locus-tag	class	description
E4K62_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4K62_RS00010	COG0592	DNA-directed DNA polymerase activity
E4K62_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4K62_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E4K62_RS00025	COG0187	DNA topoisomerase II activity
E4K62_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4K62_RS00085	COG0705	Rhomboid family
E4K62_RS00095	COG3764	Sortase (surface protein transpeptidase)
E4K62_RS00105	COG2815	serine threonine protein kinase
E4K62_RS00105	COG0515	serine threonine protein kinase
E4K62_RS00110	COG0515	serine threonine protein kinase
E4K62_RS00115	COG0768	penicillin binding
E4K62_RS00130	COG1716	ATPase activity
E4K62_RS00135	COG1716	ATPase activity
E4K62_RS00165	COG1278	Cold shock
E4K62_RS00170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4K62_RS00180	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E4K62_RS00185	COG0159	tryptophan synthase activity
E4K62_RS00190	COG2188	Transcriptional regulator
E4K62_RS00195	COG1129	ABC transporter
E4K62_RS00200	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS00215	COG0738	Major facilitator superfamily
E4K62_RS00220	COG1609	Transcriptional regulator
E4K62_RS00225	COG2111	Na H antiporter
E4K62_RS00225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4K62_RS00230	COG1006	Multisubunit Na H antiporter MnhC subunit
E4K62_RS00235	COG0651	ATP synthesis coupled electron transport
E4K62_RS00245	COG2212	antiporter activity
E4K62_RS00255	COG1511	domain protein
E4K62_RS00270	COG1879	ABC-type sugar transport system periplasmic component
E4K62_RS00280	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS00295	COG1609	Transcriptional regulator
E4K62_RS00310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4K62_RS00320	COG0628	permease
E4K62_RS00325	COG1605	Chorismate mutase
E4K62_RS00325	COG0287	Prephenate dehydrogenase
E4K62_RS00335	COG1131	(ABC) transporter
E4K62_RS00365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4K62_RS00415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4K62_RS00450	COG1609	Transcriptional regulator
E4K62_RS00455	COG0366	Alpha amylase catalytic
E4K62_RS00460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4K62_RS00465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K62_RS00480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K62_RS00495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4K62_RS00505	COG0402	S-adenosylhomocysteine deaminase activity
E4K62_RS00515	COG1116	anion transmembrane transporter activity
E4K62_RS00525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS00540	COG2268	Band 7 protein
E4K62_RS00545	COG2080	2 iron, 2 sulfur cluster binding
E4K62_RS00545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4K62_RS00555	COG0640	Transcriptional regulator
E4K62_RS00565	COG2814	Major facilitator Superfamily
E4K62_RS00570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4K62_RS00570	COG3608	succinylglutamate desuccinylase aspartoacylase
E4K62_RS00580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4K62_RS00585	COG0047	phosphoribosylformylglycinamidine synthase activity
E4K62_RS00590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4K62_RS00610	COG2723	6-phospho-beta-galactosidase activity
E4K62_RS00620	COG2233	PERMEase
E4K62_RS00625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4K62_RS00630	COG0151	Belongs to the GarS family
E4K62_RS00650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4K62_RS00670	COG1695	Transcriptional regulator
E4K62_RS00695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4K62_RS00700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4K62_RS00715	COG0513	Belongs to the DEAD box helicase family
E4K62_RS00720	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4K62_RS00735	COG1960	acyl-CoA dehydrogenase activity
E4K62_RS00740	COG1316	TRANSCRIPTIONal
E4K62_RS00745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4K62_RS00750	COG1122	ATPase activity
E4K62_RS00775	COG4941	Belongs to the sigma-70 factor family
E4K62_RS00790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4K62_RS00820	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS00835	COG0519	Catalyzes the synthesis of GMP from XMP
E4K62_RS00855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4K62_RS00860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4K62_RS00860	COG2755	lipolytic protein G-D-S-L family
E4K62_RS00870	COG0714	Associated with various cellular activities
E4K62_RS00890	COG0631	protein serine/threonine phosphatase activity
E4K62_RS00915	COG2197	response regulator
E4K62_RS00930	COG0025	NhaP-type Na H and K H
E4K62_RS00955	COG0463	Glycosyl transferase, family 2
E4K62_RS00965	COG3655	Transcriptional regulator
E4K62_RS00970	COG3795	YCII-related domain
E4K62_RS00975	COG4941	Belongs to the sigma-70 factor family
E4K62_RS00990	COG1506	peptidase
E4K62_RS00990	COG0823	Involved in the tonB-independent uptake of proteins
E4K62_RS01020	COG0251	oxidation-reduction process
E4K62_RS01035	COG1396	sequence-specific DNA binding
E4K62_RS01035	COG1917	Cupin 2, conserved barrel domain protein
E4K62_RS01045	COG1280	lysine exporter protein (LysE YggA)
E4K62_RS01065	COG0259	pyridoxamine-phosphate oxidase activity
E4K62_RS01140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4K62_RS01145	COG0037	tRNA processing
E4K62_RS01155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4K62_RS01160	COG0302	gtp cyclohydrolase
E4K62_RS01170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4K62_RS01175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4K62_RS01200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4K62_RS01205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4K62_RS01220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4K62_RS01235	COG2945	thiolester hydrolase activity
E4K62_RS01235	COG0596	Alpha beta hydrolase
E4K62_RS01240	COG3655	Transcriptional regulator
E4K62_RS01275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4K62_RS01290	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4K62_RS01295	COG0673	inositol 2-dehydrogenase activity
E4K62_RS01315	COG3119	arylsulfatase activity
E4K62_RS01320	COG1609	Transcriptional regulator
E4K62_RS01355	COG3395	kinase activity
E4K62_RS01360	COG1175	transmembrane transport
E4K62_RS01365	COG0395	ABC-type sugar transport system, permease component
E4K62_RS01385	COG0039	L-malate dehydrogenase activity
E4K62_RS01395	COG4974	Belongs to the 'phage' integrase family
E4K62_RS01405	COG1192	Involved in chromosome partitioning
E4K62_RS01440	COG2826	transposase and inactivated derivatives, IS30 family
E4K62_RS01485	COG2894	cell division
E4K62_RS01510	COG0739	heme binding
E4K62_RS01555	COG0656	L-ascorbic acid biosynthetic process
E4K62_RS01570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4K62_RS01575	COG0085	RNA polymerase activity
E4K62_RS01615	COG0659	secondary active sulfate transmembrane transporter activity
E4K62_RS01665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4K62_RS01670	COG0367	asparagine synthase
E4K62_RS01675	COG1309	transcriptional regulator
E4K62_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS01695	COG1733	regulation of RNA biosynthetic process
E4K62_RS01700	COG1309	transcriptional regulator
E4K62_RS01705	COG0477	Major facilitator Superfamily
E4K62_RS01720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K62_RS01760	COG2132	Multicopper oxidase
E4K62_RS01785	COG3281	Trehalose synthase
E4K62_RS01815	COG0640	Transcriptional regulator
E4K62_RS01840	COG0667	Aldo Keto reductase
E4K62_RS01855	COG1131	(ABC) transporter
E4K62_RS01880	COG3546	catalase activity
E4K62_RS01885	COG1737	Transcriptional regulator
E4K62_RS01895	COG0601	transmembrane transport
E4K62_RS01900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS01905	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4K62_RS01910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4K62_RS01915	COG4948	Mandelate Racemase Muconate Lactonizing
E4K62_RS01930	COG1607	acyl-coa hydrolase
E4K62_RS01935	COG0640	Transcriptional regulator
E4K62_RS01960	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K62_RS01970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K62_RS01980	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K62_RS02000	COG0477	Major facilitator Superfamily
E4K62_RS02010	COG1733	regulation of RNA biosynthetic process
E4K62_RS02040	COG1280	lysine exporter protein (LysE YggA)
E4K62_RS02045	COG2132	Multicopper oxidase
E4K62_RS02060	COG4585	Histidine kinase
E4K62_RS02065	COG2197	response regulator
E4K62_RS02145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4K62_RS02150	COG2011	ABC-type metal ion transport system permease component
E4K62_RS02155	COG0436	Aminotransferase
E4K62_RS02205	COG2115	Belongs to the xylose isomerase family
E4K62_RS02210	COG1070	Carbohydrate kinase
E4K62_RS02230	COG0395	ABC-type sugar transport system, permease component
E4K62_RS02235	COG3534	alpha-L-arabinofuranosidase
E4K62_RS02245	COG2382	esterase
E4K62_RS02255	COG0395	ABC-type sugar transport system, permease component
E4K62_RS02260	COG1175	transmembrane transport
E4K62_RS02280	COG2409	Drug exporters of the RND superfamily
E4K62_RS02285	COG2357	RelA SpoT domain protein
E4K62_RS02295	COG1253	flavin adenine dinucleotide binding
E4K62_RS02335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K62_RS02335	COG0519	Catalyzes the synthesis of GMP from XMP
E4K62_RS02375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K62_RS02390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4K62_RS02395	COG1201	RNA secondary structure unwinding
E4K62_RS02405	COG0488	(ABC) transporter
E4K62_RS02420	COG2376	Dihydroxyacetone kinase
E4K62_RS02425	COG0698	ribose 5-phosphate isomerase
E4K62_RS02430	COG0149	triose-phosphate isomerase activity
E4K62_RS02445	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K62_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS02455	COG2271	Major facilitator Superfamily
E4K62_RS02490	COG2197	response regulator
E4K62_RS02495	COG4585	Histidine kinase
E4K62_RS02505	COG4585	Histidine kinase
E4K62_RS02510	COG2197	response regulator
E4K62_RS02515	COG0577	efflux transmembrane transporter activity
E4K62_RS02515	COG1136	(ABC) transporter
E4K62_RS02550	COG0747	negative chemotaxis
E4K62_RS02555	COG0601	transmembrane transport
E4K62_RS02560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS02565	COG4172	Belongs to the ABC transporter superfamily
E4K62_RS02570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4K62_RS02575	COG1984	allophanate hydrolase subunit 2
E4K62_RS02580	COG0085	RNA polymerase activity
E4K62_RS02585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4K62_RS02620	COG0714	Associated with various cellular activities
E4K62_RS02645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4K62_RS02650	COG0049	tRNA binding
E4K62_RS02655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4K62_RS02660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4K62_RS02680	COG0051	transcription antitermination factor activity, RNA binding
E4K62_RS02685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4K62_RS02690	COG0088	Forms part of the polypeptide exit tunnel
E4K62_RS02695	COG0089	rRNA binding
E4K62_RS02700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4K62_RS02705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4K62_RS02710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4K62_RS02715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4K62_RS02720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4K62_RS02725	COG0255	Belongs to the universal ribosomal protein uL29 family
E4K62_RS02730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4K62_RS02735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4K62_RS02740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4K62_RS02745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4K62_RS02750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4K62_RS02755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4K62_RS02760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4K62_RS02765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4K62_RS02770	COG1841	ribosomal large subunit assembly
E4K62_RS02775	COG0200	Binds to the 23S rRNA
E4K62_RS02785	COG0563	adenylate kinase activity
E4K62_RS02790	COG0024	Methionine aminopeptidase
E4K62_RS02805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4K62_RS02815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4K62_RS02820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4K62_RS02825	COG0202	RNA polymerase activity
E4K62_RS02830	COG0203	ribosomal protein L17
E4K62_RS02835	COG0456	acetyltransferase
E4K62_RS02835	COG0454	-acetyltransferase
E4K62_RS02840	COG2755	lipolytic protein G-D-S-L family
E4K62_RS02840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4K62_RS02845	COG0101	tRNA pseudouridine synthase activity
E4K62_RS02875	COG5002	protein histidine kinase activity
E4K62_RS02890	COG0745	RESPONSE REGULATOR receiver
E4K62_RS02905	COG1846	Transcriptional regulator
E4K62_RS02940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS02945	COG0598	Magnesium transport protein CorA
E4K62_RS02950	COG4989	oxidoreductase activity
E4K62_RS02955	COG1881	PFAM PEBP family protein
E4K62_RS02980	COG1175	transmembrane transport
E4K62_RS02985	COG0395	ABC-type sugar transport system, permease component
E4K62_RS03005	COG4821	SIS domain
E4K62_RS03030	COG4172	Belongs to the ABC transporter superfamily
E4K62_RS03035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS03040	COG0601	transmembrane transport
E4K62_RS03045	COG0747	negative chemotaxis
E4K62_RS03055	COG1396	sequence-specific DNA binding
E4K62_RS03090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4K62_RS03100	COG0438	transferase activity, transferring glycosyl groups
E4K62_RS03120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4K62_RS03140	COG0489	protein tyrosine kinase activity
E4K62_RS03145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K62_RS03170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4K62_RS03175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4K62_RS03180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4K62_RS03195	COG0248	Ppx GppA phosphatase
E4K62_RS03200	COG1072	(Pantothenic acid kinase))
E4K62_RS03230	COG0673	inositol 2-dehydrogenase activity
E4K62_RS03250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4K62_RS03255	COG2244	polysaccharide biosynthetic process
E4K62_RS03265	COG0438	transferase activity, transferring glycosyl groups
E4K62_RS03325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4K62_RS03340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4K62_RS03345	COG2843	Capsule synthesis protein
E4K62_RS03350	COG2079	MmgE PrpD family protein
E4K62_RS03360	COG0444	Belongs to the ABC transporter superfamily
E4K62_RS03365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS03370	COG0601	transmembrane transport
E4K62_RS03390	COG0736	holo-[acyl-carrier-protein] synthase activity
E4K62_RS03395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4K62_RS03400	COG0802	atpase or kinase
E4K62_RS03410	COG0456	acetyltransferase
E4K62_RS03415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4K62_RS03465	COG0443	Heat shock 70 kDa protein
E4K62_RS03470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4K62_RS03510	COG0516	GMP reductase activity
E4K62_RS03525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K62_RS03525	COG0519	Catalyzes the synthesis of GMP from XMP
E4K62_RS03530	COG2885	chlorophyll binding
E4K62_RS03540	COG0740	serine-type endopeptidase activity
E4K62_RS03545	COG0740	serine-type endopeptidase activity
E4K62_RS03560	COG3285	dna ligase
E4K62_RS03560	COG1793	dna ligase
E4K62_RS03575	COG0584	glycerophosphoryl diester phosphodiesterase
E4K62_RS03580	COG1131	(ABC) transporter
E4K62_RS03615	COG1063	alcohol dehydrogenase
E4K62_RS03640	COG2188	Transcriptional regulator
E4K62_RS03645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K62_RS03660	COG3718	enzyme involved in inositol metabolism
E4K62_RS03665	COG3962	Belongs to the TPP enzyme family
E4K62_RS03680	COG1082	Xylose isomerase domain protein TIM barrel
E4K62_RS03685	COG2814	Major facilitator Superfamily
E4K62_RS03690	COG0673	inositol 2-dehydrogenase activity
E4K62_RS03700	COG0673	inositol 2-dehydrogenase activity
E4K62_RS03705	COG1609	Transcriptional regulator
E4K62_RS03710	COG1942	4-Oxalocrotonate Tautomerase
E4K62_RS03715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4K62_RS03720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4K62_RS03740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4K62_RS03755	COG1414	Transcriptional regulator
E4K62_RS03760	COG0006	proline dipeptidase activity
E4K62_RS03805	COG4821	SIS domain
E4K62_RS03810	COG1653	transport
E4K62_RS03815	COG1175	transmembrane transport
E4K62_RS03820	COG0395	ABC-type sugar transport system, permease component
E4K62_RS03830	COG4585	Histidine kinase
E4K62_RS03840	COG1609	Transcriptional regulator
E4K62_RS03880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K62_RS03885	COG2301	Belongs to the HpcH HpaI aldolase family
E4K62_RS03945	COG3285	dna ligase
E4K62_RS03945	COG1793	dna ligase
E4K62_RS03950	COG1793	dna ligase
E4K62_RS03965	COG0628	permease
E4K62_RS03975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E4K62_RS03985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4K62_RS03995	COG4585	Histidine kinase
E4K62_RS04000	COG2197	response regulator
E4K62_RS04005	COG0045	succinate-CoA ligase (ADP-forming) activity
E4K62_RS04015	COG2252	PERMEase
E4K62_RS04035	COG0138	bifunctional purine biosynthesis protein purh
E4K62_RS04060	COG1674	ftsk spoiiie
E4K62_RS04110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K62_RS04120	COG1653	transport
E4K62_RS04125	COG1175	transmembrane transport
E4K62_RS04130	COG0395	ABC-type sugar transport system, permease component
E4K62_RS04135	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
E4K62_RS04150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4K62_RS04150	COG2169	Transcriptional regulator
E4K62_RS04155	COG1132	(ABC) transporter
E4K62_RS04160	COG1132	(ABC) transporter
E4K62_RS04175	COG2838	Isocitrate dehydrogenase
E4K62_RS04180	COG3458	cephalosporin-C deacetylase activity
E4K62_RS04195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4K62_RS04195	COG1940	carbohydrate kinase activity
E4K62_RS04205	COG1175	transmembrane transport
E4K62_RS04210	COG3833	ABC-type maltose transport systems, permease component
E4K62_RS04215	COG1846	Transcriptional regulator
E4K62_RS04215	COG1940	carbohydrate kinase activity
E4K62_RS04220	COG0363	glucosamine-6-phosphate deaminase activity
E4K62_RS04225	COG0277	FAD linked oxidase domain protein
E4K62_RS04235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4K62_RS04245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4K62_RS04250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4K62_RS04260	COG1305	Transglutaminase-like
E4K62_RS04265	COG0402	S-adenosylhomocysteine deaminase activity
E4K62_RS04315	COG2508	Transcriptional regulator
E4K62_RS04335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K62_RS04345	COG3971	2-oxopent-4-enoate hydratase activity
E4K62_RS04355	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS04370	COG0477	Major facilitator Superfamily
E4K62_RS04385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K62_RS04410	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K62_RS04430	COG0129	dihydroxy-acid dehydratase activity
E4K62_RS04445	COG2084	Dehydrogenase
E4K62_RS04455	COG0028	Belongs to the TPP enzyme family
E4K62_RS04480	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K62_RS04490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4K62_RS04500	COG2814	Major facilitator Superfamily
E4K62_RS04530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E4K62_RS04535	COG1132	(ABC) transporter
E4K62_RS04560	COG0477	Major facilitator Superfamily
E4K62_RS04570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4K62_RS04575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4K62_RS04575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4K62_RS04590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4K62_RS04600	COG0180	Tryptophanyl-tRNA synthetase
E4K62_RS04615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4K62_RS04630	COG2009	succinate dehydrogenase
E4K62_RS04640	COG1744	ABC transporter substrate-binding protein PnrA-like
E4K62_RS04645	COG3845	ABC transporter
E4K62_RS04650	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS04655	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS04685	COG0246	Mannitol dehydrogenase
E4K62_RS04690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K62_RS04695	COG2213	PTS system mannitol-specific
E4K62_RS04700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K62_RS04725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4K62_RS04740	COG4770	biotin carboxylase activity
E4K62_RS04745	COG0424	maF-like protein
E4K62_RS04750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4K62_RS04775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4K62_RS04800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4K62_RS04815	COG2247	cell wall binding repeat
E4K62_RS04815	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4K62_RS04875	COG0438	transferase activity, transferring glycosyl groups
E4K62_RS04890	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4K62_RS04900	COG1088	dTDP-glucose 4,6-dehydratase activity
E4K62_RS04910	COG0406	alpha-ribazole phosphatase activity
E4K62_RS04915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4K62_RS04920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4K62_RS05000	COG0463	Glycosyl transferase, family 2
E4K62_RS05005	COG1216	Glycosyl transferase, family 2
E4K62_RS05060	COG0735	belongs to the Fur family
E4K62_RS05065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4K62_RS05075	COG0714	Associated with various cellular activities
E4K62_RS05095	COG0745	RESPONSE REGULATOR receiver
E4K62_RS05100	COG5000	phosphorelay sensor kinase activity
E4K62_RS05100	COG5002	protein histidine kinase activity
E4K62_RS05105	COG5401	PFAM Sporulation and spore germination
E4K62_RS05130	COG1136	(ABC) transporter
E4K62_RS05130	COG0577	efflux transmembrane transporter activity
E4K62_RS05140	COG0653	protein targeting
E4K62_RS05205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4K62_RS05210	COG1595	DNA-templated transcription, initiation
E4K62_RS05220	COG4552	Acetyltransferase involved in intracellular survival and related
E4K62_RS05225	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K62_RS05225	COG0567	Dehydrogenase, E1 component
E4K62_RS05240	COG1253	flavin adenine dinucleotide binding
E4K62_RS05250	COG1902	pentaerythritol trinitrate reductase activity
E4K62_RS05270	COG2814	Major facilitator Superfamily
E4K62_RS05275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K62_RS05295	COG2814	Major facilitator Superfamily
E4K62_RS05300	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4K62_RS05305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4K62_RS05330	COG0444	Belongs to the ABC transporter superfamily
E4K62_RS05335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS05340	COG0601	transmembrane transport
E4K62_RS05345	COG0747	negative chemotaxis
E4K62_RS05350	COG0596	Alpha beta hydrolase
E4K62_RS05350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K62_RS05355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4K62_RS05360	COG2365	Tyrosine phosphatase family
E4K62_RS05380	COG1842	Phage shock protein A
E4K62_RS05395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4K62_RS05425	COG3226	Transcriptional regulator
E4K62_RS05445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4K62_RS05470	COG2124	cytochrome p450
E4K62_RS05480	COG0596	Alpha beta hydrolase
E4K62_RS05490	COG2066	Belongs to the glutaminase family
E4K62_RS05495	COG1295	ribonuclease BN
E4K62_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS05580	COG3973	AAA domain
E4K62_RS05615	COG1305	Transglutaminase-like
E4K62_RS05620	COG0018	arginyl-trna synthetase
E4K62_RS05635	COG0460	homoserine dehydrogenase
E4K62_RS05645	COG0083	homoserine kinase activity
E4K62_RS05655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4K62_RS05660	COG0154	amidase activity
E4K62_RS05665	COG1045	serine acetyltransferase
E4K62_RS05675	COG2890	protein-(glutamine-N5) methyltransferase activity
E4K62_RS05680	COG0009	L-threonylcarbamoyladenylate synthase
E4K62_RS05685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4K62_RS05695	COG0356	it plays a direct role in the translocation of protons across the membrane
E4K62_RS05700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4K62_RS05705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4K62_RS05710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4K62_RS05715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4K62_RS05720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4K62_RS05725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4K62_RS05730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4K62_RS05735	COG3022	response to hydroperoxide
E4K62_RS05745	COG0667	Aldo Keto reductase
E4K62_RS05750	COG0631	protein serine/threonine phosphatase activity
E4K62_RS05765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4K62_RS05770	COG0686	Belongs to the AlaDH PNT family
E4K62_RS05785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4K62_RS05790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4K62_RS05795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4K62_RS05805	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4K62_RS05805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K62_RS05805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K62_RS05810	COG1461	Dihydroxyacetone kinase
E4K62_RS05815	COG2376	Dihydroxyacetone kinase
E4K62_RS05830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4K62_RS05835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4K62_RS05840	COG0531	amino acid
E4K62_RS05845	COG0076	glutamate decarboxylase activity
E4K62_RS05850	COG0750	zinc metalloprotease
E4K62_RS05865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4K62_RS05870	COG3135	benzoate transporter
E4K62_RS05880	COG0442	prolyl-tRNA aminoacylation
E4K62_RS05885	COG0656	L-ascorbic acid biosynthetic process
E4K62_RS05910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4K62_RS05915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4K62_RS05920	COG1194	a g-specific adenine glycosylase
E4K62_RS05930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4K62_RS05945	COG0196	riboflavin kinase activity
E4K62_RS05960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4K62_RS06005	COG0545	Peptidyl-prolyl cis-trans isomerase
E4K62_RS06015	COG0697	spore germination
E4K62_RS06020	COG0477	Major facilitator Superfamily
E4K62_RS06025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4K62_RS06035	COG3594	Acyltransferase
E4K62_RS06075	COG1185	polyribonucleotide nucleotidyltransferase activity
E4K62_RS06080	COG0667	Aldo Keto reductase
E4K62_RS06105	COG1090	epimerase
E4K62_RS06110	COG1764	response to oxidative stress
E4K62_RS06125	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4K62_RS06130	COG4221	oxidoreductase activity
E4K62_RS06135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4K62_RS06140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4K62_RS06150	COG1674	ftsk spoiiie
E4K62_RS06160	COG1546	Belongs to the CinA family
E4K62_RS06160	COG1058	Belongs to the CinA family
E4K62_RS06165	COG1396	sequence-specific DNA binding
E4K62_RS06175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4K62_RS06180	COG2137	regulation of response to DNA damage stimulus
E4K62_RS06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4K62_RS06205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4K62_RS06210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4K62_RS06215	COG2813	Specifically methylates the guanine in position
E4K62_RS06220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4K62_RS06235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4K62_RS06245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4K62_RS06250	COG0131	Imidazoleglycerol-phosphate dehydratase
E4K62_RS06255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4K62_RS06260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4K62_RS06275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4K62_RS06280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4K62_RS06285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4K62_RS06290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K62_RS06295	COG1126	abc transporter atp-binding protein
E4K62_RS06305	COG0765	amino acid transport
E4K62_RS06310	COG0765	amino acid transport
E4K62_RS06315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4K62_RS06320	COG0072	phenylalanine-tRNA ligase activity
E4K62_RS06320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K62_RS06330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4K62_RS06335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4K62_RS06340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4K62_RS06345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4K62_RS06350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4K62_RS06360	COG0165	Argininosuccinate lyase
E4K62_RS06375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4K62_RS06405	COG0647	UMP catabolic process
E4K62_RS06415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4K62_RS06420	COG0497	DNA recombination
E4K62_RS06430	COG0504	CTP synthase activity
E4K62_RS06435	COG0494	nUDIX hydrolase
E4K62_RS06450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4K62_RS06455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4K62_RS06465	COG0287	Prephenate dehydrogenase
E4K62_RS06470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4K62_RS06475	COG1160	GTP binding
E4K62_RS06530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4K62_RS06545	COG0640	Transcriptional regulator
E4K62_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS06575	COG0445	tRNA wobble uridine modification
E4K62_RS06590	COG1609	Transcriptional regulator
E4K62_RS06610	COG0395	ABC-type sugar transport system, permease component
E4K62_RS06630	COG1131	(ABC) transporter
E4K62_RS06655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4K62_RS06660	COG1595	DNA-templated transcription, initiation
E4K62_RS06725	COG1733	regulation of RNA biosynthetic process
E4K62_RS06755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K62_RS06755	COG0574	Belongs to the PEP-utilizing enzyme family
E4K62_RS06810	COG0667	Aldo Keto reductase
E4K62_RS06820	COG2197	response regulator
E4K62_RS06825	COG4585	Histidine kinase
E4K62_RS06845	COG0463	Glycosyl transferase, family 2
E4K62_RS06865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4K62_RS06875	COG0058	SHG alpha-glucan phosphorylase activity
E4K62_RS06900	COG1716	ATPase activity
E4K62_RS06915	COG1192	Involved in chromosome partitioning
E4K62_RS06920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E4K62_RS06940	COG1940	carbohydrate kinase activity
E4K62_RS06945	COG0204	Acyl-transferase
E4K62_RS06950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E4K62_RS06955	COG0515	serine threonine protein kinase
E4K62_RS06955	COG2815	serine threonine protein kinase
E4K62_RS06970	COG0142	geranyltranstransferase activity
E4K62_RS06980	COG2001	Belongs to the MraZ family
E4K62_RS06985	COG0275	rRNA processing
E4K62_RS06995	COG0768	penicillin binding
E4K62_RS07005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4K62_RS07010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4K62_RS07020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4K62_RS07025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4K62_RS07035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4K62_RS07040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4K62_RS07045	COG1799	cell septum assembly
E4K62_RS07060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4K62_RS07080	COG0587	DNA-directed DNA polymerase activity
E4K62_RS07090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4K62_RS07095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4K62_RS07100	COG0167	dihydroorotate dehydrogenase activity
E4K62_RS07120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4K62_RS07125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4K62_RS07155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4K62_RS07160	COG0723	plastoquinol--plastocyanin reductase activity
E4K62_RS07165	COG2010	Cytochrome c
E4K62_RS07170	COG1845	cytochrome c oxidase, subunit III
E4K62_RS07175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4K62_RS07180	COG1796	DNA polymerase
E4K62_RS07180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4K62_RS07185	COG2807	transmembrane transport
E4K62_RS07190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4K62_RS07225	COG3012	SEC-C Motif Domain Protein
E4K62_RS07240	COG4129	membrane
E4K62_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS07255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4K62_RS07310	COG1215	transferase activity, transferring glycosyl groups
E4K62_RS07325	COG0733	neurotransmitter:sodium symporter activity
E4K62_RS07335	COG2205	protein histidine kinase activity
E4K62_RS07340	COG0745	RESPONSE REGULATOR receiver
E4K62_RS07370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K62_RS07375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K62_RS07400	COG0028	Belongs to the TPP enzyme family
E4K62_RS07415	COG4607	ABC-type enterochelin transport system periplasmic component
E4K62_RS07420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4K62_RS07425	COG4605	iron ion homeostasis
E4K62_RS07430	COG4604	ABC transporter, ATP-binding protein
E4K62_RS07450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4K62_RS07455	COG0166	Belongs to the GPI family
E4K62_RS07495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4K62_RS07535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K62_RS07555	COG0444	Belongs to the ABC transporter superfamily
E4K62_RS07580	COG4948	Mandelate Racemase Muconate Lactonizing
E4K62_RS07590	COG1397	ADP-ribosylglycohydrolase
E4K62_RS07615	COG0539	negative regulation of cytoplasmic translation
E4K62_RS07640	COG2814	Major facilitator Superfamily
E4K62_RS07665	COG5002	protein histidine kinase activity
E4K62_RS07680	COG0237	dephospho-CoA kinase activity
E4K62_RS07685	COG0556	nucleotide-excision repair
E4K62_RS07695	COG1846	Transcriptional regulator
E4K62_RS07705	COG0322	excinuclease ABC activity
E4K62_RS07710	COG1660	Displays ATPase and GTPase activities
E4K62_RS07715	COG1481	regulation of sporulation
E4K62_RS07720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4K62_RS07730	COG0126	phosphoglycerate kinase activity
E4K62_RS07735	COG0149	triose-phosphate isomerase activity
E4K62_RS07740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4K62_RS07750	COG0363	glucosamine-6-phosphate deaminase activity
E4K62_RS07765	COG0166	Belongs to the GPI family
E4K62_RS07770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4K62_RS07780	COG0109	protoheme IX farnesyltransferase activity
E4K62_RS07790	COG1612	heme a metabolic process
E4K62_RS07810	COG0396	ATPase activity
E4K62_RS07815	COG2151	metal-sulfur cluster biosynthetic enzyme
E4K62_RS07820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4K62_RS07825	COG2814	Major facilitator Superfamily
E4K62_RS07835	COG0577	efflux transmembrane transporter activity
E4K62_RS07835	COG1136	(ABC) transporter
E4K62_RS07850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4K62_RS07855	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4K62_RS07860	COG1120	ATPase activity
E4K62_RS07870	COG0488	(ABC) transporter
E4K62_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS07905	COG0560	Phosphoserine phosphatase
E4K62_RS07915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4K62_RS07920	COG0297	glycogen (starch) synthase activity
E4K62_RS07925	COG1119	ATPase activity
E4K62_RS07930	COG0254	rRNA binding
E4K62_RS07965	COG0022	dehydrogenase e1 component
E4K62_RS07970	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K62_RS07975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4K62_RS07985	COG1960	acyl-CoA dehydrogenase activity
E4K62_RS08015	COG0588	phosphoglycerate mutase activity
E4K62_RS08040	COG2755	lipolytic protein G-D-S-L family
E4K62_RS08060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4K62_RS08070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4K62_RS08075	COG1968	undecaprenyl-diphosphatase activity
E4K62_RS08085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4K62_RS08100	COG2378	regulation of single-species biofilm formation
E4K62_RS08110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4K62_RS08115	COG0805	protein transport
E4K62_RS08135	COG0584	glycerophosphoryl diester phosphodiesterase
E4K62_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS08155	COG1506	peptidase
E4K62_RS08155	COG0823	Involved in the tonB-independent uptake of proteins
E4K62_RS08155	COG4946	Tricorn protease homolog
E4K62_RS08175	COG2815	serine threonine protein kinase
E4K62_RS08175	COG0515	serine threonine protein kinase
E4K62_RS08190	COG1609	Transcriptional regulator
E4K62_RS08195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K62_RS08200	COG0477	Major facilitator Superfamily
E4K62_RS08210	COG1309	transcriptional regulator
E4K62_RS08245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4K62_RS08275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4K62_RS08305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4K62_RS08330	COG0789	Transcriptional regulator
E4K62_RS08335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4K62_RS08375	COG1349	DNA-binding transcription factor activity
E4K62_RS08380	COG1063	alcohol dehydrogenase
E4K62_RS08385	COG0584	glycerophosphoryl diester phosphodiesterase
E4K62_RS08395	COG0395	ABC-type sugar transport system, permease component
E4K62_RS08410	COG1063	alcohol dehydrogenase
E4K62_RS08415	COG1105	Belongs to the carbohydrate kinase PfkB family
E4K62_RS08425	COG1285	pathogenesis
E4K62_RS08445	COG0477	Major facilitator Superfamily
E4K62_RS08455	COG1253	flavin adenine dinucleotide binding
E4K62_RS08495	COG0469	pyruvate kinase activity
E4K62_RS08505	COG0069	glutamate synthase activity
E4K62_RS08505	COG0070	glutamate synthase
E4K62_RS08505	COG0067	glutamate synthase
E4K62_RS08510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4K62_RS08515	COG0159	tryptophan synthase activity
E4K62_RS08520	COG0133	tryptophan synthase activity
E4K62_RS08525	COG0134	indole-3-glycerol-phosphate synthase activity
E4K62_RS08540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4K62_RS08545	COG0107	imidazoleglycerol-phosphate synthase activity
E4K62_RS08550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4K62_RS08555	COG0140	phosphoribosyl-ATP diphosphatase activity
E4K62_RS08560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4K62_RS08570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4K62_RS08580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4K62_RS08585	COG1758	RNA polymerase activity
E4K62_RS08590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS08600	COG1116	anion transmembrane transporter activity
E4K62_RS08605	COG0194	GDP metabolic process
E4K62_RS08610	COG0284	orotidine-5'-phosphate decarboxylase activity
E4K62_RS08615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4K62_RS08620	COG0505	Belongs to the CarA family
E4K62_RS08630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K62_RS08635	COG0540	Belongs to the ATCase OTCase family
E4K62_RS08640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4K62_RS08650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4K62_RS08655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4K62_RS08660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4K62_RS08670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4K62_RS08690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4K62_RS08700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4K62_RS08705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4K62_RS08715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4K62_RS08720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4K62_RS08730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4K62_RS08755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4K62_RS08760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4K62_RS08765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4K62_RS08775	COG2255	four-way junction helicase activity
E4K62_RS08780	COG0632	four-way junction helicase activity
E4K62_RS08785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4K62_RS08790	COG0217	transcriptional regulatory protein
E4K62_RS08810	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E4K62_RS08815	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4K62_RS08830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4K62_RS08845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4K62_RS08920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4K62_RS08940	COG0596	Alpha beta hydrolase
E4K62_RS08955	COG0183	Belongs to the thiolase family
E4K62_RS08960	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K62_RS08960	COG1024	Enoyl-CoA hydratase
E4K62_RS08965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4K62_RS08970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4K62_RS08985	COG0756	dUTP diphosphatase activity
E4K62_RS09005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4K62_RS09010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4K62_RS09015	COG0187	DNA topoisomerase II activity
E4K62_RS09025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4K62_RS09030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4K62_RS09045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4K62_RS09055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4K62_RS09060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K62_RS09065	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K62_RS09085	COG0174	glutamine synthetase
E4K62_RS09090	COG1131	(ABC) transporter
E4K62_RS09120	COG1140	nitrate reductase beta subunit
E4K62_RS09125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4K62_RS09155	COG0747	negative chemotaxis
E4K62_RS09160	COG0601	transmembrane transport
E4K62_RS09165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS09170	COG0444	Belongs to the ABC transporter superfamily
E4K62_RS09175	COG4608	Belongs to the ABC transporter superfamily
E4K62_RS09195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4K62_RS09235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4K62_RS09240	COG2140	Oxalate decarboxylase
E4K62_RS09270	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS09295	COG4948	Mandelate Racemase Muconate Lactonizing
E4K62_RS09300	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K62_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS09310	COG3618	amidohydrolase
E4K62_RS09320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4K62_RS09325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K62_RS09330	COG1869	D-ribose catabolic process
E4K62_RS09335	COG2188	Transcriptional regulator
E4K62_RS09340	COG0800	Aldolase
E4K62_RS09355	COG1414	Transcriptional regulator
E4K62_RS09365	COG0246	Mannitol dehydrogenase
E4K62_RS09370	COG0477	Major facilitator Superfamily
E4K62_RS09375	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4K62_RS09380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4K62_RS09395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4K62_RS09400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4K62_RS09420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4K62_RS09440	COG1846	Transcriptional regulator
E4K62_RS09465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4K62_RS09485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4K62_RS09490	COG0358	DNA primase activity
E4K62_RS09495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4K62_RS09505	COG0386	Belongs to the glutathione peroxidase family
E4K62_RS09515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4K62_RS09520	COG1381	Involved in DNA repair and RecF pathway recombination
E4K62_RS09525	COG2860	membrane
E4K62_RS09530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4K62_RS09540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4K62_RS09545	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E4K62_RS09555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4K62_RS09565	COG0537	adenosine 5'-monophosphoramidase activity
E4K62_RS09575	COG0484	heat shock protein binding
E4K62_RS09580	COG1420	regulation of RNA biosynthetic process
E4K62_RS09600	COG1733	regulation of RNA biosynthetic process
E4K62_RS09605	COG0481	GTPase activity
E4K62_RS09615	COG2267	carboxylic ester hydrolase activity
E4K62_RS09620	COG0268	Binds directly to 16S ribosomal RNA
E4K62_RS09635	COG1596	polysaccharide export
E4K62_RS09635	COG1555	photosystem II stabilization
E4K62_RS09645	COG0495	leucyl-tRNA aminoacylation
E4K62_RS09650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4K62_RS09650	COG0512	Glutamine amidotransferase of anthranilate synthase
E4K62_RS09665	COG2135	peptidase activity
E4K62_RS09670	COG2267	carboxylic ester hydrolase activity
E4K62_RS09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K62_RS09700	COG1309	transcriptional regulator
E4K62_RS09715	COG0799	negative regulation of ribosome biogenesis
E4K62_RS09725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4K62_RS09735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4K62_RS09740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E4K62_RS09745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4K62_RS09750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4K62_RS09755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4K62_RS09765	COG1530	ribonuclease E activity
E4K62_RS09780	COG0105	UTP biosynthetic process
E4K62_RS09790	COG0285	dihydrofolate synthase activity
E4K62_RS09795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4K62_RS09800	COG4172	Belongs to the ABC transporter superfamily
E4K62_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K62_RS09810	COG0601	transmembrane transport
E4K62_RS09815	COG4166	transmembrane transport
E4K62_RS09820	COG0525	valine-tRNA ligase activity
E4K62_RS09855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4K62_RS09860	COG0740	serine-type endopeptidase activity
E4K62_RS09865	COG0740	serine-type endopeptidase activity
E4K62_RS09875	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4K62_RS09895	COG2755	lipolytic protein G-D-S-L family
E4K62_RS09895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4K62_RS09900	COG0783	Belongs to the Dps family
E4K62_RS09925	COG0698	ribose 5-phosphate isomerase
E4K62_RS09930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4K62_RS09940	COG0668	transmembrane transport
E4K62_RS09960	COG1946	Acyl-CoA thioesterase
E4K62_RS09980	COG0629	single-stranded DNA binding
E4K62_RS09985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K62_RS09995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K62_RS10015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4K62_RS10055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4K62_RS10060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K62_RS10065	COG0154	amidase activity
E4K62_RS10070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K62_RS10075	COG0318	PFAM AMP-dependent synthetase and ligase
E4K62_RS10080	COG1301	dicarboxylic acid transport
E4K62_RS10085	COG0667	Aldo Keto reductase
E4K62_RS10100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4K62_RS10105	COG0482	sulfurtransferase activity
E4K62_RS10120	COG0366	Alpha amylase catalytic
E4K62_RS10125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4K62_RS10130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K62_RS10135	COG0697	spore germination
E4K62_RS10145	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K62_RS10150	COG3118	belongs to the thioredoxin family
E4K62_RS10190	COG0233	cytoplasmic translational termination
E4K62_RS10195	COG0528	UMP kinase activity
E4K62_RS10200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4K62_RS10205	COG0052	Belongs to the universal ribosomal protein uS2 family
E4K62_RS10235	COG0792	nuclease activity
E4K62_RS10245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4K62_RS10255	COG0335	large ribosomal subunit rRNA binding
E4K62_RS10270	COG0336	Belongs to the RNA methyltransferase TrmD family
E4K62_RS10275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4K62_RS10280	COG1837	Belongs to the UPF0109 family
E4K62_RS10285	COG0228	four-way junction DNA binding
E4K62_RS10290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E4K62_RS10300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4K62_RS10320	COG0552	protein localization to endoplasmic reticulum
E4K62_RS10340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4K62_RS10345	COG0571	ribonuclease III activity
E4K62_RS10350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4K62_RS10360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4K62_RS10370	COG0742	ribosomal rna small subunit methyltransferase
E4K62_RS10385	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4K62_RS10390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4K62_RS10400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4K62_RS10405	COG0066	3-isopropylmalate dehydratase activity
E4K62_RS10410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4K62_RS10420	COG1595	DNA-templated transcription, initiation
E4K62_RS10450	COG0318	PFAM AMP-dependent synthetase and ligase
E4K62_RS10485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4K62_RS10490	COG0583	DNA-binding transcription factor activity
E4K62_RS10500	COG2814	Major facilitator Superfamily
E4K62_RS10505	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K62_RS10510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4K62_RS10515	COG0473	3-isopropylmalate dehydrogenase activity
E4K62_RS10520	COG0477	Major facilitator Superfamily
E4K62_RS10550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4K62_RS10565	COG0129	dihydroxy-acid dehydratase activity
E4K62_RS10575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4K62_RS10585	COG0300	oxidoreductase activity
E4K62_RS10590	COG0753	catalase activity
E4K62_RS10620	COG0483	inositol monophosphate 1-phosphatase activity
E4K62_RS10630	COG0745	RESPONSE REGULATOR receiver
E4K62_RS10635	COG2205	protein histidine kinase activity
E4K62_RS10660	COG0328	RNA-DNA hybrid ribonuclease activity
E4K62_RS10680	COG1051	belongs to the nudix hydrolase family
E4K62_RS10685	COG1733	regulation of RNA biosynthetic process
E4K62_RS10705	COG0640	Transcriptional regulator
E4K62_RS10725	COG1595	DNA-templated transcription, initiation
E4K62_RS10740	COG1595	DNA-templated transcription, initiation
E4K62_RS10745	COG0657	acetylesterase activity
E4K62_RS10840	COG2826	transposase and inactivated derivatives, IS30 family
E4K62_RS10860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4K62_RS10875	COG2197	response regulator
E4K62_RS10880	COG0515	serine threonine protein kinase
E4K62_RS10895	COG3409	Peptidoglycan-binding domain 1 protein
E4K62_RS11010	COG0583	DNA-binding transcription factor activity
E4K62_RS11025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4K62_RS11030	COG2177	Part of the ABC transporter FtsEX involved in
E4K62_RS11035	COG2884	Cell division ATP-binding protein ftsE
E4K62_RS11040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4K62_RS11125	COG0739	heme binding
E4K62_RS11205	COG1222	aaa ATPase
E4K62_RS11215	COG2197	response regulator
E4K62_RS11230	COG3250	beta-galactosidase activity
E4K62_RS11245	COG1175	transmembrane transport
E4K62_RS11250	COG0395	ABC-type sugar transport system, permease component
E4K62_RS11270	COG1793	dna ligase
E4K62_RS11270	COG3285	dna ligase
E4K62_RS11280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4K62_RS11285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4K62_RS11290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4K62_RS11315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4K62_RS11340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4K62_RS11345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4K62_RS11350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K62_RS11360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4K62_RS11375	COG1846	Transcriptional regulator
E4K62_RS11415	COG1615	UPF0182 protein
E4K62_RS11420	COG3480	Lon protease (S16) C-terminal proteolytic domain
E4K62_RS11445	COG0210	DNA helicase
E4K62_RS11470	COG0513	Belongs to the DEAD box helicase family
E4K62_RS11485	COG0006	proline dipeptidase activity
E4K62_RS11500	COG2239	Acts as a magnesium transporter
E4K62_RS11535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4K62_RS11540	COG2171	N-acyltransferase activity
E4K62_RS11545	COG1620	l-lactate permease
E4K62_RS11580	COG1217	gtp-binding protein TYPA
E4K62_RS11585	COG4172	Belongs to the ABC transporter superfamily
E4K62_RS11605	COG0747	negative chemotaxis
E4K62_RS11620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4K62_RS11620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4K62_RS11625	COG0509	glycine decarboxylation via glycine cleavage system
E4K62_RS11630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K62_RS11640	COG1216	Glycosyl transferase, family 2
E4K62_RS11640	COG1442	glycosyl transferase family 8
E4K62_RS11650	COG1309	transcriptional regulator
E4K62_RS11655	COG1132	(ABC) transporter
E4K62_RS11660	COG2814	Major facilitator Superfamily
E4K62_RS11665	COG0693	protein deglycase activity
E4K62_RS11675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4K62_RS11680	COG4585	Histidine kinase
E4K62_RS11685	COG2197	response regulator
E4K62_RS11725	COG0028	Belongs to the TPP enzyme family
E4K62_RS11745	COG0531	amino acid
E4K62_RS11770	COG0583	DNA-binding transcription factor activity
E4K62_RS11775	COG0488	(ABC) transporter
E4K62_RS11820	COG2207	Transcriptional regulator
E4K62_RS11820	COG3708	Transcriptional regulator
E4K62_RS11825	COG1739	Uncharacterized protein family UPF0029
E4K62_RS11850	COG1309	transcriptional regulator
E4K62_RS11895	COG0012	GTP binding
E4K62_RS11905	COG2176	DNA-directed DNA polymerase activity
E4K62_RS11910	COG1322	Protein conserved in bacteria
E4K62_RS11935	COG0191	fructose-bisphosphate aldolase activity
E4K62_RS11940	COG2258	MOSC domain
E4K62_RS11950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4K62_RS11955	COG1570	exodeoxyribonuclease VII activity
E4K62_RS11960	COG1722	exodeoxyribonuclease VII activity
E4K62_RS11975	COG0114	fumarate hydratase activity
E4K62_RS11980	COG2205	protein histidine kinase activity
E4K62_RS11990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4K62_RS12015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4K62_RS12020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4K62_RS12030	COG3214	Protein conserved in bacteria
E4K62_RS12040	COG1704	LemA family
E4K62_RS12055	COG4251	negative regulation of phosphorylation
E4K62_RS12060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4K62_RS12065	COG2871	sodium ion transport
E4K62_RS12100	COG0148	phosphopyruvate hydratase activity
E4K62_RS12105	COG4122	O-methyltransferase activity
E4K62_RS12130	COG0124	histidyl-tRNA synthetase
E4K62_RS12140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4K62_RS12145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4K62_RS12160	COG0193	aminoacyl-tRNA hydrolase activity
E4K62_RS12165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4K62_RS12170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4K62_RS12185	COG0745	RESPONSE REGULATOR receiver
E4K62_RS12190	COG2205	protein histidine kinase activity
E4K62_RS12195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K62_RS12195	COG1017	nitric oxide dioxygenase activity
E4K62_RS12210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4K62_RS12215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4K62_RS12230	COG0488	(ABC) transporter
E4K62_RS12235	COG4249	Peptidase C14 caspase catalytic subunit p20
E4K62_RS12245	COG1174	glycine betaine transport
E4K62_RS12265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4K62_RS12270	COG0667	Aldo Keto reductase
E4K62_RS12285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4K62_RS12290	COG0477	Major facilitator Superfamily
E4K62_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS12310	COG0084	hydrolase, TatD family'
E4K62_RS12315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K62_RS12330	COG1331	Highly conserved protein containing a thioredoxin domain
E4K62_RS12340	COG1643	Atp-dependent helicase
E4K62_RS12345	COG0604	alcohol dehydrogenase
E4K62_RS12345	COG3321	synthase
E4K62_RS12350	COG4214	carbohydrate transport
E4K62_RS12355	COG1129	ABC transporter
E4K62_RS12360	COG4213	ABC transporter substrate-binding protein
E4K62_RS12370	COG1609	Transcriptional regulator
E4K62_RS12380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4K62_RS12395	COG4213	ABC transporter substrate-binding protein
E4K62_RS12405	COG4214	carbohydrate transport
E4K62_RS12420	COG1793	dna ligase
E4K62_RS12430	COG0542	response to heat
E4K62_RS12455	COG2813	Specifically methylates the guanine in position
E4K62_RS12465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4K62_RS12470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4K62_RS12475	COG1780	Probably involved in ribonucleotide reductase function
E4K62_RS12505	COG2733	membrane
E4K62_RS12515	COG1609	Transcriptional regulator
E4K62_RS12530	COG0395	ABC-type sugar transport system, permease component
E4K62_RS12565	COG3527	Alpha-acetolactate decarboxylase
E4K62_RS12575	COG0673	inositol 2-dehydrogenase activity
E4K62_RS12620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4K62_RS12635	COG1970	mechanosensitive ion channel activity
E4K62_RS12650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4K62_RS12655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4K62_RS12665	COG2197	response regulator
E4K62_RS12775	COG2814	Major facilitator Superfamily
E4K62_RS12780	COG2267	carboxylic ester hydrolase activity
E4K62_RS12785	COG0789	Transcriptional regulator
E4K62_RS12865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K62_RS12880	COG2514	catechol 2,3-dioxygenase activity
E4K62_RS12930	COG1278	Cold shock
E4K62_RS12965	COG0587	DNA-directed DNA polymerase activity
E4K62_RS12995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4K62_RS13005	COG1278	Cold shock
E4K62_RS13020	COG1061	Type III restriction enzyme res subunit
E4K62_RS13030	COG3345	alpha-galactosidase
E4K62_RS13035	COG0673	inositol 2-dehydrogenase activity
E4K62_RS13040	COG1063	alcohol dehydrogenase
E4K62_RS13045	COG0395	ABC-type sugar transport system, permease component
E4K62_RS13065	COG0745	RESPONSE REGULATOR receiver
E4K62_RS13070	COG5002	protein histidine kinase activity
E4K62_RS13070	COG5000	phosphorelay sensor kinase activity
E4K62_RS13080	COG0459	protein refolding
E4K62_RS13105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K62_RS13180	COG3842	ATPase activity
E4K62_RS13190	COG2910	NAD(P)H-binding
E4K62_RS13195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K62_RS13200	COG0215	cysteine-tRNA ligase activity
E4K62_RS13205	COG0697	spore germination
E4K62_RS13210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4K62_RS13225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4K62_RS13225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4K62_RS13240	COG0745	RESPONSE REGULATOR receiver
E4K62_RS13245	COG5002	protein histidine kinase activity
E4K62_RS13265	COG0588	phosphoglycerate mutase activity
E4K62_RS13280	COG4044	May play a role in the intracellular transport of hydrophobic ligands
E4K62_RS13290	COG0745	RESPONSE REGULATOR receiver
E4K62_RS13295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4K62_RS13300	COG0494	nUDIX hydrolase
E4K62_RS13300	COG0406	alpha-ribazole phosphatase activity
E4K62_RS13325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4K62_RS13360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4K62_RS13370	COG1464	Belongs to the NlpA lipoprotein family
E4K62_RS13390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS13405	COG1335	isochorismatase
E4K62_RS13410	COG2409	Drug exporters of the RND superfamily
E4K62_RS13435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4K62_RS13440	COG1754	DNA topoisomerase type I activity
E4K62_RS13440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4K62_RS13470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K62_RS13490	COG1408	metallophosphoesterase
E4K62_RS13515	COG2186	Transcriptional regulator
E4K62_RS13525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4K62_RS13530	COG1435	thymidine kinase activity
E4K62_RS13535	COG0579	oxidoreductase
E4K62_RS13550	COG0697	spore germination
E4K62_RS13555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4K62_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS13570	COG1879	ABC-type sugar transport system periplasmic component
E4K62_RS13575	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS13580	COG1129	ABC transporter
E4K62_RS13585	COG1063	alcohol dehydrogenase
E4K62_RS13605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4K62_RS13620	COG0714	Associated with various cellular activities
E4K62_RS13640	COG2217	Heavy metal translocating P-type atpase
E4K62_RS13655	COG1937	Protein conserved in bacteria
E4K62_RS13675	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4K62_RS13680	COG2957	Belongs to the agmatine deiminase family
E4K62_RS13690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K62_RS13695	COG0659	secondary active sulfate transmembrane transporter activity
E4K62_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS13740	COG3546	catalase activity
E4K62_RS13780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS13790	COG1476	TRANSCRIPTIONal
E4K62_RS13835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E4K62_RS13860	COG1105	Belongs to the carbohydrate kinase PfkB family
E4K62_RS13865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4K62_RS13895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4K62_RS13900	COG1271	oxidase subunit
E4K62_RS13905	COG1294	oxidase, subunit
E4K62_RS13910	COG4988	ABC transporter
E4K62_RS13915	COG1132	(ABC) transporter
E4K62_RS13945	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4K62_RS13960	COG0315	cyclic pyranopterin monophosphate synthase activity
E4K62_RS13975	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4K62_RS13975	COG0315	cyclic pyranopterin monophosphate synthase activity
E4K62_RS13980	COG0702	epimerase
E4K62_RS13995	COG2814	Major facilitator Superfamily
E4K62_RS14015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4K62_RS14020	COG0395	ABC-type sugar transport system, permease component
E4K62_RS14025	COG1175	transmembrane transport
E4K62_RS14030	COG1653	transport
E4K62_RS14035	COG1609	Transcriptional regulator
E4K62_RS14040	COG0222	ribosome binding
E4K62_RS14045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4K62_RS14075	COG3321	synthase
E4K62_RS14075	COG0604	alcohol dehydrogenase
E4K62_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS14080	COG3347	Dehydrogenase
E4K62_RS14085	COG1070	Carbohydrate kinase
E4K62_RS14090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4K62_RS14095	COG1830	Aldolase
E4K62_RS14100	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS14110	COG1129	ABC transporter
E4K62_RS14120	COG2188	Transcriptional regulator
E4K62_RS14125	COG0583	DNA-binding transcription factor activity
E4K62_RS14135	COG1254	Belongs to the acylphosphatase family
E4K62_RS14140	COG1126	abc transporter atp-binding protein
E4K62_RS14145	COG0765	amino acid transport
E4K62_RS14150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K62_RS14155	COG0081	regulation of translation
E4K62_RS14160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4K62_RS14170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4K62_RS14215	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS14260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K62_RS14270	COG4166	transmembrane transport
E4K62_RS14280	COG4608	Belongs to the ABC transporter superfamily
E4K62_RS14285	COG0444	Belongs to the ABC transporter superfamily
E4K62_RS14335	COG3201	nicotinamide mononucleotide transporter
E4K62_RS14345	COG0436	Aminotransferase
E4K62_RS14350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4K62_RS14360	COG2030	dehydratase
E4K62_RS14365	COG0730	response to heat
E4K62_RS14380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4K62_RS14400	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E4K62_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS14410	COG0783	Belongs to the Dps family
E4K62_RS14415	COG3387	PFAM Glycoside hydrolase 15-related
E4K62_RS14430	COG0405	Gamma-glutamyltransferase
E4K62_RS14440	COG1121	(ABC) transporter
E4K62_RS14445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4K62_RS14490	COG5343	regulation of RNA biosynthetic process
E4K62_RS14520	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4K62_RS14555	COG0657	acetylesterase activity
E4K62_RS14565	COG0657	acetylesterase activity
E4K62_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS14605	COG3833	ABC-type maltose transport systems, permease component
E4K62_RS14610	COG1175	transmembrane transport
E4K62_RS14620	COG1666	GTP binding
E4K62_RS14650	COG0395	ABC-type sugar transport system, permease component
E4K62_RS14665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K62_RS14675	COG1082	Xylose isomerase domain protein TIM barrel
E4K62_RS14680	COG1940	carbohydrate kinase activity
E4K62_RS14710	COG0142	geranyltranstransferase activity
E4K62_RS14715	COG2226	methyltransferase
E4K62_RS14755	COG2326	polyphosphate kinase activity
E4K62_RS14760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4K62_RS14785	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4K62_RS14805	COG4948	Mandelate Racemase Muconate Lactonizing
E4K62_RS14815	COG2409	Drug exporters of the RND superfamily
E4K62_RS14830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4K62_RS14835	COG1333	cytochrome c biogenesis protein
E4K62_RS14840	COG0785	Cytochrome C biogenesis protein
E4K62_RS14850	COG0406	alpha-ribazole phosphatase activity
E4K62_RS14855	COG0586	Pfam SNARE associated Golgi protein
E4K62_RS14880	COG0017	Asparaginyl-tRNA synthetase
E4K62_RS14895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4K62_RS14935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4K62_RS14940	COG0569	domain protein
E4K62_RS14945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4K62_RS14960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS14965	COG0590	tRNA wobble adenosine to inosine editing
E4K62_RS14970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4K62_RS14980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4K62_RS14980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4K62_RS15000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4K62_RS15010	COG0419	ATPase involved in DNA repair
E4K62_RS15060	COG1501	Belongs to the glycosyl hydrolase 31 family
E4K62_RS15065	COG0395	ABC-type sugar transport system, permease component
E4K62_RS15070	COG1175	transmembrane transport
E4K62_RS15080	COG1609	Transcriptional regulator
E4K62_RS15085	COG0745	RESPONSE REGULATOR receiver
E4K62_RS15105	COG0697	spore germination
E4K62_RS15140	COG0110	maltose O-acetyltransferase activity
E4K62_RS15160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4K62_RS15175	COG1126	abc transporter atp-binding protein
E4K62_RS15180	COG0765	amino acid transport
E4K62_RS15205	COG1846	Transcriptional regulator
E4K62_RS15210	COG0363	glucosamine-6-phosphate deaminase activity
E4K62_RS15220	COG1175	transmembrane transport
E4K62_RS15240	COG1486	melibiose metabolic process
E4K62_RS15260	COG1846	Transcriptional regulator
E4K62_RS15290	COG2017	converts alpha-aldose to the beta-anomer
E4K62_RS15295	COG2160	L-arabinose isomerase activity
E4K62_RS15305	COG1609	Transcriptional regulator
E4K62_RS15315	COG1131	(ABC) transporter
E4K62_RS15350	COG1802	Transcriptional regulator
E4K62_RS15360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4K62_RS15365	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K62_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS15380	COG3265	gluconokinase activity
E4K62_RS15390	COG2814	Major facilitator Superfamily
E4K62_RS15395	COG1414	Transcriptional regulator
E4K62_RS15400	COG0183	Belongs to the thiolase family
E4K62_RS15405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4K62_RS15420	COG0477	Major facilitator Superfamily
E4K62_RS15445	COG1024	Enoyl-CoA hydratase
E4K62_RS15450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K62_RS15455	COG2151	metal-sulfur cluster biosynthetic enzyme
E4K62_RS15460	COG3396	Phenylacetate-CoA oxygenase
E4K62_RS15465	COG3460	Phenylacetate-CoA oxygenase
E4K62_RS15470	COG3396	Phenylacetate-CoA oxygenase
E4K62_RS15485	COG2030	dehydratase
E4K62_RS15485	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS15490	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K62_RS15495	COG1024	Enoyl-CoA hydratase
E4K62_RS15500	COG2050	protein possibly involved in aromatic compounds catabolism
E4K62_RS15505	COG0477	Major facilitator Superfamily
E4K62_RS15515	COG3386	PFAM SMP-30 Gluconolaconase
E4K62_RS15540	COG3237	CsbD-like
E4K62_RS15565	COG0596	Alpha beta hydrolase
E4K62_RS15570	COG0577	efflux transmembrane transporter activity
E4K62_RS15570	COG1136	(ABC) transporter
E4K62_RS15580	COG1309	transcriptional regulator
E4K62_RS15600	COG1136	(ABC) transporter
E4K62_RS15615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4K62_RS15620	COG0318	PFAM AMP-dependent synthetase and ligase
E4K62_RS15625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4K62_RS15630	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS15640	COG1131	(ABC) transporter
E4K62_RS15650	COG0604	alcohol dehydrogenase
E4K62_RS15650	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS15650	COG3321	synthase
E4K62_RS15660	COG0813	purine-nucleoside phosphorylase activity
E4K62_RS15665	COG0277	FAD linked oxidase domain protein
E4K62_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS15685	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K62_RS15690	COG1414	Transcriptional regulator
E4K62_RS15695	COG0737	Belongs to the 5'-nucleotidase family
E4K62_RS15700	COG4948	Mandelate Racemase Muconate Lactonizing
E4K62_RS15710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4K62_RS15725	COG1175	transmembrane transport
E4K62_RS15740	COG1802	Transcriptional regulator
E4K62_RS15750	COG1335	isochorismatase
E4K62_RS15760	COG1309	transcriptional regulator
E4K62_RS15825	COG0657	acetylesterase activity
E4K62_RS15830	COG0596	Alpha beta hydrolase
E4K62_RS15850	COG1063	alcohol dehydrogenase
E4K62_RS15895	COG0657	acetylesterase activity
E4K62_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS15910	COG0514	ATP-dependent DNA helicase (RecQ)
E4K62_RS15920	COG2197	response regulator
E4K62_RS15925	COG4585	Histidine kinase
E4K62_RS15940	COG0768	penicillin binding
E4K62_RS15950	COG0583	DNA-binding transcription factor activity
E4K62_RS16005	COG0492	ferredoxin-NADP+ reductase activity
E4K62_RS16010	COG0798	PFAM Bile acid sodium symporter
E4K62_RS16015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K62_RS16020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K62_RS16025	COG0659	secondary active sulfate transmembrane transporter activity
E4K62_RS16080	COG0739	heme binding
E4K62_RS16105	COG1192	Involved in chromosome partitioning
E4K62_RS16125	COG0629	single-stranded DNA binding
E4K62_RS16140	COG2226	methyltransferase
E4K62_RS16170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4K62_RS16245	COG4974	Belongs to the 'phage' integrase family
E4K62_RS16255	COG1316	TRANSCRIPTIONal
E4K62_RS16270	COG0561	phosphatase activity
E4K62_RS16275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4K62_RS16285	COG0415	Belongs to the DNA photolyase family
E4K62_RS16290	COG2314	TM2 domain
E4K62_RS16295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS16300	COG0477	Major facilitator Superfamily
E4K62_RS16305	COG1902	pentaerythritol trinitrate reductase activity
E4K62_RS16305	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K62_RS16315	COG0384	phenazine biosynthesis protein PhzF
E4K62_RS16330	COG1929	Belongs to the glycerate kinase type-1 family
E4K62_RS16345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4K62_RS16350	COG2267	carboxylic ester hydrolase activity
E4K62_RS16365	COG1063	alcohol dehydrogenase
E4K62_RS16375	COG0006	proline dipeptidase activity
E4K62_RS16380	COG2084	Dehydrogenase
E4K62_RS16395	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS16420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4K62_RS16425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS16430	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4K62_RS16435	COG0095	Lipoate-protein ligase
E4K62_RS16445	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS16450	COG1129	ABC transporter
E4K62_RS16455	COG1879	ABC-type sugar transport system periplasmic component
E4K62_RS16460	COG0673	inositol 2-dehydrogenase activity
E4K62_RS16485	COG0477	Major facilitator Superfamily
E4K62_RS16490	COG1609	Transcriptional regulator
E4K62_RS16505	COG2814	Major facilitator Superfamily
E4K62_RS16510	COG3347	Dehydrogenase
E4K62_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS16515	COG1070	Carbohydrate kinase
E4K62_RS16540	COG1072	(Pantothenic acid kinase))
E4K62_RS16545	COG1063	alcohol dehydrogenase
E4K62_RS16560	COG1070	Carbohydrate kinase
E4K62_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS16570	COG1879	ABC-type sugar transport system periplasmic component
E4K62_RS16575	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4K62_RS16595	COG1609	Transcriptional regulator
E4K62_RS16600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4K62_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS16610	COG0246	Mannitol dehydrogenase
E4K62_RS16625	COG0673	inositol 2-dehydrogenase activity
E4K62_RS16650	COG1175	transmembrane transport
E4K62_RS16655	COG0395	ABC-type sugar transport system, permease component
E4K62_RS16680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4K62_RS16685	COG0251	oxidation-reduction process
E4K62_RS16695	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS16700	COG1305	Transglutaminase-like
E4K62_RS16715	COG2814	Major facilitator Superfamily
E4K62_RS16720	COG0129	dihydroxy-acid dehydratase activity
E4K62_RS16725	COG2081	HI0933 family
E4K62_RS16730	COG1414	Transcriptional regulator
E4K62_RS16735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS16775	COG1063	alcohol dehydrogenase
E4K62_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS16800	COG1960	acyl-CoA dehydrogenase activity
E4K62_RS16805	COG1414	Transcriptional regulator
E4K62_RS16810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4K62_RS16815	COG1834	amidinotransferase
E4K62_RS16820	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS16840	COG0395	ABC-type sugar transport system, permease component
E4K62_RS16845	COG1175	transmembrane transport
E4K62_RS16855	COG1609	Transcriptional regulator
E4K62_RS16880	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E4K62_RS16880	COG0778	Nitroreductase
E4K62_RS16885	COG1846	Transcriptional regulator
E4K62_RS16910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4K62_RS16920	COG0183	Belongs to the thiolase family
E4K62_RS16930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4K62_RS16935	COG2079	MmgE PrpD family protein
E4K62_RS16950	COG1131	(ABC) transporter
E4K62_RS16955	COG3559	Exporter of polyketide antibiotics
E4K62_RS16965	COG0667	Aldo Keto reductase
E4K62_RS16970	COG2197	response regulator
E4K62_RS16985	COG1131	(ABC) transporter
E4K62_RS17005	COG1131	(ABC) transporter
E4K62_RS17010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4K62_RS17030	COG0300	oxidoreductase activity
E4K62_RS17055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K62_RS17070	COG1122	ATPase activity
E4K62_RS17075	COG4721	ABC-type cobalt transport system, permease component
E4K62_RS17085	COG0471	metal ion transport
E4K62_RS17085	COG0490	domain, Protein
E4K62_RS17090	COG0484	heat shock protein binding
E4K62_RS17095	COG1024	Enoyl-CoA hydratase
E4K62_RS17100	COG1131	(ABC) transporter
E4K62_RS17115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E4K62_RS17120	COG2072	flavoprotein involved in K transport
E4K62_RS17125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K62_RS17130	COG1920	GTP binding
E4K62_RS17135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4K62_RS17140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4K62_RS17145	COG0113	porphobilinogen synthase activity
E4K62_RS17155	COG0181	hydroxymethylbilane synthase activity
E4K62_RS17160	COG3253	May function as heme-dependent peroxidase
E4K62_RS17185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4K62_RS17205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4K62_RS17220	COG0423	glycine-tRNA ligase activity
E4K62_RS17230	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS17245	COG0579	oxidoreductase
E4K62_RS17260	COG2814	Major facilitator Superfamily
E4K62_RS17275	COG3104	oligopeptide transport
E4K62_RS17280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4K62_RS17285	COG0596	Alpha beta hydrolase
E4K62_RS17290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4K62_RS17300	COG3485	protocatechuate 3,4-dioxygenase
E4K62_RS17305	COG2807	transmembrane transport
E4K62_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS17320	COG1960	acyl-CoA dehydrogenase activity
E4K62_RS17345	COG1116	anion transmembrane transporter activity
E4K62_RS17350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS17355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS17370	COG3962	Belongs to the TPP enzyme family
E4K62_RS17380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K62_RS17380	COG1116	anion transmembrane transporter activity
E4K62_RS17385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS17390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K62_RS17405	COG1414	Transcriptional regulator
E4K62_RS17410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4K62_RS17420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K62_RS17430	COG0302	gtp cyclohydrolase
E4K62_RS17435	COG2376	Dihydroxyacetone kinase
E4K62_RS17440	COG1461	Dihydroxyacetone kinase
E4K62_RS17450	COG0191	fructose-bisphosphate aldolase activity
E4K62_RS17480	COG3284	Transcriptional regulator
E4K62_RS17525	COG2130	NADP-dependent
E4K62_RS17535	COG4221	oxidoreductase activity
E4K62_RS17540	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS17555	COG4177	L-phenylalanine transmembrane transporter activity
E4K62_RS17570	COG0411	ABC transporter
E4K62_RS17580	COG0318	PFAM AMP-dependent synthetase and ligase
E4K62_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS17600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K62_RS17605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4K62_RS17620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4K62_RS17635	COG3842	ATPase activity
E4K62_RS17680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K62_RS17695	COG0765	amino acid transport
E4K62_RS17710	COG3590	peptidase
E4K62_RS17720	COG2217	Heavy metal translocating P-type atpase
E4K62_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
E4K62_RS17760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4K62_RS17785	COG2197	response regulator
E4K62_RS17795	COG4152	abc transporter atp-binding protein
E4K62_RS17805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4K62_RS17820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K62_RS17825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K62_RS17835	COG0542	response to heat
E4K62_RS17875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4K62_RS17890	COG1609	Transcriptional regulator
E4K62_RS17915	COG0395	ABC-type sugar transport system, permease component
E4K62_RS17935	COG1397	ADP-ribosylglycohydrolase
E4K62_RS17950	COG1175	transmembrane transport
E4K62_RS17955	COG0395	ABC-type sugar transport system, permease component
E4K62_RS17960	COG0789	Transcriptional regulator
E4K62_RS17965	COG0484	heat shock protein binding
E4K62_RS17970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4K62_RS17975	COG0443	Heat shock 70 kDa protein
E4K62_RS17980	COG2270	Major facilitator Superfamily
E4K62_RS18000	COG0717	Belongs to the dCTP deaminase family
E4K62_RS18005	COG1959	2 iron, 2 sulfur cluster binding
E4K62_RS18030	COG4095	Psort location CytoplasmicMembrane, score
E4K62_RS18040	COG2079	MmgE PrpD family protein
E4K62_RS18045	COG1024	Enoyl-CoA hydratase
E4K62_RS18045	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K62_RS18080	COG2084	Dehydrogenase
E4K62_RS18085	COG1012	belongs to the aldehyde dehydrogenase family
E4K62_RS18090	COG1802	Transcriptional regulator
E4K62_RS18120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K62_RS18130	COG0318	PFAM AMP-dependent synthetase and ligase
E4K62_RS18160	COG5398	heme oxygenase
E4K62_RS18165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4K62_RS18185	COG0776	regulation of translation
E4K62_RS18195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4K62_RS18200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4K62_RS18205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4K62_RS18210	COG2094	Belongs to the DNA glycosylase MPG family
E4K62_RS18225	COG0701	Predicted permease
E4K62_RS18255	COG1121	(ABC) transporter
E4K62_RS18260	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4K62_RS18265	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K62_RS18270	COG0022	dehydrogenase e1 component
E4K62_RS18280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4K62_RS18285	COG1950	PFAM Membrane protein of
E4K62_RS18300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K62_RS18310	COG2188	Transcriptional regulator
E4K62_RS18325	COG0395	ABC-type sugar transport system, permease component
E4K62_RS18330	COG1175	transmembrane transport
E4K62_RS18355	COG2267	carboxylic ester hydrolase activity
E4K62_RS18360	COG0395	ABC-type sugar transport system, permease component
E4K62_RS18365	COG1175	transmembrane transport
E4K62_RS18385	COG1653	transport
E4K62_RS18390	COG1175	transmembrane transport
E4K62_RS18395	COG0395	ABC-type sugar transport system, permease component
E4K62_RS18400	COG1063	alcohol dehydrogenase
E4K62_RS18420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K62_RS18425	COG1414	Transcriptional regulator
E4K62_RS18430	COG0789	Transcriptional regulator
E4K62_RS18450	COG0305	Participates in initiation and elongation during chromosome replication
E4K62_RS18465	COG0359	binds to the 23S rRNA
E4K62_RS18470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4K62_RS18480	COG0360	Binds together with S18 to 16S ribosomal RNA
E4K62_RS18500	COG0617	tRNA 3'-terminal CCA addition
E4K62_RS18505	COG2890	protein-(glutamine-N5) methyltransferase activity
E4K62_RS18520	COG0492	ferredoxin-NADP+ reductase activity
E4K62_RS18525	COG3118	belongs to the thioredoxin family
E4K62_RS18545	COG1192	Involved in chromosome partitioning
E4K62_RS18550	COG0357	Ribosomal RNA small subunit methyltransferase G
E4K62_RS18560	COG0706	membrane insertase activity
E4K62_RS18565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4K62_RS18570	COG0594	ribonuclease P activity
E4K62_RS18575	COG0230	Belongs to the bacterial ribosomal protein bL34 family