locus-tag	class	description
GL2_RS00055	COG2264	protein methyltransferase activity
GL2_RS00065	COG2826	transposase and inactivated derivatives, IS30 family
GL2_RS00085	COG2084	Dehydrogenase
GL2_RS00105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GL2_RS00110	COG0563	adenylate kinase activity
GL2_RS00115	COG3956	TIGRFAM MazG family protein
GL2_RS00120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GL2_RS00130	COG2205	protein histidine kinase activity
GL2_RS00130	COG5002	protein histidine kinase activity
GL2_RS00130	COG0784	Response regulator, receiver
GL2_RS00135	COG0736	holo-[acyl-carrier-protein] synthase activity
GL2_RS00140	COG1381	Involved in DNA repair and RecF pathway recombination
GL2_RS00145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GL2_RS00150	COG0571	ribonuclease III activity
GL2_RS00165	COG0481	GTPase activity
GL2_RS00170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GL2_RS00175	COG2866	Carboxypeptidase
GL2_RS00180	COG4948	Mandelate Racemase Muconate Lactonizing
GL2_RS00185	COG3086	response to oxidative stress
GL2_RS00215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GL2_RS00230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GL2_RS00235	COG1573	uracil-dna glycosylase
GL2_RS00260	COG1666	GTP binding
GL2_RS00265	COG4681	YaeQ
GL2_RS00275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GL2_RS00310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GL2_RS00320	COG0789	Transcriptional regulator
GL2_RS00330	COG1280	lysine exporter protein (LysE YggA)
GL2_RS00335	COG0697	spore germination
GL2_RS00355	COG0252	asparaginase activity
GL2_RS00365	COG1027	Aspartate ammonia-lyase
GL2_RS00370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GL2_RS00380	COG0336	Belongs to the RNA methyltransferase TrmD family
GL2_RS00385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GL2_RS00390	COG0228	four-way junction DNA binding
GL2_RS00395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GL2_RS00400	COG4137	Cytochrome C assembly protein
GL2_RS00410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GL2_RS00415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GL2_RS00420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GL2_RS00425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GL2_RS00455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GL2_RS00460	COG0575	Belongs to the CDS family
GL2_RS00465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GL2_RS00470	COG0233	cytoplasmic translational termination
GL2_RS00475	COG0528	UMP kinase activity
GL2_RS00480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GL2_RS00485	COG0052	Belongs to the universal ribosomal protein uS2 family
GL2_RS00490	COG0024	Methionine aminopeptidase
GL2_RS00495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GL2_RS00500	COG0436	Aminotransferase
GL2_RS00505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GL2_RS00510	COG1393	Belongs to the ArsC family
GL2_RS00520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GL2_RS00525	COG1506	peptidase
GL2_RS00525	COG4946	Tricorn protease homolog
GL2_RS00525	COG0823	Involved in the tonB-independent uptake of proteins
GL2_RS00540	COG0716	FMN binding
GL2_RS00550	COG0745	RESPONSE REGULATOR receiver
GL2_RS00555	COG2205	protein histidine kinase activity
GL2_RS00570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GL2_RS00580	COG0009	L-threonylcarbamoyladenylate synthase
GL2_RS00585	COG0613	PHP domain protein
GL2_RS00595	COG2350	Protein conserved in bacteria
GL2_RS00605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GL2_RS00610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GL2_RS00620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GL2_RS00625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GL2_RS00625	COG0519	Catalyzes the synthesis of GMP from XMP
GL2_RS00635	COG1570	exodeoxyribonuclease VII activity
GL2_RS00640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GL2_RS00650	COG4771	TonB-dependent receptor
GL2_RS00655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GL2_RS00735	COG0076	glutamate decarboxylase activity
GL2_RS00765	COG3842	ATPase activity
GL2_RS00790	COG1609	Transcriptional regulator
GL2_RS00795	COG0738	Major facilitator superfamily
GL2_RS00800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GL2_RS00805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GL2_RS00810	COG2971	BadF BadG BcrA BcrD
GL2_RS00850	COG0300	oxidoreductase activity
GL2_RS00860	COG2205	protein histidine kinase activity
GL2_RS00880	COG0459	protein refolding
GL2_RS00885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GL2_RS00895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GL2_RS01005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS01020	COG3695	enzyme binding
GL2_RS01025	COG2814	Major facilitator Superfamily
GL2_RS01035	COG1881	PFAM PEBP family protein
GL2_RS01040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GL2_RS01045	COG1012	belongs to the aldehyde dehydrogenase family
GL2_RS01050	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GL2_RS01095	COG2010	Cytochrome c
GL2_RS01110	COG3278	Belongs to the heme-copper respiratory oxidase family
GL2_RS01115	COG0137	argininosuccinate synthase activity
GL2_RS01120	COG0418	dihydroorotase activity
GL2_RS01135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GL2_RS01145	COG0343	queuine tRNA-ribosyltransferase activity
GL2_RS01150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GL2_RS01230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS01265	COG2267	carboxylic ester hydrolase activity
GL2_RS01270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GL2_RS01280	COG3621	Patatin-like phospholipase
GL2_RS01305	COG0583	DNA-binding transcription factor activity
GL2_RS01320	COG0590	tRNA wobble adenosine to inosine editing
GL2_RS01340	COG2814	Major facilitator Superfamily
GL2_RS01355	COG0590	tRNA wobble adenosine to inosine editing
GL2_RS01360	COG2226	methyltransferase
GL2_RS01370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GL2_RS01385	COG0795	lipopolysaccharide-transporting ATPase activity
GL2_RS01390	COG0795	lipopolysaccharide-transporting ATPase activity
GL2_RS01395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GL2_RS01410	COG0525	valine-tRNA ligase activity
GL2_RS01425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS01470	COG2801	Transposase and inactivated derivatives
GL2_RS01510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GL2_RS01540	COG1278	Cold shock
GL2_RS01545	COG4628	conserved protein (DUF2132)
GL2_RS01565	COG2801	Transposase and inactivated derivatives
GL2_RS01590	COG3238	Protein conserved in bacteria
GL2_RS01605	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GL2_RS01615	COG0525	valine-tRNA ligase activity
GL2_RS01620	COG0525	valine-tRNA ligase activity
GL2_RS01625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GL2_RS01630	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GL2_RS01635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GL2_RS01635	COG0649	NAD binding
GL2_RS01655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GL2_RS01660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GL2_RS01665	COG0839	Belongs to the complex I subunit 6 family
GL2_RS01670	COG0713	ATP synthesis coupled electron transport
GL2_RS01675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GL2_RS01685	COG1007	ATP synthesis coupled electron transport
GL2_RS01700	COG1794	racemase activity, acting on amino acids and derivatives
GL2_RS01710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL2_RS01720	COG4232	protein-disulfide reductase activity
GL2_RS01740	COG3791	Glutathione-dependent formaldehyde-activating
GL2_RS01770	COG1160	GTP binding
GL2_RS01780	COG2976	Protein conserved in bacteria
GL2_RS01785	COG0124	histidyl-tRNA synthetase
GL2_RS01790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GL2_RS01795	COG1426	Protein conserved in bacteria
GL2_RS01805	COG1858	cytochrome C peroxidase
GL2_RS01810	COG1858	cytochrome C peroxidase
GL2_RS01815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GL2_RS01820	COG0105	UTP biosynthetic process
GL2_RS01855	COG1104	cysteine desulfurase activity
GL2_RS01900	COG3098	single-species biofilm formation
GL2_RS01905	COG1199	ATP-dependent helicase activity
GL2_RS01915	COG1757	Na H antiporter
GL2_RS01925	COG0166	Belongs to the GPI family
GL2_RS01940	COG0540	Belongs to the ATCase OTCase family
GL2_RS01945	COG2925	Exonuclease
GL2_RS01950	COG0018	arginyl-trna synthetase
GL2_RS01970	COG1191	sigma factor activity
GL2_RS01975	COG1338	Plays a role in the flagellum-specific transport system
GL2_RS02000	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GL2_RS02015	COG1157	protein secretion by the type III secretion system
GL2_RS02025	COG1766	The M ring may be actively involved in energy transduction
GL2_RS02030	COG1677	Flagellar hook-basal body complex protein FliE
GL2_RS02035	COG1558	bacterial-type flagellum-dependent cell motility
GL2_RS02040	COG1815	bacterial-type flagellum-dependent cell motility
GL2_RS02045	COG1706	bacterial-type flagellum-dependent cell motility
GL2_RS02050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GL2_RS02060	COG4786	Flagellar basal body rod
GL2_RS02065	COG4786	Flagellar basal body rod
GL2_RS02070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GL2_RS02075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GL2_RS02080	COG1684	flagellar biosynthetic protein fliR
GL2_RS02085	COG1987	bacterial-type flagellum assembly
GL2_RS02115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GL2_RS02115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GL2_RS02145	COG1917	Cupin 2, conserved barrel domain protein
GL2_RS02145	COG2207	Transcriptional regulator
GL2_RS02155	COG0788	formyltetrahydrofolate deformylase activity
GL2_RS02160	COG0006	proline dipeptidase activity
GL2_RS02170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GL2_RS02180	COG3038	cytochrome b561
GL2_RS02185	COG0513	Belongs to the DEAD box helicase family
GL2_RS02210	COG0438	transferase activity, transferring glycosyl groups
GL2_RS02210	COG1216	Glycosyl transferase, family 2
GL2_RS02225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GL2_RS02230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GL2_RS02235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GL2_RS02255	COG1088	dTDP-glucose 4,6-dehydratase activity
GL2_RS02405	COG3340	Belongs to the peptidase S51 family
GL2_RS02415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GL2_RS02560	COG0740	serine-type endopeptidase activity
GL2_RS02700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GL2_RS02735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GL2_RS02740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GL2_RS02755	COG0745	RESPONSE REGULATOR receiver
GL2_RS02760	COG2853	Lipoprotein
GL2_RS02770	COG3220	belongs to the UPF0276 family
GL2_RS02780	COG1643	Atp-dependent helicase
GL2_RS02785	COG3104	oligopeptide transport
GL2_RS02795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GL2_RS02810	COG2983	Belongs to the UPF0260 family
GL2_RS02825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GL2_RS02830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GL2_RS02840	COG1595	DNA-templated transcription, initiation
GL2_RS02875	COG3104	oligopeptide transport
GL2_RS02880	COG0730	response to heat
GL2_RS02885	COG0730	response to heat
GL2_RS02900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GL2_RS02905	COG1560	Kdo2-lipid A biosynthetic process
GL2_RS02915	COG0667	Aldo Keto reductase
GL2_RS02920	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GL2_RS02935	COG3647	Membrane
GL2_RS02940	COG1522	sequence-specific DNA binding
GL2_RS02950	COG0589	response to stress
GL2_RS02955	COG0659	secondary active sulfate transmembrane transporter activity
GL2_RS02960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS02965	COG1136	(ABC) transporter
GL2_RS02970	COG0577	efflux transmembrane transporter activity
GL2_RS02970	COG1136	(ABC) transporter
GL2_RS02985	COG2204	response regulator
GL2_RS02990	COG4191	Histidine kinase
GL2_RS03005	COG4977	sequence-specific DNA binding
GL2_RS03010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS03040	COG0508	dehydrogenase complex catalyzes the overall conversion of
GL2_RS03055	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GL2_RS03055	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GL2_RS03060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GL2_RS03065	COG0628	permease
GL2_RS03080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GL2_RS03100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GL2_RS03105	COG0602	queuosine metabolic process
GL2_RS03115	COG2885	chlorophyll binding
GL2_RS03120	COG0823	Involved in the tonB-independent uptake of proteins
GL2_RS03140	COG0824	Thioesterase
GL2_RS03145	COG2255	four-way junction helicase activity
GL2_RS03150	COG0632	four-way junction helicase activity
GL2_RS03155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GL2_RS03165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GL2_RS03180	COG0442	prolyl-tRNA aminoacylation
GL2_RS03220	COG1522	sequence-specific DNA binding
GL2_RS03240	COG1238	metal cluster binding
GL2_RS03250	COG0415	Belongs to the DNA photolyase family
GL2_RS03255	COG0789	Transcriptional regulator
GL2_RS03265	COG0247	lactate metabolic process
GL2_RS03265	COG0277	FAD linked oxidase domain protein
GL2_RS03290	COG1054	Belongs to the UPF0176 family
GL2_RS03300	COG0489	protein tyrosine kinase activity
GL2_RS03305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GL2_RS03305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GL2_RS03315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GL2_RS03335	COG0625	glutathione transferase activity
GL2_RS03340	COG4657	Part of a membrane complex involved in electron transport
GL2_RS03345	COG2878	Part of a membrane complex involved in electron transport
GL2_RS03355	COG4658	electron transport chain
GL2_RS03360	COG4659	FMN binding
GL2_RS03365	COG4660	Part of a membrane complex involved in electron transport
GL2_RS03395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GL2_RS03460	COG4783	chaperone-mediated protein folding
GL2_RS03470	COG0584	glycerophosphoryl diester phosphodiesterase
GL2_RS03475	COG1024	Enoyl-CoA hydratase
GL2_RS03480	COG2235	arginine
GL2_RS03490	COG3483	tryptophan 2,3-dioxygenase activity
GL2_RS03495	COG0848	biopolymer transport protein
GL2_RS03500	COG1803	Methylglyoxal synthase
GL2_RS03525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS03530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GL2_RS03540	COG3590	peptidase
GL2_RS03550	COG2814	Major facilitator Superfamily
GL2_RS03555	COG0672	)-iron permease
GL2_RS03560	COG0386	Belongs to the glutathione peroxidase family
GL2_RS03565	COG1846	Transcriptional regulator
GL2_RS03570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GL2_RS03585	COG0534	Mate efflux family protein
GL2_RS03605	COG2205	protein histidine kinase activity
GL2_RS03610	COG0745	RESPONSE REGULATOR receiver
GL2_RS03655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GL2_RS03675	COG4935	Belongs to the peptidase S8 family
GL2_RS03675	COG2234	aminopeptidase activity
GL2_RS03705	COG1183	phosphatidylcholine synthase activity
GL2_RS03710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GL2_RS03715	COG0440	acetolactate synthase activity
GL2_RS03720	COG0028	Belongs to the TPP enzyme family
GL2_RS03745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GL2_RS03760	COG1496	oxidoreductase activity
GL2_RS03775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GL2_RS03775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GL2_RS03825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GL2_RS03830	COG1047	Peptidyl-prolyl cis-trans
GL2_RS03840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GL2_RS03845	COG0196	riboflavin kinase activity
GL2_RS03850	COG0728	peptidoglycan biosynthetic process
GL2_RS03855	COG2885	chlorophyll binding
GL2_RS03860	COG0745	RESPONSE REGULATOR receiver
GL2_RS03865	COG2205	protein histidine kinase activity
GL2_RS03865	COG2770	Histidine kinase
GL2_RS03870	COG0268	Binds directly to 16S ribosomal RNA
GL2_RS03875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GL2_RS03880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GL2_RS03885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GL2_RS03895	COG0142	geranyltranstransferase activity
GL2_RS03910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GL2_RS03925	COG0629	single-stranded DNA binding
GL2_RS03930	COG2814	Major facilitator Superfamily
GL2_RS03955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GL2_RS03960	COG1984	allophanate hydrolase subunit 2
GL2_RS03975	COG3139	Protein of unknown function (DUF1315)
GL2_RS03980	COG0203	ribosomal protein L17
GL2_RS03985	COG0202	RNA polymerase activity
GL2_RS03990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GL2_RS03995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GL2_RS04000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GL2_RS04005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GL2_RS04015	COG0200	Binds to the 23S rRNA
GL2_RS04020	COG1841	ribosomal large subunit assembly
GL2_RS04025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GL2_RS04030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GL2_RS04035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GL2_RS04040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GL2_RS04045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GL2_RS04050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GL2_RS04055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GL2_RS04060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GL2_RS04065	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GL2_RS04070	COG0255	Belongs to the universal ribosomal protein uL29 family
GL2_RS04075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GL2_RS04080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GL2_RS04085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GL2_RS04090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GL2_RS04095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GL2_RS04100	COG0089	rRNA binding
GL2_RS04105	COG0088	Forms part of the polypeptide exit tunnel
GL2_RS04110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GL2_RS04115	COG0051	transcription antitermination factor activity, RNA binding
GL2_RS04135	COG2801	Transposase and inactivated derivatives
GL2_RS04180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GL2_RS04230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GL2_RS04235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GL2_RS04240	COG0049	tRNA binding
GL2_RS04245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GL2_RS04250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GL2_RS04255	COG0085	RNA polymerase activity
GL2_RS04260	COG0222	ribosome binding
GL2_RS04265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GL2_RS04270	COG0081	regulation of translation
GL2_RS04275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GL2_RS04295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GL2_RS04325	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GL2_RS04330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GL2_RS04330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GL2_RS04335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GL2_RS04350	COG1131	(ABC) transporter
GL2_RS04395	COG0739	heme binding
GL2_RS04400	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GL2_RS04405	COG0316	Belongs to the HesB IscA family
GL2_RS04420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GL2_RS04430	COG1981	membrane
GL2_RS04440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GL2_RS04445	COG3135	benzoate transporter
GL2_RS04460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GL2_RS04465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GL2_RS04470	COG5001	Diguanylate cyclase
GL2_RS04470	COG5002	protein histidine kinase activity
GL2_RS04495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GL2_RS04500	COG0511	ligase activity, forming carbon-carbon bonds
GL2_RS04510	COG2264	protein methyltransferase activity
GL2_RS04525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GL2_RS04530	COG0138	bifunctional purine biosynthesis protein purh
GL2_RS04535	COG0151	Belongs to the GarS family
GL2_RS04540	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GL2_RS04545	COG1765	OsmC-like protein
GL2_RS04565	COG0512	Glutamine amidotransferase of anthranilate synthase
GL2_RS04575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GL2_RS04580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GL2_RS04585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GL2_RS04590	COG3178	'Phosphotransferase
GL2_RS04595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GL2_RS04600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GL2_RS04605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GL2_RS04610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GL2_RS04615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GL2_RS04620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GL2_RS04625	COG2766	serine protein kinase
GL2_RS04635	COG2719	SpoVR family
GL2_RS04645	COG0617	tRNA 3'-terminal CCA addition
GL2_RS04655	COG0745	RESPONSE REGULATOR receiver
GL2_RS04660	COG2972	Histidine kinase
GL2_RS04685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GL2_RS04690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GL2_RS04695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GL2_RS04700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GL2_RS04705	COG1610	YqeY-like protein
GL2_RS04710	COG0358	DNA primase activity
GL2_RS04715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GL2_RS04720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GL2_RS04750	COG3321	synthase
GL2_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS04750	COG0604	alcohol dehydrogenase
GL2_RS04780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GL2_RS04805	COG3264	Mechanosensitive ion channel
GL2_RS04805	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GL2_RS04820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GL2_RS04830	COG3275	phosphorelay sensor kinase activity
GL2_RS04845	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GL2_RS04845	COG0778	Nitroreductase
GL2_RS04855	COG1960	acyl-CoA dehydrogenase activity
GL2_RS04875	COG0156	8-amino-7-oxononanoate synthase activity
GL2_RS04880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GL2_RS04905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GL2_RS04920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GL2_RS04930	COG2207	Transcriptional regulator
GL2_RS04930	COG3708	Transcriptional regulator
GL2_RS04950	COG2132	Multicopper oxidase
GL2_RS04965	COG4770	biotin carboxylase activity
GL2_RS04970	COG1024	Enoyl-CoA hydratase
GL2_RS04975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GL2_RS04980	COG1960	acyl-CoA dehydrogenase activity
GL2_RS04985	COG0789	Transcriptional regulator
GL2_RS04995	COG0560	Phosphoserine phosphatase
GL2_RS04995	COG3830	Belongs to the UPF0237 family
GL2_RS05015	COG1509	lysine 2,3-aminomutase activity
GL2_RS05025	COG0235	Class ii aldolase
GL2_RS05030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GL2_RS05035	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GL2_RS05045	COG1045	serine acetyltransferase
GL2_RS05050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GL2_RS05060	COG0753	catalase activity
GL2_RS05080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GL2_RS05090	COG1683	Conserved Protein
GL2_RS05100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GL2_RS05105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GL2_RS05130	COG0010	Belongs to the arginase family
GL2_RS05140	COG3214	Protein conserved in bacteria
GL2_RS05145	COG0305	Participates in initiation and elongation during chromosome replication
GL2_RS05150	COG0359	binds to the 23S rRNA
GL2_RS05160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GL2_RS05165	COG0360	Binds together with S18 to 16S ribosomal RNA
GL2_RS05195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GL2_RS05200	COG0557	exoribonuclease II activity
GL2_RS05225	COG2815	serine threonine protein kinase
GL2_RS05225	COG0515	serine threonine protein kinase
GL2_RS05350	COG0631	protein serine/threonine phosphatase activity
GL2_RS05355	COG3209	COG3209 Rhs family protein
GL2_RS05365	COG2951	lytic endotransglycosylase activity
GL2_RS05370	COG1272	protein, Hemolysin III
GL2_RS05375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GL2_RS05380	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GL2_RS05385	COG0330	HflC and HflK could
GL2_RS05395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GL2_RS05400	COG1923	regulation of RNA biosynthetic process
GL2_RS05405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GL2_RS05410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GL2_RS05415	COG0860	N-Acetylmuramoyl-L-alanine amidase
GL2_RS05420	COG0802	atpase or kinase
GL2_RS05425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GL2_RS05425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GL2_RS05435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GL2_RS05440	COG1162	GTPase activity
GL2_RS05450	COG0688	phosphatidylethanolamine metabolic process
GL2_RS05460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GL2_RS05465	COG0493	'glutamate synthase
GL2_RS05470	COG0069	glutamate synthase activity
GL2_RS05470	COG0070	glutamate synthase
GL2_RS05470	COG0067	glutamate synthase
GL2_RS05475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GL2_RS05480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GL2_RS05520	COG2198	Histidine kinase
GL2_RS05520	COG0784	Response regulator, receiver
GL2_RS05520	COG0643	Histidine kinase
GL2_RS05520	COG2198	Histidine kinase
GL2_RS05520	COG0784	Response regulator, receiver
GL2_RS05520	COG0643	Histidine kinase
GL2_RS05525	COG0840	transmembrane signaling receptor activity
GL2_RS05555	COG1678	Uncharacterized ACR, COG1678
GL2_RS05560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GL2_RS05600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GL2_RS05605	COG0724	RNA recognition motif
GL2_RS05620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GL2_RS05640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GL2_RS05645	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GL2_RS05685	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS05700	COG0745	RESPONSE REGULATOR receiver
GL2_RS05700	COG2972	Histidine kinase
GL2_RS05705	COG0165	Argininosuccinate lyase
GL2_RS05710	COG1965	Belongs to the frataxin family
GL2_RS05725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GL2_RS05740	COG0347	Belongs to the P(II) protein family
GL2_RS05745	COG0004	ammonium transporteR
GL2_RS05750	COG0347	Belongs to the P(II) protein family
GL2_RS05760	COG2960	long-chain fatty acid transporting porin activity
GL2_RS05765	COG0606	chelatase, subunit chli
GL2_RS05800	COG1671	Belongs to the UPF0178 family
GL2_RS05810	COG0210	DNA helicase
GL2_RS05825	COG0303	'Molybdopterin
GL2_RS05830	COG2197	response regulator
GL2_RS05840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GL2_RS05855	COG0314	molybdopterin synthase activity
GL2_RS05860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GL2_RS05865	COG0315	cyclic pyranopterin monophosphate synthase activity
GL2_RS05870	COG0521	Mo-molybdopterin cofactor biosynthetic process
GL2_RS05875	COG0746	molybdenum cofactor guanylyltransferase activity
GL2_RS05895	COG2223	nitrite transmembrane transporter activity
GL2_RS05900	COG2815	serine threonine protein kinase
GL2_RS05900	COG0515	serine threonine protein kinase
GL2_RS05915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS05985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GL2_RS06015	COG0288	reversible hydration of carbon dioxide
GL2_RS06020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GL2_RS06025	COG2181	nitrate reductase activity
GL2_RS06030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GL2_RS06035	COG1140	nitrate reductase beta subunit
GL2_RS06040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GL2_RS06045	COG3850	Histidine kinase
GL2_RS06060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GL2_RS06080	COG1690	Belongs to the RtcB family
GL2_RS06085	COG4650	regulator
GL2_RS06095	COG0730	response to heat
GL2_RS06130	COG0530	calcium, potassium:sodium antiporter activity
GL2_RS06135	COG0584	glycerophosphoryl diester phosphodiesterase
GL2_RS06140	COG0789	Transcriptional regulator
GL2_RS06160	COG2268	Band 7 protein
GL2_RS06205	COG0714	Associated with various cellular activities
GL2_RS06230	COG3040	lipid binding
GL2_RS06260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GL2_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS06305	COG2986	histidine ammonia-lyase
GL2_RS06330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GL2_RS06335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GL2_RS06355	COG2234	aminopeptidase activity
GL2_RS06380	COG4574	serine-type endopeptidase inhibitor activity
GL2_RS06400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GL2_RS06435	COG1121	(ABC) transporter
GL2_RS06440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GL2_RS06475	COG0109	protoheme IX farnesyltransferase activity
GL2_RS06500	COG1845	cytochrome c oxidase, subunit III
GL2_RS06505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GL2_RS06510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GL2_RS06520	COG0534	Mate efflux family protein
GL2_RS06535	COG0339	signal peptide processing
GL2_RS06540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GL2_RS06545	COG0583	DNA-binding transcription factor activity
GL2_RS06560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GL2_RS06570	COG0408	coproporphyrinogen oxidase activity
GL2_RS06575	COG0009	L-threonylcarbamoyladenylate synthase
GL2_RS06590	COG0758	DNA mediated transformation
GL2_RS06600	COG0242	peptide deformylase activity
GL2_RS06605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GL2_RS06620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GL2_RS06630	COG1136	(ABC) transporter
GL2_RS06650	COG0752	glycyl-tRNA synthetase alpha subunit
GL2_RS06655	COG0751	glycine-tRNA ligase activity
GL2_RS06660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GL2_RS06665	COG1404	Belongs to the peptidase S8 family
GL2_RS06675	COG1404	Belongs to the peptidase S8 family
GL2_RS06680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GL2_RS06690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GL2_RS06705	COG0175	sulfate reduction
GL2_RS06720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GL2_RS06725	COG0592	DNA-directed DNA polymerase activity
GL2_RS06730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GL2_RS06735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GL2_RS06740	COG0594	ribonuclease P activity
GL2_RS06745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GL2_RS06750	COG0706	membrane insertase activity
GL2_RS06755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GL2_RS06765	COG0445	tRNA wobble uridine modification
GL2_RS06770	COG0357	Ribosomal RNA small subunit methyltransferase G
GL2_RS06775	COG1192	Involved in chromosome partitioning
GL2_RS06780	COG1475	DNA binding
GL2_RS06785	COG3312	ion transport
GL2_RS06790	COG0356	it plays a direct role in the translocation of protons across the membrane
GL2_RS06800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GL2_RS06805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GL2_RS06810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GL2_RS06815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GL2_RS06820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GL2_RS06825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GL2_RS06885	COG0402	S-adenosylhomocysteine deaminase activity
GL2_RS06890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GL2_RS06910	COG1349	DNA-binding transcription factor activity
GL2_RS06915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GL2_RS06920	COG2945	thiolester hydrolase activity
GL2_RS06920	COG0596	Alpha beta hydrolase
GL2_RS06935	COG0025	NhaP-type Na H and K H
GL2_RS06950	COG2259	Doxx family
GL2_RS06955	COG0435	Glutathione S-transferase
GL2_RS06965	COG2814	Major facilitator Superfamily
GL2_RS06970	COG1737	Transcriptional regulator
GL2_RS06975	COG0210	DNA helicase
GL2_RS06980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GL2_RS06995	COG1607	acyl-coa hydrolase
GL2_RS07005	COG1131	(ABC) transporter
GL2_RS07010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GL2_RS07025	COG0573	inorganic phosphate transmembrane transporter activity
GL2_RS07035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GL2_RS07065	COG3022	response to hydroperoxide
GL2_RS07090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GL2_RS07095	COG3161	chorismate lyase activity
GL2_RS07100	COG1301	dicarboxylic acid transport
GL2_RS07105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GL2_RS07110	COG0583	DNA-binding transcription factor activity
GL2_RS07115	COG2261	transglycosylase associated protein
GL2_RS07130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GL2_RS07135	COG1758	RNA polymerase activity
GL2_RS07140	COG0194	GDP metabolic process
GL2_RS07150	COG1309	transcriptional regulator
GL2_RS07160	COG1404	Belongs to the peptidase S8 family
GL2_RS07170	COG1561	YicC-like family, N-terminal region
GL2_RS07175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GL2_RS07180	COG0708	Exodeoxyribonuclease III
GL2_RS07185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GL2_RS07195	COG1309	transcriptional regulator
GL2_RS07200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GL2_RS07210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GL2_RS07215	COG2003	Belongs to the UPF0758 family
GL2_RS07220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GL2_RS07225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GL2_RS07230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GL2_RS07245	COG0405	Gamma-glutamyltransferase
GL2_RS07250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GL2_RS07255	COG0742	ribosomal rna small subunit methyltransferase
GL2_RS07265	COG2884	Cell division ATP-binding protein ftsE
GL2_RS07270	COG2177	Part of the ABC transporter FtsEX involved in
GL2_RS07280	COG2363	Small membrane protein
GL2_RS07285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GL2_RS07295	COG0488	(ABC) transporter
GL2_RS07325	COG1346	cytolysis
GL2_RS07335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GL2_RS07345	COG2918	glutathione biosynthetic process
GL2_RS07355	COG0281	malic enzyme
GL2_RS07360	COG0254	rRNA binding
GL2_RS07365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GL2_RS07375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GL2_RS07380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GL2_RS07405	COG2226	methyltransferase
GL2_RS07415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GL2_RS07425	COG0140	phosphoribosyl-ATP diphosphatase activity
GL2_RS07430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GL2_RS07435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GL2_RS07470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GL2_RS07480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GL2_RS07485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GL2_RS07490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GL2_RS07495	COG0564	pseudouridine synthase activity
GL2_RS07500	COG2183	response to ionizing radiation
GL2_RS07505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS07515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GL2_RS07535	COG1233	COG1233 Phytoene dehydrogenase and related
GL2_RS07545	COG0024	Methionine aminopeptidase
GL2_RS07580	COG1301	dicarboxylic acid transport
GL2_RS07595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GL2_RS07605	COG0732	type I restriction modification DNA specificity domain
GL2_RS07610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GL2_RS07615	COG1715	Restriction endonuclease
GL2_RS07635	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GL2_RS07640	COG1194	a g-specific adenine glycosylase
GL2_RS07655	COG4771	TonB-dependent receptor
GL2_RS07670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GL2_RS07675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GL2_RS07680	COG0107	imidazoleglycerol-phosphate synthase activity
GL2_RS07685	COG0793	Belongs to the peptidase S41A family
GL2_RS07690	COG4942	peptidase
GL2_RS07695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GL2_RS07710	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GL2_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS07740	COG0469	pyruvate kinase activity
GL2_RS07755	COG2986	histidine ammonia-lyase
GL2_RS07765	COG2188	Transcriptional regulator
GL2_RS07770	COG1228	amidohydrolase
GL2_RS07775	COG0010	Belongs to the arginase family
GL2_RS07790	COG1764	response to oxidative stress
GL2_RS07845	COG1490	D-aminoacyl-tRNA deacylase activity
GL2_RS07850	COG1505	serine-type exopeptidase activity
GL2_RS07855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GL2_RS07860	COG2818	Glycosylase
GL2_RS07865	COG0668	transmembrane transport
GL2_RS07890	COG3706	GGDEF domain
GL2_RS07895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GL2_RS07905	COG1217	gtp-binding protein TYPA
GL2_RS07910	COG0301	tRNA thio-modification
GL2_RS07910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GL2_RS07915	COG0174	glutamine synthetase
GL2_RS07925	COG3852	Histidine kinase
GL2_RS07930	COG2204	response regulator
GL2_RS07940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GL2_RS07965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GL2_RS07970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GL2_RS07980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GL2_RS07985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GL2_RS07990	COG1011	Hydrolase
GL2_RS08050	COG0714	Associated with various cellular activities
GL2_RS08170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL2_RS08195	COG2267	carboxylic ester hydrolase activity
GL2_RS08255	COG0126	phosphoglycerate kinase activity
GL2_RS08285	COG2962	Rard protein
GL2_RS08290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GL2_RS08295	COG0179	Fumarylacetoacetate (FAA) hydrolase
GL2_RS08300	COG1012	belongs to the aldehyde dehydrogenase family
GL2_RS08320	COG0861	Integral membrane protein TerC family
GL2_RS08335	COG2819	hydrolase of the alpha beta superfamily
GL2_RS08410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GL2_RS08435	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GL2_RS08440	COG0251	oxidation-reduction process
GL2_RS08450	COG0454	-acetyltransferase
GL2_RS08470	COG2252	PERMEase
GL2_RS08480	COG0488	(ABC) transporter
GL2_RS08490	COG3046	protein related to deoxyribodipyrimidine photolyase
GL2_RS08495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GL2_RS08500	COG1960	acyl-CoA dehydrogenase activity
GL2_RS08505	COG1024	Enoyl-CoA hydratase
GL2_RS08505	COG1250	3-hydroxyacyl-CoA dehydrogenase
GL2_RS08510	COG0183	Belongs to the thiolase family
GL2_RS08540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GL2_RS08545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GL2_RS08570	COG3079	Belongs to the UPF0149 family
GL2_RS08575	COG0006	proline dipeptidase activity
GL2_RS08580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GL2_RS08585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GL2_RS08590	COG0705	Rhomboid family
GL2_RS08595	COG1253	flavin adenine dinucleotide binding
GL2_RS08600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GL2_RS08605	COG0509	glycine decarboxylation via glycine cleavage system
GL2_RS08610	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GL2_RS08615	COG0494	nUDIX hydrolase
GL2_RS08630	COG3108	Peptidase M15
GL2_RS08635	COG2989	Protein conserved in bacteria
GL2_RS08645	COG2989	Protein conserved in bacteria
GL2_RS08655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GL2_RS08660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GL2_RS08675	COG0811	peptide transport
GL2_RS08685	COG0848	biopolymer transport protein
GL2_RS08690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GL2_RS08700	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GL2_RS08705	COG0129	dihydroxy-acid dehydratase activity
GL2_RS08720	COG0697	spore germination
GL2_RS08725	COG0306	phosphate transporter
GL2_RS08730	COG1392	Phosphate transport regulator
GL2_RS08735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GL2_RS08780	COG1519	Transferase
GL2_RS08785	COG1538	Outer membrane efflux protein
GL2_RS08790	COG2995	paraquat-inducible protein a
GL2_RS08795	COG2995	paraquat-inducible protein a
GL2_RS08800	COG3008	intermembrane lipid transfer
GL2_RS08820	COG0494	nUDIX hydrolase
GL2_RS08825	COG3151	Protein conserved in bacteria
GL2_RS08830	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GL2_RS08840	COG3150	esterase
GL2_RS08860	COG4221	oxidoreductase activity
GL2_RS08890	COG0513	Belongs to the DEAD box helicase family
GL2_RS08905	COG1473	amidohydrolase
GL2_RS08910	COG0154	amidase activity
GL2_RS08915	COG3813	Protein conserved in bacteria
GL2_RS08920	COG0837	glucose binding
GL2_RS08965	COG0366	Alpha amylase catalytic
GL2_RS08970	COG0589	response to stress
GL2_RS08980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GL2_RS08985	COG1501	Belongs to the glycosyl hydrolase 31 family
GL2_RS08995	COG1115	amino acid carrier protein
GL2_RS09065	COG2326	polyphosphate kinase activity
GL2_RS09070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GL2_RS09075	COG0366	Alpha amylase catalytic
GL2_RS09080	COG2909	trisaccharide binding
GL2_RS09090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GL2_RS09110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GL2_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS09140	COG3273	potassium ion transport
GL2_RS09140	COG0471	metal ion transport
GL2_RS09165	COG1252	NADH dehydrogenase
GL2_RS09170	COG0709	Synthesizes selenophosphate from selenide and ATP
GL2_RS09215	COG0390	transport system, permease component
GL2_RS09220	COG3842	ATPase activity
GL2_RS09225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GL2_RS09235	COG1566	PFAM secretion protein HlyD family protein
GL2_RS09245	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GL2_RS09250	COG0248	Ppx GppA phosphatase
GL2_RS09255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GL2_RS09265	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GL2_RS09270	COG2095	MarC family integral membrane protein
GL2_RS09275	COG3706	GGDEF domain
GL2_RS09305	COG1902	pentaerythritol trinitrate reductase activity
GL2_RS09355	COG2217	Heavy metal translocating P-type atpase
GL2_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS09410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GL2_RS09410	COG0426	domain, Protein
GL2_RS09420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GL2_RS09435	COG2267	carboxylic ester hydrolase activity
GL2_RS09445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GL2_RS09450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GL2_RS09450	COG0519	Catalyzes the synthesis of GMP from XMP
GL2_RS09470	COG5265	(ABC) transporter
GL2_RS09475	COG1132	(ABC) transporter
GL2_RS09485	COG0488	(ABC) transporter
GL2_RS09490	COG1024	Enoyl-CoA hydratase
GL2_RS09500	COG3047	cAMP biosynthetic process
GL2_RS09515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GL2_RS09525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GL2_RS09545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GL2_RS09550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GL2_RS09555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GL2_RS09555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GL2_RS09570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GL2_RS09575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GL2_RS09580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GL2_RS09585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GL2_RS09595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GL2_RS09600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GL2_RS09610	COG1162	GTPase activity
GL2_RS09625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GL2_RS09630	COG0142	geranyltranstransferase activity
GL2_RS09650	COG1181	Belongs to the D-alanine--D-alanine ligase family
GL2_RS09660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GL2_RS09670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GL2_RS09675	COG2873	o-acetylhomoserine
GL2_RS09700	COG3038	cytochrome b561
GL2_RS09715	COG0204	Acyl-transferase
GL2_RS09725	COG0071	Belongs to the small heat shock protein (HSP20) family
GL2_RS09735	COG2824	Alkylphosphonate utilization operon protein PhnA
GL2_RS09740	COG2207	Transcriptional regulator
GL2_RS09745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GL2_RS09765	COG1309	transcriptional regulator
GL2_RS09775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GL2_RS09780	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GL2_RS09815	COG1294	oxidase, subunit
GL2_RS09820	COG1271	oxidase subunit
GL2_RS09835	COG0385	Bile acid
GL2_RS09865	COG0583	DNA-binding transcription factor activity
GL2_RS09880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GL2_RS09885	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GL2_RS09890	COG1320	monovalent cation:proton antiporter activity
GL2_RS09895	COG2212	antiporter activity
GL2_RS09900	COG1863	multisubunit Na H antiporter MnhE subunit
GL2_RS09910	COG1006	Multisubunit Na H antiporter MnhC subunit
GL2_RS09915	COG2111	Na H antiporter
GL2_RS09920	COG2111	Na H antiporter
GL2_RS09920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GL2_RS09925	COG1741	Belongs to the pirin family
GL2_RS09930	COG0583	DNA-binding transcription factor activity
GL2_RS09935	COG0435	Glutathione S-transferase
GL2_RS09940	COG2259	Doxx family
GL2_RS09945	COG4977	sequence-specific DNA binding
GL2_RS09945	COG1917	Cupin 2, conserved barrel domain protein
GL2_RS09955	COG3047	cAMP biosynthetic process
GL2_RS09975	COG0732	type I restriction modification DNA specificity domain
GL2_RS09985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GL2_RS10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL2_RS10020	COG1902	pentaerythritol trinitrate reductase activity
GL2_RS10040	COG0156	8-amino-7-oxononanoate synthase activity
GL2_RS10045	COG0745	RESPONSE REGULATOR receiver
GL2_RS10060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS10085	COG0732	type I restriction modification DNA specificity domain
GL2_RS10135	COG0733	neurotransmitter:sodium symporter activity
GL2_RS10140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GL2_RS10145	COG0733	neurotransmitter:sodium symporter activity
GL2_RS10150	COG2867	negative regulation of translational initiation
GL2_RS10175	COG0497	DNA recombination
GL2_RS10180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GL2_RS10185	COG0443	Heat shock 70 kDa protein
GL2_RS10190	COG0484	heat shock protein binding
GL2_RS10200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GL2_RS10205	COG0189	ligase activity
GL2_RS10205	COG4067	protein conserved in archaea
GL2_RS10215	COG0505	Belongs to the CarA family
GL2_RS10270	COG2197	response regulator
GL2_RS10290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GL2_RS10295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS10300	COG1309	transcriptional regulator
GL2_RS10310	COG0842	Transport permease protein
GL2_RS10315	COG1131	(ABC) transporter
GL2_RS10320	COG2814	Major facilitator Superfamily
GL2_RS10340	COG0243	molybdopterin cofactor binding
GL2_RS10345	COG2146	nitrite reductase [NAD(P)H] activity
GL2_RS10355	COG0515	serine threonine protein kinase
GL2_RS10355	COG2815	serine threonine protein kinase
GL2_RS10360	COG2223	nitrite transmembrane transporter activity
GL2_RS10365	COG1116	anion transmembrane transporter activity
GL2_RS10365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GL2_RS10375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GL2_RS10380	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GL2_RS10400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GL2_RS10410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GL2_RS10415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GL2_RS10420	COG0149	triose-phosphate isomerase activity
GL2_RS10435	COG0582	viral genome integration into host DNA
GL2_RS10550	COG2132	Multicopper oxidase
GL2_RS10560	COG0477	Major facilitator Superfamily
GL2_RS10620	COG0779	Required for maturation of 30S ribosomal subunits
GL2_RS10625	COG0195	Participates in both transcription termination and antitermination
GL2_RS10630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GL2_RS10635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GL2_RS10640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GL2_RS10645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GL2_RS10650	COG1185	polyribonucleotide nucleotidyltransferase activity
GL2_RS10680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GL2_RS10685	COG1428	Deoxynucleoside kinase
GL2_RS10700	COG2204	response regulator
GL2_RS10705	COG3852	Histidine kinase
GL2_RS10710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GL2_RS10715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GL2_RS10720	COG1489	DNA binding
GL2_RS10735	COG0501	Belongs to the peptidase M48B family
GL2_RS10760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GL2_RS10765	COG0174	glutamine synthetase
GL2_RS10785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL2_RS10800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GL2_RS10810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GL2_RS10875	COG0205	6-phosphofructokinase activity
GL2_RS10880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GL2_RS10900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GL2_RS10910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GL2_RS10915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GL2_RS10925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GL2_RS10930	COG0768	penicillin binding
GL2_RS10935	COG0772	Belongs to the SEDS family
GL2_RS10940	COG2951	lytic endotransglycosylase activity
GL2_RS10950	COG1686	Belongs to the peptidase S11 family
GL2_RS10960	COG0321	lipoyl(octanoyl) transferase activity
GL2_RS10965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GL2_RS10970	COG1022	Amp-dependent synthetase and ligase
GL2_RS10985	COG4625	pathogenesis
GL2_RS10985	COG3240	lipase activity
GL2_RS11020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GL2_RS11025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GL2_RS11030	COG0288	reversible hydration of carbon dioxide
GL2_RS11050	COG4264	IucA IucC family
GL2_RS11090	COG1982	Orn Lys Arg decarboxylase major
GL2_RS11105	COG2188	Transcriptional regulator
GL2_RS11110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GL2_RS11135	COG1960	acyl-CoA dehydrogenase activity
GL2_RS11140	COG2197	response regulator
GL2_RS11180	COG2197	response regulator
GL2_RS11190	COG1466	dna polymerase III delta subunit
GL2_RS11220	COG1090	epimerase
GL2_RS11235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GL2_RS11240	COG1702	phosphate starvation-inducible protein PhoH
GL2_RS11245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GL2_RS11265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GL2_RS11275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GL2_RS11280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GL2_RS11285	COG1609	Transcriptional regulator
GL2_RS11295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GL2_RS11300	COG0363	glucosamine-6-phosphate deaminase activity
GL2_RS11390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GL2_RS11430	COG0697	spore germination
GL2_RS11440	COG0193	aminoacyl-tRNA hydrolase activity
GL2_RS11445	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GL2_RS11450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GL2_RS11460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GL2_RS11475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GL2_RS11480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GL2_RS11485	COG2890	protein-(glutamine-N5) methyltransferase activity
GL2_RS11495	COG3608	succinylglutamate desuccinylase aspartoacylase
GL2_RS11500	COG0534	Mate efflux family protein
GL2_RS11510	COG2259	Doxx family
GL2_RS11535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GL2_RS11540	COG0154	amidase activity
GL2_RS11545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GL2_RS11550	COG1077	Cell shape determining protein MreB Mrl
GL2_RS11555	COG1792	Involved in formation and maintenance of cell shape
GL2_RS11565	COG0424	maF-like protein
GL2_RS11580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL2_RS11590	COG2239	Acts as a magnesium transporter
GL2_RS11600	COG1660	Displays ATPase and GTPase activities
GL2_RS11610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GL2_RS11620	COG1137	ATPase activity
GL2_RS11625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GL2_RS11635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GL2_RS11655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GL2_RS11660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GL2_RS11665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GL2_RS11680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GL2_RS11685	COG2046	Belongs to the sulfate adenylyltransferase family
GL2_RS11695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GL2_RS11700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GL2_RS11705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GL2_RS11710	COG0723	plastoquinol--plastocyanin reductase activity
GL2_RS11715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GL2_RS11720	COG0625	glutathione transferase activity
GL2_RS11725	COG2969	positive regulation of protein catabolic process
GL2_RS11735	COG3706	GGDEF domain
GL2_RS11745	COG0501	Belongs to the peptidase M48B family
GL2_RS11750	COG1704	LemA family
GL2_RS11755	COG0183	Belongs to the thiolase family
GL2_RS11765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GL2_RS11770	COG0792	nuclease activity
GL2_RS11775	COG3107	peptidoglycan biosynthetic process
GL2_RS11790	COG2001	Belongs to the MraZ family
GL2_RS11795	COG0275	rRNA processing
GL2_RS11810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GL2_RS11815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GL2_RS11820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GL2_RS11825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GL2_RS11830	COG0772	Belongs to the SEDS family
GL2_RS11835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GL2_RS11840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GL2_RS11845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GL2_RS11855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GL2_RS11860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GL2_RS11865	COG0739	heme binding
GL2_RS11870	COG0653	protein targeting
GL2_RS11875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GL2_RS11880	COG0494	nUDIX hydrolase
GL2_RS11890	COG0237	dephospho-CoA kinase activity
GL2_RS11895	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GL2_RS11920	COG0587	DNA-directed DNA polymerase activity
GL2_RS11935	COG0717	Belongs to the dCTP deaminase family
GL2_RS11940	COG2081	HI0933 family
GL2_RS11955	COG3530	Putative quorum-sensing-regulated virulence factor
GL2_RS11970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GL2_RS11990	COG2009	succinate dehydrogenase
GL2_RS11995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GL2_RS12000	COG1053	succinate dehydrogenase
GL2_RS12005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GL2_RS12025	COG0045	succinate-CoA ligase (ADP-forming) activity
GL2_RS12035	COG0534	Mate efflux family protein
GL2_RS12045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GL2_RS12075	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GL2_RS12090	COG0656	L-ascorbic acid biosynthetic process
GL2_RS12110	COG0471	metal ion transport
GL2_RS12150	COG0697	spore germination
GL2_RS12155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GL2_RS12190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GL2_RS12195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GL2_RS12225	COG0745	RESPONSE REGULATOR receiver
GL2_RS12230	COG5002	protein histidine kinase activity
GL2_RS12235	COG2906	2 iron, 2 sulfur cluster binding
GL2_RS12240	COG0450	alkyl hydroperoxide reductase
GL2_RS12250	COG0326	Molecular chaperone. Has ATPase activity
GL2_RS12255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GL2_RS12280	COG0302	gtp cyclohydrolase
GL2_RS12290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GL2_RS12375	COG2801	Transposase and inactivated derivatives
GL2_RS12395	COG2272	Belongs to the type-B carboxylesterase lipase family
GL2_RS12410	COG2274	protein secretion by the type I secretion system
GL2_RS12435	COG2211	Major facilitator Superfamily
GL2_RS12440	COG0446	pyridine nucleotide-disulphide oxidoreductase
GL2_RS12440	COG1902	pentaerythritol trinitrate reductase activity
GL2_RS12455	COG1960	acyl-CoA dehydrogenase activity
GL2_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS12500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GL2_RS12525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GL2_RS12540	COG1278	Cold shock
GL2_RS12565	COG3034	peptidoglycan biosynthetic process
GL2_RS12570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS12630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GL2_RS12640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GL2_RS12645	COG3588	fructose-bisphosphate aldolase
GL2_RS12655	COG2835	tetraacyldisaccharide 4'-kinase activity
GL2_RS12660	COG0537	adenosine 5'-monophosphoramidase activity
GL2_RS12665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GL2_RS12670	COG0527	aspartate kinase activity
GL2_RS12675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS12725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GL2_RS12740	COG2022	thiamine diphosphate biosynthetic process
GL2_RS12750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GL2_RS12755	COG0783	Belongs to the Dps family
GL2_RS12765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GL2_RS12825	COG2801	Transposase and inactivated derivatives
GL2_RS12865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS12875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GL2_RS12880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GL2_RS12885	COG4181	ATPase activity
GL2_RS12895	COG0037	tRNA processing
GL2_RS12910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GL2_RS12925	COG0686	Belongs to the AlaDH PNT family
GL2_RS12965	COG2067	long-chain fatty acid transport protein
GL2_RS12975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GL2_RS12980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GL2_RS12990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GL2_RS12995	COG0589	response to stress
GL2_RS13020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GL2_RS13020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GL2_RS13045	COG2154	pterin-4-alpha-carbinolamine dehydratase
GL2_RS13055	COG0456	acetyltransferase
GL2_RS13080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GL2_RS13095	COG2315	Protein conserved in bacteria
GL2_RS13100	COG3118	belongs to the thioredoxin family
GL2_RS13105	COG3323	Protein of unknown function (DUF1653)
GL2_RS13105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GL2_RS13120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS13160	COG0583	DNA-binding transcription factor activity
GL2_RS13175	COG5265	(ABC) transporter
GL2_RS13185	COG0625	glutathione transferase activity
GL2_RS13195	COG1742	UPF0060 membrane protein
GL2_RS13225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GL2_RS13245	COG0825	malonyl-CoA metabolic process
GL2_RS13290	COG3279	Response regulator of the LytR AlgR family
GL2_RS13295	COG3275	phosphorelay sensor kinase activity
GL2_RS13305	COG1472	Belongs to the glycosyl hydrolase 3 family
GL2_RS13310	COG2801	Transposase and inactivated derivatives
GL2_RS13330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GL2_RS13340	COG1472	Belongs to the glycosyl hydrolase 3 family
GL2_RS13350	COG0037	tRNA processing
GL2_RS13365	COG0148	phosphopyruvate hydratase activity
GL2_RS13370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GL2_RS13380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GL2_RS13385	COG0585	pseudouridine synthase activity
GL2_RS13390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GL2_RS13410	COG3784	Protein of unknown function (DUF1318)
GL2_RS13425	COG0308	aminopeptidase N
GL2_RS13475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GL2_RS13480	COG0066	3-isopropylmalate dehydratase activity
GL2_RS13485	COG0473	3-isopropylmalate dehydrogenase activity
GL2_RS13510	COG0135	phosphoribosylanthranilate isomerase activity
GL2_RS13520	COG0159	tryptophan synthase activity
GL2_RS13525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GL2_RS13530	COG0285	dihydrofolate synthase activity
GL2_RS13540	COG1286	toxin biosynthetic process
GL2_RS13555	COG0714	Associated with various cellular activities
GL2_RS13580	COG0616	signal peptide processing
GL2_RS13595	COG1393	Belongs to the ArsC family
GL2_RS13605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GL2_RS13610	COG1823	symporter activity
GL2_RS13660	COG1960	acyl-CoA dehydrogenase activity
GL2_RS13700	COG0500	methyltransferase
GL2_RS13720	COG0025	NhaP-type Na H and K H
GL2_RS13725	COG1063	alcohol dehydrogenase
GL2_RS13755	COG0443	Heat shock 70 kDa protein
GL2_RS13800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GL2_RS13825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GL2_RS13835	COG0511	ligase activity, forming carbon-carbon bonds
GL2_RS13835	COG5016	pyruvate
GL2_RS13840	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GL2_RS13850	COG0519	Catalyzes the synthesis of GMP from XMP
GL2_RS13850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GL2_RS13870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GL2_RS13875	COG0271	Belongs to the BolA IbaG family
GL2_RS13915	COG0716	FMN binding
GL2_RS13920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GL2_RS13930	COG0011	TIGRFAM Protein of
GL2_RS13955	COG0425	Belongs to the sulfur carrier protein TusA family
GL2_RS13965	COG3101	peptidyl-lysine hydroxylation
GL2_RS13975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GL2_RS13995	COG0436	Aminotransferase
GL2_RS14000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL2_RS14040	COG1131	(ABC) transporter
GL2_RS14045	COG0842	Transport permease protein
GL2_RS14050	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GL2_RS14050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GL2_RS14070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GL2_RS14075	COG1845	cytochrome c oxidase, subunit III
GL2_RS14080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GL2_RS14110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GL2_RS14140	COG4133	protoheme IX ABC transporter activity
GL2_RS14160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GL2_RS14175	COG1739	Uncharacterized protein family UPF0029
GL2_RS14180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GL2_RS14185	COG2301	Belongs to the HpcH HpaI aldolase family
GL2_RS14200	COG2977	Belongs to the P-Pant transferase superfamily
GL2_RS14210	COG3708	Transcriptional regulator
GL2_RS14210	COG2207	Transcriptional regulator
GL2_RS14220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GL2_RS14225	COG4774	siderophore transport
GL2_RS14260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GL2_RS14305	COG3115	cell septum assembly
GL2_RS14310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GL2_RS14340	COG1960	acyl-CoA dehydrogenase activity
GL2_RS14350	COG0318	PFAM AMP-dependent synthetase and ligase
GL2_RS14365	COG0427	acetyl-CoA hydrolase
GL2_RS14380	COG2866	Carboxypeptidase
GL2_RS14390	COG0084	hydrolase, TatD family'
GL2_RS14405	COG3279	Response regulator of the LytR AlgR family
GL2_RS14410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GL2_RS14415	COG3011	Protein conserved in bacteria
GL2_RS14420	COG1047	Peptidyl-prolyl cis-trans
GL2_RS14440	COG3106	COG3106 Predicted ATPase
GL2_RS14445	COG3768	UPF0283 membrane protein
GL2_RS14475	COG0071	Belongs to the small heat shock protein (HSP20) family
GL2_RS14485	COG4977	sequence-specific DNA binding
GL2_RS14485	COG1917	Cupin 2, conserved barrel domain protein
GL2_RS14500	COG1250	3-hydroxyacyl-CoA dehydrogenase
GL2_RS14500	COG1024	Enoyl-CoA hydratase
GL2_RS14505	COG0183	Belongs to the thiolase family
GL2_RS14515	COG0544	peptidyl-prolyl cis-trans isomerase activity
GL2_RS14520	COG0740	serine-type endopeptidase activity
GL2_RS14525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GL2_RS14540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GL2_RS14545	COG1388	LysM domain
GL2_RS14545	COG0741	lytic transglycosylase activity
GL2_RS14550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GL2_RS14560	COG0328	RNA-DNA hybrid ribonuclease activity
GL2_RS14570	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GL2_RS14580	COG2816	NAD+ diphosphatase activity
GL2_RS14590	COG0616	signal peptide processing
GL2_RS14595	COG0604	alcohol dehydrogenase
GL2_RS14605	COG0564	pseudouridine synthase activity
GL2_RS14620	COG3012	SEC-C Motif Domain Protein
GL2_RS14685	COG0745	RESPONSE REGULATOR receiver
GL2_RS14730	COG3012	SEC-C Motif Domain Protein
GL2_RS14770	COG1842	Phage shock protein A
GL2_RS14790	COG5463	Belongs to the UPF0441 family
GL2_RS14795	COG0754	glutathionylspermidine amidase activity
GL2_RS14800	COG0784	Response regulator, receiver
GL2_RS14800	COG4191	Histidine kinase
GL2_RS14815	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GL2_RS14860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GL2_RS14935	COG0625	glutathione transferase activity
GL2_RS14940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GL2_RS14950	COG1448	Aminotransferase
GL2_RS14955	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GL2_RS15070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS15090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GL2_RS15105	COG1250	3-hydroxyacyl-CoA dehydrogenase
GL2_RS15105	COG1024	Enoyl-CoA hydratase
GL2_RS15115	COG0318	PFAM AMP-dependent synthetase and ligase
GL2_RS15120	COG1960	acyl-CoA dehydrogenase activity
GL2_RS15125	COG1960	acyl-CoA dehydrogenase activity
GL2_RS15155	COG0625	glutathione transferase activity
GL2_RS15165	COG0339	signal peptide processing
GL2_RS15170	COG0456	acetyltransferase
GL2_RS15180	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GL2_RS15185	COG2133	pyrroloquinoline quinone binding
GL2_RS15205	COG0583	DNA-binding transcription factor activity
GL2_RS15225	COG1429	ligase activity, forming nitrogen-metal bonds
GL2_RS15285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GL2_RS15300	COG1609	Transcriptional regulator
GL2_RS15395	COG1522	sequence-specific DNA binding
GL2_RS15410	COG1595	DNA-templated transcription, initiation
GL2_RS15420	COG4221	oxidoreductase activity
GL2_RS15440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GL2_RS15455	COG0583	DNA-binding transcription factor activity
GL2_RS15470	COG1064	alcohol dehydrogenase
GL2_RS15480	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GL2_RS15480	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GL2_RS15480	COG0506	proline dehydrogenase activity
GL2_RS15495	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GL2_RS15520	COG0318	PFAM AMP-dependent synthetase and ligase
GL2_RS15550	COG1960	acyl-CoA dehydrogenase activity
GL2_RS15555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GL2_RS15580	COG1136	(ABC) transporter
GL2_RS15580	COG0577	efflux transmembrane transporter activity
GL2_RS15655	COG1752	Esterase of the alpha-beta hydrolase superfamily
GL2_RS15665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GL2_RS15675	COG3318	Belongs to the UPF0149 family
GL2_RS15675	COG3012	SEC-C Motif Domain Protein
GL2_RS15735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS15750	COG3246	L-lysine catabolic process to acetate
GL2_RS15755	COG1115	amino acid carrier protein
GL2_RS15760	COG0318	PFAM AMP-dependent synthetase and ligase
GL2_RS15790	COG0604	alcohol dehydrogenase
GL2_RS15790	COG3321	synthase
GL2_RS15795	COG3224	Antibiotic biosynthesis monooxygenase
GL2_RS15860	COG0500	methyltransferase
GL2_RS15915	COG1960	acyl-CoA dehydrogenase activity
GL2_RS15925	COG1024	Enoyl-CoA hydratase
GL2_RS15930	COG1960	acyl-CoA dehydrogenase activity
GL2_RS15935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GL2_RS15940	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS15945	COG1309	transcriptional regulator
GL2_RS15955	COG0023	Translation Initiation Factor
GL2_RS15960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GL2_RS15975	COG2900	Belongs to the SlyX family
GL2_RS16015	COG0742	ribosomal rna small subunit methyltransferase
GL2_RS16025	COG0076	glutamate decarboxylase activity
GL2_RS16030	COG4326	sporulation control protein
GL2_RS16050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GL2_RS16070	COG0316	Belongs to the HesB IscA family
GL2_RS16070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GL2_RS16100	COG2342	PFAM TM1410 hypothetical-related protein
GL2_RS16105	COG1643	Atp-dependent helicase
GL2_RS16120	COG0367	asparagine synthase
GL2_RS16135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GL2_RS16150	COG0583	DNA-binding transcription factor activity
GL2_RS16175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GL2_RS16195	COG1454	alcohol dehydrogenase
GL2_RS16200	COG0824	Thioesterase
GL2_RS16245	COG4585	Histidine kinase
GL2_RS16250	COG2197	response regulator
GL2_RS16320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS16400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS16425	COG1074	ATP-dependent DNA helicase activity
GL2_RS16440	COG1322	Protein conserved in bacteria
GL2_RS16480	COG0583	DNA-binding transcription factor activity
GL2_RS16485	COG0251	oxidation-reduction process
GL2_RS16500	COG1959	2 iron, 2 sulfur cluster binding
GL2_RS16510	COG1760	l-serine dehydratase
GL2_RS16515	COG0500	methyltransferase
GL2_RS16520	COG4106	trans-aconitate 2-methyltransferase activity
GL2_RS16540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GL2_RS16550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GL2_RS16570	COG1960	acyl-CoA dehydrogenase activity
GL2_RS16590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GL2_RS16590	COG4651	solute:proton antiporter activity
GL2_RS16595	COG1522	sequence-specific DNA binding
GL2_RS16615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GL2_RS16625	COG3033	Beta-eliminating lyase
GL2_RS16645	COG0739	heme binding
GL2_RS16660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GL2_RS16665	COG0017	Asparaginyl-tRNA synthetase
GL2_RS16695	COG1136	(ABC) transporter
GL2_RS16700	COG4591	ABC-type transport system involved in lipoprotein release permease component
GL2_RS16715	COG1802	Transcriptional regulator
GL2_RS16720	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GL2_RS16725	COG0372	Belongs to the citrate synthase family
GL2_RS16765	COG0778	Nitroreductase
GL2_RS16780	COG4953	penicillin-binding protein 1C
GL2_RS16785	COG2373	Large extracellular alpha-helical protein
GL2_RS16790	COG2957	Belongs to the agmatine deiminase family
GL2_RS16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GL2_RS16800	COG0393	Putative heavy-metal-binding
GL2_RS16835	COG1136	(ABC) transporter
GL2_RS16845	COG0826	peptidase U32
GL2_RS16860	COG2079	MmgE PrpD family protein
GL2_RS16875	COG0811	peptide transport
GL2_RS16880	COG0848	biopolymer transport protein
GL2_RS16885	COG1132	(ABC) transporter
GL2_RS16890	COG1663	tetraacyldisaccharide 4'-kinase activity
GL2_RS16895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GL2_RS16900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GL2_RS16910	COG0322	excinuclease ABC activity
GL2_RS16920	COG3119	arylsulfatase activity
GL2_RS16955	COG0783	Belongs to the Dps family
GL2_RS16980	COG0720	synthase
GL2_RS16985	COG0302	gtp cyclohydrolase
GL2_RS17015	COG1946	Acyl-CoA thioesterase
GL2_RS17095	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GL2_RS17115	COG0784	Response regulator, receiver
GL2_RS17115	COG2205	protein histidine kinase activity
GL2_RS17130	COG4989	oxidoreductase activity
GL2_RS17135	COG0693	protein deglycase activity
GL2_RS17185	COG3279	Response regulator of the LytR AlgR family
GL2_RS17190	COG3275	phosphorelay sensor kinase activity
GL2_RS17195	COG1073	alpha beta
GL2_RS17205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GL2_RS17210	COG0640	Transcriptional regulator
GL2_RS17220	COG0708	Exodeoxyribonuclease III
GL2_RS17225	COG0793	Belongs to the peptidase S41A family
GL2_RS17230	COG3040	lipid binding
GL2_RS17240	COG0673	inositol 2-dehydrogenase activity
GL2_RS17255	COG1609	Transcriptional regulator
GL2_RS17265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GL2_RS17290	COG1446	asparaginase
GL2_RS17305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GL2_RS17310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GL2_RS17315	COG0583	DNA-binding transcription factor activity
GL2_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS17325	COG0583	DNA-binding transcription factor activity
GL2_RS17345	COG4977	sequence-specific DNA binding
GL2_RS17345	COG1917	Cupin 2, conserved barrel domain protein
GL2_RS17355	COG1764	response to oxidative stress
GL2_RS17365	COG0753	catalase activity
GL2_RS17385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GL2_RS17390	COG0189	ligase activity
GL2_RS17390	COG1181	Belongs to the D-alanine--D-alanine ligase family
GL2_RS17390	COG2918	glutathione biosynthetic process
GL2_RS17395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GL2_RS17420	COG1012	belongs to the aldehyde dehydrogenase family
GL2_RS17425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GL2_RS17435	COG0527	aspartate kinase activity
GL2_RS17445	COG1917	Cupin 2, conserved barrel domain protein
GL2_RS17455	COG1846	Transcriptional regulator
GL2_RS17465	COG0436	Aminotransferase
GL2_RS17470	COG0154	amidase activity
GL2_RS17475	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GL2_RS17490	COG2072	flavoprotein involved in K transport
GL2_RS17495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GL2_RS17500	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS17505	COG1278	Cold shock
GL2_RS17510	COG0583	DNA-binding transcription factor activity
GL2_RS17615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GL2_RS17620	COG0298	carbon dioxide binding
GL2_RS17625	COG0409	Hydrogenase expression formation protein
GL2_RS17635	COG1280	lysine exporter protein (LysE YggA)
GL2_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS17715	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GL2_RS17730	COG0640	Transcriptional regulator
GL2_RS17755	COG0798	PFAM Bile acid sodium symporter
GL2_RS17765	COG2132	Multicopper oxidase
GL2_RS17770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GL2_RS17780	COG0583	DNA-binding transcription factor activity
GL2_RS17810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GL2_RS17830	COG1012	belongs to the aldehyde dehydrogenase family
GL2_RS17840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS18010	COG2986	histidine ammonia-lyase
GL2_RS18030	COG4221	oxidoreductase activity
GL2_RS18045	COG1408	metallophosphoesterase
GL2_RS18050	COG4638	Rieske (2fe-2S)
GL2_RS18055	COG1309	transcriptional regulator
GL2_RS18075	COG0584	glycerophosphoryl diester phosphodiesterase
GL2_RS18100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GL2_RS18100	COG1017	nitric oxide dioxygenase activity
GL2_RS18120	COG0513	Belongs to the DEAD box helicase family
GL2_RS18150	COG2258	MOSC domain
GL2_RS18165	COG0523	cobalamin synthesis protein
GL2_RS18195	COG2801	Transposase and inactivated derivatives
GL2_RS18205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GL2_RS18220	COG2814	Major facilitator Superfamily
GL2_RS18230	COG0367	asparagine synthase
GL2_RS18240	COG3039	Transposase
GL2_RS18255	COG1024	Enoyl-CoA hydratase
GL2_RS18320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GL2_RS18325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GL2_RS18340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GL2_RS18350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GL2_RS18355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GL2_RS18360	COG1492	cobalamin metabolic process
GL2_RS18365	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GL2_RS18380	COG5507	3-demethylubiquinone-9 3-methyltransferase
GL2_RS18425	COG1595	DNA-templated transcription, initiation
GL2_RS18430	COG2226	methyltransferase
GL2_RS18435	COG0429	hydrolase of the alpha beta-hydrolase fold
GL2_RS18445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GL2_RS18455	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GL2_RS18460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GL2_RS18480	COG1648	precorrin-2 dehydrogenase activity
GL2_RS18480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GL2_RS18485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GL2_RS18490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GL2_RS18495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GL2_RS18500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GL2_RS18520	COG0492	ferredoxin-NADP+ reductase activity
GL2_RS18525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GL2_RS18530	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GL2_RS18535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GL2_RS18540	COG0542	response to heat
GL2_RS18545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GL2_RS18550	COG1278	Cold shock
GL2_RS18560	COG1187	pseudouridine synthase activity
GL2_RS18570	COG2915	High frequency lysogenization protein hflD homolog
GL2_RS18580	COG2850	peptidyl-arginine hydroxylation
GL2_RS18590	COG3548	integral membrane protein
GL2_RS18600	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GL2_RS18620	COG3279	Response regulator of the LytR AlgR family
GL2_RS18675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GL2_RS18680	COG0857	belongs to the CobB CobQ family
GL2_RS18680	COG0280	phosphate acetyltransferase
GL2_RS18685	COG0427	acetyl-CoA hydrolase
GL2_RS18690	COG1960	acyl-CoA dehydrogenase activity
GL2_RS18700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GL2_RS18715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GL2_RS18720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GL2_RS18745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GL2_RS18750	COG0174	glutamine synthetase
GL2_RS18760	COG1115	amino acid carrier protein
GL2_RS18765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GL2_RS18770	COG1862	Preprotein translocase
GL2_RS18780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GL2_RS18790	COG0039	L-malate dehydrogenase activity
GL2_RS18800	COG0084	hydrolase, TatD family'
GL2_RS18820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GL2_RS18830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GL2_RS18835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GL2_RS18850	COG0416	fatty acid biosynthetic process
GL2_RS18855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GL2_RS18860	COG1399	metal-binding, possibly nucleic acid-binding protein
GL2_RS18870	COG0546	phosphoglycolate phosphatase activity
GL2_RS18880	COG1530	ribonuclease E activity
GL2_RS18890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GL2_RS18995	COG1783	phage Terminase large subunit
GL2_RS19040	COG2801	Transposase and inactivated derivatives
GL2_RS19110	COG0398	Pfam SNARE associated Golgi protein
GL2_RS19120	COG0438	transferase activity, transferring glycosyl groups
GL2_RS19130	COG0670	Belongs to the BI1 family
GL2_RS19135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GL2_RS19150	COG2920	part of a sulfur-relay system
GL2_RS19155	COG0432	Pfam Uncharacterised protein family UPF0047
GL2_RS19160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GL2_RS19225	COG2050	protein possibly involved in aromatic compounds catabolism
GL2_RS19240	COG1477	protein flavinylation
GL2_RS19245	COG2871	sodium ion transport
GL2_RS19250	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GL2_RS19265	COG1805	sodium ion transport
GL2_RS19270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GL2_RS19280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GL2_RS19290	COG1278	Cold shock
GL2_RS19295	COG0668	transmembrane transport
GL2_RS19300	COG1472	Belongs to the glycosyl hydrolase 3 family
GL2_RS19310	COG0318	PFAM AMP-dependent synthetase and ligase
GL2_RS19315	COG1611	Belongs to the LOG family
GL2_RS19320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GL2_RS19345	COG0589	response to stress
GL2_RS19350	COG0488	(ABC) transporter
GL2_RS19355	COG0741	lytic transglycosylase activity
GL2_RS19370	COG0631	protein serine/threonine phosphatase activity
GL2_RS19375	COG2815	serine threonine protein kinase
GL2_RS19375	COG0515	serine threonine protein kinase
GL2_RS19380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GL2_RS19380	COG0116	Belongs to the methyltransferase superfamily
GL2_RS19385	COG3130	regulation of translation
GL2_RS19390	COG0167	dihydroorotate dehydrogenase activity
GL2_RS19400	COG0714	Associated with various cellular activities
GL2_RS19420	COG2304	oxidoreductase activity
GL2_RS19455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GL2_RS19460	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GL2_RS19485	COG2089	acid synthase
GL2_RS19490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GL2_RS19500	COG1083	cytidylyl-transferase
GL2_RS19505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GL2_RS19510	COG1086	Polysaccharide biosynthesis protein
GL2_RS19525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GL2_RS19550	COG0529	Catalyzes the synthesis of activated sulfate
GL2_RS19555	COG3152	Membrane
GL2_RS19560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GL2_RS19565	COG0589	response to stress
GL2_RS19580	COG0584	glycerophosphoryl diester phosphodiesterase
GL2_RS19585	COG2801	Transposase and inactivated derivatives
GL2_RS19685	COG0740	serine-type endopeptidase activity
GL2_RS19845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GL2_RS19850	COG1187	pseudouridine synthase activity
GL2_RS19855	COG2813	Specifically methylates the guanine in position
GL2_RS19870	COG1956	GAF domain-containing protein
GL2_RS19905	COG0215	cysteine-tRNA ligase activity
GL2_RS19910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GL2_RS19915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GL2_RS19920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GL2_RS19945	COG0070	glutamate synthase
GL2_RS19945	COG0067	glutamate synthase
GL2_RS19945	COG0069	glutamate synthase activity
GL2_RS19950	COG0028	Belongs to the TPP enzyme family
GL2_RS19955	COG1982	Orn Lys Arg decarboxylase major
GL2_RS19960	COG0531	amino acid
GL2_RS19975	COG4771	TonB-dependent receptor
GL2_RS20075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GL2_RS20095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GL2_RS20105	COG3291	Pkd domain containing protein
GL2_RS20105	COG4447	cellulose binding
GL2_RS20105	COG5520	Belongs to the glycosyl hydrolase 30 family
GL2_RS20110	COG3469	chitinase activity
GL2_RS20120	COG0477	Major facilitator Superfamily
GL2_RS20135	COG1280	lysine exporter protein (LysE YggA)
GL2_RS20165	COG0811	peptide transport
GL2_RS20195	COG0604	alcohol dehydrogenase
GL2_RS20200	COG0583	DNA-binding transcription factor activity
GL2_RS20230	COG0702	epimerase
GL2_RS20295	COG3634	alkyl hydroperoxide reductase activity
GL2_RS20335	COG4771	TonB-dependent receptor
GL2_RS20350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS20405	COG0640	Transcriptional regulator
GL2_RS20425	COG0210	DNA helicase
GL2_RS20440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GL2_RS20520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GL2_RS20545	COG3621	Patatin-like phospholipase
GL2_RS20560	COG2076	Multidrug Resistance protein
GL2_RS20570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GL2_RS20645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS20655	COG3591	Belongs to the peptidase S1B family
GL2_RS20665	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GL2_RS20710	COG2801	Transposase and inactivated derivatives
GL2_RS20720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GL2_RS20740	COG0776	regulation of translation
GL2_RS20745	COG0072	phenylalanine-tRNA ligase activity
GL2_RS20750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GL2_RS20755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GL2_RS20760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GL2_RS20765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GL2_RS20770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GL2_RS20780	COG0556	nucleotide-excision repair
GL2_RS20940	COG4695	Portal protein
GL2_RS21025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GL2_RS21035	COG0284	orotidine-5'-phosphate decarboxylase activity
GL2_RS21040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GL2_RS21050	COG0776	regulation of translation
GL2_RS21060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GL2_RS21065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GL2_RS21070	COG0077	Prephenate dehydratase
GL2_RS21070	COG1605	Chorismate mutase
GL2_RS21075	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GL2_RS21085	COG0402	S-adenosylhomocysteine deaminase activity
GL2_RS21100	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS21115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GL2_RS21145	COG1522	sequence-specific DNA binding
GL2_RS21180	COG0174	glutamine synthetase
GL2_RS21215	COG2968	Membrane
GL2_RS21220	COG1228	amidohydrolase
GL2_RS21230	COG0612	Peptidase, M16
GL2_RS21245	COG2195	Cleaves the N-terminal amino acid of tripeptides
GL2_RS21275	COG0346	lactoylglutathione lyase activity
GL2_RS21295	COG1028	Short-chain dehydrogenase reductase Sdr
GL2_RS21305	COG2974	May be involved in recombination
GL2_RS21310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GL2_RS21320	COG1595	DNA-templated transcription, initiation
GL2_RS21325	COG2267	carboxylic ester hydrolase activity
GL2_RS21335	COG3122	Protein conserved in bacteria
GL2_RS21345	COG1628	Protein of unknown function DUF99