locus-tag	class	description
C6C15_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6C15_RS00010	COG0592	DNA-directed DNA polymerase activity
C6C15_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6C15_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C6C15_RS00025	COG0187	DNA topoisomerase II activity
C6C15_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6C15_RS00040	COG4585	Histidine kinase
C6C15_RS00045	COG2197	response regulator
C6C15_RS00080	COG0442	prolyl-tRNA aminoacylation
C6C15_RS00095	COG0705	Rhomboid family
C6C15_RS00105	COG3764	Sortase (surface protein transpeptidase)
C6C15_RS00115	COG2815	serine threonine protein kinase
C6C15_RS00115	COG0515	serine threonine protein kinase
C6C15_RS00120	COG0515	serine threonine protein kinase
C6C15_RS00125	COG0768	penicillin binding
C6C15_RS00140	COG1716	ATPase activity
C6C15_RS00145	COG1716	ATPase activity
C6C15_RS00170	COG0387	Pfam Sodium calcium exchanger
C6C15_RS00225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6C15_RS00230	COG1278	Cold shock
C6C15_RS00235	COG0546	phosphoglycolate phosphatase activity
C6C15_RS00245	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C6C15_RS00260	COG2197	response regulator
C6C15_RS00265	COG0738	Major facilitator superfamily
C6C15_RS00280	COG2111	Na H antiporter
C6C15_RS00280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6C15_RS00290	COG0651	ATP synthesis coupled electron transport
C6C15_RS00300	COG2212	antiporter activity
C6C15_RS00305	COG1320	monovalent cation:proton antiporter activity
C6C15_RS00400	COG0714	Associated with various cellular activities
C6C15_RS00405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6C15_RS00415	COG0697	spore germination
C6C15_RS00435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6C15_RS00450	COG1268	BioY protein
C6C15_RS00455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6C15_RS00465	COG1125	glycine betaine transport
C6C15_RS00465	COG0517	IMP dehydrogenase activity
C6C15_RS00470	COG1174	glycine betaine transport
C6C15_RS00475	COG1174	glycine betaine transport
C6C15_RS00490	COG1605	Chorismate mutase
C6C15_RS00490	COG0287	Prephenate dehydrogenase
C6C15_RS00495	COG0318	PFAM AMP-dependent synthetase and ligase
C6C15_RS00515	COG1846	Transcriptional regulator
C6C15_RS00515	COG1940	carbohydrate kinase activity
C6C15_RS00535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6C15_RS00545	COG1105	Belongs to the carbohydrate kinase PfkB family
C6C15_RS00605	COG1131	(ABC) transporter
C6C15_RS00615	COG2813	Specifically methylates the guanine in position
C6C15_RS00625	COG4176	ABC-type proline glycine betaine transport system permease component
C6C15_RS00635	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C6C15_RS00665	COG2197	response regulator
C6C15_RS00675	COG1136	(ABC) transporter
C6C15_RS00675	COG0577	efflux transmembrane transporter activity
C6C15_RS00690	COG2197	response regulator
C6C15_RS00725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C6C15_RS00730	COG3340	Belongs to the peptidase S51 family
C6C15_RS00755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C6C15_RS00790	COG1404	Belongs to the peptidase S8 family
C6C15_RS00795	COG0598	Magnesium transport protein CorA
C6C15_RS00800	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS00810	COG0673	inositol 2-dehydrogenase activity
C6C15_RS00815	COG1940	carbohydrate kinase activity
C6C15_RS00825	COG1175	transmembrane transport
C6C15_RS00830	COG0395	ABC-type sugar transport system, permease component
C6C15_RS00845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6C15_RS00860	COG0531	amino acid
C6C15_RS00870	COG0492	ferredoxin-NADP+ reductase activity
C6C15_RS00885	COG1802	Transcriptional regulator
C6C15_RS00895	COG0747	negative chemotaxis
C6C15_RS00900	COG0601	transmembrane transport
C6C15_RS00905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS00935	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS00940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6C15_RS00955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6C15_RS00990	COG2409	Drug exporters of the RND superfamily
C6C15_RS01000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6C15_RS01020	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C6C15_RS01040	COG2378	regulation of single-species biofilm formation
C6C15_RS01085	COG3795	YCII-related domain
C6C15_RS01135	COG0659	secondary active sulfate transmembrane transporter activity
C6C15_RS01155	COG1609	Transcriptional regulator
C6C15_RS01160	COG1178	ABC-type Fe3 transport system permease component
C6C15_RS01165	COG3842	ATPase activity
C6C15_RS01170	COG1840	ABC-type Fe3 transport system, periplasmic component
C6C15_RS01180	COG1216	Glycosyl transferase, family 2
C6C15_RS01190	COG2188	Transcriptional regulator
C6C15_RS01200	COG1175	transmembrane transport
C6C15_RS01205	COG0395	ABC-type sugar transport system, permease component
C6C15_RS01215	COG1940	carbohydrate kinase activity
C6C15_RS01230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6C15_RS01235	COG0702	epimerase
C6C15_RS01240	COG0738	Major facilitator superfamily
C6C15_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS01305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS01315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6C15_RS01320	COG0581	inorganic phosphate transmembrane transporter activity
C6C15_RS01325	COG0573	inorganic phosphate transmembrane transporter activity
C6C15_RS01330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6C15_RS01350	COG0492	ferredoxin-NADP+ reductase activity
C6C15_RS01360	COG0492	ferredoxin-NADP+ reductase activity
C6C15_RS01365	COG3118	belongs to the thioredoxin family
C6C15_RS01370	COG0798	PFAM Bile acid sodium symporter
C6C15_RS01375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS01380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS01450	COG2217	Heavy metal translocating P-type atpase
C6C15_RS01465	COG1937	Protein conserved in bacteria
C6C15_RS01495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6C15_RS01530	COG0328	RNA-DNA hybrid ribonuclease activity
C6C15_RS01560	COG2205	protein histidine kinase activity
C6C15_RS01565	COG0745	RESPONSE REGULATOR receiver
C6C15_RS01575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6C15_RS01580	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6C15_RS01590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6C15_RS01610	COG0813	purine-nucleoside phosphorylase activity
C6C15_RS01640	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C6C15_RS01640	COG1672	PFAM Archaeal ATPase
C6C15_RS01645	COG1278	Cold shock
C6C15_RS01655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6C15_RS01660	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6C15_RS01665	COG1120	ATPase activity
C6C15_RS01675	COG1120	ATPase activity
C6C15_RS01680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6C15_RS01690	COG2267	carboxylic ester hydrolase activity
C6C15_RS01715	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C6C15_RS01725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C6C15_RS01750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6C15_RS01755	COG0531	amino acid
C6C15_RS01765	COG2357	RelA SpoT domain protein
C6C15_RS01785	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS01795	COG0601	transmembrane transport
C6C15_RS01800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS01805	COG1472	Belongs to the glycosyl hydrolase 3 family
C6C15_RS01840	COG1609	Transcriptional regulator
C6C15_RS01845	COG0366	Alpha amylase catalytic
C6C15_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS01860	COG0047	phosphoribosylformylglycinamidine synthase activity
C6C15_RS01870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6C15_RS01880	COG1175	transmembrane transport
C6C15_RS01885	COG0395	ABC-type sugar transport system, permease component
C6C15_RS01890	COG2723	6-phospho-beta-galactosidase activity
C6C15_RS01915	COG1914	H( )-stimulated, divalent metal cation uptake system
C6C15_RS01920	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6C15_RS01925	COG4336	lyase activity
C6C15_RS01930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6C15_RS01935	COG4770	biotin carboxylase activity
C6C15_RS01940	COG2233	PERMEase
C6C15_RS01945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6C15_RS01960	COG0765	amino acid transport
C6C15_RS01965	COG1126	abc transporter atp-binding protein
C6C15_RS01970	COG0151	Belongs to the GarS family
C6C15_RS01985	COG1120	ATPase activity
C6C15_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6C15_RS01995	COG4558	Periplasmic binding protein
C6C15_RS02035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6C15_RS02050	COG1609	Transcriptional regulator
C6C15_RS02060	COG0366	Alpha amylase catalytic
C6C15_RS02060	COG1470	cell adhesion involved in biofilm formation
C6C15_RS02110	COG0778	Nitroreductase
C6C15_RS02125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6C15_RS02135	COG1175	transmembrane transport
C6C15_RS02150	COG0673	inositol 2-dehydrogenase activity
C6C15_RS02160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6C15_RS02165	COG2017	converts alpha-aldose to the beta-anomer
C6C15_RS02170	COG0513	Belongs to the DEAD box helicase family
C6C15_RS02190	COG1960	acyl-CoA dehydrogenase activity
C6C15_RS02200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C6C15_RS02205	COG1122	ATPase activity
C6C15_RS02220	COG1966	Carbon starvation protein
C6C15_RS02230	COG3275	phosphorelay sensor kinase activity
C6C15_RS02245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6C15_RS02260	COG0514	ATP-dependent DNA helicase (RecQ)
C6C15_RS02275	COG0519	Catalyzes the synthesis of GMP from XMP
C6C15_RS02280	COG2815	serine threonine protein kinase
C6C15_RS02280	COG0515	serine threonine protein kinase
C6C15_RS02290	COG0714	Associated with various cellular activities
C6C15_RS02340	COG1404	Belongs to the peptidase S8 family
C6C15_RS02385	COG1404	Belongs to the peptidase S8 family
C6C15_RS02430	COG1674	ftsk spoiiie
C6C15_RS02475	COG0039	L-malate dehydrogenase activity
C6C15_RS02525	COG0463	Glycosyl transferase, family 2
C6C15_RS02535	COG1088	dTDP-glucose 4,6-dehydratase activity
C6C15_RS02550	COG0438	transferase activity, transferring glycosyl groups
C6C15_RS02580	COG3291	Pkd domain containing protein
C6C15_RS02590	COG3206	protein involved in exopolysaccharide biosynthesis
C6C15_RS02590	COG0489	protein tyrosine kinase activity
C6C15_RS02615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6C15_RS02625	COG1309	transcriptional regulator
C6C15_RS02640	COG3239	Fatty acid desaturase
C6C15_RS02680	COG0596	Alpha beta hydrolase
C6C15_RS02715	COG1401	restriction endodeoxyribonuclease activity
C6C15_RS02740	COG0785	Cytochrome C biogenesis protein
C6C15_RS02770	COG3336	cytochrome c oxidase
C6C15_RS02795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6C15_RS02810	COG2072	flavoprotein involved in K transport
C6C15_RS02850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS02855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS02860	COG0798	PFAM Bile acid sodium symporter
C6C15_RS02865	COG3118	belongs to the thioredoxin family
C6C15_RS02870	COG0492	ferredoxin-NADP+ reductase activity
C6C15_RS02880	COG1937	Protein conserved in bacteria
C6C15_RS02885	COG2217	Heavy metal translocating P-type atpase
C6C15_RS02950	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C6C15_RS03085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6C15_RS03090	COG0037	tRNA processing
C6C15_RS03100	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6C15_RS03105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6C15_RS03110	COG0302	gtp cyclohydrolase
C6C15_RS03115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6C15_RS03120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6C15_RS03155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6C15_RS03175	COG1597	lipid kinase activity
C6C15_RS03180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6C15_RS03185	COG0561	phosphatase activity
C6C15_RS03195	COG1316	TRANSCRIPTIONal
C6C15_RS03200	COG1070	Carbohydrate kinase
C6C15_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS03205	COG3347	Dehydrogenase
C6C15_RS03240	COG1129	ABC transporter
C6C15_RS03245	COG1609	Transcriptional regulator
C6C15_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS03270	COG0733	neurotransmitter:sodium symporter activity
C6C15_RS03280	COG2207	Transcriptional regulator
C6C15_RS03280	COG3708	Transcriptional regulator
C6C15_RS03300	COG0822	iron-sulfur transferase activity
C6C15_RS03335	COG0583	DNA-binding transcription factor activity
C6C15_RS03340	COG1053	succinate dehydrogenase
C6C15_RS03350	COG1760	l-serine dehydratase
C6C15_RS03360	COG1309	transcriptional regulator
C6C15_RS03365	COG1131	(ABC) transporter
C6C15_RS03375	COG1643	Atp-dependent helicase
C6C15_RS03390	COG1064	alcohol dehydrogenase
C6C15_RS03405	COG2130	NADP-dependent
C6C15_RS03415	COG0017	Asparaginyl-tRNA synthetase
C6C15_RS03425	COG1253	flavin adenine dinucleotide binding
C6C15_RS03430	COG0010	Belongs to the arginase family
C6C15_RS03445	COG2197	response regulator
C6C15_RS03450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6C15_RS03500	COG1690	Belongs to the RtcB family
C6C15_RS03515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6C15_RS03565	COG0419	ATPase involved in DNA repair
C6C15_RS03590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6C15_RS03620	COG0569	domain protein
C6C15_RS03625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6C15_RS03630	COG0640	Transcriptional regulator
C6C15_RS03650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6C15_RS03670	COG0765	amino acid transport
C6C15_RS03675	COG1126	abc transporter atp-binding protein
C6C15_RS03680	COG3842	ATPase activity
C6C15_RS03710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6C15_RS03720	COG0406	alpha-ribazole phosphatase activity
C6C15_RS03740	COG0785	Cytochrome C biogenesis protein
C6C15_RS03750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6C15_RS03765	COG2409	Drug exporters of the RND superfamily
C6C15_RS03770	COG1309	transcriptional regulator
C6C15_RS03775	COG4948	Mandelate Racemase Muconate Lactonizing
C6C15_RS03790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6C15_RS03805	COG4585	Histidine kinase
C6C15_RS03810	COG2197	response regulator
C6C15_RS03815	COG1136	(ABC) transporter
C6C15_RS03815	COG0577	efflux transmembrane transporter activity
C6C15_RS03850	COG1316	TRANSCRIPTIONal
C6C15_RS03865	COG0395	ABC-type sugar transport system, permease component
C6C15_RS03870	COG1472	Belongs to the glycosyl hydrolase 3 family
C6C15_RS03875	COG1737	Transcriptional regulator
C6C15_RS03885	COG0747	negative chemotaxis
C6C15_RS03890	COG0601	transmembrane transport
C6C15_RS03895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS03905	COG0085	RNA polymerase activity
C6C15_RS03910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6C15_RS03945	COG0483	inositol monophosphate 1-phosphatase activity
C6C15_RS03950	COG0739	heme binding
C6C15_RS04010	COG3237	CsbD-like
C6C15_RS04015	COG1595	DNA-templated transcription, initiation
C6C15_RS04030	COG0702	epimerase
C6C15_RS04035	COG1733	regulation of RNA biosynthetic process
C6C15_RS04045	COG0101	tRNA pseudouridine synthase activity
C6C15_RS04055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6C15_RS04060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6C15_RS04065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6C15_RS04070	COG0248	Ppx GppA phosphatase
C6C15_RS04075	COG1072	(Pantothenic acid kinase))
C6C15_RS04080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6C15_RS04085	COG0736	holo-[acyl-carrier-protein] synthase activity
C6C15_RS04090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6C15_RS04095	COG0802	atpase or kinase
C6C15_RS04100	COG0745	RESPONSE REGULATOR receiver
C6C15_RS04105	COG5002	protein histidine kinase activity
C6C15_RS04120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6C15_RS04125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C6C15_RS04130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6C15_RS04135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6C15_RS04150	COG1338	Plays a role in the flagellum-specific transport system
C6C15_RS04180	COG0739	heme binding
C6C15_RS04190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C6C15_RS04205	COG1157	protein secretion by the type III secretion system
C6C15_RS04215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6C15_RS04220	COG1766	The M ring may be actively involved in energy transduction
C6C15_RS04225	COG1677	Flagellar hook-basal body complex protein FliE
C6C15_RS04235	COG1815	bacterial-type flagellum-dependent cell motility
C6C15_RS04245	COG1516	flagellar protein fliS
C6C15_RS04255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6C15_RS04275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6C15_RS04280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C6C15_RS04285	COG1214	PFAM Peptidase M22, glycoprotease
C6C15_RS04285	COG0456	acetyltransferase
C6C15_RS04295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6C15_RS04320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6C15_RS04370	COG0745	RESPONSE REGULATOR receiver
C6C15_RS04380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6C15_RS04385	COG1215	transferase activity, transferring glycosyl groups
C6C15_RS04395	COG2205	protein histidine kinase activity
C6C15_RS04400	COG0488	(ABC) transporter
C6C15_RS04405	COG0516	GMP reductase activity
C6C15_RS04415	COG0737	Belongs to the 5'-nucleotidase family
C6C15_RS04415	COG1525	nuclease
C6C15_RS04415	COG4085	toxin activity
C6C15_RS04425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6C15_RS04425	COG0519	Catalyzes the synthesis of GMP from XMP
C6C15_RS04430	COG0297	glycogen (starch) synthase activity
C6C15_RS04440	COG4941	Belongs to the sigma-70 factor family
C6C15_RS04445	COG2261	transglycosylase associated protein
C6C15_RS04460	COG3304	Inner membrane component domain
C6C15_RS04495	COG1793	dna ligase
C6C15_RS04510	COG0456	acetyltransferase
C6C15_RS04510	COG0454	-acetyltransferase
C6C15_RS04520	COG1309	transcriptional regulator
C6C15_RS04530	COG0045	succinate-CoA ligase (ADP-forming) activity
C6C15_RS04540	COG2252	PERMEase
C6C15_RS04555	COG0138	bifunctional purine biosynthesis protein purh
C6C15_RS04565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6C15_RS04565	COG2169	Transcriptional regulator
C6C15_RS04575	COG1132	(ABC) transporter
C6C15_RS04590	COG2838	Isocitrate dehydrogenase
C6C15_RS04620	COG1940	carbohydrate kinase activity
C6C15_RS04625	COG0363	glucosamine-6-phosphate deaminase activity
C6C15_RS04630	COG1051	belongs to the nudix hydrolase family
C6C15_RS04635	COG0277	FAD linked oxidase domain protein
C6C15_RS04650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C6C15_RS04660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6C15_RS04665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6C15_RS04685	COG3971	2-oxopent-4-enoate hydratase activity
C6C15_RS04695	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS04700	COG1802	Transcriptional regulator
C6C15_RS04710	COG0477	Major facilitator Superfamily
C6C15_RS04715	COG1414	Transcriptional regulator
C6C15_RS04725	COG1131	(ABC) transporter
C6C15_RS04735	COG4585	Histidine kinase
C6C15_RS04740	COG2197	response regulator
C6C15_RS04750	COG0384	phenazine biosynthesis protein PhzF
C6C15_RS04760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C6C15_RS04765	COG1793	dna ligase
C6C15_RS04775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6C15_RS04780	COG2151	metal-sulfur cluster biosynthetic enzyme
C6C15_RS04785	COG3396	Phenylacetate-CoA oxygenase
C6C15_RS04790	COG3460	Phenylacetate-CoA oxygenase
C6C15_RS04795	COG3396	Phenylacetate-CoA oxygenase
C6C15_RS04805	COG0514	ATP-dependent DNA helicase (RecQ)
C6C15_RS04815	COG2376	Dihydroxyacetone kinase
C6C15_RS04820	COG1461	Dihydroxyacetone kinase
C6C15_RS04825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6C15_RS04835	COG2050	protein possibly involved in aromatic compounds catabolism
C6C15_RS04845	COG1309	transcriptional regulator
C6C15_RS04850	COG2030	dehydratase
C6C15_RS04850	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS04855	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6C15_RS04860	COG1024	Enoyl-CoA hydratase
C6C15_RS04870	COG0477	Major facilitator Superfamily
C6C15_RS04875	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6C15_RS04880	COG0022	dehydrogenase e1 component
C6C15_RS04900	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS04915	COG2149	membrane
C6C15_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS04945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6C15_RS04990	COG1737	Transcriptional regulator
C6C15_RS05000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C6C15_RS05015	COG3226	Transcriptional regulator
C6C15_RS05025	COG2814	Major facilitator Superfamily
C6C15_RS05040	COG0667	Aldo Keto reductase
C6C15_RS05045	COG1063	alcohol dehydrogenase
C6C15_RS05060	COG0747	negative chemotaxis
C6C15_RS05065	COG0601	transmembrane transport
C6C15_RS05070	COG0444	Belongs to the ABC transporter superfamily
C6C15_RS05075	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS05080	COG1309	transcriptional regulator
C6C15_RS05115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6C15_RS05120	COG1132	(ABC) transporter
C6C15_RS05145	COG0477	Major facilitator Superfamily
C6C15_RS05165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6C15_RS05170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6C15_RS05170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6C15_RS05185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6C15_RS05205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6C15_RS05210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C6C15_RS05215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6C15_RS05225	COG0124	histidyl-tRNA synthetase
C6C15_RS05230	COG2755	lipolytic protein G-D-S-L family
C6C15_RS05270	COG4122	O-methyltransferase activity
C6C15_RS05275	COG0148	phosphopyruvate hydratase activity
C6C15_RS05325	COG1704	LemA family
C6C15_RS05335	COG3214	Protein conserved in bacteria
C6C15_RS05345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6C15_RS05350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6C15_RS05370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6C15_RS05380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6C15_RS05385	COG0114	fumarate hydratase activity
C6C15_RS05390	COG0288	reversible hydration of carbon dioxide
C6C15_RS05400	COG1722	exodeoxyribonuclease VII activity
C6C15_RS05405	COG1570	exodeoxyribonuclease VII activity
C6C15_RS05410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6C15_RS05425	COG0191	fructose-bisphosphate aldolase activity
C6C15_RS05440	COG1322	Protein conserved in bacteria
C6C15_RS05445	COG2176	DNA-directed DNA polymerase activity
C6C15_RS05445	COG5002	protein histidine kinase activity
C6C15_RS05455	COG0012	GTP binding
C6C15_RS05490	COG3546	catalase activity
C6C15_RS05520	COG0783	Belongs to the Dps family
C6C15_RS05545	COG2814	Major facilitator Superfamily
C6C15_RS05550	COG1132	(ABC) transporter
C6C15_RS05560	COG1215	transferase activity, transferring glycosyl groups
C6C15_RS05565	COG1104	cysteine desulfurase activity
C6C15_RS05575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C6C15_RS05580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6C15_RS05595	COG0601	transmembrane transport
C6C15_RS05605	COG0444	Belongs to the ABC transporter superfamily
C6C15_RS05615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6C15_RS05620	COG0509	glycine decarboxylation via glycine cleavage system
C6C15_RS05625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6C15_RS05625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6C15_RS05630	COG4166	transmembrane transport
C6C15_RS05640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS05645	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS05660	COG1217	gtp-binding protein TYPA
C6C15_RS05670	COG2066	Belongs to the glutaminase family
C6C15_RS05715	COG0513	Belongs to the DEAD box helicase family
C6C15_RS05720	COG2171	N-acyltransferase activity
C6C15_RS05725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6C15_RS05745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6C15_RS05765	COG2239	Acts as a magnesium transporter
C6C15_RS05780	COG0006	proline dipeptidase activity
C6C15_RS05795	COG3739	integral membrane protein
C6C15_RS05800	COG0513	Belongs to the DEAD box helicase family
C6C15_RS05825	COG0210	DNA helicase
C6C15_RS05855	COG3480	Lon protease (S16) C-terminal proteolytic domain
C6C15_RS05860	COG1615	UPF0182 protein
C6C15_RS05880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6C15_RS05890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6C15_RS05895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6C15_RS05900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6C15_RS05990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6C15_RS06005	COG0438	transferase activity, transferring glycosyl groups
C6C15_RS06020	COG1132	(ABC) transporter
C6C15_RS06035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6C15_RS06035	COG2755	lipolytic protein G-D-S-L family
C6C15_RS06040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C6C15_RS06065	COG1216	Glycosyl transferase, family 2
C6C15_RS06070	COG1216	Glycosyl transferase, family 2
C6C15_RS06090	COG1482	cell wall glycoprotein biosynthetic process
C6C15_RS06135	COG0714	Associated with various cellular activities
C6C15_RS06155	COG0745	RESPONSE REGULATOR receiver
C6C15_RS06160	COG5000	phosphorelay sensor kinase activity
C6C15_RS06160	COG5002	protein histidine kinase activity
C6C15_RS06165	COG5401	PFAM Sporulation and spore germination
C6C15_RS06190	COG0653	protein targeting
C6C15_RS06250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6C15_RS06255	COG1595	DNA-templated transcription, initiation
C6C15_RS06265	COG4552	Acetyltransferase involved in intracellular survival and related
C6C15_RS06270	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6C15_RS06270	COG0567	Dehydrogenase, E1 component
C6C15_RS06280	COG1253	flavin adenine dinucleotide binding
C6C15_RS06290	COG1902	pentaerythritol trinitrate reductase activity
C6C15_RS06295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6C15_RS06295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6C15_RS06310	COG2814	Major facilitator Superfamily
C6C15_RS06320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6C15_RS06335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C6C15_RS06350	COG0444	Belongs to the ABC transporter superfamily
C6C15_RS06355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS06360	COG0601	transmembrane transport
C6C15_RS06365	COG0747	negative chemotaxis
C6C15_RS06370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6C15_RS06370	COG0596	Alpha beta hydrolase
C6C15_RS06375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6C15_RS06400	COG1842	Phage shock protein A
C6C15_RS06415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6C15_RS06455	COG2909	trisaccharide binding
C6C15_RS06475	COG0628	permease
C6C15_RS06515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6C15_RS06540	COG2217	Heavy metal translocating P-type atpase
C6C15_RS06550	COG1063	alcohol dehydrogenase
C6C15_RS06555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6C15_RS06570	COG0018	arginyl-trna synthetase
C6C15_RS06580	COG0596	Alpha beta hydrolase
C6C15_RS06585	COG1309	transcriptional regulator
C6C15_RS06590	COG0596	Alpha beta hydrolase
C6C15_RS06605	COG0460	homoserine dehydrogenase
C6C15_RS06610	COG0083	homoserine kinase activity
C6C15_RS06620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6C15_RS06625	COG4565	transcriptional regulatory protein
C6C15_RS06630	COG3290	protein histidine kinase activity
C6C15_RS06635	COG2851	Citrate transporter
C6C15_RS06640	COG1045	serine acetyltransferase
C6C15_RS06650	COG2890	protein-(glutamine-N5) methyltransferase activity
C6C15_RS06660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6C15_RS06670	COG0356	it plays a direct role in the translocation of protons across the membrane
C6C15_RS06675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6C15_RS06680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6C15_RS06685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6C15_RS06690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6C15_RS06695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6C15_RS06700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6C15_RS06705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6C15_RS06710	COG3022	response to hydroperoxide
C6C15_RS06720	COG0631	protein serine/threonine phosphatase activity
C6C15_RS06750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6C15_RS06755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6C15_RS06770	COG0750	zinc metalloprotease
C6C15_RS06780	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C6C15_RS06785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6C15_RS06800	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C6C15_RS06810	COG0442	prolyl-tRNA aminoacylation
C6C15_RS06820	COG1611	Belongs to the LOG family
C6C15_RS06835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6C15_RS06840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6C15_RS06845	COG2197	response regulator
C6C15_RS06850	COG1194	a g-specific adenine glycosylase
C6C15_RS06855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6C15_RS06870	COG0196	riboflavin kinase activity
C6C15_RS06875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6C15_RS06915	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6C15_RS06925	COG0545	Peptidyl-prolyl cis-trans isomerase
C6C15_RS06940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6C15_RS06955	COG2822	iron ion transport
C6C15_RS06960	COG2837	iron assimilation
C6C15_RS06970	COG3594	Acyltransferase
C6C15_RS06995	COG0438	transferase activity, transferring glycosyl groups
C6C15_RS06995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6C15_RS07000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C6C15_RS07005	COG1185	polyribonucleotide nucleotidyltransferase activity
C6C15_RS07010	COG0667	Aldo Keto reductase
C6C15_RS07030	COG1764	response to oxidative stress
C6C15_RS07045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C6C15_RS07065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6C15_RS07070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C6C15_RS07075	COG1674	ftsk spoiiie
C6C15_RS07085	COG1058	Belongs to the CinA family
C6C15_RS07085	COG1546	Belongs to the CinA family
C6C15_RS07090	COG1396	sequence-specific DNA binding
C6C15_RS07100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6C15_RS07105	COG2137	regulation of response to DNA damage stimulus
C6C15_RS07110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6C15_RS07115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6C15_RS07125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6C15_RS07135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6C15_RS07165	COG2932	Transcriptional regulator
C6C15_RS07180	COG1475	DNA binding
C6C15_RS07440	COG0483	inositol monophosphate 1-phosphatase activity
C6C15_RS07470	COG0442	prolyl-tRNA aminoacylation
C6C15_RS07475	COG2814	Major facilitator Superfamily
C6C15_RS07515	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6C15_RS07525	COG0129	dihydroxy-acid dehydratase activity
C6C15_RS07540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6C15_RS07550	COG1940	carbohydrate kinase activity
C6C15_RS07555	COG2182	Extracellular solute-binding protein
C6C15_RS07560	COG1175	transmembrane transport
C6C15_RS07565	COG0395	ABC-type sugar transport system, permease component
C6C15_RS07570	COG1940	carbohydrate kinase activity
C6C15_RS07585	COG1309	transcriptional regulator
C6C15_RS07590	COG0300	oxidoreductase activity
C6C15_RS07595	COG0277	FAD linked oxidase domain protein
C6C15_RS07625	COG1309	transcriptional regulator
C6C15_RS07630	COG0477	Major facilitator Superfamily
C6C15_RS07635	COG0473	3-isopropylmalate dehydrogenase activity
C6C15_RS07640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6C15_RS07650	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6C15_RS07655	COG2814	Major facilitator Superfamily
C6C15_RS07665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6C15_RS07685	COG2814	Major facilitator Superfamily
C6C15_RS07705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6C15_RS07760	COG2873	o-acetylhomoserine
C6C15_RS07765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6C15_RS07770	COG0066	3-isopropylmalate dehydratase activity
C6C15_RS07775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6C15_RS07785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6C15_RS07790	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6C15_RS07805	COG0742	ribosomal rna small subunit methyltransferase
C6C15_RS07815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6C15_RS07825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6C15_RS07830	COG0571	ribonuclease III activity
C6C15_RS07835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6C15_RS07845	COG1136	(ABC) transporter
C6C15_RS07845	COG0577	efflux transmembrane transporter activity
C6C15_RS07880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6C15_RS07885	COG0321	lipoyl(octanoyl) transferase activity
C6C15_RS07890	COG1309	transcriptional regulator
C6C15_RS07900	COG0697	spore germination
C6C15_RS07905	COG0583	DNA-binding transcription factor activity
C6C15_RS07910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6C15_RS07915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6C15_RS07920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6C15_RS07930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6C15_RS07935	COG0228	four-way junction DNA binding
C6C15_RS07940	COG1837	Belongs to the UPF0109 family
C6C15_RS07945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6C15_RS07950	COG0336	Belongs to the RNA methyltransferase TrmD family
C6C15_RS07975	COG0335	large ribosomal subunit rRNA binding
C6C15_RS07980	COG0681	Belongs to the peptidase S26 family
C6C15_RS07985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6C15_RS07995	COG0792	nuclease activity
C6C15_RS08010	COG4974	Belongs to the 'phage' integrase family
C6C15_RS08020	COG0052	Belongs to the universal ribosomal protein uS2 family
C6C15_RS08025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6C15_RS08030	COG0528	UMP kinase activity
C6C15_RS08035	COG0233	cytoplasmic translational termination
C6C15_RS08075	COG3118	belongs to the thioredoxin family
C6C15_RS08080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6C15_RS08085	COG0366	Alpha amylase catalytic
C6C15_RS08100	COG0482	sulfurtransferase activity
C6C15_RS08105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6C15_RS08110	COG0456	acetyltransferase
C6C15_RS08120	COG0318	PFAM AMP-dependent synthetase and ligase
C6C15_RS08125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6C15_RS08130	COG0154	amidase activity
C6C15_RS08135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6C15_RS08140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6C15_RS08160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6C15_RS08170	COG1280	lysine exporter protein (LysE YggA)
C6C15_RS08180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C6C15_RS08195	COG0629	single-stranded DNA binding
C6C15_RS08215	COG1946	Acyl-CoA thioesterase
C6C15_RS08235	COG0668	transmembrane transport
C6C15_RS08245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6C15_RS08270	COG0783	Belongs to the Dps family
C6C15_RS08300	COG1388	LysM domain
C6C15_RS08300	COG4932	domain protein
C6C15_RS08345	COG0022	dehydrogenase e1 component
C6C15_RS08350	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6C15_RS08360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6C15_RS08370	COG1960	acyl-CoA dehydrogenase activity
C6C15_RS08385	COG0406	alpha-ribazole phosphatase activity
C6C15_RS08400	COG2755	lipolytic protein G-D-S-L family
C6C15_RS08425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6C15_RS08430	COG1968	undecaprenyl-diphosphatase activity
C6C15_RS08465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6C15_RS08470	COG0805	protein transport
C6C15_RS08475	COG4581	dead DEAH box helicase
C6C15_RS08490	COG0584	glycerophosphoryl diester phosphodiesterase
C6C15_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS08525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6C15_RS08530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6C15_RS08585	COG0477	Major facilitator Superfamily
C6C15_RS08590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6C15_RS08645	COG0070	glutamate synthase
C6C15_RS08645	COG0069	glutamate synthase activity
C6C15_RS08645	COG0067	glutamate synthase
C6C15_RS08650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6C15_RS08655	COG0159	tryptophan synthase activity
C6C15_RS08660	COG0133	tryptophan synthase activity
C6C15_RS08665	COG0134	indole-3-glycerol-phosphate synthase activity
C6C15_RS08680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6C15_RS08685	COG0107	imidazoleglycerol-phosphate synthase activity
C6C15_RS08690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6C15_RS08695	COG0140	phosphoribosyl-ATP diphosphatase activity
C6C15_RS08700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6C15_RS08710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6C15_RS08715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6C15_RS08720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6C15_RS08725	COG1758	RNA polymerase activity
C6C15_RS08730	COG0194	GDP metabolic process
C6C15_RS08735	COG0284	orotidine-5'-phosphate decarboxylase activity
C6C15_RS08740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6C15_RS08745	COG0505	Belongs to the CarA family
C6C15_RS08755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6C15_RS08760	COG0540	Belongs to the ATCase OTCase family
C6C15_RS08765	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C6C15_RS08775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6C15_RS08775	COG2146	nitrite reductase [NAD(P)H] activity
C6C15_RS08780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6C15_RS08785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6C15_RS08790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6C15_RS08800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6C15_RS08810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6C15_RS08815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6C15_RS08820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6C15_RS08825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6C15_RS08835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6C15_RS08840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6C15_RS08850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6C15_RS08870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6C15_RS08885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6C15_RS08890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6C15_RS08895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6C15_RS08905	COG2255	four-way junction helicase activity
C6C15_RS08910	COG0632	four-way junction helicase activity
C6C15_RS08915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6C15_RS08920	COG0217	transcriptional regulatory protein
C6C15_RS08925	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C6C15_RS08930	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C6C15_RS08940	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C6C15_RS08950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6C15_RS08955	COG1742	UPF0060 membrane protein
C6C15_RS08965	COG0415	Belongs to the DNA photolyase family
C6C15_RS08980	COG2847	Copper chaperone PCu(A)C
C6C15_RS08985	COG2837	iron assimilation
C6C15_RS08990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6C15_RS09035	COG0366	Alpha amylase catalytic
C6C15_RS09040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6C15_RS09065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6C15_RS09095	COG0183	Belongs to the thiolase family
C6C15_RS09100	COG1024	Enoyl-CoA hydratase
C6C15_RS09100	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6C15_RS09115	COG0277	FAD linked oxidase domain protein
C6C15_RS09130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6C15_RS09135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6C15_RS09150	COG0756	dUTP diphosphatase activity
C6C15_RS09175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6C15_RS09180	COG0187	DNA topoisomerase II activity
C6C15_RS09190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6C15_RS09195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6C15_RS09210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6C15_RS09220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6C15_RS09225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6C15_RS09230	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6C15_RS09245	COG0569	domain protein
C6C15_RS09245	COG0189	ligase activity
C6C15_RS09250	COG0189	ligase activity
C6C15_RS09250	COG4067	protein conserved in archaea
C6C15_RS09260	COG0174	glutamine synthetase
C6C15_RS09285	COG0346	lactoylglutathione lyase activity
C6C15_RS09290	COG0515	serine threonine protein kinase
C6C15_RS09300	COG1597	lipid kinase activity
C6C15_RS09305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6C15_RS09310	COG0174	glutamine synthetase
C6C15_RS09340	COG3012	SEC-C Motif Domain Protein
C6C15_RS09355	COG4221	oxidoreductase activity
C6C15_RS09360	COG0039	L-malate dehydrogenase activity
C6C15_RS09365	COG1090	epimerase
C6C15_RS09375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6C15_RS09390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6C15_RS09395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6C15_RS09400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6C15_RS09405	COG2364	Membrane
C6C15_RS09410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6C15_RS09440	COG0254	rRNA binding
C6C15_RS09445	COG1119	ATPase activity
C6C15_RS09450	COG0297	glycogen (starch) synthase activity
C6C15_RS09455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C6C15_RS09460	COG0560	Phosphoserine phosphatase
C6C15_RS09460	COG3830	Belongs to the UPF0237 family
C6C15_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS09500	COG0259	pyridoxamine-phosphate oxidase activity
C6C15_RS09505	COG0488	(ABC) transporter
C6C15_RS09510	COG0586	Pfam SNARE associated Golgi protein
C6C15_RS09515	COG4585	Histidine kinase
C6C15_RS09520	COG2197	response regulator
C6C15_RS09530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C6C15_RS09535	COG1122	ATPase activity
C6C15_RS09550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6C15_RS09555	COG2151	metal-sulfur cluster biosynthetic enzyme
C6C15_RS09560	COG0396	ATPase activity
C6C15_RS09580	COG1612	heme a metabolic process
C6C15_RS09590	COG0109	protoheme IX farnesyltransferase activity
C6C15_RS09600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6C15_RS09605	COG0166	Belongs to the GPI family
C6C15_RS09620	COG0363	glucosamine-6-phosphate deaminase activity
C6C15_RS09645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C6C15_RS09665	COG0358	DNA primase activity
C6C15_RS09680	COG0386	Belongs to the glutathione peroxidase family
C6C15_RS09700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6C15_RS09705	COG1381	Involved in DNA repair and RecF pathway recombination
C6C15_RS09725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6C15_RS09735	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS09735	COG0604	alcohol dehydrogenase
C6C15_RS09735	COG3321	synthase
C6C15_RS09755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6C15_RS09765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6C15_RS09775	COG0537	adenosine 5'-monophosphoramidase activity
C6C15_RS09785	COG0484	heat shock protein binding
C6C15_RS09790	COG1420	regulation of RNA biosynthetic process
C6C15_RS09805	COG2827	Endonuclease containing a URI domain
C6C15_RS09810	COG0481	GTPase activity
C6C15_RS09850	COG2723	6-phospho-beta-galactosidase activity
C6C15_RS09855	COG0268	Binds directly to 16S ribosomal RNA
C6C15_RS09875	COG1555	photosystem II stabilization
C6C15_RS09875	COG1596	polysaccharide export
C6C15_RS09880	COG0495	leucyl-tRNA aminoacylation
C6C15_RS09885	COG0512	Glutamine amidotransferase of anthranilate synthase
C6C15_RS09885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6C15_RS09905	COG1472	Belongs to the glycosyl hydrolase 3 family
C6C15_RS09950	COG4221	oxidoreductase activity
C6C15_RS09955	COG0799	negative regulation of ribosome biogenesis
C6C15_RS09965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6C15_RS09975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6C15_RS09980	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6C15_RS09985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6C15_RS09990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6C15_RS09995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6C15_RS10005	COG1530	ribonuclease E activity
C6C15_RS10015	COG0105	UTP biosynthetic process
C6C15_RS10025	COG0285	dihydrofolate synthase activity
C6C15_RS10030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6C15_RS10050	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS10055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS10065	COG0747	negative chemotaxis
C6C15_RS10075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6C15_RS10075	COG0519	Catalyzes the synthesis of GMP from XMP
C6C15_RS10090	COG4948	Mandelate Racemase Muconate Lactonizing
C6C15_RS10105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6C15_RS10110	COG0747	negative chemotaxis
C6C15_RS10115	COG0601	transmembrane transport
C6C15_RS10120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS10125	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS10130	COG1619	proteins homologs of microcin C7 resistance protein MccF
C6C15_RS10150	COG0525	valine-tRNA ligase activity
C6C15_RS10170	COG0156	8-amino-7-oxononanoate synthase activity
C6C15_RS10175	COG1063	alcohol dehydrogenase
C6C15_RS10180	COG0583	DNA-binding transcription factor activity
C6C15_RS10200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6C15_RS10210	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS10220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C6C15_RS10230	COG0740	serine-type endopeptidase activity
C6C15_RS10235	COG0740	serine-type endopeptidase activity
C6C15_RS10245	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6C15_RS10270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6C15_RS10275	COG0149	triose-phosphate isomerase activity
C6C15_RS10280	COG0126	phosphoglycerate kinase activity
C6C15_RS10285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6C15_RS10290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6C15_RS10295	COG1481	regulation of sporulation
C6C15_RS10300	COG1660	Displays ATPase and GTPase activities
C6C15_RS10305	COG0322	excinuclease ABC activity
C6C15_RS10315	COG1846	Transcriptional regulator
C6C15_RS10330	COG0556	nucleotide-excision repair
C6C15_RS10335	COG0237	dephospho-CoA kinase activity
C6C15_RS10355	COG1832	CoA-binding protein
C6C15_RS10360	COG2873	o-acetylhomoserine
C6C15_RS10365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6C15_RS10370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6C15_RS10375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6C15_RS10380	COG1116	anion transmembrane transporter activity
C6C15_RS10385	COG0539	negative regulation of cytoplasmic translation
C6C15_RS10400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6C15_RS10405	COG1796	DNA polymerase
C6C15_RS10405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6C15_RS10410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6C15_RS10415	COG1845	cytochrome c oxidase, subunit III
C6C15_RS10420	COG2010	Cytochrome c
C6C15_RS10425	COG0723	plastoquinol--plastocyanin reductase activity
C6C15_RS10430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6C15_RS10455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6C15_RS10460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6C15_RS10480	COG0167	dihydroorotate dehydrogenase activity
C6C15_RS10485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6C15_RS10490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6C15_RS10500	COG0587	DNA-directed DNA polymerase activity
C6C15_RS10515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6C15_RS10520	COG3599	regulation of cell shape
C6C15_RS10530	COG1799	cell septum assembly
C6C15_RS10535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C6C15_RS10540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6C15_RS10550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6C15_RS10555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6C15_RS10565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6C15_RS10570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6C15_RS10580	COG0768	penicillin binding
C6C15_RS10590	COG0275	rRNA processing
C6C15_RS10595	COG2001	Belongs to the MraZ family
C6C15_RS10605	COG0142	geranyltranstransferase activity
C6C15_RS10615	COG1388	LysM domain
C6C15_RS10615	COG3942	CHAP domain
C6C15_RS10620	COG2815	serine threonine protein kinase
C6C15_RS10620	COG0515	serine threonine protein kinase
C6C15_RS10625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6C15_RS10630	COG0204	Acyl-transferase
C6C15_RS10635	COG1022	Amp-dependent synthetase and ligase
C6C15_RS10650	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6C15_RS10655	COG1192	Involved in chromosome partitioning
C6C15_RS10670	COG1716	ATPase activity
C6C15_RS10675	COG2372	response to copper ion
C6C15_RS10695	COG3424	synthase
C6C15_RS10725	COG0587	DNA-directed DNA polymerase activity
C6C15_RS10750	COG3973	AAA domain
C6C15_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS10795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C6C15_RS10805	COG0154	amidase activity
C6C15_RS10810	COG2957	Belongs to the agmatine deiminase family
C6C15_RS10925	COG0693	protein deglycase activity
C6C15_RS10940	COG3548	integral membrane protein
C6C15_RS10945	COG0656	L-ascorbic acid biosynthetic process
C6C15_RS10985	COG2801	Transposase and inactivated derivatives
C6C15_RS11045	COG0543	2 iron, 2 sulfur cluster binding
C6C15_RS11065	COG0745	RESPONSE REGULATOR receiver
C6C15_RS11130	COG1160	GTP binding
C6C15_RS11135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6C15_RS11150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6C15_RS11170	COG0494	nUDIX hydrolase
C6C15_RS11175	COG0504	CTP synthase activity
C6C15_RS11180	COG0497	DNA recombination
C6C15_RS11185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6C15_RS11200	COG0647	UMP catabolic process
C6C15_RS11230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6C15_RS11240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6C15_RS11260	COG0165	Argininosuccinate lyase
C6C15_RS11265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6C15_RS11270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6C15_RS11275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6C15_RS11280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6C15_RS11285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6C15_RS11290	COG0352	thiamine-phosphate diphosphorylase activity
C6C15_RS11290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C6C15_RS11290	COG0351	phosphomethylpyrimidine kinase
C6C15_RS11295	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C6C15_RS11305	COG0072	phenylalanine-tRNA ligase activity
C6C15_RS11305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6C15_RS11310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6C15_RS11315	COG0765	amino acid transport
C6C15_RS11320	COG0765	amino acid transport
C6C15_RS11325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6C15_RS11330	COG1126	abc transporter atp-binding protein
C6C15_RS11335	COG2358	TRAP transporter, solute receptor (TAXI family
C6C15_RS11340	COG5002	protein histidine kinase activity
C6C15_RS11350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6C15_RS11355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6C15_RS11360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6C15_RS11365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6C15_RS11380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6C15_RS11385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6C15_RS11390	COG0131	Imidazoleglycerol-phosphate dehydratase
C6C15_RS11395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6C15_RS11405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6C15_RS11410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C6C15_RS11415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C6C15_RS11425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6C15_RS11430	COG2177	Part of the ABC transporter FtsEX involved in
C6C15_RS11435	COG2884	Cell division ATP-binding protein ftsE
C6C15_RS11445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6C15_RS11515	COG0463	Glycosyl transferase, family 2
C6C15_RS11535	COG0586	Pfam SNARE associated Golgi protein
C6C15_RS11540	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C6C15_RS11555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6C15_RS11560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6C15_RS11565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6C15_RS11590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6C15_RS11600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6C15_RS11620	COG2197	response regulator
C6C15_RS11625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6C15_RS11630	COG0424	maF-like protein
C6C15_RS11635	COG4770	biotin carboxylase activity
C6C15_RS11650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6C15_RS11675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6C15_RS11680	COG2213	PTS system mannitol-specific
C6C15_RS11685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6C15_RS11690	COG0246	Mannitol dehydrogenase
C6C15_RS11700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6C15_RS11705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6C15_RS11720	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6C15_RS11725	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6C15_RS11730	COG3845	ABC transporter
C6C15_RS11735	COG1744	ABC transporter substrate-binding protein PnrA-like
C6C15_RS11740	COG0662	Cupin 2, conserved barrel domain protein
C6C15_RS11740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C6C15_RS11745	COG2009	succinate dehydrogenase
C6C15_RS11780	COG0180	Tryptophanyl-tRNA synthetase
C6C15_RS11790	COG0193	aminoacyl-tRNA hydrolase activity
C6C15_RS11795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6C15_RS11800	COG3265	gluconokinase activity
C6C15_RS11810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6C15_RS11820	COG0577	efflux transmembrane transporter activity
C6C15_RS11820	COG1136	(ABC) transporter
C6C15_RS11830	COG0745	RESPONSE REGULATOR receiver
C6C15_RS11835	COG2205	protein histidine kinase activity
C6C15_RS11840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6C15_RS11840	COG1017	nitric oxide dioxygenase activity
C6C15_RS11845	COG1477	protein flavinylation
C6C15_RS11855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6C15_RS11860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6C15_RS11870	COG0454	-acetyltransferase
C6C15_RS11880	COG1959	2 iron, 2 sulfur cluster binding
C6C15_RS11890	COG0564	pseudouridine synthase activity
C6C15_RS11900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6C15_RS11945	COG4214	carbohydrate transport
C6C15_RS11960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6C15_RS11965	COG0667	Aldo Keto reductase
C6C15_RS11970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6C15_RS11980	COG0084	hydrolase, TatD family'
C6C15_RS11985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6C15_RS11990	COG2723	6-phospho-beta-galactosidase activity
C6C15_RS11995	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS12000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS12005	COG0601	transmembrane transport
C6C15_RS12040	COG1113	amino acid transport
C6C15_RS12045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6C15_RS12050	COG1331	Highly conserved protein containing a thioredoxin domain
C6C15_RS12070	COG1643	Atp-dependent helicase
C6C15_RS12095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6C15_RS12100	COG4172	Belongs to the ABC transporter superfamily
C6C15_RS12105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS12110	COG0601	transmembrane transport
C6C15_RS12115	COG0747	negative chemotaxis
C6C15_RS12120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6C15_RS12155	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6C15_RS12160	COG1129	ABC transporter
C6C15_RS12165	COG0673	inositol 2-dehydrogenase activity
C6C15_RS12195	COG1090	epimerase
C6C15_RS12210	COG4989	oxidoreductase activity
C6C15_RS12260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6C15_RS12290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6C15_RS12295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6C15_RS12320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C6C15_RS12325	COG0142	geranyltranstransferase activity
C6C15_RS12350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6C15_RS12355	COG2409	Drug exporters of the RND superfamily
C6C15_RS12380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6C15_RS12390	COG1278	Cold shock
C6C15_RS12405	COG1061	Type III restriction enzyme res subunit
C6C15_RS12415	COG0745	RESPONSE REGULATOR receiver
C6C15_RS12420	COG2205	protein histidine kinase activity
C6C15_RS12430	COG0459	protein refolding
C6C15_RS12450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6C15_RS12465	COG1131	(ABC) transporter
C6C15_RS12475	COG4585	Histidine kinase
C6C15_RS12480	COG2197	response regulator
C6C15_RS12500	COG3842	ATPase activity
C6C15_RS12510	COG2910	NAD(P)H-binding
C6C15_RS12515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6C15_RS12520	COG0215	cysteine-tRNA ligase activity
C6C15_RS12525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6C15_RS12525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C6C15_RS12545	COG5002	protein histidine kinase activity
C6C15_RS12555	COG0588	phosphoglycerate mutase activity
C6C15_RS12575	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C6C15_RS12585	COG0745	RESPONSE REGULATOR receiver
C6C15_RS12590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6C15_RS12615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6C15_RS12660	COG0693	protein deglycase activity
C6C15_RS12680	COG1335	isochorismatase
C6C15_RS12695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6C15_RS12700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6C15_RS12705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6C15_RS12705	COG1754	DNA topoisomerase type I activity
C6C15_RS12735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6C15_RS12750	COG4499	WXG100 protein secretion system (Wss), protein YukC
C6C15_RS12750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6C15_RS12785	COG1435	thymidine kinase activity
C6C15_RS12790	COG0579	oxidoreductase
C6C15_RS12810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6C15_RS12830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6C15_RS12860	COG0714	Associated with various cellular activities
C6C15_RS12875	COG1054	Belongs to the UPF0176 family
C6C15_RS12890	COG1131	(ABC) transporter
C6C15_RS12900	COG2226	methyltransferase
C6C15_RS12945	COG0395	ABC-type sugar transport system, permease component
C6C15_RS12950	COG1175	transmembrane transport
C6C15_RS12955	COG1653	transport
C6C15_RS12960	COG1609	Transcriptional regulator
C6C15_RS12965	COG0222	ribosome binding
C6C15_RS12970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6C15_RS13025	COG1126	abc transporter atp-binding protein
C6C15_RS13030	COG0765	amino acid transport
C6C15_RS13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6C15_RS13040	COG0081	regulation of translation
C6C15_RS13045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6C15_RS13075	COG0028	Belongs to the TPP enzyme family
C6C15_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS13135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6C15_RS13145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6C15_RS13165	COG1396	sequence-specific DNA binding
C6C15_RS13175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6C15_RS13185	COG1522	sequence-specific DNA binding
C6C15_RS13190	COG0686	Belongs to the AlaDH PNT family
C6C15_RS13195	COG0436	Aminotransferase
C6C15_RS13205	COG2610	gluconate transmembrane transporter activity
C6C15_RS13210	COG2084	Dehydrogenase
C6C15_RS13220	COG2188	Transcriptional regulator
C6C15_RS13225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6C15_RS13235	COG2030	dehydratase
C6C15_RS13240	COG2188	Transcriptional regulator
C6C15_RS13245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6C15_RS13250	COG0395	ABC-type sugar transport system, permease component
C6C15_RS13255	COG1175	transmembrane transport
C6C15_RS13260	COG1653	transport
C6C15_RS13265	COG2222	sugar isomerase
C6C15_RS13270	COG0730	response to heat
C6C15_RS13285	COG3181	Tripartite tricarboxylate transporter family receptor
C6C15_RS13290	COG3290	protein histidine kinase activity
C6C15_RS13295	COG0203	ribosomal protein L17
C6C15_RS13300	COG0202	RNA polymerase activity
C6C15_RS13305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6C15_RS13310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6C15_RS13320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6C15_RS13330	COG0024	Methionine aminopeptidase
C6C15_RS13335	COG0563	adenylate kinase activity
C6C15_RS13345	COG0200	Binds to the 23S rRNA
C6C15_RS13350	COG1841	ribosomal large subunit assembly
C6C15_RS13355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6C15_RS13360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6C15_RS13365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6C15_RS13370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6C15_RS13375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6C15_RS13380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6C15_RS13385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6C15_RS13390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6C15_RS13395	COG0255	Belongs to the universal ribosomal protein uL29 family
C6C15_RS13400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6C15_RS13405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6C15_RS13410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6C15_RS13415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6C15_RS13420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6C15_RS13425	COG0089	rRNA binding
C6C15_RS13430	COG0088	Forms part of the polypeptide exit tunnel
C6C15_RS13435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6C15_RS13440	COG0051	transcription antitermination factor activity, RNA binding
C6C15_RS13450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6C15_RS13455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6C15_RS13460	COG0049	tRNA binding
C6C15_RS13465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6C15_RS13505	COG3833	ABC-type maltose transport systems, permease component
C6C15_RS13510	COG1175	transmembrane transport
C6C15_RS13515	COG2182	Extracellular solute-binding protein
C6C15_RS13525	COG1666	GTP binding
C6C15_RS13550	COG0142	geranyltranstransferase activity
C6C15_RS13555	COG2226	methyltransferase
C6C15_RS13565	COG1169	isochorismate synthase
C6C15_RS13570	COG2326	polyphosphate kinase activity
C6C15_RS13575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C6C15_RS13595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6C15_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS13625	COG2089	acid synthase
C6C15_RS13630	COG1083	cytidylyl-transferase
C6C15_RS13675	COG1522	sequence-specific DNA binding
C6C15_RS13700	COG0228	four-way junction DNA binding
C6C15_RS13720	COG0488	(ABC) transporter
C6C15_RS13725	COG1201	RNA secondary structure unwinding
C6C15_RS13730	COG2161	toxin-antitoxin pair type II binding
C6C15_RS13735	COG4115	mRNA cleavage
C6C15_RS13745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6C15_RS13755	COG2197	response regulator
C6C15_RS13790	COG0475	glutathione-regulated potassium exporter activity
C6C15_RS13820	COG0706	membrane insertase activity
C6C15_RS13825	COG5006	permease, DMT superfamily
C6C15_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS13850	COG1058	Belongs to the CinA family
C6C15_RS13850	COG1546	Belongs to the CinA family
C6C15_RS13870	COG3639	organic phosphonate transmembrane transporter activity
C6C15_RS13875	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6C15_RS13880	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C6C15_RS13905	COG1362	aminopeptidase activity
C6C15_RS13920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6C15_RS13935	COG3483	tryptophan 2,3-dioxygenase activity
C6C15_RS13980	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6C15_RS14005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C6C15_RS14060	COG3591	Belongs to the peptidase S1B family
C6C15_RS14060	COG1864	DNA RNA non-specific endonuclease
C6C15_RS14065	COG1902	pentaerythritol trinitrate reductase activity
C6C15_RS14080	COG0477	Major facilitator Superfamily
C6C15_RS14090	COG3336	cytochrome c oxidase
C6C15_RS14125	COG0515	serine threonine protein kinase
C6C15_RS14125	COG2815	serine threonine protein kinase
C6C15_RS14160	COG1120	ATPase activity
C6C15_RS14165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6C15_RS14195	COG1295	ribonuclease BN
C6C15_RS14235	COG4716	Myosin-crossreactive antigen
C6C15_RS14260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6C15_RS14265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6C15_RS14270	COG1780	Probably involved in ribonucleotide reductase function
C6C15_RS14300	COG1522	sequence-specific DNA binding
C6C15_RS14315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6C15_RS14320	COG1937	Protein conserved in bacteria
C6C15_RS14325	COG2733	membrane
C6C15_RS14335	COG1228	amidohydrolase
C6C15_RS14340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6C15_RS14345	COG2986	histidine ammonia-lyase
C6C15_RS14370	COG0477	Major facilitator Superfamily
C6C15_RS14380	COG1802	Transcriptional regulator
C6C15_RS14390	COG1196	nuclear chromosome segregation
C6C15_RS14415	COG4974	Belongs to the 'phage' integrase family
C6C15_RS14455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6C15_RS14500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6C15_RS14585	COG4988	ABC transporter
C6C15_RS14590	COG4988	ABC transporter
C6C15_RS14595	COG1294	oxidase, subunit
C6C15_RS14600	COG1271	oxidase subunit
C6C15_RS14610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C6C15_RS14625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C6C15_RS14650	COG3655	Transcriptional regulator
C6C15_RS14660	COG1301	dicarboxylic acid transport
C6C15_RS14670	COG0789	Transcriptional regulator
C6C15_RS14685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6C15_RS14710	COG1116	anion transmembrane transporter activity
C6C15_RS14720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6C15_RS14725	COG1929	Belongs to the glycerate kinase type-1 family
C6C15_RS14730	COG1609	Transcriptional regulator
C6C15_RS14750	COG0673	inositol 2-dehydrogenase activity
C6C15_RS14755	COG1609	Transcriptional regulator
C6C15_RS14765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6C15_RS14775	COG1609	Transcriptional regulator
C6C15_RS14785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C6C15_RS14795	COG2211	Major facilitator Superfamily
C6C15_RS14815	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS14820	COG1522	sequence-specific DNA binding
C6C15_RS14825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6C15_RS14835	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C6C15_RS14840	COG0095	Lipoate-protein ligase
C6C15_RS14875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6C15_RS14880	COG1834	amidinotransferase
C6C15_RS14885	COG0604	alcohol dehydrogenase
C6C15_RS14890	COG1476	TRANSCRIPTIONal
C6C15_RS14900	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS14915	COG0183	Belongs to the thiolase family
C6C15_RS14930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6C15_RS14985	COG0477	Major facilitator Superfamily
C6C15_RS14995	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C6C15_RS15000	COG2079	MmgE PrpD family protein
C6C15_RS15025	COG1175	transmembrane transport
C6C15_RS15030	COG0395	ABC-type sugar transport system, permease component
C6C15_RS15040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6C15_RS15080	COG0395	ABC-type sugar transport system, permease component
C6C15_RS15095	COG0445	tRNA wobble uridine modification
C6C15_RS15105	COG1349	DNA-binding transcription factor activity
C6C15_RS15150	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6C15_RS15165	COG1609	Transcriptional regulator
C6C15_RS15180	COG4948	Mandelate Racemase Muconate Lactonizing
C6C15_RS15185	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6C15_RS15190	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS15200	COG2186	Transcriptional regulator
C6C15_RS15205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6C15_RS15210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6C15_RS15215	COG1869	D-ribose catabolic process
C6C15_RS15220	COG2188	Transcriptional regulator
C6C15_RS15225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6C15_RS15235	COG2188	Transcriptional regulator
C6C15_RS15245	COG1653	transport
C6C15_RS15250	COG1175	transmembrane transport
C6C15_RS15255	COG0395	ABC-type sugar transport system, permease component
C6C15_RS15260	COG0667	Aldo Keto reductase
C6C15_RS15270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6C15_RS15285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6C15_RS15290	COG0800	Aldolase
C6C15_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS15325	COG0531	amino acid
C6C15_RS15330	COG0076	glutamate decarboxylase activity
C6C15_RS15340	COG1122	ATPase activity
C6C15_RS15345	COG4721	ABC-type cobalt transport system, permease component
C6C15_RS15350	COG1686	Belongs to the peptidase S11 family
C6C15_RS15390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6C15_RS15405	COG0181	hydroxymethylbilane synthase activity
C6C15_RS15410	COG3253	May function as heme-dependent peroxidase
C6C15_RS15435	COG0640	Transcriptional regulator
C6C15_RS15440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6C15_RS15445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6C15_RS15450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6C15_RS15470	COG0488	(ABC) transporter
C6C15_RS15480	COG0423	glycine-tRNA ligase activity
C6C15_RS15485	COG3104	oligopeptide transport
C6C15_RS15500	COG0477	Major facilitator Superfamily
C6C15_RS15515	COG3590	peptidase
C6C15_RS15525	COG0534	Mate efflux family protein
C6C15_RS15550	COG1757	Na H antiporter
C6C15_RS15590	COG4948	Mandelate Racemase Muconate Lactonizing
C6C15_RS15595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C6C15_RS15600	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C6C15_RS15605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS15620	COG1737	Transcriptional regulator
C6C15_RS15640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6C15_RS15650	COG0561	phosphatase activity
C6C15_RS15655	COG2814	Major facilitator Superfamily
C6C15_RS15670	COG2197	response regulator
C6C15_RS15675	COG3135	benzoate transporter
C6C15_RS15680	COG4152	abc transporter atp-binding protein
C6C15_RS15685	COG1668	transmembrane transport
C6C15_RS15690	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS15695	COG0583	DNA-binding transcription factor activity
C6C15_RS15705	COG0542	response to heat
C6C15_RS15735	COG0438	transferase activity, transferring glycosyl groups
C6C15_RS15755	COG1609	Transcriptional regulator
C6C15_RS15770	COG1175	transmembrane transport
C6C15_RS15775	COG0395	ABC-type sugar transport system, permease component
C6C15_RS15815	COG1609	Transcriptional regulator
C6C15_RS15830	COG4948	Mandelate Racemase Muconate Lactonizing
C6C15_RS15835	COG3833	ABC-type maltose transport systems, permease component
C6C15_RS15855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6C15_RS15885	COG0395	ABC-type sugar transport system, permease component
C6C15_RS15890	COG1175	transmembrane transport
C6C15_RS15900	COG1215	transferase activity, transferring glycosyl groups
C6C15_RS15905	COG1366	Belongs to the anti-sigma-factor antagonist family
C6C15_RS15915	COG2259	Doxx family
C6C15_RS15920	COG1802	Transcriptional regulator
C6C15_RS15925	COG0789	Transcriptional regulator
C6C15_RS15930	COG0484	heat shock protein binding
C6C15_RS15935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6C15_RS15940	COG0443	Heat shock 70 kDa protein
C6C15_RS15955	COG0662	Cupin 2, conserved barrel domain protein
C6C15_RS15955	COG2207	Transcriptional regulator
C6C15_RS15960	COG2814	Major facilitator Superfamily
C6C15_RS15980	COG1228	amidohydrolase
C6C15_RS15980	COG1228	amidohydrolase
C6C15_RS15985	COG0477	Major facilitator Superfamily
C6C15_RS15995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6C15_RS16005	COG1175	transmembrane transport
C6C15_RS16015	COG1737	Transcriptional regulator
C6C15_RS16020	COG3876	Protein conserved in bacteria
C6C15_RS16065	COG0717	Belongs to the dCTP deaminase family
C6C15_RS16075	COG2409	Drug exporters of the RND superfamily
C6C15_RS16100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6C15_RS16105	COG0531	amino acid
C6C15_RS16115	COG0598	Magnesium transport protein CorA
C6C15_RS16130	COG5398	heme oxygenase
C6C15_RS16135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6C15_RS16150	COG0776	regulation of translation
C6C15_RS16155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6C15_RS16160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6C15_RS16165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6C15_RS16170	COG2094	Belongs to the DNA glycosylase MPG family
C6C15_RS16190	COG0701	Predicted permease
C6C15_RS16205	COG1121	(ABC) transporter
C6C15_RS16210	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6C15_RS16215	COG0366	Alpha amylase catalytic
C6C15_RS16220	COG0395	ABC-type sugar transport system, permease component
C6C15_RS16225	COG1175	transmembrane transport
C6C15_RS16240	COG0640	Transcriptional regulator
C6C15_RS16245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6C15_RS16250	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6C15_RS16255	COG0022	dehydrogenase e1 component
C6C15_RS16265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6C15_RS16275	COG3654	unkown
C6C15_RS16295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS16305	COG0477	Major facilitator Superfamily
C6C15_RS16330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6C15_RS16340	COG1396	sequence-specific DNA binding
C6C15_RS16345	COG0740	serine-type endopeptidase activity
C6C15_RS16350	COG0740	serine-type endopeptidase activity
C6C15_RS16355	COG1607	acyl-coa hydrolase
C6C15_RS16365	COG0626	cystathionine gamma-synthase activity
C6C15_RS16385	COG0534	Mate efflux family protein
C6C15_RS16390	COG1113	amino acid transport
C6C15_RS16400	COG2197	response regulator
C6C15_RS16405	COG4585	Histidine kinase
C6C15_RS16410	COG1739	Uncharacterized protein family UPF0029
C6C15_RS16430	COG0596	Alpha beta hydrolase
C6C15_RS16435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6C15_RS16440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6C15_RS16450	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C6C15_RS16455	COG1940	carbohydrate kinase activity
C6C15_RS16460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6C15_RS16465	COG4608	Belongs to the ABC transporter superfamily
C6C15_RS16470	COG0444	Belongs to the ABC transporter superfamily
C6C15_RS16475	COG0601	transmembrane transport
C6C15_RS16480	COG0747	negative chemotaxis
C6C15_RS16485	COG2186	Transcriptional regulator
C6C15_RS16490	COG2354	Protein conserved in bacteria
C6C15_RS16520	COG1349	DNA-binding transcription factor activity
C6C15_RS16540	COG0745	RESPONSE REGULATOR receiver
C6C15_RS16545	COG2205	protein histidine kinase activity
C6C15_RS16560	COG2501	S4 domain
C6C15_RS16585	COG0305	Participates in initiation and elongation during chromosome replication
C6C15_RS16610	COG0662	Cupin 2, conserved barrel domain protein
C6C15_RS16615	COG2843	Capsule synthesis protein
C6C15_RS16620	COG0359	binds to the 23S rRNA
C6C15_RS16625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6C15_RS16635	COG0360	Binds together with S18 to 16S ribosomal RNA
C6C15_RS16660	COG0444	Belongs to the ABC transporter superfamily
C6C15_RS16665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6C15_RS16670	COG0601	transmembrane transport
C6C15_RS16675	COG0747	negative chemotaxis
C6C15_RS16710	COG1028	Short-chain dehydrogenase reductase Sdr
C6C15_RS16725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6C15_RS16740	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS16790	COG1522	sequence-specific DNA binding
C6C15_RS16795	COG1012	belongs to the aldehyde dehydrogenase family
C6C15_RS16800	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6C15_RS16815	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6C15_RS16855	COG2890	protein-(glutamine-N5) methyltransferase activity
C6C15_RS16870	COG0492	ferredoxin-NADP+ reductase activity
C6C15_RS16875	COG3118	belongs to the thioredoxin family
C6C15_RS16890	COG0477	Major facilitator Superfamily
C6C15_RS16900	COG1192	Involved in chromosome partitioning
C6C15_RS16905	COG0357	Ribosomal RNA small subunit methyltransferase G
C6C15_RS16915	COG0706	membrane insertase activity
C6C15_RS16920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6C15_RS16930	COG0230	Belongs to the bacterial ribosomal protein bL34 family