locus-tag	class	description
MC49_RS00005	COG0754	glutathionylspermidine amidase activity
MC49_RS00010	COG2233	PERMEase
MC49_RS00020	COG1064	alcohol dehydrogenase
MC49_RS00055	COG0604	alcohol dehydrogenase
MC49_RS00060	COG1309	transcriptional regulator
MC49_RS00070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC49_RS00085	COG0640	Transcriptional regulator
MC49_RS00230	COG5484	DNA packaging
MC49_RS00230	COG3728	DNA packaging
MC49_RS00305	COG0305	Participates in initiation and elongation during chromosome replication
MC49_RS00420	COG0582	viral genome integration into host DNA
MC49_RS00430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MC49_RS00435	COG2501	S4 domain
MC49_RS00440	COG3038	cytochrome b561
MC49_RS00445	COG3783	Cytochrome b(562)
MC49_RS00455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MC49_RS00460	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC49_RS00465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MC49_RS00470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MC49_RS00480	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MC49_RS00485	COG4181	ATPase activity
MC49_RS00490	COG2755	lipolytic protein G-D-S-L family
MC49_RS00495	COG0300	oxidoreductase activity
MC49_RS00500	COG3118	belongs to the thioredoxin family
MC49_RS00505	COG0330	HflC and HflK could
MC49_RS00510	COG1585	Membrane protein implicated in regulation of membrane protease activity
MC49_RS00540	COG2217	Heavy metal translocating P-type atpase
MC49_RS00545	COG3735	TraB family
MC49_RS00550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC49_RS00570	COG0737	Belongs to the 5'-nucleotidase family
MC49_RS00575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC49_RS00575	COG4651	solute:proton antiporter activity
MC49_RS00580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS00585	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
MC49_RS00605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MC49_RS00610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MC49_RS00620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MC49_RS00635	COG1196	nuclear chromosome segregation
MC49_RS00635	COG3264	Mechanosensitive ion channel
MC49_RS00640	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MC49_RS00645	COG1309	transcriptional regulator
MC49_RS00650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC49_RS00655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC49_RS00680	COG1946	Acyl-CoA thioesterase
MC49_RS00685	COG0004	ammonium transporteR
MC49_RS00690	COG0347	Belongs to the P(II) protein family
MC49_RS00695	COG1132	(ABC) transporter
MC49_RS00700	COG1132	(ABC) transporter
MC49_RS00705	COG1522	sequence-specific DNA binding
MC49_RS00720	COG0824	Thioesterase
MC49_RS00725	COG1555	photosystem II stabilization
MC49_RS00730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC49_RS00740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MC49_RS00745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MC49_RS00750	COG0740	serine-type endopeptidase activity
MC49_RS00755	COG0544	peptidyl-prolyl cis-trans isomerase activity
MC49_RS00760	COG0271	Belongs to the BolA IbaG family
MC49_RS00765	COG3056	Lipoprotein
MC49_RS00770	COG2223	nitrite transmembrane transporter activity
MC49_RS00780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MC49_RS00785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MC49_RS00790	COG1845	cytochrome c oxidase, subunit III
MC49_RS00795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MC49_RS00800	COG0109	protoheme IX farnesyltransferase activity
MC49_RS00805	COG2814	Major facilitator Superfamily
MC49_RS00810	COG1666	GTP binding
MC49_RS00815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MC49_RS00820	COG0693	protein deglycase activity
MC49_RS00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC49_RS00830	COG0301	tRNA thio-modification
MC49_RS00840	COG0142	geranyltranstransferase activity
MC49_RS00845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MC49_RS00850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MC49_RS00855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC49_RS00860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MC49_RS00865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC49_RS00865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC49_RS00870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MC49_RS00875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC49_RS00880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC49_RS00885	COG1862	Preprotein translocase
MC49_RS00890	COG0343	queuine tRNA-ribosyltransferase activity
MC49_RS00895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MC49_RS00900	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
MC49_RS00905	COG0450	alkyl hydroperoxide reductase
MC49_RS00915	COG5002	protein histidine kinase activity
MC49_RS00920	COG0745	RESPONSE REGULATOR receiver
MC49_RS00925	COG0420	3'-5' exonuclease activity
MC49_RS00930	COG0419	ATPase involved in DNA repair
MC49_RS00940	COG1940	carbohydrate kinase activity
MC49_RS00945	COG2974	May be involved in recombination
MC49_RS00960	COG0425	Belongs to the sulfur carrier protein TusA family
MC49_RS00965	COG2391	methyltransferase activity
MC49_RS00970	COG0309	Hydrogenase expression formation protein (HypE)
MC49_RS00975	COG0409	Hydrogenase expression formation protein
MC49_RS00980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MC49_RS00985	COG1968	undecaprenyl-diphosphatase activity
MC49_RS00990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MC49_RS00995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MC49_RS01000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MC49_RS01005	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MC49_RS01010	COG0358	DNA primase activity
MC49_RS01065	COG3451	type IV secretory pathway VirB4
MC49_RS01075	COG3838	Conjugal transfer protein Trbc
MC49_RS01080	COG4962	Type ii secretion system protein e
MC49_RS01100	COG0583	DNA-binding transcription factor activity
MC49_RS01125	COG2076	Multidrug Resistance protein
MC49_RS01150	COG4959	Type IV secretory pathway protease TraF
MC49_RS01165	COG1192	Involved in chromosome partitioning
MC49_RS01200	COG1396	sequence-specific DNA binding
MC49_RS01205	COG5489	Protein of unknown function (DUF736)
MC49_RS01250	COG2003	Belongs to the UPF0758 family
MC49_RS01255	COG4804	nuclease activity
MC49_RS01270	COG0697	spore germination
MC49_RS01275	COG4953	penicillin-binding protein 1C
MC49_RS01280	COG2373	Large extracellular alpha-helical protein
MC49_RS01300	COG1773	rubredoxin
MC49_RS01305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MC49_RS01310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
MC49_RS01315	COG5557	Pfam Polysulphide reductase, NrfD
MC49_RS01320	COG0437	4 iron, 4 sulfur cluster binding
MC49_RS01325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MC49_RS01330	COG0733	neurotransmitter:sodium symporter activity
MC49_RS01345	COG2990	Protein conserved in bacteria
MC49_RS01350	COG0586	Pfam SNARE associated Golgi protein
MC49_RS01355	COG4575	ribosome binding
MC49_RS01360	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
MC49_RS01370	COG2259	Doxx family
MC49_RS01380	COG0583	DNA-binding transcription factor activity
MC49_RS01385	COG1741	Belongs to the pirin family
MC49_RS01395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MC49_RS01405	COG0792	nuclease activity
MC49_RS01410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MC49_RS01415	COG2823	Periplasmic or secreted lipoprotein
MC49_RS01420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC49_RS01425	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MC49_RS01430	COG5002	protein histidine kinase activity
MC49_RS01430	COG2198	Histidine kinase
MC49_RS01430	COG0784	Response regulator, receiver
MC49_RS01435	COG0070	glutamate synthase
MC49_RS01435	COG0067	glutamate synthase
MC49_RS01435	COG0069	glutamate synthase activity
MC49_RS01440	COG0493	'glutamate synthase
MC49_RS01445	COG2969	positive regulation of protein catabolic process
MC49_RS01450	COG0625	glutathione transferase activity
MC49_RS01455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MC49_RS01460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MC49_RS01465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MC49_RS01470	COG3105	Protein conserved in bacteria
MC49_RS01475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC49_RS01480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC49_RS01485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MC49_RS01490	COG4521	taurine ABC transporter
MC49_RS01495	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MC49_RS01500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC49_RS01505	COG2175	clavaminate synthase activity
MC49_RS01510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC49_RS01515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MC49_RS01520	COG5007	Belongs to the BolA IbaG family
MC49_RS01530	COG2854	intermembrane phospholipid transfer
MC49_RS01535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MC49_RS01540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MC49_RS01545	COG1127	ABC transporter
MC49_RS01555	COG0530	calcium, potassium:sodium antiporter activity
MC49_RS01560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MC49_RS01560	COG0517	IMP dehydrogenase activity
MC49_RS01565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MC49_RS01570	COG3117	lipopolysaccharide transmembrane transporter activity
MC49_RS01575	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MC49_RS01580	COG1137	ATPase activity
MC49_RS01585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MC49_RS01590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MC49_RS01600	COG1660	Displays ATPase and GTPase activities
MC49_RS01605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC49_RS01610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MC49_RS01625	COG0312	modulator of DNA gyrase
MC49_RS01630	COG3028	Belongs to the UPF0307 family
MC49_RS01635	COG2732	(Barnase) inhibitor
MC49_RS01640	COG4290	ribonuclease
MC49_RS01645	COG0312	modulator of DNA gyrase
MC49_RS01650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC49_RS01655	COG3164	Protein of unknown function
MC49_RS01670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MC49_RS01675	COG1792	Involved in formation and maintenance of cell shape
MC49_RS01680	COG1077	Cell shape determining protein MreB Mrl
MC49_RS01685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MC49_RS01690	COG0511	ligase activity, forming carbon-carbon bonds
MC49_RS01695	COG0439	Biotin carboxylase
MC49_RS01700	COG2264	protein methyltransferase activity
MC49_RS01705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC49_RS01710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MC49_RS01725	COG0477	Major facilitator Superfamily
MC49_RS01730	COG4774	siderophore transport
MC49_RS01735	COG0402	S-adenosylhomocysteine deaminase activity
MC49_RS01745	COG0840	transmembrane signaling receptor activity
MC49_RS01750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MC49_RS01755	COG0745	RESPONSE REGULATOR receiver
MC49_RS01760	COG2205	protein histidine kinase activity
MC49_RS01765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MC49_RS01785	COG0454	-acetyltransferase
MC49_RS01795	COG0410	ABC transporter
MC49_RS01800	COG0411	ABC transporter
MC49_RS01805	COG4177	L-phenylalanine transmembrane transporter activity
MC49_RS01810	COG0559	Belongs to the binding-protein-dependent transport system permease family
MC49_RS01825	COG1929	Belongs to the glycerate kinase type-1 family
MC49_RS01830	COG2610	gluconate transmembrane transporter activity
MC49_RS01835	COG3835	regulator
MC49_RS01850	COG2177	Part of the ABC transporter FtsEX involved in
MC49_RS01855	COG2884	Cell division ATP-binding protein ftsE
MC49_RS01860	COG0552	protein localization to endoplasmic reticulum
MC49_RS01860	COG0552	protein localization to endoplasmic reticulum
MC49_RS01865	COG0742	ribosomal rna small subunit methyltransferase
MC49_RS01870	COG3776	membrane
MC49_RS01880	COG3714	YhhN family
MC49_RS01890	COG3739	integral membrane protein
MC49_RS01895	COG0425	Belongs to the sulfur carrier protein TusA family
MC49_RS01900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MC49_RS01915	COG0247	lactate metabolic process
MC49_RS01925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MC49_RS01930	COG1053	succinate dehydrogenase
MC49_RS01935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MC49_RS01940	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MC49_RS01955	COG0298	carbon dioxide binding
MC49_RS01960	COG0375	protein maturation
MC49_RS01965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC49_RS01970	COG3604	Transcriptional regulator
MC49_RS02000	COG1966	Carbon starvation protein
MC49_RS02005	COG2879	small protein
MC49_RS02015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MC49_RS02025	COG3260	NADH ubiquinone oxidoreductase 20
MC49_RS02030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC49_RS02035	COG3261	NADH dehydrogenase
MC49_RS02035	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MC49_RS02040	COG0651	ATP synthesis coupled electron transport
MC49_RS02045	COG4237	Hydrogenase 4 membrane
MC49_RS02050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MC49_RS02055	COG0650	Formate hydrogenlyase subunit 4
MC49_RS02060	COG0651	ATP synthesis coupled electron transport
MC49_RS02065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC49_RS02070	COG2194	sulfuric ester hydrolase activity
MC49_RS02080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MC49_RS02090	COG2226	methyltransferase
MC49_RS02105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MC49_RS02110	COG1263	PTS System
MC49_RS02110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS02115	COG1737	Transcriptional regulator
MC49_RS02120	COG0459	protein refolding
MC49_RS02140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MC49_RS02145	COG1309	transcriptional regulator
MC49_RS02155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MC49_RS02205	COG3501	Rhs element vgr protein
MC49_RS02305	COG1396	sequence-specific DNA binding
MC49_RS02325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC49_RS02330	COG0601	transmembrane transport
MC49_RS02335	COG0747	negative chemotaxis
MC49_RS02340	COG2824	Alkylphosphonate utilization operon protein PhnA
MC49_RS02345	COG1396	sequence-specific DNA binding
MC49_RS02390	COG3121	Chaperone
MC49_RS02395	COG3188	usher protein
MC49_RS02410	COG0582	viral genome integration into host DNA
MC49_RS02435	COG3539	Fimbrial protein
MC49_RS02445	COG3188	usher protein
MC49_RS02455	COG3539	Fimbrial protein
MC49_RS02460	COG0582	viral genome integration into host DNA
MC49_RS02465	COG1957	nucleoside hydrolase
MC49_RS02470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MC49_RS02505	COG2137	regulation of response to DNA damage stimulus
MC49_RS02535	COG2992	FlgJ-related protein
MC49_RS02540	COG1696	Membrane protein involved in D-alanine export
MC49_RS02560	COG0531	amino acid
MC49_RS02570	COG0531	amino acid
MC49_RS02575	COG0124	histidyl-tRNA synthetase
MC49_RS02580	COG2188	Transcriptional regulator
MC49_RS02585	COG1397	ADP-ribosylglycohydrolase
MC49_RS02595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS02605	COG2610	gluconate transmembrane transporter activity
MC49_RS02610	COG3265	gluconokinase activity
MC49_RS02615	COG1609	Transcriptional regulator
MC49_RS02625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC49_RS02630	COG1120	ATPase activity
MC49_RS02635	COG0500	methyltransferase
MC49_RS02640	COG0157	Belongs to the NadC ModD family
MC49_RS02660	COG0789	Transcriptional regulator
MC49_RS02660	COG4978	Transcriptional regulator
MC49_RS02665	COG0668	transmembrane transport
MC49_RS02720	COG4790	Type iii secretion
MC49_RS02765	COG2207	Transcriptional regulator
MC49_RS02805	COG1396	sequence-specific DNA binding
MC49_RS02810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MC49_RS02815	COG1177	transmembrane transport
MC49_RS02845	COG2814	Major facilitator Superfamily
MC49_RS02880	COG2373	Large extracellular alpha-helical protein
MC49_RS02880	COG1388	LysM domain
MC49_RS02880	COG4932	domain protein
MC49_RS02890	COG4932	domain protein
MC49_RS02890	COG2373	Large extracellular alpha-helical protein
MC49_RS02890	COG1388	LysM domain
MC49_RS02905	COG0584	glycerophosphoryl diester phosphodiesterase
MC49_RS02910	COG2197	response regulator
MC49_RS02915	COG3850	Histidine kinase
MC49_RS02920	COG2223	nitrite transmembrane transporter activity
MC49_RS02925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MC49_RS02935	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MC49_RS02940	COG2181	nitrate reductase activity
MC49_RS02955	COG1280	lysine exporter protein (LysE YggA)
MC49_RS02995	COG1473	amidohydrolase
MC49_RS03015	COG3188	usher protein
MC49_RS03050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS03065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC49_RS03100	COG3727	T/G mismatch-specific endonuclease activity
MC49_RS03105	COG2378	regulation of single-species biofilm formation
MC49_RS03110	COG0625	glutathione transferase activity
MC49_RS03120	COG1396	sequence-specific DNA binding
MC49_RS03125	COG3468	outer membrane autotransporter barrel domain protein
MC49_RS03180	COG0582	viral genome integration into host DNA
MC49_RS03190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC49_RS03195	COG1690	Belongs to the RtcB family
MC49_RS03200	COG4650	regulator
MC49_RS03205	COG0795	lipopolysaccharide-transporting ATPase activity
MC49_RS03210	COG0795	lipopolysaccharide-transporting ATPase activity
MC49_RS03215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MC49_RS03220	COG2927	DNA polymerase III (CHI subunit)
MC49_RS03225	COG0525	valine-tRNA ligase activity
MC49_RS03230	COG0456	acetyltransferase
MC49_RS03235	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
MC49_RS03240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MC49_RS03245	COG0540	Belongs to the ATCase OTCase family
MC49_RS03250	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MC49_RS03260	COG1309	transcriptional regulator
MC49_RS03270	COG1328	CTP reductase activity
MC49_RS03275	COG0602	queuosine metabolic process
MC49_RS03280	COG3787	Belongs to the UPF0306 family
MC49_RS03295	COG3153	acetyltransferase
MC49_RS03300	COG3154	lipid carrier protein
MC49_RS03305	COG0826	peptidase U32
MC49_RS03310	COG0826	peptidase U32
MC49_RS03335	COG3275	phosphorelay sensor kinase activity
MC49_RS03345	COG0513	Belongs to the DEAD box helicase family
MC49_RS03360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MC49_RS03365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MC49_RS03370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MC49_RS03375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MC49_RS03380	COG0195	Participates in both transcription termination and antitermination
MC49_RS03400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MC49_RS03405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC49_RS03410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MC49_RS03415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MC49_RS03420	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MC49_RS03425	COG1534	Rna-binding protein
MC49_RS03435	COG2027	D-alanyl-D-alanine carboxypeptidase
MC49_RS03440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MC49_RS03445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MC49_RS03450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MC49_RS03455	COG0142	geranyltranstransferase activity
MC49_RS03465	COG3423	Transcriptional regulator
MC49_RS03470	COG0039	L-malate dehydrogenase activity
MC49_RS03475	COG1438	arginine binding
MC49_RS03480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MC49_RS03485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MC49_RS03495	COG2105	PFAM AIG2 family protein
MC49_RS03505	COG0729	surface antigen
MC49_RS03510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC49_RS03515	COG1253	flavin adenine dinucleotide binding
MC49_RS03525	COG1218	3'(2'),5'-bisphosphate nucleotidase
MC49_RS03530	COG0545	Peptidyl-prolyl cis-trans isomerase
MC49_RS03540	COG0359	binds to the 23S rRNA
MC49_RS03545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MC49_RS03550	COG2965	DNA replication, synthesis of RNA primer
MC49_RS03555	COG0360	Binds together with S18 to 16S ribosomal RNA
MC49_RS03560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC49_RS03565	COG0557	exoribonuclease II activity
MC49_RS03570	COG1959	2 iron, 2 sulfur cluster binding
MC49_RS03575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MC49_RS03580	COG0330	HflC and HflK could
MC49_RS03585	COG0330	HflC and HflK could
MC49_RS03590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MC49_RS03595	COG1923	regulation of RNA biosynthetic process
MC49_RS03605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MC49_RS03610	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC49_RS03615	COG0802	atpase or kinase
MC49_RS03620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MC49_RS03645	COG1162	GTPase activity
MC49_RS03650	COG0688	phosphatidylethanolamine metabolic process
MC49_RS03655	COG1511	domain protein
MC49_RS03655	COG3264	Mechanosensitive ion channel
MC49_RS03665	COG0814	amino acid
MC49_RS03670	COG0561	phosphatase activity
MC49_RS03675	COG2267	carboxylic ester hydrolase activity
MC49_RS03680	COG0514	ATP-dependent DNA helicase (RecQ)
MC49_RS03685	COG2962	Rard protein
MC49_RS03700	COG0210	DNA helicase
MC49_RS03705	COG1011	Hydrolase
MC49_RS03720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MC49_RS03730	COG1965	Belongs to the frataxin family
MC49_RS03745	COG1587	Uroporphyrinogen-III synthase
MC49_RS03750	COG2959	enzyme of heme biosynthesis
MC49_RS03755	COG3071	HemY protein
MC49_RS03780	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MC49_RS03790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MC49_RS03795	COG2244	polysaccharide biosynthetic process
MC49_RS03800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MC49_RS03805	COG0456	acetyltransferase
MC49_RS03810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MC49_RS03815	COG1088	dTDP-glucose 4,6-dehydratase activity
MC49_RS03820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MC49_RS03825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MC49_RS03830	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
MC49_RS03835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MC49_RS03840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MC49_RS03845	COG3118	belongs to the thioredoxin family
MC49_RS03850	COG0513	Belongs to the DEAD box helicase family
MC49_RS03855	COG0248	Ppx GppA phosphatase
MC49_RS03860	COG0210	DNA helicase
MC49_RS03875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MC49_RS03885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC49_RS03890	COG0129	dihydroxy-acid dehydratase activity
MC49_RS03900	COG3978	acetolactate synthase activity
MC49_RS03920	COG3085	chromosome segregation
MC49_RS03925	COG0583	DNA-binding transcription factor activity
MC49_RS03965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MC49_RS03980	COG0009	L-threonylcarbamoyladenylate synthase
MC49_RS03985	COG0551	DNA topoisomerase type I activity
MC49_RS03990	COG0758	DNA mediated transformation
MC49_RS03995	COG0242	peptide deformylase activity
MC49_RS04000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC49_RS04005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MC49_RS04005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC49_RS04010	COG0569	domain protein
MC49_RS04020	COG3036	rescue of stalled ribosome
MC49_RS04025	COG0789	Transcriptional regulator
MC49_RS04040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MC49_RS04045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MC49_RS04050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MC49_RS04055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MC49_RS04060	COG0201	protein transport
MC49_RS04065	COG0200	Binds to the 23S rRNA
MC49_RS04070	COG1841	ribosomal large subunit assembly
MC49_RS04075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MC49_RS04085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MC49_RS04090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MC49_RS04095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MC49_RS04105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MC49_RS04110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MC49_RS04115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MC49_RS04120	COG0255	Belongs to the universal ribosomal protein uL29 family
MC49_RS04125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MC49_RS04130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MC49_RS04135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MC49_RS04140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MC49_RS04145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MC49_RS04160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MC49_RS04165	COG0051	transcription antitermination factor activity, RNA binding
MC49_RS04205	COG1072	(Pantothenic acid kinase))
MC49_RS04215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MC49_RS04250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MC49_RS04255	COG4206	TonB-dependent receptor
MC49_RS04260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC49_RS04265	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
MC49_RS04270	COG0310	cobalt ion transport
MC49_RS04275	COG0310	cobalt ion transport
MC49_RS04285	COG1122	ATPase activity
MC49_RS04290	COG2252	PERMEase
MC49_RS04295	COG0765	amino acid transport
MC49_RS04300	COG0765	amino acid transport
MC49_RS04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC49_RS04315	COG3121	Chaperone
MC49_RS04320	COG3188	usher protein
MC49_RS04340	COG0704	Plays a role in the regulation of phosphate uptake
MC49_RS04350	COG0581	inorganic phosphate transmembrane transporter activity
MC49_RS04355	COG0573	inorganic phosphate transmembrane transporter activity
MC49_RS04360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MC49_RS04375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MC49_RS04380	COG2183	response to ionizing radiation
MC49_RS04385	COG1918	ferrous iron import across plasma membrane
MC49_RS04400	COG0596	Alpha beta hydrolase
MC49_RS04405	COG1040	competence protein
MC49_RS04410	COG0316	Belongs to the HesB IscA family
MC49_RS04410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MC49_RS04415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC49_RS04420	COG0705	Rhomboid family
MC49_RS04425	COG1349	DNA-binding transcription factor activity
MC49_RS04430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MC49_RS04445	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MC49_RS04450	COG0028	Belongs to the TPP enzyme family
MC49_RS04455	COG1473	amidohydrolase
MC49_RS04460	COG0583	DNA-binding transcription factor activity
MC49_RS04465	COG1396	sequence-specific DNA binding
MC49_RS04470	COG0477	Major facilitator Superfamily
MC49_RS04490	COG0814	amino acid
MC49_RS04500	COG1396	sequence-specific DNA binding
MC49_RS04505	COG0183	Belongs to the thiolase family
MC49_RS04510	COG2031	fatty acid transporter
MC49_RS04515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MC49_RS04520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MC49_RS04525	COG2204	response regulator
MC49_RS04530	COG3852	Histidine kinase
MC49_RS04535	COG0800	Aldolase
MC49_RS04540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS04545	COG1904	glucuronate isomerase
MC49_RS04550	COG0246	Mannitol dehydrogenase
MC49_RS04565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MC49_RS04575	COG2186	Transcriptional regulator
MC49_RS04580	COG0626	cystathionine gamma-synthase activity
MC49_RS04585	COG1757	Na H antiporter
MC49_RS04590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MC49_RS04605	COG3188	usher protein
MC49_RS04620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC49_RS04625	COG3162	membrane
MC49_RS04630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC49_RS04635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC49_RS04640	COG2258	MOSC domain
MC49_RS04650	COG3381	protein complex oligomerization
MC49_RS04655	COG3302	dmso reductase anchor subunit
MC49_RS04660	COG0437	4 iron, 4 sulfur cluster binding
MC49_RS04665	COG0243	molybdopterin cofactor binding
MC49_RS04675	COG0180	Tryptophanyl-tRNA synthetase
MC49_RS04680	COG0546	phosphoglycolate phosphatase activity
MC49_RS04685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MC49_RS04695	COG3266	domain, Protein
MC49_RS04700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MC49_RS04710	COG4796	Type ii and iii secretion system protein
MC49_RS04730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MC49_RS04735	COG0494	nUDIX hydrolase
MC49_RS04745	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MC49_RS04750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MC49_RS04755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MC49_RS04760	COG1741	Belongs to the pirin family
MC49_RS04770	COG2081	HI0933 family
MC49_RS04775	COG0306	phosphate transporter
MC49_RS04785	COG0589	response to stress
MC49_RS04790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC49_RS04795	COG0742	ribosomal rna small subunit methyltransferase
MC49_RS04810	COG0582	viral genome integration into host DNA
MC49_RS04855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC49_RS04875	COG4735	regulation of single-species biofilm formation
MC49_RS04880	COG2378	regulation of single-species biofilm formation
MC49_RS04965	COG0786	glutamate:sodium symporter activity
MC49_RS04980	COG0640	Transcriptional regulator
MC49_RS05020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
MC49_RS05025	COG3683	transport system, periplasmic component
MC49_RS05030	COG0840	transmembrane signaling receptor activity
MC49_RS05035	COG0625	glutathione transferase activity
MC49_RS05060	COG2186	Transcriptional regulator
MC49_RS05065	COG0477	Major facilitator Superfamily
MC49_RS05070	COG1609	Transcriptional regulator
MC49_RS05075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS05080	COG1879	ABC-type sugar transport system periplasmic component
MC49_RS05085	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC49_RS05090	COG1129	ABC transporter
MC49_RS05095	COG1869	D-ribose catabolic process
MC49_RS05100	COG3397	chitin binding
MC49_RS05110	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MC49_RS05115	COG2502	aspartate--ammonia ligase
MC49_RS05120	COG1522	sequence-specific DNA binding
MC49_RS05125	COG0716	FMN binding
MC49_RS05130	COG0445	tRNA wobble uridine modification
MC49_RS05135	COG0357	Ribosomal RNA small subunit methyltransferase G
MC49_RS05140	COG3312	ion transport
MC49_RS05145	COG0356	it plays a direct role in the translocation of protons across the membrane
MC49_RS05155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MC49_RS05160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MC49_RS05165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MC49_RS05170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MC49_RS05175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MC49_RS05180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MC49_RS05185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MC49_RS05190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MC49_RS05240	COG0732	type I restriction modification DNA specificity domain
MC49_RS05255	COG0840	transmembrane signaling receptor activity
MC49_RS05260	COG0840	transmembrane signaling receptor activity
MC49_RS05275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC49_RS05295	COG0076	glutamate decarboxylase activity
MC49_RS05300	COG0531	amino acid
MC49_RS05305	COG2066	Belongs to the glutaminase family
MC49_RS05310	COG0531	amino acid
MC49_RS05325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MC49_RS05350	COG0594	ribonuclease P activity
MC49_RS05355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MC49_RS05360	COG0706	membrane insertase activity
MC49_RS05365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MC49_RS05370	COG0697	spore germination
MC49_RS05380	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MC49_RS05410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MC49_RS05415	COG0243	molybdopterin cofactor binding
MC49_RS05415	COG3383	formate dehydrogenase (NAD+) activity
MC49_RS05420	COG0243	molybdopterin cofactor binding
MC49_RS05420	COG3383	formate dehydrogenase (NAD+) activity
MC49_RS05425	COG0437	4 iron, 4 sulfur cluster binding
MC49_RS05430	COG2864	formate dehydrogenase
MC49_RS05435	COG3058	Necessary for formate dehydrogenase activity
MC49_RS05440	COG1921	L-seryl-tRNASec selenium transferase activity
MC49_RS05445	COG3276	selenocysteine insertion sequence binding
MC49_RS05480	COG0583	DNA-binding transcription factor activity
MC49_RS05495	COG1275	C4-dicarboxylate transporter malic acid transport protein
MC49_RS05500	COG2233	PERMEase
MC49_RS05515	COG1561	YicC-like family, N-terminal region
MC49_RS05520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MC49_RS05525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MC49_RS05530	COG1309	transcriptional regulator
MC49_RS05535	COG0756	dUTP diphosphatase activity
MC49_RS05540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC49_RS05545	COG2003	Belongs to the UPF0758 family
MC49_RS05555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MC49_RS05560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MC49_RS05565	COG1216	Glycosyl transferase, family 2
MC49_RS05575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MC49_RS05580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MC49_RS05590	COG1519	Transferase
MC49_RS05595	COG0859	PFAM glycosyl transferase family 9
MC49_RS05615	COG0859	PFAM glycosyl transferase family 9
MC49_RS05625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC49_RS05635	COG2861	carbohydrate metabolic process
MC49_RS05640	COG4942	peptidase
MC49_RS05645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC49_RS05650	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MC49_RS05655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MC49_RS05660	COG1045	serine acetyltransferase
MC49_RS05665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MC49_RS05675	COG0367	asparagine synthase
MC49_RS05680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MC49_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
MC49_RS05720	COG1083	cytidylyl-transferase
MC49_RS05725	COG0673	inositol 2-dehydrogenase activity
MC49_RS05735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MC49_RS05740	COG2089	acid synthase
MC49_RS05745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MC49_RS05750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MC49_RS05770	COG2205	protein histidine kinase activity
MC49_RS05775	COG0745	RESPONSE REGULATOR receiver
MC49_RS05790	COG0205	6-phosphofructokinase activity
MC49_RS05800	COG0149	triose-phosphate isomerase activity
MC49_RS05810	COG3152	Membrane
MC49_RS05820	COG2814	Major facilitator Superfamily
MC49_RS05825	COG0584	glycerophosphoryl diester phosphodiesterase
MC49_RS05830	COG2271	Major facilitator Superfamily
MC49_RS05835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MC49_RS05845	COG3074	FtsZ-dependent cytokinesis
MC49_RS05850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MC49_RS05855	COG1575	Belongs to the MenA family. Type 1 subfamily
MC49_RS05860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MC49_RS05865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MC49_RS05870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MC49_RS05875	COG1609	Transcriptional regulator
MC49_RS05880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MC49_RS05895	COG0626	cystathionine gamma-synthase activity
MC49_RS05900	COG0527	aspartate kinase activity
MC49_RS05900	COG0460	homoserine dehydrogenase
MC49_RS05905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MC49_RS05925	COG3468	outer membrane autotransporter barrel domain protein
MC49_RS05935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC49_RS05940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MC49_RS05945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MC49_RS05950	COG0137	argininosuccinate synthase activity
MC49_RS05955	COG0165	Argininosuccinate lyase
MC49_RS05965	COG0583	DNA-binding transcription factor activity
MC49_RS05970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC49_RS05995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC49_RS06015	COG1217	gtp-binding protein TYPA
MC49_RS06020	COG1011	Hydrolase
MC49_RS06030	COG0456	acetyltransferase
MC49_RS06035	COG2982	Protein involved in outer membrane biogenesis
MC49_RS06040	COG2233	PERMEase
MC49_RS06045	COG0786	glutamate:sodium symporter activity
MC49_RS06050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MC49_RS06055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC49_RS06060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MC49_RS06065	COG1758	RNA polymerase activity
MC49_RS06080	COG2860	membrane
MC49_RS06085	COG0823	Involved in the tonB-independent uptake of proteins
MC49_RS06090	COG5645	(Lipo)protein
MC49_RS06095	COG2818	Glycosylase
MC49_RS06125	COG0747	negative chemotaxis
MC49_RS06130	COG0601	transmembrane transport
MC49_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC49_RS06140	COG0444	Belongs to the ABC transporter superfamily
MC49_RS06145	COG4608	Belongs to the ABC transporter superfamily
MC49_RS06150	COG2199	diguanylate cyclase activity
MC49_RS06150	COG2200	EAL domain
MC49_RS06165	COG1942	4-Oxalocrotonate Tautomerase
MC49_RS06170	COG1295	ribonuclease BN
MC49_RS06180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MC49_RS06185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC49_RS06200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MC49_RS06210	COG0746	molybdenum cofactor guanylyltransferase activity
MC49_RS06215	COG3084	Protein conserved in bacteria
MC49_RS06220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MC49_RS06225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MC49_RS06230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC49_RS06230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC49_RS06245	COG0242	peptide deformylase activity
MC49_RS06250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MC49_RS06255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MC49_RS06265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MC49_RS06275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC49_RS06280	COG1765	OsmC-like protein
MC49_RS06285	COG3954	Phosphoribulokinase
MC49_RS06290	COG3089	Belongs to the UPF0270 family
MC49_RS06295	COG0429	hydrolase of the alpha beta-hydrolase fold
MC49_RS06305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS06305	COG1263	PTS System
MC49_RS06310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MC49_RS06320	COG0488	(ABC) transporter
MC49_RS06325	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC49_RS06335	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
MC49_RS06340	COG1047	Peptidyl-prolyl cis-trans
MC49_RS06345	COG2900	Belongs to the SlyX family
MC49_RS06350	COG0545	Peptidyl-prolyl cis-trans isomerase
MC49_RS06355	COG2964	Protein conserved in bacteria
MC49_RS06375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MC49_RS06380	COG0049	tRNA binding
MC49_RS06385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MC49_RS06400	COG0250	Participates in transcription elongation, termination and antitermination
MC49_RS06405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MC49_RS06410	COG0081	regulation of translation
MC49_RS06415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MC49_RS06425	COG0085	RNA polymerase activity
MC49_RS06430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MC49_RS06435	COG0726	polysaccharide deacetylase
MC49_RS06445	COG0626	cystathionine gamma-synthase activity
MC49_RS06450	COG1115	amino acid carrier protein
MC49_RS06455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MC49_RS06460	COG2022	thiamine diphosphate biosynthetic process
MC49_RS06465	COG2104	thiamine diphosphate biosynthetic process
MC49_RS06470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC49_RS06475	COG0352	thiamine-phosphate diphosphorylase activity
MC49_RS06480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MC49_RS06485	COG0840	transmembrane signaling receptor activity
MC49_RS06495	COG3842	ATPase activity
MC49_RS06520	COG2816	NAD+ diphosphatase activity
MC49_RS06525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MC49_RS06530	COG1515	deoxyribonuclease V activity
MC49_RS06535	COG3068	Protein conserved in bacteria
MC49_RS06550	COG0151	Belongs to the GarS family
MC49_RS06590	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MC49_RS06595	COG0800	Aldolase
MC49_RS06600	COG0129	dihydroxy-acid dehydratase activity
MC49_RS06605	COG1410	methionine synthase
MC49_RS06605	COG0646	methionine synthase
MC49_RS06620	COG0527	aspartate kinase activity
MC49_RS06635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MC49_RS06640	COG2937	Belongs to the GPAT DAPAT family
MC49_RS06645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MC49_RS06650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MC49_RS06655	COG0735	belongs to the Fur family
MC49_RS06660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC49_RS06665	COG1396	sequence-specific DNA binding
MC49_RS06695	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MC49_RS06705	COG5532	Uncharacterized conserved protein (DUF2303)
MC49_RS06790	COG1403	HNH endonuclease
MC49_RS06815	COG3772	lysozyme
MC49_RS06855	COG0740	serine-type endopeptidase activity
MC49_RS06970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC49_RS06995	COG1448	Aminotransferase
MC49_RS07000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MC49_RS07010	COG0629	single-stranded DNA binding
MC49_RS07020	COG0028	Belongs to the TPP enzyme family
MC49_RS07025	COG0440	acetolactate synthase activity
MC49_RS07045	COG2252	PERMEase
MC49_RS07050	COG0025	NhaP-type Na H and K H
MC49_RS07060	COG0583	DNA-binding transcription factor activity
MC49_RS07065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MC49_RS07070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MC49_RS07075	COG1690	Belongs to the RtcB family
MC49_RS07085	COG2365	Tyrosine phosphatase family
MC49_RS07090	COG0586	Pfam SNARE associated Golgi protein
MC49_RS07095	COG1322	Protein conserved in bacteria
MC49_RS07100	COG2226	methyltransferase
MC49_RS07110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MC49_RS07115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MC49_RS07120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MC49_RS07125	COG0805	protein transport
MC49_RS07140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MC49_RS07150	COG0183	Belongs to the thiolase family
MC49_RS07160	COG0006	proline dipeptidase activity
MC49_RS07165	COG1739	Uncharacterized protein family UPF0029
MC49_RS07170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC49_RS07175	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MC49_RS07215	COG1472	Belongs to the glycosyl hydrolase 3 family
MC49_RS07225	COG0583	DNA-binding transcription factor activity
MC49_RS07230	COG1124	(ABC) transporter
MC49_RS07275	COG2813	Specifically methylates the guanine in position
MC49_RS07280	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
MC49_RS07295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MC49_RS07305	COG4667	esterase of the alpha-beta hydrolase superfamily
MC49_RS07310	COG0084	hydrolase, TatD family'
MC49_RS07315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC49_RS07320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MC49_RS07325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MC49_RS07330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MC49_RS07340	COG0612	Peptidase, M16
MC49_RS07345	COG4178	(ABC) transporter
MC49_RS07350	COG4771	TonB-dependent receptor
MC49_RS07360	COG1595	DNA-templated transcription, initiation
MC49_RS07380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC49_RS07385	COG4172	Belongs to the ABC transporter superfamily
MC49_RS07395	COG0832	Belongs to the urease beta subunit family
MC49_RS07400	COG0804	urea catabolic process
MC49_RS07415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MC49_RS07425	COG4413	Urea transporter
MC49_RS07430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC49_RS07435	COG1289	transmembrane transporter activity
MC49_RS07440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MC49_RS07445	COG3726	membrane protein affecting hemolysin expression
MC49_RS07450	COG0560	Phosphoserine phosphatase
MC49_RS07455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MC49_RS07465	COG0488	(ABC) transporter
MC49_RS07475	COG0741	lytic transglycosylase activity
MC49_RS07480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
MC49_RS07495	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MC49_RS07500	COG0406	alpha-ribazole phosphatase activity
MC49_RS07505	COG2207	Transcriptional regulator
MC49_RS07505	COG3708	Transcriptional regulator
MC49_RS07510	COG3045	CreA protein
MC49_RS07515	COG0745	RESPONSE REGULATOR receiver
MC49_RS07530	COG0083	homoserine kinase activity
MC49_RS07550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MC49_RS07555	COG0521	Mo-molybdopterin cofactor biosynthetic process
MC49_RS07570	COG0443	Heat shock 70 kDa protein
MC49_RS07575	COG0484	heat shock protein binding
MC49_RS07585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MC49_RS07590	COG0583	DNA-binding transcription factor activity
MC49_RS07595	COG0268	Binds directly to 16S ribosomal RNA
MC49_RS07600	COG0196	riboflavin kinase activity
MC49_RS07605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MC49_RS07610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MC49_RS07615	COG1047	Peptidyl-prolyl cis-trans
MC49_RS07620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MC49_RS07635	COG0505	Belongs to the CarA family
MC49_RS07645	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MC49_RS07645	COG5295	Hep Hag repeat protein
MC49_RS07655	COG1979	alcohol dehydrogenase
MC49_RS07660	COG0586	Pfam SNARE associated Golgi protein
MC49_RS07670	COG0848	biopolymer transport protein
MC49_RS07680	COG4991	sh3 domain protein
MC49_RS07685	COG3025	triphosphatase activity
MC49_RS07690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MC49_RS07695	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MC49_RS07695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MC49_RS07705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC49_RS07710	COG3384	dioxygenase
MC49_RS07715	COG0754	glutathionylspermidine amidase activity
MC49_RS07730	COG0494	nUDIX hydrolase
MC49_RS07735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MC49_RS07740	COG3150	esterase
MC49_RS07755	COG0204	Acyl-transferase
MC49_RS07760	COG2132	Multicopper oxidase
MC49_RS07770	COG1280	lysine exporter protein (LysE YggA)
MC49_RS07780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MC49_RS07790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MC49_RS07795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MC49_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC49_RS07805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MC49_RS07810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MC49_RS07815	COG0564	pseudouridine synthase activity
MC49_RS07820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC49_RS07825	COG0417	DNA replication proofreading
MC49_RS07830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MC49_RS07835	COG1178	ABC-type Fe3 transport system permease component
MC49_RS07840	COG4143	(ABC) transporter
MC49_RS07845	COG0494	nUDIX hydrolase
MC49_RS07855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MC49_RS07860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MC49_RS07870	COG4795	General secretion pathway protein
MC49_RS07885	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MC49_RS07895	COG1074	ATP-dependent DNA helicase activity
MC49_RS07900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MC49_RS07905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MC49_RS07905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MC49_RS07910	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC49_RS07930	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MC49_RS07935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MC49_RS07940	COG2166	iron-sulfur cluster assembly
MC49_RS07945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MC49_RS07950	COG0583	DNA-binding transcription factor activity
MC49_RS07955	COG2363	Small membrane protein
MC49_RS07970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC49_RS07975	COG1611	Belongs to the LOG family
MC49_RS07990	COG3098	single-species biofilm formation
MC49_RS07995	COG0564	pseudouridine synthase activity
MC49_RS08000	COG0716	FMN binding
MC49_RS08015	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MC49_RS08030	COG0052	Belongs to the universal ribosomal protein uS2 family
MC49_RS08035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MC49_RS08040	COG0528	UMP kinase activity
MC49_RS08045	COG0233	cytoplasmic translational termination
MC49_RS08055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MC49_RS08060	COG0575	Belongs to the CDS family
MC49_RS08070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC49_RS08080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC49_RS08085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC49_RS08090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC49_RS08095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MC49_RS08100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MC49_RS08110	COG0825	malonyl-CoA metabolic process
MC49_RS08115	COG0037	tRNA processing
MC49_RS08120	COG4568	rho-dependent transcription termination
MC49_RS08125	COG3015	lipoprotein NlpE involved in copper resistance
MC49_RS08130	COG0442	prolyl-tRNA aminoacylation
MC49_RS08135	COG1720	tRNA m6t6A37 methyltransferase activity
MC49_RS08145	COG1464	Belongs to the NlpA lipoprotein family
MC49_RS08155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MC49_RS08160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MC49_RS08185	COG3021	interspecies interaction between organisms
MC49_RS08205	COG0602	queuosine metabolic process
MC49_RS08210	COG0720	synthase
MC49_RS08215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MC49_RS08225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MC49_RS08230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MC49_RS08235	COG0585	pseudouridine synthase activity
MC49_RS08245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MC49_RS08250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MC49_RS08255	COG1388	LysM domain
MC49_RS08255	COG4942	peptidase
MC49_RS08265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MC49_RS08300	COG0471	metal ion transport
MC49_RS08330	COG1301	dicarboxylic acid transport
MC49_RS08335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MC49_RS08335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MC49_RS08345	COG0501	Belongs to the peptidase M48B family
MC49_RS08350	COG0583	DNA-binding transcription factor activity
MC49_RS08360	COG0588	phosphoglycerate mutase activity
MC49_RS08370	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
MC49_RS08375	COG1492	cobalamin metabolic process
MC49_RS08440	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MC49_RS08460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC49_RS08460	COG1648	precorrin-2 dehydrogenase activity
MC49_RS08475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC49_RS08475	COG1648	precorrin-2 dehydrogenase activity
MC49_RS08480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MC49_RS08490	COG4865	methylaspartate mutase activity
MC49_RS08495	COG3799	methylaspartate ammonia-lyase activity
MC49_RS08510	COG1301	dicarboxylic acid transport
MC49_RS08520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC49_RS08530	COG1082	Xylose isomerase domain protein TIM barrel
MC49_RS08535	COG2188	Transcriptional regulator
MC49_RS08545	COG4810	utilization protein
MC49_RS08550	COG4917	ethanolamine utilization protein
MC49_RS08560	COG4812	Cobalamin adenosyltransferase
MC49_RS08565	COG0280	phosphate acetyltransferase
MC49_RS08575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
MC49_RS08585	COG4820	ethanolamine utilization protein (EutJ)
MC49_RS08600	COG4819	ethanolamine utilization protein
MC49_RS08605	COG4303	Ethanolamine ammonia lyase large subunit
MC49_RS08615	COG4816	utilization protein
MC49_RS08620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MC49_RS08625	COG4656	Part of a membrane complex involved in electron transport
MC49_RS08640	COG0252	asparaginase activity
MC49_RS08645	COG4206	TonB-dependent receptor
MC49_RS08675	COG2252	PERMEase
MC49_RS08680	COG0402	S-adenosylhomocysteine deaminase activity
MC49_RS08685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MC49_RS08685	COG2080	2 iron, 2 sulfur cluster binding
MC49_RS08690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MC49_RS08695	COG0402	S-adenosylhomocysteine deaminase activity
MC49_RS08700	COG0493	'glutamate synthase
MC49_RS08700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC49_RS08705	COG2068	MobA-Related Protein
MC49_RS08710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MC49_RS08715	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MC49_RS08715	COG3608	succinylglutamate desuccinylase aspartoacylase
MC49_RS08720	COG1914	H( )-stimulated, divalent metal cation uptake system
MC49_RS08730	COG0668	transmembrane transport
MC49_RS08755	COG0477	Major facilitator Superfamily
MC49_RS08765	COG0549	Belongs to the carbamate kinase family
MC49_RS08775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC49_RS08780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC49_RS08785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MC49_RS08790	COG3829	transcription factor binding
MC49_RS08800	COG1733	regulation of RNA biosynthetic process
MC49_RS08805	COG2080	2 iron, 2 sulfur cluster binding
MC49_RS08810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MC49_RS08815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MC49_RS08830	COG4566	intracellular signal transduction
MC49_RS08840	COG2962	Rard protein
MC49_RS08860	COG1966	Carbon starvation protein
MC49_RS08865	COG0523	cobalamin synthesis protein
MC49_RS08875	COG0534	Mate efflux family protein
MC49_RS08880	COG0673	inositol 2-dehydrogenase activity
MC49_RS08895	COG3033	Beta-eliminating lyase
MC49_RS08900	COG0814	amino acid
MC49_RS08905	COG5564	TIM-barrel signal transduction protein
MC49_RS08910	COG5441	Belongs to the UPF0261 family
MC49_RS08935	COG3842	ATPase activity
MC49_RS08945	COG1840	ABC-type Fe3 transport system, periplasmic component
MC49_RS08950	COG2271	Major facilitator Superfamily
MC49_RS08980	COG0288	reversible hydration of carbon dioxide
MC49_RS08985	COG1131	(ABC) transporter
MC49_RS08990	COG0842	Transport permease protein
MC49_RS09020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MC49_RS09025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MC49_RS09045	COG1489	DNA binding
MC49_RS09050	COG1643	Atp-dependent helicase
MC49_RS09055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC49_RS09065	COG2864	formate dehydrogenase
MC49_RS09070	COG0437	4 iron, 4 sulfur cluster binding
MC49_RS09085	COG0243	molybdopterin cofactor binding
MC49_RS09090	COG0437	4 iron, 4 sulfur cluster binding
MC49_RS09100	COG3381	protein complex oligomerization
MC49_RS09110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MC49_RS09115	COG0316	Belongs to the HesB IscA family
MC49_RS09140	COG0437	4 iron, 4 sulfur cluster binding
MC49_RS09160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC49_RS09165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MC49_RS09175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC49_RS09180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MC49_RS09185	COG3956	TIGRFAM MazG family protein
MC49_RS09190	COG0504	CTP synthase activity
MC49_RS09195	COG0148	phosphopyruvate hydratase activity
MC49_RS09200	COG0471	metal ion transport
MC49_RS09205	COG1388	LysM domain
MC49_RS09205	COG0741	lytic transglycosylase activity
MC49_RS09210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC49_RS09215	COG2226	methyltransferase
MC49_RS09220	COG0328	RNA-DNA hybrid ribonuclease activity
MC49_RS09225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC49_RS09240	COG2233	PERMEase
MC49_RS09245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MC49_RS09250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC49_RS09275	COG1358	cellular component organization or biogenesis
MC49_RS09335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MC49_RS09345	COG1846	Transcriptional regulator
MC49_RS09350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC49_RS09370	COG1349	DNA-binding transcription factor activity
MC49_RS09375	COG0561	phosphatase activity
MC49_RS09380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MC49_RS09390	COG1304	FMN binding
MC49_RS09395	COG1620	l-lactate permease
MC49_RS09430	COG2211	Major facilitator Superfamily
MC49_RS09435	COG0583	DNA-binding transcription factor activity
MC49_RS09485	COG1840	ABC-type Fe3 transport system, periplasmic component
MC49_RS09490	COG0395	ABC-type sugar transport system, permease component
MC49_RS09495	COG3842	ATPase activity
MC49_RS09505	COG0500	methyltransferase
MC49_RS09510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MC49_RS09515	COG1737	Transcriptional regulator
MC49_RS09520	COG2731	YhcH YjgK YiaL family protein
MC49_RS09525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC49_RS09535	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MC49_RS09540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MC49_RS09550	COG0582	viral genome integration into host DNA
MC49_RS09560	COG0741	lytic transglycosylase activity
MC49_RS09565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MC49_RS09570	COG1194	a g-specific adenine glycosylase
MC49_RS09580	COG3171	Protein conserved in bacteria
MC49_RS09585	COG2066	Belongs to the glutaminase family
MC49_RS09595	COG4607	ABC-type enterochelin transport system periplasmic component
MC49_RS09600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC49_RS09605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MC49_RS09610	COG0762	integral membrane protein
MC49_RS09615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MC49_RS09620	COG2805	Type II/IV secretion system protein
MC49_RS09625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MC49_RS09630	COG1678	Uncharacterized ACR, COG1678
MC49_RS09635	COG0189	ligase activity
MC49_RS09640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MC49_RS09660	COG0583	DNA-binding transcription factor activity
MC49_RS09665	COG0583	DNA-binding transcription factor activity
MC49_RS09675	COG1902	pentaerythritol trinitrate reductase activity
MC49_RS09685	COG1960	acyl-CoA dehydrogenase activity
MC49_RS09695	COG0121	glutamine amidotransferase
MC49_RS09700	COG3034	peptidoglycan biosynthetic process
MC49_RS09705	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC49_RS09710	COG1805	sodium ion transport
MC49_RS09715	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC49_RS09720	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC49_RS09725	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MC49_RS09730	COG2871	sodium ion transport
MC49_RS09735	COG1477	protein flavinylation
MC49_RS09740	COG2991	Protein conserved in bacteria
MC49_RS09755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC49_RS09760	COG2195	Cleaves the N-terminal amino acid of tripeptides
MC49_RS09765	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MC49_RS09770	COG1073	alpha beta
MC49_RS09780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MC49_RS09785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MC49_RS09790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MC49_RS09805	COG1546	Belongs to the CinA family
MC49_RS09810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MC49_RS09815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MC49_RS09820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MC49_RS09850	COG2918	glutathione biosynthetic process
MC49_RS09860	COG4536	flavin adenine dinucleotide binding
MC49_RS09865	COG4137	Cytochrome C assembly protein
MC49_RS09870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MC49_RS09885	COG0336	Belongs to the RNA methyltransferase TrmD family
MC49_RS09890	COG0335	large ribosomal subunit rRNA binding
MC49_RS09895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC49_RS09900	COG0287	Prephenate dehydrogenase
MC49_RS09900	COG1605	Chorismate mutase
MC49_RS09910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MC49_RS09915	COG0077	Prephenate dehydratase
MC49_RS09915	COG1605	Chorismate mutase
MC49_RS09920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MC49_RS09925	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC49_RS09940	COG0542	response to heat
MC49_RS09975	COG5544	Lipoprotein
MC49_RS09980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC49_RS09985	COG1042	CoA-binding domain protein
MC49_RS09985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC49_RS09985	COG0045	succinate-CoA ligase (ADP-forming) activity
MC49_RS09990	COG3148	PFAM DTW domain containing protein
MC49_RS09995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC49_RS10005	COG2814	Major facilitator Superfamily
MC49_RS10010	COG1566	PFAM secretion protein HlyD family protein
MC49_RS10015	COG1846	Transcriptional regulator
MC49_RS10020	COG2814	Major facilitator Superfamily
MC49_RS10025	COG2113	Glycine betaine
MC49_RS10030	COG4176	ABC-type proline glycine betaine transport system permease component
MC49_RS10035	COG4175	Glycine betaine
MC49_RS10055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MC49_RS10060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MC49_RS10065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC49_RS10070	COG1278	Cold shock
MC49_RS10075	COG0697	spore germination
MC49_RS10080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MC49_RS10090	COG2921	Belongs to the UPF0250 family
MC49_RS10095	COG1686	Belongs to the peptidase S11 family
MC49_RS10100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MC49_RS10105	COG0772	Belongs to the SEDS family
MC49_RS10110	COG0768	penicillin binding
MC49_RS10115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MC49_RS10120	COG0799	negative regulation of ribosome biogenesis
MC49_RS10130	COG1733	regulation of RNA biosynthetic process
MC49_RS10135	COG4221	oxidoreductase activity
MC49_RS10145	COG1466	dna polymerase III delta subunit
MC49_RS10150	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MC49_RS10155	COG0495	leucyl-tRNA aminoacylation
MC49_RS10160	COG1126	abc transporter atp-binding protein
MC49_RS10165	COG0765	amino acid transport
MC49_RS10170	COG0765	amino acid transport
MC49_RS10185	COG4232	protein-disulfide reductase activity
MC49_RS10195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC49_RS10200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MC49_RS10210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MC49_RS10215	COG1702	phosphate starvation-inducible protein PhoH
MC49_RS10220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC49_RS10225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC49_RS10265	COG1940	carbohydrate kinase activity
MC49_RS10265	COG1846	Transcriptional regulator
MC49_RS10270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MC49_RS10275	COG0363	glucosamine-6-phosphate deaminase activity
MC49_RS10280	COG1263	PTS System
MC49_RS10280	COG2190	(PTS) system
MC49_RS10280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS10285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC49_RS10290	COG0735	belongs to the Fur family
MC49_RS10295	COG0716	FMN binding
MC49_RS10310	COG0596	Alpha beta hydrolase
MC49_RS10315	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MC49_RS10320	COG0033	Phosphoglucomutase
MC49_RS10335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MC49_RS10340	COG2814	Major facilitator Superfamily
MC49_RS10350	COG0372	Belongs to the citrate synthase family
MC49_RS10360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MC49_RS10365	COG1053	succinate dehydrogenase
MC49_RS10380	COG0567	Dehydrogenase, E1 component
MC49_RS10385	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC49_RS10390	COG0045	succinate-CoA ligase (ADP-forming) activity
MC49_RS10395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MC49_RS10400	COG1271	oxidase subunit
MC49_RS10405	COG1294	oxidase, subunit
MC49_RS10410	COG4890	Cyd operon protein YbgT
MC49_RS10415	COG3790	cyd operon protein YbgE
MC49_RS10420	COG0583	DNA-binding transcription factor activity
MC49_RS10425	COG2814	Major facilitator Superfamily
MC49_RS10435	COG0824	Thioesterase
MC49_RS10440	COG0811	peptide transport
MC49_RS10445	COG0848	biopolymer transport protein
MC49_RS10450	COG3064	Membrane
MC49_RS10450	COG3064	Membrane
MC49_RS10455	COG0823	Involved in the tonB-independent uptake of proteins
MC49_RS10460	COG2885	chlorophyll binding
MC49_RS10465	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MC49_RS10495	COG2354	Protein conserved in bacteria
MC49_RS10500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC49_RS10505	COG0588	phosphoglycerate mutase activity
MC49_RS10515	COG1119	ATPase activity
MC49_RS10525	COG3585	molybdate ion transport
MC49_RS10525	COG2005	Transcriptional regulator
MC49_RS10540	COG0725	ABC transporter, periplasmic molybdate-binding protein
MC49_RS10545	COG4149	molybdate abc transporter
MC49_RS10550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MC49_RS10560	COG0561	phosphatase activity
MC49_RS10565	COG2706	6-phosphogluconolactonase activity
MC49_RS10575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MC49_RS10585	COG2226	methyltransferase
MC49_RS10590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MC49_RS10595	COG0556	nucleotide-excision repair
MC49_RS10610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MC49_RS10620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MC49_RS10625	COG0314	molybdopterin synthase activity
MC49_RS10630	COG0670	Belongs to the BI1 family
MC49_RS10640	COG0842	Transport permease protein
MC49_RS10645	COG0842	Transport permease protein
MC49_RS10650	COG1131	(ABC) transporter
MC49_RS10660	COG1309	transcriptional regulator
MC49_RS10665	COG0513	Belongs to the DEAD box helicase family
MC49_RS10670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC49_RS10675	COG2261	transglycosylase associated protein
MC49_RS10680	COG2897	thiosulfate sulfurtransferase activity
MC49_RS10700	COG5006	permease, DMT superfamily
MC49_RS10720	COG0531	amino acid
MC49_RS10725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MC49_RS10730	COG0402	S-adenosylhomocysteine deaminase activity
MC49_RS10735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC49_RS10740	COG0303	'Molybdopterin
MC49_RS10745	COG0477	Major facilitator Superfamily
MC49_RS10755	COG0302	gtp cyclohydrolase
MC49_RS10760	COG2311	Membrane
MC49_RS10765	COG2949	membrane
MC49_RS10770	COG0281	malic enzyme
MC49_RS10780	COG1346	cytolysis
MC49_RS10785	COG1380	Effector of murein hydrolase LrgA
MC49_RS10790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC49_RS10790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC49_RS10800	COG0489	protein tyrosine kinase activity
MC49_RS10805	COG0572	uridine kinase
MC49_RS10810	COG0717	Belongs to the dCTP deaminase family
MC49_RS10815	COG2982	Protein involved in outer membrane biogenesis
MC49_RS10820	COG3069	C4-dicarboxylate transmembrane transporter activity
MC49_RS10825	COG0307	riboflavin synthase, alpha
MC49_RS10840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MC49_RS10855	COG0025	NhaP-type Na H and K H
MC49_RS10865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC49_RS10870	COG0140	phosphoribosyl-ATP diphosphatase activity
MC49_RS10870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MC49_RS10885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MC49_RS10890	COG0131	Imidazoleglycerol-phosphate dehydratase
MC49_RS10890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MC49_RS10895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MC49_RS10895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MC49_RS10900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MC49_RS10905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MC49_RS10915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC49_RS10920	COG0625	glutathione transferase activity
MC49_RS10925	COG1686	Belongs to the peptidase S11 family
MC49_RS10935	COG1760	l-serine dehydratase
MC49_RS10940	COG0814	amino acid
MC49_RS10950	COG0814	amino acid
MC49_RS10955	COG0671	phosphoesterase, PA-phosphatase related
MC49_RS10975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC49_RS10980	COG4160	amino acid transport
MC49_RS10985	COG4215	(ABC) transporter
MC49_RS10990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC49_RS10995	COG1126	abc transporter atp-binding protein
MC49_RS11000	COG0702	epimerase
MC49_RS11005	COG2431	L-lysine efflux transmembrane transporter activity
MC49_RS11010	COG3593	DNA synthesis involved in DNA repair
MC49_RS11015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC49_RS11020	COG0577	efflux transmembrane transporter activity
MC49_RS11020	COG1136	(ABC) transporter
MC49_RS11025	COG1278	Cold shock
MC49_RS11030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MC49_RS11035	COG0542	response to heat
MC49_RS11040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MC49_RS11045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MC49_RS11050	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MC49_RS11060	COG0492	ferredoxin-NADP+ reductase activity
MC49_RS11065	COG1522	sequence-specific DNA binding
MC49_RS11070	COG3107	peptidoglycan biosynthetic process
MC49_RS11070	COG1674	ftsk spoiiie
MC49_RS11075	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MC49_RS11080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MC49_RS11085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MC49_RS11095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MC49_RS11100	COG1882	Formate acetyltransferase
MC49_RS11105	COG2116	formate transmembrane transporter activity
MC49_RS11110	COG1944	ATP diphosphatase activity
MC49_RS11115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MC49_RS11120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MC49_RS11125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MC49_RS11130	COG0539	negative regulation of cytoplasmic translation
MC49_RS11140	COG0658	competence protein
MC49_RS11140	COG2333	competence protein COMEC
MC49_RS11150	COG1663	tetraacyldisaccharide 4'-kinase activity
MC49_RS11155	COG1278	Cold shock
MC49_RS11160	COG2835	tetraacyldisaccharide 4'-kinase activity
MC49_RS11165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MC49_RS11170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MC49_RS11175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC49_RS11180	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
MC49_RS11185	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MC49_RS11190	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MC49_RS11195	COG1335	isochorismatase
MC49_RS11205	COG2989	Protein conserved in bacteria
MC49_RS11210	COG3108	Peptidase M15
MC49_RS11215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC49_RS11220	COG1448	Aminotransferase
MC49_RS11225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MC49_RS11235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MC49_RS11240	COG0308	aminopeptidase N
MC49_RS11245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MC49_RS11250	COG0167	dihydroorotate dehydrogenase activity
MC49_RS11260	COG0633	Ferredoxin
MC49_RS11260	COG3217	Mosc domain protein beta barrel domain protein
MC49_RS11265	COG0116	Belongs to the methyltransferase superfamily
MC49_RS11265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MC49_RS11270	COG0488	(ABC) transporter
MC49_RS11275	COG2995	paraquat-inducible protein a
MC49_RS11280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MC49_RS11280	COG3008	intermembrane lipid transfer
MC49_RS11290	COG3130	regulation of translation
MC49_RS11300	COG1067	ATP-dependent peptidase activity
MC49_RS11305	COG3120	sequence-specific DNA binding
MC49_RS11325	COG1289	transmembrane transporter activity
MC49_RS11330	COG0210	DNA helicase
MC49_RS11335	COG1803	Methylglyoxal synthase
MC49_RS11340	COG1832	CoA-binding protein
MC49_RS11345	COG3785	DNA binding
MC49_RS11350	COG1254	Belongs to the acylphosphatase family
MC49_RS11355	COG2920	part of a sulfur-relay system
MC49_RS11380	COG3383	formate dehydrogenase (NAD+) activity
MC49_RS11385	COG2391	methyltransferase activity
MC49_RS11390	COG0425	Belongs to the sulfur carrier protein TusA family
MC49_RS11395	COG1811	Na channel or pump
MC49_RS11405	COG2388	GCN5-related N-acetyl-transferase
MC49_RS11415	COG3615	Tellurite resistance protein tehB
MC49_RS11430	COG3539	Fimbrial protein
MC49_RS11480	COG3539	Fimbrial protein
MC49_RS11495	COG2207	Transcriptional regulator
MC49_RS11495	COG3708	Transcriptional regulator
MC49_RS11500	COG0840	transmembrane signaling receptor activity
MC49_RS11510	COG4221	oxidoreductase activity
MC49_RS11520	COG1982	Orn Lys Arg decarboxylase major
MC49_RS11530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC49_RS11535	COG0583	DNA-binding transcription factor activity
MC49_RS11540	COG0583	DNA-binding transcription factor activity
MC49_RS11545	COG0697	spore germination
MC49_RS11570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MC49_RS11585	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
MC49_RS11590	COG1924	4 iron, 4 sulfur cluster binding
MC49_RS11600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MC49_RS11600	COG1013	pyruvate-flavodoxin oxidoreductase activity
MC49_RS11600	COG0674	pyruvate-flavodoxin oxidoreductase activity
MC49_RS11600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC49_RS11615	COG1683	Conserved Protein
MC49_RS11620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MC49_RS11630	COG1953	Uracil, thiamine, allantoin
MC49_RS11650	COG1247	-acetyltransferase
MC49_RS11665	COG2914	Belongs to the UPF0125 (RnfH) family
MC49_RS11670	COG2867	negative regulation of translational initiation
MC49_RS11710	COG3157	Type VI secretion system effector, Hcp
MC49_RS11715	COG1414	Transcriptional regulator
MC49_RS11720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MC49_RS11725	COG2271	Major facilitator Superfamily
MC49_RS11730	COG2721	sulfolactate sulfo-lyase activity
MC49_RS11735	COG0477	Major facilitator Superfamily
MC49_RS11740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC49_RS11745	COG0497	DNA recombination
MC49_RS11750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MC49_RS11755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MC49_RS11760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MC49_RS11765	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
MC49_RS11775	COG0513	Belongs to the DEAD box helicase family
MC49_RS11800	COG3026	antisigma factor binding
MC49_RS11805	COG3086	response to oxidative stress
MC49_RS11830	COG0681	Belongs to the peptidase S26 family
MC49_RS11835	COG0571	ribonuclease III activity
MC49_RS11840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MC49_RS11850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MC49_RS11860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC49_RS11885	COG3157	Type VI secretion system effector, Hcp
MC49_RS11995	COG0024	Methionine aminopeptidase
MC49_RS12000	COG1309	transcriptional regulator
MC49_RS12005	COG0477	Major facilitator Superfamily
MC49_RS12020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MC49_RS12025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MC49_RS12025	COG0047	phosphoribosylformylglycinamidine synthase activity
MC49_RS12030	COG4771	TonB-dependent receptor
MC49_RS12035	COG4178	(ABC) transporter
MC49_RS12040	COG0612	Peptidase, M16
MC49_RS12050	COG2205	protein histidine kinase activity
MC49_RS12055	COG3170	Tfp pilus assembly protein FimV
MC49_RS12060	COG2204	response regulator
MC49_RS12065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MC49_RS12065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC49_RS12070	COG0347	Belongs to the P(II) protein family
MC49_RS12080	COG1017	nitric oxide dioxygenase activity
MC49_RS12080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MC49_RS12085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MC49_RS12090	COG2814	Major facilitator Superfamily
MC49_RS12100	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MC49_RS12105	COG1959	2 iron, 2 sulfur cluster binding
MC49_RS12110	COG1104	cysteine desulfurase activity
MC49_RS12115	COG0822	iron-sulfur transferase activity
MC49_RS12120	COG0316	Belongs to the HesB IscA family
MC49_RS12125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MC49_RS12130	COG0443	Heat shock 70 kDa protein
MC49_RS12135	COG0633	Ferredoxin
MC49_RS12140	COG2975	iron-sulfur cluster assembly
MC49_RS12145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MC49_RS12155	COG2373	Large extracellular alpha-helical protein
MC49_RS12160	COG4953	penicillin-binding protein 1C
MC49_RS12165	COG0105	UTP biosynthetic process
MC49_RS12170	COG0589	response to stress
MC49_RS12175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MC49_RS12190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MC49_RS12195	COG0124	histidyl-tRNA synthetase
MC49_RS12200	COG2976	Protein conserved in bacteria
MC49_RS12205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC49_RS12210	COG1160	GTP binding
MC49_RS12240	COG2837	iron assimilation
MC49_RS12245	COG4150	thiosulfate binding
MC49_RS12255	COG4208	sulfate ABC transporter
MC49_RS12260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MC49_RS12265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC49_RS12270	COG0519	Catalyzes the synthesis of GMP from XMP
MC49_RS12285	COG0727	PFAM Uncharacterised protein family (UPF0153)
MC49_RS12290	COG2207	Transcriptional regulator
MC49_RS12295	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC49_RS12310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC49_RS12310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC49_RS12315	COG2207	Transcriptional regulator
MC49_RS12325	COG2814	Major facilitator Superfamily
MC49_RS12330	COG1560	Kdo2-lipid A biosynthetic process
MC49_RS12365	COG0418	dihydroorotase activity
MC49_RS12370	COG1396	sequence-specific DNA binding
MC49_RS12440	COG0835	chemotaxis
MC49_RS12450	COG0840	transmembrane signaling receptor activity
MC49_RS12455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MC49_RS12460	COG2201	protein-glutamate methylesterase activity
MC49_RS12465	COG0745	RESPONSE REGULATOR receiver
MC49_RS12480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MC49_RS12515	COG1815	bacterial-type flagellum-dependent cell motility
MC49_RS12520	COG1558	bacterial-type flagellum-dependent cell motility
MC49_RS12525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MC49_RS12540	COG4786	Flagellar basal body rod
MC49_RS12545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MC49_RS12550	COG1706	bacterial-type flagellum-dependent cell motility
MC49_RS12560	COG1256	bacterial-type flagellum assembly
MC49_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
MC49_RS12585	COG1987	bacterial-type flagellum assembly
MC49_RS12590	COG1338	Plays a role in the flagellum-specific transport system
MC49_RS12610	COG1580	Controls the rotational direction of flagella during chemotaxis
MC49_RS12615	COG3144	bacterial-type flagellum assembly
MC49_RS12620	COG2882	bacterial-type flagellum organization
MC49_RS12625	COG1157	protein secretion by the type III secretion system
MC49_RS12630	COG1317	bacterial-type flagellum organization
MC49_RS12635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC49_RS12640	COG1766	The M ring may be actively involved in energy transduction
MC49_RS12645	COG1677	Flagellar hook-basal body complex protein FliE
MC49_RS12665	COG3042	response to heat
MC49_RS12710	COG1191	sigma factor activity
MC49_RS12720	COG0506	proline dehydrogenase activity
MC49_RS12720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MC49_RS12720	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MC49_RS12730	COG1113	amino acid transport
MC49_RS12740	COG1216	Glycosyl transferase, family 2
MC49_RS12745	COG2194	sulfuric ester hydrolase activity
MC49_RS12755	COG2252	PERMEase
MC49_RS12770	COG0765	amino acid transport
MC49_RS12785	COG4589	Belongs to the CDS family
MC49_RS12800	COG0626	cystathionine gamma-synthase activity
MC49_RS12805	COG0814	amino acid
MC49_RS12810	COG0633	Ferredoxin
MC49_RS12815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC49_RS12820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC49_RS12825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC49_RS12835	COG2205	protein histidine kinase activity
MC49_RS12835	COG0784	Response regulator, receiver
MC49_RS12840	COG2197	response regulator
MC49_RS12845	COG0642	Histidine kinase
MC49_RS12845	COG2198	Histidine kinase
MC49_RS12860	COG0582	viral genome integration into host DNA
MC49_RS12870	COG0629	single-stranded DNA binding
MC49_RS12945	COG1484	DNA-dependent DNA replication
MC49_RS12980	COG0675	Transposase, IS605 OrfB family
MC49_RS13005	COG1278	Cold shock
MC49_RS13010	COG1560	Kdo2-lipid A biosynthetic process
MC49_RS13035	COG3772	lysozyme
MC49_RS13060	COG3728	DNA packaging
MC49_RS13060	COG5484	DNA packaging
MC49_RS13175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MC49_RS13180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC49_RS13210	COG1278	Cold shock
MC49_RS13250	COG0071	Belongs to the small heat shock protein (HSP20) family
MC49_RS13275	COG3772	lysozyme
MC49_RS13445	COG3738	Protein conserved in bacteria
MC49_RS13460	COG3708	Transcriptional regulator
MC49_RS13460	COG2207	Transcriptional regulator
MC49_RS13485	COG0668	transmembrane transport
MC49_RS13490	COG3247	response to pH
MC49_RS13530	COG0321	lipoyl(octanoyl) transferase activity
MC49_RS13530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MC49_RS13540	COG1770	oligopeptidase
MC49_RS13545	COG1570	exodeoxyribonuclease VII activity
MC49_RS13550	COG0516	GMP reductase activity
MC49_RS13550	COG0517	IMP dehydrogenase activity
MC49_RS13555	COG0519	Catalyzes the synthesis of GMP from XMP
MC49_RS13555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MC49_RS13560	COG0326	Molecular chaperone. Has ATPase activity
MC49_RS13565	COG1335	isochorismatase
MC49_RS13575	COG2814	Major facilitator Superfamily
MC49_RS13590	COG0823	Involved in the tonB-independent uptake of proteins
MC49_RS13610	COG2226	methyltransferase
MC49_RS13615	COG1971	Probably functions as a manganese efflux pump
MC49_RS13620	COG4811	Protein of unknown function (DUF986)
MC49_RS13625	COG3716	PTS system mannose fructose sorbose family IID component
MC49_RS13630	COG3715	PTS system
MC49_RS13635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS13635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC49_RS13640	COG1760	l-serine dehydratase
MC49_RS13645	COG0494	nUDIX hydrolase
MC49_RS13670	COG1528	Iron-storage protein
MC49_RS13680	COG1276	copper resistance
MC49_RS13690	COG1956	GAF domain-containing protein
MC49_RS13695	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MC49_RS13705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC49_RS13710	COG3189	MarR family transcriptional regulator
MC49_RS13715	COG0113	porphobilinogen synthase activity
MC49_RS13745	COG0589	response to stress
MC49_RS13770	COG2966	Psort location CytoplasmicMembrane, score
MC49_RS13775	COG3610	response to peptide
MC49_RS13780	COG2356	endonuclease I
MC49_RS13785	COG1702	phosphate starvation-inducible protein PhoH
MC49_RS13790	COG2375	cellular response to nickel ion
MC49_RS13800	COG1294	oxidase, subunit
MC49_RS13805	COG1271	oxidase subunit
MC49_RS13810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC49_RS13825	COG1280	lysine exporter protein (LysE YggA)
MC49_RS13840	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC49_RS13845	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC49_RS13850	COG1129	ABC transporter
MC49_RS13860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC49_RS13865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC49_RS13885	COG0012	GTP binding
MC49_RS13890	COG0193	aminoacyl-tRNA hydrolase activity
MC49_RS13900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MC49_RS13905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MC49_RS13910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MC49_RS13915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MC49_RS13920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MC49_RS13935	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MC49_RS13940	COG1242	4 iron, 4 sulfur cluster binding
MC49_RS13950	COG0659	secondary active sulfate transmembrane transporter activity
MC49_RS13965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC49_RS13970	COG3381	protein complex oligomerization
MC49_RS13975	COG2851	Citrate transporter
MC49_RS13985	COG0477	Major facilitator Superfamily
MC49_RS13990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC49_RS14005	COG0018	arginyl-trna synthetase
MC49_RS14010	COG3102	Protein conserved in bacteria
MC49_RS14015	COG3142	Participates in the control of copper homeostasis
MC49_RS14025	COG0500	methyltransferase
MC49_RS14035	COG3788	relative of glutathione S-transferase, MAPEG superfamily
MC49_RS14040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MC49_RS14045	COG0494	nUDIX hydrolase
MC49_RS14050	COG0217	transcriptional regulatory protein
MC49_RS14055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MC49_RS14060	COG0632	four-way junction helicase activity
MC49_RS14065	COG2255	four-way junction helicase activity
MC49_RS14075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC49_RS14080	COG1121	(ABC) transporter
MC49_RS14085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MC49_RS14090	COG0739	heme binding
MC49_RS14095	COG1560	Kdo2-lipid A biosynthetic process
MC49_RS14100	COG0469	pyruvate kinase activity
MC49_RS14105	COG1737	Transcriptional regulator
MC49_RS14110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MC49_RS14115	COG2076	Multidrug Resistance protein
MC49_RS14120	COG2076	Multidrug Resistance protein
MC49_RS14125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS14130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC49_RS14135	COG1957	nucleoside hydrolase
MC49_RS14140	COG0745	RESPONSE REGULATOR receiver
MC49_RS14145	COG2205	protein histidine kinase activity
MC49_RS14170	COG1830	Aldolase
MC49_RS14180	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC49_RS14185	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC49_RS14195	COG2390	Transcriptional regulator
MC49_RS14200	COG1070	Carbohydrate kinase
MC49_RS14205	COG0251	oxidation-reduction process
MC49_RS14210	COG1199	ATP-dependent helicase activity
MC49_RS14220	COG3065	identical protein binding
MC49_RS14225	COG0318	PFAM AMP-dependent synthetase and ligase
MC49_RS14230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MC49_RS14235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MC49_RS14240	COG2894	cell division
MC49_RS14245	COG0850	regulation of cytokinetic process
MC49_RS14250	COG3100	YcgL domain-containing protein
MC49_RS14255	COG2951	lytic endotransglycosylase activity
MC49_RS14260	COG0179	Fumarylacetoacetate (FAA) hydrolase
MC49_RS14265	COG2983	Belongs to the UPF0260 family
MC49_RS14275	COG2226	methyltransferase
MC49_RS14285	COG1120	ATPase activity
MC49_RS14290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC49_RS14320	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC49_RS14335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC49_RS14340	COG2911	Protein conserved in bacteria
MC49_RS14350	COG3784	Protein of unknown function (DUF1318)
MC49_RS14360	COG1643	Atp-dependent helicase
MC49_RS14365	COG0531	amino acid
MC49_RS14375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MC49_RS14380	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MC49_RS14390	COG0589	response to stress
MC49_RS14400	COG0604	alcohol dehydrogenase
MC49_RS14400	COG1028	Short-chain dehydrogenase reductase Sdr
MC49_RS14400	COG3321	synthase
MC49_RS14405	COG1695	Transcriptional regulator
MC49_RS14410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MC49_RS14415	COG1263	PTS System
MC49_RS14415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS14420	COG1609	Transcriptional regulator
MC49_RS14440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MC49_RS14465	COG0697	spore germination
MC49_RS14495	COG2850	peptidyl-arginine hydroxylation
MC49_RS14500	COG4628	conserved protein (DUF2132)
MC49_RS14505	COG2897	thiosulfate sulfurtransferase activity
MC49_RS14510	COG2391	methyltransferase activity
MC49_RS14515	COG4771	TonB-dependent receptor
MC49_RS14520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC49_RS14525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC49_RS14530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MC49_RS14535	COG1902	pentaerythritol trinitrate reductase activity
MC49_RS14540	COG1309	transcriptional regulator
MC49_RS14545	COG0443	Heat shock 70 kDa protein
MC49_RS14560	COG0402	S-adenosylhomocysteine deaminase activity
MC49_RS14565	COG4807	Protein conserved in bacteria
MC49_RS14610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC49_RS14615	COG1671	Belongs to the UPF0178 family
MC49_RS14630	COG0488	(ABC) transporter
MC49_RS14640	COG2076	Multidrug Resistance protein
MC49_RS14655	COG0697	spore germination
MC49_RS14670	COG0494	nUDIX hydrolase
MC49_RS14675	COG0456	acetyltransferase
MC49_RS14675	COG1846	Transcriptional regulator
MC49_RS14680	COG0583	DNA-binding transcription factor activity
MC49_RS14685	COG0814	amino acid
MC49_RS14690	COG0626	cystathionine gamma-synthase activity
MC49_RS14725	COG0590	tRNA wobble adenosine to inosine editing
MC49_RS14730	COG0583	DNA-binding transcription factor activity
MC49_RS14745	COG0477	Major facilitator Superfamily
MC49_RS14765	COG2814	Major facilitator Superfamily
MC49_RS14775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC49_RS14840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC49_RS14850	COG0789	Transcriptional regulator
MC49_RS14855	COG2814	Major facilitator Superfamily
MC49_RS14895	COG0488	(ABC) transporter
MC49_RS14905	COG2169	Transcriptional regulator
MC49_RS14905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC49_RS14910	COG3145	DNA-N1-methyladenine dioxygenase activity
MC49_RS14930	COG2079	MmgE PrpD family protein
MC49_RS14940	COG4221	oxidoreductase activity
MC49_RS14955	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MC49_RS14960	COG1940	carbohydrate kinase activity
MC49_RS14970	COG0583	DNA-binding transcription factor activity
MC49_RS14975	COG2814	Major facilitator Superfamily
MC49_RS14985	COG0114	fumarate hydratase activity
MC49_RS14990	COG1482	cell wall glycoprotein biosynthetic process
MC49_RS14995	COG5339	Protein conserved in bacteria
MC49_RS15000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MC49_RS15005	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MC49_RS15010	COG0385	Bile acid
MC49_RS15015	COG0673	inositol 2-dehydrogenase activity
MC49_RS15020	COG4657	Part of a membrane complex involved in electron transport
MC49_RS15030	COG4656	Part of a membrane complex involved in electron transport
MC49_RS15040	COG4659	FMN binding
MC49_RS15050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MC49_RS15055	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MC49_RS15065	COG0023	Translation Initiation Factor
MC49_RS15070	COG0284	orotidine-5'-phosphate decarboxylase activity
MC49_RS15075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MC49_RS15080	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
MC49_RS15085	COG0671	phosphoesterase, PA-phosphatase related
MC49_RS15090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC49_RS15105	COG0583	DNA-binding transcription factor activity
MC49_RS15120	COG0616	signal peptide processing
MC49_RS15125	COG1028	Short-chain dehydrogenase reductase Sdr
MC49_RS15140	COG0009	L-threonylcarbamoyladenylate synthase
MC49_RS15155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC49_RS15155	COG0512	Glutamine amidotransferase of anthranilate synthase
MC49_RS15160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC49_RS15160	COG0512	Glutamine amidotransferase of anthranilate synthase
MC49_RS15165	COG0135	phosphoribosylanthranilate isomerase activity
MC49_RS15165	COG0134	indole-3-glycerol-phosphate synthase activity
MC49_RS15170	COG0133	tryptophan synthase activity
MC49_RS15175	COG0159	tryptophan synthase activity
MC49_RS15185	COG3047	cAMP biosynthetic process
MC49_RS15200	COG3111	PFAM Bacterial OB fold (BOF) protein
MC49_RS15210	COG0642	Histidine kinase
MC49_RS15220	COG2917	probably involved in intracellular septation
MC49_RS15230	COG0513	Belongs to the DEAD box helicase family
MC49_RS15250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC49_RS15255	COG3099	Belongs to the UPF0263 family
MC49_RS15280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC49_RS15285	COG0601	transmembrane transport
MC49_RS15295	COG4166	transmembrane transport
MC49_RS15305	COG0747	negative chemotaxis
MC49_RS15310	COG0601	transmembrane transport
MC49_RS15315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC49_RS15320	COG0444	Belongs to the ABC transporter superfamily
MC49_RS15325	COG4608	Belongs to the ABC transporter superfamily
MC49_RS15330	COG2095	MarC family integral membrane protein
MC49_RS15335	COG1012	belongs to the aldehyde dehydrogenase family
MC49_RS15335	COG1454	alcohol dehydrogenase
MC49_RS15340	COG1435	thymidine kinase activity
MC49_RS15360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC49_RS15365	COG0745	RESPONSE REGULATOR receiver
MC49_RS15370	COG3012	SEC-C Motif Domain Protein
MC49_RS15375	COG0788	formyltetrahydrofolate deformylase activity
MC49_RS15390	COG0708	Exodeoxyribonuclease III
MC49_RS15395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC49_RS15405	COG0778	Nitroreductase
MC49_RS15410	COG0616	signal peptide processing
MC49_RS15415	COG0252	asparaginase activity
MC49_RS15420	COG1335	isochorismatase
MC49_RS15425	COG3139	Protein of unknown function (DUF1315)
MC49_RS15430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC49_RS15435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC49_RS15445	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MC49_RS15450	COG3713	MltA-interacting MipA family protein
MC49_RS15455	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MC49_RS15460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC49_RS15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC49_RS15475	COG2186	Transcriptional regulator
MC49_RS15480	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MC49_RS15485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MC49_RS15490	COG3042	response to heat
MC49_RS15510	COG0488	(ABC) transporter
MC49_RS15540	COG1396	sequence-specific DNA binding
MC49_RS15545	COG1396	sequence-specific DNA binding
MC49_RS15555	COG0598	Magnesium transport protein CorA
MC49_RS15560	COG4166	transmembrane transport
MC49_RS15575	COG3768	UPF0283 membrane protein
MC49_RS15580	COG3106	COG3106 Predicted ATPase
MC49_RS15590	COG1983	PspC domain protein
MC49_RS15600	COG1842	Phage shock protein A
MC49_RS15605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MC49_RS15610	COG4166	transmembrane transport
MC49_RS15620	COG4171	peptide transport system, permease
MC49_RS15630	COG4172	Belongs to the ABC transporter superfamily
MC49_RS15665	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MC49_RS15670	COG3133	Outer membrane lipoprotein
MC49_RS15675	COG1846	Transcriptional regulator
MC49_RS15680	COG3313	Fe-S protein
MC49_RS15685	COG0346	lactoylglutathione lyase activity
MC49_RS15700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MC49_RS15705	COG1280	lysine exporter protein (LysE YggA)
MC49_RS15720	COG3122	Protein conserved in bacteria
MC49_RS15740	COG1609	Transcriptional regulator
MC49_RS15745	COG0583	DNA-binding transcription factor activity
MC49_RS15750	COG2814	Major facilitator Superfamily
MC49_RS15755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MC49_RS15760	COG0307	riboflavin synthase, alpha
MC49_RS15765	COG0534	Mate efflux family protein
MC49_RS15790	COG1388	LysM domain
MC49_RS15790	COG1376	ErfK ybiS ycfS ynhG family protein
MC49_RS15795	COG2166	iron-sulfur cluster assembly
MC49_RS15800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MC49_RS15805	COG0719	Fe-S assembly protein
MC49_RS15810	COG0396	ATPase activity
MC49_RS15815	COG0719	Fe-S assembly protein
MC49_RS15820	COG0316	Belongs to the HesB IscA family
MC49_RS15825	COG2050	protein possibly involved in aromatic compounds catabolism
MC49_RS15830	COG0247	lactate metabolic process
MC49_RS15830	COG0277	FAD linked oxidase domain protein
MC49_RS15835	COG0628	permease
MC49_RS15840	COG0574	Belongs to the PEP-utilizing enzyme family
MC49_RS15840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MC49_RS15845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MC49_RS15850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MC49_RS15855	COG4256	Hemin uptake protein
MC49_RS15860	COG3720	iron ion transport
MC49_RS15865	COG4558	Periplasmic binding protein
MC49_RS15870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC49_RS15875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MC49_RS15885	COG2207	Transcriptional regulator
MC49_RS15900	COG0791	NLP P60 protein
MC49_RS15905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MC49_RS15910	COG2076	Multidrug Resistance protein
MC49_RS15920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MC49_RS15925	COG0726	polysaccharide deacetylase
MC49_RS15930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC49_RS15930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC49_RS15940	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
MC49_RS15945	COG4139	cobalamin transport
MC49_RS15950	COG0776	regulation of translation
MC49_RS15955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC49_RS15955	COG0072	phenylalanine-tRNA ligase activity
MC49_RS15960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MC49_RS15975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MC49_RS15985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC49_RS15990	COG2194	sulfuric ester hydrolase activity
MC49_RS16000	COG0803	Belongs to the bacterial solute-binding protein 9 family
MC49_RS16005	COG1121	(ABC) transporter
MC49_RS16010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC49_RS16015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC49_RS16020	COG3001	Fructosamine kinase
MC49_RS16030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC49_RS16035	COG1988	membrane-bound metal-dependent
MC49_RS16040	COG1823	symporter activity
MC49_RS16045	COG0501	Belongs to the peptidase M48B family
MC49_RS16050	COG0346	lactoylglutathione lyase activity
MC49_RS16055	COG0280	phosphate acetyltransferase
MC49_RS16055	COG0281	malic enzyme
MC49_RS16060	COG2197	response regulator
MC49_RS16070	COG1393	Belongs to the ArsC family
MC49_RS16080	COG1876	peptidase activity
MC49_RS16085	COG2832	Protein of unknown function (DUF454)
MC49_RS16100	COG1444	tRNA N-acetyltransferase activity
MC49_RS16105	COG2707	UPF0756 membrane protein
MC49_RS16110	COG2321	neutral zinc metallopeptidase
MC49_RS16115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MC49_RS16120	COG1349	DNA-binding transcription factor activity
MC49_RS16125	COG0483	inositol monophosphate 1-phosphatase activity
MC49_RS16130	COG2223	nitrite transmembrane transporter activity
MC49_RS16135	COG1216	Glycosyl transferase, family 2
MC49_RS16140	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MC49_RS16150	COG2716	regulation of RNA biosynthetic process
MC49_RS16155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MC49_RS16160	COG3210	domain, Protein
MC49_RS16165	COG0628	permease
MC49_RS16170	COG4783	chaperone-mediated protein folding
MC49_RS16175	COG1393	Belongs to the ArsC family
MC49_RS16190	COG3210	domain, Protein
MC49_RS16195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MC49_RS16200	COG2267	carboxylic ester hydrolase activity
MC49_RS16205	COG2453	phosphatase
MC49_RS16205	COG0671	phosphoesterase, PA-phosphatase related
MC49_RS16215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MC49_RS16220	COG3210	domain, Protein
MC49_RS16225	COG2233	PERMEase
MC49_RS16230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MC49_RS16235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MC49_RS16240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MC49_RS16250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC49_RS16255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MC49_RS16260	COG0248	Ppx GppA phosphatase
MC49_RS16265	COG2239	Acts as a magnesium transporter
MC49_RS16295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC49_RS16300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC49_RS16305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC49_RS16310	COG2205	protein histidine kinase activity
MC49_RS16315	COG0745	RESPONSE REGULATOR receiver
MC49_RS16325	COG0826	peptidase U32
MC49_RS16335	COG1597	lipid kinase activity
MC49_RS16340	COG1830	Aldolase
MC49_RS16345	COG1187	pseudouridine synthase activity
MC49_RS16350	COG0351	phosphomethylpyrimidine kinase
MC49_RS16375	COG2207	Transcriptional regulator
MC49_RS16380	COG0561	phosphatase activity
MC49_RS16385	COG1114	Component of the transport system for branched-chain amino acids
MC49_RS16390	COG3023	N-Acetylmuramoyl-L-alanine amidase
MC49_RS16405	COG1115	amino acid carrier protein
MC49_RS16420	COG1584	GPR1 FUN34 yaaH family protein
MC49_RS16435	COG0318	PFAM AMP-dependent synthetase and ligase
MC49_RS16440	COG1441	menaquinone biosynthetic process
MC49_RS16450	COG0596	Alpha beta hydrolase
MC49_RS16455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MC49_RS16460	COG1169	isochorismate synthase
MC49_RS16475	COG1007	ATP synthesis coupled electron transport
MC49_RS16480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC49_RS16485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MC49_RS16490	COG0713	ATP synthesis coupled electron transport
MC49_RS16495	COG0839	Belongs to the complex I subunit 6 family
MC49_RS16500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC49_RS16505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MC49_RS16525	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC49_RS16525	COG0649	NAD binding
MC49_RS16535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC49_RS16540	COG0583	DNA-binding transcription factor activity
MC49_RS16545	COG0436	Aminotransferase
MC49_RS16550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MC49_RS16555	COG0490	domain, Protein
MC49_RS16555	COG0471	metal ion transport
MC49_RS16560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC49_RS16565	COG3013	Belongs to the UPF0304 family
MC49_RS16570	COG3092	negative regulation of chromosome organization
MC49_RS16575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MC49_RS16580	COG0280	phosphate acetyltransferase
MC49_RS16580	COG0857	belongs to the CobB CobQ family
MC49_RS16595	COG1090	epimerase
MC49_RS16600	COG0163	prenyltransferase activity
MC49_RS16605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MC49_RS16610	COG1286	toxin biosynthetic process
MC49_RS16615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MC49_RS16620	COG0285	dihydrofolate synthase activity
MC49_RS16625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MC49_RS16630	COG0586	Pfam SNARE associated Golgi protein
MC49_RS16635	COG0101	tRNA pseudouridine synthase activity
MC49_RS16640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC49_RS16645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC49_RS16655	COG0697	spore germination
MC49_RS16670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC49_RS16675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC49_RS16675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MC49_RS16700	COG3101	peptidyl-lysine hydroxylation
MC49_RS16705	COG0730	response to heat
MC49_RS16710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MC49_RS16720	COG2840	Smr protein MutS2
MC49_RS16725	COG2062	phosphohistidine phosphatase, SixA
MC49_RS16730	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC49_RS16730	COG1024	Enoyl-CoA hydratase
MC49_RS16735	COG0183	Belongs to the thiolase family
MC49_RS16740	COG3691	Protein conserved in bacteria
MC49_RS16755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC49_RS16760	COG3048	D-serine ammonia-lyase activity
MC49_RS16765	COG2610	gluconate transmembrane transporter activity
MC49_RS16770	COG0583	DNA-binding transcription factor activity
MC49_RS16795	COG3772	lysozyme
MC49_RS16825	COG1464	Belongs to the NlpA lipoprotein family
MC49_RS16850	COG3422	double-strand break repair
MC49_RS16860	COG2841	Protein conserved in bacteria
MC49_RS16890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC49_RS16895	COG2315	Protein conserved in bacteria
MC49_RS16900	COG1396	sequence-specific DNA binding
MC49_RS16905	COG0702	epimerase
MC49_RS16910	COG1733	regulation of RNA biosynthetic process
MC49_RS16915	COG0582	viral genome integration into host DNA
MC49_RS16925	COG0538	isocitrate dehydrogenase activity
MC49_RS16930	COG1187	pseudouridine synthase activity
MC49_RS16940	COG0482	sulfurtransferase activity
MC49_RS16945	COG2915	High frequency lysogenization protein hflD homolog
MC49_RS16950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MC49_RS16955	COG0745	RESPONSE REGULATOR receiver
MC49_RS16965	COG2850	peptidyl-arginine hydroxylation
MC49_RS16975	COG3188	usher protein
MC49_RS16980	COG3121	Chaperone
MC49_RS17000	COG4591	ABC-type transport system involved in lipoprotein release permease component
MC49_RS17005	COG1136	(ABC) transporter
MC49_RS17010	COG4591	ABC-type transport system involved in lipoprotein release permease component
MC49_RS17015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MC49_RS17020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MC49_RS17030	COG1252	NADH dehydrogenase
MC49_RS17035	COG3150	esterase
MC49_RS17040	COG1472	Belongs to the glycosyl hydrolase 3 family
MC49_RS17050	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
MC49_RS17055	COG0537	adenosine 5'-monophosphoramidase activity
MC49_RS17060	COG0084	hydrolase, TatD family'
MC49_RS17065	COG0470	DNA polymerase III
MC49_RS17075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MC49_RS17080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC49_RS17085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC49_RS17090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MC49_RS17100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MC49_RS17105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC49_RS17110	COG0416	fatty acid biosynthetic process
MC49_RS17115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MC49_RS17120	COG1399	metal-binding, possibly nucleic acid-binding protein
MC49_RS17125	COG0424	maF-like protein
MC49_RS17135	COG0564	pseudouridine synthase activity
MC49_RS17140	COG1530	ribonuclease E activity
MC49_RS17145	COG2926	Belongs to the UPF0265 family
MC49_RS17150	COG2925	Exonuclease
MC49_RS17160	COG0277	FAD linked oxidase domain protein
MC49_RS17165	COG0730	response to heat
MC49_RS17170	COG0531	amino acid
MC49_RS17180	COG4771	TonB-dependent receptor
MC49_RS17185	COG1120	ATPase activity
MC49_RS17190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC49_RS17200	COG0833	amino acid
MC49_RS17210	COG0583	DNA-binding transcription factor activity
MC49_RS17215	COG2855	membrane
MC49_RS17220	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MC49_RS17225	COG1105	Belongs to the carbohydrate kinase PfkB family
MC49_RS17230	COG0494	nUDIX hydrolase
MC49_RS17240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MC49_RS17255	COG0671	phosphoesterase, PA-phosphatase related
MC49_RS17260	COG0791	NLP P60 protein
MC49_RS17270	COG2814	Major facilitator Superfamily
MC49_RS17275	COG1187	pseudouridine synthase activity
MC49_RS17280	COG1061	Type III restriction enzyme res subunit
MC49_RS17285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MC49_RS17290	COG3081	Nucleoid-associated protein
MC49_RS17295	COG3082	Protein of unknown function (DUF1414)
MC49_RS17300	COG3083	sulfuric ester hydrolase activity
MC49_RS17310	COG1278	Cold shock
MC49_RS17315	COG3969	phosphoadenosine phosphosulfate
MC49_RS17320	COG1475	DNA binding
MC49_RS17335	COG0730	response to heat
MC49_RS17345	COG0586	Pfam SNARE associated Golgi protein
MC49_RS17355	COG1278	Cold shock
MC49_RS17375	COG2814	Major facilitator Superfamily
MC49_RS17385	COG1032	radical SAM domain protein
MC49_RS17405	COG1032	radical SAM domain protein
MC49_RS17410	COG1032	radical SAM domain protein
MC49_RS17420	COG1032	radical SAM domain protein
MC49_RS17655	COG2369	cell adhesion
MC49_RS17695	COG3772	lysozyme
MC49_RS17750	COG4725	Belongs to the MT-A70-like family
MC49_RS17765	COG0305	Participates in initiation and elongation during chromosome replication
MC49_RS17775	COG1802	Transcriptional regulator
MC49_RS17775	COG4626	Terminase
MC49_RS17855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MC49_RS17860	COG0322	excinuclease ABC activity
MC49_RS17865	COG2197	response regulator
MC49_RS17870	COG0778	Nitroreductase
MC49_RS17880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC49_RS17885	COG1028	Short-chain dehydrogenase reductase Sdr
MC49_RS17890	COG2837	iron assimilation
MC49_RS17895	COG2822	iron ion transport
MC49_RS17905	COG4633	Protein conserved in bacteria
MC49_RS17995	COG3530	Putative quorum-sensing-regulated virulence factor
MC49_RS18000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MC49_RS18005	COG3115	cell septum assembly
MC49_RS18020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC49_RS18025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MC49_RS18055	COG3135	benzoate transporter
MC49_RS18060	COG1396	sequence-specific DNA binding
MC49_RS18080	COG1309	transcriptional regulator
MC49_RS18115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC49_RS18120	COG0813	purine-nucleoside phosphorylase activity
MC49_RS18135	COG0477	Major facilitator Superfamily
MC49_RS18145	COG4771	TonB-dependent receptor
MC49_RS18150	COG1609	Transcriptional regulator
MC49_RS18155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC49_RS18160	COG2017	converts alpha-aldose to the beta-anomer
MC49_RS18165	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MC49_RS18170	COG1085	galactose-1-phosphate uridylyltransferase
MC49_RS18175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC49_RS18180	COG1609	Transcriptional regulator
MC49_RS18185	COG3250	beta-galactosidase activity
MC49_RS18190	COG2731	YhcH YjgK YiaL family protein
MC49_RS18195	COG0531	amino acid
MC49_RS18205	COG2233	PERMEase
MC49_RS18225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MC49_RS18245	COG2841	Protein conserved in bacteria
MC49_RS18265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC49_RS18275	COG3842	ATPase activity
MC49_RS18280	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MC49_RS18285	COG0725	ABC transporter, periplasmic molybdate-binding protein
MC49_RS18305	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MC49_RS18315	COG0583	DNA-binding transcription factor activity
MC49_RS18350	COG1309	transcriptional regulator
MC49_RS18355	COG0531	amino acid
MC49_RS18360	COG1982	Orn Lys Arg decarboxylase major
MC49_RS18385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MC49_RS18395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MC49_RS18400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MC49_RS18410	COG0716	FMN binding
MC49_RS18425	COG0354	folic acid binding
MC49_RS18435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MC49_RS18435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MC49_RS18440	COG0509	glycine decarboxylation via glycine cleavage system
MC49_RS18445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MC49_RS18450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC49_RS18455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC49_RS18460	COG0006	proline dipeptidase activity
MC49_RS18465	COG3079	Belongs to the UPF0149 family
MC49_RS18480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MC49_RS18485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC49_RS18490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MC49_RS18495	COG0583	DNA-binding transcription factor activity
MC49_RS18505	COG1279	arginine transmembrane transporter activity
MC49_RS18515	COG0668	transmembrane transport
MC49_RS18520	COG3112	Uncharacterised protein family (UPF0231)
MC49_RS18525	COG1049	propionate catabolic process, 2-methylcitrate cycle
MC49_RS18530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC49_RS18535	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC49_RS18540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MC49_RS18550	COG3023	N-Acetylmuramoyl-L-alanine amidase
MC49_RS18570	COG4969	Belongs to the N-Me-Phe pilin family
MC49_RS18575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MC49_RS18585	COG0237	dephospho-CoA kinase activity
MC49_RS18590	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MC49_RS18600	COG0494	nUDIX hydrolase
MC49_RS18605	COG0653	protein targeting
MC49_RS18620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MC49_RS18625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MC49_RS18630	COG0849	cell division
MC49_RS18635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MC49_RS18645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MC49_RS18650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MC49_RS18655	COG0772	Belongs to the SEDS family
MC49_RS18665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MC49_RS18670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MC49_RS18675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MC49_RS18680	COG0768	penicillin binding
MC49_RS18685	COG3116	cell division
MC49_RS18690	COG0275	rRNA processing
MC49_RS18695	COG2001	Belongs to the MraZ family
MC49_RS18710	COG0028	Belongs to the TPP enzyme family
MC49_RS18720	COG1022	Amp-dependent synthetase and ligase
MC49_RS18730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MC49_RS18735	COG0473	3-isopropylmalate dehydrogenase activity
MC49_RS18740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MC49_RS18750	COG4533	DNA binding
MC49_RS18755	COG3066	DNA modification
MC49_RS18780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MC49_RS18795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC49_RS18810	COG0583	DNA-binding transcription factor activity
MC49_RS18820	COG1609	Transcriptional regulator
MC49_RS18830	COG1129	ABC transporter
MC49_RS18840	COG0010	Belongs to the arginase family
MC49_RS18845	COG1166	arginine decarboxylase activity
MC49_RS18855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MC49_RS18870	COG0640	Transcriptional regulator
MC49_RS18880	COG2239	Acts as a magnesium transporter
MC49_RS18890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MC49_RS18895	COG1151	hydroxylamine reductase activity
MC49_RS18900	COG4772	TonB-dependent receptor
MC49_RS18910	COG1115	amino acid carrier protein
MC49_RS18930	COG2814	Major facilitator Superfamily
MC49_RS18935	COG1566	PFAM secretion protein HlyD family protein
MC49_RS18945	COG2353	YceI-like domain
MC49_RS18950	COG3038	cytochrome b561
MC49_RS18985	COG2390	Transcriptional regulator
MC49_RS18990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC49_RS18995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MC49_RS19000	COG1129	ABC transporter
MC49_RS19000	COG0842	Transport permease protein
MC49_RS19005	COG0842	Transport permease protein
MC49_RS19010	COG1609	Transcriptional regulator
MC49_RS19025	COG1070	Carbohydrate kinase
MC49_RS19030	COG1129	ABC transporter
MC49_RS19035	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC49_RS19040	COG1879	ABC-type sugar transport system periplasmic component
MC49_RS19065	COG3961	Belongs to the TPP enzyme family
MC49_RS19080	COG1349	DNA-binding transcription factor activity
MC49_RS19090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS19100	COG3716	PTS system mannose fructose sorbose family IID component
MC49_RS19105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC49_RS19110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MC49_RS19115	COG2222	sugar isomerase
MC49_RS19125	COG1263	PTS System
MC49_RS19125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC49_RS19135	COG2233	PERMEase
MC49_RS19140	COG0493	'glutamate synthase
MC49_RS19140	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MC49_RS19145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC49_RS19150	COG2313	pseudouridylate synthase activity
MC49_RS19155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC49_RS19155	COG1522	sequence-specific DNA binding
MC49_RS19160	COG3443	Belongs to the bacterial solute-binding protein 9 family
MC49_RS19165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MC49_RS19170	COG0254	rRNA binding