locus-tag	class	description
EJK50_RS00010	COG0592	DNA-directed DNA polymerase activity
EJK50_RS00020	COG0187	DNA topoisomerase II activity
EJK50_RS00025	COG0519	Catalyzes the synthesis of GMP from XMP
EJK50_RS00025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EJK50_RS00050	COG3977	Valine--pyruvate aminotransferase
EJK50_RS00055	COG0251	oxidation-reduction process
EJK50_RS00070	COG1132	(ABC) transporter
EJK50_RS00075	COG0165	Argininosuccinate lyase
EJK50_RS00080	COG0181	hydroxymethylbilane synthase activity
EJK50_RS00090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EJK50_RS00100	COG0443	Heat shock 70 kDa protein
EJK50_RS00140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EJK50_RS00155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EJK50_RS00160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EJK50_RS00165	COG2918	glutathione biosynthetic process
EJK50_RS00170	COG0316	Belongs to the HesB IscA family
EJK50_RS00175	COG1116	anion transmembrane transporter activity
EJK50_RS00175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EJK50_RS00180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EJK50_RS00185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EJK50_RS00185	COG1116	anion transmembrane transporter activity
EJK50_RS00205	COG0488	(ABC) transporter
EJK50_RS00210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EJK50_RS00215	COG0429	hydrolase of the alpha beta-hydrolase fold
EJK50_RS00220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EJK50_RS00225	COG0626	cystathionine gamma-synthase activity
EJK50_RS00230	COG0385	Bile acid
EJK50_RS00235	COG0484	heat shock protein binding
EJK50_RS00250	COG1739	Uncharacterized protein family UPF0029
EJK50_RS00270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EJK50_RS00275	COG0523	cobalamin synthesis protein
EJK50_RS00305	COG2009	succinate dehydrogenase
EJK50_RS00310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EJK50_RS00315	COG1053	succinate dehydrogenase
EJK50_RS00360	COG1505	serine-type exopeptidase activity
EJK50_RS00370	COG0339	signal peptide processing
EJK50_RS00375	COG3568	Endonuclease Exonuclease Phosphatase
EJK50_RS00385	COG0544	peptidyl-prolyl cis-trans isomerase activity
EJK50_RS00390	COG0740	serine-type endopeptidase activity
EJK50_RS00395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EJK50_RS00400	COG0484	heat shock protein binding
EJK50_RS00405	COG1024	Enoyl-CoA hydratase
EJK50_RS00405	COG1250	3-hydroxyacyl-CoA dehydrogenase
EJK50_RS00410	COG0183	Belongs to the thiolase family
EJK50_RS00430	COG2895	sulfate adenylyltransferase (ATP) activity
EJK50_RS00435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EJK50_RS00465	COG0237	dephospho-CoA kinase activity
EJK50_RS00470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EJK50_RS00480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EJK50_RS00485	COG2814	Major facilitator Superfamily
EJK50_RS00490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EJK50_RS00490	COG0047	phosphoribosylformylglycinamidine synthase activity
EJK50_RS00495	COG0786	glutamate:sodium symporter activity
EJK50_RS00500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EJK50_RS00500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EJK50_RS00525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EJK50_RS00540	COG0069	glutamate synthase activity
EJK50_RS00550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EJK50_RS00555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EJK50_RS00560	COG0140	phosphoribosyl-ATP diphosphatase activity
EJK50_RS00560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EJK50_RS00570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EJK50_RS00580	COG1959	2 iron, 2 sulfur cluster binding
EJK50_RS00600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EJK50_RS00605	COG0072	phenylalanine-tRNA ligase activity
EJK50_RS00605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EJK50_RS00610	COG0776	regulation of translation
EJK50_RS00615	COG0254	rRNA binding
EJK50_RS00620	COG3115	cell septum assembly
EJK50_RS00625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EJK50_RS00630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EJK50_RS00640	COG0513	Belongs to the DEAD box helicase family
EJK50_RS00645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EJK50_RS00665	COG2205	protein histidine kinase activity
EJK50_RS00665	COG0784	Response regulator, receiver
EJK50_RS00665	COG5002	protein histidine kinase activity
EJK50_RS00675	COG0688	phosphatidylethanolamine metabolic process
EJK50_RS00680	COG2832	Protein of unknown function (DUF454)
EJK50_RS00695	COG4106	trans-aconitate 2-methyltransferase activity
EJK50_RS00705	COG1490	D-aminoacyl-tRNA deacylase activity
EJK50_RS00715	COG0494	nUDIX hydrolase
EJK50_RS00735	COG0629	single-stranded DNA binding
EJK50_RS00740	COG0754	glutathionylspermidine amidase activity
EJK50_RS00755	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EJK50_RS00760	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EJK50_RS00775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EJK50_RS00785	COG0745	RESPONSE REGULATOR receiver
EJK50_RS00800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EJK50_RS00815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EJK50_RS00830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EJK50_RS00835	COG0644	oxidoreductase
EJK50_RS00835	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EJK50_RS00845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EJK50_RS00855	COG2951	lytic endotransglycosylase activity
EJK50_RS00860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJK50_RS00865	COG4106	trans-aconitate 2-methyltransferase activity
EJK50_RS00870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EJK50_RS00875	COG2354	Protein conserved in bacteria
EJK50_RS00900	COG2195	Cleaves the N-terminal amino acid of tripeptides
EJK50_RS00905	COG0412	Dienelactone hydrolase
EJK50_RS00910	COG2983	Belongs to the UPF0260 family
EJK50_RS00915	COG4535	Mg2 and Co2 transporter CorC
EJK50_RS00920	COG0354	folic acid binding
EJK50_RS00925	COG2824	Alkylphosphonate utilization operon protein PhnA
EJK50_RS00930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EJK50_RS00935	COG0653	protein targeting
EJK50_RS00990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EJK50_RS00995	COG0049	tRNA binding
EJK50_RS01005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EJK50_RS01010	COG0492	ferredoxin-NADP+ reductase activity
EJK50_RS01015	COG1960	acyl-CoA dehydrogenase activity
EJK50_RS01020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EJK50_RS01035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EJK50_RS01040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EJK50_RS01045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EJK50_RS01055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EJK50_RS01060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EJK50_RS01085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EJK50_RS01120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EJK50_RS01140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EJK50_RS01145	COG0081	regulation of translation
EJK50_RS01155	COG0222	ribosome binding
EJK50_RS01160	COG0085	RNA polymerase activity
EJK50_RS01165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EJK50_RS01170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EJK50_RS01175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EJK50_RS01185	COG0793	Belongs to the peptidase S41A family
EJK50_RS01190	COG5487	UPF0391 membrane protein
EJK50_RS01200	COG0730	response to heat
EJK50_RS01210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EJK50_RS01220	COG1765	OsmC-like protein
EJK50_RS01225	COG0494	nUDIX hydrolase
EJK50_RS01230	COG1196	nuclear chromosome segregation
EJK50_RS01235	COG0052	Belongs to the universal ribosomal protein uS2 family
EJK50_RS01240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EJK50_RS01250	COG0189	ligase activity
EJK50_RS01255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EJK50_RS01260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EJK50_RS01265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EJK50_RS01280	COG0583	DNA-binding transcription factor activity
EJK50_RS01285	COG0450	alkyl hydroperoxide reductase
EJK50_RS01300	COG3634	alkyl hydroperoxide reductase activity
EJK50_RS01305	COG2975	iron-sulfur cluster assembly
EJK50_RS01325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EJK50_RS01340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EJK50_RS01345	COG1183	phosphatidylcholine synthase activity
EJK50_RS01385	COG0586	Pfam SNARE associated Golgi protein
EJK50_RS01390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EJK50_RS01395	COG0849	cell division
EJK50_RS01400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EJK50_RS01410	COG2137	regulation of response to DNA damage stimulus
EJK50_RS01415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EJK50_RS01430	COG0277	FAD linked oxidase domain protein
EJK50_RS01450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EJK50_RS01455	COG2171	N-acyltransferase activity
EJK50_RS01465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EJK50_RS01470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EJK50_RS01490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EJK50_RS01505	COG0586	Pfam SNARE associated Golgi protein
EJK50_RS01510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EJK50_RS01515	COG0735	belongs to the Fur family
EJK50_RS01555	COG0196	riboflavin kinase activity
EJK50_RS01560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EJK50_RS01575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EJK50_RS01580	COG2837	iron assimilation
EJK50_RS01595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EJK50_RS01600	COG1758	RNA polymerase activity
EJK50_RS01605	COG0194	GDP metabolic process
EJK50_RS01610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EJK50_RS01620	COG2860	membrane
EJK50_RS01625	COG0602	queuosine metabolic process
EJK50_RS01630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EJK50_RS01650	COG0732	type I restriction modification DNA specificity domain
EJK50_RS01670	COG0076	glutamate decarboxylase activity
EJK50_RS01675	COG0322	excinuclease ABC activity
EJK50_RS01680	COG0546	phosphoglycolate phosphatase activity
EJK50_RS01690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EJK50_RS01695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EJK50_RS01705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EJK50_RS01710	COG1121	(ABC) transporter
EJK50_RS01715	COG0735	belongs to the Fur family
EJK50_RS01730	COG0356	it plays a direct role in the translocation of protons across the membrane
EJK50_RS01740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EJK50_RS01745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EJK50_RS01750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EJK50_RS01755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EJK50_RS01765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EJK50_RS01770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EJK50_RS01775	COG0745	RESPONSE REGULATOR receiver
EJK50_RS01780	COG2205	protein histidine kinase activity
EJK50_RS01790	COG0228	four-way junction DNA binding
EJK50_RS01795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EJK50_RS01800	COG0336	Belongs to the RNA methyltransferase TrmD family
EJK50_RS01805	COG0335	large ribosomal subunit rRNA binding
EJK50_RS01820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EJK50_RS01825	COG2986	histidine ammonia-lyase
EJK50_RS01830	COG0010	Belongs to the arginase family
EJK50_RS01835	COG1228	amidohydrolase
EJK50_RS01855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EJK50_RS01860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EJK50_RS01865	COG0540	Belongs to the ATCase OTCase family
EJK50_RS01880	COG2301	Belongs to the HpcH HpaI aldolase family
EJK50_RS01890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EJK50_RS01895	COG0628	permease
EJK50_RS01900	COG1671	Belongs to the UPF0178 family
EJK50_RS01910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EJK50_RS01925	COG1981	membrane
EJK50_RS01935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EJK50_RS01965	COG0393	Putative heavy-metal-binding
EJK50_RS01985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EJK50_RS01990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EJK50_RS02010	COG1534	Rna-binding protein
EJK50_RS02015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EJK50_RS02020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EJK50_RS02035	COG0326	Molecular chaperone. Has ATPase activity
EJK50_RS02050	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EJK50_RS02055	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EJK50_RS02070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EJK50_RS02085	COG0531	amino acid
EJK50_RS02095	COG0617	tRNA 3'-terminal CCA addition
EJK50_RS02115	COG2255	four-way junction helicase activity
EJK50_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
EJK50_RS02135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EJK50_RS02150	COG0129	dihydroxy-acid dehydratase activity
EJK50_RS02160	COG0628	permease
EJK50_RS02170	COG0537	adenosine 5'-monophosphoramidase activity
EJK50_RS02180	COG1720	tRNA m6t6A37 methyltransferase activity
EJK50_RS02200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EJK50_RS02210	COG1538	Outer membrane efflux protein
EJK50_RS02220	COG0277	FAD linked oxidase domain protein
EJK50_RS02225	COG0826	peptidase U32
EJK50_RS02240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EJK50_RS02255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EJK50_RS02265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EJK50_RS02280	COG1629	transport
EJK50_RS02290	COG2264	protein methyltransferase activity
EJK50_RS02295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EJK50_RS02305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EJK50_RS02310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EJK50_RS02330	COG2233	PERMEase
EJK50_RS02335	COG1115	amino acid carrier protein
EJK50_RS02340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EJK50_RS02360	COG0728	peptidoglycan biosynthetic process
EJK50_RS02365	COG3023	N-Acetylmuramoyl-L-alanine amidase
EJK50_RS02380	COG0471	metal ion transport
EJK50_RS02385	COG0525	valine-tRNA ligase activity
EJK50_RS02410	COG0123	including yeast histone deacetylase and acetoin utilization protein
EJK50_RS02420	COG4133	protoheme IX ABC transporter activity
EJK50_RS02430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EJK50_RS02440	COG2363	Small membrane protein
EJK50_RS02460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EJK50_RS02465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EJK50_RS02470	COG0528	UMP kinase activity
EJK50_RS02475	COG0233	cytoplasmic translational termination
EJK50_RS02480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EJK50_RS02485	COG0575	Belongs to the CDS family
EJK50_RS02490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EJK50_RS02505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJK50_RS02510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EJK50_RS02515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJK50_RS02520	COG0733	neurotransmitter:sodium symporter activity
EJK50_RS02535	COG1294	oxidase, subunit
EJK50_RS02555	COG1115	amino acid carrier protein
EJK50_RS02580	COG0778	Nitroreductase
EJK50_RS02585	COG1902	pentaerythritol trinitrate reductase activity
EJK50_RS02590	COG0583	DNA-binding transcription factor activity
EJK50_RS02595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EJK50_RS02600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EJK50_RS02615	COG0628	permease
EJK50_RS02620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EJK50_RS02625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EJK50_RS02645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EJK50_RS02650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EJK50_RS02660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EJK50_RS02665	COG0527	aspartate kinase activity
EJK50_RS02685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EJK50_RS02705	COG0482	sulfurtransferase activity
EJK50_RS02715	COG1335	isochorismatase
EJK50_RS02720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EJK50_RS02745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EJK50_RS02750	COG0316	Belongs to the HesB IscA family
EJK50_RS02755	COG0822	iron-sulfur transferase activity
EJK50_RS02765	COG1959	2 iron, 2 sulfur cluster binding
EJK50_RS02785	COG0138	bifunctional purine biosynthesis protein purh
EJK50_RS02790	COG5295	Hep Hag repeat protein
EJK50_RS02800	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EJK50_RS02805	COG2264	protein methyltransferase activity
EJK50_RS02815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EJK50_RS02820	COG2217	Heavy metal translocating P-type atpase
EJK50_RS02830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EJK50_RS02840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EJK50_RS02845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EJK50_RS02860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EJK50_RS02875	COG2321	neutral zinc metallopeptidase
EJK50_RS02915	COG4591	ABC-type transport system involved in lipoprotein release permease component
EJK50_RS02920	COG1136	(ABC) transporter
EJK50_RS02930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EJK50_RS02940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EJK50_RS02950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJK50_RS02960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EJK50_RS02965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EJK50_RS02970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EJK50_RS02975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EJK50_RS02985	COG3753	Protein conserved in bacteria
EJK50_RS02990	COG0560	Phosphoserine phosphatase
EJK50_RS03005	COG1960	acyl-CoA dehydrogenase activity
EJK50_RS03035	COG0741	lytic transglycosylase activity
EJK50_RS03035	COG0739	heme binding
EJK50_RS03035	COG1196	nuclear chromosome segregation
EJK50_RS03040	COG0501	Belongs to the peptidase M48B family
EJK50_RS03045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EJK50_RS03050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EJK50_RS03055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EJK50_RS03065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EJK50_RS03095	COG0668	transmembrane transport
EJK50_RS03100	COG0084	hydrolase, TatD family'
EJK50_RS03105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EJK50_RS03120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EJK50_RS03125	COG0259	pyridoxamine-phosphate oxidase activity
EJK50_RS03135	COG2608	mercury ion transmembrane transporter activity
EJK50_RS03140	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EJK50_RS03145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EJK50_RS03150	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EJK50_RS03150	COG0649	NAD binding
EJK50_RS03165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EJK50_RS03170	COG1034	ATP synthesis coupled electron transport
EJK50_RS03175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EJK50_RS03180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EJK50_RS03185	COG0839	Belongs to the complex I subunit 6 family
EJK50_RS03190	COG0713	ATP synthesis coupled electron transport
EJK50_RS03205	COG1007	ATP synthesis coupled electron transport
EJK50_RS03210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EJK50_RS03210	COG0678	peroxiredoxin activity
EJK50_RS03215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EJK50_RS03220	COG0018	arginyl-trna synthetase
EJK50_RS03235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EJK50_RS03240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EJK50_RS03245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EJK50_RS03250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EJK50_RS03265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EJK50_RS03270	COG0217	transcriptional regulatory protein
EJK50_RS03275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EJK50_RS03290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EJK50_RS03295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EJK50_RS03310	COG0301	tRNA thio-modification
EJK50_RS03310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EJK50_RS03335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EJK50_RS03340	COG1140	nitrate reductase beta subunit
EJK50_RS03345	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EJK50_RS03350	COG2181	nitrate reductase activity
EJK50_RS03360	COG0303	'Molybdopterin
EJK50_RS03370	COG4149	molybdate abc transporter
EJK50_RS03375	COG0725	ABC transporter, periplasmic molybdate-binding protein
EJK50_RS03385	COG0314	molybdopterin synthase activity
EJK50_RS03390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EJK50_RS03395	COG0315	cyclic pyranopterin monophosphate synthase activity
EJK50_RS03400	COG0746	molybdenum cofactor guanylyltransferase activity
EJK50_RS03405	COG0521	Mo-molybdopterin cofactor biosynthetic process
EJK50_RS03410	COG2258	MOSC domain
EJK50_RS03415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EJK50_RS03420	COG2197	response regulator
EJK50_RS03425	COG3850	Histidine kinase
EJK50_RS03435	COG2223	nitrite transmembrane transporter activity
EJK50_RS03485	COG3210	domain, Protein
EJK50_RS03520	COG3210	domain, Protein
EJK50_RS03590	COG2026	Addiction module toxin, RelE StbE family
EJK50_RS03630	COG1192	Involved in chromosome partitioning
EJK50_RS03635	COG1475	DNA binding
EJK50_RS03820	COG1012	belongs to the aldehyde dehydrogenase family
EJK50_RS03830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EJK50_RS03850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EJK50_RS03880	COG2056	Na+-H+ antiporter family
EJK50_RS03885	COG0475	glutathione-regulated potassium exporter activity
EJK50_RS03885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EJK50_RS03890	COG0598	Magnesium transport protein CorA
EJK50_RS03895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EJK50_RS03900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EJK50_RS03915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EJK50_RS03920	COG1067	ATP-dependent peptidase activity
EJK50_RS03925	COG0357	Ribosomal RNA small subunit methyltransferase G
EJK50_RS03930	COG1192	Involved in chromosome partitioning
EJK50_RS03940	COG1475	DNA binding
EJK50_RS03945	COG1663	tetraacyldisaccharide 4'-kinase activity
EJK50_RS03950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EJK50_RS03965	COG1304	FMN binding
EJK50_RS03970	COG1620	l-lactate permease
EJK50_RS03975	COG0708	Exodeoxyribonuclease III
EJK50_RS03980	COG1309	transcriptional regulator
EJK50_RS03995	COG0105	UTP biosynthetic process
EJK50_RS04010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EJK50_RS04020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EJK50_RS04035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EJK50_RS04040	COG1702	phosphate starvation-inducible protein PhoH
EJK50_RS04050	COG0511	ligase activity, forming carbon-carbon bonds
EJK50_RS04060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EJK50_RS04065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EJK50_RS04070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EJK50_RS04075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EJK50_RS04090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EJK50_RS04095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EJK50_RS04105	COG0134	indole-3-glycerol-phosphate synthase activity
EJK50_RS04110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EJK50_RS04125	COG1560	Kdo2-lipid A biosynthetic process
EJK50_RS04130	COG0488	(ABC) transporter
EJK50_RS04135	COG2900	Belongs to the SlyX family
EJK50_RS04150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EJK50_RS04170	COG0590	tRNA wobble adenosine to inosine editing
EJK50_RS04175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EJK50_RS04185	COG0776	regulation of translation
EJK50_RS04195	COG0284	orotidine-5'-phosphate decarboxylase activity
EJK50_RS04200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EJK50_RS04205	COG2095	MarC family integral membrane protein
EJK50_RS04210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EJK50_RS04210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EJK50_RS04215	COG2350	Protein conserved in bacteria
EJK50_RS04230	COG2816	NAD+ diphosphatase activity
EJK50_RS04240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EJK50_RS04255	COG0151	Belongs to the GarS family
EJK50_RS04260	COG0179	Fumarylacetoacetate (FAA) hydrolase
EJK50_RS04270	COG1773	rubredoxin
EJK50_RS04280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EJK50_RS04310	COG0625	glutathione transferase activity
EJK50_RS04330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EJK50_RS04335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EJK50_RS04345	COG0019	diaminopimelate decarboxylase activity
EJK50_RS04360	COG0802	atpase or kinase
EJK50_RS04365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EJK50_RS04370	COG1923	regulation of RNA biosynthetic process
EJK50_RS04375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EJK50_RS04375	COG0517	IMP dehydrogenase activity
EJK50_RS04380	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EJK50_RS04395	COG1137	ATPase activity
EJK50_RS04415	COG0612	Peptidase, M16
EJK50_RS04425	COG0552	protein localization to endoplasmic reticulum
EJK50_RS04435	COG0167	dihydroorotate dehydrogenase activity
EJK50_RS04455	COG0556	nucleotide-excision repair
EJK50_RS04465	COG1074	ATP-dependent DNA helicase activity
EJK50_RS04470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EJK50_RS04475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EJK50_RS04480	COG1570	exodeoxyribonuclease VII activity
EJK50_RS04485	COG2326	polyphosphate kinase activity
EJK50_RS04515	COG4197	protein conserved in bacteria, prophage-related
EJK50_RS04635	COG1598	PFAM Uncharacterised protein family UPF0150
EJK50_RS04665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EJK50_RS04675	COG1643	Atp-dependent helicase
EJK50_RS04695	COG0823	Involved in the tonB-independent uptake of proteins
EJK50_RS04705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EJK50_RS04710	COG0352	thiamine-phosphate diphosphorylase activity
EJK50_RS04735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EJK50_RS04745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EJK50_RS04750	COG0513	Belongs to the DEAD box helicase family
EJK50_RS04760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EJK50_RS04765	COG4208	sulfate ABC transporter
EJK50_RS04785	COG0741	lytic transglycosylase activity
EJK50_RS04785	COG1388	LysM domain
EJK50_RS04795	COG1253	flavin adenine dinucleotide binding
EJK50_RS04800	COG1862	Preprotein translocase
EJK50_RS04815	COG1686	Belongs to the peptidase S11 family
EJK50_RS04820	COG1757	Na H antiporter
EJK50_RS04835	COG0583	DNA-binding transcription factor activity
EJK50_RS04845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EJK50_RS04855	COG0708	Exodeoxyribonuclease III
EJK50_RS04860	COG0824	Thioesterase
EJK50_RS04885	COG0583	DNA-binding transcription factor activity
EJK50_RS04890	COG0632	four-way junction helicase activity
EJK50_RS04895	COG0191	fructose-bisphosphate aldolase activity
EJK50_RS04905	COG0126	phosphoglycerate kinase activity
EJK50_RS04910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EJK50_RS04915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EJK50_RS04920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EJK50_RS04925	COG0305	Participates in initiation and elongation during chromosome replication
EJK50_RS04930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EJK50_RS04955	COG1760	l-serine dehydratase
EJK50_RS04970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EJK50_RS04975	COG0542	response to heat
EJK50_RS04980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EJK50_RS04990	COG2217	Heavy metal translocating P-type atpase
EJK50_RS04995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EJK50_RS05015	COG0358	DNA primase activity
EJK50_RS05040	COG0268	Binds directly to 16S ribosomal RNA
EJK50_RS05045	COG2197	response regulator
EJK50_RS05050	COG0793	Belongs to the peptidase S41A family
EJK50_RS05055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EJK50_RS05065	COG2252	PERMEase
EJK50_RS05070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EJK50_RS05075	COG0438	transferase activity, transferring glycosyl groups
EJK50_RS05080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EJK50_RS05085	COG4988	ABC transporter
EJK50_RS05095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EJK50_RS05115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EJK50_RS05125	COG0302	gtp cyclohydrolase
EJK50_RS05130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EJK50_RS05135	COG0477	Major facilitator Superfamily
EJK50_RS05145	COG2431	L-lysine efflux transmembrane transporter activity
EJK50_RS05150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EJK50_RS05175	COG0463	Glycosyl transferase, family 2
EJK50_RS05210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EJK50_RS05215	COG0037	tRNA processing
EJK50_RS05220	COG0116	Belongs to the methyltransferase superfamily
EJK50_RS05220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EJK50_RS05235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EJK50_RS05240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EJK50_RS05245	COG1876	peptidase activity
EJK50_RS05250	COG3781	membrane
EJK50_RS05265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EJK50_RS05270	COG3178	'Phosphotransferase
EJK50_RS05275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EJK50_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EJK50_RS05285	COG4942	peptidase
EJK50_RS05295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EJK50_RS05300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EJK50_RS05305	COG1755	Isoprenylcysteine carboxyl methyltransferase
EJK50_RS05325	COG0505	Belongs to the CarA family
EJK50_RS05330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJK50_RS05335	COG0436	Aminotransferase
EJK50_RS05355	COG1648	precorrin-2 dehydrogenase activity
EJK50_RS05355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EJK50_RS05385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EJK50_RS05405	COG1607	acyl-coa hydrolase
EJK50_RS05410	COG1160	GTP binding
EJK50_RS05420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EJK50_RS05425	COG2890	protein-(glutamine-N5) methyltransferase activity
EJK50_RS05430	COG2211	Major facilitator Superfamily
EJK50_RS05435	COG0583	DNA-binding transcription factor activity
EJK50_RS05440	COG0471	metal ion transport
EJK50_RS05455	COG0321	lipoyl(octanoyl) transferase activity
EJK50_RS05470	COG3012	SEC-C Motif Domain Protein
EJK50_RS05480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EJK50_RS05495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EJK50_RS05505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJK50_RS05510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EJK50_RS05515	COG1160	GTP binding
EJK50_RS05520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EJK50_RS05530	COG0124	histidyl-tRNA synthetase
EJK50_RS05540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EJK50_RS05550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EJK50_RS05560	COG2850	peptidyl-arginine hydroxylation
EJK50_RS05565	COG0587	DNA-directed DNA polymerase activity
EJK50_RS05575	COG1045	serine acetyltransferase
EJK50_RS05580	COG2818	Glycosylase
EJK50_RS05585	COG0668	transmembrane transport
EJK50_RS05595	COG0616	signal peptide processing
EJK50_RS05600	COG3263	regulation of cellular component size
EJK50_RS05605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EJK50_RS05635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EJK50_RS05640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EJK50_RS05645	COG2966	Psort location CytoplasmicMembrane, score
EJK50_RS05650	COG3610	response to peptide
EJK50_RS05660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EJK50_RS05690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EJK50_RS05695	COG1116	anion transmembrane transporter activity
EJK50_RS05700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EJK50_RS05705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EJK50_RS05745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EJK50_RS05750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EJK50_RS05755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EJK50_RS05760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EJK50_RS05775	COG0494	nUDIX hydrolase
EJK50_RS05790	COG0729	surface antigen
EJK50_RS05795	COG2814	Major facilitator Superfamily
EJK50_RS05810	COG0563	adenylate kinase activity
EJK50_RS05840	COG0742	ribosomal rna small subunit methyltransferase
EJK50_RS05860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EJK50_RS05880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EJK50_RS05880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EJK50_RS05885	COG0585	pseudouridine synthase activity
EJK50_RS05895	COG0717	Belongs to the dCTP deaminase family
EJK50_RS05925	COG1346	cytolysis
EJK50_RS05930	COG1380	Effector of murein hydrolase LrgA
EJK50_RS05935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EJK50_RS05940	COG2814	Major facilitator Superfamily
EJK50_RS05945	COG0210	DNA helicase
EJK50_RS05950	COG1162	GTPase activity
EJK50_RS05955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EJK50_RS05965	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EJK50_RS05970	COG0756	dUTP diphosphatase activity
EJK50_RS05975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EJK50_RS05985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EJK50_RS05990	COG0431	NADPH-dependent FMN reductase
EJK50_RS06000	COG0359	binds to the 23S rRNA
EJK50_RS06005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EJK50_RS06010	COG0360	Binds together with S18 to 16S ribosomal RNA
EJK50_RS06020	COG3100	YcgL domain-containing protein
EJK50_RS06030	COG0509	glycine decarboxylation via glycine cleavage system
EJK50_RS06035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EJK50_RS06035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EJK50_RS06040	COG1966	Carbon starvation protein
EJK50_RS06055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EJK50_RS06065	COG0489	protein tyrosine kinase activity
EJK50_RS06070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EJK50_RS06075	COG0343	queuine tRNA-ribosyltransferase activity
EJK50_RS06090	COG1393	Belongs to the ArsC family
EJK50_RS06095	COG0495	leucyl-tRNA aminoacylation
EJK50_RS06140	COG4166	transmembrane transport
EJK50_RS06150	COG0444	Belongs to the ABC transporter superfamily
EJK50_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EJK50_RS06160	COG0601	transmembrane transport
EJK50_RS06165	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EJK50_RS06185	COG0616	signal peptide processing
EJK50_RS06185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EJK50_RS06190	COG2333	competence protein COMEC
EJK50_RS06190	COG0658	competence protein
EJK50_RS06195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EJK50_RS06200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EJK50_RS06205	COG0148	phosphopyruvate hydratase activity
EJK50_RS06215	COG0504	CTP synthase activity
EJK50_RS06220	COG2010	Cytochrome c
EJK50_RS06235	COG3278	Belongs to the heme-copper respiratory oxidase family
EJK50_RS06245	COG0348	domain, Protein
EJK50_RS06260	COG1376	ErfK ybiS ycfS ynhG family protein
EJK50_RS06290	COG1741	Belongs to the pirin family
EJK50_RS06300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EJK50_RS06310	COG0742	ribosomal rna small subunit methyltransferase
EJK50_RS06315	COG1968	undecaprenyl-diphosphatase activity
EJK50_RS06320	COG1214	PFAM Peptidase M22, glycoprotease
EJK50_RS06325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EJK50_RS06340	COG0420	3'-5' exonuclease activity
EJK50_RS06345	COG0419	ATPase involved in DNA repair
EJK50_RS06360	COG0445	tRNA wobble uridine modification
EJK50_RS06370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EJK50_RS06380	COG0723	plastoquinol--plastocyanin reductase activity
EJK50_RS06385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EJK50_RS06390	COG2857	Cytochrome c1
EJK50_RS06395	COG0625	glutathione transferase activity
EJK50_RS06400	COG2969	positive regulation of protein catabolic process
EJK50_RS06415	COG1122	ATPase activity
EJK50_RS06420	COG4120	Belongs to the binding-protein-dependent transport system permease family
EJK50_RS06440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EJK50_RS06445	COG1696	Membrane protein involved in D-alanine export
EJK50_RS06465	COG1519	Transferase
EJK50_RS06470	COG0308	aminopeptidase N
EJK50_RS06475	COG2885	chlorophyll binding
EJK50_RS06520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EJK50_RS06525	COG0318	PFAM AMP-dependent synthetase and ligase
EJK50_RS06535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EJK50_RS06540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EJK50_RS06550	COG2914	Belongs to the UPF0125 (RnfH) family
EJK50_RS06575	COG0215	cysteine-tRNA ligase activity
EJK50_RS06580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EJK50_RS06580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EJK50_RS06585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EJK50_RS06590	COG2022	thiamine diphosphate biosynthetic process
EJK50_RS06610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EJK50_RS06640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EJK50_RS06655	COG0408	coproporphyrinogen oxidase activity
EJK50_RS06680	COG0285	dihydrofolate synthase activity
EJK50_RS06690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EJK50_RS06695	COG0159	tryptophan synthase activity
EJK50_RS06710	COG0442	prolyl-tRNA aminoacylation
EJK50_RS06715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EJK50_RS06715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EJK50_RS06720	COG0842	Transport permease protein
EJK50_RS06725	COG1131	(ABC) transporter
EJK50_RS06755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EJK50_RS06760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EJK50_RS06785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EJK50_RS06790	COG0741	lytic transglycosylase activity
EJK50_RS06845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EJK50_RS06865	COG0557	exoribonuclease II activity
EJK50_RS06870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EJK50_RS06875	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJK50_RS06880	COG1805	sodium ion transport
EJK50_RS06885	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJK50_RS06890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJK50_RS06895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJK50_RS06900	COG2871	sodium ion transport
EJK50_RS06905	COG0753	catalase activity
EJK50_RS06910	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EJK50_RS06915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EJK50_RS06930	COG1047	Peptidyl-prolyl cis-trans
EJK50_RS06940	COG1187	pseudouridine synthase activity
EJK50_RS06945	COG2885	chlorophyll binding
EJK50_RS06955	COG1024	Enoyl-CoA hydratase
EJK50_RS06960	COG3022	response to hydroperoxide
EJK50_RS06965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EJK50_RS06970	COG0280	phosphate acetyltransferase
EJK50_RS06970	COG0857	belongs to the CobB CobQ family
EJK50_RS06975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EJK50_RS06985	COG0019	diaminopimelate decarboxylase activity
EJK50_RS06990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EJK50_RS07010	COG1477	protein flavinylation
EJK50_RS07015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EJK50_RS07020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EJK50_RS07025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EJK50_RS07030	COG0459	protein refolding
EJK50_RS07035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EJK50_RS07055	COG1295	ribonuclease BN
EJK50_RS07070	COG0358	DNA primase activity
EJK50_RS07120	COG0582	viral genome integration into host DNA
EJK50_RS07140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EJK50_RS07145	COG0024	Methionine aminopeptidase
EJK50_RS07150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EJK50_RS07150	COG3453	Protein conserved in bacteria
EJK50_RS07155	COG1902	pentaerythritol trinitrate reductase activity
EJK50_RS07155	COG0446	pyridine nucleotide-disulphide oxidoreductase
EJK50_RS07160	COG0606	chelatase, subunit chli
EJK50_RS07165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EJK50_RS07170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EJK50_RS07180	COG0142	geranyltranstransferase activity
EJK50_RS07185	COG1194	a g-specific adenine glycosylase
EJK50_RS07205	COG0347	Belongs to the P(II) protein family
EJK50_RS07210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EJK50_RS07215	COG0772	Belongs to the SEDS family
EJK50_RS07230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EJK50_RS07235	COG1278	Cold shock
EJK50_RS07250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EJK50_RS07255	COG0440	acetolactate synthase activity
EJK50_RS07260	COG0028	Belongs to the TPP enzyme family
EJK50_RS07270	COG1652	LysM domain
EJK50_RS07290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EJK50_RS07300	COG3101	peptidyl-lysine hydroxylation
EJK50_RS07305	COG0009	L-threonylcarbamoyladenylate synthase
EJK50_RS07310	COG0203	ribosomal protein L17
EJK50_RS07315	COG0202	RNA polymerase activity
EJK50_RS07320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EJK50_RS07325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EJK50_RS07345	COG0200	Binds to the 23S rRNA
EJK50_RS07350	COG1841	ribosomal large subunit assembly
EJK50_RS07360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EJK50_RS07365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EJK50_RS07370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EJK50_RS07375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EJK50_RS07380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EJK50_RS07385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EJK50_RS07390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EJK50_RS07395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EJK50_RS07400	COG0255	Belongs to the universal ribosomal protein uL29 family
EJK50_RS07405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EJK50_RS07410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EJK50_RS07415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EJK50_RS07420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EJK50_RS07425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EJK50_RS07430	COG0089	rRNA binding
EJK50_RS07435	COG0088	Forms part of the polypeptide exit tunnel
EJK50_RS07440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EJK50_RS07445	COG0051	transcription antitermination factor activity, RNA binding
EJK50_RS07455	COG0424	maF-like protein
EJK50_RS07460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EJK50_RS07465	COG0154	amidase activity
EJK50_RS07470	COG2367	Beta-lactamase
EJK50_RS07475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EJK50_RS07490	COG2885	chlorophyll binding
EJK50_RS07495	COG0204	Acyl-transferase
EJK50_RS07505	COG0850	regulation of cytokinetic process
EJK50_RS07515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EJK50_RS07520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EJK50_RS07525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EJK50_RS07530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EJK50_RS07535	COG0193	aminoacyl-tRNA hydrolase activity
EJK50_RS07540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EJK50_RS07560	COG0351	phosphomethylpyrimidine kinase
EJK50_RS07560	COG0352	thiamine-phosphate diphosphorylase activity
EJK50_RS07560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EJK50_RS07570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EJK50_RS07575	COG0037	tRNA processing
EJK50_RS07585	COG0248	Ppx GppA phosphatase
EJK50_RS07590	COG0564	pseudouridine synthase activity
EJK50_RS07595	COG1530	ribonuclease E activity
EJK50_RS07600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EJK50_RS07610	COG3161	chorismate lyase activity
EJK50_RS07620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EJK50_RS07695	COG0752	glycyl-tRNA synthetase alpha subunit
EJK50_RS07720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EJK50_RS07725	COG2081	HI0933 family
EJK50_RS07740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EJK50_RS07745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EJK50_RS07750	COG1051	belongs to the nudix hydrolase family
EJK50_RS07750	COG1056	cytidyltransferase-related domain
EJK50_RS07755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EJK50_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
EJK50_RS07770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EJK50_RS07770	COG0425	Belongs to the sulfur carrier protein TusA family
EJK50_RS07790	COG0488	(ABC) transporter
EJK50_RS07840	COG2154	pterin-4-alpha-carbinolamine dehydratase
EJK50_RS07845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EJK50_RS07850	COG2226	methyltransferase
EJK50_RS07860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EJK50_RS07870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EJK50_RS07870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EJK50_RS07885	COG1674	ftsk spoiiie
EJK50_RS07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EJK50_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EJK50_RS07920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EJK50_RS07925	COG1217	gtp-binding protein TYPA
EJK50_RS07935	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EJK50_RS07940	COG1381	Involved in DNA repair and RecF pathway recombination
EJK50_RS07945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EJK50_RS07950	COG0571	ribonuclease III activity
EJK50_RS07960	COG0481	GTPase activity
EJK50_RS08020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EJK50_RS08035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EJK50_RS08050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EJK50_RS08065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EJK50_RS08075	COG3842	ATPase activity
EJK50_RS08120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EJK50_RS08125	COG0581	inorganic phosphate transmembrane transporter activity
EJK50_RS08130	COG0573	inorganic phosphate transmembrane transporter activity
EJK50_RS08145	COG0271	Belongs to the BolA IbaG family
EJK50_RS08150	COG0659	secondary active sulfate transmembrane transporter activity
EJK50_RS08160	COG0564	pseudouridine synthase activity
EJK50_RS08180	COG1764	response to oxidative stress
EJK50_RS08185	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EJK50_RS08185	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EJK50_RS08190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EJK50_RS08195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EJK50_RS08200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EJK50_RS08205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EJK50_RS08230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EJK50_RS08235	COG1185	polyribonucleotide nucleotidyltransferase activity
EJK50_RS08240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EJK50_RS08250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EJK50_RS08255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EJK50_RS08260	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
EJK50_RS08270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EJK50_RS08275	COG2251	uridine kinase activity
EJK50_RS08275	COG0195	Participates in both transcription termination and antitermination
EJK50_RS08280	COG0779	Required for maturation of 30S ribosomal subunits
EJK50_RS08305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EJK50_RS08310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EJK50_RS08335	COG0275	rRNA processing
EJK50_RS08340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EJK50_RS08365	COG0121	glutamine amidotransferase
EJK50_RS08370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EJK50_RS08375	COG0107	imidazoleglycerol-phosphate synthase activity
EJK50_RS08385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EJK50_RS08390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EJK50_RS08395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EJK50_RS08430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EJK50_RS08440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EJK50_RS08465	COG0166	Belongs to the GPI family
EJK50_RS08470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EJK50_RS08475	COG2937	Belongs to the GPAT DAPAT family
EJK50_RS08480	COG1946	Acyl-CoA thioesterase
EJK50_RS08490	COG0795	lipopolysaccharide-transporting ATPase activity
EJK50_RS08495	COG0795	lipopolysaccharide-transporting ATPase activity
EJK50_RS08500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EJK50_RS08505	COG1448	Aminotransferase
EJK50_RS08510	COG0583	DNA-binding transcription factor activity
EJK50_RS08515	COG0387	Pfam Sodium calcium exchanger
EJK50_RS08520	COG1253	flavin adenine dinucleotide binding
EJK50_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
EJK50_RS08530	COG0546	phosphoglycolate phosphatase activity
EJK50_RS08535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EJK50_RS08540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EJK50_RS08565	COG1660	Displays ATPase and GTPase activities
EJK50_RS08570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EJK50_RS08575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EJK50_RS08580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EJK50_RS08585	COG0617	tRNA 3'-terminal CCA addition
EJK50_RS08590	COG1596	polysaccharide export
EJK50_RS08590	COG1555	photosystem II stabilization
EJK50_RS08595	COG3956	TIGRFAM MazG family protein
EJK50_RS08630	COG1585	Membrane protein implicated in regulation of membrane protease activity
EJK50_RS08640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EJK50_RS08650	COG0425	Belongs to the sulfur carrier protein TusA family
EJK50_RS08660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EJK50_RS08665	COG1678	Uncharacterized ACR, COG1678
EJK50_RS08670	COG0497	DNA recombination
EJK50_RS08675	COG0242	peptide deformylase activity
EJK50_RS08680	COG0131	Imidazoleglycerol-phosphate dehydratase
EJK50_RS08685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EJK50_RS08745	COG1121	(ABC) transporter
EJK50_RS08750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EJK50_RS08755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EJK50_RS08760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EJK50_RS08765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EJK50_RS08790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EJK50_RS08795	COG0010	Belongs to the arginase family
EJK50_RS08800	COG2828	Protein conserved in bacteria
EJK50_RS08810	COG2813	Specifically methylates the guanine in position
EJK50_RS08840	COG0758	DNA mediated transformation
EJK50_RS08850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EJK50_RS08850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EJK50_RS08865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EJK50_RS08865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EJK50_RS08870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EJK50_RS08875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EJK50_RS08880	COG0706	membrane insertase activity
EJK50_RS08885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EJK50_RS08890	COG0594	ribonuclease P activity
EJK50_RS08895	COG0230	Belongs to the bacterial ribosomal protein bL34 family