locus-tag	class	description
C1N74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1N74_RS00010	COG0592	DNA-directed DNA polymerase activity
C1N74_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1N74_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C1N74_RS00025	COG0187	DNA topoisomerase II activity
C1N74_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1N74_RS00055	COG1309	transcriptional regulator
C1N74_RS00080	COG0705	Rhomboid family
C1N74_RS00095	COG3764	Sortase (surface protein transpeptidase)
C1N74_RS00110	COG2815	serine threonine protein kinase
C1N74_RS00110	COG0515	serine threonine protein kinase
C1N74_RS00115	COG0515	serine threonine protein kinase
C1N74_RS00120	COG0768	penicillin binding
C1N74_RS00135	COG1716	ATPase activity
C1N74_RS00140	COG1716	ATPase activity
C1N74_RS00150	COG0454	-acetyltransferase
C1N74_RS00170	COG3655	Transcriptional regulator
C1N74_RS00195	COG0546	phosphoglycolate phosphatase activity
C1N74_RS00205	COG0667	Aldo Keto reductase
C1N74_RS00210	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C1N74_RS00230	COG0738	Major facilitator superfamily
C1N74_RS00235	COG1609	Transcriptional regulator
C1N74_RS00240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1N74_RS00240	COG2111	Na H antiporter
C1N74_RS00245	COG1006	Multisubunit Na H antiporter MnhC subunit
C1N74_RS00250	COG0651	ATP synthesis coupled electron transport
C1N74_RS00260	COG2212	antiporter activity
C1N74_RS00295	COG2378	regulation of single-species biofilm formation
C1N74_RS00300	COG2188	Transcriptional regulator
C1N74_RS00305	COG4948	Mandelate Racemase Muconate Lactonizing
C1N74_RS00310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1N74_RS00330	COG0137	argininosuccinate synthase activity
C1N74_RS00335	COG1464	Belongs to the NlpA lipoprotein family
C1N74_RS00340	COG2011	ABC-type metal ion transport system permease component
C1N74_RS00350	COG2814	Major facilitator Superfamily
C1N74_RS00390	COG0024	Methionine aminopeptidase
C1N74_RS00410	COG1280	lysine exporter protein (LysE YggA)
C1N74_RS00415	COG1609	Transcriptional regulator
C1N74_RS00420	COG1129	ABC transporter
C1N74_RS00425	COG4214	carbohydrate transport
C1N74_RS00435	COG0765	amino acid transport
C1N74_RS00465	COG4172	Belongs to the ABC transporter superfamily
C1N74_RS00475	COG0601	transmembrane transport
C1N74_RS00480	COG0747	negative chemotaxis
C1N74_RS00485	COG1120	ATPase activity
C1N74_RS00490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS00495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS00510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1N74_RS00515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1N74_RS00550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1N74_RS00565	COG1605	Chorismate mutase
C1N74_RS00565	COG0287	Prephenate dehydrogenase
C1N74_RS00585	COG4176	ABC-type proline glycine betaine transport system permease component
C1N74_RS00600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1N74_RS00630	COG0395	ABC-type sugar transport system, permease component
C1N74_RS00635	COG1175	transmembrane transport
C1N74_RS00655	COG1175	transmembrane transport
C1N74_RS00660	COG0395	ABC-type sugar transport system, permease component
C1N74_RS00695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1N74_RS00700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1N74_RS00705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1N74_RS00745	COG0822	iron-sulfur transferase activity
C1N74_RS00760	COG0531	amino acid
C1N74_RS00780	COG1609	Transcriptional regulator
C1N74_RS00785	COG0366	Alpha amylase catalytic
C1N74_RS00790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1N74_RS00795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1N74_RS00805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1N74_RS00835	COG1953	Uracil, thiamine, allantoin
C1N74_RS00845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1N74_RS00855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1N74_RS00865	COG0402	S-adenosylhomocysteine deaminase activity
C1N74_RS00870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1N74_RS00910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1N74_RS00915	COG0047	phosphoribosylformylglycinamidine synthase activity
C1N74_RS00920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1N74_RS00935	COG0395	ABC-type sugar transport system, permease component
C1N74_RS00940	COG2723	6-phospho-beta-galactosidase activity
C1N74_RS00950	COG2514	catechol 2,3-dioxygenase activity
C1N74_RS00955	COG2233	PERMEase
C1N74_RS00960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1N74_RS00985	COG0151	Belongs to the GarS family
C1N74_RS01000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS01005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1N74_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1N74_RS01025	COG2190	(PTS) system
C1N74_RS01025	COG1263	PTS System
C1N74_RS01040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1N74_RS01065	COG1695	Transcriptional regulator
C1N74_RS01085	COG2271	Major facilitator Superfamily
C1N74_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS01095	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1N74_RS01110	COG0149	triose-phosphate isomerase activity
C1N74_RS01115	COG0698	ribose 5-phosphate isomerase
C1N74_RS01120	COG2376	Dihydroxyacetone kinase
C1N74_RS01125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1N74_RS01130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1N74_RS01140	COG0513	Belongs to the DEAD box helicase family
C1N74_RS01155	COG1876	peptidase activity
C1N74_RS01170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1N74_RS01175	COG1122	ATPase activity
C1N74_RS01190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1N74_RS01195	COG1733	regulation of RNA biosynthetic process
C1N74_RS01235	COG4122	O-methyltransferase activity
C1N74_RS01255	COG1741	Belongs to the pirin family
C1N74_RS01265	COG1966	Carbon starvation protein
C1N74_RS01275	COG1472	Belongs to the glycosyl hydrolase 3 family
C1N74_RS01290	COG0395	ABC-type sugar transport system, permease component
C1N74_RS01295	COG4209	transmembrane transport
C1N74_RS01305	COG1609	Transcriptional regulator
C1N74_RS01310	COG4581	dead DEAH box helicase
C1N74_RS01320	COG0514	ATP-dependent DNA helicase (RecQ)
C1N74_RS01330	COG2818	Glycosylase
C1N74_RS01335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1N74_RS01345	COG0714	Associated with various cellular activities
C1N74_RS01365	COG0631	protein serine/threonine phosphatase activity
C1N74_RS01380	COG2815	serine threonine protein kinase
C1N74_RS01380	COG0515	serine threonine protein kinase
C1N74_RS01385	COG2409	Drug exporters of the RND superfamily
C1N74_RS01400	COG0025	NhaP-type Na H and K H
C1N74_RS01405	COG0039	L-malate dehydrogenase activity
C1N74_RS01430	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1N74_RS01435	COG1177	transmembrane transport
C1N74_RS01440	COG3842	ATPase activity
C1N74_RS01450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1N74_RS01455	COG0513	Belongs to the DEAD box helicase family
C1N74_RS01515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1N74_RS01520	COG0037	tRNA processing
C1N74_RS01525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1N74_RS01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1N74_RS01535	COG0302	gtp cyclohydrolase
C1N74_RS01545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1N74_RS01580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1N74_RS01595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1N74_RS01630	COG0154	amidase activity
C1N74_RS01635	COG2957	Belongs to the agmatine deiminase family
C1N74_RS01655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1N74_RS01660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1N74_RS01685	COG1012	belongs to the aldehyde dehydrogenase family
C1N74_RS01690	COG1960	acyl-CoA dehydrogenase activity
C1N74_RS01710	COG1609	Transcriptional regulator
C1N74_RS01720	COG4166	transmembrane transport
C1N74_RS01725	COG0601	transmembrane transport
C1N74_RS01730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS01735	COG0444	Belongs to the ABC transporter superfamily
C1N74_RS01740	COG4172	Belongs to the ABC transporter superfamily
C1N74_RS01750	COG2808	Putative FMN-binding domain
C1N74_RS01775	COG1472	Belongs to the glycosyl hydrolase 3 family
C1N74_RS01780	COG0395	ABC-type sugar transport system, permease component
C1N74_RS01785	COG1175	transmembrane transport
C1N74_RS01800	COG0717	Belongs to the dCTP deaminase family
C1N74_RS01830	COG0745	RESPONSE REGULATOR receiver
C1N74_RS01835	COG0443	Heat shock 70 kDa protein
C1N74_RS01840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1N74_RS01845	COG0484	heat shock protein binding
C1N74_RS01850	COG0789	Transcriptional regulator
C1N74_RS01880	COG4977	sequence-specific DNA binding
C1N74_RS01890	COG0542	response to heat
C1N74_RS01895	COG5297	Belongs to the glycosyl hydrolase family 6
C1N74_RS01895	COG3250	beta-galactosidase activity
C1N74_RS01915	COG3424	synthase
C1N74_RS01935	COG4152	abc transporter atp-binding protein
C1N74_RS01940	COG1120	ATPase activity
C1N74_RS01945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS01955	COG3387	PFAM Glycoside hydrolase 15-related
C1N74_RS01965	COG2197	response regulator
C1N74_RS01970	COG4585	Histidine kinase
C1N74_RS01985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1N74_RS01990	COG1902	pentaerythritol trinitrate reductase activity
C1N74_RS01995	COG1733	regulation of RNA biosynthetic process
C1N74_RS02035	COG0534	Mate efflux family protein
C1N74_RS02045	COG3590	peptidase
C1N74_RS02055	COG0789	Transcriptional regulator
C1N74_RS02055	COG4978	Transcriptional regulator
C1N74_RS02085	COG3104	oligopeptide transport
C1N74_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS02105	COG2268	Band 7 protein
C1N74_RS02110	COG0423	glycine-tRNA ligase activity
C1N74_RS02145	COG1587	Uroporphyrinogen-III synthase
C1N74_RS02165	COG1024	Enoyl-CoA hydratase
C1N74_RS02170	COG0484	heat shock protein binding
C1N74_RS02180	COG4721	ABC-type cobalt transport system, permease component
C1N74_RS02185	COG1122	ATPase activity
C1N74_RS02200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1N74_RS02205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1N74_RS02210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1N74_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS02240	COG2423	ornithine cyclodeaminase activity
C1N74_RS02245	COG0402	S-adenosylhomocysteine deaminase activity
C1N74_RS02255	COG4172	Belongs to the ABC transporter superfamily
C1N74_RS02260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS02280	COG0561	phosphatase activity
C1N74_RS02285	COG2040	homocysteine
C1N74_RS02300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1N74_RS02300	COG2190	(PTS) system
C1N74_RS02300	COG1263	PTS System
C1N74_RS02310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1N74_RS02315	COG0667	Aldo Keto reductase
C1N74_RS02365	COG0328	RNA-DNA hybrid ribonuclease activity
C1N74_RS02375	COG2079	MmgE PrpD family protein
C1N74_RS02380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1N74_RS02395	COG1024	Enoyl-CoA hydratase
C1N74_RS02420	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1N74_RS02430	COG1609	Transcriptional regulator
C1N74_RS02445	COG0395	ABC-type sugar transport system, permease component
C1N74_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
C1N74_RS02470	COG0667	Aldo Keto reductase
C1N74_RS02485	COG0601	transmembrane transport
C1N74_RS02490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS02500	COG4608	Belongs to the ABC transporter superfamily
C1N74_RS02515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C1N74_RS02530	COG1305	Transglutaminase-like
C1N74_RS02545	COG1070	Carbohydrate kinase
C1N74_RS02550	COG3347	Dehydrogenase
C1N74_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS02560	COG2814	Major facilitator Superfamily
C1N74_RS02575	COG1609	Transcriptional regulator
C1N74_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS02590	COG2084	Dehydrogenase
C1N74_RS02595	COG1082	Xylose isomerase domain protein TIM barrel
C1N74_RS02600	COG0149	triose-phosphate isomerase activity
C1N74_RS02605	COG0698	ribose 5-phosphate isomerase
C1N74_RS02610	COG2376	Dihydroxyacetone kinase
C1N74_RS02630	COG3250	beta-galactosidase activity
C1N74_RS02670	COG3250	beta-galactosidase activity
C1N74_RS02685	COG1846	Transcriptional regulator
C1N74_RS02700	COG1136	(ABC) transporter
C1N74_RS02705	COG0095	Lipoate-protein ligase
C1N74_RS02735	COG1595	DNA-templated transcription, initiation
C1N74_RS02740	COG1302	Protein conserved in bacteria
C1N74_RS02765	COG3237	CsbD-like
C1N74_RS02770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1N74_RS02795	COG3534	alpha-L-arabinofuranosidase
C1N74_RS02800	COG1653	transport
C1N74_RS02805	COG0395	ABC-type sugar transport system, permease component
C1N74_RS02810	COG1175	transmembrane transport
C1N74_RS02815	COG1609	Transcriptional regulator
C1N74_RS02825	COG3401	FG-GAP repeat protein
C1N74_RS02850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1N74_RS02860	COG0673	inositol 2-dehydrogenase activity
C1N74_RS02865	COG1609	Transcriptional regulator
C1N74_RS02900	COG1175	transmembrane transport
C1N74_RS02905	COG0395	ABC-type sugar transport system, permease component
C1N74_RS02920	COG1132	(ABC) transporter
C1N74_RS02935	COG1175	transmembrane transport
C1N74_RS02940	COG0395	ABC-type sugar transport system, permease component
C1N74_RS02955	COG3534	alpha-L-arabinofuranosidase
C1N74_RS02960	COG0673	inositol 2-dehydrogenase activity
C1N74_RS02975	COG1609	Transcriptional regulator
C1N74_RS02980	COG1929	Belongs to the glycerate kinase type-1 family
C1N74_RS02985	COG0110	maltose O-acetyltransferase activity
C1N74_RS02990	COG1609	Transcriptional regulator
C1N74_RS03010	COG1175	transmembrane transport
C1N74_RS03015	COG0395	ABC-type sugar transport system, permease component
C1N74_RS03030	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1N74_RS03035	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS03040	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C1N74_RS03050	COG0800	Aldolase
C1N74_RS03055	COG0604	alcohol dehydrogenase
C1N74_RS03085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1N74_RS03090	COG0415	Belongs to the DNA photolyase family
C1N74_RS03095	COG1597	lipid kinase activity
C1N74_RS03100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1N74_RS03105	COG0561	phosphatase activity
C1N74_RS03125	COG1316	TRANSCRIPTIONal
C1N74_RS03185	COG1216	Glycosyl transferase, family 2
C1N74_RS03190	COG0297	glycogen (starch) synthase activity
C1N74_RS03200	COG0438	transferase activity, transferring glycosyl groups
C1N74_RS03205	COG4221	oxidoreductase activity
C1N74_RS03210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1N74_RS03210	COG2190	(PTS) system
C1N74_RS03210	COG1263	PTS System
C1N74_RS03215	COG2723	6-phospho-beta-galactosidase activity
C1N74_RS03220	COG3711	transcriptional antiterminator
C1N74_RS03230	COG3971	2-oxopent-4-enoate hydratase activity
C1N74_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
C1N74_RS03255	COG0477	Major facilitator Superfamily
C1N74_RS03325	COG1546	Belongs to the CinA family
C1N74_RS03325	COG1058	Belongs to the CinA family
C1N74_RS03355	COG2873	o-acetylhomoserine
C1N74_RS03360	COG2897	thiosulfate sulfurtransferase activity
C1N74_RS03370	COG0778	Nitroreductase
C1N74_RS03390	COG1289	transmembrane transporter activity
C1N74_RS03410	COG1609	Transcriptional regulator
C1N74_RS03420	COG2160	L-arabinose isomerase activity
C1N74_RS03425	COG2017	converts alpha-aldose to the beta-anomer
C1N74_RS03465	COG1760	l-serine dehydratase
C1N74_RS03500	COG1228	amidohydrolase
C1N74_RS03515	COG1854	S-ribosylhomocysteine lyase activity
C1N74_RS03535	COG0492	ferredoxin-NADP+ reductase activity
C1N74_RS03540	COG1396	sequence-specific DNA binding
C1N74_RS03545	COG0166	Belongs to the GPI family
C1N74_RS03550	COG1121	(ABC) transporter
C1N74_RS03555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1N74_RS03565	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1N74_RS03585	COG2814	Major facilitator Superfamily
C1N74_RS03595	COG2197	response regulator
C1N74_RS03605	COG0561	phosphatase activity
C1N74_RS03615	COG0823	Involved in the tonB-independent uptake of proteins
C1N74_RS03615	COG1506	peptidase
C1N74_RS03670	COG0745	RESPONSE REGULATOR receiver
C1N74_RS03705	COG0419	ATPase involved in DNA repair
C1N74_RS03715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1N74_RS03735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1N74_RS03740	COG0590	tRNA wobble adenosine to inosine editing
C1N74_RS03750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1N74_RS03755	COG0569	domain protein
C1N74_RS03760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1N74_RS03800	COG0017	Asparaginyl-tRNA synthetase
C1N74_RS03805	COG0586	Pfam SNARE associated Golgi protein
C1N74_RS03810	COG0406	alpha-ribazole phosphatase activity
C1N74_RS03820	COG0785	Cytochrome C biogenesis protein
C1N74_RS03825	COG1333	cytochrome c biogenesis protein
C1N74_RS03830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1N74_RS03840	COG2409	Drug exporters of the RND superfamily
C1N74_RS03850	COG4948	Mandelate Racemase Muconate Lactonizing
C1N74_RS03855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1N74_RS03880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1N74_RS03895	COG2226	methyltransferase
C1N74_RS03900	COG0142	geranyltranstransferase activity
C1N74_RS03915	COG1653	transport
C1N74_RS03945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1N74_RS03950	COG1609	Transcriptional regulator
C1N74_RS04060	COG0582	viral genome integration into host DNA
C1N74_RS04065	COG1666	GTP binding
C1N74_RS04105	COG0515	serine threonine protein kinase
C1N74_RS04115	COG2197	response regulator
C1N74_RS04130	COG0483	inositol monophosphate 1-phosphatase activity
C1N74_RS04135	COG0739	heme binding
C1N74_RS04135	COG1196	nuclear chromosome segregation
C1N74_RS04135	COG0741	lytic transglycosylase activity
C1N74_RS04165	COG3387	PFAM Glycoside hydrolase 15-related
C1N74_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS04180	COG1846	Transcriptional regulator
C1N74_RS04185	COG1764	response to oxidative stress
C1N74_RS04190	COG2357	RelA SpoT domain protein
C1N74_RS04210	COG0730	response to heat
C1N74_RS04215	COG2030	dehydratase
C1N74_RS04225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1N74_RS04235	COG0436	Aminotransferase
C1N74_RS04250	COG4585	Histidine kinase
C1N74_RS04255	COG2197	response regulator
C1N74_RS04265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1N74_RS04290	COG1113	amino acid transport
C1N74_RS04315	COG1012	belongs to the aldehyde dehydrogenase family
C1N74_RS04325	COG0326	Molecular chaperone. Has ATPase activity
C1N74_RS04350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1N74_RS04355	COG0081	regulation of translation
C1N74_RS04365	COG1254	Belongs to the acylphosphatase family
C1N74_RS04380	COG0604	alcohol dehydrogenase
C1N74_RS04380	COG3321	synthase
C1N74_RS04410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1N74_RS04415	COG0222	ribosome binding
C1N74_RS04420	COG1609	Transcriptional regulator
C1N74_RS04425	COG1653	transport
C1N74_RS04430	COG1175	transmembrane transport
C1N74_RS04435	COG0395	ABC-type sugar transport system, permease component
C1N74_RS04450	COG2814	Major facilitator Superfamily
C1N74_RS04460	COG0433	COG0433 Predicted ATPase
C1N74_RS04465	COG0477	Major facilitator Superfamily
C1N74_RS04470	COG0702	epimerase
C1N74_RS04475	COG0315	cyclic pyranopterin monophosphate synthase activity
C1N74_RS04475	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1N74_RS04480	COG0314	molybdopterin synthase activity
C1N74_RS04490	COG0315	cyclic pyranopterin monophosphate synthase activity
C1N74_RS04505	COG3585	molybdate ion transport
C1N74_RS04525	COG0456	acetyltransferase
C1N74_RS04530	COG4988	ABC transporter
C1N74_RS04535	COG4988	ABC transporter
C1N74_RS04540	COG1294	oxidase, subunit
C1N74_RS04545	COG1271	oxidase subunit
C1N74_RS04550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1N74_RS04570	COG0667	Aldo Keto reductase
C1N74_RS04595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1N74_RS04605	COG0702	epimerase
C1N74_RS04610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1N74_RS04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS04620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS04625	COG1120	ATPase activity
C1N74_RS04630	COG2375	cellular response to nickel ion
C1N74_RS04645	COG1054	Belongs to the UPF0176 family
C1N74_RS04695	COG0463	Glycosyl transferase, family 2
C1N74_RS04705	COG0534	Mate efflux family protein
C1N74_RS04715	COG2205	protein histidine kinase activity
C1N74_RS04720	COG0745	RESPONSE REGULATOR receiver
C1N74_RS04730	COG1362	aminopeptidase activity
C1N74_RS04745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1N74_RS04755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1N74_RS04760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1N74_RS04765	COG0702	epimerase
C1N74_RS04770	COG1733	regulation of RNA biosynthetic process
C1N74_RS04775	COG1695	Transcriptional regulator
C1N74_RS04780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1N74_RS04785	COG0494	nUDIX hydrolase
C1N74_RS04790	COG0490	domain, Protein
C1N74_RS04790	COG0471	metal ion transport
C1N74_RS04800	COG2133	pyrroloquinoline quinone binding
C1N74_RS04810	COG0028	Belongs to the TPP enzyme family
C1N74_RS04815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1N74_RS04820	COG3340	Belongs to the peptidase S51 family
C1N74_RS04860	COG1823	symporter activity
C1N74_RS04875	COG0714	Associated with various cellular activities
C1N74_RS04890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1N74_RS04905	COG2072	flavoprotein involved in K transport
C1N74_RS04915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1N74_RS04935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1N74_RS04960	COG0395	ABC-type sugar transport system, permease component
C1N74_RS04975	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1N74_RS04985	COG0545	Peptidyl-prolyl cis-trans isomerase
C1N74_RS05000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1N74_RS05010	COG3594	Acyltransferase
C1N74_RS05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1N74_RS05030	COG0438	transferase activity, transferring glycosyl groups
C1N74_RS05035	COG4565	transcriptional regulatory protein
C1N74_RS05040	COG3290	protein histidine kinase activity
C1N74_RS05045	COG1301	dicarboxylic acid transport
C1N74_RS05060	COG1185	polyribonucleotide nucleotidyltransferase activity
C1N74_RS05065	COG0667	Aldo Keto reductase
C1N74_RS05095	COG1090	epimerase
C1N74_RS05110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1N74_RS05125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1N74_RS05130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C1N74_RS05135	COG1674	ftsk spoiiie
C1N74_RS05145	COG1546	Belongs to the CinA family
C1N74_RS05145	COG1058	Belongs to the CinA family
C1N74_RS05150	COG1396	sequence-specific DNA binding
C1N74_RS05160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1N74_RS05175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1N74_RS05180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1N74_RS05185	COG0456	acetyltransferase
C1N74_RS05190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1N74_RS05195	COG2813	Specifically methylates the guanine in position
C1N74_RS05200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1N74_RS05210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1N74_RS05220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1N74_RS05225	COG0131	Imidazoleglycerol-phosphate dehydratase
C1N74_RS05230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1N74_RS05235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1N74_RS05250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1N74_RS05255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1N74_RS05260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1N74_RS05265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1N74_RS05270	COG1126	abc transporter atp-binding protein
C1N74_RS05280	COG0765	amino acid transport
C1N74_RS05285	COG0765	amino acid transport
C1N74_RS05290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1N74_RS05295	COG0072	phenylalanine-tRNA ligase activity
C1N74_RS05295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1N74_RS05300	COG1196	nuclear chromosome segregation
C1N74_RS05320	COG1131	(ABC) transporter
C1N74_RS05335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1N74_RS05340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1N74_RS05345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1N74_RS05355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1N74_RS05365	COG0165	Argininosuccinate lyase
C1N74_RS05380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1N74_RS05445	COG2205	protein histidine kinase activity
C1N74_RS05450	COG0745	RESPONSE REGULATOR receiver
C1N74_RS05465	COG1136	(ABC) transporter
C1N74_RS05485	COG1309	transcriptional regulator
C1N74_RS05525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1N74_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
C1N74_RS05545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1N74_RS05570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1N74_RS05580	COG1175	transmembrane transport
C1N74_RS05585	COG3833	ABC-type maltose transport systems, permease component
C1N74_RS05610	COG3250	beta-galactosidase activity
C1N74_RS05610	COG5297	Belongs to the glycosyl hydrolase family 6
C1N74_RS05620	COG0745	RESPONSE REGULATOR receiver
C1N74_RS05625	COG2205	protein histidine kinase activity
C1N74_RS05640	COG1780	Probably involved in ribonucleotide reductase function
C1N74_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
C1N74_RS05645	COG1454	alcohol dehydrogenase
C1N74_RS05650	COG0667	Aldo Keto reductase
C1N74_RS05695	COG2372	response to copper ion
C1N74_RS05700	COG1716	ATPase activity
C1N74_RS05715	COG1192	Involved in chromosome partitioning
C1N74_RS05735	COG1022	Amp-dependent synthetase and ligase
C1N74_RS05740	COG1940	carbohydrate kinase activity
C1N74_RS05745	COG0204	Acyl-transferase
C1N74_RS05750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1N74_RS05760	COG0515	serine threonine protein kinase
C1N74_RS05760	COG2815	serine threonine protein kinase
C1N74_RS05775	COG0142	geranyltranstransferase activity
C1N74_RS05785	COG2001	Belongs to the MraZ family
C1N74_RS05790	COG0275	rRNA processing
C1N74_RS05800	COG0768	penicillin binding
C1N74_RS05810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1N74_RS05815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1N74_RS05825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1N74_RS05830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1N74_RS05845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1N74_RS05850	COG1799	cell septum assembly
C1N74_RS05865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1N74_RS05895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1N74_RS05900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1N74_RS05905	COG0167	dihydroorotate dehydrogenase activity
C1N74_RS05925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1N74_RS05930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1N74_RS05945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1N74_RS05950	COG0723	plastoquinol--plastocyanin reductase activity
C1N74_RS05955	COG2010	Cytochrome c
C1N74_RS05960	COG1845	cytochrome c oxidase, subunit III
C1N74_RS05965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1N74_RS05975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1N74_RS05975	COG1796	DNA polymerase
C1N74_RS05980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1N74_RS05995	COG3012	SEC-C Motif Domain Protein
C1N74_RS06000	COG0539	negative regulation of cytoplasmic translation
C1N74_RS06005	COG5002	protein histidine kinase activity
C1N74_RS06015	COG0745	RESPONSE REGULATOR receiver
C1N74_RS06020	COG0237	dephospho-CoA kinase activity
C1N74_RS06025	COG0556	nucleotide-excision repair
C1N74_RS06035	COG1846	Transcriptional regulator
C1N74_RS06045	COG0322	excinuclease ABC activity
C1N74_RS06050	COG1660	Displays ATPase and GTPase activities
C1N74_RS06055	COG1481	regulation of sporulation
C1N74_RS06060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1N74_RS06065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1N74_RS06070	COG0126	phosphoglycerate kinase activity
C1N74_RS06075	COG0149	triose-phosphate isomerase activity
C1N74_RS06080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1N74_RS06090	COG0363	glucosamine-6-phosphate deaminase activity
C1N74_RS06105	COG0166	Belongs to the GPI family
C1N74_RS06110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1N74_RS06120	COG0109	protoheme IX farnesyltransferase activity
C1N74_RS06150	COG0396	ATPase activity
C1N74_RS06155	COG2151	metal-sulfur cluster biosynthetic enzyme
C1N74_RS06160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1N74_RS06170	COG1120	ATPase activity
C1N74_RS06175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS06180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1N74_RS06190	COG0488	(ABC) transporter
C1N74_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS06230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1N74_RS06235	COG0297	glycogen (starch) synthase activity
C1N74_RS06240	COG1119	ATPase activity
C1N74_RS06245	COG0254	rRNA binding
C1N74_RS06250	COG2860	membrane
C1N74_RS06255	COG1381	Involved in DNA repair and RecF pathway recombination
C1N74_RS06260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1N74_RS06270	COG0386	Belongs to the glutathione peroxidase family
C1N74_RS06280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1N74_RS06285	COG0358	DNA primase activity
C1N74_RS06290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1N74_RS06300	COG2066	Belongs to the glutaminase family
C1N74_RS06335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1N74_RS06340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1N74_RS06355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1N74_RS06435	COG0174	glutamine synthetase
C1N74_RS06440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1N74_RS06445	COG2354	Protein conserved in bacteria
C1N74_RS06500	COG0174	glutamine synthetase
C1N74_RS06520	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1N74_RS06525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1N74_RS06530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1N74_RS06540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1N74_RS06565	COG0187	DNA topoisomerase II activity
C1N74_RS06570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1N74_RS06595	COG0756	dUTP diphosphatase activity
C1N74_RS06610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1N74_RS06615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1N74_RS06635	COG1024	Enoyl-CoA hydratase
C1N74_RS06635	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1N74_RS06640	COG0183	Belongs to the thiolase family
C1N74_RS06645	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1N74_RS06665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1N74_RS06720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1N74_RS06735	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1N74_RS06745	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C1N74_RS06750	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C1N74_RS06755	COG0217	transcriptional regulatory protein
C1N74_RS06760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1N74_RS06765	COG0632	four-way junction helicase activity
C1N74_RS06770	COG2255	four-way junction helicase activity
C1N74_RS06780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1N74_RS06785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1N74_RS06790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1N74_RS06800	COG1196	nuclear chromosome segregation
C1N74_RS06820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1N74_RS06830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1N74_RS06835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1N74_RS06840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1N74_RS06845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1N74_RS06850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1N74_RS06855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1N74_RS06860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1N74_RS06865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1N74_RS06870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1N74_RS06875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1N74_RS06880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1N74_RS06905	COG1233	COG1233 Phytoene dehydrogenase and related
C1N74_RS06915	COG0142	geranyltranstransferase activity
C1N74_RS06920	COG1846	Transcriptional regulator
C1N74_RS06935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1N74_RS06945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1N74_RS06950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C1N74_RS06950	COG0463	Glycosyl transferase, family 2
C1N74_RS06955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C1N74_RS06980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1N74_RS07005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1N74_RS07010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1N74_RS07015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1N74_RS07020	COG1793	dna ligase
C1N74_RS07020	COG3285	dna ligase
C1N74_RS07025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C1N74_RS07030	COG0586	Pfam SNARE associated Golgi protein
C1N74_RS07060	COG1473	amidohydrolase
C1N74_RS07065	COG2814	Major facilitator Superfamily
C1N74_RS07140	COG1215	transferase activity, transferring glycosyl groups
C1N74_RS07155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1N74_RS07160	COG2884	Cell division ATP-binding protein ftsE
C1N74_RS07165	COG2177	Part of the ABC transporter FtsEX involved in
C1N74_RS07170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1N74_RS07195	COG0483	inositol monophosphate 1-phosphatase activity
C1N74_RS07210	COG0183	Belongs to the thiolase family
C1N74_RS07220	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C1N74_RS07230	COG0129	dihydroxy-acid dehydratase activity
C1N74_RS07235	COG0028	Belongs to the TPP enzyme family
C1N74_RS07245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1N74_RS07275	COG0477	Major facilitator Superfamily
C1N74_RS07280	COG0473	3-isopropylmalate dehydrogenase activity
C1N74_RS07285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1N74_RS07290	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1N74_RS07295	COG2814	Major facilitator Superfamily
C1N74_RS07305	COG0583	DNA-binding transcription factor activity
C1N74_RS07310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1N74_RS07330	COG1063	alcohol dehydrogenase
C1N74_RS07355	COG1349	DNA-binding transcription factor activity
C1N74_RS07360	COG1105	Belongs to the carbohydrate kinase PfkB family
C1N74_RS07365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1N74_RS07365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1N74_RS07365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1N74_RS07375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1N74_RS07400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1N74_RS07405	COG0066	3-isopropylmalate dehydratase activity
C1N74_RS07410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1N74_RS07420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1N74_RS07425	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1N74_RS07435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1N74_RS07440	COG0742	ribosomal rna small subunit methyltransferase
C1N74_RS07455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1N74_RS07465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1N74_RS07470	COG0571	ribonuclease III activity
C1N74_RS07475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1N74_RS07490	COG1196	nuclear chromosome segregation
C1N74_RS07495	COG0552	protein localization to endoplasmic reticulum
C1N74_RS07510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1N74_RS07515	COG0321	lipoyl(octanoyl) transferase activity
C1N74_RS07530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1N74_RS07535	COG0228	four-way junction DNA binding
C1N74_RS07540	COG1837	Belongs to the UPF0109 family
C1N74_RS07545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1N74_RS07550	COG0336	Belongs to the RNA methyltransferase TrmD family
C1N74_RS07565	COG0335	large ribosomal subunit rRNA binding
C1N74_RS07575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1N74_RS07585	COG0792	nuclease activity
C1N74_RS07600	COG3422	double-strand break repair
C1N74_RS07705	COG4974	Belongs to the 'phage' integrase family
C1N74_RS07720	COG0052	Belongs to the universal ribosomal protein uS2 family
C1N74_RS07725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1N74_RS07730	COG0528	UMP kinase activity
C1N74_RS07735	COG0233	cytoplasmic translational termination
C1N74_RS07775	COG3118	belongs to the thioredoxin family
C1N74_RS07780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1N74_RS07785	COG0366	Alpha amylase catalytic
C1N74_RS07800	COG0482	sulfurtransferase activity
C1N74_RS07805	COG1090	epimerase
C1N74_RS07815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1N74_RS07820	COG0318	PFAM AMP-dependent synthetase and ligase
C1N74_RS07825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1N74_RS07830	COG0154	amidase activity
C1N74_RS07835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1N74_RS07840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1N74_RS07855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1N74_RS07870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1N74_RS07890	COG4209	transmembrane transport
C1N74_RS07895	COG0395	ABC-type sugar transport system, permease component
C1N74_RS07920	COG2364	Membrane
C1N74_RS07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1N74_RS07935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1N74_RS07940	COG0629	single-stranded DNA binding
C1N74_RS07960	COG1946	Acyl-CoA thioesterase
C1N74_RS07975	COG0668	transmembrane transport
C1N74_RS07980	COG2197	response regulator
C1N74_RS07985	COG4585	Histidine kinase
C1N74_RS07995	COG1131	(ABC) transporter
C1N74_RS08005	COG0698	ribose 5-phosphate isomerase
C1N74_RS08025	COG0783	Belongs to the Dps family
C1N74_RS08045	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1N74_RS08050	COG0740	serine-type endopeptidase activity
C1N74_RS08055	COG0740	serine-type endopeptidase activity
C1N74_RS08060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1N74_RS08070	COG0339	signal peptide processing
C1N74_RS08090	COG0525	valine-tRNA ligase activity
C1N74_RS08095	COG1464	Belongs to the NlpA lipoprotein family
C1N74_RS08100	COG2011	ABC-type metal ion transport system permease component
C1N74_RS08105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1N74_RS08115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1N74_RS08125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1N74_RS08130	COG0285	dihydrofolate synthase activity
C1N74_RS08140	COG0105	UTP biosynthetic process
C1N74_RS08150	COG1530	ribonuclease E activity
C1N74_RS08160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1N74_RS08165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1N74_RS08170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1N74_RS08175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1N74_RS08180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1N74_RS08190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1N74_RS08200	COG0799	negative regulation of ribosome biogenesis
C1N74_RS08230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1N74_RS08230	COG0512	Glutamine amidotransferase of anthranilate synthase
C1N74_RS08235	COG0495	leucyl-tRNA aminoacylation
C1N74_RS08250	COG0076	glutamate decarboxylase activity
C1N74_RS08255	COG0531	amino acid
C1N74_RS08260	COG1555	photosystem II stabilization
C1N74_RS08260	COG1596	polysaccharide export
C1N74_RS08275	COG1063	alcohol dehydrogenase
C1N74_RS08285	COG0268	Binds directly to 16S ribosomal RNA
C1N74_RS08300	COG0481	GTPase activity
C1N74_RS08315	COG1420	regulation of RNA biosynthetic process
C1N74_RS08320	COG0484	heat shock protein binding
C1N74_RS08330	COG0537	adenosine 5'-monophosphoramidase activity
C1N74_RS08340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1N74_RS08350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1N74_RS08360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1N74_RS08390	COG0406	alpha-ribazole phosphatase activity
C1N74_RS08405	COG2755	lipolytic protein G-D-S-L family
C1N74_RS08420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1N74_RS08425	COG1968	undecaprenyl-diphosphatase activity
C1N74_RS08435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1N74_RS08445	COG0545	Peptidyl-prolyl cis-trans isomerase
C1N74_RS08460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1N74_RS08465	COG0805	protein transport
C1N74_RS08505	COG1506	peptidase
C1N74_RS08505	COG0823	Involved in the tonB-independent uptake of proteins
C1N74_RS08505	COG4946	Tricorn protease homolog
C1N74_RS08560	COG0477	Major facilitator Superfamily
C1N74_RS08565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1N74_RS08595	COG0469	pyruvate kinase activity
C1N74_RS08605	COG0069	glutamate synthase activity
C1N74_RS08605	COG0067	glutamate synthase
C1N74_RS08605	COG0070	glutamate synthase
C1N74_RS08610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1N74_RS08615	COG0159	tryptophan synthase activity
C1N74_RS08620	COG0133	tryptophan synthase activity
C1N74_RS08625	COG0134	indole-3-glycerol-phosphate synthase activity
C1N74_RS08640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1N74_RS08645	COG0107	imidazoleglycerol-phosphate synthase activity
C1N74_RS08650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1N74_RS08655	COG0140	phosphoribosyl-ATP diphosphatase activity
C1N74_RS08660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1N74_RS08670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1N74_RS08675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1N74_RS08680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1N74_RS08685	COG1758	RNA polymerase activity
C1N74_RS08690	COG0194	GDP metabolic process
C1N74_RS08700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1N74_RS08705	COG0505	Belongs to the CarA family
C1N74_RS08715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1N74_RS08720	COG0540	Belongs to the ATCase OTCase family
C1N74_RS08725	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1N74_RS08730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1N74_RS08755	COG3425	synthase
C1N74_RS08760	COG1615	UPF0182 protein
C1N74_RS08765	COG3480	Lon protease (S16) C-terminal proteolytic domain
C1N74_RS08795	COG0210	DNA helicase
C1N74_RS08800	COG1074	ATP-dependent DNA helicase activity
C1N74_RS08820	COG0513	Belongs to the DEAD box helicase family
C1N74_RS08835	COG0006	proline dipeptidase activity
C1N74_RS08840	COG0405	Gamma-glutamyltransferase
C1N74_RS08855	COG2239	Acts as a magnesium transporter
C1N74_RS08870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1N74_RS08875	COG4122	O-methyltransferase activity
C1N74_RS08890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1N74_RS08900	COG1620	l-lactate permease
C1N74_RS08905	COG2326	polyphosphate kinase activity
C1N74_RS08940	COG1217	gtp-binding protein TYPA
C1N74_RS08960	COG0747	negative chemotaxis
C1N74_RS08975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS08980	COG0601	transmembrane transport
C1N74_RS08985	COG4166	transmembrane transport
C1N74_RS08995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1N74_RS09010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1N74_RS09010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1N74_RS09015	COG0509	glycine decarboxylation via glycine cleavage system
C1N74_RS09020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1N74_RS09035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1N74_RS09040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1N74_RS09050	COG1104	cysteine desulfurase activity
C1N74_RS09060	COG2814	Major facilitator Superfamily
C1N74_RS09065	COG0693	protein deglycase activity
C1N74_RS09095	COG1063	alcohol dehydrogenase
C1N74_RS09100	COG0783	Belongs to the Dps family
C1N74_RS09110	COG0012	GTP binding
C1N74_RS09130	COG1322	Protein conserved in bacteria
C1N74_RS09140	COG1494	fructose-1,6-bisphosphatase
C1N74_RS09145	COG0191	fructose-bisphosphate aldolase activity
C1N74_RS09155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1N74_RS09160	COG1570	exodeoxyribonuclease VII activity
C1N74_RS09165	COG1722	exodeoxyribonuclease VII activity
C1N74_RS09175	COG0288	reversible hydration of carbon dioxide
C1N74_RS09180	COG0114	fumarate hydratase activity
C1N74_RS09185	COG2205	protein histidine kinase activity
C1N74_RS09195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1N74_RS09200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1N74_RS09220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1N74_RS09225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1N74_RS09235	COG1704	LemA family
C1N74_RS09245	COG0697	spore germination
C1N74_RS09275	COG0148	phosphopyruvate hydratase activity
C1N74_RS09280	COG4122	O-methyltransferase activity
C1N74_RS09300	COG0124	histidyl-tRNA synthetase
C1N74_RS09310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1N74_RS09315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1N74_RS09330	COG0193	aminoacyl-tRNA hydrolase activity
C1N74_RS09335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1N74_RS09340	COG1063	alcohol dehydrogenase
C1N74_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS09350	COG2610	gluconate transmembrane transporter activity
C1N74_RS09355	COG1802	Transcriptional regulator
C1N74_RS09370	COG0800	Aldolase
C1N74_RS09380	COG0598	Magnesium transport protein CorA
C1N74_RS09385	COG0745	RESPONSE REGULATOR receiver
C1N74_RS09390	COG2205	protein histidine kinase activity
C1N74_RS09405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1N74_RS09405	COG1017	nitric oxide dioxygenase activity
C1N74_RS09425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1N74_RS09430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1N74_RS09445	COG0488	(ABC) transporter
C1N74_RS09455	COG1174	glycine betaine transport
C1N74_RS09460	COG1174	glycine betaine transport
C1N74_RS09465	COG1125	glycine betaine transport
C1N74_RS09465	COG0517	IMP dehydrogenase activity
C1N74_RS09475	COG4552	Acetyltransferase involved in intracellular survival and related
C1N74_RS09480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1N74_RS09485	COG0667	Aldo Keto reductase
C1N74_RS09500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1N74_RS09505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1N74_RS09510	COG0113	porphobilinogen synthase activity
C1N74_RS09520	COG0181	hydroxymethylbilane synthase activity
C1N74_RS09525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1N74_RS09530	COG3253	May function as heme-dependent peroxidase
C1N74_RS09540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1N74_RS09545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1N74_RS09550	COG1609	Transcriptional regulator
C1N74_RS09555	COG0084	hydrolase, TatD family'
C1N74_RS09560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1N74_RS09580	COG1175	transmembrane transport
C1N74_RS09585	COG3833	ABC-type maltose transport systems, permease component
C1N74_RS09590	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C1N74_RS09620	COG0714	Associated with various cellular activities
C1N74_RS09640	COG0631	protein serine/threonine phosphatase activity
C1N74_RS09655	COG1643	Atp-dependent helicase
C1N74_RS09665	COG4214	carbohydrate transport
C1N74_RS09685	COG1609	Transcriptional regulator
C1N74_RS09695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1N74_RS09700	COG0673	inositol 2-dehydrogenase activity
C1N74_RS09705	COG2851	Citrate transporter
C1N74_RS09710	COG3290	protein histidine kinase activity
C1N74_RS09715	COG4565	transcriptional regulatory protein
C1N74_RS09725	COG2813	Specifically methylates the guanine in position
C1N74_RS09730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1N74_RS09765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS09770	COG0601	transmembrane transport
C1N74_RS09775	COG4166	transmembrane transport
C1N74_RS09805	COG2814	Major facilitator Superfamily
C1N74_RS09815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1N74_RS09825	COG1690	Belongs to the RtcB family
C1N74_RS09830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1N74_RS09835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1N74_RS09840	COG1780	Probably involved in ribonucleotide reductase function
C1N74_RS09865	COG1937	Protein conserved in bacteria
C1N74_RS09870	COG2733	membrane
C1N74_RS09875	COG2062	phosphohistidine phosphatase, SixA
C1N74_RS09890	COG2239	Acts as a magnesium transporter
C1N74_RS09895	COG4172	Belongs to the ABC transporter superfamily
C1N74_RS09900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS09910	COG0747	negative chemotaxis
C1N74_RS09935	COG2828	Protein conserved in bacteria
C1N74_RS09940	COG0583	DNA-binding transcription factor activity
C1N74_RS09950	COG0402	S-adenosylhomocysteine deaminase activity
C1N74_RS09965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1N74_RS09980	COG1970	mechanosensitive ion channel activity
C1N74_RS09995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1N74_RS10000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1N74_RS10010	COG2197	response regulator
C1N74_RS10015	COG0438	transferase activity, transferring glycosyl groups
C1N74_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS10025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1N74_RS10030	COG3546	catalase activity
C1N74_RS10050	COG1063	alcohol dehydrogenase
C1N74_RS10060	COG0300	oxidoreductase activity
C1N74_RS10075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1N74_RS10080	COG0583	DNA-binding transcription factor activity
C1N74_RS10090	COG1063	alcohol dehydrogenase
C1N74_RS10095	COG0457	Tetratricopeptide repeat
C1N74_RS10110	COG0395	ABC-type sugar transport system, permease component
C1N74_RS10115	COG1175	transmembrane transport
C1N74_RS10160	COG0488	(ABC) transporter
C1N74_RS10170	COG2501	S4 domain
C1N74_RS10180	COG2197	response regulator
C1N74_RS10190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1N74_RS10220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1N74_RS10230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1N74_RS10235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1N74_RS10290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1N74_RS10310	COG0587	DNA-directed DNA polymerase activity
C1N74_RS10350	COG4942	peptidase
C1N74_RS10370	COG1278	Cold shock
C1N74_RS10385	COG1061	Type III restriction enzyme res subunit
C1N74_RS10395	COG0745	RESPONSE REGULATOR receiver
C1N74_RS10400	COG2205	protein histidine kinase activity
C1N74_RS10410	COG0459	protein refolding
C1N74_RS10435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1N74_RS10465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1N74_RS10470	COG0318	PFAM AMP-dependent synthetase and ligase
C1N74_RS10475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1N74_RS10535	COG3842	ATPase activity
C1N74_RS10545	COG2910	NAD(P)H-binding
C1N74_RS10550	COG0058	SHG alpha-glucan phosphorylase activity
C1N74_RS10555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1N74_RS10560	COG0215	cysteine-tRNA ligase activity
C1N74_RS10565	COG0697	spore germination
C1N74_RS10575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1N74_RS10575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1N74_RS10580	COG1329	Transcriptional regulator
C1N74_RS10595	COG5002	protein histidine kinase activity
C1N74_RS10605	COG0588	phosphoglycerate mutase activity
C1N74_RS10625	COG0477	Major facilitator Superfamily
C1N74_RS10665	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C1N74_RS10675	COG0745	RESPONSE REGULATOR receiver
C1N74_RS10680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1N74_RS10700	COG0581	inorganic phosphate transmembrane transporter activity
C1N74_RS10705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1N74_RS10730	COG1595	DNA-templated transcription, initiation
C1N74_RS10745	COG0753	catalase activity
C1N74_RS10780	COG0384	phenazine biosynthesis protein PhzF
C1N74_RS10790	COG4565	transcriptional regulatory protein
C1N74_RS10795	COG3290	protein histidine kinase activity
C1N74_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS10840	COG2130	NADP-dependent
C1N74_RS10865	COG2188	Transcriptional regulator
C1N74_RS10875	COG0477	Major facilitator Superfamily
C1N74_RS10925	COG1136	(ABC) transporter
C1N74_RS10925	COG0577	efflux transmembrane transporter activity
C1N74_RS10930	COG1136	(ABC) transporter
C1N74_RS10930	COG0577	efflux transmembrane transporter activity
C1N74_RS10935	COG2815	serine threonine protein kinase
C1N74_RS10935	COG0515	serine threonine protein kinase
C1N74_RS10940	COG1335	isochorismatase
C1N74_RS10945	COG2409	Drug exporters of the RND superfamily
C1N74_RS10980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1N74_RS10985	COG2011	ABC-type metal ion transport system permease component
C1N74_RS11000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1N74_RS11005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1N74_RS11010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1N74_RS11010	COG1754	DNA topoisomerase type I activity
C1N74_RS11040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1N74_RS11060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1N74_RS11085	COG2186	Transcriptional regulator
C1N74_RS11090	COG1435	thymidine kinase activity
C1N74_RS11095	COG0579	oxidoreductase
C1N74_RS11115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1N74_RS11140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1N74_RS11155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1N74_RS11160	COG0196	riboflavin kinase activity
C1N74_RS11175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1N74_RS11185	COG0673	inositol 2-dehydrogenase activity
C1N74_RS11195	COG0673	inositol 2-dehydrogenase activity
C1N74_RS11200	COG1609	Transcriptional regulator
C1N74_RS11220	COG0673	inositol 2-dehydrogenase activity
C1N74_RS11230	COG0395	ABC-type sugar transport system, permease component
C1N74_RS11235	COG1175	transmembrane transport
C1N74_RS11255	COG1194	a g-specific adenine glycosylase
C1N74_RS11260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1N74_RS11265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1N74_RS11275	COG0195	Participates in both transcription termination and antitermination
C1N74_RS11295	COG0442	prolyl-tRNA aminoacylation
C1N74_RS11305	COG1595	DNA-templated transcription, initiation
C1N74_RS11310	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C1N74_RS11315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1N74_RS11325	COG0750	zinc metalloprotease
C1N74_RS11340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1N74_RS11350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1N74_RS11355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1N74_RS11360	COG0545	Peptidyl-prolyl cis-trans isomerase
C1N74_RS11370	COG0204	Acyl-transferase
C1N74_RS11370	COG0318	PFAM AMP-dependent synthetase and ligase
C1N74_RS11385	COG0686	Belongs to the AlaDH PNT family
C1N74_RS11395	COG0631	protein serine/threonine phosphatase activity
C1N74_RS11400	COG0667	Aldo Keto reductase
C1N74_RS11410	COG3022	response to hydroperoxide
C1N74_RS11420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1N74_RS11425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1N74_RS11430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1N74_RS11435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1N74_RS11440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1N74_RS11450	COG0356	it plays a direct role in the translocation of protons across the membrane
C1N74_RS11460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1N74_RS11465	COG0009	L-threonylcarbamoyladenylate synthase
C1N74_RS11470	COG2890	protein-(glutamine-N5) methyltransferase activity
C1N74_RS11480	COG1045	serine acetyltransferase
C1N74_RS11485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1N74_RS11495	COG0083	homoserine kinase activity
C1N74_RS11500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1N74_RS11505	COG0460	homoserine dehydrogenase
C1N74_RS11510	COG0019	diaminopimelate decarboxylase activity
C1N74_RS11530	COG0018	arginyl-trna synthetase
C1N74_RS11535	COG1305	Transglutaminase-like
C1N74_RS11615	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1N74_RS11670	COG1846	Transcriptional regulator
C1N74_RS11675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1N74_RS11680	COG2267	carboxylic ester hydrolase activity
C1N74_RS11700	COG2076	Multidrug Resistance protein
C1N74_RS11715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1N74_RS11730	COG1842	Phage shock protein A
C1N74_RS11755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1N74_RS11760	COG0596	Alpha beta hydrolase
C1N74_RS11760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1N74_RS11770	COG0601	transmembrane transport
C1N74_RS11780	COG0444	Belongs to the ABC transporter superfamily
C1N74_RS11800	COG0456	acetyltransferase
C1N74_RS11805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1N74_RS11835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1N74_RS11840	COG2814	Major facilitator Superfamily
C1N74_RS11860	COG1902	pentaerythritol trinitrate reductase activity
C1N74_RS11870	COG1253	flavin adenine dinucleotide binding
C1N74_RS11885	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1N74_RS11885	COG0567	Dehydrogenase, E1 component
C1N74_RS11895	COG1595	DNA-templated transcription, initiation
C1N74_RS11900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1N74_RS11905	COG1162	GTPase activity
C1N74_RS11960	COG0653	protein targeting
C1N74_RS11980	COG5401	PFAM Sporulation and spore germination
C1N74_RS11985	COG5000	phosphorelay sensor kinase activity
C1N74_RS11985	COG5002	protein histidine kinase activity
C1N74_RS11990	COG0745	RESPONSE REGULATOR receiver
C1N74_RS12010	COG0714	Associated with various cellular activities
C1N74_RS12020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1N74_RS12090	COG1216	Glycosyl transferase, family 2
C1N74_RS12120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1N74_RS12120	COG2755	lipolytic protein G-D-S-L family
C1N74_RS12155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1N74_RS12175	COG1088	dTDP-glucose 4,6-dehydratase activity
C1N74_RS12195	COG0463	Glycosyl transferase, family 2
C1N74_RS12225	COG1316	TRANSCRIPTIONal
C1N74_RS12230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1N74_RS12250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1N74_RS12270	COG2197	response regulator
C1N74_RS12275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1N74_RS12280	COG0424	maF-like protein
C1N74_RS12285	COG4770	biotin carboxylase activity
C1N74_RS12305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1N74_RS12310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1N74_RS12330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1N74_RS12335	COG2213	PTS system mannitol-specific
C1N74_RS12340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1N74_RS12345	COG0246	Mannitol dehydrogenase
C1N74_RS12360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1N74_RS12375	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1N74_RS12380	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1N74_RS12385	COG3845	ABC transporter
C1N74_RS12390	COG1744	ABC transporter substrate-binding protein PnrA-like
C1N74_RS12395	COG0662	Cupin 2, conserved barrel domain protein
C1N74_RS12395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C1N74_RS12400	COG2009	succinate dehydrogenase
C1N74_RS12430	COG0180	Tryptophanyl-tRNA synthetase
C1N74_RS12440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1N74_RS12445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1N74_RS12460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1N74_RS12460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1N74_RS12465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1N74_RS12475	COG0477	Major facilitator Superfamily
C1N74_RS12495	COG1131	(ABC) transporter
C1N74_RS12505	COG0800	Aldolase
C1N74_RS12520	COG0477	Major facilitator Superfamily
C1N74_RS12525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1N74_RS12540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1N74_RS12550	COG1132	(ABC) transporter
C1N74_RS12555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1N74_RS12575	COG0765	amino acid transport
C1N74_RS12585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1N74_RS12590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1N74_RS12600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1N74_RS12610	COG0277	FAD linked oxidase domain protein
C1N74_RS12620	COG1940	carbohydrate kinase activity
C1N74_RS12625	COG0395	ABC-type sugar transport system, permease component
C1N74_RS12630	COG1175	transmembrane transport
C1N74_RS12640	COG1940	carbohydrate kinase activity
C1N74_RS12660	COG2838	Isocitrate dehydrogenase
C1N74_RS12665	COG3458	cephalosporin-C deacetylase activity
C1N74_RS12675	COG1132	(ABC) transporter
C1N74_RS12680	COG1132	(ABC) transporter
C1N74_RS12750	COG1674	ftsk spoiiie
C1N74_RS12760	COG0138	bifunctional purine biosynthesis protein purh
C1N74_RS12775	COG2252	PERMEase
C1N74_RS12785	COG0045	succinate-CoA ligase (ADP-forming) activity
C1N74_RS12790	COG2197	response regulator
C1N74_RS12810	COG0318	PFAM AMP-dependent synthetase and ligase
C1N74_RS12820	COG1309	transcriptional regulator
C1N74_RS12825	COG1960	acyl-CoA dehydrogenase activity
C1N74_RS12835	COG1785	Belongs to the alkaline phosphatase family
C1N74_RS12845	COG1793	dna ligase
C1N74_RS12875	COG2197	response regulator
C1N74_RS12920	COG2207	Transcriptional regulator
C1N74_RS12940	COG2205	protein histidine kinase activity
C1N74_RS12945	COG0584	glycerophosphoryl diester phosphodiesterase
C1N74_RS12955	COG1940	carbohydrate kinase activity
C1N74_RS12995	COG1122	ATPase activity
C1N74_RS13000	COG1268	BioY protein
C1N74_RS13025	COG1160	GTP binding
C1N74_RS13030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1N74_RS13045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1N74_RS13050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1N74_RS13075	COG0494	nUDIX hydrolase
C1N74_RS13080	COG0504	CTP synthase activity
C1N74_RS13085	COG0497	DNA recombination
C1N74_RS13090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1N74_RS13105	COG0647	UMP catabolic process
C1N74_RS13130	COG0519	Catalyzes the synthesis of GMP from XMP
C1N74_RS13130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1N74_RS13145	COG0516	GMP reductase activity
C1N74_RS13150	COG0488	(ABC) transporter
C1N74_RS13205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1N74_RS13220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1N74_RS13235	COG0802	atpase or kinase
C1N74_RS13240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1N74_RS13245	COG0736	holo-[acyl-carrier-protein] synthase activity
C1N74_RS13250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1N74_RS13260	COG1072	(Pantothenic acid kinase))
C1N74_RS13265	COG0248	Ppx GppA phosphatase
C1N74_RS13280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1N74_RS13285	COG0297	glycogen (starch) synthase activity
C1N74_RS13320	COG0438	transferase activity, transferring glycosyl groups
C1N74_RS13325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1N74_RS13330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1N74_RS13340	COG0489	protein tyrosine kinase activity
C1N74_RS13355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1N74_RS13360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1N74_RS13365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1N74_RS13370	COG5002	protein histidine kinase activity
C1N74_RS13375	COG5002	protein histidine kinase activity
C1N74_RS13400	COG3237	CsbD-like
C1N74_RS13405	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C1N74_RS13410	COG1879	ABC-type sugar transport system periplasmic component
C1N74_RS13420	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1N74_RS13425	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1N74_RS13435	COG1609	Transcriptional regulator
C1N74_RS13445	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1N74_RS13450	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1N74_RS13470	COG0395	ABC-type sugar transport system, permease component
C1N74_RS13485	COG1609	Transcriptional regulator
C1N74_RS13540	COG0659	secondary active sulfate transmembrane transporter activity
C1N74_RS13545	COG0789	Transcriptional regulator
C1N74_RS13560	COG1309	transcriptional regulator
C1N74_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS13570	COG1846	Transcriptional regulator
C1N74_RS13590	COG2771	luxR family
C1N74_RS13595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1N74_RS13605	COG0489	protein tyrosine kinase activity
C1N74_RS13610	COG0489	protein tyrosine kinase activity
C1N74_RS13650	COG2244	polysaccharide biosynthetic process
C1N74_RS13670	COG0438	transferase activity, transferring glycosyl groups
C1N74_RS13685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1N74_RS13710	COG4989	oxidoreductase activity
C1N74_RS13725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1N74_RS13750	COG0489	protein tyrosine kinase activity
C1N74_RS13750	COG3206	protein involved in exopolysaccharide biosynthesis
C1N74_RS13770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1N74_RS13780	COG1607	acyl-coa hydrolase
C1N74_RS13800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1N74_RS13805	COG0651	ATP synthesis coupled electron transport
C1N74_RS13810	COG1006	Multisubunit Na H antiporter MnhC subunit
C1N74_RS13820	COG1320	monovalent cation:proton antiporter activity
C1N74_RS13845	COG0789	Transcriptional regulator
C1N74_RS13860	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1N74_RS13865	COG1121	(ABC) transporter
C1N74_RS13870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1N74_RS13905	COG0745	RESPONSE REGULATOR receiver
C1N74_RS13930	COG0101	tRNA pseudouridine synthase activity
C1N74_RS13940	COG2755	lipolytic protein G-D-S-L family
C1N74_RS13940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1N74_RS13950	COG0203	ribosomal protein L17
C1N74_RS13955	COG0202	RNA polymerase activity
C1N74_RS13960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1N74_RS13965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1N74_RS13975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1N74_RS13985	COG0024	Methionine aminopeptidase
C1N74_RS13990	COG0563	adenylate kinase activity
C1N74_RS14005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1N74_RS14010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1N74_RS14015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1N74_RS14020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1N74_RS14025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1N74_RS14030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1N74_RS14035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1N74_RS14040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1N74_RS14045	COG0255	Belongs to the universal ribosomal protein uL29 family
C1N74_RS14050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1N74_RS14055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1N74_RS14060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1N74_RS14065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1N74_RS14070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1N74_RS14075	COG0089	rRNA binding
C1N74_RS14080	COG0088	Forms part of the polypeptide exit tunnel
C1N74_RS14085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1N74_RS14090	COG0051	transcription antitermination factor activity, RNA binding
C1N74_RS14105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1N74_RS14110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1N74_RS14115	COG0049	tRNA binding
C1N74_RS14120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1N74_RS14155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1N74_RS14160	COG0085	RNA polymerase activity
C1N74_RS14175	COG1984	allophanate hydrolase subunit 2
C1N74_RS14180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1N74_RS14190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1N74_RS14195	COG0601	transmembrane transport
C1N74_RS14200	COG0747	negative chemotaxis
C1N74_RS14240	COG0577	efflux transmembrane transporter activity
C1N74_RS14240	COG1136	(ABC) transporter
C1N74_RS14245	COG2197	response regulator
C1N74_RS14250	COG4585	Histidine kinase
C1N74_RS14265	COG3958	Transketolase
C1N74_RS14270	COG3959	Transketolase, thiamine diphosphate binding domain
C1N74_RS14290	COG2378	regulation of single-species biofilm formation
C1N74_RS14310	COG0488	(ABC) transporter
C1N74_RS14315	COG1201	RNA secondary structure unwinding
C1N74_RS14320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1N74_RS14410	COG1295	ribonuclease BN
C1N74_RS14445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1N74_RS14450	COG1253	flavin adenine dinucleotide binding
C1N74_RS14470	COG1070	Carbohydrate kinase
C1N74_RS14475	COG2115	Belongs to the xylose isomerase family
C1N74_RS14495	COG2200	EAL domain
C1N74_RS14505	COG2084	Dehydrogenase
C1N74_RS14520	COG2186	Transcriptional regulator
C1N74_RS14560	COG4221	oxidoreductase activity
C1N74_RS14570	COG5297	Belongs to the glycosyl hydrolase family 6
C1N74_RS14570	COG3250	beta-galactosidase activity
C1N74_RS14590	COG0300	oxidoreductase activity
C1N74_RS14595	COG0039	L-malate dehydrogenase activity
C1N74_RS14600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1N74_RS14615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1N74_RS14620	COG2308	Evidence 4 Homologs of previously reported genes of
C1N74_RS14620	COG2307	Protein conserved in bacteria
C1N74_RS14630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1N74_RS14655	COG3655	Transcriptional regulator
C1N74_RS14690	COG1349	DNA-binding transcription factor activity
C1N74_RS14705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1N74_RS14715	COG0259	pyridoxamine-phosphate oxidase activity
C1N74_RS14725	COG1115	amino acid carrier protein
C1N74_RS14740	COG1609	Transcriptional regulator
C1N74_RS14755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1N74_RS14755	COG1263	PTS System
C1N74_RS14760	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1N74_RS14765	COG1737	Transcriptional regulator
C1N74_RS14790	COG1802	Transcriptional regulator
C1N74_RS14795	COG2423	ornithine cyclodeaminase activity
C1N74_RS14800	COG3938	Belongs to the proline racemase family
C1N74_RS14815	COG0006	proline dipeptidase activity
C1N74_RS14825	COG4172	Belongs to the ABC transporter superfamily
C1N74_RS14860	COG5398	heme oxygenase
C1N74_RS14865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1N74_RS14880	COG0776	regulation of translation
C1N74_RS14885	COG0657	acetylesterase activity
C1N74_RS14890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1N74_RS14895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1N74_RS14900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1N74_RS14910	COG2094	Belongs to the DNA glycosylase MPG family
C1N74_RS14925	COG0701	Predicted permease
C1N74_RS14935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1N74_RS14940	COG1121	(ABC) transporter
C1N74_RS14945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1N74_RS14955	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C1N74_RS14985	COG1516	flagellar protein fliS
C1N74_RS15000	COG1558	bacterial-type flagellum-dependent cell motility
C1N74_RS15010	COG1766	The M ring may be actively involved in energy transduction
C1N74_RS15015	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1N74_RS15025	COG1157	protein secretion by the type III secretion system
C1N74_RS15085	COG1338	Plays a role in the flagellum-specific transport system
C1N74_RS15100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1N74_RS15105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1N74_RS15110	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1N74_RS15115	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1N74_RS15120	COG2188	Transcriptional regulator
C1N74_RS15130	COG1129	ABC transporter
C1N74_RS15145	COG1830	Aldolase
C1N74_RS15150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1N74_RS15160	COG3347	Dehydrogenase
C1N74_RS15160	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS15175	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1N74_RS15180	COG0022	dehydrogenase e1 component
C1N74_RS15195	COG0366	Alpha amylase catalytic
C1N74_RS15200	COG1609	Transcriptional regulator
C1N74_RS15205	COG0747	negative chemotaxis
C1N74_RS15210	COG0601	transmembrane transport
C1N74_RS15235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1N74_RS15240	COG1950	PFAM Membrane protein of
C1N74_RS15255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1N74_RS15260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1N74_RS15275	COG2130	NADP-dependent
C1N74_RS15305	COG1063	alcohol dehydrogenase
C1N74_RS15315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1N74_RS15325	COG0395	ABC-type sugar transport system, permease component
C1N74_RS15340	COG0531	amino acid
C1N74_RS15360	COG1301	dicarboxylic acid transport
C1N74_RS15365	COG2186	Transcriptional regulator
C1N74_RS15385	COG3340	Belongs to the peptidase S51 family
C1N74_RS15395	COG0395	ABC-type sugar transport system, permease component
C1N74_RS15400	COG1175	transmembrane transport
C1N74_RS15415	COG1653	transport
C1N74_RS15425	COG3250	beta-galactosidase activity
C1N74_RS15455	COG2140	Oxalate decarboxylase
C1N74_RS15460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1N74_RS15470	COG1070	Carbohydrate kinase
C1N74_RS15475	COG4221	oxidoreductase activity
C1N74_RS15480	COG0800	Aldolase
C1N74_RS15495	COG4172	Belongs to the ABC transporter superfamily
C1N74_RS15500	COG0444	Belongs to the ABC transporter superfamily
C1N74_RS15510	COG0601	transmembrane transport
C1N74_RS15515	COG4166	transmembrane transport
C1N74_RS15535	COG3046	protein related to deoxyribodipyrimidine photolyase
C1N74_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS15565	COG0577	efflux transmembrane transporter activity
C1N74_RS15565	COG1136	(ABC) transporter
C1N74_RS15600	COG0305	Participates in initiation and elongation during chromosome replication
C1N74_RS15615	COG0359	binds to the 23S rRNA
C1N74_RS15620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1N74_RS15630	COG0360	Binds together with S18 to 16S ribosomal RNA
C1N74_RS15645	COG1902	pentaerythritol trinitrate reductase activity
C1N74_RS15650	COG0477	Major facilitator Superfamily
C1N74_RS15660	COG1335	isochorismatase
C1N74_RS15705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1N74_RS15725	COG1396	sequence-specific DNA binding
C1N74_RS15730	COG0300	oxidoreductase activity
C1N74_RS15735	COG1028	Short-chain dehydrogenase reductase Sdr
C1N74_RS15745	COG0395	ABC-type sugar transport system, permease component
C1N74_RS15750	COG1175	transmembrane transport
C1N74_RS15760	COG3250	beta-galactosidase activity
C1N74_RS15765	COG1609	Transcriptional regulator
C1N74_RS15775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1N74_RS15815	COG1609	Transcriptional regulator
C1N74_RS15820	COG2217	Heavy metal translocating P-type atpase
C1N74_RS15830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1N74_RS15835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1N74_RS15840	COG0798	PFAM Bile acid sodium symporter
C1N74_RS15845	COG0492	ferredoxin-NADP+ reductase activity
C1N74_RS15870	COG1012	belongs to the aldehyde dehydrogenase family
C1N74_RS15875	COG3507	Belongs to the glycosyl hydrolase 43 family
C1N74_RS15910	COG2890	protein-(glutamine-N5) methyltransferase activity
C1N74_RS15925	COG0492	ferredoxin-NADP+ reductase activity
C1N74_RS15930	COG3118	belongs to the thioredoxin family
C1N74_RS15945	COG1192	Involved in chromosome partitioning
C1N74_RS15950	COG0357	Ribosomal RNA small subunit methyltransferase G
C1N74_RS15960	COG0706	membrane insertase activity
C1N74_RS15965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1N74_RS15970	COG0594	ribonuclease P activity
C1N74_RS15975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1N74_RS16085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1N74_RS16205	COG0438	transferase activity, transferring glycosyl groups
C1N74_RS16240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1N74_RS16245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1N74_RS16265	COG0789	Transcriptional regulator
C1N74_RS16290	COG1733	regulation of RNA biosynthetic process
C1N74_RS16315	COG2847	Copper chaperone PCu(A)C