HCR84_RS10980	COG0542	response to heat
HCR84_RS11035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCR84_RS11095	COG1278	Cold shock
HCR84_RS11110	COG1061	Type III restriction enzyme res subunit
HCR84_RS11125	COG0745	RESPONSE REGULATOR receiver
HCR84_RS11130	COG2205	protein histidine kinase activity
HCR84_RS11140	COG0459	protein refolding
HCR84_RS11155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCR84_RS11180	COG3842	ATPase activity
HCR84_RS11190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCR84_RS11195	COG0215	cysteine-tRNA ligase activity
HCR84_RS11200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCR84_RS11200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCR84_RS11215	COG0745	RESPONSE REGULATOR receiver
HCR84_RS11220	COG5002	protein histidine kinase activity
HCR84_RS11230	COG0588	phosphoglycerate mutase activity
HCR84_RS11240	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HCR84_RS11250	COG0745	RESPONSE REGULATOR receiver
HCR84_RS11255	COG0456	acetyltransferase
HCR84_RS11260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCR84_RS11280	COG0581	inorganic phosphate transmembrane transporter activity
HCR84_RS11285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCR84_RS11310	COG0500	methyltransferase
HCR84_RS11315	COG1132	(ABC) transporter
HCR84_RS11320	COG0028	Belongs to the TPP enzyme family
HCR84_RS11325	COG3971	2-oxopent-4-enoate hydratase activity
HCR84_RS11335	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCR84_RS11365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HCR84_RS11370	COG1396	sequence-specific DNA binding
HCR84_RS11375	COG1335	isochorismatase
HCR84_RS11380	COG2027	D-alanyl-D-alanine carboxypeptidase
HCR84_RS11390	COG2017	converts alpha-aldose to the beta-anomer
HCR84_RS11410	COG0470	DNA polymerase III
HCR84_RS11420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCR84_RS11425	COG1754	DNA topoisomerase type I activity
HCR84_RS11425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCR84_RS11455	COG2072	flavoprotein involved in K transport
HCR84_RS11480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCR84_RS11485	COG2852	Protein conserved in bacteria
HCR84_RS11495	COG1472	Belongs to the glycosyl hydrolase 3 family
HCR84_RS11510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCR84_RS11530	COG4214	carbohydrate transport
HCR84_RS11540	COG4213	ABC transporter substrate-binding protein
HCR84_RS11545	COG1940	carbohydrate kinase activity
HCR84_RS11560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCR84_RS11565	COG1929	Belongs to the glycerate kinase type-1 family
HCR84_RS11570	COG3960	tartronate-semialdehyde synthase activity
HCR84_RS11575	COG2084	Dehydrogenase
HCR84_RS11580	COG3622	Belongs to the hyi family
HCR84_RS11600	COG1414	Transcriptional regulator
HCR84_RS11605	COG0183	Belongs to the thiolase family
HCR84_RS11610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCR84_RS11620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCR84_RS11625	COG2267	carboxylic ester hydrolase activity
HCR84_RS11630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCR84_RS11640	COG3485	protocatechuate 3,4-dioxygenase
HCR84_RS11645	COG1414	Transcriptional regulator
HCR84_RS11655	COG0747	negative chemotaxis
HCR84_RS11660	COG0601	transmembrane transport
HCR84_RS11665	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS11675	COG0583	DNA-binding transcription factor activity
HCR84_RS11685	COG0657	acetylesterase activity
HCR84_RS11690	COG3250	beta-galactosidase activity
HCR84_RS11700	COG1414	Transcriptional regulator
HCR84_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS11720	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCR84_RS11725	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCR84_RS11735	COG3250	beta-galactosidase activity
HCR84_RS11745	COG1309	transcriptional regulator
HCR84_RS11755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCR84_RS11760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCR84_RS11765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HCR84_RS11795	COG3257	ureidoglycine aminohydrolase activity
HCR84_RS11805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCR84_RS11815	COG1414	Transcriptional regulator
HCR84_RS11820	COG4221	oxidoreductase activity
HCR84_RS11830	COG2442	InterPro IPR007367
HCR84_RS11835	COG2233	PERMEase
HCR84_RS11895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCR84_RS11905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCR84_RS11915	COG0463	Glycosyl transferase, family 2
HCR84_RS11930	COG2826	transposase and inactivated derivatives, IS30 family
HCR84_RS11940	COG0110	maltose O-acetyltransferase activity
HCR84_RS11965	COG0297	glycogen (starch) synthase activity
HCR84_RS11970	COG0297	glycogen (starch) synthase activity
HCR84_RS11975	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HCR84_RS11980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCR84_RS12010	COG0489	protein tyrosine kinase activity
HCR84_RS12025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HCR84_RS12035	COG1088	dTDP-glucose 4,6-dehydratase activity
HCR84_RS12055	COG0640	Transcriptional regulator
HCR84_RS12065	COG1136	(ABC) transporter
HCR84_RS12080	COG2197	response regulator
HCR84_RS12095	COG0579	oxidoreductase
HCR84_RS12100	COG0745	RESPONSE REGULATOR receiver
HCR84_RS12110	COG2205	protein histidine kinase activity
HCR84_RS12110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCR84_RS12110	COG0784	Response regulator, receiver
HCR84_RS12110	COG2198	Histidine kinase
HCR84_RS12115	COG0745	RESPONSE REGULATOR receiver
HCR84_RS12145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCR84_RS12155	COG0473	3-isopropylmalate dehydrogenase activity
HCR84_RS12155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HCR84_RS12165	COG1024	Enoyl-CoA hydratase
HCR84_RS12170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCR84_RS12180	COG0395	ABC-type sugar transport system, permease component
HCR84_RS12185	COG1175	transmembrane transport
HCR84_RS12195	COG1802	Transcriptional regulator
HCR84_RS12210	COG0569	domain protein
HCR84_RS12215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCR84_RS12225	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HCR84_RS12235	COG1256	bacterial-type flagellum assembly
HCR84_RS12235	COG4786	Flagellar basal body rod
HCR84_RS12250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCR84_RS12255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCR84_RS12260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCR84_RS12285	COG1677	Flagellar hook-basal body complex protein FliE
HCR84_RS12290	COG1766	The M ring may be actively involved in energy transduction
HCR84_RS12295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCR84_RS12305	COG1157	protein secretion by the type III secretion system
HCR84_RS12325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HCR84_RS12355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCR84_RS12355	COG1776	CheC inhibitor of MCP methylation
HCR84_RS12375	COG1684	flagellar biosynthetic protein fliR
HCR84_RS12380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCR84_RS12385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCR84_RS12395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCR84_RS12400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCR84_RS12405	COG1216	Glycosyl transferase, family 2
HCR84_RS12415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCR84_RS12425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCR84_RS12455	COG3585	molybdate ion transport
HCR84_RS12470	COG0315	cyclic pyranopterin monophosphate synthase activity
HCR84_RS12520	COG0314	molybdopterin synthase activity
HCR84_RS12525	COG0315	cyclic pyranopterin monophosphate synthase activity
HCR84_RS12525	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCR84_RS12540	COG1140	nitrate reductase beta subunit
HCR84_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS12575	COG2186	Transcriptional regulator
HCR84_RS12585	COG3119	arylsulfatase activity
HCR84_RS12625	COG0277	FAD linked oxidase domain protein
HCR84_RS12630	COG0671	phosphoesterase, PA-phosphatase related
HCR84_RS12640	COG1472	Belongs to the glycosyl hydrolase 3 family
HCR84_RS12645	COG0395	ABC-type sugar transport system, permease component
HCR84_RS12650	COG1175	transmembrane transport
HCR84_RS12675	COG2814	Major facilitator Superfamily
HCR84_RS12685	COG1609	Transcriptional regulator
HCR84_RS12690	COG1501	Belongs to the glycosyl hydrolase 31 family
HCR84_RS12695	COG0395	ABC-type sugar transport system, permease component
HCR84_RS12700	COG1175	transmembrane transport
HCR84_RS12710	COG3458	cephalosporin-C deacetylase activity
HCR84_RS12720	COG0640	Transcriptional regulator
HCR84_RS12740	COG0673	inositol 2-dehydrogenase activity
HCR84_RS12765	COG1653	transport
HCR84_RS12770	COG1175	transmembrane transport
HCR84_RS12775	COG0395	ABC-type sugar transport system, permease component
HCR84_RS12780	COG3534	alpha-L-arabinofuranosidase
HCR84_RS12795	COG1673	EVE domain
HCR84_RS12805	COG0513	Belongs to the DEAD box helicase family
HCR84_RS12840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCR84_RS12875	COG1201	RNA secondary structure unwinding
HCR84_RS12880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCR84_RS12890	COG0640	Transcriptional regulator
HCR84_RS12900	COG1957	nucleoside hydrolase
HCR84_RS12925	COG0657	acetylesterase activity
HCR84_RS12950	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS12955	COG0006	proline dipeptidase activity
HCR84_RS12960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCR84_RS12980	COG1525	nuclease
HCR84_RS12980	COG4085	toxin activity
HCR84_RS12980	COG0737	Belongs to the 5'-nucleotidase family
HCR84_RS12990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCR84_RS12995	COG0248	Ppx GppA phosphatase
HCR84_RS13025	COG3655	Transcriptional regulator
HCR84_RS13030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCR84_RS13045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCR84_RS13070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCR84_RS13075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCR84_RS13080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCR84_RS13085	COG1122	ATPase activity
HCR84_RS13090	COG1268	BioY protein
HCR84_RS13100	COG0302	gtp cyclohydrolase
HCR84_RS13105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCR84_RS13115	COG0037	tRNA processing
HCR84_RS13120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCR84_RS13125	COG0739	heme binding
HCR84_RS13125	COG0741	lytic transglycosylase activity
HCR84_RS13125	COG1196	nuclear chromosome segregation
HCR84_RS13150	COG0477	Major facilitator Superfamily
HCR84_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS13175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HCR84_RS13190	COG1215	transferase activity, transferring glycosyl groups
HCR84_RS13195	COG0438	transferase activity, transferring glycosyl groups
HCR84_RS13195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCR84_RS13235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCR84_RS13240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCR84_RS13245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCR84_RS13255	COG0438	transferase activity, transferring glycosyl groups
HCR84_RS13260	COG0297	glycogen (starch) synthase activity
HCR84_RS13280	COG0438	transferase activity, transferring glycosyl groups
HCR84_RS13310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCR84_RS13320	COG0667	Aldo Keto reductase
HCR84_RS13335	COG0514	ATP-dependent DNA helicase (RecQ)
HCR84_RS13370	COG1122	ATPase activity
HCR84_RS13375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCR84_RS13405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCR84_RS13420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCR84_RS13425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCR84_RS13430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCR84_RS13435	COG0513	Belongs to the DEAD box helicase family
HCR84_RS13440	COG2261	transglycosylase associated protein
HCR84_RS13450	COG2197	response regulator
HCR84_RS13475	COG2986	histidine ammonia-lyase
HCR84_RS13480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HCR84_RS13485	COG1228	amidohydrolase
HCR84_RS13495	COG0010	Belongs to the arginase family
HCR84_RS13515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCR84_RS13550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCR84_RS13565	COG0151	Belongs to the GarS family
HCR84_RS13585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCR84_RS13590	COG2259	Doxx family
HCR84_RS13595	COG2514	catechol 2,3-dioxygenase activity
HCR84_RS13610	COG2197	response regulator
HCR84_RS13615	COG4585	Histidine kinase
HCR84_RS13620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCR84_RS13625	COG0047	phosphoribosylformylglycinamidine synthase activity
HCR84_RS13645	COG2860	membrane
HCR84_RS13655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCR84_RS13660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCR84_RS13665	COG0477	Major facilitator Superfamily
HCR84_RS13675	COG2409	Drug exporters of the RND superfamily
HCR84_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS13740	COG1605	Chorismate mutase
HCR84_RS13740	COG0287	Prephenate dehydrogenase
HCR84_RS13750	COG1136	(ABC) transporter
HCR84_RS13770	COG3387	PFAM Glycoside hydrolase 15-related
HCR84_RS13775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCR84_RS13785	COG0137	argininosuccinate synthase activity
HCR84_RS13790	COG1546	Belongs to the CinA family
HCR84_RS13790	COG1058	Belongs to the CinA family
HCR84_RS13805	COG1174	glycine betaine transport
HCR84_RS13825	COG1321	iron dependent repressor
HCR84_RS13835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCR84_RS13850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCR84_RS13855	COG2409	Drug exporters of the RND superfamily
HCR84_RS13875	COG0596	Alpha beta hydrolase
HCR84_RS13905	COG2197	response regulator
HCR84_RS13920	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS13925	COG4152	abc transporter atp-binding protein
HCR84_RS13950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCR84_RS13965	COG4608	Belongs to the ABC transporter superfamily
HCR84_RS13970	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS13975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCR84_RS13980	COG0601	transmembrane transport
HCR84_RS13990	COG2186	Transcriptional regulator
HCR84_RS14000	COG2197	response regulator
HCR84_RS14005	COG4585	Histidine kinase
HCR84_RS14010	COG0542	response to heat
HCR84_RS14020	COG2197	response regulator
HCR84_RS14025	COG4585	Histidine kinase
HCR84_RS14040	COG0477	Major facilitator Superfamily
HCR84_RS14060	COG0435	Glutathione S-transferase
HCR84_RS14070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCR84_RS14075	COG0673	inositol 2-dehydrogenase activity
HCR84_RS14100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCR84_RS14105	COG2813	Specifically methylates the guanine in position
HCR84_RS14120	COG0789	Transcriptional regulator
HCR84_RS14125	COG0484	heat shock protein binding
HCR84_RS14130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCR84_RS14135	COG0443	Heat shock 70 kDa protein
HCR84_RS14185	COG2197	response regulator
HCR84_RS14205	COG2186	Transcriptional regulator
HCR84_RS14220	COG4948	Mandelate Racemase Muconate Lactonizing
HCR84_RS14225	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCR84_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS14240	COG1131	(ABC) transporter
HCR84_RS14255	COG0740	serine-type endopeptidase activity
HCR84_RS14260	COG0740	serine-type endopeptidase activity
HCR84_RS14265	COG1396	sequence-specific DNA binding
HCR84_RS14270	COG0717	Belongs to the dCTP deaminase family
HCR84_RS14300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCR84_RS14305	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCR84_RS14335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCR84_RS14350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCR84_RS14370	COG0776	regulation of translation
HCR84_RS14375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCR84_RS14380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCR84_RS14385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCR84_RS14395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCR84_RS14400	COG1121	(ABC) transporter
HCR84_RS14420	COG0517	IMP dehydrogenase activity
HCR84_RS14420	COG4175	Glycine betaine
HCR84_RS14425	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCR84_RS14430	COG0022	dehydrogenase e1 component
HCR84_RS14440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCR84_RS14445	COG1950	PFAM Membrane protein of
HCR84_RS14460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCR84_RS14465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCR84_RS14475	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCR84_RS14510	COG0305	Participates in initiation and elongation during chromosome replication
HCR84_RS14515	COG0359	binds to the 23S rRNA
HCR84_RS14520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCR84_RS14530	COG0360	Binds together with S18 to 16S ribosomal RNA
HCR84_RS14535	COG1653	transport
HCR84_RS14540	COG0395	ABC-type sugar transport system, permease component
HCR84_RS14545	COG1175	transmembrane transport
HCR84_RS14550	COG0246	Mannitol dehydrogenase
HCR84_RS14555	COG0395	ABC-type sugar transport system, permease component
HCR84_RS14565	COG3842	ATPase activity
HCR84_RS14580	COG1904	glucuronate isomerase
HCR84_RS14585	COG4948	Mandelate Racemase Muconate Lactonizing
HCR84_RS14590	COG0617	tRNA 3'-terminal CCA addition
HCR84_RS14595	COG0659	secondary active sulfate transmembrane transporter activity
HCR84_RS14600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCR84_RS14605	COG0028	Belongs to the TPP enzyme family
HCR84_RS14630	COG2814	Major facilitator Superfamily
HCR84_RS14645	COG2376	Dihydroxyacetone kinase
HCR84_RS14650	COG0698	ribose 5-phosphate isomerase
HCR84_RS14655	COG0149	triose-phosphate isomerase activity
HCR84_RS14665	COG1024	Enoyl-CoA hydratase
HCR84_RS14665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCR84_RS14675	COG2610	gluconate transmembrane transporter activity
HCR84_RS14700	COG0395	ABC-type sugar transport system, permease component
HCR84_RS14740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCR84_RS14750	COG0747	negative chemotaxis
HCR84_RS14755	COG2272	Belongs to the type-B carboxylesterase lipase family
HCR84_RS14780	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS14795	COG0574	Belongs to the PEP-utilizing enzyme family
HCR84_RS14795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCR84_RS14810	COG1472	Belongs to the glycosyl hydrolase 3 family
HCR84_RS14820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HCR84_RS14830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCR84_RS14845	COG2076	Multidrug Resistance protein
HCR84_RS14865	COG0640	Transcriptional regulator
HCR84_RS14885	COG2132	Multicopper oxidase
HCR84_RS14900	COG1362	aminopeptidase activity
HCR84_RS14920	COG2217	Heavy metal translocating P-type atpase
HCR84_RS14930	COG1937	Protein conserved in bacteria
HCR84_RS14940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCR84_RS14945	COG0640	Transcriptional regulator
HCR84_RS14950	COG0346	lactoylglutathione lyase activity
HCR84_RS14960	COG1122	ATPase activity
HCR84_RS14965	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS14985	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCR84_RS14985	COG1902	pentaerythritol trinitrate reductase activity
HCR84_RS14995	COG0366	Alpha amylase catalytic
HCR84_RS15000	COG2154	pterin-4-alpha-carbinolamine dehydratase
HCR84_RS15020	COG1131	(ABC) transporter
HCR84_RS15050	COG0419	ATPase involved in DNA repair
HCR84_RS15080	COG1733	regulation of RNA biosynthetic process
HCR84_RS15090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCR84_RS15100	COG1414	Transcriptional regulator
HCR84_RS15105	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HCR84_RS15120	COG0800	Aldolase
HCR84_RS15160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCR84_RS15170	COG1349	DNA-binding transcription factor activity
HCR84_RS15175	COG0395	ABC-type sugar transport system, permease component
HCR84_RS15190	COG1349	DNA-binding transcription factor activity
HCR84_RS15195	COG1070	Carbohydrate kinase
HCR84_RS15200	COG0494	nUDIX hydrolase
HCR84_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS15230	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS15240	COG0601	transmembrane transport
HCR84_RS15245	COG4608	Belongs to the ABC transporter superfamily
HCR84_RS15250	COG0747	negative chemotaxis
HCR84_RS15300	COG2066	Belongs to the glutaminase family
HCR84_RS15300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HCR84_RS15320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCR84_RS15345	COG2226	methyltransferase
HCR84_RS15360	COG1966	Carbon starvation protein
HCR84_RS15375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCR84_RS15380	COG1846	Transcriptional regulator
HCR84_RS15385	COG1764	response to oxidative stress
HCR84_RS15395	COG3119	arylsulfatase activity
HCR84_RS15400	COG3119	arylsulfatase activity
HCR84_RS15420	COG1940	carbohydrate kinase activity
HCR84_RS15425	COG3507	Belongs to the glycosyl hydrolase 43 family
HCR84_RS15430	COG1309	transcriptional regulator
HCR84_RS15435	COG4221	oxidoreductase activity
HCR84_RS15445	COG0395	ABC-type sugar transport system, permease component
HCR84_RS15450	COG1175	transmembrane transport
HCR84_RS15455	COG1653	transport
HCR84_RS15485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCR84_RS15490	COG1739	Uncharacterized protein family UPF0029
HCR84_RS15530	COG1595	DNA-templated transcription, initiation
HCR84_RS15535	COG2169	Transcriptional regulator
HCR84_RS15535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCR84_RS15540	COG2818	Glycosylase
HCR84_RS15550	COG1846	Transcriptional regulator
HCR84_RS15595	COG3119	arylsulfatase activity
HCR84_RS15610	COG1653	transport
HCR84_RS15615	COG1175	transmembrane transport
HCR84_RS15620	COG0395	ABC-type sugar transport system, permease component
HCR84_RS15625	COG3119	arylsulfatase activity
HCR84_RS15625	COG3408	Glycogen debranching enzyme
HCR84_RS15655	COG2807	transmembrane transport
HCR84_RS15665	COG0702	epimerase
HCR84_RS15670	COG1309	transcriptional regulator
HCR84_RS15690	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS15695	COG3938	Belongs to the proline racemase family
HCR84_RS15700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCR84_RS15720	COG1802	Transcriptional regulator
HCR84_RS15725	COG0006	proline dipeptidase activity
HCR84_RS15735	COG4608	Belongs to the ABC transporter superfamily
HCR84_RS15740	COG0444	Belongs to the ABC transporter superfamily
HCR84_RS15745	COG0601	transmembrane transport
HCR84_RS15750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCR84_RS15755	COG0747	negative chemotaxis
HCR84_RS15775	COG1115	amino acid carrier protein
HCR84_RS15780	COG3938	Belongs to the proline racemase family
HCR84_RS15795	COG1609	Transcriptional regulator
HCR84_RS15810	COG0395	ABC-type sugar transport system, permease component
HCR84_RS15815	COG1175	transmembrane transport
HCR84_RS15830	COG1609	Transcriptional regulator
HCR84_RS15845	COG2814	Major facilitator Superfamily
HCR84_RS15860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCR84_RS15860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCR84_RS15860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCR84_RS15865	COG1105	Belongs to the carbohydrate kinase PfkB family
HCR84_RS15870	COG1349	DNA-binding transcription factor activity
HCR84_RS15885	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS15900	COG1024	Enoyl-CoA hydratase
HCR84_RS15905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCR84_RS15910	COG1053	succinate dehydrogenase
HCR84_RS15915	COG0477	Major facilitator Superfamily
HCR84_RS15920	COG1396	sequence-specific DNA binding
HCR84_RS15945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCR84_RS15975	COG0596	Alpha beta hydrolase
HCR84_RS15985	COG3250	beta-galactosidase activity
HCR84_RS15990	COG0395	ABC-type sugar transport system, permease component
HCR84_RS15995	COG4209	transmembrane transport
HCR84_RS16000	COG1653	transport
HCR84_RS16005	COG1609	Transcriptional regulator
HCR84_RS16015	COG2188	Transcriptional regulator
HCR84_RS16020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCR84_RS16025	COG1869	D-ribose catabolic process
HCR84_RS16030	COG1129	ABC transporter
HCR84_RS16040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS16045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCR84_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS16065	COG2376	Dihydroxyacetone kinase
HCR84_RS16090	COG1129	ABC transporter
HCR84_RS16100	COG1349	DNA-binding transcription factor activity
HCR84_RS16105	COG0434	BtpA family
HCR84_RS16125	COG4221	oxidoreductase activity
HCR84_RS16130	COG0537	adenosine 5'-monophosphoramidase activity
HCR84_RS16140	COG3311	Transcriptional regulator
HCR84_RS16145	COG1569	PIN domain
HCR84_RS16155	COG2188	Transcriptional regulator
HCR84_RS16165	COG1175	transmembrane transport
HCR84_RS16170	COG0395	ABC-type sugar transport system, permease component
HCR84_RS16190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCR84_RS16225	COG0010	Belongs to the arginase family
HCR84_RS16235	COG0765	amino acid transport
HCR84_RS16240	COG0765	amino acid transport
HCR84_RS16245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCR84_RS16250	COG1126	abc transporter atp-binding protein
HCR84_RS16265	COG0477	Major facilitator Superfamily
HCR84_RS16270	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCR84_RS16300	COG1414	Transcriptional regulator
HCR84_RS16310	COG1063	alcohol dehydrogenase
HCR84_RS16315	COG1802	Transcriptional regulator
HCR84_RS16325	COG1063	alcohol dehydrogenase
HCR84_RS16330	COG3833	ABC-type maltose transport systems, permease component
HCR84_RS16345	COG0205	6-phosphofructokinase activity
HCR84_RS16350	COG1012	belongs to the aldehyde dehydrogenase family
HCR84_RS16365	COG3684	Belongs to the aldolase LacD family
HCR84_RS16385	COG1126	abc transporter atp-binding protein
HCR84_RS16390	COG0765	amino acid transport
HCR84_RS16395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCR84_RS16405	COG0686	Belongs to the AlaDH PNT family
HCR84_RS16425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCR84_RS16440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCR84_RS16450	COG1397	ADP-ribosylglycohydrolase
HCR84_RS16455	COG2188	Transcriptional regulator
HCR84_RS16470	COG3958	Transketolase
HCR84_RS16475	COG3959	Transketolase, thiamine diphosphate binding domain
HCR84_RS16480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCR84_RS16490	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HCR84_RS16495	COG2814	Major facilitator Superfamily
HCR84_RS16530	COG3177	Filamentation induced by cAMP protein fic
HCR84_RS16540	COG0477	Major facilitator Superfamily
HCR84_RS16545	COG2186	Transcriptional regulator
HCR84_RS16550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCR84_RS16565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS16570	COG1129	ABC transporter
HCR84_RS16575	COG1879	ABC-type sugar transport system periplasmic component
HCR84_RS16590	COG0673	inositol 2-dehydrogenase activity
HCR84_RS16600	COG0395	ABC-type sugar transport system, permease component
HCR84_RS16605	COG1175	transmembrane transport
HCR84_RS16610	COG1653	transport
HCR84_RS16615	COG1609	Transcriptional regulator
HCR84_RS16620	COG3345	alpha-galactosidase
HCR84_RS16635	COG1653	transport
HCR84_RS16640	COG0395	ABC-type sugar transport system, permease component
HCR84_RS16645	COG4209	transmembrane transport
HCR84_RS16650	COG2186	Transcriptional regulator
HCR84_RS16655	COG4948	Mandelate Racemase Muconate Lactonizing
HCR84_RS16665	COG2357	RelA SpoT domain protein
HCR84_RS16715	COG0251	oxidation-reduction process
HCR84_RS16720	COG0477	Major facilitator Superfamily
HCR84_RS16760	COG0494	nUDIX hydrolase
HCR84_RS16775	COG3537	Alpha-1,2-mannosidase
HCR84_RS16790	COG0640	Transcriptional regulator
HCR84_RS16800	COG2239	Acts as a magnesium transporter
HCR84_RS16820	COG0395	ABC-type sugar transport system, permease component
HCR84_RS16825	COG1175	transmembrane transport
HCR84_RS16830	COG2182	Extracellular solute-binding protein
HCR84_RS16835	COG2188	Transcriptional regulator
HCR84_RS16855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCR84_RS16860	COG0395	ABC-type sugar transport system, permease component
HCR84_RS16870	COG1653	transport
HCR84_RS16875	COG1846	Transcriptional regulator
HCR84_RS16905	COG1486	melibiose metabolic process
HCR84_RS16920	COG0477	Major facilitator Superfamily
HCR84_RS16925	COG2161	toxin-antitoxin pair type II binding
HCR84_RS16930	COG4115	mRNA cleavage
HCR84_RS16935	COG4552	Acetyltransferase involved in intracellular survival and related
HCR84_RS16970	COG0431	NADPH-dependent FMN reductase
HCR84_RS16985	COG2160	L-arabinose isomerase activity
HCR84_RS17010	COG2814	Major facilitator Superfamily
HCR84_RS17035	COG0640	Transcriptional regulator
HCR84_RS17050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCR84_RS17065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCR84_RS17070	COG0297	glycogen (starch) synthase activity
HCR84_RS17090	COG0626	cystathionine gamma-synthase activity
HCR84_RS17110	COG3739	integral membrane protein
HCR84_RS17120	COG1063	alcohol dehydrogenase
HCR84_RS17135	COG0492	ferredoxin-NADP+ reductase activity
HCR84_RS17140	COG2226	methyltransferase
HCR84_RS17150	COG0300	oxidoreductase activity
HCR84_RS17155	COG1309	transcriptional regulator
HCR84_RS17170	COG0494	nUDIX hydrolase
HCR84_RS17175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCR84_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
HCR84_RS17210	COG0183	Belongs to the thiolase family
HCR84_RS17220	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCR84_RS17230	COG0069	glutamate synthase activity
HCR84_RS17235	COG1254	Belongs to the acylphosphatase family
HCR84_RS17240	COG2188	Transcriptional regulator
HCR84_RS17275	COG0673	inositol 2-dehydrogenase activity
HCR84_RS17280	COG1942	4-Oxalocrotonate Tautomerase
HCR84_RS17285	COG1082	Xylose isomerase domain protein TIM barrel
HCR84_RS17300	COG2814	Major facilitator Superfamily
HCR84_RS17310	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCR84_RS17320	COG0673	inositol 2-dehydrogenase activity
HCR84_RS17325	COG1082	Xylose isomerase domain protein TIM barrel
HCR84_RS17340	COG3962	Belongs to the TPP enzyme family
HCR84_RS17345	COG3718	enzyme involved in inositol metabolism
HCR84_RS17375	COG0484	heat shock protein binding
HCR84_RS17385	COG1846	Transcriptional regulator
HCR84_RS17400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCR84_RS17405	COG1672	PFAM Archaeal ATPase
HCR84_RS17405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HCR84_RS17415	COG2890	protein-(glutamine-N5) methyltransferase activity
HCR84_RS17430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCR84_RS17450	COG0492	ferredoxin-NADP+ reductase activity
HCR84_RS17455	COG3118	belongs to the thioredoxin family
HCR84_RS17460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCR84_RS17465	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCR84_RS17475	COG1192	Involved in chromosome partitioning
HCR84_RS17480	COG0357	Ribosomal RNA small subunit methyltransferase G
HCR84_RS17490	COG0706	membrane insertase activity
HCR84_RS17495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCR84_RS17500	COG0594	ribonuclease P activity
HCR84_RS17505	COG0230	Belongs to the bacterial ribosomal protein bL34 family