locus-tag	class	description
C2E15_RS00015	COG3312	ion transport
C2E15_RS00020	COG0356	it plays a direct role in the translocation of protons across the membrane
C2E15_RS00030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2E15_RS00050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2E15_RS00060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2E15_RS00075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2E15_RS00080	COG0573	inorganic phosphate transmembrane transporter activity
C2E15_RS00085	COG0581	inorganic phosphate transmembrane transporter activity
C2E15_RS00090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2E15_RS00095	COG0704	Plays a role in the regulation of phosphate uptake
C2E15_RS00100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E15_RS00105	COG2252	PERMEase
C2E15_RS00120	COG2197	response regulator
C2E15_RS00175	COG0706	membrane insertase activity
C2E15_RS00200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2E15_RS00205	COG0592	DNA-directed DNA polymerase activity
C2E15_RS00210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2E15_RS00220	COG0561	phosphatase activity
C2E15_RS00225	COG2186	Transcriptional regulator
C2E15_RS00230	COG3734	2-keto-3-deoxy-galactonokinase
C2E15_RS00235	COG0800	Aldolase
C2E15_RS00245	COG2271	Major facilitator Superfamily
C2E15_RS00255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E15_RS00260	COG0823	Involved in the tonB-independent uptake of proteins
C2E15_RS00265	COG5645	(Lipo)protein
C2E15_RS00280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2E15_RS00285	COG3977	Valine--pyruvate aminotransferase
C2E15_RS00300	COG2271	Major facilitator Superfamily
C2E15_RS00305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E15_RS00315	COG1609	Transcriptional regulator
C2E15_RS00320	COG2885	chlorophyll binding
C2E15_RS00325	COG2818	Glycosylase
C2E15_RS00340	COG1484	DNA-dependent DNA replication
C2E15_RS00350	COG3781	membrane
C2E15_RS00355	COG0840	transmembrane signaling receptor activity
C2E15_RS00365	COG2186	Transcriptional regulator
C2E15_RS00390	COG1815	bacterial-type flagellum-dependent cell motility
C2E15_RS00395	COG1558	bacterial-type flagellum-dependent cell motility
C2E15_RS00400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2E15_RS00410	COG4787	bacterial-type flagellum-dependent cell motility
C2E15_RS00440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2E15_RS00445	COG0840	transmembrane signaling receptor activity
C2E15_RS00475	COG0643	Histidine kinase
C2E15_RS00475	COG2198	Histidine kinase
C2E15_RS00480	COG0835	chemotaxis
C2E15_RS00515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2E15_RS00520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2E15_RS00525	COG0745	RESPONSE REGULATOR receiver
C2E15_RS00530	COG2201	protein-glutamate methylesterase activity
C2E15_RS00535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2E15_RS00545	COG1766	The M ring may be actively involved in energy transduction
C2E15_RS00550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2E15_RS00555	COG1317	bacterial-type flagellum organization
C2E15_RS00570	COG3144	bacterial-type flagellum assembly
C2E15_RS00585	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2E15_RS00590	COG3190	flagellar
C2E15_RS00610	COG2223	nitrite transmembrane transporter activity
C2E15_RS00620	COG1609	Transcriptional regulator
C2E15_RS00630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS00630	COG1263	PTS System
C2E15_RS00635	COG2271	Major facilitator Superfamily
C2E15_RS00640	COG4948	Mandelate Racemase Muconate Lactonizing
C2E15_RS00655	COG1609	Transcriptional regulator
C2E15_RS00655	COG2207	Transcriptional regulator
C2E15_RS00660	COG4214	carbohydrate transport
C2E15_RS00670	COG4213	ABC transporter substrate-binding protein
C2E15_RS00675	COG2115	Belongs to the xylose isomerase family
C2E15_RS00680	COG1070	Carbohydrate kinase
C2E15_RS00685	COG3274	enterobacterial common antigen metabolic process
C2E15_RS00695	COG0751	glycine-tRNA ligase activity
C2E15_RS00700	COG3276	selenocysteine insertion sequence binding
C2E15_RS00705	COG1921	L-seryl-tRNASec selenium transferase activity
C2E15_RS00710	COG0625	glutathione transferase activity
C2E15_RS00720	COG2864	formate dehydrogenase
C2E15_RS00725	COG0437	4 iron, 4 sulfur cluster binding
C2E15_RS00745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2E15_RS00750	COG2990	Protein conserved in bacteria
C2E15_RS00760	COG3722	fumarate hydratase activity
C2E15_RS00770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS00770	COG2213	PTS system mannitol-specific
C2E15_RS00785	COG2944	sequence-specific DNA binding
C2E15_RS00800	COG1846	Transcriptional regulator
C2E15_RS00805	COG1764	response to oxidative stress
C2E15_RS00810	COG2194	sulfuric ester hydrolase activity
C2E15_RS00830	COG0747	negative chemotaxis
C2E15_RS00835	COG0601	transmembrane transport
C2E15_RS00840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E15_RS00845	COG0444	Belongs to the ABC transporter superfamily
C2E15_RS00850	COG4608	Belongs to the ABC transporter superfamily
C2E15_RS00855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2E15_RS00885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2E15_RS00890	COG2194	sulfuric ester hydrolase activity
C2E15_RS00910	COG1192	Involved in chromosome partitioning
C2E15_RS00915	COG1215	transferase activity, transferring glycosyl groups
C2E15_RS00925	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2E15_RS00930	COG0457	Tetratricopeptide repeat
C2E15_RS00930	COG3118	belongs to the thioredoxin family
C2E15_RS00935	COG2200	EAL domain
C2E15_RS00935	COG2199	diguanylate cyclase activity
C2E15_RS00945	COG0612	Peptidase, M16
C2E15_RS00955	COG0625	glutathione transferase activity
C2E15_RS00960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E15_RS00965	COG2200	EAL domain
C2E15_RS00970	COG2982	Protein involved in outer membrane biogenesis
C2E15_RS00975	COG0477	Major facilitator Superfamily
C2E15_RS00980	COG1295	ribonuclease BN
C2E15_RS00985	COG0583	DNA-binding transcription factor activity
C2E15_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS00995	COG0384	phenazine biosynthesis protein PhzF
C2E15_RS01000	COG0625	glutathione transferase activity
C2E15_RS01005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2E15_RS01015	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2E15_RS01045	COG0596	Alpha beta hydrolase
C2E15_RS01055	COG3685	Protein conserved in bacteria
C2E15_RS01060	COG3729	General stress protein
C2E15_RS01065	COG1609	Transcriptional regulator
C2E15_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS01070	COG1263	PTS System
C2E15_RS01075	COG0366	Alpha amylase catalytic
C2E15_RS01085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2E15_RS01095	COG2223	nitrite transmembrane transporter activity
C2E15_RS01110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2E15_RS01120	COG0400	carboxylic ester hydrolase activity
C2E15_RS01125	COG1132	(ABC) transporter
C2E15_RS01145	COG4774	siderophore transport
C2E15_RS01150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2E15_RS01160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2E15_RS01165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2E15_RS01170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C2E15_RS01180	COG2862	Uncharacterized protein family, UPF0114
C2E15_RS01190	COG4104	PAAR repeat-containing protein
C2E15_RS01210	COG1064	alcohol dehydrogenase
C2E15_RS01215	COG3387	PFAM Glycoside hydrolase 15-related
C2E15_RS01225	COG3188	usher protein
C2E15_RS01235	COG3539	Fimbrial protein
C2E15_RS01255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E15_RS01260	COG3541	Predicted nucleotidyltransferase
C2E15_RS01265	COG1690	Belongs to the RtcB family
C2E15_RS01270	COG4650	regulator
C2E15_RS01275	COG1234	tRNA 3'-trailer cleavage
C2E15_RS01280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2E15_RS01290	COG0339	signal peptide processing
C2E15_RS01295	COG0742	ribosomal rna small subunit methyltransferase
C2E15_RS01310	COG0306	phosphate transporter
C2E15_RS01315	COG2081	HI0933 family
C2E15_RS01325	COG3710	Transcriptional regulator
C2E15_RS01335	COG1063	alcohol dehydrogenase
C2E15_RS01340	COG1546	Belongs to the CinA family
C2E15_RS01350	COG3468	outer membrane autotransporter barrel domain protein
C2E15_RS01355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2E15_RS01385	COG0535	radical SAM domain protein
C2E15_RS01395	COG2203	Gaf domain
C2E15_RS01395	COG2199	diguanylate cyclase activity
C2E15_RS01400	COG0113	porphobilinogen synthase activity
C2E15_RS01405	COG0071	Belongs to the small heat shock protein (HSP20) family
C2E15_RS01425	COG2186	Transcriptional regulator
C2E15_RS01450	COG3718	enzyme involved in inositol metabolism
C2E15_RS01460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E15_RS01465	COG3962	Belongs to the TPP enzyme family
C2E15_RS01470	COG0673	inositol 2-dehydrogenase activity
C2E15_RS01475	COG1082	Xylose isomerase domain protein TIM barrel
C2E15_RS01480	COG1082	Xylose isomerase domain protein TIM barrel
C2E15_RS01490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2E15_RS01495	COG0425	Belongs to the sulfur carrier protein TusA family
C2E15_RS01500	COG3714	YhhN family
C2E15_RS01510	COG3776	membrane
C2E15_RS01515	COG0742	ribosomal rna small subunit methyltransferase
C2E15_RS01525	COG2884	Cell division ATP-binding protein ftsE
C2E15_RS01530	COG2177	Part of the ABC transporter FtsEX involved in
C2E15_RS01535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2E15_RS01545	COG0683	leucine binding
C2E15_RS01555	COG4177	L-phenylalanine transmembrane transporter activity
C2E15_RS01580	COG0395	ABC-type sugar transport system, permease component
C2E15_RS01590	COG0584	glycerophosphoryl diester phosphodiesterase
C2E15_RS01600	COG0405	Gamma-glutamyltransferase
C2E15_RS01605	COG1247	-acetyltransferase
C2E15_RS01610	COG1741	Belongs to the pirin family
C2E15_RS01615	COG1609	Transcriptional regulator
C2E15_RS01620	COG3265	gluconokinase activity
C2E15_RS01625	COG2610	gluconate transmembrane transporter activity
C2E15_RS01630	COG2095	MarC family integral membrane protein
C2E15_RS01635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2E15_RS01645	COG1523	belongs to the glycosyl hydrolase 13 family
C2E15_RS01655	COG0297	glycogen (starch) synthase activity
C2E15_RS01660	COG0058	SHG alpha-glucan phosphorylase activity
C2E15_RS01665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2E15_RS01680	COG1349	DNA-binding transcription factor activity
C2E15_RS01685	COG2909	trisaccharide binding
C2E15_RS01690	COG0058	SHG alpha-glucan phosphorylase activity
C2E15_RS01695	COG1640	4-alpha-glucanotransferase
C2E15_RS01700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2E15_RS01700	COG0316	Belongs to the HesB IscA family
C2E15_RS01705	COG1040	competence protein
C2E15_RS01710	COG2267	carboxylic ester hydrolase activity
C2E15_RS01720	COG0366	Alpha amylase catalytic
C2E15_RS01730	COG1918	ferrous iron import across plasma membrane
C2E15_RS01735	COG2183	response to ionizing radiation
C2E15_RS01740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2E15_RS01760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2E15_RS01765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2E15_RS01770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2E15_RS01775	COG1011	Hydrolase
C2E15_RS01785	COG0494	nUDIX hydrolase
C2E15_RS01815	COG4796	Type ii and iii secretion system protein
C2E15_RS01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2E15_RS01830	COG3266	domain, Protein
C2E15_RS01840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2E15_RS01850	COG0180	Tryptophanyl-tRNA synthetase
C2E15_RS01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2E15_RS01870	COG0402	S-adenosylhomocysteine deaminase activity
C2E15_RS01885	COG0738	Major facilitator superfamily
C2E15_RS01900	COG2184	nucleotidyltransferase activity
C2E15_RS01910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2E15_RS01915	COG1289	transmembrane transporter activity
C2E15_RS01920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2E15_RS01925	COG1765	OsmC-like protein
C2E15_RS01930	COG3954	Phosphoribulokinase
C2E15_RS01935	COG3089	Belongs to the UPF0270 family
C2E15_RS01940	COG0429	hydrolase of the alpha beta-hydrolase fold
C2E15_RS01950	COG1609	Transcriptional regulator
C2E15_RS01955	COG4521	taurine ABC transporter
C2E15_RS01965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2E15_RS01970	COG2175	clavaminate synthase activity
C2E15_RS01975	COG2199	diguanylate cyclase activity
C2E15_RS01975	COG2200	EAL domain
C2E15_RS01980	COG0488	(ABC) transporter
C2E15_RS01985	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2E15_RS01990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2E15_RS01990	COG0475	glutathione-regulated potassium exporter activity
C2E15_RS01995	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2E15_RS02000	COG1047	Peptidyl-prolyl cis-trans
C2E15_RS02005	COG2900	Belongs to the SlyX family
C2E15_RS02010	COG0545	Peptidyl-prolyl cis-trans isomerase
C2E15_RS02015	COG2964	Protein conserved in bacteria
C2E15_RS02025	COG2923	Belongs to the DsrF TusC family
C2E15_RS02030	COG2168	tRNA wobble position uridine thiolation
C2E15_RS02035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2E15_RS02040	COG0049	tRNA binding
C2E15_RS02060	COG2193	ferroxidase activity
C2E15_RS02070	COG0051	transcription antitermination factor activity, RNA binding
C2E15_RS02080	COG0088	Forms part of the polypeptide exit tunnel
C2E15_RS02095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2E15_RS02110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2E15_RS02155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2E15_RS02165	COG1841	ribosomal large subunit assembly
C2E15_RS02170	COG0200	Binds to the 23S rRNA
C2E15_RS02175	COG0201	protein transport
C2E15_RS02180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2E15_RS02190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2E15_RS02195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2E15_RS02205	COG0203	ribosomal protein L17
C2E15_RS02215	COG3036	rescue of stalled ribosome
C2E15_RS02220	COG1970	mechanosensitive ion channel activity
C2E15_RS02225	COG0569	domain protein
C2E15_RS02230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2E15_RS02230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2E15_RS02235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2E15_RS02240	COG0242	peptide deformylase activity
C2E15_RS02255	COG0551	DNA topoisomerase type I activity
C2E15_RS02275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2E15_RS02310	COG1126	abc transporter atp-binding protein
C2E15_RS02315	COG0765	amino acid transport
C2E15_RS02320	COG4597	amino acid ABC transporter
C2E15_RS02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E15_RS02330	COG1560	Kdo2-lipid A biosynthetic process
C2E15_RS02350	COG2264	protein methyltransferase activity
C2E15_RS02355	COG4145	pantothenate transmembrane transporter activity
C2E15_RS02360	COG3924	membrane
C2E15_RS02365	COG0439	Biotin carboxylase
C2E15_RS02370	COG0511	ligase activity, forming carbon-carbon bonds
C2E15_RS02375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2E15_RS02380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2E15_RS02385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2E15_RS02390	COG0604	alcohol dehydrogenase
C2E15_RS02395	COG2200	EAL domain
C2E15_RS02395	COG2199	diguanylate cyclase activity
C2E15_RS02405	COG1077	Cell shape determining protein MreB Mrl
C2E15_RS02410	COG1792	Involved in formation and maintenance of cell shape
C2E15_RS02415	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2E15_RS02425	COG1530	ribonuclease E activity
C2E15_RS02430	COG3164	Protein of unknown function
C2E15_RS02435	COG0312	modulator of DNA gyrase
C2E15_RS02440	COG0583	DNA-binding transcription factor activity
C2E15_RS02450	COG1566	PFAM secretion protein HlyD family protein
C2E15_RS02455	COG1289	transmembrane transporter activity
C2E15_RS02465	COG2732	(Barnase) inhibitor
C2E15_RS02485	COG1438	arginine binding
C2E15_RS02495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2E15_RS02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2E15_RS02505	COG3105	Protein conserved in bacteria
C2E15_RS02510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2E15_RS02515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2E15_RS02520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2E15_RS02525	COG0625	glutathione transferase activity
C2E15_RS02530	COG2969	positive regulation of protein catabolic process
C2E15_RS02535	COG0493	'glutamate synthase
C2E15_RS02540	COG0067	glutamate synthase
C2E15_RS02540	COG0069	glutamate synthase activity
C2E15_RS02540	COG0070	glutamate synthase
C2E15_RS02545	COG5002	protein histidine kinase activity
C2E15_RS02545	COG2198	Histidine kinase
C2E15_RS02545	COG0784	Response regulator, receiver
C2E15_RS02550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E15_RS02555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS02560	COG1660	Displays ATPase and GTPase activities
C2E15_RS02570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2E15_RS02575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2E15_RS02580	COG1137	ATPase activity
C2E15_RS02585	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2E15_RS02590	COG3117	lipopolysaccharide transmembrane transporter activity
C2E15_RS02595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2E15_RS02605	COG0530	calcium, potassium:sodium antiporter activity
C2E15_RS02615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2E15_RS02620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2E15_RS02625	COG2854	intermembrane phospholipid transfer
C2E15_RS02630	COG3113	response to antibiotic
C2E15_RS02635	COG5007	Belongs to the BolA IbaG family
C2E15_RS02640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2E15_RS02645	COG3423	Transcriptional regulator
C2E15_RS02650	COG0142	geranyltranstransferase activity
C2E15_RS02655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2E15_RS02660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2E15_RS02665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2E15_RS02670	COG4592	Periplasmic binding protein
C2E15_RS02675	COG2382	esterase
C2E15_RS02680	COG4771	TonB-dependent receptor
C2E15_RS02685	COG0642	Histidine kinase
C2E15_RS02690	COG0745	RESPONSE REGULATOR receiver
C2E15_RS02695	COG2027	D-alanyl-D-alanine carboxypeptidase
C2E15_RS02705	COG1534	Rna-binding protein
C2E15_RS02715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2E15_RS02725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2E15_RS02730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2E15_RS02735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2E15_RS02755	COG0195	Participates in both transcription termination and antitermination
C2E15_RS02765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2E15_RS02770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2E15_RS02775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2E15_RS02790	COG0513	Belongs to the DEAD box helicase family
C2E15_RS02795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2E15_RS02800	COG0826	peptidase U32
C2E15_RS02805	COG0826	peptidase U32
C2E15_RS02810	COG3154	lipid carrier protein
C2E15_RS02815	COG3153	acetyltransferase
C2E15_RS02820	COG2827	Endonuclease containing a URI domain
C2E15_RS02825	COG3787	Belongs to the UPF0306 family
C2E15_RS02830	COG0693	protein deglycase activity
C2E15_RS02835	COG0702	epimerase
C2E15_RS02840	COG0701	Predicted permease
C2E15_RS02845	COG0602	queuosine metabolic process
C2E15_RS02855	COG0366	Alpha amylase catalytic
C2E15_RS02860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C2E15_RS02870	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2E15_RS02885	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2E15_RS02915	COG2927	DNA polymerase III (CHI subunit)
C2E15_RS02920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2E15_RS02925	COG0795	lipopolysaccharide-transporting ATPase activity
C2E15_RS02930	COG0795	lipopolysaccharide-transporting ATPase activity
C2E15_RS02950	COG2733	membrane
C2E15_RS02955	COG3710	Transcriptional regulator
C2E15_RS02990	COG0582	viral genome integration into host DNA
C2E15_RS03030	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2E15_RS03045	COG3012	SEC-C Motif Domain Protein
C2E15_RS03045	COG3318	Belongs to the UPF0149 family
C2E15_RS03065	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2E15_RS03105	COG1609	Transcriptional regulator
C2E15_RS03115	COG2723	6-phospho-beta-galactosidase activity
C2E15_RS03130	COG2211	Major facilitator Superfamily
C2E15_RS03135	COG1472	Belongs to the glycosyl hydrolase 3 family
C2E15_RS03155	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2E15_RS03155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E15_RS03160	COG2197	response regulator
C2E15_RS03205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2E15_RS03215	COG4794	Type iii secretion
C2E15_RS03225	COG4792	protein secretion
C2E15_RS03310	COG1309	transcriptional regulator
C2E15_RS03320	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2E15_RS03320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2E15_RS03335	COG3715	PTS system
C2E15_RS03340	COG3716	PTS system mannose fructose sorbose family IID component
C2E15_RS03345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2E15_RS03355	COG2226	methyltransferase
C2E15_RS03360	COG5455	response to cobalt ion
C2E15_RS03370	COG0673	inositol 2-dehydrogenase activity
C2E15_RS03375	COG1126	abc transporter atp-binding protein
C2E15_RS03385	COG1609	Transcriptional regulator
C2E15_RS03395	COG1070	Carbohydrate kinase
C2E15_RS03405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2E15_RS03410	COG1942	4-Oxalocrotonate Tautomerase
C2E15_RS03420	COG0840	transmembrane signaling receptor activity
C2E15_RS03435	COG0671	phosphoesterase, PA-phosphatase related
C2E15_RS03450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2E15_RS03455	COG4114	ferric iron reductase
C2E15_RS03460	COG3706	GGDEF domain
C2E15_RS03485	COG2813	Specifically methylates the guanine in position
C2E15_RS03490	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2E15_RS03495	COG0456	acetyltransferase
C2E15_RS03500	COG1011	Hydrolase
C2E15_RS03625	COG0515	serine threonine protein kinase
C2E15_RS03645	COG4104	PAAR repeat-containing protein
C2E15_RS03650	COG1397	ADP-ribosylglycohydrolase
C2E15_RS03750	COG3209	COG3209 Rhs family protein
C2E15_RS03875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2E15_RS03880	COG2823	Periplasmic or secreted lipoprotein
C2E15_RS03885	COG5487	UPF0391 membrane protein
C2E15_RS03895	COG4667	esterase of the alpha-beta hydrolase superfamily
C2E15_RS03900	COG0084	hydrolase, TatD family'
C2E15_RS03915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2E15_RS03920	COG0813	purine-nucleoside phosphorylase activity
C2E15_RS03925	COG3726	membrane protein affecting hemolysin expression
C2E15_RS03930	COG0560	Phosphoserine phosphatase
C2E15_RS03935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2E15_RS03960	COG0488	(ABC) transporter
C2E15_RS03965	COG1349	DNA-binding transcription factor activity
C2E15_RS03970	COG0741	lytic transglycosylase activity
C2E15_RS03980	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C2E15_RS03985	COG0406	alpha-ribazole phosphatase activity
C2E15_RS03990	COG2207	Transcriptional regulator
C2E15_RS03990	COG3708	Transcriptional regulator
C2E15_RS03995	COG3045	CreA protein
C2E15_RS04000	COG0745	RESPONSE REGULATOR receiver
C2E15_RS04005	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2E15_RS04015	COG0527	aspartate kinase activity
C2E15_RS04015	COG0460	homoserine dehydrogenase
C2E15_RS04040	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2E15_RS04065	COG0583	DNA-binding transcription factor activity
C2E15_RS04085	COG0196	riboflavin kinase activity
C2E15_RS04090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2E15_RS04095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2E15_RS04100	COG1047	Peptidyl-prolyl cis-trans
C2E15_RS04105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2E15_RS04110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2E15_RS04115	COG0505	Belongs to the CarA family
C2E15_RS04150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2E15_RS04160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2E15_RS04165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2E15_RS04180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2E15_RS04185	COG0564	pseudouridine synthase activity
C2E15_RS04190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2E15_RS04195	COG0417	DNA replication proofreading
C2E15_RS04210	COG0586	Pfam SNARE associated Golgi protein
C2E15_RS04220	COG1178	ABC-type Fe3 transport system permease component
C2E15_RS04225	COG4143	(ABC) transporter
C2E15_RS04235	COG2814	Major facilitator Superfamily
C2E15_RS04245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2E15_RS04250	COG0473	3-isopropylmalate dehydrogenase activity
C2E15_RS04255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2E15_RS04260	COG0028	Belongs to the TPP enzyme family
C2E15_RS04275	COG2001	Belongs to the MraZ family
C2E15_RS04280	COG0275	rRNA processing
C2E15_RS04285	COG3116	cell division
C2E15_RS04290	COG0768	penicillin binding
C2E15_RS04295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2E15_RS04300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2E15_RS04305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2E15_RS04315	COG0772	Belongs to the SEDS family
C2E15_RS04320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2E15_RS04330	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2E15_RS04340	COG0849	cell division
C2E15_RS04345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2E15_RS04380	COG0494	nUDIX hydrolase
C2E15_RS04390	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2E15_RS04400	COG0516	GMP reductase activity
C2E15_RS04405	COG1459	type II secretion system
C2E15_RS04410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2E15_RS04415	COG4969	Belongs to the N-Me-Phe pilin family
C2E15_RS04430	COG3725	Membrane protein required for beta-lactamase induction
C2E15_RS04435	COG3940	Belongs to the glycosyl hydrolase 43 family
C2E15_RS04440	COG2211	Major facilitator Superfamily
C2E15_RS04450	COG2186	Transcriptional regulator
C2E15_RS04455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2E15_RS04460	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2E15_RS04465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E15_RS04490	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2E15_RS04495	COG3479	Phenolic acid decarboxylase
C2E15_RS04525	COG1349	DNA-binding transcription factor activity
C2E15_RS04535	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2E15_RS04545	COG2132	Multicopper oxidase
C2E15_RS04555	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2E15_RS04560	COG0288	reversible hydration of carbon dioxide
C2E15_RS04565	COG1131	(ABC) transporter
C2E15_RS04570	COG0842	Transport permease protein
C2E15_RS04580	COG0110	maltose O-acetyltransferase activity
C2E15_RS04590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2E15_RS04595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2E15_RS04600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2E15_RS04605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2E15_RS04620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2E15_RS04630	COG1489	DNA binding
C2E15_RS04635	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2E15_RS04640	COG1643	Atp-dependent helicase
C2E15_RS04645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E15_RS04650	COG0840	transmembrane signaling receptor activity
C2E15_RS04655	COG4774	siderophore transport
C2E15_RS04660	COG1120	ATPase activity
C2E15_RS04665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2E15_RS04670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E15_RS04675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2E15_RS04685	COG0316	Belongs to the HesB IscA family
C2E15_RS04700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2E15_RS04715	COG3835	regulator
C2E15_RS04730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2E15_RS04745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2E15_RS04750	COG0528	UMP kinase activity
C2E15_RS04760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2E15_RS04770	COG0575	Belongs to the CDS family
C2E15_RS04780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2E15_RS04785	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2E15_RS04790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2E15_RS04795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2E15_RS04805	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2E15_RS04820	COG0825	malonyl-CoA metabolic process
C2E15_RS04825	COG1982	Orn Lys Arg decarboxylase major
C2E15_RS04830	COG0346	lactoylglutathione lyase activity
C2E15_RS04835	COG0037	tRNA processing
C2E15_RS04845	COG4568	rho-dependent transcription termination
C2E15_RS04855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2E15_RS04865	COG1720	tRNA m6t6A37 methyltransferase activity
C2E15_RS04880	COG2011	ABC-type metal ion transport system permease component
C2E15_RS04890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2E15_RS04925	COG0583	DNA-binding transcription factor activity
C2E15_RS04930	COG3021	interspecies interaction between organisms
C2E15_RS04935	COG1388	LysM domain
C2E15_RS04935	COG0741	lytic transglycosylase activity
C2E15_RS04940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2E15_RS04955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2E15_RS04965	COG1953	Uracil, thiamine, allantoin
C2E15_RS05015	COG0765	amino acid transport
C2E15_RS05020	COG0765	amino acid transport
C2E15_RS05025	COG1126	abc transporter atp-binding protein
C2E15_RS05030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2E15_RS05045	COG2351	hydroxyisourate hydrolase activity
C2E15_RS05050	COG2233	PERMEase
C2E15_RS05060	COG2207	Transcriptional regulator
C2E15_RS05065	COG0477	Major facilitator Superfamily
C2E15_RS05080	COG1022	Amp-dependent synthetase and ligase
C2E15_RS05090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2E15_RS05095	COG0436	Aminotransferase
C2E15_RS05105	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C2E15_RS05110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2E15_RS05130	COG3657	addiction module killer protein
C2E15_RS05140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2E15_RS05145	COG0121	glutamine amidotransferase
C2E15_RS05150	COG3034	peptidoglycan biosynthetic process
C2E15_RS05175	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E15_RS05180	COG1129	ABC transporter
C2E15_RS05185	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2E15_RS05190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2E15_RS05195	COG1073	alpha beta
C2E15_RS05210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2E15_RS05215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2E15_RS05265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2E15_RS05270	COG1349	DNA-binding transcription factor activity
C2E15_RS05280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2E15_RS05285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2E15_RS05290	COG1882	Formate acetyltransferase
C2E15_RS05300	COG1121	(ABC) transporter
C2E15_RS05305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2E15_RS05310	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2E15_RS05320	COG1263	PTS System
C2E15_RS05320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS05320	COG2190	(PTS) system
C2E15_RS05325	COG1609	Transcriptional regulator
C2E15_RS05330	COG0598	Magnesium transport protein CorA
C2E15_RS05350	COG0513	Belongs to the DEAD box helicase family
C2E15_RS05355	COG3615	Tellurite resistance protein tehB
C2E15_RS05360	COG4604	ABC transporter, ATP-binding protein
C2E15_RS05365	COG4605	iron ion homeostasis
C2E15_RS05375	COG4607	ABC-type enterochelin transport system periplasmic component
C2E15_RS05410	COG0443	Heat shock 70 kDa protein
C2E15_RS05435	COG3604	Transcriptional regulator
C2E15_RS05455	COG2211	Major facilitator Superfamily
C2E15_RS05470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2E15_RS05490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2E15_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS05500	COG0561	phosphatase activity
C2E15_RS05505	COG1733	regulation of RNA biosynthetic process
C2E15_RS05510	COG1064	alcohol dehydrogenase
C2E15_RS05515	COG2155	Conserved Protein
C2E15_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
C2E15_RS05530	COG2194	sulfuric ester hydrolase activity
C2E15_RS05570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E15_RS05575	COG0601	transmembrane transport
C2E15_RS05580	COG0747	negative chemotaxis
C2E15_RS05590	COG5001	Diguanylate cyclase
C2E15_RS05600	COG0456	acetyltransferase
C2E15_RS05615	COG1278	Cold shock
C2E15_RS05620	COG3729	General stress protein
C2E15_RS05630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2E15_RS05640	COG2323	membrane
C2E15_RS05645	COG1671	Belongs to the UPF0178 family
C2E15_RS05650	COG3416	Protein conserved in bacteria
C2E15_RS05655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2E15_RS05665	COG4126	flavin adenine dinucleotide binding
C2E15_RS05675	COG2974	May be involved in recombination
C2E15_RS05680	COG1940	carbohydrate kinase activity
C2E15_RS05690	COG0419	ATPase involved in DNA repair
C2E15_RS05695	COG0420	3'-5' exonuclease activity
C2E15_RS05700	COG0745	RESPONSE REGULATOR receiver
C2E15_RS05715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2E15_RS05730	COG0668	transmembrane transport
C2E15_RS05735	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C2E15_RS05750	COG1862	Preprotein translocase
C2E15_RS05755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2E15_RS05760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2E15_RS05765	COG4238	major outer membrane lipoprotein
C2E15_RS05770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2E15_RS05775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2E15_RS05775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2E15_RS05780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2E15_RS05785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2E15_RS05790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2E15_RS05795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2E15_RS05800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2E15_RS05805	COG0142	geranyltranstransferase activity
C2E15_RS05815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2E15_RS05815	COG0301	tRNA thio-modification
C2E15_RS05825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2E15_RS05830	COG1666	GTP binding
C2E15_RS05835	COG2814	Major facilitator Superfamily
C2E15_RS05840	COG0109	protoheme IX farnesyltransferase activity
C2E15_RS05845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2E15_RS05850	COG1845	cytochrome c oxidase, subunit III
C2E15_RS05855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2E15_RS05860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2E15_RS05865	COG2223	nitrite transmembrane transporter activity
C2E15_RS05870	COG3056	Lipoprotein
C2E15_RS05875	COG0271	Belongs to the BolA IbaG family
C2E15_RS05900	COG0776	regulation of translation
C2E15_RS05905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2E15_RS05910	COG1555	photosystem II stabilization
C2E15_RS05915	COG0824	Thioesterase
C2E15_RS05925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2E15_RS05930	COG1522	sequence-specific DNA binding
C2E15_RS05935	COG1132	(ABC) transporter
C2E15_RS05940	COG1132	(ABC) transporter
C2E15_RS05945	COG0347	Belongs to the P(II) protein family
C2E15_RS05950	COG0004	ammonium transporteR
C2E15_RS05955	COG1946	Acyl-CoA thioesterase
C2E15_RS05960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2E15_RS05965	COG3695	enzyme binding
C2E15_RS05990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2E15_RS05995	COG0254	rRNA binding
C2E15_RS06000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2E15_RS06005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2E15_RS06010	COG1309	transcriptional regulator
C2E15_RS06020	COG2261	transglycosylase associated protein
C2E15_RS06025	COG2832	Protein of unknown function (DUF454)
C2E15_RS06030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2E15_RS06040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2E15_RS06045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2E15_RS06055	COG0563	adenylate kinase activity
C2E15_RS06060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2E15_RS06065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E15_RS06070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2E15_RS06070	COG4651	solute:proton antiporter activity
C2E15_RS06075	COG0737	Belongs to the 5'-nucleotidase family
C2E15_RS06085	COG0583	DNA-binding transcription factor activity
C2E15_RS06095	COG3735	TraB family
C2E15_RS06100	COG2217	Heavy metal translocating P-type atpase
C2E15_RS06105	COG2314	TM2 domain
C2E15_RS06115	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2E15_RS06120	COG0330	HflC and HflK could
C2E15_RS06125	COG3118	belongs to the thioredoxin family
C2E15_RS06130	COG0300	oxidoreductase activity
C2E15_RS06135	COG2755	lipolytic protein G-D-S-L family
C2E15_RS06140	COG4181	ATPase activity
C2E15_RS06145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2E15_RS06150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2E15_RS06155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2E15_RS06165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2E15_RS06170	COG0215	cysteine-tRNA ligase activity
C2E15_RS06175	COG1349	DNA-binding transcription factor activity
C2E15_RS06180	COG0673	inositol 2-dehydrogenase activity
C2E15_RS06185	COG2501	S4 domain
C2E15_RS06190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2E15_RS06200	COG1289	transmembrane transporter activity
C2E15_RS06205	COG0583	DNA-binding transcription factor activity
C2E15_RS06215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2E15_RS06220	COG2610	gluconate transmembrane transporter activity
C2E15_RS06235	COG0583	DNA-binding transcription factor activity
C2E15_RS06245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2E15_RS06250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2E15_RS06255	COG3383	formate dehydrogenase (NAD+) activity
C2E15_RS06260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2E15_RS06265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2E15_RS06275	COG3260	NADH ubiquinone oxidoreductase 20
C2E15_RS06280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2E15_RS06285	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2E15_RS06285	COG3261	NADH dehydrogenase
C2E15_RS06290	COG0650	Formate hydrogenlyase subunit 4
C2E15_RS06295	COG0651	ATP synthesis coupled electron transport
C2E15_RS06300	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2E15_RS06310	COG0375	protein maturation
C2E15_RS06315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2E15_RS06320	COG0298	carbon dioxide binding
C2E15_RS06325	COG0409	Hydrogenase expression formation protein
C2E15_RS06330	COG0309	Hydrogenase expression formation protein (HypE)
C2E15_RS06340	COG0561	phosphatase activity
C2E15_RS06345	COG1454	alcohol dehydrogenase
C2E15_RS06350	COG2610	gluconate transmembrane transporter activity
C2E15_RS06375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2E15_RS06380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2E15_RS06385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2E15_RS06390	COG0321	lipoyl(octanoyl) transferase activity
C2E15_RS06400	COG1686	Belongs to the peptidase S11 family
C2E15_RS06405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2E15_RS06410	COG0772	Belongs to the SEDS family
C2E15_RS06415	COG0768	penicillin binding
C2E15_RS06420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2E15_RS06425	COG0799	negative regulation of ribosome biogenesis
C2E15_RS06435	COG1466	dna polymerase III delta subunit
C2E15_RS06440	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C2E15_RS06445	COG0495	leucyl-tRNA aminoacylation
C2E15_RS06450	COG2888	peptidyl-tyrosine sulfation
C2E15_RS06455	COG1126	abc transporter atp-binding protein
C2E15_RS06460	COG0765	amino acid transport
C2E15_RS06465	COG0765	amino acid transport
C2E15_RS06475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2E15_RS06480	COG4535	Mg2 and Co2 transporter CorC
C2E15_RS06485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2E15_RS06490	COG1702	phosphate starvation-inducible protein PhoH
C2E15_RS06500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2E15_RS06540	COG0367	asparagine synthase
C2E15_RS06545	COG1846	Transcriptional regulator
C2E15_RS06545	COG1940	carbohydrate kinase activity
C2E15_RS06550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2E15_RS06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS06560	COG1263	PTS System
C2E15_RS06560	COG2190	(PTS) system
C2E15_RS06565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2E15_RS06570	COG0814	amino acid
C2E15_RS06575	COG0735	belongs to the Fur family
C2E15_RS06590	COG0596	Alpha beta hydrolase
C2E15_RS06595	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2E15_RS06600	COG0033	Phosphoglucomutase
C2E15_RS06605	COG0745	RESPONSE REGULATOR receiver
C2E15_RS06615	COG3272	Protein of unknown function (DUF1722)
C2E15_RS06630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2E15_RS06635	COG1984	allophanate hydrolase subunit 2
C2E15_RS06655	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2E15_RS06665	COG0372	Belongs to the citrate synthase family
C2E15_RS06670	COG2009	succinate dehydrogenase
C2E15_RS06675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2E15_RS06680	COG1053	succinate dehydrogenase
C2E15_RS06685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2E15_RS06690	COG0567	Dehydrogenase, E1 component
C2E15_RS06695	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2E15_RS06700	COG0045	succinate-CoA ligase (ADP-forming) activity
C2E15_RS06705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2E15_RS06715	COG1271	oxidase subunit
C2E15_RS06720	COG1294	oxidase, subunit
C2E15_RS06725	COG4890	Cyd operon protein YbgT
C2E15_RS06730	COG3790	cyd operon protein YbgE
C2E15_RS06735	COG0824	Thioesterase
C2E15_RS06740	COG0811	peptide transport
C2E15_RS06745	COG0848	biopolymer transport protein
C2E15_RS06750	COG3064	Membrane
C2E15_RS06750	COG3064	Membrane
C2E15_RS06755	COG0823	Involved in the tonB-independent uptake of proteins
C2E15_RS06760	COG2885	chlorophyll binding
C2E15_RS06765	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2E15_RS06810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2E15_RS06815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2E15_RS06825	COG1230	cation diffusion facilitator family transporter
C2E15_RS06830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E15_RS06830	COG2205	protein histidine kinase activity
C2E15_RS06845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2E15_RS06850	COG0588	phosphoglycerate mutase activity
C2E15_RS06855	COG2017	converts alpha-aldose to the beta-anomer
C2E15_RS06865	COG1085	galactose-1-phosphate uridylyltransferase
C2E15_RS06870	COG1119	ATPase activity
C2E15_RS06875	COG2005	Transcriptional regulator
C2E15_RS06875	COG3585	molybdate ion transport
C2E15_RS06885	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2E15_RS06890	COG4149	molybdate abc transporter
C2E15_RS06900	COG0561	phosphatase activity
C2E15_RS06905	COG2706	6-phosphogluconolactonase activity
C2E15_RS06915	COG1881	PFAM PEBP family protein
C2E15_RS06925	COG2130	NADP-dependent
C2E15_RS06935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2E15_RS06940	COG0156	8-amino-7-oxononanoate synthase activity
C2E15_RS06975	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2E15_RS06980	COG0315	cyclic pyranopterin monophosphate synthase activity
C2E15_RS06985	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2E15_RS07005	COG0840	transmembrane signaling receptor activity
C2E15_RS07010	COG0670	Belongs to the BI1 family
C2E15_RS07015	COG0392	lysyltransferase activity
C2E15_RS07020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E15_RS07025	COG3568	Endonuclease Exonuclease Phosphatase
C2E15_RS07035	COG0513	Belongs to the DEAD box helicase family
C2E15_RS07040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2E15_RS07045	COG0477	Major facilitator Superfamily
C2E15_RS07050	COG0306	phosphate transporter
C2E15_RS07060	COG1376	ErfK ybiS ycfS ynhG family protein
C2E15_RS07065	COG3387	PFAM Glycoside hydrolase 15-related
C2E15_RS07070	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS07075	COG4619	ABC transporter
C2E15_RS07080	COG0390	transport system, permease component
C2E15_RS07085	COG0586	Pfam SNARE associated Golgi protein
C2E15_RS07095	COG1686	Belongs to the peptidase S11 family
C2E15_RS07105	COG3264	Mechanosensitive ion channel
C2E15_RS07105	COG1511	domain protein
C2E15_RS07110	COG0277	FAD linked oxidase domain protein
C2E15_RS07115	COG1472	Belongs to the glycosyl hydrolase 3 family
C2E15_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS07130	COG0477	Major facilitator Superfamily
C2E15_RS07135	COG0583	DNA-binding transcription factor activity
C2E15_RS07140	COG3685	Protein conserved in bacteria
C2E15_RS07160	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2E15_RS07165	COG0477	Major facilitator Superfamily
C2E15_RS07170	COG1732	Glycine betaine
C2E15_RS07175	COG1174	glycine betaine transport
C2E15_RS07180	COG1125	glycine betaine transport
C2E15_RS07185	COG1174	glycine betaine transport
C2E15_RS07210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2E15_RS07215	COG1473	amidohydrolase
C2E15_RS07220	COG0667	Aldo Keto reductase
C2E15_RS07225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2E15_RS07230	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2E15_RS07235	COG0668	transmembrane transport
C2E15_RS07240	COG1126	abc transporter atp-binding protein
C2E15_RS07245	COG0765	amino acid transport
C2E15_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E15_RS07255	COG0783	Belongs to the Dps family
C2E15_RS07265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2E15_RS07275	COG1321	iron dependent repressor
C2E15_RS07280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2E15_RS07285	COG1566	PFAM secretion protein HlyD family protein
C2E15_RS07300	COG2814	Major facilitator Superfamily
C2E15_RS07305	COG0488	(ABC) transporter
C2E15_RS07310	COG4251	negative regulation of phosphorylation
C2E15_RS07310	COG2203	Gaf domain
C2E15_RS07310	COG3706	GGDEF domain
C2E15_RS07310	COG5001	Diguanylate cyclase
C2E15_RS07325	COG0303	'Molybdopterin
C2E15_RS07330	COG1446	asparaginase
C2E15_RS07335	COG4172	Belongs to the ABC transporter superfamily
C2E15_RS07340	COG0747	negative chemotaxis
C2E15_RS07345	COG0601	transmembrane transport
C2E15_RS07355	COG0673	inositol 2-dehydrogenase activity
C2E15_RS07365	COG2133	pyrroloquinoline quinone binding
C2E15_RS07375	COG1686	Belongs to the peptidase S11 family
C2E15_RS07380	COG0814	amino acid
C2E15_RS07385	COG0671	phosphoesterase, PA-phosphatase related
C2E15_RS07415	COG0778	Nitroreductase
C2E15_RS07430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2E15_RS07440	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2E15_RS07445	COG1177	transmembrane transport
C2E15_RS07460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E15_RS07465	COG4160	amino acid transport
C2E15_RS07470	COG4215	(ABC) transporter
C2E15_RS07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E15_RS07480	COG1126	abc transporter atp-binding protein
C2E15_RS07490	COG0393	Putative heavy-metal-binding
C2E15_RS07495	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2E15_RS07500	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2E15_RS07505	COG0028	Belongs to the TPP enzyme family
C2E15_RS07510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2E15_RS07520	COG2431	L-lysine efflux transmembrane transporter activity
C2E15_RS07535	COG1278	Cold shock
C2E15_RS07540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2E15_RS07545	COG0542	response to heat
C2E15_RS07550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2E15_RS07555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2E15_RS07560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2E15_RS07565	COG4988	ABC transporter
C2E15_RS07570	COG0492	ferredoxin-NADP+ reductase activity
C2E15_RS07585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2E15_RS07590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2E15_RS07595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2E15_RS07600	COG0477	Major facilitator Superfamily
C2E15_RS07605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2E15_RS07610	COG1882	Formate acetyltransferase
C2E15_RS07615	COG2116	formate transmembrane transporter activity
C2E15_RS07620	COG1944	ATP diphosphatase activity
C2E15_RS07625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2E15_RS07640	COG0539	negative regulation of cytoplasmic translation
C2E15_RS07650	COG0658	competence protein
C2E15_RS07650	COG2333	competence protein COMEC
C2E15_RS07665	COG3214	Protein conserved in bacteria
C2E15_RS07670	COG2835	tetraacyldisaccharide 4'-kinase activity
C2E15_RS07675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2E15_RS07680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2E15_RS07685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2E15_RS07690	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
C2E15_RS07695	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2E15_RS07705	COG2989	Protein conserved in bacteria
C2E15_RS07710	COG3108	Peptidase M15
C2E15_RS07715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2E15_RS07720	COG1448	Aminotransferase
C2E15_RS07735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2E15_RS07740	COG0308	aminopeptidase N
C2E15_RS07750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2E15_RS07760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2E15_RS07765	COG0431	NADPH-dependent FMN reductase
C2E15_RS07770	COG0167	dihydroorotate dehydrogenase activity
C2E15_RS07780	COG3217	Mosc domain protein beta barrel domain protein
C2E15_RS07780	COG0633	Ferredoxin
C2E15_RS07785	COG0116	Belongs to the methyltransferase superfamily
C2E15_RS07785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2E15_RS07790	COG0488	(ABC) transporter
C2E15_RS07795	COG2995	paraquat-inducible protein a
C2E15_RS07800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2E15_RS07800	COG3008	intermembrane lipid transfer
C2E15_RS07805	COG3009	Protein conserved in bacteria
C2E15_RS07810	COG3130	regulation of translation
C2E15_RS07815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2E15_RS07820	COG1067	ATP-dependent peptidase activity
C2E15_RS07825	COG3120	sequence-specific DNA binding
C2E15_RS07840	COG3070	regulator of competence-specific genes
C2E15_RS07845	COG1289	transmembrane transporter activity
C2E15_RS07850	COG3304	Inner membrane component domain
C2E15_RS07855	COG0210	DNA helicase
C2E15_RS07870	COG1832	CoA-binding protein
C2E15_RS07880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2E15_RS07895	COG0670	Belongs to the BI1 family
C2E15_RS07915	COG1012	belongs to the aldehyde dehydrogenase family
C2E15_RS07935	COG2233	PERMEase
C2E15_RS07940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2E15_RS07945	COG2267	carboxylic ester hydrolase activity
C2E15_RS07950	COG0251	oxidation-reduction process
C2E15_RS07965	COG1309	transcriptional regulator
C2E15_RS07975	COG1113	amino acid transport
C2E15_RS07985	COG2197	response regulator
C2E15_RS07995	COG3136	membrane protein required for alginate biosynthesis
C2E15_RS08005	COG2197	response regulator
C2E15_RS08015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2E15_RS08040	COG0659	secondary active sulfate transmembrane transporter activity
C2E15_RS08085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2E15_RS08090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E15_RS08110	COG5645	(Lipo)protein
C2E15_RS08120	COG1560	Kdo2-lipid A biosynthetic process
C2E15_RS08125	COG1902	pentaerythritol trinitrate reductase activity
C2E15_RS08130	COG1054	Belongs to the UPF0176 family
C2E15_RS08135	COG2353	YceI-like domain
C2E15_RS08140	COG3038	cytochrome b561
C2E15_RS08145	COG0477	Major facilitator Superfamily
C2E15_RS08170	COG0418	dihydroorotase activity
C2E15_RS08180	COG2999	glutathione oxidoreductase activity
C2E15_RS08190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2E15_RS08200	COG0728	peptidoglycan biosynthetic process
C2E15_RS08205	COG3418	PFAM FlgN family protein
C2E15_RS08215	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2E15_RS08220	COG1815	bacterial-type flagellum-dependent cell motility
C2E15_RS08225	COG1558	bacterial-type flagellum-dependent cell motility
C2E15_RS08230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2E15_RS08235	COG1749	Flagellar hook protein flgE
C2E15_RS08265	COG1256	bacterial-type flagellum assembly
C2E15_RS08275	COG1530	ribonuclease E activity
C2E15_RS08280	COG0564	pseudouridine synthase activity
C2E15_RS08285	COG0424	maF-like protein
C2E15_RS08290	COG1399	metal-binding, possibly nucleic acid-binding protein
C2E15_RS08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2E15_RS08300	COG0416	fatty acid biosynthetic process
C2E15_RS08305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2E15_RS08310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2E15_RS08325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2E15_RS08330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2E15_RS08335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2E15_RS08345	COG0470	DNA polymerase III
C2E15_RS08350	COG0084	hydrolase, TatD family'
C2E15_RS08355	COG1263	PTS System
C2E15_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS08375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2E15_RS08385	COG0537	adenosine 5'-monophosphoramidase activity
C2E15_RS08390	COG5633	Lipoprotein
C2E15_RS08395	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C2E15_RS08405	COG1472	Belongs to the glycosyl hydrolase 3 family
C2E15_RS08415	COG1252	NADH dehydrogenase
C2E15_RS08420	COG3134	Outer membrane lipoprotein
C2E15_RS08425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2E15_RS08435	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2E15_RS08445	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2E15_RS08450	COG1940	carbohydrate kinase activity
C2E15_RS08455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2E15_RS08460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2E15_RS08465	COG1177	transmembrane transport
C2E15_RS08470	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2E15_RS08485	COG2850	peptidyl-arginine hydroxylation
C2E15_RS08490	COG2205	protein histidine kinase activity
C2E15_RS08495	COG0745	RESPONSE REGULATOR receiver
C2E15_RS08500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2E15_RS08505	COG2915	High frequency lysogenization protein hflD homolog
C2E15_RS08510	COG0482	sulfurtransferase activity
C2E15_RS08520	COG1187	pseudouridine synthase activity
C2E15_RS08525	COG0538	isocitrate dehydrogenase activity
C2E15_RS08555	COG0583	DNA-binding transcription factor activity
C2E15_RS08560	COG1063	alcohol dehydrogenase
C2E15_RS08565	COG2267	carboxylic ester hydrolase activity
C2E15_RS08580	COG1959	2 iron, 2 sulfur cluster binding
C2E15_RS08585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2E15_RS08590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E15_RS08595	COG1120	ATPase activity
C2E15_RS08610	COG0583	DNA-binding transcription factor activity
C2E15_RS08630	COG0668	transmembrane transport
C2E15_RS08655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2E15_RS08655	COG0456	acetyltransferase
C2E15_RS08705	COG0583	DNA-binding transcription factor activity
C2E15_RS08720	COG0814	amino acid
C2E15_RS08725	COG2203	Gaf domain
C2E15_RS08725	COG3706	GGDEF domain
C2E15_RS08725	COG4251	negative regulation of phosphorylation
C2E15_RS08725	COG5001	Diguanylate cyclase
C2E15_RS08755	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
C2E15_RS08765	COG0673	inositol 2-dehydrogenase activity
C2E15_RS08790	COG0583	DNA-binding transcription factor activity
C2E15_RS08805	COG0604	alcohol dehydrogenase
C2E15_RS08810	COG0668	transmembrane transport
C2E15_RS08825	COG1082	Xylose isomerase domain protein TIM barrel
C2E15_RS08845	COG3546	catalase activity
C2E15_RS08875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2E15_RS08880	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS08920	COG2011	ABC-type metal ion transport system permease component
C2E15_RS08930	COG1464	Belongs to the NlpA lipoprotein family
C2E15_RS08955	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2E15_RS08955	COG1902	pentaerythritol trinitrate reductase activity
C2E15_RS08960	COG0583	DNA-binding transcription factor activity
C2E15_RS08985	COG0747	negative chemotaxis
C2E15_RS08990	COG1064	alcohol dehydrogenase
C2E15_RS08995	COG1113	amino acid transport
C2E15_RS09000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2E15_RS09035	COG0840	transmembrane signaling receptor activity
C2E15_RS09045	COG1652	LysM domain
C2E15_RS09110	COG0668	transmembrane transport
C2E15_RS09115	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2E15_RS09120	COG4575	ribosome binding
C2E15_RS09125	COG2261	transglycosylase associated protein
C2E15_RS09130	COG1733	regulation of RNA biosynthetic process
C2E15_RS09135	COG0702	epimerase
C2E15_RS09140	COG4774	siderophore transport
C2E15_RS09145	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2E15_RS09170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2E15_RS09175	COG3381	protein complex oligomerization
C2E15_RS09190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2E15_RS09190	COG0519	Catalyzes the synthesis of GMP from XMP
C2E15_RS09215	COG0840	transmembrane signaling receptor activity
C2E15_RS09220	COG0583	DNA-binding transcription factor activity
C2E15_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS09295	COG3209	COG3209 Rhs family protein
C2E15_RS09295	COG4104	PAAR repeat-containing protein
C2E15_RS09320	COG0012	GTP binding
C2E15_RS09330	COG0193	aminoacyl-tRNA hydrolase activity
C2E15_RS09355	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2E15_RS09360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2E15_RS09365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2E15_RS09370	COG2890	protein-(glutamine-N5) methyltransferase activity
C2E15_RS09380	COG2912	Transglutaminase-like superfamily
C2E15_RS09385	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2E15_RS09390	COG0387	Pfam Sodium calcium exchanger
C2E15_RS09395	COG4572	Cation transport regulator
C2E15_RS09400	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2E15_RS09405	COG0515	serine threonine protein kinase
C2E15_RS09445	COG0840	transmembrane signaling receptor activity
C2E15_RS09450	COG3707	response regulator
C2E15_RS09460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2E15_RS09465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2E15_RS09470	COG1116	anion transmembrane transporter activity
C2E15_RS09475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2E15_RS09475	COG2146	nitrite reductase [NAD(P)H] activity
C2E15_RS09480	COG0243	molybdopterin cofactor binding
C2E15_RS09485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2E15_RS09485	COG1648	precorrin-2 dehydrogenase activity
C2E15_RS09495	COG4932	domain protein
C2E15_RS09505	COG1294	oxidase, subunit
C2E15_RS09510	COG1271	oxidase subunit
C2E15_RS09525	COG1012	belongs to the aldehyde dehydrogenase family
C2E15_RS09530	COG3724	N-succinylarginine dihydrolase activity
C2E15_RS09535	COG2988	succinylglutamate desuccinylase activity
C2E15_RS09540	COG3678	ATP-independent chaperone mediated protein folding
C2E15_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS09550	COG0322	excinuclease ABC activity
C2E15_RS09565	COG2814	Major facilitator Superfamily
C2E15_RS09570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2E15_RS09580	COG0753	catalase activity
C2E15_RS09585	COG1823	symporter activity
C2E15_RS09590	COG1988	membrane-bound metal-dependent
C2E15_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS09605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E15_RS09615	COG3001	Fructosamine kinase
C2E15_RS09630	COG3137	Salt-induced outer membrane protein
C2E15_RS09635	COG1294	oxidase, subunit
C2E15_RS09640	COG1271	oxidase subunit
C2E15_RS09650	COG3383	formate dehydrogenase (NAD+) activity
C2E15_RS09675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2E15_RS09705	COG0776	regulation of translation
C2E15_RS09715	COG4139	cobalamin transport
C2E15_RS09720	COG0386	Belongs to the glutathione peroxidase family
C2E15_RS09730	COG0791	NLP P60 protein
C2E15_RS09735	COG2200	EAL domain
C2E15_RS09740	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2E15_RS09745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2E15_RS09750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2E15_RS09755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2E15_RS09755	COG0574	Belongs to the PEP-utilizing enzyme family
C2E15_RS09765	COG0628	permease
C2E15_RS09770	COG0247	lactate metabolic process
C2E15_RS09770	COG0277	FAD linked oxidase domain protein
C2E15_RS09775	COG2050	protein possibly involved in aromatic compounds catabolism
C2E15_RS09785	COG0316	Belongs to the HesB IscA family
C2E15_RS09790	COG0719	Fe-S assembly protein
C2E15_RS09795	COG0396	ATPase activity
C2E15_RS09800	COG0719	Fe-S assembly protein
C2E15_RS09815	COG1388	LysM domain
C2E15_RS09815	COG1376	ErfK ybiS ycfS ynhG family protein
C2E15_RS09855	COG0307	riboflavin synthase, alpha
C2E15_RS09860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2E15_RS09865	COG2814	Major facilitator Superfamily
C2E15_RS09870	COG0583	DNA-binding transcription factor activity
C2E15_RS09875	COG1609	Transcriptional regulator
C2E15_RS09885	COG0791	NLP P60 protein
C2E15_RS09890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2E15_RS09900	COG0346	lactoylglutathione lyase activity
C2E15_RS09905	COG1309	transcriptional regulator
C2E15_RS09910	COG2194	sulfuric ester hydrolase activity
C2E15_RS09915	COG3313	Fe-S protein
C2E15_RS09920	COG4989	oxidoreductase activity
C2E15_RS09940	COG3133	Outer membrane lipoprotein
C2E15_RS09945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2E15_RS09970	COG0625	glutathione transferase activity
C2E15_RS09975	COG3104	oligopeptide transport
C2E15_RS09980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2E15_RS09985	COG1309	transcriptional regulator
C2E15_RS09995	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2E15_RS10000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2E15_RS10005	COG4660	Part of a membrane complex involved in electron transport
C2E15_RS10010	COG4659	FMN binding
C2E15_RS10020	COG4656	Part of a membrane complex involved in electron transport
C2E15_RS10025	COG2878	Part of a membrane complex involved in electron transport
C2E15_RS10030	COG4657	Part of a membrane complex involved in electron transport
C2E15_RS10045	COG1879	ABC-type sugar transport system periplasmic component
C2E15_RS10050	COG1129	ABC transporter
C2E15_RS10055	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E15_RS10060	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E15_RS10065	COG2160	L-arabinose isomerase activity
C2E15_RS10070	COG1069	ribulokinase activity
C2E15_RS10075	COG1879	ABC-type sugar transport system periplasmic component
C2E15_RS10085	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E15_RS10095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2E15_RS10110	COG1609	Transcriptional regulator
C2E15_RS10115	COG5339	Protein conserved in bacteria
C2E15_RS10120	COG1482	cell wall glycoprotein biosynthetic process
C2E15_RS10135	COG2814	Major facilitator Superfamily
C2E15_RS10140	COG0583	DNA-binding transcription factor activity
C2E15_RS10145	COG1940	carbohydrate kinase activity
C2E15_RS10150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2E15_RS10175	COG0477	Major facilitator Superfamily
C2E15_RS10195	COG4221	oxidoreductase activity
C2E15_RS10200	COG0402	S-adenosylhomocysteine deaminase activity
C2E15_RS10210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2E15_RS10220	COG0339	signal peptide processing
C2E15_RS10250	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2E15_RS10255	COG2140	Oxalate decarboxylase
C2E15_RS10260	COG1464	Belongs to the NlpA lipoprotein family
C2E15_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS10280	COG2814	Major facilitator Superfamily
C2E15_RS10290	COG1940	carbohydrate kinase activity
C2E15_RS10295	COG2814	Major facilitator Superfamily
C2E15_RS10295	COG0477	Major facilitator Superfamily
C2E15_RS10310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2E15_RS10315	COG0814	amino acid
C2E15_RS10320	COG4221	oxidoreductase activity
C2E15_RS10325	COG2207	Transcriptional regulator
C2E15_RS10330	COG1126	abc transporter atp-binding protein
C2E15_RS10335	COG0765	amino acid transport
C2E15_RS10355	COG1473	amidohydrolase
C2E15_RS10365	COG0778	Nitroreductase
C2E15_RS10370	COG2181	nitrate reductase activity
C2E15_RS10375	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2E15_RS10380	COG1140	nitrate reductase beta subunit
C2E15_RS10385	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2E15_RS10390	COG2223	nitrite transmembrane transporter activity
C2E15_RS10395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2E15_RS10410	COG0163	prenyltransferase activity
C2E15_RS10415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2E15_RS10450	COG3634	alkyl hydroperoxide reductase activity
C2E15_RS10465	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2E15_RS10475	COG2382	esterase
C2E15_RS10505	COG1215	transferase activity, transferring glycosyl groups
C2E15_RS10525	COG3437	response regulator, receiver
C2E15_RS10525	COG2205	protein histidine kinase activity
C2E15_RS10525	COG3850	Histidine kinase
C2E15_RS10525	COG4999	Histidine kinase
C2E15_RS10530	COG3250	beta-galactosidase activity
C2E15_RS10555	COG2084	Dehydrogenase
C2E15_RS10565	COG1396	sequence-specific DNA binding
C2E15_RS10570	COG3135	benzoate transporter
C2E15_RS10575	COG3729	General stress protein
C2E15_RS10645	COG0477	Major facilitator Superfamily
C2E15_RS10655	COG2814	Major facilitator Superfamily
C2E15_RS10665	COG0235	Class ii aldolase
C2E15_RS10695	COG1012	belongs to the aldehyde dehydrogenase family
C2E15_RS10700	COG1609	Transcriptional regulator
C2E15_RS10705	COG2723	6-phospho-beta-galactosidase activity
C2E15_RS10710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E15_RS10710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E15_RS10715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E15_RS10720	COG0747	negative chemotaxis
C2E15_RS10725	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2E15_RS10735	COG0436	Aminotransferase
C2E15_RS10740	COG0583	DNA-binding transcription factor activity
C2E15_RS10745	COG0840	transmembrane signaling receptor activity
C2E15_RS10755	COG5383	Protein conserved in bacteria
C2E15_RS10765	COG0583	DNA-binding transcription factor activity
C2E15_RS10770	COG2840	Smr protein MutS2
C2E15_RS10775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2E15_RS10785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2E15_RS10790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2E15_RS10800	COG0531	amino acid
C2E15_RS10810	COG0745	RESPONSE REGULATOR receiver
C2E15_RS10815	COG2205	protein histidine kinase activity
C2E15_RS10820	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2E15_RS10830	COG3591	Belongs to the peptidase S1B family
C2E15_RS10835	COG1643	Atp-dependent helicase
C2E15_RS10840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2E15_RS10845	COG3784	Protein of unknown function (DUF1318)
C2E15_RS10860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E15_RS10870	COG2203	Gaf domain
C2E15_RS10870	COG4251	negative regulation of phosphorylation
C2E15_RS10870	COG5001	Diguanylate cyclase
C2E15_RS10870	COG3706	GGDEF domain
C2E15_RS10895	COG1874	Beta-galactosidase
C2E15_RS10905	COG3833	ABC-type maltose transport systems, permease component
C2E15_RS10910	COG1175	transmembrane transport
C2E15_RS10915	COG2182	Extracellular solute-binding protein
C2E15_RS10940	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS10945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2E15_RS10970	COG0640	Transcriptional regulator
C2E15_RS11000	COG0037	tRNA processing
C2E15_RS11010	COG4166	transmembrane transport
C2E15_RS11015	COG2866	Carboxypeptidase
C2E15_RS11020	COG4948	Mandelate Racemase Muconate Lactonizing
C2E15_RS11025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2E15_RS11055	COG3106	COG3106 Predicted ATPase
C2E15_RS11065	COG1983	PspC domain protein
C2E15_RS11075	COG1842	Phage shock protein A
C2E15_RS11080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2E15_RS11105	COG4172	Belongs to the ABC transporter superfamily
C2E15_RS11115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2E15_RS11120	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2E15_RS11120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2E15_RS11135	COG3772	lysozyme
C2E15_RS11165	COG3182	Iron-regulated membrane protein
C2E15_RS11170	COG2200	EAL domain
C2E15_RS11175	COG0784	Response regulator, receiver
C2E15_RS11175	COG0835	chemotaxis
C2E15_RS11185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS11185	COG1263	PTS System
C2E15_RS11195	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2E15_RS11200	COG1966	Carbon starvation protein
C2E15_RS11210	COG5001	Diguanylate cyclase
C2E15_RS11215	COG1024	Enoyl-CoA hydratase
C2E15_RS11235	COG0023	Translation Initiation Factor
C2E15_RS11245	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2E15_RS11250	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2E15_RS11255	COG0671	phosphoesterase, PA-phosphatase related
C2E15_RS11265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2E15_RS11290	COG0616	signal peptide processing
C2E15_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS11315	COG0009	L-threonylcarbamoyladenylate synthase
C2E15_RS11330	COG0512	Glutamine amidotransferase of anthranilate synthase
C2E15_RS11335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2E15_RS11340	COG0134	indole-3-glycerol-phosphate synthase activity
C2E15_RS11340	COG0135	phosphoribosylanthranilate isomerase activity
C2E15_RS11355	COG2823	Periplasmic or secreted lipoprotein
C2E15_RS11360	COG3047	cAMP biosynthetic process
C2E15_RS11365	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2E15_RS11375	COG2917	probably involved in intracellular septation
C2E15_RS11390	COG2350	Protein conserved in bacteria
C2E15_RS11400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E15_RS11405	COG3099	Belongs to the UPF0263 family
C2E15_RS11410	COG4608	Belongs to the ABC transporter superfamily
C2E15_RS11415	COG0444	Belongs to the ABC transporter superfamily
C2E15_RS11420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E15_RS11440	COG2095	MarC family integral membrane protein
C2E15_RS11445	COG1012	belongs to the aldehyde dehydrogenase family
C2E15_RS11445	COG1454	alcohol dehydrogenase
C2E15_RS11450	COG1435	thymidine kinase activity
C2E15_RS11470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2E15_RS11475	COG0745	RESPONSE REGULATOR receiver
C2E15_RS11480	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2E15_RS11485	COG3012	SEC-C Motif Domain Protein
C2E15_RS11490	COG0788	formyltetrahydrofolate deformylase activity
C2E15_RS11505	COG0708	Exodeoxyribonuclease III
C2E15_RS11515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2E15_RS11525	COG0778	Nitroreductase
C2E15_RS11530	COG0616	signal peptide processing
C2E15_RS11535	COG0252	asparaginase activity
C2E15_RS11540	COG1335	isochorismatase
C2E15_RS11545	COG3139	Protein of unknown function (DUF1315)
C2E15_RS11550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2E15_RS11570	COG0656	L-ascorbic acid biosynthetic process
C2E15_RS11575	COG3713	MltA-interacting MipA family protein
C2E15_RS11580	COG2766	serine protein kinase
C2E15_RS11630	COG0484	heat shock protein binding
C2E15_RS11635	COG1403	HNH endonuclease
C2E15_RS11715	COG0582	viral genome integration into host DNA
C2E15_RS11740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2E15_RS11745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2E15_RS11750	COG2719	SpoVR family
C2E15_RS11755	COG2186	Transcriptional regulator
C2E15_RS11775	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2E15_RS11780	COG2951	lytic endotransglycosylase activity
C2E15_RS11790	COG0850	regulation of cytokinetic process
C2E15_RS11795	COG2894	cell division
C2E15_RS11800	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2E15_RS11810	COG0318	PFAM AMP-dependent synthetase and ligase
C2E15_RS11815	COG3065	identical protein binding
C2E15_RS11820	COG1214	PFAM Peptidase M22, glycoprotease
C2E15_RS11825	COG1199	ATP-dependent helicase activity
C2E15_RS11830	COG0251	oxidation-reduction process
C2E15_RS11835	COG3140	Belongs to the UPF0181 family
C2E15_RS11850	COG1760	l-serine dehydratase
C2E15_RS11855	COG2200	EAL domain
C2E15_RS11860	COG1253	flavin adenine dinucleotide binding
C2E15_RS11865	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS11865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS11870	COG3715	PTS system
C2E15_RS11885	COG1971	Probably functions as a manganese efflux pump
C2E15_RS11890	COG2226	methyltransferase
C2E15_RS11925	COG2814	Major facilitator Superfamily
C2E15_RS11930	COG0501	Belongs to the peptidase M48B family
C2E15_RS11940	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2E15_RS11945	COG1956	GAF domain-containing protein
C2E15_RS11950	COG2995	paraquat-inducible protein a
C2E15_RS11955	COG3008	intermembrane lipid transfer
C2E15_RS11975	COG0710	3-dehydroquinate dehydratase activity
C2E15_RS12115	COG4974	Belongs to the 'phage' integrase family
C2E15_RS12130	COG2372	response to copper ion
C2E15_RS12140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2E15_RS12145	COG1770	oligopeptidase
C2E15_RS12150	COG2979	Protein of unknown function (DUF533)
C2E15_RS12155	COG3141	response to X-ray
C2E15_RS12160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2E15_RS12165	COG0800	Aldolase
C2E15_RS12170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2E15_RS12175	COG1737	Transcriptional regulator
C2E15_RS12180	COG0469	pyruvate kinase activity
C2E15_RS12185	COG0076	glutamate decarboxylase activity
C2E15_RS12190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C2E15_RS12205	COG1560	Kdo2-lipid A biosynthetic process
C2E15_RS12210	COG0739	heme binding
C2E15_RS12215	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2E15_RS12225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2E15_RS12230	COG2255	four-way junction helicase activity
C2E15_RS12235	COG0632	four-way junction helicase activity
C2E15_RS12250	COG0494	nUDIX hydrolase
C2E15_RS12260	COG1335	isochorismatase
C2E15_RS12265	COG1801	Protein of unknown function DUF72
C2E15_RS12270	COG2226	methyltransferase
C2E15_RS12275	COG0500	methyltransferase
C2E15_RS12280	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS12360	COG0840	transmembrane signaling receptor activity
C2E15_RS12380	COG0673	inositol 2-dehydrogenase activity
C2E15_RS12385	COG2814	Major facilitator Superfamily
C2E15_RS12385	COG0477	Major facilitator Superfamily
C2E15_RS12395	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS12410	COG3142	Participates in the control of copper homeostasis
C2E15_RS12415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2E15_RS12420	COG3102	Protein conserved in bacteria
C2E15_RS12425	COG0018	arginyl-trna synthetase
C2E15_RS12455	COG0745	RESPONSE REGULATOR receiver
C2E15_RS12465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2E15_RS12470	COG0840	transmembrane signaling receptor activity
C2E15_RS12485	COG0835	chemotaxis
C2E15_RS12520	COG1877	trehalose-phosphatase activity
C2E15_RS12525	COG2135	peptidase activity
C2E15_RS12535	COG0583	DNA-binding transcription factor activity
C2E15_RS12540	COG2814	Major facilitator Superfamily
C2E15_RS12550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2E15_RS12565	COG1702	phosphate starvation-inducible protein PhoH
C2E15_RS12575	COG2822	iron ion transport
C2E15_RS12590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2E15_RS12600	COG1522	sequence-specific DNA binding
C2E15_RS12620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2E15_RS12635	COG2423	ornithine cyclodeaminase activity
C2E15_RS12640	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS12650	COG1473	amidohydrolase
C2E15_RS12660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2E15_RS12670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E15_RS12700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2E15_RS12710	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2E15_RS12710	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2E15_RS12710	COG0506	proline dehydrogenase activity
C2E15_RS12720	COG1126	abc transporter atp-binding protein
C2E15_RS12725	COG0765	amino acid transport
C2E15_RS12730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E15_RS12770	COG1216	Glycosyl transferase, family 2
C2E15_RS12770	COG0438	transferase activity, transferring glycosyl groups
C2E15_RS12825	COG1278	Cold shock
C2E15_RS12840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2E15_RS12840	COG2755	lipolytic protein G-D-S-L family
C2E15_RS12850	COG2246	polysaccharide biosynthetic process
C2E15_RS12890	COG1677	Flagellar hook-basal body complex protein FliE
C2E15_RS12900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2E15_RS12925	COG1580	Controls the rotational direction of flagella during chemotaxis
C2E15_RS12945	COG1338	Plays a role in the flagellum-specific transport system
C2E15_RS12965	COG0840	transmembrane signaling receptor activity
C2E15_RS12995	COG1215	transferase activity, transferring glycosyl groups
C2E15_RS13015	COG5475	Uncharacterized small protein (DUF2158)
C2E15_RS13020	COG2354	Protein conserved in bacteria
C2E15_RS13030	COG0697	spore germination
C2E15_RS13035	COG3727	T/G mismatch-specific endonuclease activity
C2E15_RS13040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2E15_RS13060	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2E15_RS13075	COG1418	mRNA catabolic process
C2E15_RS13085	COG3228	Belongs to the MtfA family
C2E15_RS13110	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS13125	COG0583	DNA-binding transcription factor activity
C2E15_RS13135	COG0534	Mate efflux family protein
C2E15_RS13145	COG3119	arylsulfatase activity
C2E15_RS13160	COG2080	2 iron, 2 sulfur cluster binding
C2E15_RS13165	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2E15_RS13170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2E15_RS13180	COG2076	Multidrug Resistance protein
C2E15_RS13185	COG2076	Multidrug Resistance protein
C2E15_RS13190	COG2252	PERMEase
C2E15_RS13195	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2E15_RS13200	COG2188	Transcriptional regulator
C2E15_RS13205	COG3300	MHYT domain
C2E15_RS13205	COG5001	Diguanylate cyclase
C2E15_RS13210	COG0300	oxidoreductase activity
C2E15_RS13215	COG0028	Belongs to the TPP enzyme family
C2E15_RS13235	COG2851	Citrate transporter
C2E15_RS13240	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E15_RS13245	COG1129	ABC transporter
C2E15_RS13270	COG1864	DNA RNA non-specific endonuclease
C2E15_RS13270	COG3591	Belongs to the peptidase S1B family
C2E15_RS13285	COG1289	transmembrane transporter activity
C2E15_RS13305	COG0243	molybdopterin cofactor binding
C2E15_RS13315	COG2925	Exonuclease
C2E15_RS13325	COG0531	amino acid
C2E15_RS13335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2E15_RS13340	COG0174	glutamine synthetase
C2E15_RS13345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2E15_RS13350	COG1917	Cupin 2, conserved barrel domain protein
C2E15_RS13350	COG1396	sequence-specific DNA binding
C2E15_RS13355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2E15_RS13360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2E15_RS13370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2E15_RS13395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2E15_RS13405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2E15_RS13405	COG0140	phosphoribosyl-ATP diphosphatase activity
C2E15_RS13410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2E15_RS13440	COG1086	Polysaccharide biosynthesis protein
C2E15_RS13470	COG0438	transferase activity, transferring glycosyl groups
C2E15_RS13480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2E15_RS13485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2E15_RS13505	COG2244	polysaccharide biosynthetic process
C2E15_RS13510	COG2327	Polysaccharide pyruvyl transferase
C2E15_RS13515	COG1216	Glycosyl transferase, family 2
C2E15_RS13515	COG1442	glycosyl transferase family 8
C2E15_RS13545	COG0463	Glycosyl transferase, family 2
C2E15_RS13550	COG3206	protein involved in exopolysaccharide biosynthesis
C2E15_RS13550	COG0489	protein tyrosine kinase activity
C2E15_RS13555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2E15_RS13560	COG1596	polysaccharide export
C2E15_RS13565	COG1253	flavin adenine dinucleotide binding
C2E15_RS13570	COG2982	Protein involved in outer membrane biogenesis
C2E15_RS13575	COG0717	Belongs to the dCTP deaminase family
C2E15_RS13580	COG0572	uridine kinase
C2E15_RS13590	COG5001	Diguanylate cyclase
C2E15_RS13590	COG3447	MASE1 domain protein
C2E15_RS13590	COG5002	protein histidine kinase activity
C2E15_RS13595	COG0443	Heat shock 70 kDa protein
C2E15_RS13650	COG4964	Belongs to the GSP D family
C2E15_RS13680	COG0667	Aldo Keto reductase
C2E15_RS13685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2E15_RS13705	COG2205	protein histidine kinase activity
C2E15_RS13710	COG0745	RESPONSE REGULATOR receiver
C2E15_RS13715	COG0826	peptidase U32
C2E15_RS13720	COG1597	lipid kinase activity
C2E15_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
C2E15_RS13730	COG1063	alcohol dehydrogenase
C2E15_RS13735	COG2271	Major facilitator Superfamily
C2E15_RS13740	COG0246	Mannitol dehydrogenase
C2E15_RS13745	COG1802	Transcriptional regulator
C2E15_RS13795	COG2951	lytic endotransglycosylase activity
C2E15_RS13805	COG4574	serine-type endopeptidase inhibitor activity
C2E15_RS13810	COG2814	Major facilitator Superfamily
C2E15_RS13820	COG3005	denitrification pathway
C2E15_RS13835	COG1454	alcohol dehydrogenase
C2E15_RS13845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E15_RS13845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E15_RS13850	COG1380	Effector of murein hydrolase LrgA
C2E15_RS13855	COG1346	cytolysis
C2E15_RS13860	COG0295	cytidine deaminase activity
C2E15_RS13865	COG0281	malic enzyme
C2E15_RS13870	COG2949	membrane
C2E15_RS13880	COG1129	ABC transporter
C2E15_RS13890	COG1609	Transcriptional regulator
C2E15_RS13895	COG2311	Membrane
C2E15_RS13905	COG0477	Major facilitator Superfamily
C2E15_RS13910	COG0583	DNA-binding transcription factor activity
C2E15_RS13925	COG4771	TonB-dependent receptor
C2E15_RS13930	COG1120	ATPase activity
C2E15_RS13940	COG0833	amino acid
C2E15_RS13945	COG0583	DNA-binding transcription factor activity
C2E15_RS13955	COG2855	membrane
C2E15_RS13960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2E15_RS13970	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2E15_RS13970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E15_RS13970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E15_RS13975	COG1105	Belongs to the carbohydrate kinase PfkB family
C2E15_RS13980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS13980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS13990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2E15_RS14000	COG0523	cobalamin synthesis protein
C2E15_RS14005	COG0671	phosphoesterase, PA-phosphatase related
C2E15_RS14010	COG0791	NLP P60 protein
C2E15_RS14015	COG2200	EAL domain
C2E15_RS14020	COG4166	transmembrane transport
C2E15_RS14025	COG4174	ABC transporter (Permease)
C2E15_RS14030	COG4239	(ABC) transporter, permease
C2E15_RS14035	COG4172	Belongs to the ABC transporter superfamily
C2E15_RS14045	COG2814	Major facilitator Superfamily
C2E15_RS14050	COG1187	pseudouridine synthase activity
C2E15_RS14055	COG1061	Type III restriction enzyme res subunit
C2E15_RS14060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2E15_RS14070	COG3082	Protein of unknown function (DUF1414)
C2E15_RS14105	COG0789	Transcriptional regulator
C2E15_RS14110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2E15_RS14115	COG0697	spore germination
C2E15_RS14120	COG1309	transcriptional regulator
C2E15_RS14125	COG0583	DNA-binding transcription factor activity
C2E15_RS14160	COG5654	RES domain protein
C2E15_RS14165	COG5642	Protein of unknown function (DUF2384)
C2E15_RS14180	COG4615	Cyclic peptide transporter
C2E15_RS14210	COG1132	(ABC) transporter
C2E15_RS14240	COG2223	nitrite transmembrane transporter activity
C2E15_RS14245	COG2198	Histidine kinase
C2E15_RS14245	COG0642	Histidine kinase
C2E15_RS14255	COG0784	Response regulator, receiver
C2E15_RS14255	COG2205	protein histidine kinase activity
C2E15_RS14265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2E15_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS14290	COG0583	DNA-binding transcription factor activity
C2E15_RS14295	COG2271	Major facilitator Superfamily
C2E15_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS14305	COG3959	Transketolase, thiamine diphosphate binding domain
C2E15_RS14310	COG3958	Transketolase
C2E15_RS14325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E15_RS14330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E15_RS14335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2E15_RS14355	COG1441	menaquinone biosynthetic process
C2E15_RS14360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2E15_RS14370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2E15_RS14375	COG1169	isochorismate synthase
C2E15_RS14380	COG4575	ribosome binding
C2E15_RS14390	COG0431	NADPH-dependent FMN reductase
C2E15_RS14395	COG2153	protein acetylation
C2E15_RS14400	COG1007	ATP synthesis coupled electron transport
C2E15_RS14405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2E15_RS14410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2E15_RS14415	COG0713	ATP synthesis coupled electron transport
C2E15_RS14420	COG0839	Belongs to the complex I subunit 6 family
C2E15_RS14450	COG0649	NAD binding
C2E15_RS14450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2E15_RS14460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2E15_RS14470	COG0583	DNA-binding transcription factor activity
C2E15_RS14475	COG0436	Aminotransferase
C2E15_RS14480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2E15_RS14485	COG0471	metal ion transport
C2E15_RS14485	COG0490	domain, Protein
C2E15_RS14490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E15_RS14495	COG3013	Belongs to the UPF0304 family
C2E15_RS14500	COG3092	negative regulation of chromosome organization
C2E15_RS14505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2E15_RS14510	COG0280	phosphate acetyltransferase
C2E15_RS14510	COG0857	belongs to the CobB CobQ family
C2E15_RS14520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2E15_RS14525	COG3959	Transketolase, thiamine diphosphate binding domain
C2E15_RS14540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS14545	COG1609	Transcriptional regulator
C2E15_RS14555	COG0625	glutathione transferase activity
C2E15_RS14560	COG1090	epimerase
C2E15_RS14565	COG4598	ABC transporter
C2E15_RS14570	COG4160	amino acid transport
C2E15_RS14585	COG0163	prenyltransferase activity
C2E15_RS14590	COG0583	DNA-binding transcription factor activity
C2E15_RS14595	COG0667	Aldo Keto reductase
C2E15_RS14605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2E15_RS14610	COG1286	toxin biosynthetic process
C2E15_RS14615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2E15_RS14620	COG0285	dihydrofolate synthase activity
C2E15_RS14630	COG0586	Pfam SNARE associated Golgi protein
C2E15_RS14640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2E15_RS14680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2E15_RS14695	COG3101	peptidyl-lysine hydroxylation
C2E15_RS14700	COG0730	response to heat
C2E15_RS14710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2E15_RS14725	COG2062	phosphohistidine phosphatase, SixA
C2E15_RS14730	COG1024	Enoyl-CoA hydratase
C2E15_RS14730	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2E15_RS14735	COG0183	Belongs to the thiolase family
C2E15_RS14740	COG3691	Protein conserved in bacteria
C2E15_RS14745	COG2067	long-chain fatty acid transport protein
C2E15_RS14760	COG4235	cytochrome complex assembly
C2E15_RS14760	COG3088	subunit of a heme lyase
C2E15_RS14770	COG1138	Cytochrome C-type biogenesis protein
C2E15_RS14780	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2E15_RS14785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2E15_RS14790	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2E15_RS14800	COG2116	formate transmembrane transporter activity
C2E15_RS14810	COG0582	viral genome integration into host DNA
C2E15_RS14940	COG1783	phage Terminase large subunit
C2E15_RS14970	COG3179	chitinase
C2E15_RS15045	COG0305	Participates in initiation and elongation during chromosome replication
C2E15_RS15090	COG3645	SOS response
C2E15_RS15090	COG3646	Phage regulatory protein
C2E15_RS15190	COG3122	Protein conserved in bacteria
C2E15_RS15205	COG0840	transmembrane signaling receptor activity
C2E15_RS15220	COG2223	nitrite transmembrane transporter activity
C2E15_RS15230	COG2723	6-phospho-beta-galactosidase activity
C2E15_RS15280	COG0436	Aminotransferase
C2E15_RS15285	COG3275	phosphorelay sensor kinase activity
C2E15_RS15290	COG3279	Response regulator of the LytR AlgR family
C2E15_RS15295	COG0837	glucose binding
C2E15_RS15300	COG3961	Belongs to the TPP enzyme family
C2E15_RS15305	COG0667	Aldo Keto reductase
C2E15_RS15315	COG1914	H( )-stimulated, divalent metal cation uptake system
C2E15_RS15320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2E15_RS15335	COG2116	formate transmembrane transporter activity
C2E15_RS15340	COG3415	Transposase
C2E15_RS15345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2E15_RS15380	COG0583	DNA-binding transcription factor activity
C2E15_RS15385	COG0385	Bile acid
C2E15_RS15390	COG3530	Putative quorum-sensing-regulated virulence factor
C2E15_RS15400	COG3115	cell septum assembly
C2E15_RS15425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2E15_RS15435	COG2205	protein histidine kinase activity
C2E15_RS15440	COG0745	RESPONSE REGULATOR receiver
C2E15_RS15445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2E15_RS15450	COG1136	(ABC) transporter
C2E15_RS15450	COG0577	efflux transmembrane transporter activity
C2E15_RS15460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2E15_RS15465	COG4208	sulfate ABC transporter
C2E15_RS15470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2E15_RS15480	COG2837	iron assimilation
C2E15_RS15495	COG0456	acetyltransferase
C2E15_RS15500	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2E15_RS15505	COG0408	coproporphyrinogen oxidase activity
C2E15_RS15510	COG0280	phosphate acetyltransferase
C2E15_RS15510	COG0281	malic enzyme
C2E15_RS15515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2E15_RS15520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2E15_RS15540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2E15_RS15545	COG5342	invasion associated locus B
C2E15_RS15550	COG1349	DNA-binding transcription factor activity
C2E15_RS15560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E15_RS15565	COG0494	nUDIX hydrolase
C2E15_RS15570	COG2181	nitrate reductase activity
C2E15_RS15575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2E15_RS15580	COG1140	nitrate reductase beta subunit
C2E15_RS15585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2E15_RS15590	COG2223	nitrite transmembrane transporter activity
C2E15_RS15595	COG2197	response regulator
C2E15_RS15605	COG3850	Histidine kinase
C2E15_RS15610	COG2197	response regulator
C2E15_RS15615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2E15_RS15620	COG1393	Belongs to the ArsC family
C2E15_RS15625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2E15_RS15635	COG0400	carboxylic ester hydrolase activity
C2E15_RS15640	COG1444	tRNA N-acetyltransferase activity
C2E15_RS15645	COG2321	neutral zinc metallopeptidase
C2E15_RS15655	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2E15_RS15660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2E15_RS15665	COG2716	regulation of RNA biosynthetic process
C2E15_RS15670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2E15_RS15695	COG4783	chaperone-mediated protein folding
C2E15_RS15700	COG1393	Belongs to the ArsC family
C2E15_RS15725	COG2233	PERMEase
C2E15_RS15735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2E15_RS15740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2E15_RS15745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2E15_RS15755	COG0573	inorganic phosphate transmembrane transporter activity
C2E15_RS15765	COG0248	Ppx GppA phosphatase
C2E15_RS15770	COG0500	methyltransferase
C2E15_RS15775	COG2200	EAL domain
C2E15_RS15785	COG2239	Acts as a magnesium transporter
C2E15_RS15810	COG0596	Alpha beta hydrolase
C2E15_RS15820	COG0516	GMP reductase activity
C2E15_RS15820	COG0517	IMP dehydrogenase activity
C2E15_RS15825	COG1570	exodeoxyribonuclease VII activity
C2E15_RS15835	COG2271	Major facilitator Superfamily
C2E15_RS15840	COG1609	Transcriptional regulator
C2E15_RS15855	COG4993	Dehydrogenase
C2E15_RS15860	COG1645	bacterial-type flagellum-dependent swarming motility
C2E15_RS15865	COG1160	GTP binding
C2E15_RS15870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2E15_RS15875	COG2976	Protein conserved in bacteria
C2E15_RS15880	COG0124	histidyl-tRNA synthetase
C2E15_RS15890	COG1426	Protein conserved in bacteria
C2E15_RS15900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2E15_RS15905	COG0105	UTP biosynthetic process
C2E15_RS15910	COG4953	penicillin-binding protein 1C
C2E15_RS15915	COG2373	Large extracellular alpha-helical protein
C2E15_RS15920	COG2897	thiosulfate sulfurtransferase activity
C2E15_RS15930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2E15_RS15935	COG2975	iron-sulfur cluster assembly
C2E15_RS15940	COG0633	Ferredoxin
C2E15_RS15950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2E15_RS15960	COG0822	iron-sulfur transferase activity
C2E15_RS15970	COG1959	2 iron, 2 sulfur cluster binding
C2E15_RS15980	COG0483	inositol monophosphate 1-phosphatase activity
C2E15_RS15985	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2E15_RS15990	COG3683	transport system, periplasmic component
C2E15_RS15995	COG3711	transcriptional antiterminator
C2E15_RS16000	COG2814	Major facilitator Superfamily
C2E15_RS16005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2E15_RS16010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2E15_RS16010	COG1017	nitric oxide dioxygenase activity
C2E15_RS16015	COG1794	racemase activity, acting on amino acids and derivatives
C2E15_RS16020	COG0347	Belongs to the P(II) protein family
C2E15_RS16025	COG2204	response regulator
C2E15_RS16030	COG3170	Tfp pilus assembly protein FimV
C2E15_RS16035	COG2205	protein histidine kinase activity
C2E15_RS16040	COG0047	phosphoribosylformylglycinamidine synthase activity
C2E15_RS16040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2E15_RS16045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2E15_RS16055	COG0560	Phosphoserine phosphatase
C2E15_RS16060	COG1737	Transcriptional regulator
C2E15_RS16065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2E15_RS16070	COG0736	holo-[acyl-carrier-protein] synthase activity
C2E15_RS16075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2E15_RS16080	COG1381	Involved in DNA repair and RecF pathway recombination
C2E15_RS16085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2E15_RS16090	COG0571	ribonuclease III activity
C2E15_RS16100	COG0481	GTPase activity
C2E15_RS16105	COG3086	response to oxidative stress
C2E15_RS16110	COG3026	antisigma factor binding
C2E15_RS16130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2E15_RS16140	COG0513	Belongs to the DEAD box helicase family
C2E15_RS16145	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
C2E15_RS16150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2E15_RS16155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2E15_RS16165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2E15_RS16170	COG0497	DNA recombination
C2E15_RS16175	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2E15_RS16180	COG2914	Belongs to the UPF0125 (RnfH) family
C2E15_RS16185	COG2867	negative regulation of translational initiation
C2E15_RS16260	COG2807	transmembrane transport
C2E15_RS16270	COG2076	Multidrug Resistance protein
C2E15_RS16290	COG1966	Carbon starvation protein
C2E15_RS16305	COG4566	intracellular signal transduction
C2E15_RS16345	COG1741	Belongs to the pirin family
C2E15_RS16350	COG0583	DNA-binding transcription factor activity
C2E15_RS16360	COG0494	nUDIX hydrolase
C2E15_RS16365	COG1349	DNA-binding transcription factor activity
C2E15_RS16375	COG4773	Receptor
C2E15_RS16380	COG4807	Protein conserved in bacteria
C2E15_RS16385	COG3279	Response regulator of the LytR AlgR family
C2E15_RS16390	COG3275	phosphorelay sensor kinase activity
C2E15_RS16395	COG1764	response to oxidative stress
C2E15_RS16405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2E15_RS16415	COG2040	homocysteine
C2E15_RS16420	COG0833	amino acid
C2E15_RS16430	COG4575	ribosome binding
C2E15_RS16440	COG1780	Probably involved in ribonucleotide reductase function
C2E15_RS16445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E15_RS16450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E15_RS16455	COG4175	Glycine betaine
C2E15_RS16470	COG2814	Major facilitator Superfamily
C2E15_RS16475	COG1846	Transcriptional regulator
C2E15_RS16480	COG1566	PFAM secretion protein HlyD family protein
C2E15_RS16485	COG2814	Major facilitator Superfamily
C2E15_RS16490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2E15_RS16495	COG3118	belongs to the thioredoxin family
C2E15_RS16500	COG3148	PFAM DTW domain containing protein
C2E15_RS16505	COG1042	CoA-binding domain protein
C2E15_RS16505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2E15_RS16505	COG0045	succinate-CoA ligase (ADP-forming) activity
C2E15_RS16510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E15_RS16515	COG5544	Lipoprotein
C2E15_RS16520	COG0477	Major facilitator Superfamily
C2E15_RS16555	COG0542	response to heat
C2E15_RS16560	COG1496	oxidoreductase activity
C2E15_RS16565	COG0564	pseudouridine synthase activity
C2E15_RS16570	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2E15_RS16575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2E15_RS16580	COG1605	Chorismate mutase
C2E15_RS16580	COG0077	Prephenate dehydratase
C2E15_RS16585	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS16590	COG0287	Prephenate dehydrogenase
C2E15_RS16590	COG1605	Chorismate mutase
C2E15_RS16595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2E15_RS16620	COG0228	four-way junction DNA binding
C2E15_RS16625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2E15_RS16630	COG4137	Cytochrome C assembly protein
C2E15_RS16635	COG4536	flavin adenine dinucleotide binding
C2E15_RS16650	COG2918	glutathione biosynthetic process
C2E15_RS16655	COG1238	metal cluster binding
C2E15_RS16660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E15_RS16685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2E15_RS16700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2E15_RS16705	COG1546	Belongs to the CinA family
C2E15_RS16710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2E15_RS16715	COG2824	Alkylphosphonate utilization operon protein PhnA
C2E15_RS16720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2E15_RS16725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2E15_RS16730	COG1388	LysM domain
C2E15_RS16730	COG4942	peptidase
C2E15_RS16745	COG0585	pseudouridine synthase activity
C2E15_RS16755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2E15_RS16760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2E15_RS16775	COG2895	sulfate adenylyltransferase (ATP) activity
C2E15_RS16785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2E15_RS16785	COG1648	precorrin-2 dehydrogenase activity
C2E15_RS16790	COG2234	aminopeptidase activity
C2E15_RS16800	COG0330	HflC and HflK could
C2E15_RS16805	COG0175	sulfate reduction
C2E15_RS16810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2E15_RS16820	COG0720	synthase
C2E15_RS16825	COG0602	queuosine metabolic process
C2E15_RS16840	COG0504	CTP synthase activity
C2E15_RS16845	COG3956	TIGRFAM MazG family protein
C2E15_RS16850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2E15_RS16855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2E15_RS16865	COG1929	Belongs to the glycerate kinase type-1 family
C2E15_RS16870	COG2084	Dehydrogenase
C2E15_RS16880	COG4948	Mandelate Racemase Muconate Lactonizing
C2E15_RS16885	COG4948	Mandelate Racemase Muconate Lactonizing
C2E15_RS16890	COG2271	Major facilitator Superfamily
C2E15_RS16895	COG2721	sulfolactate sulfo-lyase activity
C2E15_RS16900	COG0716	FMN binding
C2E15_RS16905	COG0564	pseudouridine synthase activity
C2E15_RS16910	COG3098	single-species biofilm formation
C2E15_RS16920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2E15_RS16920	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2E15_RS16925	COG1611	Belongs to the LOG family
C2E15_RS16935	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2E15_RS16940	COG2363	Small membrane protein
C2E15_RS16945	COG0583	DNA-binding transcription factor activity
C2E15_RS16955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2E15_RS16960	COG2166	iron-sulfur cluster assembly
C2E15_RS16965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2E15_RS16970	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2E15_RS16985	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2E15_RS16990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2E15_RS16990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2E15_RS16995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2E15_RS17005	COG1025	Belongs to the peptidase M16 family
C2E15_RS17010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2E15_RS17025	COG4795	General secretion pathway protein
C2E15_RS17035	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C2E15_RS17045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2E15_RS17055	COG1051	belongs to the nudix hydrolase family
C2E15_RS17070	COG3066	DNA modification
C2E15_RS17075	COG0861	Integral membrane protein TerC family
C2E15_RS17085	COG0667	Aldo Keto reductase
C2E15_RS17095	COG0318	PFAM AMP-dependent synthetase and ligase
C2E15_RS17095	COG0204	Acyl-transferase
C2E15_RS17100	COG0768	penicillin binding
C2E15_RS17110	COG1609	Transcriptional regulator
C2E15_RS17120	COG2186	Transcriptional regulator
C2E15_RS17125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E15_RS17130	COG2723	6-phospho-beta-galactosidase activity
C2E15_RS17135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E15_RS17140	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2E15_RS17150	COG0583	DNA-binding transcription factor activity
C2E15_RS17155	COG2814	Major facilitator Superfamily
C2E15_RS17170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2E15_RS17180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2E15_RS17185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2E15_RS17190	COG4974	Belongs to the 'phage' integrase family
C2E15_RS17195	COG0716	FMN binding
C2E15_RS17205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2E15_RS17210	COG0354	folic acid binding
C2E15_RS17215	COG1272	protein, Hemolysin III
C2E15_RS17225	COG2723	6-phospho-beta-galactosidase activity
C2E15_RS17235	COG0509	glycine decarboxylation via glycine cleavage system
C2E15_RS17245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2E15_RS17250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2E15_RS17255	COG0006	proline dipeptidase activity
C2E15_RS17260	COG3079	Belongs to the UPF0149 family
C2E15_RS17265	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2E15_RS17275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2E15_RS17280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2E15_RS17285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2E15_RS17290	COG0583	DNA-binding transcription factor activity
C2E15_RS17295	COG2968	Membrane
C2E15_RS17305	COG0668	transmembrane transport
C2E15_RS17310	COG0191	fructose-bisphosphate aldolase activity
C2E15_RS17315	COG0126	phosphoglycerate kinase activity
C2E15_RS17320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2E15_RS17330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2E15_RS17335	COG0501	Belongs to the peptidase M48B family
C2E15_RS17345	COG1166	arginine decarboxylase activity
C2E15_RS17360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2E15_RS17365	COG2814	Major facilitator Superfamily
C2E15_RS17370	COG3091	SprT-like family
C2E15_RS17375	COG2356	endonuclease I
C2E15_RS17390	COG1678	Uncharacterized ACR, COG1678
C2E15_RS17395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2E15_RS17400	COG2805	Type II/IV secretion system protein
C2E15_RS17405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2E15_RS17410	COG0762	integral membrane protein
C2E15_RS17420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2E15_RS17440	COG3171	Protein conserved in bacteria
C2E15_RS17450	COG1194	a g-specific adenine glycosylase
C2E15_RS17460	COG0741	lytic transglycosylase activity
C2E15_RS17465	COG3210	domain, Protein
C2E15_RS17470	COG2831	hemolysin activation secretion protein
C2E15_RS17475	COG5564	TIM-barrel signal transduction protein
C2E15_RS17480	COG5441	Belongs to the UPF0261 family
C2E15_RS17490	COG3916	Acyl-homoserine-lactone synthase
C2E15_RS17505	COG1902	pentaerythritol trinitrate reductase activity
C2E15_RS17520	COG2375	cellular response to nickel ion
C2E15_RS17525	COG1695	Transcriptional regulator
C2E15_RS17530	COG1902	pentaerythritol trinitrate reductase activity
C2E15_RS17535	COG2814	Major facilitator Superfamily
C2E15_RS17565	COG0811	peptide transport
C2E15_RS17580	COG1473	amidohydrolase
C2E15_RS17585	COG0625	glutathione transferase activity
C2E15_RS17605	COG1403	HNH endonuclease
C2E15_RS17625	COG1528	Iron-storage protein
C2E15_RS17630	COG5001	Diguanylate cyclase
C2E15_RS17640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2E15_RS17680	COG2197	response regulator
C2E15_RS17685	COG4297	protein containing double-stranded beta helix domain
C2E15_RS17695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2E15_RS17735	COG1028	Short-chain dehydrogenase reductase Sdr
C2E15_RS17740	COG0848	biopolymer transport protein
C2E15_RS17750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2E15_RS17765	COG0626	cystathionine gamma-synthase activity
C2E15_RS17775	COG2207	Transcriptional regulator
C2E15_RS17780	COG0656	L-ascorbic acid biosynthetic process
C2E15_RS17785	COG2132	Multicopper oxidase
C2E15_RS17795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2E15_RS17805	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2E15_RS17810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2E15_RS17820	COG3150	esterase
C2E15_RS17825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2E15_RS17830	COG3151	Protein conserved in bacteria
C2E15_RS17835	COG0494	nUDIX hydrolase
C2E15_RS17850	COG0754	glutathionylspermidine amidase activity
C2E15_RS17855	COG3384	dioxygenase
C2E15_RS17870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2E15_RS17890	COG3025	triphosphatase activity
C2E15_RS17895	COG4991	sh3 domain protein
C2E15_RS17905	COG1968	undecaprenyl-diphosphatase activity
C2E15_RS17910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2E15_RS17915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2E15_RS17925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2E15_RS17930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2E15_RS17935	COG0358	DNA primase activity
C2E15_RS18010	COG0732	type I restriction modification DNA specificity domain
C2E15_RS18025	COG0582	viral genome integration into host DNA
C2E15_RS18075	COG4695	Portal protein
C2E15_RS18135	COG4974	Belongs to the 'phage' integrase family
C2E15_RS18190	COG1942	4-Oxalocrotonate Tautomerase
C2E15_RS18195	COG0697	spore germination
C2E15_RS18210	COG0583	DNA-binding transcription factor activity
C2E15_RS18215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E15_RS18220	COG2271	Major facilitator Superfamily
C2E15_RS18235	COG2199	diguanylate cyclase activity
C2E15_RS18240	COG0659	secondary active sulfate transmembrane transporter activity
C2E15_RS18245	COG0288	reversible hydration of carbon dioxide
C2E15_RS18250	COG1496	oxidoreductase activity
C2E15_RS18255	COG2197	response regulator
C2E15_RS18270	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2E15_RS18270	COG1902	pentaerythritol trinitrate reductase activity
C2E15_RS18275	COG2813	Specifically methylates the guanine in position
C2E15_RS18280	COG1451	nucleotide metabolic process
C2E15_RS18290	COG0673	inositol 2-dehydrogenase activity
C2E15_RS18300	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2E15_RS18305	COG2721	sulfolactate sulfo-lyase activity
C2E15_RS18310	COG0246	Mannitol dehydrogenase
C2E15_RS18320	COG2271	Major facilitator Superfamily
C2E15_RS18325	COG2186	Transcriptional regulator
C2E15_RS18330	COG0586	Pfam SNARE associated Golgi protein
C2E15_RS18340	COG1422	Protein of unknown function (DUF1090)
C2E15_RS18345	COG4575	ribosome binding
C2E15_RS18350	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2E15_RS18360	COG2259	Doxx family
C2E15_RS18365	COG0435	Glutathione S-transferase
C2E15_RS18370	COG0583	DNA-binding transcription factor activity
C2E15_RS18375	COG1741	Belongs to the pirin family
C2E15_RS18380	COG2823	Periplasmic or secreted lipoprotein
C2E15_RS18385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2E15_RS18390	COG0792	nuclease activity
C2E15_RS18395	COG3107	peptidoglycan biosynthetic process
C2E15_RS18400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2E15_RS18410	COG3711	transcriptional antiterminator
C2E15_RS18410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E15_RS18430	COG3964	amidohydrolase
C2E15_RS18460	COG0312	modulator of DNA gyrase
C2E15_RS18465	COG3028	Belongs to the UPF0307 family
C2E15_RS18470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2E15_RS18475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2E15_RS18480	COG2707	UPF0756 membrane protein
C2E15_RS18490	COG2105	PFAM AIG2 family protein
C2E15_RS18495	COG2911	Protein conserved in bacteria
C2E15_RS18500	COG0729	surface antigen
C2E15_RS18505	COG1253	flavin adenine dinucleotide binding
C2E15_RS18515	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2E15_RS18535	COG0545	Peptidyl-prolyl cis-trans isomerase
C2E15_RS18540	COG3061	Opacity-associated protein A
C2E15_RS18550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2E15_RS18555	COG2965	DNA replication, synthesis of RNA primer
C2E15_RS18565	COG1073	alpha beta
C2E15_RS18570	COG0840	transmembrane signaling receptor activity
C2E15_RS18580	COG1960	acyl-CoA dehydrogenase activity
C2E15_RS18585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2E15_RS18590	COG0557	exoribonuclease II activity
C2E15_RS18600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2E15_RS18605	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2E15_RS18615	COG0330	HflC and HflK could
C2E15_RS18620	COG0330	HflC and HflK could
C2E15_RS18625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2E15_RS18630	COG1923	regulation of RNA biosynthetic process
C2E15_RS18640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2E15_RS18650	COG0802	atpase or kinase
C2E15_RS18655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2E15_RS18655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2E15_RS18660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2E15_RS18690	COG1162	GTPase activity
C2E15_RS18695	COG0688	phosphatidylethanolamine metabolic process
C2E15_RS18700	COG1511	domain protein
C2E15_RS18700	COG3264	Mechanosensitive ion channel
C2E15_RS18705	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C2E15_RS18710	COG0840	transmembrane signaling receptor activity
C2E15_RS18715	COG1053	succinate dehydrogenase
C2E15_RS18720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2E15_RS18745	COG5510	response to toxic substance
C2E15_RS18750	COG5510	response to toxic substance
C2E15_RS18760	COG1509	lysine 2,3-aminomutase activity
C2E15_RS18765	COG0641	radical SAM
C2E15_RS18780	COG3188	usher protein
C2E15_RS18795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2E15_RS18800	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2E15_RS18805	COG1027	Aspartate ammonia-lyase
C2E15_RS18810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2E15_RS18825	COG1309	transcriptional regulator
C2E15_RS18835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2E15_RS18900	COG3039	Transposase
C2E15_RS18920	COG2205	protein histidine kinase activity
C2E15_RS18925	COG0745	RESPONSE REGULATOR receiver
C2E15_RS18930	COG1276	copper resistance
C2E15_RS18935	COG2372	response to copper ion
C2E15_RS18940	COG3667	copper resistance
C2E15_RS18955	COG0739	heme binding
C2E15_RS18985	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2E15_RS19050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2E15_RS19085	COG0431	NADPH-dependent FMN reductase
C2E15_RS19090	COG1393	Belongs to the ArsC family
C2E15_RS19095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2E15_RS19105	COG0789	Transcriptional regulator
C2E15_RS19125	COG4974	Belongs to the 'phage' integrase family
C2E15_RS19135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2E15_RS19280	COG0629	single-stranded DNA binding
C2E15_RS19290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2E15_RS19360	COG2190	(PTS) system
C2E15_RS19360	COG1263	PTS System
C2E15_RS19360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E15_RS19365	COG1609	Transcriptional regulator
C2E15_RS19375	COG3708	Transcriptional regulator
C2E15_RS19375	COG2207	Transcriptional regulator
C2E15_RS19380	COG4993	Dehydrogenase
C2E15_RS19385	COG2814	Major facilitator Superfamily
C2E15_RS19395	COG3546	catalase activity
C2E15_RS19400	COG3685	Protein conserved in bacteria
C2E15_RS19405	COG3729	General stress protein
C2E15_RS19410	COG2207	Transcriptional regulator
C2E15_RS19435	COG0823	Involved in the tonB-independent uptake of proteins
C2E15_RS19460	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2E15_RS19470	COG0840	transmembrane signaling receptor activity
C2E15_RS19475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2E15_RS19480	COG1301	dicarboxylic acid transport
C2E15_RS19490	COG3162	membrane
C2E15_RS19495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2E15_RS19505	COG1380	Effector of murein hydrolase LrgA
C2E15_RS19510	COG0583	DNA-binding transcription factor activity
C2E15_RS19515	COG0025	NhaP-type Na H and K H
C2E15_RS19520	COG2252	PERMEase
C2E15_RS19525	COG0625	glutathione transferase activity
C2E15_RS19530	COG0789	Transcriptional regulator
C2E15_RS19540	COG2199	diguanylate cyclase activity
C2E15_RS19565	COG0840	transmembrane signaling receptor activity
C2E15_RS19570	COG2207	Transcriptional regulator
C2E15_RS19575	COG1486	melibiose metabolic process
C2E15_RS19610	COG0076	glutamate decarboxylase activity
C2E15_RS19615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2E15_RS19620	COG0306	phosphate transporter
C2E15_RS19625	COG2814	Major facilitator Superfamily
C2E15_RS19645	COG0629	single-stranded DNA binding
C2E15_RS19655	COG1064	alcohol dehydrogenase
C2E15_RS19660	COG2315	Protein conserved in bacteria
C2E15_RS19670	COG1448	Aminotransferase
C2E15_RS19680	COG1522	sequence-specific DNA binding
C2E15_RS19710	COG0735	belongs to the Fur family
C2E15_RS19720	COG0534	Mate efflux family protein
C2E15_RS19725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2E15_RS19730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2E15_RS19740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2E15_RS19745	COG3161	chorismate lyase activity
C2E15_RS19755	COG4580	involved in the transport of maltose and maltodextrins
C2E15_RS19765	COG2182	Extracellular solute-binding protein
C2E15_RS19770	COG1175	transmembrane transport
C2E15_RS19780	COG3223	Belongs to the PsiE family
C2E15_RS19785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2E15_RS19815	COG0527	aspartate kinase activity
C2E15_RS19830	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2E15_RS19835	COG1410	methionine synthase
C2E15_RS19835	COG0646	methionine synthase
C2E15_RS19840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2E15_RS19875	COG0151	Belongs to the GarS family
C2E15_RS19890	COG3068	Protein conserved in bacteria
C2E15_RS19900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2E15_RS19905	COG2816	NAD+ diphosphatase activity
C2E15_RS19910	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2E15_RS19915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2E15_RS19925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2E15_RS19930	COG2104	thiamine diphosphate biosynthetic process
C2E15_RS19950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2E15_RS19965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2E15_RS19980	COG0250	Participates in transcription elongation, termination and antitermination
C2E15_RS20020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2E15_RS20020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2E15_RS20025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2E15_RS20055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2E15_RS20060	COG1739	Uncharacterized protein family UPF0029
C2E15_RS20065	COG0006	proline dipeptidase activity
C2E15_RS20070	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2E15_RS20070	COG1024	Enoyl-CoA hydratase
C2E15_RS20095	COG0084	hydrolase, TatD family'
C2E15_RS20100	COG0805	protein transport
C2E15_RS20110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2E15_RS20115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2E15_RS20125	COG2226	methyltransferase
C2E15_RS20130	COG1322	Protein conserved in bacteria
C2E15_RS20140	COG0412	Dienelactone hydrolase
C2E15_RS20145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2E15_RS20150	COG0583	DNA-binding transcription factor activity
C2E15_RS20160	COG0697	spore germination
C2E15_RS20165	COG2271	Major facilitator Superfamily
C2E15_RS20170	COG0584	glycerophosphoryl diester phosphodiesterase
C2E15_RS20180	COG0561	phosphatase activity
C2E15_RS20185	COG2267	carboxylic ester hydrolase activity
C2E15_RS20190	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS20195	COG1280	lysine exporter protein (LysE YggA)
C2E15_RS20205	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C2E15_RS20210	COG2050	protein possibly involved in aromatic compounds catabolism
C2E15_RS20220	COG3180	Ammonia monooxygenase
C2E15_RS20230	COG0210	DNA helicase
C2E15_RS20235	COG1011	Hydrolase
C2E15_RS20250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2E15_RS20280	COG0181	hydroxymethylbilane synthase activity
C2E15_RS20290	COG2959	enzyme of heme biosynthesis
C2E15_RS20295	COG3071	HemY protein
C2E15_RS20335	COG2244	polysaccharide biosynthetic process
C2E15_RS20340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2E15_RS20345	COG0456	acetyltransferase
C2E15_RS20350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2E15_RS20355	COG1088	dTDP-glucose 4,6-dehydratase activity
C2E15_RS20360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2E15_RS20365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2E15_RS20370	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2E15_RS20375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2E15_RS20380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2E15_RS20385	COG3118	belongs to the thioredoxin family
C2E15_RS20395	COG0248	Ppx GppA phosphatase
C2E15_RS20410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2E15_RS20415	COG0583	DNA-binding transcription factor activity
C2E15_RS20425	COG0129	dihydroxy-acid dehydratase activity
C2E15_RS20430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2E15_RS20435	COG3978	acetolactate synthase activity
C2E15_RS20450	COG0606	chelatase, subunit chli
C2E15_RS20455	COG3085	chromosome segregation
C2E15_RS20460	COG0583	DNA-binding transcription factor activity
C2E15_RS20505	COG4206	TonB-dependent receptor
C2E15_RS20520	COG1309	transcriptional regulator
C2E15_RS20525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E15_RS20535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2E15_RS20535	COG0678	peroxiredoxin activity
C2E15_RS20555	COG0137	argininosuccinate synthase activity
C2E15_RS20570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2E15_RS20575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2E15_RS20590	COG0527	aspartate kinase activity
C2E15_RS20590	COG0460	homoserine dehydrogenase
C2E15_RS20595	COG0626	cystathionine gamma-synthase activity
C2E15_RS20600	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
C2E15_RS20610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2E15_RS20615	COG1609	Transcriptional regulator
C2E15_RS20620	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2E15_RS20625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2E15_RS20635	COG1575	Belongs to the MenA family. Type 1 subfamily
C2E15_RS20640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2E15_RS20645	COG3074	FtsZ-dependent cytokinesis
C2E15_RS20650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E15_RS20660	COG1494	fructose-1,6-bisphosphatase
C2E15_RS20665	COG2814	Major facilitator Superfamily
C2E15_RS20675	COG3152	Membrane
C2E15_RS20685	COG0149	triose-phosphate isomerase activity
C2E15_RS20695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2E15_RS20700	COG0205	6-phosphofructokinase activity
C2E15_RS20710	COG3678	ATP-independent chaperone mediated protein folding
C2E15_RS20715	COG0745	RESPONSE REGULATOR receiver
C2E15_RS20720	COG2205	protein histidine kinase activity
C2E15_RS20725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2E15_RS20740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2E15_RS20745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2E15_RS20750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2E15_RS20755	COG4942	peptidase
C2E15_RS20760	COG2861	carbohydrate metabolic process
C2E15_RS20765	COG0438	transferase activity, transferring glycosyl groups
C2E15_RS20785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2E15_RS20795	COG0859	PFAM glycosyl transferase family 9
C2E15_RS20825	COG1216	Glycosyl transferase, family 2
C2E15_RS20830	COG0859	PFAM glycosyl transferase family 9
C2E15_RS20840	COG1519	Transferase
C2E15_RS20855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2E15_RS20860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2E15_RS20870	COG2003	Belongs to the UPF0758 family
C2E15_RS20875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2E15_RS20885	COG1309	transcriptional regulator
C2E15_RS20890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2E15_RS20895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2E15_RS20905	COG1131	(ABC) transporter
C2E15_RS20920	COG1561	YicC-like family, N-terminal region
C2E15_RS20935	COG2244	polysaccharide biosynthetic process
C2E15_RS20940	COG2860	membrane
C2E15_RS20950	COG0194	GDP metabolic process
C2E15_RS20955	COG1758	RNA polymerase activity
C2E15_RS20960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2E15_RS20965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2E15_RS20970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2E15_RS20975	COG2233	PERMEase
C2E15_RS20980	COG2982	Protein involved in outer membrane biogenesis
C2E15_RS20985	COG0456	acetyltransferase
C2E15_RS21000	COG1011	Hydrolase
C2E15_RS21015	COG3852	Histidine kinase
C2E15_RS21020	COG2204	response regulator
C2E15_RS21025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2E15_RS21035	COG3078	GTPase activator activity
C2E15_RS21045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E15_RS21045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E15_RS21050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2E15_RS21060	COG3084	Protein conserved in bacteria
C2E15_RS21065	COG0746	molybdenum cofactor guanylyltransferase activity
C2E15_RS21095	COG0477	Major facilitator Superfamily
C2E15_RS21105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E15_RS21110	COG1879	ABC-type sugar transport system periplasmic component
C2E15_RS21115	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E15_RS21120	COG1129	ABC transporter
C2E15_RS21125	COG1869	D-ribose catabolic process
C2E15_RS21150	COG3111	PFAM Bacterial OB fold (BOF) protein
C2E15_RS21155	COG0745	RESPONSE REGULATOR receiver
C2E15_RS21160	COG0642	Histidine kinase
C2E15_RS21175	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C2E15_RS21180	COG1522	sequence-specific DNA binding
C2E15_RS21185	COG0716	FMN binding