locus-tag	class	description
MICNX66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MICNX66_RS00010	COG0592	DNA-directed DNA polymerase activity
MICNX66_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MICNX66_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MICNX66_RS00025	COG0187	DNA topoisomerase II activity
MICNX66_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MICNX66_RS00040	COG3850	Histidine kinase
MICNX66_RS00045	COG2197	response regulator
MICNX66_RS00095	COG0705	Rhomboid family
MICNX66_RS00105	COG3764	Sortase (surface protein transpeptidase)
MICNX66_RS00120	COG0515	serine threonine protein kinase
MICNX66_RS00120	COG2815	serine threonine protein kinase
MICNX66_RS00125	COG0515	serine threonine protein kinase
MICNX66_RS00130	COG0768	penicillin binding
MICNX66_RS00145	COG1716	ATPase activity
MICNX66_RS00150	COG1716	ATPase activity
MICNX66_RS00180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MICNX66_RS00190	COG1609	Transcriptional regulator
MICNX66_RS00195	COG0477	Major facilitator Superfamily
MICNX66_RS00200	COG0387	Pfam Sodium calcium exchanger
MICNX66_RS00255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MICNX66_RS00260	COG1278	Cold shock
MICNX66_RS00265	COG0546	phosphoglycolate phosphatase activity
MICNX66_RS00275	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MICNX66_RS00290	COG2197	response regulator
MICNX66_RS00305	COG0738	Major facilitator superfamily
MICNX66_RS00320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MICNX66_RS00320	COG2111	Na H antiporter
MICNX66_RS00330	COG0651	ATP synthesis coupled electron transport
MICNX66_RS00345	COG1320	monovalent cation:proton antiporter activity
MICNX66_RS00440	COG0714	Associated with various cellular activities
MICNX66_RS00445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MICNX66_RS00455	COG0697	spore germination
MICNX66_RS00475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MICNX66_RS00490	COG1268	BioY protein
MICNX66_RS00495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MICNX66_RS00505	COG1125	glycine betaine transport
MICNX66_RS00505	COG0517	IMP dehydrogenase activity
MICNX66_RS00510	COG1174	glycine betaine transport
MICNX66_RS00515	COG1174	glycine betaine transport
MICNX66_RS00530	COG1605	Chorismate mutase
MICNX66_RS00530	COG0287	Prephenate dehydrogenase
MICNX66_RS00535	COG0318	PFAM AMP-dependent synthetase and ligase
MICNX66_RS00575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MICNX66_RS00585	COG1105	Belongs to the carbohydrate kinase PfkB family
MICNX66_RS00595	COG1349	DNA-binding transcription factor activity
MICNX66_RS00645	COG1131	(ABC) transporter
MICNX66_RS00655	COG2813	Specifically methylates the guanine in position
MICNX66_RS00665	COG4176	ABC-type proline glycine betaine transport system permease component
MICNX66_RS00675	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MICNX66_RS00710	COG2197	response regulator
MICNX66_RS00720	COG1136	(ABC) transporter
MICNX66_RS00720	COG0577	efflux transmembrane transporter activity
MICNX66_RS00735	COG2197	response regulator
MICNX66_RS00765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MICNX66_RS00770	COG3340	Belongs to the peptidase S51 family
MICNX66_RS00795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MICNX66_RS00830	COG1404	Belongs to the peptidase S8 family
MICNX66_RS00835	COG0598	Magnesium transport protein CorA
MICNX66_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS00850	COG0673	inositol 2-dehydrogenase activity
MICNX66_RS00855	COG1940	carbohydrate kinase activity
MICNX66_RS00865	COG1175	transmembrane transport
MICNX66_RS00870	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS00885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MICNX66_RS00905	COG1802	Transcriptional regulator
MICNX66_RS00915	COG0747	negative chemotaxis
MICNX66_RS00920	COG0601	transmembrane transport
MICNX66_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS00960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MICNX66_RS00975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MICNX66_RS01005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MICNX66_RS01010	COG3639	organic phosphonate transmembrane transporter activity
MICNX66_RS01035	COG2409	Drug exporters of the RND superfamily
MICNX66_RS01050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MICNX66_RS01070	COG2764	glyoxalase bleomycin resistance protein dioxygenase
MICNX66_RS01095	COG2378	regulation of single-species biofilm formation
MICNX66_RS01140	COG3795	YCII-related domain
MICNX66_RS01190	COG1201	RNA secondary structure unwinding
MICNX66_RS01230	COG0659	secondary active sulfate transmembrane transporter activity
MICNX66_RS01250	COG1609	Transcriptional regulator
MICNX66_RS01255	COG1178	ABC-type Fe3 transport system permease component
MICNX66_RS01260	COG3842	ATPase activity
MICNX66_RS01265	COG1840	ABC-type Fe3 transport system, periplasmic component
MICNX66_RS01280	COG1216	Glycosyl transferase, family 2
MICNX66_RS01290	COG2188	Transcriptional regulator
MICNX66_RS01300	COG1175	transmembrane transport
MICNX66_RS01305	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS01325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MICNX66_RS01330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MICNX66_RS01335	COG0702	epimerase
MICNX66_RS01340	COG0738	Major facilitator superfamily
MICNX66_RS01365	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS01370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MICNX66_RS01370	COG0237	dephospho-CoA kinase activity
MICNX66_RS01400	COG0328	RNA-DNA hybrid ribonuclease activity
MICNX66_RS01430	COG2205	protein histidine kinase activity
MICNX66_RS01435	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS01445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MICNX66_RS01460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MICNX66_RS01480	COG0813	purine-nucleoside phosphorylase activity
MICNX66_RS01510	COG1672	PFAM Archaeal ATPase
MICNX66_RS01510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MICNX66_RS01515	COG1278	Cold shock
MICNX66_RS01525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MICNX66_RS01530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MICNX66_RS01535	COG1120	ATPase activity
MICNX66_RS01545	COG1120	ATPase activity
MICNX66_RS01550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MICNX66_RS01560	COG2267	carboxylic ester hydrolase activity
MICNX66_RS01585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MICNX66_RS01595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MICNX66_RS01605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MICNX66_RS01620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MICNX66_RS01625	COG0531	amino acid
MICNX66_RS01640	COG2026	Addiction module toxin, RelE StbE family
MICNX66_RS01645	COG2357	RelA SpoT domain protein
MICNX66_RS01665	COG0444	Belongs to the ABC transporter superfamily
MICNX66_RS01675	COG0601	transmembrane transport
MICNX66_RS01680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS01685	COG1472	Belongs to the glycosyl hydrolase 3 family
MICNX66_RS01720	COG1609	Transcriptional regulator
MICNX66_RS01725	COG0366	Alpha amylase catalytic
MICNX66_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS01740	COG0047	phosphoribosylformylglycinamidine synthase activity
MICNX66_RS01750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MICNX66_RS01760	COG1175	transmembrane transport
MICNX66_RS01765	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS01770	COG2723	6-phospho-beta-galactosidase activity
MICNX66_RS01795	COG1914	H( )-stimulated, divalent metal cation uptake system
MICNX66_RS01800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MICNX66_RS01805	COG4336	lyase activity
MICNX66_RS01810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MICNX66_RS01815	COG4770	biotin carboxylase activity
MICNX66_RS01820	COG2233	PERMEase
MICNX66_RS01825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MICNX66_RS01840	COG0765	amino acid transport
MICNX66_RS01845	COG1126	abc transporter atp-binding protein
MICNX66_RS01850	COG0151	Belongs to the GarS family
MICNX66_RS01865	COG1120	ATPase activity
MICNX66_RS01870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MICNX66_RS01875	COG4558	Periplasmic binding protein
MICNX66_RS01915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MICNX66_RS01930	COG1609	Transcriptional regulator
MICNX66_RS01940	COG1470	cell adhesion involved in biofilm formation
MICNX66_RS01940	COG0366	Alpha amylase catalytic
MICNX66_RS01990	COG0778	Nitroreductase
MICNX66_RS02005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MICNX66_RS02015	COG1175	transmembrane transport
MICNX66_RS02030	COG0673	inositol 2-dehydrogenase activity
MICNX66_RS02040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MICNX66_RS02045	COG2017	converts alpha-aldose to the beta-anomer
MICNX66_RS02050	COG0513	Belongs to the DEAD box helicase family
MICNX66_RS02070	COG1960	acyl-CoA dehydrogenase activity
MICNX66_RS02080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MICNX66_RS02085	COG1122	ATPase activity
MICNX66_RS02100	COG1966	Carbon starvation protein
MICNX66_RS02110	COG3275	phosphorelay sensor kinase activity
MICNX66_RS02125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MICNX66_RS02140	COG0514	ATP-dependent DNA helicase (RecQ)
MICNX66_RS02155	COG0519	Catalyzes the synthesis of GMP from XMP
MICNX66_RS02160	COG2815	serine threonine protein kinase
MICNX66_RS02160	COG0515	serine threonine protein kinase
MICNX66_RS02170	COG0714	Associated with various cellular activities
MICNX66_RS02205	COG1404	Belongs to the peptidase S8 family
MICNX66_RS02270	COG1404	Belongs to the peptidase S8 family
MICNX66_RS02310	COG1674	ftsk spoiiie
MICNX66_RS02340	COG0039	L-malate dehydrogenase activity
MICNX66_RS02400	COG1088	dTDP-glucose 4,6-dehydratase activity
MICNX66_RS02420	COG0438	transferase activity, transferring glycosyl groups
MICNX66_RS02440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MICNX66_RS02460	COG3206	protein involved in exopolysaccharide biosynthesis
MICNX66_RS02460	COG0489	protein tyrosine kinase activity
MICNX66_RS02485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MICNX66_RS02495	COG1309	transcriptional regulator
MICNX66_RS02510	COG3239	Fatty acid desaturase
MICNX66_RS02550	COG0596	Alpha beta hydrolase
MICNX66_RS02580	COG1401	restriction endodeoxyribonuclease activity
MICNX66_RS02605	COG0785	Cytochrome C biogenesis protein
MICNX66_RS02635	COG3336	cytochrome c oxidase
MICNX66_RS02660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MICNX66_RS02675	COG2072	flavoprotein involved in K transport
MICNX66_RS02720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MICNX66_RS02725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MICNX66_RS02730	COG0798	PFAM Bile acid sodium symporter
MICNX66_RS02735	COG3118	belongs to the thioredoxin family
MICNX66_RS02740	COG0492	ferredoxin-NADP+ reductase activity
MICNX66_RS02750	COG1937	Protein conserved in bacteria
MICNX66_RS02755	COG2217	Heavy metal translocating P-type atpase
MICNX66_RS02815	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MICNX66_RS02955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MICNX66_RS02960	COG0037	tRNA processing
MICNX66_RS02970	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MICNX66_RS02975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MICNX66_RS02980	COG0302	gtp cyclohydrolase
MICNX66_RS02985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MICNX66_RS02990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MICNX66_RS03025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MICNX66_RS03050	COG1597	lipid kinase activity
MICNX66_RS03055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MICNX66_RS03060	COG0561	phosphatase activity
MICNX66_RS03070	COG1316	TRANSCRIPTIONal
MICNX66_RS03075	COG1070	Carbohydrate kinase
MICNX66_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS03080	COG3347	Dehydrogenase
MICNX66_RS03085	COG0657	acetylesterase activity
MICNX66_RS03115	COG1129	ABC transporter
MICNX66_RS03120	COG1609	Transcriptional regulator
MICNX66_RS03140	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS03145	COG0733	neurotransmitter:sodium symporter activity
MICNX66_RS03155	COG2207	Transcriptional regulator
MICNX66_RS03155	COG3708	Transcriptional regulator
MICNX66_RS03175	COG0822	iron-sulfur transferase activity
MICNX66_RS03210	COG0583	DNA-binding transcription factor activity
MICNX66_RS03215	COG1053	succinate dehydrogenase
MICNX66_RS03225	COG1760	l-serine dehydratase
MICNX66_RS03235	COG1309	transcriptional regulator
MICNX66_RS03240	COG1131	(ABC) transporter
MICNX66_RS03250	COG1643	Atp-dependent helicase
MICNX66_RS03270	COG1131	(ABC) transporter
MICNX66_RS03275	COG1309	transcriptional regulator
MICNX66_RS03285	COG1064	alcohol dehydrogenase
MICNX66_RS03300	COG2130	NADP-dependent
MICNX66_RS03310	COG0017	Asparaginyl-tRNA synthetase
MICNX66_RS03320	COG1253	flavin adenine dinucleotide binding
MICNX66_RS03325	COG0010	Belongs to the arginase family
MICNX66_RS03340	COG2197	response regulator
MICNX66_RS03345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MICNX66_RS03395	COG1690	Belongs to the RtcB family
MICNX66_RS03410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MICNX66_RS03465	COG0419	ATPase involved in DNA repair
MICNX66_RS03490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MICNX66_RS03495	COG0037	tRNA processing
MICNX66_RS03495	COG0590	tRNA wobble adenosine to inosine editing
MICNX66_RS03520	COG0569	domain protein
MICNX66_RS03525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MICNX66_RS03530	COG0640	Transcriptional regulator
MICNX66_RS03550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MICNX66_RS03570	COG0765	amino acid transport
MICNX66_RS03575	COG1126	abc transporter atp-binding protein
MICNX66_RS03580	COG3842	ATPase activity
MICNX66_RS03610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MICNX66_RS03620	COG0406	alpha-ribazole phosphatase activity
MICNX66_RS03625	COG0492	ferredoxin-NADP+ reductase activity
MICNX66_RS03640	COG0785	Cytochrome C biogenesis protein
MICNX66_RS03650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MICNX66_RS03665	COG2409	Drug exporters of the RND superfamily
MICNX66_RS03670	COG1309	transcriptional regulator
MICNX66_RS03675	COG4948	Mandelate Racemase Muconate Lactonizing
MICNX66_RS03695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MICNX66_RS03710	COG4585	Histidine kinase
MICNX66_RS03715	COG2197	response regulator
MICNX66_RS03720	COG0577	efflux transmembrane transporter activity
MICNX66_RS03720	COG1136	(ABC) transporter
MICNX66_RS03730	COG2045	Belongs to the ComB family
MICNX66_RS03755	COG1316	TRANSCRIPTIONal
MICNX66_RS03770	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS03775	COG1472	Belongs to the glycosyl hydrolase 3 family
MICNX66_RS03780	COG1737	Transcriptional regulator
MICNX66_RS03790	COG0747	negative chemotaxis
MICNX66_RS03795	COG0601	transmembrane transport
MICNX66_RS03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS03810	COG0085	RNA polymerase activity
MICNX66_RS03815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MICNX66_RS03850	COG0739	heme binding
MICNX66_RS03920	COG1595	DNA-templated transcription, initiation
MICNX66_RS03935	COG0702	epimerase
MICNX66_RS03940	COG1733	regulation of RNA biosynthetic process
MICNX66_RS03950	COG0101	tRNA pseudouridine synthase activity
MICNX66_RS03960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MICNX66_RS03965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MICNX66_RS03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MICNX66_RS03990	COG0489	protein tyrosine kinase activity
MICNX66_RS03995	COG1072	(Pantothenic acid kinase))
MICNX66_RS04000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MICNX66_RS04005	COG0736	holo-[acyl-carrier-protein] synthase activity
MICNX66_RS04010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MICNX66_RS04015	COG0802	atpase or kinase
MICNX66_RS04020	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS04025	COG5002	protein histidine kinase activity
MICNX66_RS04040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MICNX66_RS04045	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MICNX66_RS04050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MICNX66_RS04055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MICNX66_RS04070	COG1338	Plays a role in the flagellum-specific transport system
MICNX66_RS04105	COG0739	heme binding
MICNX66_RS04115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MICNX66_RS04130	COG1157	protein secretion by the type III secretion system
MICNX66_RS04140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MICNX66_RS04145	COG1766	The M ring may be actively involved in energy transduction
MICNX66_RS04150	COG1677	Flagellar hook-basal body complex protein FliE
MICNX66_RS04160	COG1815	bacterial-type flagellum-dependent cell motility
MICNX66_RS04180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MICNX66_RS04200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MICNX66_RS04210	COG0456	acetyltransferase
MICNX66_RS04210	COG1214	PFAM Peptidase M22, glycoprotease
MICNX66_RS04220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MICNX66_RS04245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MICNX66_RS04295	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS04305	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MICNX66_RS04310	COG1215	transferase activity, transferring glycosyl groups
MICNX66_RS04320	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS04325	COG2205	protein histidine kinase activity
MICNX66_RS04335	COG0488	(ABC) transporter
MICNX66_RS04340	COG0516	GMP reductase activity
MICNX66_RS04350	COG0737	Belongs to the 5'-nucleotidase family
MICNX66_RS04350	COG1525	nuclease
MICNX66_RS04350	COG4085	toxin activity
MICNX66_RS04360	COG0519	Catalyzes the synthesis of GMP from XMP
MICNX66_RS04360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MICNX66_RS04370	COG1649	PFAM Uncharacterised BCR, COG1649
MICNX66_RS04380	COG4941	Belongs to the sigma-70 factor family
MICNX66_RS04385	COG2261	transglycosylase associated protein
MICNX66_RS04395	COG0584	glycerophosphoryl diester phosphodiesterase
MICNX66_RS04400	COG3304	Inner membrane component domain
MICNX66_RS04435	COG1793	dna ligase
MICNX66_RS04450	COG0456	acetyltransferase
MICNX66_RS04450	COG0454	-acetyltransferase
MICNX66_RS04460	COG1309	transcriptional regulator
MICNX66_RS04470	COG0045	succinate-CoA ligase (ADP-forming) activity
MICNX66_RS04480	COG2252	PERMEase
MICNX66_RS04495	COG0138	bifunctional purine biosynthesis protein purh
MICNX66_RS04505	COG2169	Transcriptional regulator
MICNX66_RS04505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MICNX66_RS04515	COG1132	(ABC) transporter
MICNX66_RS04530	COG2838	Isocitrate dehydrogenase
MICNX66_RS04560	COG1940	carbohydrate kinase activity
MICNX66_RS04565	COG0363	glucosamine-6-phosphate deaminase activity
MICNX66_RS04575	COG0277	FAD linked oxidase domain protein
MICNX66_RS04600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MICNX66_RS04605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MICNX66_RS04625	COG3971	2-oxopent-4-enoate hydratase activity
MICNX66_RS04635	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS04640	COG1802	Transcriptional regulator
MICNX66_RS04650	COG0477	Major facilitator Superfamily
MICNX66_RS04655	COG1414	Transcriptional regulator
MICNX66_RS04670	COG0384	phenazine biosynthesis protein PhzF
MICNX66_RS04680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MICNX66_RS04685	COG1793	dna ligase
MICNX66_RS04695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MICNX66_RS04700	COG2151	metal-sulfur cluster biosynthetic enzyme
MICNX66_RS04705	COG3396	Phenylacetate-CoA oxygenase
MICNX66_RS04710	COG3460	Phenylacetate-CoA oxygenase
MICNX66_RS04715	COG3396	Phenylacetate-CoA oxygenase
MICNX66_RS04725	COG0514	ATP-dependent DNA helicase (RecQ)
MICNX66_RS04735	COG2376	Dihydroxyacetone kinase
MICNX66_RS04740	COG1461	Dihydroxyacetone kinase
MICNX66_RS04745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MICNX66_RS04750	COG2050	protein possibly involved in aromatic compounds catabolism
MICNX66_RS04760	COG1309	transcriptional regulator
MICNX66_RS04765	COG2030	dehydratase
MICNX66_RS04765	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS04770	COG1250	3-hydroxyacyl-CoA dehydrogenase
MICNX66_RS04775	COG1024	Enoyl-CoA hydratase
MICNX66_RS04785	COG0477	Major facilitator Superfamily
MICNX66_RS04790	COG0508	dehydrogenase complex catalyzes the overall conversion of
MICNX66_RS04795	COG0022	dehydrogenase e1 component
MICNX66_RS04815	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS04830	COG2149	membrane
MICNX66_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS04860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MICNX66_RS04905	COG1737	Transcriptional regulator
MICNX66_RS04915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MICNX66_RS04930	COG3226	Transcriptional regulator
MICNX66_RS04940	COG2814	Major facilitator Superfamily
MICNX66_RS04955	COG0667	Aldo Keto reductase
MICNX66_RS04960	COG1063	alcohol dehydrogenase
MICNX66_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS04975	COG0747	negative chemotaxis
MICNX66_RS04980	COG0601	transmembrane transport
MICNX66_RS04985	COG0444	Belongs to the ABC transporter superfamily
MICNX66_RS04990	COG4172	Belongs to the ABC transporter superfamily
MICNX66_RS04995	COG1309	transcriptional regulator
MICNX66_RS05030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MICNX66_RS05035	COG1132	(ABC) transporter
MICNX66_RS05050	COG0477	Major facilitator Superfamily
MICNX66_RS05070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MICNX66_RS05075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MICNX66_RS05075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MICNX66_RS05090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MICNX66_RS05110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MICNX66_RS05115	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MICNX66_RS05120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MICNX66_RS05130	COG0124	histidyl-tRNA synthetase
MICNX66_RS05135	COG2755	lipolytic protein G-D-S-L family
MICNX66_RS05175	COG4122	O-methyltransferase activity
MICNX66_RS05180	COG0148	phosphopyruvate hydratase activity
MICNX66_RS05230	COG1704	LemA family
MICNX66_RS05240	COG3214	Protein conserved in bacteria
MICNX66_RS05250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MICNX66_RS05255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MICNX66_RS05275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MICNX66_RS05285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MICNX66_RS05295	COG0114	fumarate hydratase activity
MICNX66_RS05310	COG1722	exodeoxyribonuclease VII activity
MICNX66_RS05315	COG1570	exodeoxyribonuclease VII activity
MICNX66_RS05320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MICNX66_RS05335	COG0191	fructose-bisphosphate aldolase activity
MICNX66_RS05350	COG1322	Protein conserved in bacteria
MICNX66_RS05355	COG2176	DNA-directed DNA polymerase activity
MICNX66_RS05365	COG0012	GTP binding
MICNX66_RS05400	COG3546	catalase activity
MICNX66_RS05425	COG0783	Belongs to the Dps family
MICNX66_RS05455	COG2814	Major facilitator Superfamily
MICNX66_RS05460	COG1132	(ABC) transporter
MICNX66_RS05470	COG1215	transferase activity, transferring glycosyl groups
MICNX66_RS05475	COG1104	cysteine desulfurase activity
MICNX66_RS05485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MICNX66_RS05490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MICNX66_RS05505	COG0601	transmembrane transport
MICNX66_RS05515	COG0444	Belongs to the ABC transporter superfamily
MICNX66_RS05525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MICNX66_RS05530	COG0509	glycine decarboxylation via glycine cleavage system
MICNX66_RS05535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MICNX66_RS05535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MICNX66_RS05540	COG4166	transmembrane transport
MICNX66_RS05545	COG0601	transmembrane transport
MICNX66_RS05550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS05555	COG4172	Belongs to the ABC transporter superfamily
MICNX66_RS05570	COG1217	gtp-binding protein TYPA
MICNX66_RS05580	COG2066	Belongs to the glutaminase family
MICNX66_RS05630	COG2171	N-acyltransferase activity
MICNX66_RS05635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MICNX66_RS05655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MICNX66_RS05675	COG2239	Acts as a magnesium transporter
MICNX66_RS05690	COG0006	proline dipeptidase activity
MICNX66_RS05710	COG0513	Belongs to the DEAD box helicase family
MICNX66_RS05735	COG0210	DNA helicase
MICNX66_RS05760	COG3480	Lon protease (S16) C-terminal proteolytic domain
MICNX66_RS05765	COG1615	UPF0182 protein
MICNX66_RS05785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MICNX66_RS05795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MICNX66_RS05800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MICNX66_RS05805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MICNX66_RS05870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MICNX66_RS05875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MICNX66_RS05880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MICNX66_RS05885	COG2089	acid synthase
MICNX66_RS05900	COG1083	cytidylyl-transferase
MICNX66_RS05940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MICNX66_RS05960	COG1132	(ABC) transporter
MICNX66_RS05975	COG1215	transferase activity, transferring glycosyl groups
MICNX66_RS05980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MICNX66_RS06005	COG1216	Glycosyl transferase, family 2
MICNX66_RS06010	COG1216	Glycosyl transferase, family 2
MICNX66_RS06030	COG1482	cell wall glycoprotein biosynthetic process
MICNX66_RS06075	COG0714	Associated with various cellular activities
MICNX66_RS06095	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS06100	COG5000	phosphorelay sensor kinase activity
MICNX66_RS06100	COG5002	protein histidine kinase activity
MICNX66_RS06105	COG5401	PFAM Sporulation and spore germination
MICNX66_RS06130	COG0653	protein targeting
MICNX66_RS06190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MICNX66_RS06195	COG1595	DNA-templated transcription, initiation
MICNX66_RS06205	COG4552	Acetyltransferase involved in intracellular survival and related
MICNX66_RS06210	COG0567	Dehydrogenase, E1 component
MICNX66_RS06210	COG0508	dehydrogenase complex catalyzes the overall conversion of
MICNX66_RS06215	COG0516	GMP reductase activity
MICNX66_RS06215	COG0517	IMP dehydrogenase activity
MICNX66_RS06220	COG1253	flavin adenine dinucleotide binding
MICNX66_RS06230	COG1902	pentaerythritol trinitrate reductase activity
MICNX66_RS06250	COG2814	Major facilitator Superfamily
MICNX66_RS06260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MICNX66_RS06275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MICNX66_RS06290	COG0444	Belongs to the ABC transporter superfamily
MICNX66_RS06295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS06305	COG0747	negative chemotaxis
MICNX66_RS06310	COG0596	Alpha beta hydrolase
MICNX66_RS06310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MICNX66_RS06315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MICNX66_RS06340	COG1842	Phage shock protein A
MICNX66_RS06355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MICNX66_RS06415	COG0628	permease
MICNX66_RS06450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MICNX66_RS06485	COG1063	alcohol dehydrogenase
MICNX66_RS06490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MICNX66_RS06525	COG0018	arginyl-trna synthetase
MICNX66_RS06560	COG0460	homoserine dehydrogenase
MICNX66_RS06565	COG0083	homoserine kinase activity
MICNX66_RS06575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MICNX66_RS06580	COG4565	transcriptional regulatory protein
MICNX66_RS06585	COG3290	protein histidine kinase activity
MICNX66_RS06590	COG2851	Citrate transporter
MICNX66_RS06595	COG1045	serine acetyltransferase
MICNX66_RS06605	COG2890	protein-(glutamine-N5) methyltransferase activity
MICNX66_RS06615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MICNX66_RS06625	COG0356	it plays a direct role in the translocation of protons across the membrane
MICNX66_RS06630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MICNX66_RS06635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MICNX66_RS06640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MICNX66_RS06645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MICNX66_RS06650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MICNX66_RS06655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MICNX66_RS06660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MICNX66_RS06665	COG3022	response to hydroperoxide
MICNX66_RS06675	COG0631	protein serine/threonine phosphatase activity
MICNX66_RS06680	COG1674	ftsk spoiiie
MICNX66_RS06705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MICNX66_RS06710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MICNX66_RS06725	COG0750	zinc metalloprotease
MICNX66_RS06735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MICNX66_RS06755	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MICNX66_RS06765	COG0442	prolyl-tRNA aminoacylation
MICNX66_RS06775	COG1611	Belongs to the LOG family
MICNX66_RS06790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MICNX66_RS06795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MICNX66_RS06800	COG2197	response regulator
MICNX66_RS06805	COG1194	a g-specific adenine glycosylase
MICNX66_RS06810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MICNX66_RS06825	COG0196	riboflavin kinase activity
MICNX66_RS06830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MICNX66_RS06870	COG0179	Fumarylacetoacetate (FAA) hydrolase
MICNX66_RS06880	COG0545	Peptidyl-prolyl cis-trans isomerase
MICNX66_RS06895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MICNX66_RS06920	COG2822	iron ion transport
MICNX66_RS06925	COG2837	iron assimilation
MICNX66_RS06935	COG3594	Acyltransferase
MICNX66_RS06960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MICNX66_RS06960	COG0438	transferase activity, transferring glycosyl groups
MICNX66_RS06965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MICNX66_RS06970	COG1185	polyribonucleotide nucleotidyltransferase activity
MICNX66_RS06975	COG0667	Aldo Keto reductase
MICNX66_RS06995	COG1764	response to oxidative stress
MICNX66_RS07010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MICNX66_RS07025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MICNX66_RS07030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MICNX66_RS07035	COG1674	ftsk spoiiie
MICNX66_RS07040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MICNX66_RS07045	COG1058	Belongs to the CinA family
MICNX66_RS07045	COG1546	Belongs to the CinA family
MICNX66_RS07050	COG1396	sequence-specific DNA binding
MICNX66_RS07060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MICNX66_RS07065	COG2137	regulation of response to DNA damage stimulus
MICNX66_RS07070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MICNX66_RS07075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MICNX66_RS07085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MICNX66_RS07095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MICNX66_RS07130	COG0483	inositol monophosphate 1-phosphatase activity
MICNX66_RS07160	COG0442	prolyl-tRNA aminoacylation
MICNX66_RS07165	COG2814	Major facilitator Superfamily
MICNX66_RS07205	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MICNX66_RS07215	COG0129	dihydroxy-acid dehydratase activity
MICNX66_RS07230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MICNX66_RS07240	COG1940	carbohydrate kinase activity
MICNX66_RS07245	COG2182	Extracellular solute-binding protein
MICNX66_RS07250	COG1175	transmembrane transport
MICNX66_RS07255	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS07260	COG1940	carbohydrate kinase activity
MICNX66_RS07275	COG0277	FAD linked oxidase domain protein
MICNX66_RS07305	COG1309	transcriptional regulator
MICNX66_RS07310	COG0477	Major facilitator Superfamily
MICNX66_RS07315	COG0473	3-isopropylmalate dehydrogenase activity
MICNX66_RS07320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MICNX66_RS07330	COG0179	Fumarylacetoacetate (FAA) hydrolase
MICNX66_RS07335	COG2814	Major facilitator Superfamily
MICNX66_RS07345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MICNX66_RS07365	COG2814	Major facilitator Superfamily
MICNX66_RS07430	COG2873	o-acetylhomoserine
MICNX66_RS07435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MICNX66_RS07440	COG0066	3-isopropylmalate dehydratase activity
MICNX66_RS07445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MICNX66_RS07455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MICNX66_RS07460	COG1181	Belongs to the D-alanine--D-alanine ligase family
MICNX66_RS07475	COG0742	ribosomal rna small subunit methyltransferase
MICNX66_RS07485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MICNX66_RS07495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MICNX66_RS07500	COG0571	ribonuclease III activity
MICNX66_RS07505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MICNX66_RS07515	COG1136	(ABC) transporter
MICNX66_RS07530	COG1196	nuclear chromosome segregation
MICNX66_RS07550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MICNX66_RS07555	COG0321	lipoyl(octanoyl) transferase activity
MICNX66_RS07560	COG1309	transcriptional regulator
MICNX66_RS07580	COG0697	spore germination
MICNX66_RS07585	COG0583	DNA-binding transcription factor activity
MICNX66_RS07590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MICNX66_RS07595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MICNX66_RS07600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MICNX66_RS07610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MICNX66_RS07615	COG0228	four-way junction DNA binding
MICNX66_RS07620	COG1837	Belongs to the UPF0109 family
MICNX66_RS07625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MICNX66_RS07630	COG0336	Belongs to the RNA methyltransferase TrmD family
MICNX66_RS07655	COG0335	large ribosomal subunit rRNA binding
MICNX66_RS07660	COG0681	Belongs to the peptidase S26 family
MICNX66_RS07665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MICNX66_RS07675	COG0792	nuclease activity
MICNX66_RS07700	COG0052	Belongs to the universal ribosomal protein uS2 family
MICNX66_RS07705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MICNX66_RS07710	COG0528	UMP kinase activity
MICNX66_RS07715	COG0233	cytoplasmic translational termination
MICNX66_RS07750	COG3118	belongs to the thioredoxin family
MICNX66_RS07755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MICNX66_RS07760	COG0366	Alpha amylase catalytic
MICNX66_RS07775	COG0482	sulfurtransferase activity
MICNX66_RS07780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MICNX66_RS07785	COG0456	acetyltransferase
MICNX66_RS07795	COG0318	PFAM AMP-dependent synthetase and ligase
MICNX66_RS07800	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MICNX66_RS07805	COG0154	amidase activity
MICNX66_RS07810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MICNX66_RS07815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MICNX66_RS07835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MICNX66_RS07845	COG1280	lysine exporter protein (LysE YggA)
MICNX66_RS07855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MICNX66_RS07870	COG0629	single-stranded DNA binding
MICNX66_RS07890	COG1946	Acyl-CoA thioesterase
MICNX66_RS07910	COG0668	transmembrane transport
MICNX66_RS07920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MICNX66_RS07945	COG0783	Belongs to the Dps family
MICNX66_RS07965	COG1388	LysM domain
MICNX66_RS07965	COG4932	domain protein
MICNX66_RS08010	COG0022	dehydrogenase e1 component
MICNX66_RS08015	COG0508	dehydrogenase complex catalyzes the overall conversion of
MICNX66_RS08025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MICNX66_RS08035	COG1960	acyl-CoA dehydrogenase activity
MICNX66_RS08050	COG0406	alpha-ribazole phosphatase activity
MICNX66_RS08065	COG2755	lipolytic protein G-D-S-L family
MICNX66_RS08085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MICNX66_RS08090	COG1968	undecaprenyl-diphosphatase activity
MICNX66_RS08100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MICNX66_RS08125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MICNX66_RS08130	COG0805	protein transport
MICNX66_RS08135	COG4581	dead DEAH box helicase
MICNX66_RS08150	COG0584	glycerophosphoryl diester phosphodiesterase
MICNX66_RS08185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MICNX66_RS08205	COG0542	response to heat
MICNX66_RS08260	COG0477	Major facilitator Superfamily
MICNX66_RS08265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MICNX66_RS08320	COG0069	glutamate synthase activity
MICNX66_RS08320	COG0070	glutamate synthase
MICNX66_RS08320	COG0067	glutamate synthase
MICNX66_RS08325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MICNX66_RS08330	COG0159	tryptophan synthase activity
MICNX66_RS08335	COG0133	tryptophan synthase activity
MICNX66_RS08340	COG0134	indole-3-glycerol-phosphate synthase activity
MICNX66_RS08355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MICNX66_RS08360	COG0107	imidazoleglycerol-phosphate synthase activity
MICNX66_RS08365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MICNX66_RS08370	COG0140	phosphoribosyl-ATP diphosphatase activity
MICNX66_RS08375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MICNX66_RS08385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MICNX66_RS08390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MICNX66_RS08395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MICNX66_RS08400	COG1758	RNA polymerase activity
MICNX66_RS08405	COG0194	GDP metabolic process
MICNX66_RS08410	COG0284	orotidine-5'-phosphate decarboxylase activity
MICNX66_RS08415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MICNX66_RS08420	COG0505	Belongs to the CarA family
MICNX66_RS08430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MICNX66_RS08435	COG0540	Belongs to the ATCase OTCase family
MICNX66_RS08440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MICNX66_RS08445	COG2146	nitrite reductase [NAD(P)H] activity
MICNX66_RS08445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MICNX66_RS08450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MICNX66_RS08455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MICNX66_RS08460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MICNX66_RS08470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MICNX66_RS08480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MICNX66_RS08485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MICNX66_RS08490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MICNX66_RS08495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MICNX66_RS08505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MICNX66_RS08510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MICNX66_RS08520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MICNX66_RS08540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MICNX66_RS08555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MICNX66_RS08560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MICNX66_RS08565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MICNX66_RS08575	COG2255	four-way junction helicase activity
MICNX66_RS08580	COG0632	four-way junction helicase activity
MICNX66_RS08585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MICNX66_RS08590	COG0217	transcriptional regulatory protein
MICNX66_RS08595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MICNX66_RS08600	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MICNX66_RS08610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MICNX66_RS08620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MICNX66_RS08625	COG1742	UPF0060 membrane protein
MICNX66_RS08635	COG0415	Belongs to the DNA photolyase family
MICNX66_RS08650	COG2847	Copper chaperone PCu(A)C
MICNX66_RS08655	COG2837	iron assimilation
MICNX66_RS08660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MICNX66_RS08700	COG0366	Alpha amylase catalytic
MICNX66_RS08705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MICNX66_RS08735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MICNX66_RS08765	COG0183	Belongs to the thiolase family
MICNX66_RS08770	COG1024	Enoyl-CoA hydratase
MICNX66_RS08770	COG1250	3-hydroxyacyl-CoA dehydrogenase
MICNX66_RS08785	COG0277	FAD linked oxidase domain protein
MICNX66_RS08800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MICNX66_RS08805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MICNX66_RS08820	COG0756	dUTP diphosphatase activity
MICNX66_RS08845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MICNX66_RS08850	COG0187	DNA topoisomerase II activity
MICNX66_RS08860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MICNX66_RS08880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MICNX66_RS08890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MICNX66_RS08895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MICNX66_RS08900	COG0508	dehydrogenase complex catalyzes the overall conversion of
MICNX66_RS08915	COG0189	ligase activity
MICNX66_RS08915	COG0569	domain protein
MICNX66_RS08920	COG0189	ligase activity
MICNX66_RS08920	COG4067	protein conserved in archaea
MICNX66_RS08930	COG0174	glutamine synthetase
MICNX66_RS08965	COG0346	lactoylglutathione lyase activity
MICNX66_RS08970	COG0515	serine threonine protein kinase
MICNX66_RS08975	COG0628	permease
MICNX66_RS08980	COG1597	lipid kinase activity
MICNX66_RS08985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MICNX66_RS08990	COG0174	glutamine synthetase
MICNX66_RS09020	COG3012	SEC-C Motif Domain Protein
MICNX66_RS09035	COG4221	oxidoreductase activity
MICNX66_RS09040	COG0039	L-malate dehydrogenase activity
MICNX66_RS09055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MICNX66_RS09070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MICNX66_RS09075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MICNX66_RS09080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MICNX66_RS09085	COG2364	Membrane
MICNX66_RS09090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MICNX66_RS09120	COG0254	rRNA binding
MICNX66_RS09125	COG1119	ATPase activity
MICNX66_RS09130	COG0297	glycogen (starch) synthase activity
MICNX66_RS09135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MICNX66_RS09140	COG0560	Phosphoserine phosphatase
MICNX66_RS09140	COG3830	Belongs to the UPF0237 family
MICNX66_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS09180	COG0259	pyridoxamine-phosphate oxidase activity
MICNX66_RS09185	COG0488	(ABC) transporter
MICNX66_RS09190	COG0586	Pfam SNARE associated Golgi protein
MICNX66_RS09195	COG4585	Histidine kinase
MICNX66_RS09200	COG2197	response regulator
MICNX66_RS09210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MICNX66_RS09215	COG1122	ATPase activity
MICNX66_RS09230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MICNX66_RS09235	COG2151	metal-sulfur cluster biosynthetic enzyme
MICNX66_RS09240	COG0396	ATPase activity
MICNX66_RS09260	COG1612	heme a metabolic process
MICNX66_RS09270	COG0109	protoheme IX farnesyltransferase activity
MICNX66_RS09280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MICNX66_RS09285	COG0166	Belongs to the GPI family
MICNX66_RS09300	COG0363	glucosamine-6-phosphate deaminase activity
MICNX66_RS09325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MICNX66_RS09345	COG0358	DNA primase activity
MICNX66_RS09360	COG0386	Belongs to the glutathione peroxidase family
MICNX66_RS09380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MICNX66_RS09385	COG1381	Involved in DNA repair and RecF pathway recombination
MICNX66_RS09405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MICNX66_RS09415	COG0604	alcohol dehydrogenase
MICNX66_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS09415	COG3321	synthase
MICNX66_RS09440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MICNX66_RS09450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MICNX66_RS09460	COG0537	adenosine 5'-monophosphoramidase activity
MICNX66_RS09470	COG0484	heat shock protein binding
MICNX66_RS09475	COG1420	regulation of RNA biosynthetic process
MICNX66_RS09490	COG2827	Endonuclease containing a URI domain
MICNX66_RS09495	COG0481	GTPase activity
MICNX66_RS09535	COG0268	Binds directly to 16S ribosomal RNA
MICNX66_RS09560	COG1555	photosystem II stabilization
MICNX66_RS09560	COG1596	polysaccharide export
MICNX66_RS09565	COG0495	leucyl-tRNA aminoacylation
MICNX66_RS09570	COG0512	Glutamine amidotransferase of anthranilate synthase
MICNX66_RS09570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MICNX66_RS09590	COG1472	Belongs to the glycosyl hydrolase 3 family
MICNX66_RS09620	COG2755	lipolytic protein G-D-S-L family
MICNX66_RS09620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MICNX66_RS09650	COG4221	oxidoreductase activity
MICNX66_RS09655	COG0799	negative regulation of ribosome biogenesis
MICNX66_RS09665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MICNX66_RS09675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MICNX66_RS09680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MICNX66_RS09685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MICNX66_RS09690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MICNX66_RS09695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MICNX66_RS09705	COG1530	ribonuclease E activity
MICNX66_RS09715	COG0105	UTP biosynthetic process
MICNX66_RS09725	COG0285	dihydrofolate synthase activity
MICNX66_RS09730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MICNX66_RS09745	COG4172	Belongs to the ABC transporter superfamily
MICNX66_RS09750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS09760	COG0747	negative chemotaxis
MICNX66_RS09770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MICNX66_RS09770	COG0519	Catalyzes the synthesis of GMP from XMP
MICNX66_RS09785	COG4948	Mandelate Racemase Muconate Lactonizing
MICNX66_RS09805	COG0747	negative chemotaxis
MICNX66_RS09810	COG0601	transmembrane transport
MICNX66_RS09815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS09825	COG1619	proteins homologs of microcin C7 resistance protein MccF
MICNX66_RS09845	COG0525	valine-tRNA ligase activity
MICNX66_RS09865	COG0156	8-amino-7-oxononanoate synthase activity
MICNX66_RS09870	COG1063	alcohol dehydrogenase
MICNX66_RS09880	COG0339	signal peptide processing
MICNX66_RS09890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MICNX66_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS09910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MICNX66_RS09920	COG0740	serine-type endopeptidase activity
MICNX66_RS09925	COG0740	serine-type endopeptidase activity
MICNX66_RS09935	COG0544	peptidyl-prolyl cis-trans isomerase activity
MICNX66_RS09960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MICNX66_RS09965	COG0149	triose-phosphate isomerase activity
MICNX66_RS09970	COG0126	phosphoglycerate kinase activity
MICNX66_RS09975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MICNX66_RS09980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MICNX66_RS09985	COG1481	regulation of sporulation
MICNX66_RS09990	COG1660	Displays ATPase and GTPase activities
MICNX66_RS09995	COG0322	excinuclease ABC activity
MICNX66_RS10015	COG0714	Associated with various cellular activities
MICNX66_RS10030	COG1846	Transcriptional regulator
MICNX66_RS10045	COG0556	nucleotide-excision repair
MICNX66_RS10050	COG0237	dephospho-CoA kinase activity
MICNX66_RS10070	COG1832	CoA-binding protein
MICNX66_RS10075	COG2873	o-acetylhomoserine
MICNX66_RS10080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MICNX66_RS10085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MICNX66_RS10090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MICNX66_RS10095	COG1116	anion transmembrane transporter activity
MICNX66_RS10115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MICNX66_RS10120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MICNX66_RS10120	COG1796	DNA polymerase
MICNX66_RS10125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MICNX66_RS10130	COG1845	cytochrome c oxidase, subunit III
MICNX66_RS10135	COG2010	Cytochrome c
MICNX66_RS10140	COG0723	plastoquinol--plastocyanin reductase activity
MICNX66_RS10145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MICNX66_RS10170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MICNX66_RS10175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MICNX66_RS10195	COG0167	dihydroorotate dehydrogenase activity
MICNX66_RS10200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MICNX66_RS10205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MICNX66_RS10215	COG0587	DNA-directed DNA polymerase activity
MICNX66_RS10230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MICNX66_RS10235	COG3599	regulation of cell shape
MICNX66_RS10245	COG1799	cell septum assembly
MICNX66_RS10255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MICNX66_RS10265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MICNX66_RS10270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MICNX66_RS10280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MICNX66_RS10285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MICNX66_RS10290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MICNX66_RS10295	COG0768	penicillin binding
MICNX66_RS10305	COG0275	rRNA processing
MICNX66_RS10310	COG2001	Belongs to the MraZ family
MICNX66_RS10320	COG0142	geranyltranstransferase activity
MICNX66_RS10330	COG1705	Flagellar rod assembly protein muramidase FlgJ
MICNX66_RS10330	COG1388	LysM domain
MICNX66_RS10335	COG2815	serine threonine protein kinase
MICNX66_RS10335	COG0515	serine threonine protein kinase
MICNX66_RS10340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MICNX66_RS10345	COG0204	Acyl-transferase
MICNX66_RS10350	COG1022	Amp-dependent synthetase and ligase
MICNX66_RS10365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MICNX66_RS10370	COG1192	Involved in chromosome partitioning
MICNX66_RS10385	COG1716	ATPase activity
MICNX66_RS10390	COG2372	response to copper ion
MICNX66_RS10410	COG3424	synthase
MICNX66_RS10440	COG0587	DNA-directed DNA polymerase activity
MICNX66_RS10465	COG3973	AAA domain
MICNX66_RS10480	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS10510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MICNX66_RS10520	COG0154	amidase activity
MICNX66_RS10525	COG2957	Belongs to the agmatine deiminase family
MICNX66_RS10570	COG1160	GTP binding
MICNX66_RS10575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MICNX66_RS10590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MICNX66_RS10610	COG0494	nUDIX hydrolase
MICNX66_RS10615	COG0504	CTP synthase activity
MICNX66_RS10620	COG0497	DNA recombination
MICNX66_RS10625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MICNX66_RS10640	COG0647	UMP catabolic process
MICNX66_RS10665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MICNX66_RS10675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MICNX66_RS10695	COG0165	Argininosuccinate lyase
MICNX66_RS10700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MICNX66_RS10705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MICNX66_RS10710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MICNX66_RS10715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MICNX66_RS10720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MICNX66_RS10725	COG0352	thiamine-phosphate diphosphorylase activity
MICNX66_RS10725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MICNX66_RS10725	COG0351	phosphomethylpyrimidine kinase
MICNX66_RS10730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MICNX66_RS10745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MICNX66_RS10745	COG0072	phenylalanine-tRNA ligase activity
MICNX66_RS10750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MICNX66_RS10755	COG0765	amino acid transport
MICNX66_RS10760	COG0765	amino acid transport
MICNX66_RS10765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MICNX66_RS10770	COG1126	abc transporter atp-binding protein
MICNX66_RS10775	COG2358	TRAP transporter, solute receptor (TAXI family
MICNX66_RS10780	COG5002	protein histidine kinase activity
MICNX66_RS10790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MICNX66_RS10795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MICNX66_RS10800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MICNX66_RS10805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MICNX66_RS10820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MICNX66_RS10825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MICNX66_RS10830	COG0131	Imidazoleglycerol-phosphate dehydratase
MICNX66_RS10835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MICNX66_RS10845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MICNX66_RS10850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MICNX66_RS10855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MICNX66_RS10865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MICNX66_RS10870	COG2177	Part of the ABC transporter FtsEX involved in
MICNX66_RS10875	COG2884	Cell division ATP-binding protein ftsE
MICNX66_RS10885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MICNX66_RS10985	COG0586	Pfam SNARE associated Golgi protein
MICNX66_RS10990	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MICNX66_RS11005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MICNX66_RS11010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MICNX66_RS11015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MICNX66_RS11020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MICNX66_RS11040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MICNX66_RS11050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MICNX66_RS11070	COG2197	response regulator
MICNX66_RS11075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MICNX66_RS11080	COG0424	maF-like protein
MICNX66_RS11085	COG4770	biotin carboxylase activity
MICNX66_RS11100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MICNX66_RS11125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MICNX66_RS11130	COG2213	PTS system mannitol-specific
MICNX66_RS11135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MICNX66_RS11140	COG0246	Mannitol dehydrogenase
MICNX66_RS11155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MICNX66_RS11170	COG1079	Belongs to the binding-protein-dependent transport system permease family
MICNX66_RS11175	COG4603	Belongs to the binding-protein-dependent transport system permease family
MICNX66_RS11180	COG3845	ABC transporter
MICNX66_RS11185	COG1744	ABC transporter substrate-binding protein PnrA-like
MICNX66_RS11190	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MICNX66_RS11190	COG0662	Cupin 2, conserved barrel domain protein
MICNX66_RS11195	COG2009	succinate dehydrogenase
MICNX66_RS11230	COG0180	Tryptophanyl-tRNA synthetase
MICNX66_RS11240	COG0193	aminoacyl-tRNA hydrolase activity
MICNX66_RS11245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MICNX66_RS11250	COG3265	gluconokinase activity
MICNX66_RS11255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MICNX66_RS11260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MICNX66_RS11270	COG1136	(ABC) transporter
MICNX66_RS11270	COG0577	efflux transmembrane transporter activity
MICNX66_RS11280	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS11285	COG2205	protein histidine kinase activity
MICNX66_RS11290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MICNX66_RS11290	COG1017	nitric oxide dioxygenase activity
MICNX66_RS11295	COG1477	protein flavinylation
MICNX66_RS11305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MICNX66_RS11310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MICNX66_RS11320	COG0454	-acetyltransferase
MICNX66_RS11330	COG1959	2 iron, 2 sulfur cluster binding
MICNX66_RS11340	COG0564	pseudouridine synthase activity
MICNX66_RS11350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MICNX66_RS11370	COG0488	(ABC) transporter
MICNX66_RS11395	COG4214	carbohydrate transport
MICNX66_RS11410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MICNX66_RS11440	COG4608	Belongs to the ABC transporter superfamily
MICNX66_RS11460	COG4948	Mandelate Racemase Muconate Lactonizing
MICNX66_RS11475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MICNX66_RS11480	COG0667	Aldo Keto reductase
MICNX66_RS11485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MICNX66_RS11495	COG0084	hydrolase, TatD family'
MICNX66_RS11500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MICNX66_RS11505	COG2723	6-phospho-beta-galactosidase activity
MICNX66_RS11515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS11520	COG0601	transmembrane transport
MICNX66_RS11555	COG1113	amino acid transport
MICNX66_RS11560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MICNX66_RS11565	COG1331	Highly conserved protein containing a thioredoxin domain
MICNX66_RS11585	COG1643	Atp-dependent helicase
MICNX66_RS11605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MICNX66_RS11610	COG4172	Belongs to the ABC transporter superfamily
MICNX66_RS11615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS11620	COG0601	transmembrane transport
MICNX66_RS11625	COG0747	negative chemotaxis
MICNX66_RS11630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MICNX66_RS11665	COG1172	Belongs to the binding-protein-dependent transport system permease family
MICNX66_RS11670	COG1129	ABC transporter
MICNX66_RS11705	COG1090	epimerase
MICNX66_RS11710	COG0789	Transcriptional regulator
MICNX66_RS11730	COG4989	oxidoreductase activity
MICNX66_RS11780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MICNX66_RS11810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MICNX66_RS11815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MICNX66_RS11840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MICNX66_RS11845	COG0142	geranyltranstransferase activity
MICNX66_RS11870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MICNX66_RS11875	COG2409	Drug exporters of the RND superfamily
MICNX66_RS11900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MICNX66_RS11910	COG1278	Cold shock
MICNX66_RS11925	COG1061	Type III restriction enzyme res subunit
MICNX66_RS11935	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS11940	COG2205	protein histidine kinase activity
MICNX66_RS11950	COG0459	protein refolding
MICNX66_RS11970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MICNX66_RS11985	COG1131	(ABC) transporter
MICNX66_RS11995	COG4585	Histidine kinase
MICNX66_RS12000	COG2197	response regulator
MICNX66_RS12025	COG3842	ATPase activity
MICNX66_RS12035	COG2910	NAD(P)H-binding
MICNX66_RS12040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MICNX66_RS12045	COG0215	cysteine-tRNA ligase activity
MICNX66_RS12050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MICNX66_RS12050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MICNX66_RS12070	COG5002	protein histidine kinase activity
MICNX66_RS12080	COG0588	phosphoglycerate mutase activity
MICNX66_RS12095	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MICNX66_RS12105	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS12110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MICNX66_RS12135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MICNX66_RS12185	COG0693	protein deglycase activity
MICNX66_RS12205	COG1335	isochorismatase
MICNX66_RS12220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MICNX66_RS12225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MICNX66_RS12230	COG1754	DNA topoisomerase type I activity
MICNX66_RS12230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MICNX66_RS12280	COG2801	Transposase and inactivated derivatives
MICNX66_RS12305	COG1250	3-hydroxyacyl-CoA dehydrogenase
MICNX66_RS12310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MICNX66_RS12350	COG2826	transposase and inactivated derivatives, IS30 family
MICNX66_RS12420	COG3415	Transposase
MICNX66_RS12420	COG2801	Transposase and inactivated derivatives
MICNX66_RS12490	COG0277	FAD linked oxidase domain protein
MICNX66_RS12505	COG2814	Major facilitator Superfamily
MICNX66_RS12510	COG1802	Transcriptional regulator
MICNX66_RS12550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MICNX66_RS12565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MICNX66_RS12600	COG1435	thymidine kinase activity
MICNX66_RS12605	COG0579	oxidoreductase
MICNX66_RS12625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MICNX66_RS12645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MICNX66_RS12675	COG0714	Associated with various cellular activities
MICNX66_RS12690	COG1054	Belongs to the UPF0176 family
MICNX66_RS12705	COG1131	(ABC) transporter
MICNX66_RS12715	COG2226	methyltransferase
MICNX66_RS12725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MICNX66_RS12760	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS12765	COG1175	transmembrane transport
MICNX66_RS12770	COG1653	transport
MICNX66_RS12775	COG1609	Transcriptional regulator
MICNX66_RS12780	COG0222	ribosome binding
MICNX66_RS12785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MICNX66_RS12815	COG1126	abc transporter atp-binding protein
MICNX66_RS12820	COG0765	amino acid transport
MICNX66_RS12825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MICNX66_RS12830	COG0081	regulation of translation
MICNX66_RS12835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MICNX66_RS12865	COG0028	Belongs to the TPP enzyme family
MICNX66_RS12875	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS12915	COG3639	organic phosphonate transmembrane transporter activity
MICNX66_RS12925	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MICNX66_RS12960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MICNX66_RS12970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MICNX66_RS12990	COG1396	sequence-specific DNA binding
MICNX66_RS13000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MICNX66_RS13010	COG1522	sequence-specific DNA binding
MICNX66_RS13015	COG0686	Belongs to the AlaDH PNT family
MICNX66_RS13020	COG0436	Aminotransferase
MICNX66_RS13030	COG2610	gluconate transmembrane transporter activity
MICNX66_RS13035	COG2084	Dehydrogenase
MICNX66_RS13045	COG2188	Transcriptional regulator
MICNX66_RS13050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MICNX66_RS13060	COG2030	dehydratase
MICNX66_RS13065	COG2188	Transcriptional regulator
MICNX66_RS13070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MICNX66_RS13075	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS13080	COG1175	transmembrane transport
MICNX66_RS13085	COG1653	transport
MICNX66_RS13090	COG2222	sugar isomerase
MICNX66_RS13095	COG0730	response to heat
MICNX66_RS13110	COG3181	Tripartite tricarboxylate transporter family receptor
MICNX66_RS13115	COG3290	protein histidine kinase activity
MICNX66_RS13120	COG0203	ribosomal protein L17
MICNX66_RS13125	COG0202	RNA polymerase activity
MICNX66_RS13130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MICNX66_RS13135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MICNX66_RS13145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MICNX66_RS13155	COG0024	Methionine aminopeptidase
MICNX66_RS13160	COG0563	adenylate kinase activity
MICNX66_RS13170	COG0200	Binds to the 23S rRNA
MICNX66_RS13175	COG1841	ribosomal large subunit assembly
MICNX66_RS13180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MICNX66_RS13185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MICNX66_RS13190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MICNX66_RS13195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MICNX66_RS13200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MICNX66_RS13205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MICNX66_RS13210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MICNX66_RS13215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MICNX66_RS13220	COG0255	Belongs to the universal ribosomal protein uL29 family
MICNX66_RS13225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MICNX66_RS13230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MICNX66_RS13235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MICNX66_RS13240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MICNX66_RS13245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MICNX66_RS13250	COG0089	rRNA binding
MICNX66_RS13255	COG0088	Forms part of the polypeptide exit tunnel
MICNX66_RS13260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MICNX66_RS13265	COG0051	transcription antitermination factor activity, RNA binding
MICNX66_RS13275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MICNX66_RS13280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MICNX66_RS13285	COG0049	tRNA binding
MICNX66_RS13290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MICNX66_RS13325	COG3833	ABC-type maltose transport systems, permease component
MICNX66_RS13330	COG1175	transmembrane transport
MICNX66_RS13335	COG2182	Extracellular solute-binding protein
MICNX66_RS13350	COG1666	GTP binding
MICNX66_RS13355	COG0582	viral genome integration into host DNA
MICNX66_RS13480	COG0142	geranyltranstransferase activity
MICNX66_RS13485	COG2226	methyltransferase
MICNX66_RS13495	COG1169	isochorismate synthase
MICNX66_RS13500	COG2326	polyphosphate kinase activity
MICNX66_RS13505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MICNX66_RS13525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MICNX66_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS13595	COG1522	sequence-specific DNA binding
MICNX66_RS13620	COG0228	four-way junction DNA binding
MICNX66_RS13640	COG0488	(ABC) transporter
MICNX66_RS13645	COG1201	RNA secondary structure unwinding
MICNX66_RS13655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MICNX66_RS13665	COG2197	response regulator
MICNX66_RS13700	COG0475	glutathione-regulated potassium exporter activity
MICNX66_RS13720	COG0706	membrane insertase activity
MICNX66_RS13725	COG5006	permease, DMT superfamily
MICNX66_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS13750	COG1546	Belongs to the CinA family
MICNX66_RS13750	COG1058	Belongs to the CinA family
MICNX66_RS13770	COG3639	organic phosphonate transmembrane transporter activity
MICNX66_RS13775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MICNX66_RS13780	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MICNX66_RS13785	COG2188	Transcriptional regulator
MICNX66_RS13790	COG4585	Histidine kinase
MICNX66_RS13805	COG1362	aminopeptidase activity
MICNX66_RS13835	COG3483	tryptophan 2,3-dioxygenase activity
MICNX66_RS13885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MICNX66_RS13910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MICNX66_RS13975	COG1864	DNA RNA non-specific endonuclease
MICNX66_RS13975	COG3591	Belongs to the peptidase S1B family
MICNX66_RS13995	COG0477	Major facilitator Superfamily
MICNX66_RS14005	COG3336	cytochrome c oxidase
MICNX66_RS14045	COG0515	serine threonine protein kinase
MICNX66_RS14075	COG1120	ATPase activity
MICNX66_RS14080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MICNX66_RS14130	COG1295	ribonuclease BN
MICNX66_RS14180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MICNX66_RS14180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MICNX66_RS14195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MICNX66_RS14200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MICNX66_RS14205	COG1780	Probably involved in ribonucleotide reductase function
MICNX66_RS14235	COG1522	sequence-specific DNA binding
MICNX66_RS14250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MICNX66_RS14255	COG1937	Protein conserved in bacteria
MICNX66_RS14260	COG2733	membrane
MICNX66_RS14285	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS14295	COG1228	amidohydrolase
MICNX66_RS14300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MICNX66_RS14305	COG2986	histidine ammonia-lyase
MICNX66_RS14330	COG0477	Major facilitator Superfamily
MICNX66_RS14340	COG1802	Transcriptional regulator
MICNX66_RS14365	COG4988	ABC transporter
MICNX66_RS14370	COG4988	ABC transporter
MICNX66_RS14375	COG1294	oxidase, subunit
MICNX66_RS14380	COG1271	oxidase subunit
MICNX66_RS14390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MICNX66_RS14405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MICNX66_RS14430	COG3655	Transcriptional regulator
MICNX66_RS14440	COG1301	dicarboxylic acid transport
MICNX66_RS14450	COG0789	Transcriptional regulator
MICNX66_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MICNX66_RS14490	COG1116	anion transmembrane transporter activity
MICNX66_RS14500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MICNX66_RS14505	COG1929	Belongs to the glycerate kinase type-1 family
MICNX66_RS14510	COG1609	Transcriptional regulator
MICNX66_RS14530	COG0673	inositol 2-dehydrogenase activity
MICNX66_RS14535	COG1609	Transcriptional regulator
MICNX66_RS14540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MICNX66_RS14550	COG1609	Transcriptional regulator
MICNX66_RS14560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MICNX66_RS14570	COG2211	Major facilitator Superfamily
MICNX66_RS14590	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS14595	COG1522	sequence-specific DNA binding
MICNX66_RS14600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MICNX66_RS14610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MICNX66_RS14615	COG0095	Lipoate-protein ligase
MICNX66_RS14650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MICNX66_RS14655	COG1834	amidinotransferase
MICNX66_RS14660	COG0604	alcohol dehydrogenase
MICNX66_RS14665	COG1476	TRANSCRIPTIONal
MICNX66_RS14675	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS14690	COG0183	Belongs to the thiolase family
MICNX66_RS14705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MICNX66_RS14755	COG0477	Major facilitator Superfamily
MICNX66_RS14765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MICNX66_RS14770	COG2079	MmgE PrpD family protein
MICNX66_RS14795	COG1175	transmembrane transport
MICNX66_RS14800	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS14810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MICNX66_RS14850	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS14865	COG0445	tRNA wobble uridine modification
MICNX66_RS14875	COG1349	DNA-binding transcription factor activity
MICNX66_RS14920	COG1172	Belongs to the binding-protein-dependent transport system permease family
MICNX66_RS14935	COG1609	Transcriptional regulator
MICNX66_RS14950	COG4948	Mandelate Racemase Muconate Lactonizing
MICNX66_RS14955	COG0179	Fumarylacetoacetate (FAA) hydrolase
MICNX66_RS14960	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS14970	COG2186	Transcriptional regulator
MICNX66_RS14975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MICNX66_RS14980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MICNX66_RS14985	COG1869	D-ribose catabolic process
MICNX66_RS14990	COG2188	Transcriptional regulator
MICNX66_RS14995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MICNX66_RS15005	COG2188	Transcriptional regulator
MICNX66_RS15020	COG1175	transmembrane transport
MICNX66_RS15025	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS15030	COG0667	Aldo Keto reductase
MICNX66_RS15040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MICNX66_RS15065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MICNX66_RS15085	COG1028	Short-chain dehydrogenase reductase Sdr
MICNX66_RS15100	COG0531	amino acid
MICNX66_RS15105	COG0076	glutamate decarboxylase activity
MICNX66_RS15115	COG1122	ATPase activity
MICNX66_RS15120	COG4721	ABC-type cobalt transport system, permease component
MICNX66_RS15125	COG1686	Belongs to the peptidase S11 family
MICNX66_RS15155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MICNX66_RS15170	COG0181	hydroxymethylbilane synthase activity
MICNX66_RS15175	COG3253	May function as heme-dependent peroxidase
MICNX66_RS15200	COG0640	Transcriptional regulator
MICNX66_RS15205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MICNX66_RS15210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MICNX66_RS15215	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MICNX66_RS15230	COG0488	(ABC) transporter
MICNX66_RS15240	COG0423	glycine-tRNA ligase activity
MICNX66_RS15245	COG3104	oligopeptide transport
MICNX66_RS15260	COG0477	Major facilitator Superfamily
MICNX66_RS15275	COG3590	peptidase
MICNX66_RS15280	COG2205	protein histidine kinase activity
MICNX66_RS15305	COG0534	Mate efflux family protein
MICNX66_RS15360	COG4948	Mandelate Racemase Muconate Lactonizing
MICNX66_RS15365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MICNX66_RS15370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MICNX66_RS15375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS15390	COG1737	Transcriptional regulator
MICNX66_RS15410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MICNX66_RS15420	COG0561	phosphatase activity
MICNX66_RS15435	COG2814	Major facilitator Superfamily
MICNX66_RS15445	COG2197	response regulator
MICNX66_RS15450	COG3135	benzoate transporter
MICNX66_RS15455	COG4152	abc transporter atp-binding protein
MICNX66_RS15460	COG1668	transmembrane transport
MICNX66_RS15465	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS15470	COG0583	DNA-binding transcription factor activity
MICNX66_RS15480	COG0542	response to heat
MICNX66_RS15515	COG0438	transferase activity, transferring glycosyl groups
MICNX66_RS15535	COG1609	Transcriptional regulator
MICNX66_RS15550	COG1175	transmembrane transport
MICNX66_RS15555	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS15595	COG1609	Transcriptional regulator
MICNX66_RS15610	COG4948	Mandelate Racemase Muconate Lactonizing
MICNX66_RS15615	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS15635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MICNX66_RS15665	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS15670	COG1175	transmembrane transport
MICNX66_RS15680	COG1215	transferase activity, transferring glycosyl groups
MICNX66_RS15685	COG1366	Belongs to the anti-sigma-factor antagonist family
MICNX66_RS15695	COG2259	Doxx family
MICNX66_RS15700	COG1802	Transcriptional regulator
MICNX66_RS15705	COG0789	Transcriptional regulator
MICNX66_RS15710	COG0484	heat shock protein binding
MICNX66_RS15715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MICNX66_RS15720	COG0443	Heat shock 70 kDa protein
MICNX66_RS15745	COG2207	Transcriptional regulator
MICNX66_RS15745	COG0662	Cupin 2, conserved barrel domain protein
MICNX66_RS15750	COG2814	Major facilitator Superfamily
MICNX66_RS15770	COG1228	amidohydrolase
MICNX66_RS15770	COG1228	amidohydrolase
MICNX66_RS15775	COG0477	Major facilitator Superfamily
MICNX66_RS15825	COG0717	Belongs to the dCTP deaminase family
MICNX66_RS15835	COG2409	Drug exporters of the RND superfamily
MICNX66_RS15860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MICNX66_RS15875	COG0598	Magnesium transport protein CorA
MICNX66_RS15890	COG5398	heme oxygenase
MICNX66_RS15895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MICNX66_RS15910	COG0776	regulation of translation
MICNX66_RS15915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MICNX66_RS15920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MICNX66_RS15925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MICNX66_RS15930	COG2094	Belongs to the DNA glycosylase MPG family
MICNX66_RS15945	COG0701	Predicted permease
MICNX66_RS15960	COG1121	(ABC) transporter
MICNX66_RS15965	COG0803	Belongs to the bacterial solute-binding protein 9 family
MICNX66_RS15970	COG0366	Alpha amylase catalytic
MICNX66_RS15975	COG0395	ABC-type sugar transport system, permease component
MICNX66_RS15980	COG1175	transmembrane transport
MICNX66_RS15985	COG2182	Extracellular solute-binding protein
MICNX66_RS15995	COG0640	Transcriptional regulator
MICNX66_RS16000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MICNX66_RS16005	COG0508	dehydrogenase complex catalyzes the overall conversion of
MICNX66_RS16010	COG0022	dehydrogenase e1 component
MICNX66_RS16020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MICNX66_RS16030	COG3654	unkown
MICNX66_RS16050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MICNX66_RS16060	COG0477	Major facilitator Superfamily
MICNX66_RS16085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MICNX66_RS16095	COG1396	sequence-specific DNA binding
MICNX66_RS16100	COG0740	serine-type endopeptidase activity
MICNX66_RS16105	COG0740	serine-type endopeptidase activity
MICNX66_RS16110	COG1607	acyl-coa hydrolase
MICNX66_RS16120	COG0626	cystathionine gamma-synthase activity
MICNX66_RS16140	COG0534	Mate efflux family protein
MICNX66_RS16145	COG1113	amino acid transport
MICNX66_RS16155	COG2197	response regulator
MICNX66_RS16160	COG4585	Histidine kinase
MICNX66_RS16165	COG1739	Uncharacterized protein family UPF0029
MICNX66_RS16185	COG0596	Alpha beta hydrolase
MICNX66_RS16190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MICNX66_RS16195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MICNX66_RS16200	COG2354	Protein conserved in bacteria
MICNX66_RS16230	COG1349	DNA-binding transcription factor activity
MICNX66_RS16250	COG0745	RESPONSE REGULATOR receiver
MICNX66_RS16255	COG2205	protein histidine kinase activity
MICNX66_RS16265	COG2501	S4 domain
MICNX66_RS16290	COG0305	Participates in initiation and elongation during chromosome replication
MICNX66_RS16305	COG0662	Cupin 2, conserved barrel domain protein
MICNX66_RS16310	COG2843	Capsule synthesis protein
MICNX66_RS16320	COG0359	binds to the 23S rRNA
MICNX66_RS16325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MICNX66_RS16335	COG0360	Binds together with S18 to 16S ribosomal RNA
MICNX66_RS16355	COG0444	Belongs to the ABC transporter superfamily
MICNX66_RS16360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MICNX66_RS16365	COG0601	transmembrane transport
MICNX66_RS16370	COG0747	negative chemotaxis
MICNX66_RS16410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MICNX66_RS16430	COG1012	belongs to the aldehyde dehydrogenase family
MICNX66_RS16445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MICNX66_RS16505	COG2890	protein-(glutamine-N5) methyltransferase activity
MICNX66_RS16520	COG0492	ferredoxin-NADP+ reductase activity
MICNX66_RS16525	COG3118	belongs to the thioredoxin family
MICNX66_RS16530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MICNX66_RS16540	COG0477	Major facilitator Superfamily
MICNX66_RS16550	COG1192	Involved in chromosome partitioning
MICNX66_RS16555	COG0357	Ribosomal RNA small subunit methyltransferase G
MICNX66_RS16565	COG0706	membrane insertase activity
MICNX66_RS16570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MICNX66_RS16580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MICNX66_RS16600	COG0662	Cupin 2, conserved barrel domain protein
MICNX66_RS16630	COG0739	heme binding
MICNX66_RS16755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MICNX66_RS16755	COG1017	nitric oxide dioxygenase activity
MICNX66_RS16775	COG0745	RESPONSE REGULATOR receiver