locus-tag	class	description
AUP74_RS00015	COG1137	ATPase activity
AUP74_RS00020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AUP74_RS00035	COG1660	Displays ATPase and GTPase activities
AUP74_RS00045	COG2239	Acts as a magnesium transporter
AUP74_RS00060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUP74_RS00075	COG0424	maF-like protein
AUP74_RS00085	COG1792	Involved in formation and maintenance of cell shape
AUP74_RS00090	COG1077	Cell shape determining protein MreB Mrl
AUP74_RS00095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AUP74_RS00100	COG0154	amidase activity
AUP74_RS00105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AUP74_RS00120	COG2755	lipolytic protein G-D-S-L family
AUP74_RS00120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AUP74_RS00140	COG0534	Mate efflux family protein
AUP74_RS00145	COG3608	succinylglutamate desuccinylase aspartoacylase
AUP74_RS00150	COG1230	cation diffusion facilitator family transporter
AUP74_RS00155	COG2890	protein-(glutamine-N5) methyltransferase activity
AUP74_RS00160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AUP74_RS00165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AUP74_RS00175	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AUP74_RS00180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AUP74_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AUP74_RS00195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AUP74_RS00200	COG0193	aminoacyl-tRNA hydrolase activity
AUP74_RS00250	COG0469	pyruvate kinase activity
AUP74_RS00255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AUP74_RS00260	COG0800	Aldolase
AUP74_RS00270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AUP74_RS00275	COG0129	dihydroxy-acid dehydratase activity
AUP74_RS00280	COG0166	Belongs to the GPI family
AUP74_RS00285	COG1609	Transcriptional regulator
AUP74_RS00290	COG0738	Major facilitator superfamily
AUP74_RS00295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AUP74_RS00305	COG2971	BadF BadG BcrA BcrD
AUP74_RS00310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AUP74_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AUP74_RS00330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUP74_RS00360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AUP74_RS00365	COG1702	phosphate starvation-inducible protein PhoH
AUP74_RS00370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AUP74_RS00380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AUP74_RS00390	COG1090	epimerase
AUP74_RS00410	COG0495	leucyl-tRNA aminoacylation
AUP74_RS00425	COG1466	dna polymerase III delta subunit
AUP74_RS00430	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS00450	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AUP74_RS00465	COG0288	reversible hydration of carbon dioxide
AUP74_RS00470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AUP74_RS00475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AUP74_RS00480	COG0584	glycerophosphoryl diester phosphodiesterase
AUP74_RS00490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AUP74_RS00530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AUP74_RS00535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AUP74_RS00550	COG0745	RESPONSE REGULATOR receiver
AUP74_RS00555	COG2853	Lipoprotein
AUP74_RS00565	COG3220	belongs to the UPF0276 family
AUP74_RS00575	COG1643	Atp-dependent helicase
AUP74_RS00580	COG3104	oligopeptide transport
AUP74_RS00590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AUP74_RS00605	COG2983	Belongs to the UPF0260 family
AUP74_RS00610	COG3100	YcgL domain-containing protein
AUP74_RS00620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AUP74_RS00625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AUP74_RS00630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AUP74_RS00645	COG4206	TonB-dependent receptor
AUP74_RS00685	COG0457	Tetratricopeptide repeat
AUP74_RS00695	COG2095	MarC family integral membrane protein
AUP74_RS00715	COG3104	oligopeptide transport
AUP74_RS00720	COG0730	response to heat
AUP74_RS00740	COG1560	Kdo2-lipid A biosynthetic process
AUP74_RS00760	COG0667	Aldo Keto reductase
AUP74_RS00765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AUP74_RS00775	COG0589	response to stress
AUP74_RS00780	COG0659	secondary active sulfate transmembrane transporter activity
AUP74_RS00785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS00790	COG1136	(ABC) transporter
AUP74_RS00795	COG1136	(ABC) transporter
AUP74_RS00795	COG0577	efflux transmembrane transporter activity
AUP74_RS00800	COG0577	efflux transmembrane transporter activity
AUP74_RS00805	COG2204	response regulator
AUP74_RS00810	COG5002	protein histidine kinase activity
AUP74_RS00830	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUP74_RS00855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AUP74_RS00865	COG0425	Belongs to the sulfur carrier protein TusA family
AUP74_RS00875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AUP74_RS00890	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AUP74_RS00895	COG0602	queuosine metabolic process
AUP74_RS00905	COG2885	chlorophyll binding
AUP74_RS00910	COG0823	Involved in the tonB-independent uptake of proteins
AUP74_RS00930	COG0824	Thioesterase
AUP74_RS00935	COG2255	four-way junction helicase activity
AUP74_RS00940	COG0632	four-way junction helicase activity
AUP74_RS00945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AUP74_RS00965	COG2867	negative regulation of translational initiation
AUP74_RS00970	COG0733	neurotransmitter:sodium symporter activity
AUP74_RS00975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AUP74_RS00980	COG0733	neurotransmitter:sodium symporter activity
AUP74_RS00995	COG0583	DNA-binding transcription factor activity
AUP74_RS01000	COG1073	alpha beta
AUP74_RS01005	COG1073	alpha beta
AUP74_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS01020	COG3119	arylsulfatase activity
AUP74_RS01025	COG1649	PFAM Uncharacterised BCR, COG1649
AUP74_RS01040	COG4221	oxidoreductase activity
AUP74_RS01045	COG0564	pseudouridine synthase activity
AUP74_RS01055	COG0577	efflux transmembrane transporter activity
AUP74_RS01055	COG1136	(ABC) transporter
AUP74_RS01075	COG1136	(ABC) transporter
AUP74_RS01080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AUP74_RS01080	COG2111	Na H antiporter
AUP74_RS01085	COG2111	Na H antiporter
AUP74_RS01090	COG1006	Multisubunit Na H antiporter MnhC subunit
AUP74_RS01095	COG0651	ATP synthesis coupled electron transport
AUP74_RS01100	COG1863	multisubunit Na H antiporter MnhE subunit
AUP74_RS01105	COG2212	antiporter activity
AUP74_RS01110	COG1320	monovalent cation:proton antiporter activity
AUP74_RS01120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AUP74_RS01125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AUP74_RS01130	COG2270	Major facilitator Superfamily
AUP74_RS01145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AUP74_RS01155	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUP74_RS01160	COG4771	TonB-dependent receptor
AUP74_RS01165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AUP74_RS01170	COG2271	Major facilitator Superfamily
AUP74_RS01190	COG0385	Bile acid
AUP74_RS01205	COG1271	oxidase subunit
AUP74_RS01210	COG1294	oxidase, subunit
AUP74_RS01220	COG1858	cytochrome C peroxidase
AUP74_RS01265	COG4773	Receptor
AUP74_RS01280	COG0668	transmembrane transport
AUP74_RS01295	COG1741	Belongs to the pirin family
AUP74_RS01330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AUP74_RS01340	COG2824	Alkylphosphonate utilization operon protein PhnA
AUP74_RS01345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AUP74_RS01360	COG5622	Protein required for attachment to host cells
AUP74_RS01375	COG3038	cytochrome b561
AUP74_RS01380	COG2353	YceI-like domain
AUP74_RS01390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AUP74_RS01400	COG0527	aspartate kinase activity
AUP74_RS01405	COG1917	Cupin 2, conserved barrel domain protein
AUP74_RS01435	COG2815	serine threonine protein kinase
AUP74_RS01435	COG0515	serine threonine protein kinase
AUP74_RS01450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AUP74_RS01460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AUP74_RS01470	COG1181	Belongs to the D-alanine--D-alanine ligase family
AUP74_RS01490	COG0142	geranyltranstransferase activity
AUP74_RS01495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AUP74_RS01510	COG1162	GTPase activity
AUP74_RS01520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AUP74_RS01530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AUP74_RS01535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AUP74_RS01540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AUP74_RS01545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AUP74_RS01560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AUP74_RS01560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AUP74_RS01565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AUP74_RS01580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AUP74_RS01630	COG0488	(ABC) transporter
AUP74_RS01655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AUP74_RS01655	COG0519	Catalyzes the synthesis of GMP from XMP
AUP74_RS01660	COG3047	cAMP biosynthetic process
AUP74_RS01685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AUP74_RS01695	COG2197	response regulator
AUP74_RS01700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AUP74_RS01735	COG2217	Heavy metal translocating P-type atpase
AUP74_RS01740	COG0701	Predicted permease
AUP74_RS01780	COG2095	MarC family integral membrane protein
AUP74_RS01785	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AUP74_RS01795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AUP74_RS01800	COG0248	Ppx GppA phosphatase
AUP74_RS01805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AUP74_RS01815	COG2814	Major facilitator Superfamily
AUP74_RS01850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AUP74_RS01855	COG0390	transport system, permease component
AUP74_RS01860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AUP74_RS01870	COG0709	Synthesizes selenophosphate from selenide and ATP
AUP74_RS01875	COG1252	NADH dehydrogenase
AUP74_RS01900	COG3273	potassium ion transport
AUP74_RS01900	COG0471	metal ion transport
AUP74_RS01905	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AUP74_RS01910	COG0300	oxidoreductase activity
AUP74_RS01925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AUP74_RS01945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUP74_RS01960	COG0366	Alpha amylase catalytic
AUP74_RS01970	COG1115	amino acid carrier protein
AUP74_RS01980	COG0366	Alpha amylase catalytic
AUP74_RS01985	COG1501	Belongs to the glycosyl hydrolase 31 family
AUP74_RS02010	COG0642	Histidine kinase
AUP74_RS02050	COG0589	response to stress
AUP74_RS02055	COG0366	Alpha amylase catalytic
AUP74_RS02085	COG0837	glucose binding
AUP74_RS02090	COG3833	ABC-type maltose transport systems, permease component
AUP74_RS02095	COG1175	transmembrane transport
AUP74_RS02100	COG3842	ATPase activity
AUP74_RS02110	COG1473	amidohydrolase
AUP74_RS02115	COG0513	Belongs to the DEAD box helicase family
AUP74_RS02150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AUP74_RS02155	COG3151	Protein conserved in bacteria
AUP74_RS02160	COG0494	nUDIX hydrolase
AUP74_RS02175	COG3008	intermembrane lipid transfer
AUP74_RS02180	COG2995	paraquat-inducible protein a
AUP74_RS02185	COG2995	paraquat-inducible protein a
AUP74_RS02190	COG1538	Outer membrane efflux protein
AUP74_RS02195	COG1519	Transferase
AUP74_RS02200	COG1215	transferase activity, transferring glycosyl groups
AUP74_RS02210	COG0515	serine threonine protein kinase
AUP74_RS02220	COG0438	transferase activity, transferring glycosyl groups
AUP74_RS02255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AUP74_RS02260	COG1392	Phosphate transport regulator
AUP74_RS02265	COG0306	phosphate transporter
AUP74_RS02295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AUP74_RS02295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AUP74_RS02300	COG0129	dihydroxy-acid dehydratase activity
AUP74_RS02305	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AUP74_RS02320	COG0848	biopolymer transport protein
AUP74_RS02330	COG0811	peptide transport
AUP74_RS02345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AUP74_RS02350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AUP74_RS02375	COG3108	Peptidase M15
AUP74_RS02390	COG0494	nUDIX hydrolase
AUP74_RS02395	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AUP74_RS02400	COG0509	glycine decarboxylation via glycine cleavage system
AUP74_RS02405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AUP74_RS02425	COG1253	flavin adenine dinucleotide binding
AUP74_RS02435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AUP74_RS02440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AUP74_RS02445	COG0006	proline dipeptidase activity
AUP74_RS02450	COG3079	Belongs to the UPF0149 family
AUP74_RS02470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AUP74_RS02475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AUP74_RS02480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AUP74_RS02510	COG0183	Belongs to the thiolase family
AUP74_RS02520	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS02525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AUP74_RS02530	COG0415	Belongs to the DNA photolyase family
AUP74_RS02535	COG3046	protein related to deoxyribodipyrimidine photolyase
AUP74_RS02540	COG4628	conserved protein (DUF2132)
AUP74_RS02555	COG1132	(ABC) transporter
AUP74_RS02575	COG0531	amino acid
AUP74_RS02590	COG1278	Cold shock
AUP74_RS02600	COG2252	PERMEase
AUP74_RS02610	COG2815	serine threonine protein kinase
AUP74_RS02610	COG0515	serine threonine protein kinase
AUP74_RS02625	COG4774	siderophore transport
AUP74_RS02705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AUP74_RS02730	COG0457	Tetratricopeptide repeat
AUP74_RS02735	COG4771	TonB-dependent receptor
AUP74_RS02760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AUP74_RS02765	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS02785	COG2819	hydrolase of the alpha beta superfamily
AUP74_RS02810	COG0189	ligase activity
AUP74_RS02825	COG0861	Integral membrane protein TerC family
AUP74_RS02850	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS02860	COG0179	Fumarylacetoacetate (FAA) hydrolase
AUP74_RS02865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AUP74_RS02870	COG2962	Rard protein
AUP74_RS02885	COG0126	phosphoglycerate kinase activity
AUP74_RS02900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AUP74_RS02910	COG0612	Peptidase, M16
AUP74_RS02955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AUP74_RS02970	COG3148	PFAM DTW domain containing protein
AUP74_RS02975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AUP74_RS02980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AUP74_RS02990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AUP74_RS02995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AUP74_RS03000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AUP74_RS03020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AUP74_RS03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS03035	COG2183	response to ionizing radiation
AUP74_RS03045	COG2207	Transcriptional regulator
AUP74_RS03065	COG2808	Putative FMN-binding domain
AUP74_RS03070	COG1233	COG1233 Phytoene dehydrogenase and related
AUP74_RS03075	COG1764	response to oxidative stress
AUP74_RS03080	COG0010	Belongs to the arginase family
AUP74_RS03085	COG1228	amidohydrolase
AUP74_RS03090	COG2188	Transcriptional regulator
AUP74_RS03100	COG2986	histidine ammonia-lyase
AUP74_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS03125	COG0318	PFAM AMP-dependent synthetase and ligase
AUP74_RS03130	COG1024	Enoyl-CoA hydratase
AUP74_RS03140	COG0657	acetylesterase activity
AUP74_RS03150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AUP74_RS03150	COG2205	protein histidine kinase activity
AUP74_RS03180	COG0300	oxidoreductase activity
AUP74_RS03190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AUP74_RS03200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AUP74_RS03205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AUP74_RS03210	COG4942	peptidase
AUP74_RS03215	COG0793	Belongs to the peptidase S41A family
AUP74_RS03225	COG0107	imidazoleglycerol-phosphate synthase activity
AUP74_RS03230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AUP74_RS03235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AUP74_RS03240	COG0131	Imidazoleglycerol-phosphate dehydratase
AUP74_RS03260	COG1194	a g-specific adenine glycosylase
AUP74_RS03265	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AUP74_RS03300	COG0582	viral genome integration into host DNA
AUP74_RS03340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AUP74_RS03410	COG2801	Transposase and inactivated derivatives
AUP74_RS03420	COG1902	pentaerythritol trinitrate reductase activity
AUP74_RS03425	COG0789	Transcriptional regulator
AUP74_RS03440	COG2197	response regulator
AUP74_RS03485	COG1218	3'(2'),5'-bisphosphate nucleotidase
AUP74_RS03500	COG1011	Hydrolase
AUP74_RS03505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AUP74_RS03510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AUP74_RS03520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AUP74_RS03525	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AUP74_RS03540	COG0628	permease
AUP74_RS03565	COG2204	response regulator
AUP74_RS03580	COG0174	glutamine synthetase
AUP74_RS03585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AUP74_RS03585	COG0301	tRNA thio-modification
AUP74_RS03605	COG2205	protein histidine kinase activity
AUP74_RS03615	COG1217	gtp-binding protein TYPA
AUP74_RS03620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AUP74_RS03625	COG3706	GGDEF domain
AUP74_RS03655	COG2133	pyrroloquinoline quinone binding
AUP74_RS03665	COG1285	pathogenesis
AUP74_RS03670	COG0668	transmembrane transport
AUP74_RS03675	COG2818	Glycosylase
AUP74_RS03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AUP74_RS03685	COG1505	serine-type exopeptidase activity
AUP74_RS03690	COG1490	D-aminoacyl-tRNA deacylase activity
AUP74_RS03725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AUP74_RS03730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AUP74_RS03735	COG0140	phosphoribosyl-ATP diphosphatase activity
AUP74_RS03740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AUP74_RS03745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AUP74_RS03755	COG2226	methyltransferase
AUP74_RS03760	COG4771	TonB-dependent receptor
AUP74_RS03775	COG0330	HflC and HflK could
AUP74_RS03800	COG4771	TonB-dependent receptor
AUP74_RS03820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AUP74_RS03825	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AUP74_RS03840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AUP74_RS03845	COG0254	rRNA binding
AUP74_RS03855	COG0281	malic enzyme
AUP74_RS03865	COG2918	glutathione biosynthetic process
AUP74_RS03870	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AUP74_RS03875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AUP74_RS03880	COG1380	Effector of murein hydrolase LrgA
AUP74_RS03885	COG1346	cytolysis
AUP74_RS03910	COG0488	(ABC) transporter
AUP74_RS03920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AUP74_RS03925	COG2363	Small membrane protein
AUP74_RS03935	COG2177	Part of the ABC transporter FtsEX involved in
AUP74_RS03940	COG2884	Cell division ATP-binding protein ftsE
AUP74_RS03945	COG0552	protein localization to endoplasmic reticulum
AUP74_RS03950	COG0742	ribosomal rna small subunit methyltransferase
AUP74_RS03955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AUP74_RS03975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AUP74_RS03980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AUP74_RS03985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AUP74_RS03990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AUP74_RS03995	COG2003	Belongs to the UPF0758 family
AUP74_RS04000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AUP74_RS04005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AUP74_RS04010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AUP74_RS04015	COG1309	transcriptional regulator
AUP74_RS04025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AUP74_RS04030	COG0708	Exodeoxyribonuclease III
AUP74_RS04035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AUP74_RS04040	COG1561	YicC-like family, N-terminal region
AUP74_RS04045	COG1404	Belongs to the peptidase S8 family
AUP74_RS04065	COG1064	alcohol dehydrogenase
AUP74_RS04075	COG1309	transcriptional regulator
AUP74_RS04085	COG0194	GDP metabolic process
AUP74_RS04090	COG1758	RNA polymerase activity
AUP74_RS04095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AUP74_RS04110	COG2261	transglycosylase associated protein
AUP74_RS04115	COG0583	DNA-binding transcription factor activity
AUP74_RS04120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AUP74_RS04135	COG1301	dicarboxylic acid transport
AUP74_RS04140	COG3161	chorismate lyase activity
AUP74_RS04145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AUP74_RS04170	COG3022	response to hydroperoxide
AUP74_RS04180	COG4783	chaperone-mediated protein folding
AUP74_RS04195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AUP74_RS04205	COG0573	inorganic phosphate transmembrane transporter activity
AUP74_RS04220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AUP74_RS04235	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS04240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS04265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AUP74_RS04275	COG0210	DNA helicase
AUP74_RS04280	COG1737	Transcriptional regulator
AUP74_RS04285	COG2814	Major facilitator Superfamily
AUP74_RS04295	COG0435	Glutathione S-transferase
AUP74_RS04300	COG2259	Doxx family
AUP74_RS04305	COG0583	DNA-binding transcription factor activity
AUP74_RS04310	COG1741	Belongs to the pirin family
AUP74_RS04330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AUP74_RS04335	COG1349	DNA-binding transcription factor activity
AUP74_RS04355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AUP74_RS04360	COG0402	S-adenosylhomocysteine deaminase activity
AUP74_RS04370	COG2116	formate transmembrane transporter activity
AUP74_RS04385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AUP74_RS04390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AUP74_RS04395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AUP74_RS04400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AUP74_RS04405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AUP74_RS04410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AUP74_RS04420	COG0356	it plays a direct role in the translocation of protons across the membrane
AUP74_RS04430	COG1475	DNA binding
AUP74_RS04435	COG1192	Involved in chromosome partitioning
AUP74_RS04440	COG0357	Ribosomal RNA small subunit methyltransferase G
AUP74_RS04445	COG0445	tRNA wobble uridine modification
AUP74_RS04450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AUP74_RS04455	COG0706	membrane insertase activity
AUP74_RS04460	COG0594	ribonuclease P activity
AUP74_RS04465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AUP74_RS04470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AUP74_RS04475	COG0592	DNA-directed DNA polymerase activity
AUP74_RS04480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AUP74_RS04490	COG0175	sulfate reduction
AUP74_RS04510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AUP74_RS04525	COG0751	glycine-tRNA ligase activity
AUP74_RS04530	COG0752	glycyl-tRNA synthetase alpha subunit
AUP74_RS04540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AUP74_RS04550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AUP74_RS04555	COG0569	domain protein
AUP74_RS04565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AUP74_RS04570	COG0242	peptide deformylase activity
AUP74_RS04575	COG1652	LysM domain
AUP74_RS04580	COG0758	DNA mediated transformation
AUP74_RS04590	COG0009	L-threonylcarbamoyladenylate synthase
AUP74_RS04605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AUP74_RS04615	COG2235	arginine
AUP74_RS04635	COG0531	amino acid
AUP74_RS04645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AUP74_RS04655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AUP74_RS04680	COG0534	Mate efflux family protein
AUP74_RS04685	COG1565	acr, cog1565
AUP74_RS04685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AUP74_RS04690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AUP74_RS04695	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AUP74_RS04720	COG1612	heme a metabolic process
AUP74_RS04725	COG0109	protoheme IX farnesyltransferase activity
AUP74_RS04765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AUP74_RS04770	COG1121	(ABC) transporter
AUP74_RS04805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AUP74_RS04815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AUP74_RS04855	COG0471	metal ion transport
AUP74_RS04860	COG2234	aminopeptidase activity
AUP74_RS04890	COG3040	lipid binding
AUP74_RS04915	COG0714	Associated with various cellular activities
AUP74_RS04960	COG2268	Band 7 protein
AUP74_RS04975	COG0789	Transcriptional regulator
AUP74_RS05050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AUP74_RS05065	COG3206	protein involved in exopolysaccharide biosynthesis
AUP74_RS05065	COG0489	protein tyrosine kinase activity
AUP74_RS05070	COG4464	protein tyrosine phosphatase activity
AUP74_RS05100	COG3119	arylsulfatase activity
AUP74_RS05105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AUP74_RS05115	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AUP74_RS05120	COG2188	Transcriptional regulator
AUP74_RS05135	COG1175	transmembrane transport
AUP74_RS05140	COG0395	ABC-type sugar transport system, permease component
AUP74_RS05145	COG0383	alpha-mannosidase activity
AUP74_RS05170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AUP74_RS05185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AUP74_RS05190	COG0471	metal ion transport
AUP74_RS05260	COG1136	(ABC) transporter
AUP74_RS05295	COG1944	ATP diphosphatase activity
AUP74_RS05305	COG0612	Peptidase, M16
AUP74_RS05310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AUP74_RS05325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AUP74_RS05350	COG5492	domain, Protein
AUP74_RS05350	COG4932	domain protein
AUP74_RS05355	COG0210	DNA helicase
AUP74_RS05365	COG1671	Belongs to the UPF0178 family
AUP74_RS05385	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AUP74_RS05420	COG0004	ammonium transporteR
AUP74_RS05425	COG0347	Belongs to the P(II) protein family
AUP74_RS05450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AUP74_RS05465	COG1965	Belongs to the frataxin family
AUP74_RS05470	COG0165	Argininosuccinate lyase
AUP74_RS05475	COG0745	RESPONSE REGULATOR receiver
AUP74_RS05475	COG2972	Histidine kinase
AUP74_RS05520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AUP74_RS05525	COG2813	Specifically methylates the guanine in position
AUP74_RS05525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AUP74_RS05540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AUP74_RS05555	COG0724	RNA recognition motif
AUP74_RS05560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AUP74_RS05615	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AUP74_RS05640	COG0457	Tetratricopeptide repeat
AUP74_RS05670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AUP74_RS05675	COG1678	Uncharacterized ACR, COG1678
AUP74_RS05685	COG0189	ligase activity
AUP74_RS05705	COG0840	transmembrane signaling receptor activity
AUP74_RS05710	COG0643	Histidine kinase
AUP74_RS05710	COG0643	Histidine kinase
AUP74_RS05710	COG2198	Histidine kinase
AUP74_RS05710	COG0784	Response regulator, receiver
AUP74_RS05710	COG2198	Histidine kinase
AUP74_RS05710	COG0784	Response regulator, receiver
AUP74_RS05755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AUP74_RS05760	COG0067	glutamate synthase
AUP74_RS05760	COG0069	glutamate synthase activity
AUP74_RS05760	COG0070	glutamate synthase
AUP74_RS05765	COG0493	'glutamate synthase
AUP74_RS05770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AUP74_RS05775	COG3437	response regulator, receiver
AUP74_RS05780	COG0688	phosphatidylethanolamine metabolic process
AUP74_RS05790	COG1162	GTPase activity
AUP74_RS05795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AUP74_RS05805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AUP74_RS05805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AUP74_RS05810	COG0802	atpase or kinase
AUP74_RS05820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AUP74_RS05825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AUP74_RS05830	COG1923	regulation of RNA biosynthetic process
AUP74_RS05835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AUP74_RS05840	COG0330	HflC and HflK could
AUP74_RS05845	COG0330	HflC and HflK could
AUP74_RS05850	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AUP74_RS05855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AUP74_RS05860	COG1272	protein, Hemolysin III
AUP74_RS05865	COG2951	lytic endotransglycosylase activity
AUP74_RS05880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AUP74_RS05885	COG1238	metal cluster binding
AUP74_RS05915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AUP74_RS05930	COG0557	exoribonuclease II activity
AUP74_RS05935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AUP74_RS05945	COG0360	Binds together with S18 to 16S ribosomal RNA
AUP74_RS05950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AUP74_RS05960	COG0359	binds to the 23S rRNA
AUP74_RS05965	COG0305	Participates in initiation and elongation during chromosome replication
AUP74_RS05975	COG0010	Belongs to the arginase family
AUP74_RS05990	COG1166	arginine decarboxylase activity
AUP74_RS06000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AUP74_RS06010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AUP74_RS06020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AUP74_RS06035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AUP74_RS06040	COG1045	serine acetyltransferase
AUP74_RS06055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AUP74_RS06060	COG1509	lysine 2,3-aminomutase activity
AUP74_RS06085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS06090	COG0560	Phosphoserine phosphatase
AUP74_RS06100	COG0789	Transcriptional regulator
AUP74_RS06105	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS06110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AUP74_RS06115	COG1024	Enoyl-CoA hydratase
AUP74_RS06120	COG4770	biotin carboxylase activity
AUP74_RS06155	COG1040	competence protein
AUP74_RS06160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AUP74_RS06165	COG0156	8-amino-7-oxononanoate synthase activity
AUP74_RS06170	COG1073	alpha beta
AUP74_RS06170	COG2226	methyltransferase
AUP74_RS06185	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS06210	COG2972	Histidine kinase
AUP74_RS06225	COG3264	Mechanosensitive ion channel
AUP74_RS06225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AUP74_RS06240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AUP74_RS06250	COG3152	Membrane
AUP74_RS06255	COG3128	pkhd-type hydroxylase
AUP74_RS06260	COG4774	siderophore transport
AUP74_RS06290	COG0582	viral genome integration into host DNA
AUP74_RS06310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AUP74_RS06315	COG0358	DNA primase activity
AUP74_RS06320	COG1610	YqeY-like protein
AUP74_RS06325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AUP74_RS06330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AUP74_RS06335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AUP74_RS06340	COG0302	gtp cyclohydrolase
AUP74_RS06340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AUP74_RS06355	COG2205	protein histidine kinase activity
AUP74_RS06360	COG0745	RESPONSE REGULATOR receiver
AUP74_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS06375	COG0745	RESPONSE REGULATOR receiver
AUP74_RS06380	COG2719	SpoVR family
AUP74_RS06390	COG2766	serine protein kinase
AUP74_RS06395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AUP74_RS06405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AUP74_RS06410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AUP74_RS06415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AUP74_RS06420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AUP74_RS06425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AUP74_RS06430	COG3178	'Phosphotransferase
AUP74_RS06435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AUP74_RS06440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AUP74_RS06460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AUP74_RS06465	COG0134	indole-3-glycerol-phosphate synthase activity
AUP74_RS06475	COG1765	OsmC-like protein
AUP74_RS06480	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AUP74_RS06485	COG0151	Belongs to the GarS family
AUP74_RS06490	COG0138	bifunctional purine biosynthesis protein purh
AUP74_RS06495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AUP74_RS06510	COG2264	protein methyltransferase activity
AUP74_RS06525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AUP74_RS06550	COG5001	Diguanylate cyclase
AUP74_RS06550	COG5002	protein histidine kinase activity
AUP74_RS06555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AUP74_RS06560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AUP74_RS06575	COG1733	regulation of RNA biosynthetic process
AUP74_RS06580	COG2249	NAD(P)H dehydrogenase (quinone) activity
AUP74_RS06600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AUP74_RS06610	COG1981	membrane
AUP74_RS06620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AUP74_RS06635	COG0316	Belongs to the HesB IscA family
AUP74_RS06640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AUP74_RS06645	COG0739	heme binding
AUP74_RS06650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AUP74_RS06680	COG4989	oxidoreductase activity
AUP74_RS06695	COG1131	(ABC) transporter
AUP74_RS06700	COG1668	transmembrane transport
AUP74_RS06705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AUP74_RS06710	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AUP74_RS06710	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AUP74_RS06745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AUP74_RS06765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AUP74_RS06770	COG0081	regulation of translation
AUP74_RS06780	COG0222	ribosome binding
AUP74_RS06785	COG0085	RNA polymerase activity
AUP74_RS06790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AUP74_RS06795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AUP74_RS06800	COG0049	tRNA binding
AUP74_RS06805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AUP74_RS06810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AUP74_RS06820	COG0051	transcription antitermination factor activity, RNA binding
AUP74_RS06825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AUP74_RS06830	COG0088	Forms part of the polypeptide exit tunnel
AUP74_RS06835	COG0089	rRNA binding
AUP74_RS06840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AUP74_RS06845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AUP74_RS06850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AUP74_RS06855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AUP74_RS06860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AUP74_RS06865	COG0255	Belongs to the universal ribosomal protein uL29 family
AUP74_RS06870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AUP74_RS06875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AUP74_RS06880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AUP74_RS06885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AUP74_RS06890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AUP74_RS06895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AUP74_RS06900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AUP74_RS06905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AUP74_RS06910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AUP74_RS06915	COG1841	ribosomal large subunit assembly
AUP74_RS06920	COG0200	Binds to the 23S rRNA
AUP74_RS06930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AUP74_RS06935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AUP74_RS06940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AUP74_RS06945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AUP74_RS06950	COG0202	RNA polymerase activity
AUP74_RS06955	COG0203	ribosomal protein L17
AUP74_RS06960	COG3139	Protein of unknown function (DUF1315)
AUP74_RS06980	COG1914	H( )-stimulated, divalent metal cation uptake system
AUP74_RS06990	COG2814	Major facilitator Superfamily
AUP74_RS06995	COG0629	single-stranded DNA binding
AUP74_RS07010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AUP74_RS07020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AUP74_RS07025	COG0142	geranyltranstransferase activity
AUP74_RS07030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AUP74_RS07035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AUP74_RS07040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AUP74_RS07045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AUP74_RS07050	COG0268	Binds directly to 16S ribosomal RNA
AUP74_RS07055	COG2205	protein histidine kinase activity
AUP74_RS07060	COG0745	RESPONSE REGULATOR receiver
AUP74_RS07070	COG0728	peptidoglycan biosynthetic process
AUP74_RS07075	COG0196	riboflavin kinase activity
AUP74_RS07080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AUP74_RS07090	COG1047	Peptidyl-prolyl cis-trans
AUP74_RS07095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AUP74_RS07125	COG4969	Belongs to the N-Me-Phe pilin family
AUP74_RS07170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AUP74_RS07170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AUP74_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS07200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS07205	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AUP74_RS07215	COG0028	Belongs to the TPP enzyme family
AUP74_RS07225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AUP74_RS07230	COG1183	phosphatidylcholine synthase activity
AUP74_RS07310	COG0672	)-iron permease
AUP74_RS07315	COG0386	Belongs to the glutathione peroxidase family
AUP74_RS07320	COG1846	Transcriptional regulator
AUP74_RS07325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AUP74_RS07340	COG0534	Mate efflux family protein
AUP74_RS07350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AUP74_RS07370	COG4935	Belongs to the peptidase S8 family
AUP74_RS07370	COG2234	aminopeptidase activity
AUP74_RS07430	COG0456	acetyltransferase
AUP74_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS07450	COG0430	RNA-3'-phosphate cyclase activity
AUP74_RS07460	COG0477	Major facilitator Superfamily
AUP74_RS07470	COG1476	TRANSCRIPTIONal
AUP74_RS07475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AUP74_RS07490	COG3590	peptidase
AUP74_RS07510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS07535	COG1803	Methylglyoxal synthase
AUP74_RS07540	COG0848	biopolymer transport protein
AUP74_RS07545	COG3483	tryptophan 2,3-dioxygenase activity
AUP74_RS07550	COG1024	Enoyl-CoA hydratase
AUP74_RS07565	COG0393	Putative heavy-metal-binding
AUP74_RS07580	COG0584	glycerophosphoryl diester phosphodiesterase
AUP74_RS07630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AUP74_RS07660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AUP74_RS07685	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AUP74_RS07690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AUP74_RS07700	COG4660	Part of a membrane complex involved in electron transport
AUP74_RS07705	COG4659	FMN binding
AUP74_RS07710	COG4658	electron transport chain
AUP74_RS07720	COG2878	Part of a membrane complex involved in electron transport
AUP74_RS07725	COG4657	Part of a membrane complex involved in electron transport
AUP74_RS07740	COG0625	glutathione transferase activity
AUP74_RS07750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AUP74_RS07785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AUP74_RS07790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AUP74_RS07790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AUP74_RS07795	COG0489	protein tyrosine kinase activity
AUP74_RS07800	COG1054	Belongs to the UPF0176 family
AUP74_RS07825	COG0247	lactate metabolic process
AUP74_RS07825	COG0277	FAD linked oxidase domain protein
AUP74_RS07835	COG0789	Transcriptional regulator
AUP74_RS07840	COG0415	Belongs to the DNA photolyase family
AUP74_RS07845	COG3240	lipase activity
AUP74_RS07845	COG4625	pathogenesis
AUP74_RS07855	COG1522	sequence-specific DNA binding
AUP74_RS07905	COG0442	prolyl-tRNA aminoacylation
AUP74_RS07910	COG0776	regulation of translation
AUP74_RS07920	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AUP74_RS07935	COG0497	DNA recombination
AUP74_RS07940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AUP74_RS07945	COG0443	Heat shock 70 kDa protein
AUP74_RS07950	COG0484	heat shock protein binding
AUP74_RS07965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AUP74_RS07970	COG0189	ligase activity
AUP74_RS07970	COG4067	protein conserved in archaea
AUP74_RS07980	COG0505	Belongs to the CarA family
AUP74_RS07985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AUP74_RS08000	COG1131	(ABC) transporter
AUP74_RS08005	COG0842	Transport permease protein
AUP74_RS08010	COG2197	response regulator
AUP74_RS08020	COG0584	glycerophosphoryl diester phosphodiesterase
AUP74_RS08025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUP74_RS08030	COG0842	Transport permease protein
AUP74_RS08035	COG1131	(ABC) transporter
AUP74_RS08040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AUP74_RS08045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AUP74_RS08065	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AUP74_RS08075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AUP74_RS08080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AUP74_RS08085	COG0149	triose-phosphate isomerase activity
AUP74_RS08090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AUP74_RS08125	COG0811	peptide transport
AUP74_RS08185	COG0779	Required for maturation of 30S ribosomal subunits
AUP74_RS08190	COG0195	Participates in both transcription termination and antitermination
AUP74_RS08195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AUP74_RS08200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AUP74_RS08205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AUP74_RS08210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AUP74_RS08215	COG1185	polyribonucleotide nucleotidyltransferase activity
AUP74_RS08250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AUP74_RS08255	COG1428	Deoxynucleoside kinase
AUP74_RS08275	COG3852	Histidine kinase
AUP74_RS08285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AUP74_RS08290	COG1489	DNA binding
AUP74_RS08305	COG0501	Belongs to the peptidase M48B family
AUP74_RS08320	COG1045	serine acetyltransferase
AUP74_RS08330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AUP74_RS08335	COG0174	glutamine synthetase
AUP74_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS08350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUP74_RS08350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUP74_RS08355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AUP74_RS08360	COG0205	6-phosphofructokinase activity
AUP74_RS08365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AUP74_RS08400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AUP74_RS08405	COG2321	neutral zinc metallopeptidase
AUP74_RS08415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AUP74_RS08420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AUP74_RS08430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AUP74_RS08435	COG0768	penicillin binding
AUP74_RS08440	COG0772	Belongs to the SEDS family
AUP74_RS08445	COG2951	lytic endotransglycosylase activity
AUP74_RS08455	COG1686	Belongs to the peptidase S11 family
AUP74_RS08470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AUP74_RS08505	COG3279	Response regulator of the LytR AlgR family
AUP74_RS08510	COG2972	Histidine kinase
AUP74_RS08520	COG0837	glucose binding
AUP74_RS08525	COG1472	Belongs to the glycosyl hydrolase 3 family
AUP74_RS08530	COG1472	Belongs to the glycosyl hydrolase 3 family
AUP74_RS08550	COG1505	serine-type exopeptidase activity
AUP74_RS08570	COG2205	protein histidine kinase activity
AUP74_RS08580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AUP74_RS08595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AUP74_RS08600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AUP74_RS08605	COG3240	lipase activity
AUP74_RS08605	COG4625	pathogenesis
AUP74_RS08610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AUP74_RS08640	COG0154	amidase activity
AUP74_RS08645	COG0436	Aminotransferase
AUP74_RS08655	COG1404	Belongs to the peptidase S8 family
AUP74_RS08665	COG1091	dTDP-4-dehydrorhamnose reductase activity
AUP74_RS08670	COG1088	dTDP-glucose 4,6-dehydratase activity
AUP74_RS08705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AUP74_RS08720	COG1088	dTDP-glucose 4,6-dehydratase activity
AUP74_RS08760	COG0438	transferase activity, transferring glycosyl groups
AUP74_RS08770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AUP74_RS08790	COG4464	protein tyrosine phosphatase activity
AUP74_RS08805	COG0471	metal ion transport
AUP74_RS08805	COG3273	potassium ion transport
AUP74_RS08815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AUP74_RS08825	COG0110	maltose O-acetyltransferase activity
AUP74_RS08895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AUP74_RS08905	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AUP74_RS08910	COG1088	dTDP-glucose 4,6-dehydratase activity
AUP74_RS08930	COG0513	Belongs to the DEAD box helicase family
AUP74_RS08935	COG3038	cytochrome b561
AUP74_RS08945	COG0006	proline dipeptidase activity
AUP74_RS08950	COG0788	formyltetrahydrofolate deformylase activity
AUP74_RS08985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AUP74_RS08985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AUP74_RS09000	COG0018	arginyl-trna synthetase
AUP74_RS09005	COG2925	Exonuclease
AUP74_RS09010	COG0540	Belongs to the ATCase OTCase family
AUP74_RS09025	COG0330	HflC and HflK could
AUP74_RS09035	COG0166	Belongs to the GPI family
AUP74_RS09045	COG1757	Na H antiporter
AUP74_RS09055	COG1199	ATP-dependent helicase activity
AUP74_RS09060	COG3098	single-species biofilm formation
AUP74_RS09065	COG4067	protein conserved in archaea
AUP74_RS09065	COG0189	ligase activity
AUP74_RS09075	COG0189	ligase activity
AUP74_RS09120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AUP74_RS09140	COG0105	UTP biosynthetic process
AUP74_RS09145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AUP74_RS09160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AUP74_RS09165	COG0124	histidyl-tRNA synthetase
AUP74_RS09170	COG2976	Protein conserved in bacteria
AUP74_RS09180	COG1160	GTP binding
AUP74_RS09210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUP74_RS09215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUP74_RS09220	COG0786	glutamate:sodium symporter activity
AUP74_RS09235	COG1007	ATP synthesis coupled electron transport
AUP74_RS09245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AUP74_RS09250	COG0713	ATP synthesis coupled electron transport
AUP74_RS09260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AUP74_RS09265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AUP74_RS09285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AUP74_RS09285	COG0649	NAD binding
AUP74_RS09290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AUP74_RS09295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AUP74_RS09310	COG0525	valine-tRNA ligase activity
AUP74_RS09325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AUP74_RS09330	COG0795	lipopolysaccharide-transporting ATPase activity
AUP74_RS09335	COG0795	lipopolysaccharide-transporting ATPase activity
AUP74_RS09355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AUP74_RS09365	COG2226	methyltransferase
AUP74_RS09380	COG2814	Major facilitator Superfamily
AUP74_RS09405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AUP74_RS09410	COG0343	queuine tRNA-ribosyltransferase activity
AUP74_RS09420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AUP74_RS09440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AUP74_RS09445	COG0418	dihydroorotase activity
AUP74_RS09450	COG0137	argininosuccinate synthase activity
AUP74_RS09455	COG3278	Belongs to the heme-copper respiratory oxidase family
AUP74_RS09470	COG2010	Cytochrome c
AUP74_RS09485	COG2217	Heavy metal translocating P-type atpase
AUP74_RS09525	COG3023	N-Acetylmuramoyl-L-alanine amidase
AUP74_RS09530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AUP74_RS09535	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS09540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AUP74_RS09545	COG1881	PFAM PEBP family protein
AUP74_RS09555	COG3695	enzyme binding
AUP74_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS09570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AUP74_RS09580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AUP74_RS09585	COG0459	protein refolding
AUP74_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS09680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AUP74_RS09710	COG1840	ABC-type Fe3 transport system, periplasmic component
AUP74_RS09720	COG3842	ATPase activity
AUP74_RS09725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AUP74_RS09730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AUP74_RS09735	COG4181	ATPase activity
AUP74_RS09745	COG0037	tRNA processing
AUP74_RS09760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AUP74_RS09775	COG0686	Belongs to the AlaDH PNT family
AUP74_RS09815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AUP74_RS09820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AUP74_RS09830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AUP74_RS09835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AUP74_RS09840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AUP74_RS09845	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AUP74_RS09850	COG0589	response to stress
AUP74_RS09870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AUP74_RS09870	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AUP74_RS09880	COG2154	pterin-4-alpha-carbinolamine dehydratase
AUP74_RS09890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AUP74_RS09895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AUP74_RS09910	COG1231	oxidoreductase activity
AUP74_RS09955	COG3118	belongs to the thioredoxin family
AUP74_RS09960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AUP74_RS09960	COG3323	Protein of unknown function (DUF1653)
AUP74_RS09975	COG2235	arginine
AUP74_RS10000	COG5265	(ABC) transporter
AUP74_RS10020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AUP74_RS10040	COG0825	malonyl-CoA metabolic process
AUP74_RS10045	COG1307	EDD domain protein, DegV family
AUP74_RS10050	COG0477	Major facilitator Superfamily
AUP74_RS10060	COG0037	tRNA processing
AUP74_RS10065	COG0504	CTP synthase activity
AUP74_RS10070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AUP74_RS10075	COG0148	phosphopyruvate hydratase activity
AUP74_RS10080	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AUP74_RS10085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AUP74_RS10090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AUP74_RS10095	COG0585	pseudouridine synthase activity
AUP74_RS10100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AUP74_RS10120	COG3784	Protein of unknown function (DUF1318)
AUP74_RS10140	COG0308	aminopeptidase N
AUP74_RS10150	COG0446	pyridine nucleotide-disulphide oxidoreductase
AUP74_RS10150	COG1902	pentaerythritol trinitrate reductase activity
AUP74_RS10165	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS10180	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS10205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AUP74_RS10225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AUP74_RS10235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AUP74_RS10240	COG2137	regulation of response to DNA damage stimulus
AUP74_RS10250	COG3588	fructose-bisphosphate aldolase
AUP74_RS10260	COG2835	tetraacyldisaccharide 4'-kinase activity
AUP74_RS10265	COG0537	adenosine 5'-monophosphoramidase activity
AUP74_RS10270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AUP74_RS10275	COG0527	aspartate kinase activity
AUP74_RS10280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AUP74_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS10335	COG0783	Belongs to the Dps family
AUP74_RS10340	COG0583	DNA-binding transcription factor activity
AUP74_RS10345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AUP74_RS10370	COG3228	Belongs to the MtfA family
AUP74_RS10410	COG1796	DNA polymerase
AUP74_RS10410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AUP74_RS10415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AUP74_RS10430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AUP74_RS10435	COG0484	heat shock protein binding
AUP74_RS10440	COG0271	Belongs to the BolA IbaG family
AUP74_RS10460	COG0514	ATP-dependent DNA helicase (RecQ)
AUP74_RS10485	COG0716	FMN binding
AUP74_RS10490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AUP74_RS10500	COG0011	TIGRFAM Protein of
AUP74_RS10510	COG3089	Belongs to the UPF0270 family
AUP74_RS10535	COG3101	peptidyl-lysine hydroxylation
AUP74_RS10540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AUP74_RS10540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AUP74_RS10545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AUP74_RS10565	COG0436	Aminotransferase
AUP74_RS10570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUP74_RS10615	COG1131	(ABC) transporter
AUP74_RS10620	COG0842	Transport permease protein
AUP74_RS10625	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AUP74_RS10625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AUP74_RS10645	COG0778	Nitroreductase
AUP74_RS10665	COG2076	Multidrug Resistance protein
AUP74_RS10690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS10695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AUP74_RS10725	COG0523	cobalamin synthesis protein
AUP74_RS10745	COG2985	domain, Protein
AUP74_RS10745	COG0569	domain protein
AUP74_RS10755	COG1228	amidohydrolase
AUP74_RS10760	COG2860	membrane
AUP74_RS10765	COG0038	chloride channel
AUP74_RS10795	COG2095	MarC family integral membrane protein
AUP74_RS10810	COG1446	asparaginase
AUP74_RS10815	COG0668	transmembrane transport
AUP74_RS10880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AUP74_RS10895	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AUP74_RS10910	COG1739	Uncharacterized protein family UPF0029
AUP74_RS10965	COG3115	cell septum assembly
AUP74_RS10970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AUP74_RS11000	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS11010	COG0318	PFAM AMP-dependent synthetase and ligase
AUP74_RS11025	COG2866	Carboxypeptidase
AUP74_RS11050	COG2072	flavoprotein involved in K transport
AUP74_RS11055	COG0385	Bile acid
AUP74_RS11070	COG0071	Belongs to the small heat shock protein (HSP20) family
AUP74_RS11075	COG1279	arginine transmembrane transporter activity
AUP74_RS11080	COG0084	hydrolase, TatD family'
AUP74_RS11090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AUP74_RS11095	COG3011	Protein conserved in bacteria
AUP74_RS11100	COG1047	Peptidyl-prolyl cis-trans
AUP74_RS11120	COG3106	COG3106 Predicted ATPase
AUP74_RS11125	COG3768	UPF0283 membrane protein
AUP74_RS11170	COG4977	sequence-specific DNA binding
AUP74_RS11170	COG1917	Cupin 2, conserved barrel domain protein
AUP74_RS11185	COG1250	3-hydroxyacyl-CoA dehydrogenase
AUP74_RS11185	COG1024	Enoyl-CoA hydratase
AUP74_RS11190	COG0183	Belongs to the thiolase family
AUP74_RS11200	COG0544	peptidyl-prolyl cis-trans isomerase activity
AUP74_RS11205	COG0740	serine-type endopeptidase activity
AUP74_RS11210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AUP74_RS11215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AUP74_RS11225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AUP74_RS11230	COG0741	lytic transglycosylase activity
AUP74_RS11230	COG1388	LysM domain
AUP74_RS11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUP74_RS11240	COG2226	methyltransferase
AUP74_RS11245	COG0328	RNA-DNA hybrid ribonuclease activity
AUP74_RS11250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AUP74_RS11255	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AUP74_RS11265	COG2816	NAD+ diphosphatase activity
AUP74_RS11275	COG0616	signal peptide processing
AUP74_RS11280	COG0604	alcohol dehydrogenase
AUP74_RS11295	COG0210	DNA helicase
AUP74_RS11315	COG0640	Transcriptional regulator
AUP74_RS11330	COG0659	secondary active sulfate transmembrane transporter activity
AUP74_RS11335	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUP74_RS11335	COG0596	Alpha beta hydrolase
AUP74_RS11355	COG3634	alkyl hydroperoxide reductase activity
AUP74_RS11390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUP74_RS11395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS11405	COG0702	epimerase
AUP74_RS11420	COG1051	belongs to the nudix hydrolase family
AUP74_RS11450	COG0450	alkyl hydroperoxide reductase
AUP74_RS11470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS11475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS11565	COG0778	Nitroreductase
AUP74_RS11575	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUP74_RS11580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AUP74_RS11585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AUP74_RS11590	COG0215	cysteine-tRNA ligase activity
AUP74_RS11620	COG1956	GAF domain-containing protein
AUP74_RS11635	COG2813	Specifically methylates the guanine in position
AUP74_RS11640	COG1187	pseudouridine synthase activity
AUP74_RS11645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AUP74_RS11665	COG0529	Catalyzes the synthesis of activated sulfate
AUP74_RS11705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AUP74_RS11730	COG1388	LysM domain
AUP74_RS11730	COG1134	teichoic acid transport
AUP74_RS11745	COG0438	transferase activity, transferring glycosyl groups
AUP74_RS11755	COG2304	oxidoreductase activity
AUP74_RS11775	COG0714	Associated with various cellular activities
AUP74_RS11785	COG0167	dihydroorotate dehydrogenase activity
AUP74_RS11790	COG3130	regulation of translation
AUP74_RS11795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AUP74_RS11795	COG0116	Belongs to the methyltransferase superfamily
AUP74_RS11810	COG0631	protein serine/threonine phosphatase activity
AUP74_RS11830	COG0488	(ABC) transporter
AUP74_RS11835	COG0589	response to stress
AUP74_RS11860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AUP74_RS11880	COG1472	Belongs to the glycosyl hydrolase 3 family
AUP74_RS11885	COG0668	transmembrane transport
AUP74_RS11890	COG1278	Cold shock
AUP74_RS11905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AUP74_RS11915	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AUP74_RS11920	COG1805	sodium ion transport
AUP74_RS11935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AUP74_RS11940	COG2871	sodium ion transport
AUP74_RS11945	COG1477	protein flavinylation
AUP74_RS11955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AUP74_RS11960	COG2050	protein possibly involved in aromatic compounds catabolism
AUP74_RS11975	COG0318	PFAM AMP-dependent synthetase and ligase
AUP74_RS11985	COG0596	Alpha beta hydrolase
AUP74_RS11995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AUP74_RS12015	COG4591	ABC-type transport system involved in lipoprotein release permease component
AUP74_RS12020	COG1136	(ABC) transporter
AUP74_RS12025	COG4591	ABC-type transport system involved in lipoprotein release permease component
AUP74_RS12050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AUP74_RS12055	COG0372	Belongs to the citrate synthase family
AUP74_RS12110	COG0417	DNA replication proofreading
AUP74_RS12140	COG2197	response regulator
AUP74_RS12145	COG4585	Histidine kinase
AUP74_RS12160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AUP74_RS12165	COG0513	Belongs to the DEAD box helicase family
AUP74_RS12170	COG2079	MmgE PrpD family protein
AUP74_RS12180	COG2333	competence protein COMEC
AUP74_RS12180	COG0658	competence protein
AUP74_RS12195	COG0811	peptide transport
AUP74_RS12200	COG0848	biopolymer transport protein
AUP74_RS12205	COG1132	(ABC) transporter
AUP74_RS12210	COG1663	tetraacyldisaccharide 4'-kinase activity
AUP74_RS12215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AUP74_RS12235	COG0322	excinuclease ABC activity
AUP74_RS12265	COG1946	Acyl-CoA thioesterase
AUP74_RS12270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AUP74_RS12390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AUP74_RS12395	COG0640	Transcriptional regulator
AUP74_RS12405	COG0793	Belongs to the peptidase S41A family
AUP74_RS12425	COG2212	antiporter activity
AUP74_RS12430	COG1320	monovalent cation:proton antiporter activity
AUP74_RS12440	COG1006	Multisubunit Na H antiporter MnhC subunit
AUP74_RS12445	COG0651	ATP synthesis coupled electron transport
AUP74_RS12450	COG0651	ATP synthesis coupled electron transport
AUP74_RS12460	COG0651	ATP synthesis coupled electron transport
AUP74_RS12465	COG1309	transcriptional regulator
AUP74_RS12470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUP74_RS12475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AUP74_RS12495	COG2207	Transcriptional regulator
AUP74_RS12500	COG4221	oxidoreductase activity
AUP74_RS12515	COG1064	alcohol dehydrogenase
AUP74_RS12520	COG0037	tRNA processing
AUP74_RS12520	COG0590	tRNA wobble adenosine to inosine editing
AUP74_RS12525	COG3384	dioxygenase
AUP74_RS12530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AUP74_RS12545	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS12550	COG0604	alcohol dehydrogenase
AUP74_RS12555	COG0826	peptidase U32
AUP74_RS12575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AUP74_RS12580	COG1335	isochorismatase
AUP74_RS12585	COG2149	membrane
AUP74_RS12590	COG0309	Hydrogenase expression formation protein (HypE)
AUP74_RS12600	COG0298	carbon dioxide binding
AUP74_RS12605	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AUP74_RS12610	COG0375	protein maturation
AUP74_RS12650	COG0574	Belongs to the PEP-utilizing enzyme family
AUP74_RS12650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AUP74_RS12660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AUP74_RS12665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AUP74_RS12670	COG0022	dehydrogenase e1 component
AUP74_RS12670	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUP74_RS12680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AUP74_RS12700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AUP74_RS12705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AUP74_RS12705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AUP74_RS12715	COG0356	it plays a direct role in the translocation of protons across the membrane
AUP74_RS12730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AUP74_RS12735	COG1741	Belongs to the pirin family
AUP74_RS12740	COG0429	hydrolase of the alpha beta-hydrolase fold
AUP74_RS12755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AUP74_RS12760	COG4771	TonB-dependent receptor
AUP74_RS12775	COG1648	precorrin-2 dehydrogenase activity
AUP74_RS12775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AUP74_RS12780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AUP74_RS12785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AUP74_RS12790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AUP74_RS12795	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AUP74_RS12805	COG0492	ferredoxin-NADP+ reductase activity
AUP74_RS12810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AUP74_RS12815	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AUP74_RS12820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AUP74_RS12825	COG0542	response to heat
AUP74_RS12830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AUP74_RS12835	COG1278	Cold shock
AUP74_RS12855	COG2915	High frequency lysogenization protein hflD homolog
AUP74_RS12865	COG2850	peptidyl-arginine hydroxylation
AUP74_RS12870	COG2153	protein acetylation
AUP74_RS12900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AUP74_RS12905	COG0857	belongs to the CobB CobQ family
AUP74_RS12905	COG0280	phosphate acetyltransferase
AUP74_RS12910	COG2329	Antibiotic biosynthesis monooxygenase
AUP74_RS12915	COG0427	acetyl-CoA hydrolase
AUP74_RS12925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AUP74_RS12970	COG4774	siderophore transport
AUP74_RS12975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AUP74_RS12980	COG0174	glutamine synthetase
AUP74_RS12985	COG1115	amino acid carrier protein
AUP74_RS12990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AUP74_RS12995	COG1862	Preprotein translocase
AUP74_RS13005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AUP74_RS13015	COG0039	L-malate dehydrogenase activity
AUP74_RS13025	COG0084	hydrolase, TatD family'
AUP74_RS13040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AUP74_RS13045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AUP74_RS13055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AUP74_RS13060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AUP74_RS13070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AUP74_RS13075	COG0416	fatty acid biosynthetic process
AUP74_RS13080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AUP74_RS13085	COG1399	metal-binding, possibly nucleic acid-binding protein
AUP74_RS13095	COG0546	phosphoglycolate phosphatase activity
AUP74_RS13105	COG1530	ribonuclease E activity
AUP74_RS13115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AUP74_RS13120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AUP74_RS13125	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS13135	COG0398	Pfam SNARE associated Golgi protein
AUP74_RS13155	COG0670	Belongs to the BI1 family
AUP74_RS13165	COG2923	Belongs to the DsrF TusC family
AUP74_RS13170	COG2168	tRNA wobble position uridine thiolation
AUP74_RS13175	COG2920	part of a sulfur-relay system
AUP74_RS13180	COG0432	Pfam Uncharacterised protein family UPF0047
AUP74_RS13185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AUP74_RS13215	COG1074	ATP-dependent DNA helicase activity
AUP74_RS13220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AUP74_RS13230	COG0500	methyltransferase
AUP74_RS13240	COG1643	Atp-dependent helicase
AUP74_RS13245	COG2342	PFAM TM1410 hypothetical-related protein
AUP74_RS13255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AUP74_RS13255	COG0316	Belongs to the HesB IscA family
AUP74_RS13270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AUP74_RS13280	COG0017	Asparaginyl-tRNA synthetase
AUP74_RS13285	COG0668	transmembrane transport
AUP74_RS13305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AUP74_RS13325	COG1522	sequence-specific DNA binding
AUP74_RS13335	COG4651	solute:proton antiporter activity
AUP74_RS13335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AUP74_RS13350	COG1538	Outer membrane efflux protein
AUP74_RS13355	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS13385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUP74_RS13400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AUP74_RS13405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AUP74_RS13425	COG4106	trans-aconitate 2-methyltransferase activity
AUP74_RS13430	COG0500	methyltransferase
AUP74_RS13435	COG1760	l-serine dehydratase
AUP74_RS13440	COG0742	ribosomal rna small subunit methyltransferase
AUP74_RS13480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AUP74_RS13495	COG1309	transcriptional regulator
AUP74_RS13505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AUP74_RS13510	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS13515	COG1024	Enoyl-CoA hydratase
AUP74_RS13525	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS13530	COG1115	amino acid carrier protein
AUP74_RS13550	COG2132	Multicopper oxidase
AUP74_RS13555	COG3667	copper resistance
AUP74_RS13575	COG1136	(ABC) transporter
AUP74_RS13590	COG3509	depolymerase
AUP74_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS13610	COG3119	arylsulfatase activity
AUP74_RS13615	COG1063	alcohol dehydrogenase
AUP74_RS13625	COG3119	arylsulfatase activity
AUP74_RS13630	COG3119	arylsulfatase activity
AUP74_RS13665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AUP74_RS13675	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AUP74_RS13705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AUP74_RS13705	COG0506	proline dehydrogenase activity
AUP74_RS13705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AUP74_RS13725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AUP74_RS13735	COG0493	'glutamate synthase
AUP74_RS13740	COG4221	oxidoreductase activity
AUP74_RS13750	COG1595	DNA-templated transcription, initiation
AUP74_RS13765	COG1522	sequence-specific DNA binding
AUP74_RS13785	COG0339	signal peptide processing
AUP74_RS13790	COG0438	transferase activity, transferring glycosyl groups
AUP74_RS13805	COG0625	glutathione transferase activity
AUP74_RS13810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AUP74_RS13815	COG1448	Aminotransferase
AUP74_RS13825	COG0625	glutathione transferase activity
AUP74_RS13880	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AUP74_RS13885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AUP74_RS13900	COG4191	Histidine kinase
AUP74_RS13900	COG0784	Response regulator, receiver
AUP74_RS13925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AUP74_RS13930	COG0247	lactate metabolic process
AUP74_RS13935	COG0277	FAD linked oxidase domain protein
AUP74_RS13940	COG0277	FAD linked oxidase domain protein
AUP74_RS13950	COG3876	Protein conserved in bacteria
AUP74_RS13965	COG1757	Na H antiporter
AUP74_RS13970	COG1619	proteins homologs of microcin C7 resistance protein MccF
AUP74_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
AUP74_RS14015	COG3023	N-Acetylmuramoyl-L-alanine amidase
AUP74_RS14025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AUP74_RS14030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AUP74_RS14040	COG1984	allophanate hydrolase subunit 2
AUP74_RS14045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AUP74_RS14050	COG4336	lyase activity
AUP74_RS14055	COG0154	amidase activity
AUP74_RS14105	COG0564	pseudouridine synthase activity
AUP74_RS14130	COG0626	cystathionine gamma-synthase activity
AUP74_RS14135	COG1522	sequence-specific DNA binding
AUP74_RS14145	COG1757	Na H antiporter
AUP74_RS14160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AUP74_RS14170	COG1690	Belongs to the RtcB family
AUP74_RS14325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AUP74_RS14335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AUP74_RS14340	COG4771	TonB-dependent receptor
AUP74_RS14345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AUP74_RS14350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AUP74_RS14355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AUP74_RS14380	COG2030	dehydratase
AUP74_RS14385	COG2301	Belongs to the HpcH HpaI aldolase family
AUP74_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS14415	COG1335	isochorismatase
AUP74_RS14430	COG2188	Transcriptional regulator
AUP74_RS14445	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS14480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AUP74_RS14490	COG4771	TonB-dependent receptor
AUP74_RS14515	COG1335	isochorismatase
AUP74_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
AUP74_RS14530	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS14545	COG2814	Major facilitator Superfamily
AUP74_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS14570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AUP74_RS14580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AUP74_RS14585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AUP74_RS14595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AUP74_RS14600	COG2226	methyltransferase
AUP74_RS14610	COG1024	Enoyl-CoA hydratase
AUP74_RS14615	COG0154	amidase activity
AUP74_RS14640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AUP74_RS14680	COG1611	Belongs to the LOG family
AUP74_RS14685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AUP74_RS14705	COG0776	regulation of translation
AUP74_RS14710	COG0072	phenylalanine-tRNA ligase activity
AUP74_RS14715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AUP74_RS14720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AUP74_RS14725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AUP74_RS14730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AUP74_RS14735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AUP74_RS14770	COG1555	photosystem II stabilization
AUP74_RS14780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AUP74_RS14790	COG0776	regulation of translation
AUP74_RS14800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AUP74_RS14805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AUP74_RS14810	COG0077	Prephenate dehydratase
AUP74_RS14810	COG1605	Chorismate mutase
AUP74_RS14815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AUP74_RS14825	COG0402	S-adenosylhomocysteine deaminase activity
AUP74_RS14830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AUP74_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS14865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AUP74_RS14880	COG0438	transferase activity, transferring glycosyl groups
AUP74_RS14900	COG1522	sequence-specific DNA binding
AUP74_RS14940	COG0174	glutamine synthetase
AUP74_RS14950	COG1027	Aspartate ammonia-lyase
AUP74_RS14965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AUP74_RS14970	COG1288	antiporter activity
AUP74_RS14975	COG4206	TonB-dependent receptor
AUP74_RS14980	COG4242	Belongs to the peptidase S51 family
AUP74_RS15010	COG2968	Membrane
AUP74_RS15015	COG1228	amidohydrolase
AUP74_RS15025	COG1196	nuclear chromosome segregation
AUP74_RS15025	COG3264	Mechanosensitive ion channel
AUP74_RS15030	COG0569	domain protein
AUP74_RS15030	COG0189	ligase activity
AUP74_RS15035	COG0612	Peptidase, M16
AUP74_RS15045	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AUP74_RS15050	COG2195	Cleaves the N-terminal amino acid of tripeptides
AUP74_RS15055	COG2738	Putative neutral zinc metallopeptidase
AUP74_RS15065	COG0009	L-threonylcarbamoyladenylate synthase
AUP74_RS15070	COG3002	Belongs to the UPF0753 family
AUP74_RS15075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AUP74_RS15080	COG0583	DNA-binding transcription factor activity
AUP74_RS15140	COG2974	May be involved in recombination
AUP74_RS15155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AUP74_RS15160	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AUP74_RS15165	COG1024	Enoyl-CoA hydratase
AUP74_RS15175	COG1228	amidohydrolase
AUP74_RS15190	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AUP74_RS15195	COG3122	Protein conserved in bacteria
AUP74_RS15245	COG2153	protein acetylation
AUP74_RS15265	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AUP74_RS15295	COG2084	Dehydrogenase
AUP74_RS15305	COG1214	PFAM Peptidase M22, glycoprotease
AUP74_RS15315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AUP74_RS15320	COG0563	adenylate kinase activity
AUP74_RS15325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AUP74_RS15330	COG3956	TIGRFAM MazG family protein
AUP74_RS15335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AUP74_RS15345	COG0784	Response regulator, receiver
AUP74_RS15345	COG5002	protein histidine kinase activity
AUP74_RS15345	COG2205	protein histidine kinase activity
AUP74_RS15365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AUP74_RS15370	COG0571	ribonuclease III activity
AUP74_RS15380	COG0681	Belongs to the peptidase S26 family
AUP74_RS15385	COG0481	GTPase activity
AUP74_RS15390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AUP74_RS15395	COG2866	Carboxypeptidase
AUP74_RS15400	COG4948	Mandelate Racemase Muconate Lactonizing
AUP74_RS15405	COG3086	response to oxidative stress
AUP74_RS15435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AUP74_RS15445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AUP74_RS15450	COG1573	uracil-dna glycosylase
AUP74_RS15460	COG1666	GTP binding
AUP74_RS15465	COG4681	YaeQ
AUP74_RS15475	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AUP74_RS15485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AUP74_RS15495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AUP74_RS15500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AUP74_RS15515	COG1280	lysine exporter protein (LysE YggA)
AUP74_RS15520	COG0697	spore germination
AUP74_RS15540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AUP74_RS15550	COG0335	large ribosomal subunit rRNA binding
AUP74_RS15560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AUP74_RS15565	COG0228	four-way junction DNA binding
AUP74_RS15570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AUP74_RS15575	COG4137	Cytochrome C assembly protein
AUP74_RS15580	COG4536	flavin adenine dinucleotide binding
AUP74_RS15585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AUP74_RS15590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUP74_RS15595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUP74_RS15600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AUP74_RS15605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUP74_RS15615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AUP74_RS15625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AUP74_RS15630	COG0575	Belongs to the CDS family
AUP74_RS15635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AUP74_RS15640	COG0233	cytoplasmic translational termination
AUP74_RS15645	COG0528	UMP kinase activity
AUP74_RS15650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AUP74_RS15655	COG0052	Belongs to the universal ribosomal protein uS2 family
AUP74_RS15660	COG0024	Methionine aminopeptidase
AUP74_RS15665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AUP74_RS15670	COG0436	Aminotransferase
AUP74_RS15675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AUP74_RS15680	COG1393	Belongs to the ArsC family
AUP74_RS15685	COG2171	N-acyltransferase activity
AUP74_RS15690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AUP74_RS15705	COG0716	FMN binding
AUP74_RS15715	COG0745	RESPONSE REGULATOR receiver
AUP74_RS15720	COG2205	protein histidine kinase activity
AUP74_RS15735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AUP74_RS15745	COG0009	L-threonylcarbamoyladenylate synthase
AUP74_RS15750	COG0613	PHP domain protein
AUP74_RS15760	COG2350	Protein conserved in bacteria
AUP74_RS15770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AUP74_RS15785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AUP74_RS15790	COG2885	chlorophyll binding
AUP74_RS15800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AUP74_RS15800	COG0519	Catalyzes the synthesis of GMP from XMP
AUP74_RS15810	COG1570	exodeoxyribonuclease VII activity
AUP74_RS15815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AUP74_RS15820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AUP74_RS15835	COG0259	pyridoxamine-phosphate oxidase activity
AUP74_RS15855	COG0156	8-amino-7-oxononanoate synthase activity
AUP74_RS15880	COG0025	NhaP-type Na H and K H
AUP74_RS15905	COG1595	DNA-templated transcription, initiation
AUP74_RS15940	COG1960	acyl-CoA dehydrogenase activity
AUP74_RS15965	COG2226	methyltransferase
AUP74_RS15965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AUP74_RS15965	COG0596	Alpha beta hydrolase
AUP74_RS15970	COG1823	symporter activity
AUP74_RS15975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUP74_RS15980	COG1295	ribonuclease BN
AUP74_RS15985	COG1393	Belongs to the ArsC family
AUP74_RS16000	COG0616	signal peptide processing
AUP74_RS16010	COG3769	mannosylglycerate metabolic process
AUP74_RS16015	COG1215	transferase activity, transferring glycosyl groups
AUP74_RS16020	COG0366	Alpha amylase catalytic
AUP74_RS16040	COG0714	Associated with various cellular activities
AUP74_RS16055	COG1286	toxin biosynthetic process
AUP74_RS16065	COG0285	dihydrofolate synthase activity
AUP74_RS16070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AUP74_RS16075	COG0159	tryptophan synthase activity
AUP74_RS16085	COG0135	phosphoribosylanthranilate isomerase activity
AUP74_RS16115	COG0473	3-isopropylmalate dehydrogenase activity
AUP74_RS16120	COG0066	3-isopropylmalate dehydratase activity
AUP74_RS16125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AUP74_RS16140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AUP74_RS16150	COG0302	gtp cyclohydrolase
AUP74_RS16175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AUP74_RS16180	COG0326	Molecular chaperone. Has ATPase activity
AUP74_RS16190	COG0450	alkyl hydroperoxide reductase
AUP74_RS16195	COG2906	2 iron, 2 sulfur cluster binding
AUP74_RS16210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AUP74_RS16215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AUP74_RS16230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AUP74_RS16280	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AUP74_RS16285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AUP74_RS16290	COG1609	Transcriptional regulator
AUP74_RS16295	COG2942	2-epimerase
AUP74_RS16300	COG0494	nUDIX hydrolase
AUP74_RS16345	COG0778	Nitroreductase
AUP74_RS16355	COG0791	NLP P60 protein
AUP74_RS16400	COG0318	PFAM AMP-dependent synthetase and ligase
AUP74_RS16410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AUP74_RS16440	COG0183	Belongs to the thiolase family
AUP74_RS16445	COG1028	Short-chain dehydrogenase reductase Sdr
AUP74_RS16450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AUP74_RS16460	COG0471	metal ion transport
AUP74_RS16485	COG0656	L-ascorbic acid biosynthetic process
AUP74_RS16510	COG0288	reversible hydration of carbon dioxide
AUP74_RS16520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AUP74_RS16530	COG0398	Pfam SNARE associated Golgi protein
AUP74_RS16535	COG0346	lactoylglutathione lyase activity
AUP74_RS16545	COG0045	succinate-CoA ligase (ADP-forming) activity
AUP74_RS16550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AUP74_RS16570	COG1053	succinate dehydrogenase
AUP74_RS16575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AUP74_RS16590	COG4572	Cation transport regulator
AUP74_RS16595	COG3530	Putative quorum-sensing-regulated virulence factor
AUP74_RS16620	COG2081	HI0933 family
AUP74_RS16625	COG0717	Belongs to the dCTP deaminase family
AUP74_RS16630	COG1757	Na H antiporter
AUP74_RS16645	COG0587	DNA-directed DNA polymerase activity
AUP74_RS16650	COG4969	Belongs to the N-Me-Phe pilin family
AUP74_RS16680	COG0237	dephospho-CoA kinase activity
AUP74_RS16690	COG0494	nUDIX hydrolase
AUP74_RS16695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AUP74_RS16700	COG0653	protein targeting
AUP74_RS16705	COG0739	heme binding
AUP74_RS16710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AUP74_RS16715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AUP74_RS16725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AUP74_RS16730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AUP74_RS16735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AUP74_RS16740	COG0772	Belongs to the SEDS family
AUP74_RS16745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AUP74_RS16750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AUP74_RS16755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AUP74_RS16760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AUP74_RS16770	COG3116	cell division
AUP74_RS16775	COG0275	rRNA processing
AUP74_RS16780	COG2001	Belongs to the MraZ family
AUP74_RS16805	COG0792	nuclease activity
AUP74_RS16810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AUP74_RS16820	COG0183	Belongs to the thiolase family
AUP74_RS16825	COG1704	LemA family
AUP74_RS16830	COG0501	Belongs to the peptidase M48B family
AUP74_RS16845	COG2969	positive regulation of protein catabolic process
AUP74_RS16850	COG0625	glutathione transferase activity
AUP74_RS16855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AUP74_RS16860	COG0723	plastoquinol--plastocyanin reductase activity
AUP74_RS16865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AUP74_RS16870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AUP74_RS16875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AUP74_RS16885	COG2046	Belongs to the sulfate adenylyltransferase family
AUP74_RS16890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AUP74_RS16900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AUP74_RS16905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AUP74_RS16910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AUP74_RS16915	COG5007	Belongs to the BolA IbaG family
AUP74_RS16935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate