locus-tag	class	description
JW297_RS00070	COG1695	Transcriptional regulator
JW297_RS00095	COG3173	Aminoglycoside phosphotransferase
JW297_RS00105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JW297_RS00390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JW297_RS00410	COG3299	homolog of phage Mu protein gp47
JW297_RS00455	COG4386	tail sheath protein
JW297_RS00540	COG3772	lysozyme
JW297_RS00565	COG1403	HNH endonuclease
JW297_RS00650	COG5532	Uncharacterized conserved protein (DUF2303)
JW297_RS00655	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JW297_RS00690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JW297_RS00695	COG2501	S4 domain
JW297_RS00700	COG3038	cytochrome b561
JW297_RS00705	COG3783	Cytochrome b(562)
JW297_RS00715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JW297_RS00720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW297_RS00725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JW297_RS00730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JW297_RS00740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JW297_RS00745	COG4181	ATPase activity
JW297_RS00750	COG2755	lipolytic protein G-D-S-L family
JW297_RS00755	COG0300	oxidoreductase activity
JW297_RS00760	COG3118	belongs to the thioredoxin family
JW297_RS00765	COG0330	HflC and HflK could
JW297_RS00770	COG1585	Membrane protein implicated in regulation of membrane protease activity
JW297_RS00800	COG2217	Heavy metal translocating P-type atpase
JW297_RS00805	COG3735	TraB family
JW297_RS00810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW297_RS00835	COG0737	Belongs to the 5'-nucleotidase family
JW297_RS00840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JW297_RS00840	COG4651	solute:proton antiporter activity
JW297_RS00845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS00850	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
JW297_RS00870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JW297_RS00875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JW297_RS00885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JW297_RS00900	COG1196	nuclear chromosome segregation
JW297_RS00900	COG3264	Mechanosensitive ion channel
JW297_RS00905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JW297_RS00910	COG1309	transcriptional regulator
JW297_RS00915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW297_RS00920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JW297_RS00940	COG1946	Acyl-CoA thioesterase
JW297_RS00945	COG0004	ammonium transporteR
JW297_RS00950	COG0347	Belongs to the P(II) protein family
JW297_RS00955	COG1132	(ABC) transporter
JW297_RS00960	COG1132	(ABC) transporter
JW297_RS00965	COG1522	sequence-specific DNA binding
JW297_RS00980	COG0824	Thioesterase
JW297_RS00985	COG1555	photosystem II stabilization
JW297_RS00990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW297_RS01000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JW297_RS01005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JW297_RS01010	COG0740	serine-type endopeptidase activity
JW297_RS01015	COG0544	peptidyl-prolyl cis-trans isomerase activity
JW297_RS01020	COG0271	Belongs to the BolA IbaG family
JW297_RS01025	COG3056	Lipoprotein
JW297_RS01030	COG2223	nitrite transmembrane transporter activity
JW297_RS01040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JW297_RS01045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JW297_RS01050	COG1845	cytochrome c oxidase, subunit III
JW297_RS01055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JW297_RS01060	COG0109	protoheme IX farnesyltransferase activity
JW297_RS01065	COG2814	Major facilitator Superfamily
JW297_RS01070	COG1666	GTP binding
JW297_RS01075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JW297_RS01080	COG0693	protein deglycase activity
JW297_RS01090	COG0301	tRNA thio-modification
JW297_RS01090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JW297_RS01100	COG0142	geranyltranstransferase activity
JW297_RS01105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JW297_RS01110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JW297_RS01115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JW297_RS01120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JW297_RS01125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JW297_RS01125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JW297_RS01130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JW297_RS01135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JW297_RS01140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JW297_RS01145	COG1862	Preprotein translocase
JW297_RS01150	COG0343	queuine tRNA-ribosyltransferase activity
JW297_RS01155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JW297_RS01160	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JW297_RS01165	COG0450	alkyl hydroperoxide reductase
JW297_RS01175	COG5002	protein histidine kinase activity
JW297_RS01180	COG0745	RESPONSE REGULATOR receiver
JW297_RS01185	COG0420	3'-5' exonuclease activity
JW297_RS01190	COG0419	ATPase involved in DNA repair
JW297_RS01200	COG1940	carbohydrate kinase activity
JW297_RS01205	COG2974	May be involved in recombination
JW297_RS01220	COG0425	Belongs to the sulfur carrier protein TusA family
JW297_RS01225	COG2391	methyltransferase activity
JW297_RS01230	COG0309	Hydrogenase expression formation protein (HypE)
JW297_RS01235	COG0409	Hydrogenase expression formation protein
JW297_RS01240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JW297_RS01245	COG1968	undecaprenyl-diphosphatase activity
JW297_RS01250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JW297_RS01255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JW297_RS01260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JW297_RS01265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JW297_RS01270	COG0358	DNA primase activity
JW297_RS01290	COG4953	penicillin-binding protein 1C
JW297_RS01295	COG2373	Large extracellular alpha-helical protein
JW297_RS01315	COG1773	rubredoxin
JW297_RS01320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JW297_RS01325	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
JW297_RS01330	COG5557	Pfam Polysulphide reductase, NrfD
JW297_RS01335	COG0437	4 iron, 4 sulfur cluster binding
JW297_RS01340	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
JW297_RS01345	COG0733	neurotransmitter:sodium symporter activity
JW297_RS01355	COG2990	Protein conserved in bacteria
JW297_RS01360	COG0586	Pfam SNARE associated Golgi protein
JW297_RS01365	COG4575	ribosome binding
JW297_RS01370	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
JW297_RS01380	COG2259	Doxx family
JW297_RS01390	COG0583	DNA-binding transcription factor activity
JW297_RS01395	COG1741	Belongs to the pirin family
JW297_RS01405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JW297_RS01415	COG0792	nuclease activity
JW297_RS01420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JW297_RS01425	COG2823	Periplasmic or secreted lipoprotein
JW297_RS01430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JW297_RS01435	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JW297_RS01440	COG5002	protein histidine kinase activity
JW297_RS01440	COG0784	Response regulator, receiver
JW297_RS01440	COG2198	Histidine kinase
JW297_RS01445	COG0067	glutamate synthase
JW297_RS01445	COG0069	glutamate synthase activity
JW297_RS01445	COG0070	glutamate synthase
JW297_RS01450	COG0493	'glutamate synthase
JW297_RS01455	COG2969	positive regulation of protein catabolic process
JW297_RS01460	COG0625	glutathione transferase activity
JW297_RS01465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JW297_RS01470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JW297_RS01475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JW297_RS01480	COG3105	Protein conserved in bacteria
JW297_RS01485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JW297_RS01490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW297_RS01495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JW297_RS01500	COG4521	taurine ABC transporter
JW297_RS01505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JW297_RS01510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JW297_RS01515	COG2175	clavaminate synthase activity
JW297_RS01520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JW297_RS01525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JW297_RS01530	COG5007	Belongs to the BolA IbaG family
JW297_RS01540	COG2854	intermembrane phospholipid transfer
JW297_RS01545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JW297_RS01550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JW297_RS01555	COG1127	ABC transporter
JW297_RS01560	COG0530	calcium, potassium:sodium antiporter activity
JW297_RS01565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JW297_RS01565	COG0517	IMP dehydrogenase activity
JW297_RS01570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JW297_RS01575	COG3117	lipopolysaccharide transmembrane transporter activity
JW297_RS01580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JW297_RS01585	COG1137	ATPase activity
JW297_RS01590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JW297_RS01595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JW297_RS01605	COG1660	Displays ATPase and GTPase activities
JW297_RS01610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW297_RS01615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JW297_RS01630	COG0312	modulator of DNA gyrase
JW297_RS01635	COG3028	Belongs to the UPF0307 family
JW297_RS01640	COG2732	(Barnase) inhibitor
JW297_RS01645	COG4290	ribonuclease
JW297_RS01650	COG0312	modulator of DNA gyrase
JW297_RS01655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JW297_RS01660	COG3164	Protein of unknown function
JW297_RS01675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JW297_RS01680	COG1792	Involved in formation and maintenance of cell shape
JW297_RS01685	COG1077	Cell shape determining protein MreB Mrl
JW297_RS01690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JW297_RS01695	COG0511	ligase activity, forming carbon-carbon bonds
JW297_RS01700	COG0439	Biotin carboxylase
JW297_RS01705	COG2264	protein methyltransferase activity
JW297_RS01710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JW297_RS01715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JW297_RS01725	COG4626	Terminase
JW297_RS01725	COG1802	Transcriptional regulator
JW297_RS01800	COG3561	AntA/AntB antirepressor
JW297_RS01815	COG0582	viral genome integration into host DNA
JW297_RS01830	COG0477	Major facilitator Superfamily
JW297_RS01840	COG0402	S-adenosylhomocysteine deaminase activity
JW297_RS01845	COG0840	transmembrane signaling receptor activity
JW297_RS01850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JW297_RS01855	COG0745	RESPONSE REGULATOR receiver
JW297_RS01860	COG2205	protein histidine kinase activity
JW297_RS01865	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JW297_RS01885	COG0454	-acetyltransferase
JW297_RS01895	COG0410	ABC transporter
JW297_RS01900	COG0411	ABC transporter
JW297_RS01905	COG4177	L-phenylalanine transmembrane transporter activity
JW297_RS01910	COG0559	Belongs to the binding-protein-dependent transport system permease family
JW297_RS01925	COG1929	Belongs to the glycerate kinase type-1 family
JW297_RS01930	COG2610	gluconate transmembrane transporter activity
JW297_RS01935	COG3835	regulator
JW297_RS01950	COG2177	Part of the ABC transporter FtsEX involved in
JW297_RS01955	COG2884	Cell division ATP-binding protein ftsE
JW297_RS01960	COG0552	protein localization to endoplasmic reticulum
JW297_RS01960	COG0552	protein localization to endoplasmic reticulum
JW297_RS01965	COG0742	ribosomal rna small subunit methyltransferase
JW297_RS01970	COG3776	membrane
JW297_RS01980	COG3714	YhhN family
JW297_RS01990	COG3739	integral membrane protein
JW297_RS01995	COG0425	Belongs to the sulfur carrier protein TusA family
JW297_RS02000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JW297_RS02015	COG0247	lactate metabolic process
JW297_RS02025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JW297_RS02030	COG1053	succinate dehydrogenase
JW297_RS02035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JW297_RS02040	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JW297_RS02055	COG0298	carbon dioxide binding
JW297_RS02060	COG0375	protein maturation
JW297_RS02065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW297_RS02070	COG3604	Transcriptional regulator
JW297_RS02100	COG1966	Carbon starvation protein
JW297_RS02105	COG2879	small protein
JW297_RS02115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JW297_RS02125	COG3260	NADH ubiquinone oxidoreductase 20
JW297_RS02130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW297_RS02135	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
JW297_RS02135	COG3261	NADH dehydrogenase
JW297_RS02140	COG0651	ATP synthesis coupled electron transport
JW297_RS02145	COG4237	Hydrogenase 4 membrane
JW297_RS02150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JW297_RS02155	COG0650	Formate hydrogenlyase subunit 4
JW297_RS02160	COG0651	ATP synthesis coupled electron transport
JW297_RS02165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW297_RS02170	COG2194	sulfuric ester hydrolase activity
JW297_RS02180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JW297_RS02190	COG2226	methyltransferase
JW297_RS02205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JW297_RS02210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS02210	COG1263	PTS System
JW297_RS02215	COG1737	Transcriptional regulator
JW297_RS02220	COG0459	protein refolding
JW297_RS02240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JW297_RS02245	COG1309	transcriptional regulator
JW297_RS02255	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JW297_RS02300	COG3501	Rhs element vgr protein
JW297_RS02410	COG1396	sequence-specific DNA binding
JW297_RS02430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW297_RS02435	COG0601	transmembrane transport
JW297_RS02440	COG0747	negative chemotaxis
JW297_RS02445	COG2824	Alkylphosphonate utilization operon protein PhnA
JW297_RS02450	COG1396	sequence-specific DNA binding
JW297_RS02455	COG0582	viral genome integration into host DNA
JW297_RS02480	COG3121	Chaperone
JW297_RS02485	COG3188	usher protein
JW297_RS02500	COG0582	viral genome integration into host DNA
JW297_RS02525	COG3539	Fimbrial protein
JW297_RS02535	COG3188	usher protein
JW297_RS02545	COG3539	Fimbrial protein
JW297_RS02550	COG0582	viral genome integration into host DNA
JW297_RS02555	COG1957	nucleoside hydrolase
JW297_RS02560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JW297_RS02595	COG2137	regulation of response to DNA damage stimulus
JW297_RS02625	COG2992	FlgJ-related protein
JW297_RS02630	COG1696	Membrane protein involved in D-alanine export
JW297_RS02650	COG0531	amino acid
JW297_RS02660	COG0531	amino acid
JW297_RS02665	COG0124	histidyl-tRNA synthetase
JW297_RS02670	COG2188	Transcriptional regulator
JW297_RS02675	COG1397	ADP-ribosylglycohydrolase
JW297_RS02685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS02695	COG2610	gluconate transmembrane transporter activity
JW297_RS02700	COG3265	gluconokinase activity
JW297_RS02705	COG1609	Transcriptional regulator
JW297_RS02715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW297_RS02720	COG1120	ATPase activity
JW297_RS02725	COG0500	methyltransferase
JW297_RS02730	COG0157	Belongs to the NadC ModD family
JW297_RS02750	COG4978	Transcriptional regulator
JW297_RS02750	COG0789	Transcriptional regulator
JW297_RS02755	COG0668	transmembrane transport
JW297_RS02770	COG2873	o-acetylhomoserine
JW297_RS02810	COG4790	Type iii secretion
JW297_RS02855	COG2207	Transcriptional regulator
JW297_RS02895	COG1396	sequence-specific DNA binding
JW297_RS02900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JW297_RS02905	COG1177	transmembrane transport
JW297_RS02935	COG2814	Major facilitator Superfamily
JW297_RS02970	COG4932	domain protein
JW297_RS02970	COG2373	Large extracellular alpha-helical protein
JW297_RS02970	COG1388	LysM domain
JW297_RS02980	COG1388	LysM domain
JW297_RS02980	COG2373	Large extracellular alpha-helical protein
JW297_RS02980	COG4932	domain protein
JW297_RS02995	COG0584	glycerophosphoryl diester phosphodiesterase
JW297_RS03000	COG2197	response regulator
JW297_RS03005	COG3850	Histidine kinase
JW297_RS03010	COG2223	nitrite transmembrane transporter activity
JW297_RS03020	COG1140	nitrate reductase beta subunit
JW297_RS03025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
JW297_RS03030	COG2181	nitrate reductase activity
JW297_RS03045	COG1280	lysine exporter protein (LysE YggA)
JW297_RS03085	COG1473	amidohydrolase
JW297_RS03105	COG3188	usher protein
JW297_RS03140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS03155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW297_RS03190	COG3727	T/G mismatch-specific endonuclease activity
JW297_RS03195	COG2378	regulation of single-species biofilm formation
JW297_RS03200	COG0625	glutathione transferase activity
JW297_RS03210	COG1396	sequence-specific DNA binding
JW297_RS03215	COG3468	outer membrane autotransporter barrel domain protein
JW297_RS03265	COG2378	regulation of single-species biofilm formation
JW297_RS03270	COG4735	regulation of single-species biofilm formation
JW297_RS03315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JW297_RS03335	COG0582	viral genome integration into host DNA
JW297_RS03345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JW297_RS03350	COG1690	Belongs to the RtcB family
JW297_RS03355	COG4650	regulator
JW297_RS03360	COG0795	lipopolysaccharide-transporting ATPase activity
JW297_RS03365	COG0795	lipopolysaccharide-transporting ATPase activity
JW297_RS03370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JW297_RS03375	COG2927	DNA polymerase III (CHI subunit)
JW297_RS03380	COG0525	valine-tRNA ligase activity
JW297_RS03385	COG0456	acetyltransferase
JW297_RS03390	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
JW297_RS03395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JW297_RS03400	COG0540	Belongs to the ATCase OTCase family
JW297_RS03405	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JW297_RS03415	COG1309	transcriptional regulator
JW297_RS03425	COG1328	CTP reductase activity
JW297_RS03430	COG0602	queuosine metabolic process
JW297_RS03435	COG3787	Belongs to the UPF0306 family
JW297_RS03450	COG3153	acetyltransferase
JW297_RS03455	COG3154	lipid carrier protein
JW297_RS03460	COG0826	peptidase U32
JW297_RS03465	COG0826	peptidase U32
JW297_RS03490	COG3275	phosphorelay sensor kinase activity
JW297_RS03500	COG0513	Belongs to the DEAD box helicase family
JW297_RS03520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JW297_RS03525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JW297_RS03530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JW297_RS03535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JW297_RS03540	COG0195	Participates in both transcription termination and antitermination
JW297_RS03560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JW297_RS03565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JW297_RS03570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JW297_RS03575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JW297_RS03580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JW297_RS03585	COG1534	Rna-binding protein
JW297_RS03595	COG2027	D-alanyl-D-alanine carboxypeptidase
JW297_RS03600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JW297_RS03605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JW297_RS03610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JW297_RS03615	COG0142	geranyltranstransferase activity
JW297_RS03625	COG3423	Transcriptional regulator
JW297_RS03630	COG0039	L-malate dehydrogenase activity
JW297_RS03635	COG1438	arginine binding
JW297_RS03640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JW297_RS03645	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JW297_RS03655	COG2105	PFAM AIG2 family protein
JW297_RS03665	COG0729	surface antigen
JW297_RS03670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW297_RS03675	COG1253	flavin adenine dinucleotide binding
JW297_RS03685	COG1218	3'(2'),5'-bisphosphate nucleotidase
JW297_RS03690	COG0545	Peptidyl-prolyl cis-trans isomerase
JW297_RS03700	COG0359	binds to the 23S rRNA
JW297_RS03705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JW297_RS03710	COG2965	DNA replication, synthesis of RNA primer
JW297_RS03715	COG0360	Binds together with S18 to 16S ribosomal RNA
JW297_RS03720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW297_RS03725	COG0557	exoribonuclease II activity
JW297_RS03730	COG1959	2 iron, 2 sulfur cluster binding
JW297_RS03735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JW297_RS03740	COG0330	HflC and HflK could
JW297_RS03745	COG0330	HflC and HflK could
JW297_RS03750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JW297_RS03755	COG1923	regulation of RNA biosynthetic process
JW297_RS03765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JW297_RS03770	COG0860	N-Acetylmuramoyl-L-alanine amidase
JW297_RS03775	COG0802	atpase or kinase
JW297_RS03780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JW297_RS03805	COG1162	GTPase activity
JW297_RS03810	COG0688	phosphatidylethanolamine metabolic process
JW297_RS03815	COG1511	domain protein
JW297_RS03815	COG3264	Mechanosensitive ion channel
JW297_RS03825	COG0814	amino acid
JW297_RS03830	COG0561	phosphatase activity
JW297_RS03835	COG2267	carboxylic ester hydrolase activity
JW297_RS03845	COG2962	Rard protein
JW297_RS03860	COG0210	DNA helicase
JW297_RS03865	COG1011	Hydrolase
JW297_RS03880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JW297_RS03890	COG1965	Belongs to the frataxin family
JW297_RS03905	COG1587	Uroporphyrinogen-III synthase
JW297_RS03910	COG2959	enzyme of heme biosynthesis
JW297_RS03915	COG3071	HemY protein
JW297_RS03940	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JW297_RS03950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JW297_RS03955	COG2244	polysaccharide biosynthetic process
JW297_RS03960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JW297_RS03965	COG0456	acetyltransferase
JW297_RS03970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JW297_RS03975	COG1088	dTDP-glucose 4,6-dehydratase activity
JW297_RS03980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JW297_RS03985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JW297_RS03990	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
JW297_RS03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JW297_RS04000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JW297_RS04005	COG3118	belongs to the thioredoxin family
JW297_RS04010	COG0513	Belongs to the DEAD box helicase family
JW297_RS04015	COG0248	Ppx GppA phosphatase
JW297_RS04020	COG0210	DNA helicase
JW297_RS04035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JW297_RS04045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JW297_RS04050	COG0129	dihydroxy-acid dehydratase activity
JW297_RS04060	COG3978	acetolactate synthase activity
JW297_RS04080	COG3085	chromosome segregation
JW297_RS04085	COG0583	DNA-binding transcription factor activity
JW297_RS04120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JW297_RS04135	COG0009	L-threonylcarbamoyladenylate synthase
JW297_RS04140	COG0551	DNA topoisomerase type I activity
JW297_RS04145	COG0758	DNA mediated transformation
JW297_RS04150	COG0242	peptide deformylase activity
JW297_RS04155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JW297_RS04160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JW297_RS04160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JW297_RS04165	COG0569	domain protein
JW297_RS04175	COG3036	rescue of stalled ribosome
JW297_RS04180	COG0789	Transcriptional regulator
JW297_RS04195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JW297_RS04200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JW297_RS04205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JW297_RS04210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JW297_RS04215	COG0201	protein transport
JW297_RS04220	COG0200	Binds to the 23S rRNA
JW297_RS04225	COG1841	ribosomal large subunit assembly
JW297_RS04230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JW297_RS04240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JW297_RS04245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JW297_RS04250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JW297_RS04260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JW297_RS04265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JW297_RS04270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JW297_RS04275	COG0255	Belongs to the universal ribosomal protein uL29 family
JW297_RS04280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JW297_RS04285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JW297_RS04290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JW297_RS04295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JW297_RS04300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JW297_RS04315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JW297_RS04320	COG0051	transcription antitermination factor activity, RNA binding
JW297_RS04360	COG1072	(Pantothenic acid kinase))
JW297_RS04370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JW297_RS04405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JW297_RS04410	COG4206	TonB-dependent receptor
JW297_RS04415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JW297_RS04420	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
JW297_RS04425	COG0310	cobalt ion transport
JW297_RS04430	COG0310	cobalt ion transport
JW297_RS04440	COG1122	ATPase activity
JW297_RS04445	COG2252	PERMEase
JW297_RS04450	COG0765	amino acid transport
JW297_RS04455	COG0765	amino acid transport
JW297_RS04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JW297_RS04470	COG3121	Chaperone
JW297_RS04475	COG3188	usher protein
JW297_RS04495	COG0704	Plays a role in the regulation of phosphate uptake
JW297_RS04505	COG0581	inorganic phosphate transmembrane transporter activity
JW297_RS04510	COG0573	inorganic phosphate transmembrane transporter activity
JW297_RS04515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JW297_RS04530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JW297_RS04535	COG2183	response to ionizing radiation
JW297_RS04540	COG1918	ferrous iron import across plasma membrane
JW297_RS04555	COG0596	Alpha beta hydrolase
JW297_RS04560	COG1040	competence protein
JW297_RS04565	COG0316	Belongs to the HesB IscA family
JW297_RS04565	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JW297_RS04570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JW297_RS04575	COG0705	Rhomboid family
JW297_RS04580	COG1349	DNA-binding transcription factor activity
JW297_RS04585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JW297_RS04600	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JW297_RS04605	COG0028	Belongs to the TPP enzyme family
JW297_RS04610	COG1473	amidohydrolase
JW297_RS04615	COG0583	DNA-binding transcription factor activity
JW297_RS04620	COG1396	sequence-specific DNA binding
JW297_RS04625	COG0477	Major facilitator Superfamily
JW297_RS04645	COG0814	amino acid
JW297_RS04650	COG1396	sequence-specific DNA binding
JW297_RS04655	COG0183	Belongs to the thiolase family
JW297_RS04660	COG2031	fatty acid transporter
JW297_RS04665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JW297_RS04670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JW297_RS04675	COG2204	response regulator
JW297_RS04680	COG3852	Histidine kinase
JW297_RS04685	COG0800	Aldolase
JW297_RS04690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS04695	COG1904	glucuronate isomerase
JW297_RS04700	COG0246	Mannitol dehydrogenase
JW297_RS04715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JW297_RS04725	COG2186	Transcriptional regulator
JW297_RS04730	COG0626	cystathionine gamma-synthase activity
JW297_RS04735	COG1757	Na H antiporter
JW297_RS04740	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JW297_RS04755	COG3188	usher protein
JW297_RS04770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JW297_RS04775	COG3162	membrane
JW297_RS04780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JW297_RS04785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JW297_RS04790	COG2258	MOSC domain
JW297_RS04800	COG3381	protein complex oligomerization
JW297_RS04805	COG3302	dmso reductase anchor subunit
JW297_RS04810	COG0437	4 iron, 4 sulfur cluster binding
JW297_RS04815	COG0243	molybdopterin cofactor binding
JW297_RS04825	COG0180	Tryptophanyl-tRNA synthetase
JW297_RS04830	COG0546	phosphoglycolate phosphatase activity
JW297_RS04835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JW297_RS04845	COG3266	domain, Protein
JW297_RS04850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JW297_RS04860	COG4796	Type ii and iii secretion system protein
JW297_RS04880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JW297_RS04885	COG0494	nUDIX hydrolase
JW297_RS04895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JW297_RS04900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JW297_RS04905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JW297_RS04910	COG1741	Belongs to the pirin family
JW297_RS04915	COG2081	HI0933 family
JW297_RS04920	COG0306	phosphate transporter
JW297_RS04930	COG0589	response to stress
JW297_RS04935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JW297_RS04940	COG0742	ribosomal rna small subunit methyltransferase
JW297_RS04995	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
JW297_RS05000	COG3683	transport system, periplasmic component
JW297_RS05005	COG0840	transmembrane signaling receptor activity
JW297_RS05010	COG0625	glutathione transferase activity
JW297_RS05035	COG2186	Transcriptional regulator
JW297_RS05040	COG0477	Major facilitator Superfamily
JW297_RS05045	COG1609	Transcriptional regulator
JW297_RS05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS05055	COG1879	ABC-type sugar transport system periplasmic component
JW297_RS05060	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW297_RS05065	COG1129	ABC transporter
JW297_RS05070	COG1869	D-ribose catabolic process
JW297_RS05075	COG3397	chitin binding
JW297_RS05085	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JW297_RS05090	COG2502	aspartate--ammonia ligase
JW297_RS05095	COG1522	sequence-specific DNA binding
JW297_RS05100	COG0716	FMN binding
JW297_RS05105	COG0445	tRNA wobble uridine modification
JW297_RS05110	COG0357	Ribosomal RNA small subunit methyltransferase G
JW297_RS05115	COG3312	ion transport
JW297_RS05120	COG0356	it plays a direct role in the translocation of protons across the membrane
JW297_RS05130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JW297_RS05135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JW297_RS05140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JW297_RS05145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JW297_RS05150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JW297_RS05155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JW297_RS05160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JW297_RS05245	COG0840	transmembrane signaling receptor activity
JW297_RS05250	COG0840	transmembrane signaling receptor activity
JW297_RS05265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JW297_RS05270	COG0076	glutamate decarboxylase activity
JW297_RS05275	COG0531	amino acid
JW297_RS05280	COG2066	Belongs to the glutaminase family
JW297_RS05285	COG0531	amino acid
JW297_RS05300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JW297_RS05320	COG0594	ribonuclease P activity
JW297_RS05325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JW297_RS05330	COG0706	membrane insertase activity
JW297_RS05335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JW297_RS05340	COG0697	spore germination
JW297_RS05380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JW297_RS05390	COG0437	4 iron, 4 sulfur cluster binding
JW297_RS05395	COG2864	formate dehydrogenase
JW297_RS05400	COG3058	Necessary for formate dehydrogenase activity
JW297_RS05405	COG1921	L-seryl-tRNASec selenium transferase activity
JW297_RS05410	COG3276	selenocysteine insertion sequence binding
JW297_RS05440	COG0583	DNA-binding transcription factor activity
JW297_RS05455	COG1275	C4-dicarboxylate transporter malic acid transport protein
JW297_RS05460	COG2233	PERMEase
JW297_RS05475	COG1561	YicC-like family, N-terminal region
JW297_RS05480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JW297_RS05485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JW297_RS05490	COG1309	transcriptional regulator
JW297_RS05495	COG0756	dUTP diphosphatase activity
JW297_RS05500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JW297_RS05505	COG2003	Belongs to the UPF0758 family
JW297_RS05510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JW297_RS05515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JW297_RS05520	COG1216	Glycosyl transferase, family 2
JW297_RS05530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JW297_RS05535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JW297_RS05545	COG1519	Transferase
JW297_RS05550	COG0859	PFAM glycosyl transferase family 9
JW297_RS05570	COG0859	PFAM glycosyl transferase family 9
JW297_RS05580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JW297_RS05590	COG2861	carbohydrate metabolic process
JW297_RS05595	COG4942	peptidase
JW297_RS05600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JW297_RS05605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JW297_RS05610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JW297_RS05615	COG1045	serine acetyltransferase
JW297_RS05620	COG3274	enterobacterial common antigen metabolic process
JW297_RS05630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JW297_RS05645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JW297_RS05655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JW297_RS05685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JW297_RS05690	COG1091	dTDP-4-dehydrorhamnose reductase activity
JW297_RS05695	COG2205	protein histidine kinase activity
JW297_RS05700	COG0745	RESPONSE REGULATOR receiver
JW297_RS05770	COG4695	Portal protein
JW297_RS05810	COG3772	lysozyme
JW297_RS05930	COG0205	6-phosphofructokinase activity
JW297_RS05935	COG0149	triose-phosphate isomerase activity
JW297_RS05945	COG3152	Membrane
JW297_RS05955	COG2814	Major facilitator Superfamily
JW297_RS05960	COG0584	glycerophosphoryl diester phosphodiesterase
JW297_RS05965	COG2271	Major facilitator Superfamily
JW297_RS05970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JW297_RS05980	COG3074	FtsZ-dependent cytokinesis
JW297_RS05985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JW297_RS05990	COG1575	Belongs to the MenA family. Type 1 subfamily
JW297_RS05995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JW297_RS06000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JW297_RS06005	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JW297_RS06010	COG1609	Transcriptional regulator
JW297_RS06015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JW297_RS06030	COG0626	cystathionine gamma-synthase activity
JW297_RS06035	COG0460	homoserine dehydrogenase
JW297_RS06035	COG0527	aspartate kinase activity
JW297_RS06040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JW297_RS06065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JW297_RS06070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JW297_RS06075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JW297_RS06080	COG0137	argininosuccinate synthase activity
JW297_RS06085	COG0165	Argininosuccinate lyase
JW297_RS06095	COG0583	DNA-binding transcription factor activity
JW297_RS06100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW297_RS06130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW297_RS06150	COG1217	gtp-binding protein TYPA
JW297_RS06155	COG1011	Hydrolase
JW297_RS06165	COG0456	acetyltransferase
JW297_RS06170	COG2982	Protein involved in outer membrane biogenesis
JW297_RS06175	COG2233	PERMEase
JW297_RS06180	COG0786	glutamate:sodium symporter activity
JW297_RS06185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JW297_RS06190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW297_RS06195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JW297_RS06200	COG1758	RNA polymerase activity
JW297_RS06210	COG2860	membrane
JW297_RS06215	COG0823	Involved in the tonB-independent uptake of proteins
JW297_RS06220	COG5645	(Lipo)protein
JW297_RS06225	COG2818	Glycosylase
JW297_RS06255	COG0747	negative chemotaxis
JW297_RS06260	COG0601	transmembrane transport
JW297_RS06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW297_RS06270	COG0444	Belongs to the ABC transporter superfamily
JW297_RS06275	COG4608	Belongs to the ABC transporter superfamily
JW297_RS06280	COG2199	diguanylate cyclase activity
JW297_RS06280	COG2200	EAL domain
JW297_RS06295	COG1942	4-Oxalocrotonate Tautomerase
JW297_RS06300	COG1295	ribonuclease BN
JW297_RS06310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JW297_RS06315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW297_RS06335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JW297_RS06345	COG0746	molybdenum cofactor guanylyltransferase activity
JW297_RS06350	COG3084	Protein conserved in bacteria
JW297_RS06355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JW297_RS06360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JW297_RS06365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW297_RS06365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW297_RS06370	COG0242	peptide deformylase activity
JW297_RS06375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JW297_RS06380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JW297_RS06390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JW297_RS06405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JW297_RS06410	COG1765	OsmC-like protein
JW297_RS06415	COG3954	Phosphoribulokinase
JW297_RS06420	COG3089	Belongs to the UPF0270 family
JW297_RS06425	COG0429	hydrolase of the alpha beta-hydrolase fold
JW297_RS06435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS06435	COG1263	PTS System
JW297_RS06440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JW297_RS06450	COG0488	(ABC) transporter
JW297_RS06455	COG2249	NAD(P)H dehydrogenase (quinone) activity
JW297_RS06465	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JW297_RS06470	COG1047	Peptidyl-prolyl cis-trans
JW297_RS06475	COG2900	Belongs to the SlyX family
JW297_RS06480	COG0545	Peptidyl-prolyl cis-trans isomerase
JW297_RS06485	COG2964	Protein conserved in bacteria
JW297_RS06505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JW297_RS06510	COG0049	tRNA binding
JW297_RS06515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JW297_RS06530	COG0250	Participates in transcription elongation, termination and antitermination
JW297_RS06535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JW297_RS06540	COG0081	regulation of translation
JW297_RS06545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JW297_RS06555	COG0085	RNA polymerase activity
JW297_RS06560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JW297_RS06565	COG0726	polysaccharide deacetylase
JW297_RS06575	COG0626	cystathionine gamma-synthase activity
JW297_RS06580	COG1115	amino acid carrier protein
JW297_RS06585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JW297_RS06590	COG2022	thiamine diphosphate biosynthetic process
JW297_RS06595	COG2104	thiamine diphosphate biosynthetic process
JW297_RS06600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JW297_RS06605	COG0352	thiamine-phosphate diphosphorylase activity
JW297_RS06610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JW297_RS06615	COG0840	transmembrane signaling receptor activity
JW297_RS06625	COG3842	ATPase activity
JW297_RS06650	COG2816	NAD+ diphosphatase activity
JW297_RS06655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JW297_RS06660	COG1515	deoxyribonuclease V activity
JW297_RS06665	COG3068	Protein conserved in bacteria
JW297_RS06680	COG0151	Belongs to the GarS family
JW297_RS06720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JW297_RS06725	COG0800	Aldolase
JW297_RS06730	COG0129	dihydroxy-acid dehydratase activity
JW297_RS06735	COG1410	methionine synthase
JW297_RS06735	COG0646	methionine synthase
JW297_RS06750	COG0527	aspartate kinase activity
JW297_RS06765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JW297_RS06770	COG2937	Belongs to the GPAT DAPAT family
JW297_RS06775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JW297_RS06780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JW297_RS06785	COG0735	belongs to the Fur family
JW297_RS06790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW297_RS06795	COG1396	sequence-specific DNA binding
JW297_RS06840	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JW297_RS06845	COG5532	Uncharacterized conserved protein (DUF2303)
JW297_RS06910	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
JW297_RS06920	COG1403	HNH endonuclease
JW297_RS06955	COG3772	lysozyme
JW297_RS06995	COG0740	serine-type endopeptidase activity
JW297_RS07110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JW297_RS07135	COG1448	Aminotransferase
JW297_RS07140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JW297_RS07155	COG0028	Belongs to the TPP enzyme family
JW297_RS07160	COG0440	acetolactate synthase activity
JW297_RS07180	COG2252	PERMEase
JW297_RS07185	COG0025	NhaP-type Na H and K H
JW297_RS07195	COG0583	DNA-binding transcription factor activity
JW297_RS07200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JW297_RS07205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JW297_RS07210	COG1690	Belongs to the RtcB family
JW297_RS07220	COG2365	Tyrosine phosphatase family
JW297_RS07225	COG0586	Pfam SNARE associated Golgi protein
JW297_RS07230	COG1322	Protein conserved in bacteria
JW297_RS07235	COG2226	methyltransferase
JW297_RS07245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JW297_RS07250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JW297_RS07255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JW297_RS07260	COG0805	protein transport
JW297_RS07275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JW297_RS07285	COG0183	Belongs to the thiolase family
JW297_RS07295	COG0006	proline dipeptidase activity
JW297_RS07300	COG1739	Uncharacterized protein family UPF0029
JW297_RS07305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JW297_RS07310	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
JW297_RS07345	COG1472	Belongs to the glycosyl hydrolase 3 family
JW297_RS07355	COG0583	DNA-binding transcription factor activity
JW297_RS07360	COG1124	(ABC) transporter
JW297_RS07375	COG1283	sodium-dependent phosphate transmembrane transporter activity
JW297_RS07400	COG2813	Specifically methylates the guanine in position
JW297_RS07405	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
JW297_RS07420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JW297_RS07430	COG4667	esterase of the alpha-beta hydrolase superfamily
JW297_RS07435	COG0084	hydrolase, TatD family'
JW297_RS07440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JW297_RS07445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JW297_RS07450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JW297_RS07455	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JW297_RS07465	COG0612	Peptidase, M16
JW297_RS07470	COG4178	(ABC) transporter
JW297_RS07475	COG4771	TonB-dependent receptor
JW297_RS07485	COG1595	DNA-templated transcription, initiation
JW297_RS07505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW297_RS07510	COG4172	Belongs to the ABC transporter superfamily
JW297_RS07520	COG0832	Belongs to the urease beta subunit family
JW297_RS07525	COG0804	urea catabolic process
JW297_RS07540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JW297_RS07550	COG4413	Urea transporter
JW297_RS07555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JW297_RS07560	COG1289	transmembrane transporter activity
JW297_RS07565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JW297_RS07570	COG3726	membrane protein affecting hemolysin expression
JW297_RS07575	COG0560	Phosphoserine phosphatase
JW297_RS07580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JW297_RS07590	COG0488	(ABC) transporter
JW297_RS07600	COG0741	lytic transglycosylase activity
JW297_RS07605	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JW297_RS07620	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JW297_RS07625	COG0406	alpha-ribazole phosphatase activity
JW297_RS07630	COG2207	Transcriptional regulator
JW297_RS07630	COG3708	Transcriptional regulator
JW297_RS07635	COG3045	CreA protein
JW297_RS07640	COG0745	RESPONSE REGULATOR receiver
JW297_RS07655	COG0083	homoserine kinase activity
JW297_RS07670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JW297_RS07675	COG0521	Mo-molybdopterin cofactor biosynthetic process
JW297_RS07690	COG0443	Heat shock 70 kDa protein
JW297_RS07695	COG0484	heat shock protein binding
JW297_RS07705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JW297_RS07710	COG0583	DNA-binding transcription factor activity
JW297_RS07715	COG0268	Binds directly to 16S ribosomal RNA
JW297_RS07720	COG0196	riboflavin kinase activity
JW297_RS07725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JW297_RS07730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JW297_RS07735	COG1047	Peptidyl-prolyl cis-trans
JW297_RS07740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JW297_RS07750	COG0505	Belongs to the CarA family
JW297_RS07760	COG5295	Hep Hag repeat protein
JW297_RS07760	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JW297_RS07770	COG1979	alcohol dehydrogenase
JW297_RS07775	COG0586	Pfam SNARE associated Golgi protein
JW297_RS07785	COG0848	biopolymer transport protein
JW297_RS07795	COG4991	sh3 domain protein
JW297_RS07800	COG3025	triphosphatase activity
JW297_RS07805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JW297_RS07810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JW297_RS07810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JW297_RS07820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JW297_RS07825	COG3384	dioxygenase
JW297_RS07830	COG0754	glutathionylspermidine amidase activity
JW297_RS07845	COG0494	nUDIX hydrolase
JW297_RS07850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JW297_RS07855	COG3150	esterase
JW297_RS07870	COG0204	Acyl-transferase
JW297_RS07875	COG2132	Multicopper oxidase
JW297_RS07885	COG1280	lysine exporter protein (LysE YggA)
JW297_RS07895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JW297_RS07905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JW297_RS07910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JW297_RS07915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW297_RS07920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JW297_RS07925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JW297_RS07930	COG0564	pseudouridine synthase activity
JW297_RS07935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JW297_RS07940	COG0417	DNA replication proofreading
JW297_RS07945	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JW297_RS07950	COG1178	ABC-type Fe3 transport system permease component
JW297_RS07955	COG4143	(ABC) transporter
JW297_RS07960	COG0494	nUDIX hydrolase
JW297_RS07970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JW297_RS07975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JW297_RS07985	COG4795	General secretion pathway protein
JW297_RS08000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JW297_RS08010	COG1074	ATP-dependent DNA helicase activity
JW297_RS08015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JW297_RS08020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JW297_RS08020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JW297_RS08025	COG0860	N-Acetylmuramoyl-L-alanine amidase
JW297_RS08045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JW297_RS08050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JW297_RS08055	COG2166	iron-sulfur cluster assembly
JW297_RS08060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JW297_RS08065	COG0583	DNA-binding transcription factor activity
JW297_RS08070	COG2363	Small membrane protein
JW297_RS08085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW297_RS08090	COG1611	Belongs to the LOG family
JW297_RS08105	COG3098	single-species biofilm formation
JW297_RS08110	COG0564	pseudouridine synthase activity
JW297_RS08115	COG0716	FMN binding
JW297_RS08130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JW297_RS08145	COG0052	Belongs to the universal ribosomal protein uS2 family
JW297_RS08150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JW297_RS08155	COG0528	UMP kinase activity
JW297_RS08160	COG0233	cytoplasmic translational termination
JW297_RS08170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JW297_RS08175	COG0575	Belongs to the CDS family
JW297_RS08185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW297_RS08195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW297_RS08200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JW297_RS08205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW297_RS08210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JW297_RS08215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JW297_RS08225	COG0825	malonyl-CoA metabolic process
JW297_RS08230	COG0037	tRNA processing
JW297_RS08235	COG4568	rho-dependent transcription termination
JW297_RS08240	COG3015	lipoprotein NlpE involved in copper resistance
JW297_RS08245	COG0442	prolyl-tRNA aminoacylation
JW297_RS08250	COG1720	tRNA m6t6A37 methyltransferase activity
JW297_RS08260	COG1464	Belongs to the NlpA lipoprotein family
JW297_RS08270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JW297_RS08275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JW297_RS08300	COG3021	interspecies interaction between organisms
JW297_RS08320	COG0602	queuosine metabolic process
JW297_RS08325	COG0720	synthase
JW297_RS08330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JW297_RS08340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JW297_RS08345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JW297_RS08350	COG0585	pseudouridine synthase activity
JW297_RS08360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JW297_RS08365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JW297_RS08370	COG4942	peptidase
JW297_RS08370	COG1388	LysM domain
JW297_RS08380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JW297_RS08415	COG0471	metal ion transport
JW297_RS08445	COG1301	dicarboxylic acid transport
JW297_RS08450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JW297_RS08450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JW297_RS08460	COG0501	Belongs to the peptidase M48B family
JW297_RS08465	COG0583	DNA-binding transcription factor activity
JW297_RS08475	COG0588	phosphoglycerate mutase activity
JW297_RS08485	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
JW297_RS08490	COG1492	cobalamin metabolic process
JW297_RS08555	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JW297_RS08575	COG1648	precorrin-2 dehydrogenase activity
JW297_RS08575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JW297_RS08595	COG1648	precorrin-2 dehydrogenase activity
JW297_RS08595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JW297_RS08600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JW297_RS08610	COG4865	methylaspartate mutase activity
JW297_RS08615	COG3799	methylaspartate ammonia-lyase activity
JW297_RS08630	COG1301	dicarboxylic acid transport
JW297_RS08640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW297_RS08650	COG1082	Xylose isomerase domain protein TIM barrel
JW297_RS08655	COG2188	Transcriptional regulator
JW297_RS08665	COG4810	utilization protein
JW297_RS08680	COG4812	Cobalamin adenosyltransferase
JW297_RS08685	COG0280	phosphate acetyltransferase
JW297_RS08695	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
JW297_RS08705	COG4820	ethanolamine utilization protein (EutJ)
JW297_RS08720	COG4819	ethanolamine utilization protein
JW297_RS08725	COG4303	Ethanolamine ammonia lyase large subunit
JW297_RS08735	COG4816	utilization protein
JW297_RS08740	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
JW297_RS08745	COG4656	Part of a membrane complex involved in electron transport
JW297_RS08760	COG0252	asparaginase activity
JW297_RS08795	COG2252	PERMEase
JW297_RS08800	COG0402	S-adenosylhomocysteine deaminase activity
JW297_RS08805	COG2080	2 iron, 2 sulfur cluster binding
JW297_RS08805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JW297_RS08810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JW297_RS08815	COG0402	S-adenosylhomocysteine deaminase activity
JW297_RS08820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW297_RS08820	COG0493	'glutamate synthase
JW297_RS08825	COG2068	MobA-Related Protein
JW297_RS08830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JW297_RS08835	COG3608	succinylglutamate desuccinylase aspartoacylase
JW297_RS08835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JW297_RS08840	COG1914	H( )-stimulated, divalent metal cation uptake system
JW297_RS08850	COG0668	transmembrane transport
JW297_RS08875	COG0477	Major facilitator Superfamily
JW297_RS08885	COG0549	Belongs to the carbamate kinase family
JW297_RS08895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JW297_RS08900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JW297_RS08905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JW297_RS08910	COG3829	transcription factor binding
JW297_RS08920	COG1733	regulation of RNA biosynthetic process
JW297_RS08925	COG2080	2 iron, 2 sulfur cluster binding
JW297_RS08930	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JW297_RS08935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JW297_RS08950	COG4566	intracellular signal transduction
JW297_RS08960	COG2962	Rard protein
JW297_RS08980	COG1966	Carbon starvation protein
JW297_RS08985	COG0523	cobalamin synthesis protein
JW297_RS08995	COG0534	Mate efflux family protein
JW297_RS09000	COG0673	inositol 2-dehydrogenase activity
JW297_RS09010	COG3033	Beta-eliminating lyase
JW297_RS09015	COG0814	amino acid
JW297_RS09020	COG5564	TIM-barrel signal transduction protein
JW297_RS09025	COG5441	Belongs to the UPF0261 family
JW297_RS09050	COG3842	ATPase activity
JW297_RS09060	COG1840	ABC-type Fe3 transport system, periplasmic component
JW297_RS09065	COG2271	Major facilitator Superfamily
JW297_RS09095	COG0288	reversible hydration of carbon dioxide
JW297_RS09100	COG1131	(ABC) transporter
JW297_RS09105	COG0842	Transport permease protein
JW297_RS09135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JW297_RS09140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JW297_RS09160	COG1489	DNA binding
JW297_RS09165	COG1643	Atp-dependent helicase
JW297_RS09170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JW297_RS09210	COG2864	formate dehydrogenase
JW297_RS09215	COG0437	4 iron, 4 sulfur cluster binding
JW297_RS09230	COG0243	molybdopterin cofactor binding
JW297_RS09235	COG0437	4 iron, 4 sulfur cluster binding
JW297_RS09245	COG3381	protein complex oligomerization
JW297_RS09255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JW297_RS09260	COG0316	Belongs to the HesB IscA family
JW297_RS09275	COG0243	molybdopterin cofactor binding
JW297_RS09280	COG0437	4 iron, 4 sulfur cluster binding
JW297_RS09300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JW297_RS09305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JW297_RS09315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JW297_RS09320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JW297_RS09325	COG3956	TIGRFAM MazG family protein
JW297_RS09330	COG0504	CTP synthase activity
JW297_RS09335	COG0148	phosphopyruvate hydratase activity
JW297_RS09340	COG0471	metal ion transport
JW297_RS09345	COG1388	LysM domain
JW297_RS09345	COG0741	lytic transglycosylase activity
JW297_RS09350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JW297_RS09355	COG2226	methyltransferase
JW297_RS09360	COG0328	RNA-DNA hybrid ribonuclease activity
JW297_RS09365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JW297_RS09380	COG2233	PERMEase
JW297_RS09385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JW297_RS09390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JW297_RS09415	COG1358	cellular component organization or biogenesis
JW297_RS09475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JW297_RS09485	COG1846	Transcriptional regulator
JW297_RS09490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JW297_RS09505	COG1349	DNA-binding transcription factor activity
JW297_RS09510	COG0561	phosphatase activity
JW297_RS09515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JW297_RS09525	COG1304	FMN binding
JW297_RS09530	COG1620	l-lactate permease
JW297_RS09565	COG2211	Major facilitator Superfamily
JW297_RS09570	COG0583	DNA-binding transcription factor activity
JW297_RS09625	COG1840	ABC-type Fe3 transport system, periplasmic component
JW297_RS09630	COG0395	ABC-type sugar transport system, permease component
JW297_RS09635	COG3842	ATPase activity
JW297_RS09645	COG0500	methyltransferase
JW297_RS09650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JW297_RS09655	COG1737	Transcriptional regulator
JW297_RS09660	COG2731	YhcH YjgK YiaL family protein
JW297_RS09665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JW297_RS09675	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JW297_RS09680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JW297_RS09705	COG0305	Participates in initiation and elongation during chromosome replication
JW297_RS09745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JW297_RS09770	COG1982	Orn Lys Arg decarboxylase major
JW297_RS09795	COG3059	membrane
JW297_RS09870	COG2375	cellular response to nickel ion
JW297_RS09870	COG1132	(ABC) transporter
JW297_RS09890	COG2226	methyltransferase
JW297_RS09890	COG3433	isochorismatase activity
JW297_RS09890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JW297_RS09900	COG2814	Major facilitator Superfamily
JW297_RS09905	COG4771	TonB-dependent receptor
JW297_RS10125	COG0741	lytic transglycosylase activity
JW297_RS10130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JW297_RS10135	COG1194	a g-specific adenine glycosylase
JW297_RS10145	COG3171	Protein conserved in bacteria
JW297_RS10150	COG2066	Belongs to the glutaminase family
JW297_RS10160	COG4607	ABC-type enterochelin transport system periplasmic component
JW297_RS10165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW297_RS10170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JW297_RS10175	COG0762	integral membrane protein
JW297_RS10180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JW297_RS10185	COG2805	Type II/IV secretion system protein
JW297_RS10190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JW297_RS10195	COG1678	Uncharacterized ACR, COG1678
JW297_RS10200	COG0189	ligase activity
JW297_RS10205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JW297_RS10225	COG0583	DNA-binding transcription factor activity
JW297_RS10230	COG0583	DNA-binding transcription factor activity
JW297_RS10240	COG1902	pentaerythritol trinitrate reductase activity
JW297_RS10250	COG1960	acyl-CoA dehydrogenase activity
JW297_RS10260	COG0121	glutamine amidotransferase
JW297_RS10265	COG3034	peptidoglycan biosynthetic process
JW297_RS10270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JW297_RS10275	COG1805	sodium ion transport
JW297_RS10280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JW297_RS10285	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JW297_RS10290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JW297_RS10295	COG2871	sodium ion transport
JW297_RS10300	COG1477	protein flavinylation
JW297_RS10305	COG2991	Protein conserved in bacteria
JW297_RS10320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JW297_RS10325	COG2195	Cleaves the N-terminal amino acid of tripeptides
JW297_RS10330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JW297_RS10335	COG1073	alpha beta
JW297_RS10345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JW297_RS10350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JW297_RS10355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JW297_RS10370	COG1546	Belongs to the CinA family
JW297_RS10375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JW297_RS10380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JW297_RS10385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JW297_RS10415	COG2918	glutathione biosynthetic process
JW297_RS10425	COG4536	flavin adenine dinucleotide binding
JW297_RS10430	COG4137	Cytochrome C assembly protein
JW297_RS10435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JW297_RS10450	COG0336	Belongs to the RNA methyltransferase TrmD family
JW297_RS10455	COG0335	large ribosomal subunit rRNA binding
JW297_RS10460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JW297_RS10465	COG1605	Chorismate mutase
JW297_RS10465	COG0287	Prephenate dehydrogenase
JW297_RS10475	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JW297_RS10480	COG0077	Prephenate dehydratase
JW297_RS10480	COG1605	Chorismate mutase
JW297_RS10485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JW297_RS10490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW297_RS10505	COG0542	response to heat
JW297_RS10550	COG5544	Lipoprotein
JW297_RS10555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JW297_RS10560	COG1042	CoA-binding domain protein
JW297_RS10560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW297_RS10560	COG0045	succinate-CoA ligase (ADP-forming) activity
JW297_RS10565	COG3148	PFAM DTW domain containing protein
JW297_RS10570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW297_RS10575	COG2814	Major facilitator Superfamily
JW297_RS10580	COG1566	PFAM secretion protein HlyD family protein
JW297_RS10585	COG1846	Transcriptional regulator
JW297_RS10590	COG2814	Major facilitator Superfamily
JW297_RS10595	COG2113	Glycine betaine
JW297_RS10600	COG4176	ABC-type proline glycine betaine transport system permease component
JW297_RS10605	COG4175	Glycine betaine
JW297_RS10625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JW297_RS10630	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JW297_RS10635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JW297_RS10640	COG1278	Cold shock
JW297_RS10645	COG0697	spore germination
JW297_RS10650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JW297_RS10660	COG2921	Belongs to the UPF0250 family
JW297_RS10665	COG1686	Belongs to the peptidase S11 family
JW297_RS10670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JW297_RS10675	COG0772	Belongs to the SEDS family
JW297_RS10680	COG0768	penicillin binding
JW297_RS10685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JW297_RS10690	COG0799	negative regulation of ribosome biogenesis
JW297_RS10700	COG1733	regulation of RNA biosynthetic process
JW297_RS10705	COG4221	oxidoreductase activity
JW297_RS10715	COG1466	dna polymerase III delta subunit
JW297_RS10720	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JW297_RS10725	COG0495	leucyl-tRNA aminoacylation
JW297_RS10730	COG1126	abc transporter atp-binding protein
JW297_RS10735	COG0765	amino acid transport
JW297_RS10740	COG0765	amino acid transport
JW297_RS10755	COG4232	protein-disulfide reductase activity
JW297_RS10765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JW297_RS10770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JW297_RS10780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JW297_RS10785	COG1702	phosphate starvation-inducible protein PhoH
JW297_RS10790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JW297_RS10795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JW297_RS10835	COG1846	Transcriptional regulator
JW297_RS10835	COG1940	carbohydrate kinase activity
JW297_RS10840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JW297_RS10845	COG0363	glucosamine-6-phosphate deaminase activity
JW297_RS10850	COG2190	(PTS) system
JW297_RS10850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS10850	COG1263	PTS System
JW297_RS10855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JW297_RS10860	COG0735	belongs to the Fur family
JW297_RS10865	COG0716	FMN binding
JW297_RS10880	COG0596	Alpha beta hydrolase
JW297_RS10885	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JW297_RS10890	COG0033	Phosphoglucomutase
JW297_RS10905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JW297_RS10910	COG2814	Major facilitator Superfamily
JW297_RS10920	COG0372	Belongs to the citrate synthase family
JW297_RS10930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JW297_RS10935	COG1053	succinate dehydrogenase
JW297_RS10945	COG0567	Dehydrogenase, E1 component
JW297_RS10950	COG0508	dehydrogenase complex catalyzes the overall conversion of
JW297_RS10955	COG0045	succinate-CoA ligase (ADP-forming) activity
JW297_RS10960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JW297_RS10965	COG1271	oxidase subunit
JW297_RS10970	COG1294	oxidase, subunit
JW297_RS10975	COG4890	Cyd operon protein YbgT
JW297_RS10980	COG3790	cyd operon protein YbgE
JW297_RS10985	COG0583	DNA-binding transcription factor activity
JW297_RS10990	COG2814	Major facilitator Superfamily
JW297_RS11000	COG0824	Thioesterase
JW297_RS11005	COG0811	peptide transport
JW297_RS11010	COG0848	biopolymer transport protein
JW297_RS11015	COG3064	Membrane
JW297_RS11015	COG3064	Membrane
JW297_RS11020	COG0823	Involved in the tonB-independent uptake of proteins
JW297_RS11025	COG2885	chlorophyll binding
JW297_RS11030	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JW297_RS11060	COG2354	Protein conserved in bacteria
JW297_RS11065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JW297_RS11070	COG0588	phosphoglycerate mutase activity
JW297_RS11080	COG1119	ATPase activity
JW297_RS11090	COG3585	molybdate ion transport
JW297_RS11090	COG2005	Transcriptional regulator
JW297_RS11105	COG0725	ABC transporter, periplasmic molybdate-binding protein
JW297_RS11110	COG4149	molybdate abc transporter
JW297_RS11115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JW297_RS11125	COG0561	phosphatase activity
JW297_RS11130	COG2706	6-phosphogluconolactonase activity
JW297_RS11140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JW297_RS11150	COG2226	methyltransferase
JW297_RS11155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JW297_RS11160	COG0556	nucleotide-excision repair
JW297_RS11175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JW297_RS11185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JW297_RS11190	COG0314	molybdopterin synthase activity
JW297_RS11195	COG0670	Belongs to the BI1 family
JW297_RS11200	COG0842	Transport permease protein
JW297_RS11205	COG0842	Transport permease protein
JW297_RS11210	COG1131	(ABC) transporter
JW297_RS11220	COG1309	transcriptional regulator
JW297_RS11225	COG0513	Belongs to the DEAD box helicase family
JW297_RS11230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JW297_RS11235	COG2261	transglycosylase associated protein
JW297_RS11240	COG2897	thiosulfate sulfurtransferase activity
JW297_RS11275	COG5006	permease, DMT superfamily
JW297_RS11295	COG0531	amino acid
JW297_RS11300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JW297_RS11305	COG0402	S-adenosylhomocysteine deaminase activity
JW297_RS11310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JW297_RS11315	COG0303	'Molybdopterin
JW297_RS11320	COG0477	Major facilitator Superfamily
JW297_RS11330	COG0302	gtp cyclohydrolase
JW297_RS11335	COG2311	Membrane
JW297_RS11340	COG2949	membrane
JW297_RS11345	COG0281	malic enzyme
JW297_RS11355	COG1346	cytolysis
JW297_RS11360	COG1380	Effector of murein hydrolase LrgA
JW297_RS11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW297_RS11365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW297_RS11370	COG0489	protein tyrosine kinase activity
JW297_RS11375	COG0572	uridine kinase
JW297_RS11380	COG0717	Belongs to the dCTP deaminase family
JW297_RS11385	COG2982	Protein involved in outer membrane biogenesis
JW297_RS11390	COG3069	C4-dicarboxylate transmembrane transporter activity
JW297_RS11395	COG0307	riboflavin synthase, alpha
JW297_RS11410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JW297_RS11425	COG0025	NhaP-type Na H and K H
JW297_RS11435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW297_RS11440	COG0140	phosphoribosyl-ATP diphosphatase activity
JW297_RS11440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JW297_RS11455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JW297_RS11460	COG0131	Imidazoleglycerol-phosphate dehydratase
JW297_RS11460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JW297_RS11465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JW297_RS11465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JW297_RS11470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JW297_RS11475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JW297_RS11485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JW297_RS11490	COG0625	glutathione transferase activity
JW297_RS11495	COG1686	Belongs to the peptidase S11 family
JW297_RS11505	COG1760	l-serine dehydratase
JW297_RS11510	COG0814	amino acid
JW297_RS11515	COG0814	amino acid
JW297_RS11520	COG0671	phosphoesterase, PA-phosphatase related
JW297_RS11540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JW297_RS11545	COG4160	amino acid transport
JW297_RS11550	COG4215	(ABC) transporter
JW297_RS11555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JW297_RS11560	COG1126	abc transporter atp-binding protein
JW297_RS11565	COG0702	epimerase
JW297_RS11570	COG2431	L-lysine efflux transmembrane transporter activity
JW297_RS11575	COG3593	DNA synthesis involved in DNA repair
JW297_RS11580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW297_RS11585	COG1136	(ABC) transporter
JW297_RS11585	COG0577	efflux transmembrane transporter activity
JW297_RS11590	COG1278	Cold shock
JW297_RS11595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JW297_RS11600	COG0542	response to heat
JW297_RS11605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JW297_RS11610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JW297_RS11615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JW297_RS11625	COG0492	ferredoxin-NADP+ reductase activity
JW297_RS11630	COG1522	sequence-specific DNA binding
JW297_RS11635	COG1674	ftsk spoiiie
JW297_RS11635	COG3107	peptidoglycan biosynthetic process
JW297_RS11640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JW297_RS11645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JW297_RS11650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JW297_RS11660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JW297_RS11665	COG1882	Formate acetyltransferase
JW297_RS11670	COG2116	formate transmembrane transporter activity
JW297_RS11675	COG1944	ATP diphosphatase activity
JW297_RS11680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JW297_RS11685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JW297_RS11690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JW297_RS11695	COG0539	negative regulation of cytoplasmic translation
JW297_RS11705	COG2333	competence protein COMEC
JW297_RS11705	COG0658	competence protein
JW297_RS11715	COG1663	tetraacyldisaccharide 4'-kinase activity
JW297_RS11720	COG1278	Cold shock
JW297_RS11725	COG2835	tetraacyldisaccharide 4'-kinase activity
JW297_RS11730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JW297_RS11735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JW297_RS11740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JW297_RS11745	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JW297_RS11750	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JW297_RS11755	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JW297_RS11770	COG2989	Protein conserved in bacteria
JW297_RS11775	COG3108	Peptidase M15
JW297_RS11780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JW297_RS11785	COG1448	Aminotransferase
JW297_RS11790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JW297_RS11800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JW297_RS11805	COG0308	aminopeptidase N
JW297_RS11810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JW297_RS11815	COG0167	dihydroorotate dehydrogenase activity
JW297_RS11825	COG3217	Mosc domain protein beta barrel domain protein
JW297_RS11825	COG0633	Ferredoxin
JW297_RS11830	COG0116	Belongs to the methyltransferase superfamily
JW297_RS11830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JW297_RS11835	COG0488	(ABC) transporter
JW297_RS11840	COG2995	paraquat-inducible protein a
JW297_RS11845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JW297_RS11845	COG3008	intermembrane lipid transfer
JW297_RS11855	COG3130	regulation of translation
JW297_RS11865	COG1067	ATP-dependent peptidase activity
JW297_RS11870	COG3120	sequence-specific DNA binding
JW297_RS11890	COG1289	transmembrane transporter activity
JW297_RS11895	COG0210	DNA helicase
JW297_RS11900	COG1803	Methylglyoxal synthase
JW297_RS11905	COG1832	CoA-binding protein
JW297_RS11910	COG3785	DNA binding
JW297_RS11915	COG1254	Belongs to the acylphosphatase family
JW297_RS11920	COG2920	part of a sulfur-relay system
JW297_RS11930	COG0582	viral genome integration into host DNA
JW297_RS12080	COG3772	lysozyme
JW297_RS12105	COG1802	Transcriptional regulator
JW297_RS12105	COG4626	Terminase
JW297_RS12115	COG4695	Portal protein
JW297_RS12245	COG3383	formate dehydrogenase (NAD+) activity
JW297_RS12250	COG2391	methyltransferase activity
JW297_RS12255	COG0425	Belongs to the sulfur carrier protein TusA family
JW297_RS12265	COG1811	Na channel or pump
JW297_RS12275	COG2388	GCN5-related N-acetyl-transferase
JW297_RS12285	COG3615	Tellurite resistance protein tehB
JW297_RS12300	COG3539	Fimbrial protein
JW297_RS12310	COG3188	usher protein
JW297_RS12350	COG3539	Fimbrial protein
JW297_RS12365	COG2207	Transcriptional regulator
JW297_RS12365	COG3708	Transcriptional regulator
JW297_RS12390	COG1982	Orn Lys Arg decarboxylase major
JW297_RS12400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JW297_RS12405	COG0583	DNA-binding transcription factor activity
JW297_RS12410	COG0583	DNA-binding transcription factor activity
JW297_RS12440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JW297_RS12455	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JW297_RS12460	COG1924	4 iron, 4 sulfur cluster binding
JW297_RS12470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JW297_RS12470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW297_RS12470	COG1013	pyruvate-flavodoxin oxidoreductase activity
JW297_RS12470	COG0674	pyruvate-flavodoxin oxidoreductase activity
JW297_RS12490	COG1683	Conserved Protein
JW297_RS12495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JW297_RS12505	COG1953	Uracil, thiamine, allantoin
JW297_RS12525	COG1247	-acetyltransferase
JW297_RS12535	COG2914	Belongs to the UPF0125 (RnfH) family
JW297_RS12540	COG2867	negative regulation of translational initiation
JW297_RS12570	COG3196	Protein conserved in bacteria
JW297_RS12575	COG1414	Transcriptional regulator
JW297_RS12580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JW297_RS12585	COG2271	Major facilitator Superfamily
JW297_RS12590	COG2721	sulfolactate sulfo-lyase activity
JW297_RS12595	COG0477	Major facilitator Superfamily
JW297_RS12600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW297_RS12605	COG0497	DNA recombination
JW297_RS12610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JW297_RS12615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JW297_RS12620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JW297_RS12625	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JW297_RS12635	COG0513	Belongs to the DEAD box helicase family
JW297_RS12640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JW297_RS12655	COG3026	antisigma factor binding
JW297_RS12660	COG3086	response to oxidative stress
JW297_RS12680	COG0681	Belongs to the peptidase S26 family
JW297_RS12685	COG0571	ribonuclease III activity
JW297_RS12690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JW297_RS12700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JW297_RS12710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW297_RS12735	COG3157	Type VI secretion system effector, Hcp
JW297_RS12840	COG0024	Methionine aminopeptidase
JW297_RS12845	COG1309	transcriptional regulator
JW297_RS12850	COG0477	Major facilitator Superfamily
JW297_RS12865	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JW297_RS12870	COG0047	phosphoribosylformylglycinamidine synthase activity
JW297_RS12870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JW297_RS12875	COG4771	TonB-dependent receptor
JW297_RS12880	COG4178	(ABC) transporter
JW297_RS12885	COG0612	Peptidase, M16
JW297_RS12895	COG2205	protein histidine kinase activity
JW297_RS12900	COG3170	Tfp pilus assembly protein FimV
JW297_RS12905	COG2204	response regulator
JW297_RS12910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JW297_RS12910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JW297_RS12915	COG0347	Belongs to the P(II) protein family
JW297_RS12925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JW297_RS12925	COG1017	nitric oxide dioxygenase activity
JW297_RS12930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JW297_RS12935	COG2814	Major facilitator Superfamily
JW297_RS12945	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JW297_RS12950	COG1959	2 iron, 2 sulfur cluster binding
JW297_RS12955	COG1104	cysteine desulfurase activity
JW297_RS12960	COG0822	iron-sulfur transferase activity
JW297_RS12965	COG0316	Belongs to the HesB IscA family
JW297_RS12970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JW297_RS12975	COG0443	Heat shock 70 kDa protein
JW297_RS12980	COG0633	Ferredoxin
JW297_RS12985	COG2975	iron-sulfur cluster assembly
JW297_RS12990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JW297_RS13000	COG2373	Large extracellular alpha-helical protein
JW297_RS13005	COG4953	penicillin-binding protein 1C
JW297_RS13010	COG0105	UTP biosynthetic process
JW297_RS13015	COG0589	response to stress
JW297_RS13020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JW297_RS13040	COG0124	histidyl-tRNA synthetase
JW297_RS13045	COG2976	Protein conserved in bacteria
JW297_RS13050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JW297_RS13055	COG1160	GTP binding
JW297_RS13085	COG2837	iron assimilation
JW297_RS13090	COG4150	thiosulfate binding
JW297_RS13100	COG4208	sulfate ABC transporter
JW297_RS13105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JW297_RS13110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JW297_RS13115	COG0519	Catalyzes the synthesis of GMP from XMP
JW297_RS13130	COG0727	PFAM Uncharacterised protein family (UPF0153)
JW297_RS13135	COG2207	Transcriptional regulator
JW297_RS13140	COG2249	NAD(P)H dehydrogenase (quinone) activity
JW297_RS13155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW297_RS13155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW297_RS13160	COG2207	Transcriptional regulator
JW297_RS13170	COG2814	Major facilitator Superfamily
JW297_RS13175	COG1560	Kdo2-lipid A biosynthetic process
JW297_RS13210	COG0418	dihydroorotase activity
JW297_RS13220	COG1396	sequence-specific DNA binding
JW297_RS13290	COG0835	chemotaxis
JW297_RS13300	COG0840	transmembrane signaling receptor activity
JW297_RS13305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JW297_RS13310	COG2201	protein-glutamate methylesterase activity
JW297_RS13315	COG0745	RESPONSE REGULATOR receiver
JW297_RS13330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JW297_RS13365	COG1815	bacterial-type flagellum-dependent cell motility
JW297_RS13370	COG1558	bacterial-type flagellum-dependent cell motility
JW297_RS13375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JW297_RS13390	COG4786	Flagellar basal body rod
JW297_RS13395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JW297_RS13400	COG1706	bacterial-type flagellum-dependent cell motility
JW297_RS13410	COG1256	bacterial-type flagellum assembly
JW297_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
JW297_RS13435	COG1987	bacterial-type flagellum assembly
JW297_RS13440	COG1338	Plays a role in the flagellum-specific transport system
JW297_RS13460	COG1580	Controls the rotational direction of flagella during chemotaxis
JW297_RS13465	COG3144	bacterial-type flagellum assembly
JW297_RS13470	COG2882	bacterial-type flagellum organization
JW297_RS13475	COG1157	protein secretion by the type III secretion system
JW297_RS13480	COG1317	bacterial-type flagellum organization
JW297_RS13485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JW297_RS13490	COG1766	The M ring may be actively involved in energy transduction
JW297_RS13495	COG1677	Flagellar hook-basal body complex protein FliE
JW297_RS13515	COG3042	response to heat
JW297_RS13560	COG1191	sigma factor activity
JW297_RS13570	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JW297_RS13570	COG0506	proline dehydrogenase activity
JW297_RS13570	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JW297_RS13575	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JW297_RS13575	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JW297_RS13575	COG0506	proline dehydrogenase activity
JW297_RS13585	COG1113	amino acid transport
JW297_RS13595	COG1216	Glycosyl transferase, family 2
JW297_RS13600	COG2194	sulfuric ester hydrolase activity
JW297_RS13610	COG2252	PERMEase
JW297_RS13625	COG0765	amino acid transport
JW297_RS13640	COG4589	Belongs to the CDS family
JW297_RS13655	COG0626	cystathionine gamma-synthase activity
JW297_RS13660	COG0814	amino acid
JW297_RS13665	COG0633	Ferredoxin
JW297_RS13670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JW297_RS13675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JW297_RS13680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JW297_RS13690	COG2205	protein histidine kinase activity
JW297_RS13690	COG0784	Response regulator, receiver
JW297_RS13695	COG2197	response regulator
JW297_RS13700	COG0642	Histidine kinase
JW297_RS13700	COG2198	Histidine kinase
JW297_RS13715	COG0582	viral genome integration into host DNA
JW297_RS13720	COG0629	single-stranded DNA binding
JW297_RS13800	COG1484	DNA-dependent DNA replication
JW297_RS13840	COG1278	Cold shock
JW297_RS13845	COG1560	Kdo2-lipid A biosynthetic process
JW297_RS13860	COG0071	Belongs to the small heat shock protein (HSP20) family
JW297_RS13875	COG3772	lysozyme
JW297_RS13900	COG5484	DNA packaging
JW297_RS13900	COG3728	DNA packaging
JW297_RS14025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JW297_RS14035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JW297_RS14040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JW297_RS14150	COG3738	Protein conserved in bacteria
JW297_RS14165	COG2207	Transcriptional regulator
JW297_RS14165	COG3708	Transcriptional regulator
JW297_RS14190	COG0668	transmembrane transport
JW297_RS14195	COG3247	response to pH
JW297_RS14235	COG0321	lipoyl(octanoyl) transferase activity
JW297_RS14235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JW297_RS14245	COG1770	oligopeptidase
JW297_RS14250	COG1570	exodeoxyribonuclease VII activity
JW297_RS14255	COG0516	GMP reductase activity
JW297_RS14255	COG0517	IMP dehydrogenase activity
JW297_RS14260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JW297_RS14260	COG0519	Catalyzes the synthesis of GMP from XMP
JW297_RS14265	COG0582	viral genome integration into host DNA
JW297_RS14365	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
JW297_RS14505	COG1335	isochorismatase
JW297_RS14515	COG2814	Major facilitator Superfamily
JW297_RS14525	COG0823	Involved in the tonB-independent uptake of proteins
JW297_RS14545	COG2226	methyltransferase
JW297_RS14550	COG1971	Probably functions as a manganese efflux pump
JW297_RS14555	COG4811	Protein of unknown function (DUF986)
JW297_RS14560	COG3716	PTS system mannose fructose sorbose family IID component
JW297_RS14565	COG3715	PTS system
JW297_RS14570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW297_RS14570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS14575	COG1760	l-serine dehydratase
JW297_RS14580	COG0494	nUDIX hydrolase
JW297_RS14605	COG1528	Iron-storage protein
JW297_RS14615	COG1276	copper resistance
JW297_RS14625	COG1956	GAF domain-containing protein
JW297_RS14630	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JW297_RS14640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JW297_RS14645	COG3189	MarR family transcriptional regulator
JW297_RS14650	COG0113	porphobilinogen synthase activity
JW297_RS14675	COG0589	response to stress
JW297_RS14700	COG2966	Psort location CytoplasmicMembrane, score
JW297_RS14705	COG3610	response to peptide
JW297_RS14715	COG2356	endonuclease I
JW297_RS14720	COG1702	phosphate starvation-inducible protein PhoH
JW297_RS14725	COG2375	cellular response to nickel ion
JW297_RS14735	COG1294	oxidase, subunit
JW297_RS14740	COG1271	oxidase subunit
JW297_RS14745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW297_RS14760	COG1280	lysine exporter protein (LysE YggA)
JW297_RS14775	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW297_RS14780	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW297_RS14785	COG1129	ABC transporter
JW297_RS14795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW297_RS14800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JW297_RS14820	COG0012	GTP binding
JW297_RS14825	COG0193	aminoacyl-tRNA hydrolase activity
JW297_RS14835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JW297_RS14840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JW297_RS14845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JW297_RS14850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JW297_RS14855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JW297_RS14870	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JW297_RS14875	COG1242	4 iron, 4 sulfur cluster binding
JW297_RS14885	COG0659	secondary active sulfate transmembrane transporter activity
JW297_RS14895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JW297_RS14900	COG3381	protein complex oligomerization
JW297_RS14905	COG2851	Citrate transporter
JW297_RS14915	COG0477	Major facilitator Superfamily
JW297_RS14920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW297_RS14935	COG0018	arginyl-trna synthetase
JW297_RS14940	COG3102	Protein conserved in bacteria
JW297_RS14945	COG3142	Participates in the control of copper homeostasis
JW297_RS14955	COG0500	methyltransferase
JW297_RS14965	COG3788	relative of glutathione S-transferase, MAPEG superfamily
JW297_RS14970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JW297_RS14975	COG0494	nUDIX hydrolase
JW297_RS14980	COG0217	transcriptional regulatory protein
JW297_RS14985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JW297_RS14990	COG0632	four-way junction helicase activity
JW297_RS14995	COG2255	four-way junction helicase activity
JW297_RS15005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JW297_RS15010	COG1121	(ABC) transporter
JW297_RS15015	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JW297_RS15020	COG0739	heme binding
JW297_RS15025	COG1560	Kdo2-lipid A biosynthetic process
JW297_RS15030	COG0469	pyruvate kinase activity
JW297_RS15035	COG1737	Transcriptional regulator
JW297_RS15040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JW297_RS15045	COG2076	Multidrug Resistance protein
JW297_RS15050	COG2076	Multidrug Resistance protein
JW297_RS15055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS15060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JW297_RS15065	COG1957	nucleoside hydrolase
JW297_RS15070	COG0745	RESPONSE REGULATOR receiver
JW297_RS15075	COG2205	protein histidine kinase activity
JW297_RS15110	COG1830	Aldolase
JW297_RS15120	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW297_RS15125	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW297_RS15135	COG2390	Transcriptional regulator
JW297_RS15140	COG1070	Carbohydrate kinase
JW297_RS15145	COG0251	oxidation-reduction process
JW297_RS15150	COG1199	ATP-dependent helicase activity
JW297_RS15160	COG3065	identical protein binding
JW297_RS15165	COG0318	PFAM AMP-dependent synthetase and ligase
JW297_RS15170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JW297_RS15175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JW297_RS15180	COG2894	cell division
JW297_RS15185	COG0850	regulation of cytokinetic process
JW297_RS15190	COG3100	YcgL domain-containing protein
JW297_RS15200	COG0179	Fumarylacetoacetate (FAA) hydrolase
JW297_RS15205	COG2983	Belongs to the UPF0260 family
JW297_RS15215	COG2226	methyltransferase
JW297_RS15225	COG1120	ATPase activity
JW297_RS15230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW297_RS15280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JW297_RS15285	COG2911	Protein conserved in bacteria
JW297_RS15295	COG3784	Protein of unknown function (DUF1318)
JW297_RS15305	COG1643	Atp-dependent helicase
JW297_RS15310	COG0531	amino acid
JW297_RS15320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JW297_RS15325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JW297_RS15335	COG0589	response to stress
JW297_RS15345	COG3321	synthase
JW297_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
JW297_RS15345	COG0604	alcohol dehydrogenase
JW297_RS15350	COG1695	Transcriptional regulator
JW297_RS15360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JW297_RS15365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS15365	COG1263	PTS System
JW297_RS15370	COG1609	Transcriptional regulator
JW297_RS15390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JW297_RS15420	COG0697	spore germination
JW297_RS15445	COG2850	peptidyl-arginine hydroxylation
JW297_RS15450	COG4628	conserved protein (DUF2132)
JW297_RS15455	COG2897	thiosulfate sulfurtransferase activity
JW297_RS15460	COG2391	methyltransferase activity
JW297_RS15465	COG4771	TonB-dependent receptor
JW297_RS15470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JW297_RS15475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW297_RS15480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JW297_RS15485	COG1902	pentaerythritol trinitrate reductase activity
JW297_RS15490	COG1309	transcriptional regulator
JW297_RS15495	COG0443	Heat shock 70 kDa protein
JW297_RS15510	COG0402	S-adenosylhomocysteine deaminase activity
JW297_RS15515	COG4807	Protein conserved in bacteria
JW297_RS15560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JW297_RS15565	COG1671	Belongs to the UPF0178 family
JW297_RS15580	COG0488	(ABC) transporter
JW297_RS15590	COG2076	Multidrug Resistance protein
JW297_RS15605	COG0697	spore germination
JW297_RS15620	COG0494	nUDIX hydrolase
JW297_RS15625	COG0456	acetyltransferase
JW297_RS15625	COG1846	Transcriptional regulator
JW297_RS15630	COG0583	DNA-binding transcription factor activity
JW297_RS15635	COG0814	amino acid
JW297_RS15640	COG0626	cystathionine gamma-synthase activity
JW297_RS15670	COG0590	tRNA wobble adenosine to inosine editing
JW297_RS15675	COG0583	DNA-binding transcription factor activity
JW297_RS15690	COG0477	Major facilitator Superfamily
JW297_RS15710	COG2814	Major facilitator Superfamily
JW297_RS15720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JW297_RS15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW297_RS15795	COG0789	Transcriptional regulator
JW297_RS15845	COG0488	(ABC) transporter
JW297_RS15855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JW297_RS15855	COG2169	Transcriptional regulator
JW297_RS15860	COG3145	DNA-N1-methyladenine dioxygenase activity
JW297_RS15880	COG2079	MmgE PrpD family protein
JW297_RS15890	COG4221	oxidoreductase activity
JW297_RS15905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JW297_RS15910	COG1940	carbohydrate kinase activity
JW297_RS15920	COG0583	DNA-binding transcription factor activity
JW297_RS15925	COG2814	Major facilitator Superfamily
JW297_RS15940	COG0114	fumarate hydratase activity
JW297_RS15945	COG1482	cell wall glycoprotein biosynthetic process
JW297_RS15950	COG5339	Protein conserved in bacteria
JW297_RS15955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JW297_RS15960	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JW297_RS15965	COG0385	Bile acid
JW297_RS15970	COG0673	inositol 2-dehydrogenase activity
JW297_RS15975	COG4657	Part of a membrane complex involved in electron transport
JW297_RS15985	COG4656	Part of a membrane complex involved in electron transport
JW297_RS15995	COG4659	FMN binding
JW297_RS16005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JW297_RS16010	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JW297_RS16020	COG0023	Translation Initiation Factor
JW297_RS16025	COG0284	orotidine-5'-phosphate decarboxylase activity
JW297_RS16030	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JW297_RS16035	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JW297_RS16040	COG0671	phosphoesterase, PA-phosphatase related
JW297_RS16045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JW297_RS16060	COG0583	DNA-binding transcription factor activity
JW297_RS16075	COG0616	signal peptide processing
JW297_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
JW297_RS16095	COG0009	L-threonylcarbamoyladenylate synthase
JW297_RS16110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JW297_RS16110	COG0512	Glutamine amidotransferase of anthranilate synthase
JW297_RS16115	COG0512	Glutamine amidotransferase of anthranilate synthase
JW297_RS16115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JW297_RS16120	COG0135	phosphoribosylanthranilate isomerase activity
JW297_RS16120	COG0134	indole-3-glycerol-phosphate synthase activity
JW297_RS16125	COG0133	tryptophan synthase activity
JW297_RS16130	COG0159	tryptophan synthase activity
JW297_RS16140	COG3047	cAMP biosynthetic process
JW297_RS16155	COG3111	PFAM Bacterial OB fold (BOF) protein
JW297_RS16165	COG0642	Histidine kinase
JW297_RS16175	COG2917	probably involved in intracellular septation
JW297_RS16185	COG0513	Belongs to the DEAD box helicase family
JW297_RS16195	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JW297_RS16205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JW297_RS16210	COG3099	Belongs to the UPF0263 family
JW297_RS16235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW297_RS16240	COG0601	transmembrane transport
JW297_RS16260	COG4166	transmembrane transport
JW297_RS16265	COG0747	negative chemotaxis
JW297_RS16270	COG0601	transmembrane transport
JW297_RS16275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW297_RS16280	COG0444	Belongs to the ABC transporter superfamily
JW297_RS16285	COG4608	Belongs to the ABC transporter superfamily
JW297_RS16290	COG2095	MarC family integral membrane protein
JW297_RS16295	COG1012	belongs to the aldehyde dehydrogenase family
JW297_RS16295	COG1454	alcohol dehydrogenase
JW297_RS16300	COG1435	thymidine kinase activity
JW297_RS16320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JW297_RS16325	COG0745	RESPONSE REGULATOR receiver
JW297_RS16330	COG3012	SEC-C Motif Domain Protein
JW297_RS16335	COG0788	formyltetrahydrofolate deformylase activity
JW297_RS16350	COG0708	Exodeoxyribonuclease III
JW297_RS16355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JW297_RS16365	COG0778	Nitroreductase
JW297_RS16370	COG0616	signal peptide processing
JW297_RS16375	COG0252	asparaginase activity
JW297_RS16380	COG1335	isochorismatase
JW297_RS16385	COG3139	Protein of unknown function (DUF1315)
JW297_RS16390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW297_RS16395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JW297_RS16410	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
JW297_RS16415	COG3713	MltA-interacting MipA family protein
JW297_RS16420	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JW297_RS16425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JW297_RS16430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JW297_RS16440	COG2186	Transcriptional regulator
JW297_RS16445	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JW297_RS16450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JW297_RS16455	COG3042	response to heat
JW297_RS16475	COG0488	(ABC) transporter
JW297_RS16505	COG1396	sequence-specific DNA binding
JW297_RS16510	COG1396	sequence-specific DNA binding
JW297_RS16520	COG0598	Magnesium transport protein CorA
JW297_RS16525	COG4166	transmembrane transport
JW297_RS16540	COG3768	UPF0283 membrane protein
JW297_RS16545	COG3106	COG3106 Predicted ATPase
JW297_RS16555	COG1983	PspC domain protein
JW297_RS16565	COG1842	Phage shock protein A
JW297_RS16570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JW297_RS16575	COG4166	transmembrane transport
JW297_RS16585	COG4171	peptide transport system, permease
JW297_RS16595	COG4172	Belongs to the ABC transporter superfamily
JW297_RS16630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JW297_RS16635	COG3133	Outer membrane lipoprotein
JW297_RS16640	COG1846	Transcriptional regulator
JW297_RS16645	COG3313	Fe-S protein
JW297_RS16650	COG0346	lactoylglutathione lyase activity
JW297_RS16665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JW297_RS16670	COG1280	lysine exporter protein (LysE YggA)
JW297_RS16685	COG3122	Protein conserved in bacteria
JW297_RS16705	COG1609	Transcriptional regulator
JW297_RS16710	COG0583	DNA-binding transcription factor activity
JW297_RS16715	COG2814	Major facilitator Superfamily
JW297_RS16720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JW297_RS16725	COG0307	riboflavin synthase, alpha
JW297_RS16730	COG0534	Mate efflux family protein
JW297_RS16755	COG1376	ErfK ybiS ycfS ynhG family protein
JW297_RS16755	COG1388	LysM domain
JW297_RS16760	COG2166	iron-sulfur cluster assembly
JW297_RS16765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JW297_RS16770	COG0719	Fe-S assembly protein
JW297_RS16775	COG0396	ATPase activity
JW297_RS16780	COG0719	Fe-S assembly protein
JW297_RS16785	COG0316	Belongs to the HesB IscA family
JW297_RS16790	COG2050	protein possibly involved in aromatic compounds catabolism
JW297_RS16795	COG0277	FAD linked oxidase domain protein
JW297_RS16795	COG0247	lactate metabolic process
JW297_RS16800	COG0628	permease
JW297_RS16805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JW297_RS16805	COG0574	Belongs to the PEP-utilizing enzyme family
JW297_RS16810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JW297_RS16815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JW297_RS16820	COG4256	Hemin uptake protein
JW297_RS16825	COG3720	iron ion transport
JW297_RS16830	COG4558	Periplasmic binding protein
JW297_RS16835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW297_RS16840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JW297_RS16850	COG2207	Transcriptional regulator
JW297_RS16865	COG0791	NLP P60 protein
JW297_RS16870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JW297_RS16875	COG2076	Multidrug Resistance protein
JW297_RS16880	COG2076	Multidrug Resistance protein
JW297_RS16885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JW297_RS16890	COG0726	polysaccharide deacetylase
JW297_RS16895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JW297_RS16895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JW297_RS16900	COG0463	Glycosyl transferase, family 2
JW297_RS16905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JW297_RS16910	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JW297_RS16915	COG4139	cobalamin transport
JW297_RS16920	COG0776	regulation of translation
JW297_RS16925	COG0072	phenylalanine-tRNA ligase activity
JW297_RS16925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW297_RS16930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JW297_RS16945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JW297_RS16955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JW297_RS16960	COG2194	sulfuric ester hydrolase activity
JW297_RS16970	COG0803	Belongs to the bacterial solute-binding protein 9 family
JW297_RS16975	COG1121	(ABC) transporter
JW297_RS16980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JW297_RS16985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JW297_RS16990	COG3001	Fructosamine kinase
JW297_RS17000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JW297_RS17005	COG1988	membrane-bound metal-dependent
JW297_RS17010	COG1823	symporter activity
JW297_RS17015	COG0501	Belongs to the peptidase M48B family
JW297_RS17020	COG0346	lactoylglutathione lyase activity
JW297_RS17025	COG0281	malic enzyme
JW297_RS17025	COG0280	phosphate acetyltransferase
JW297_RS17030	COG2197	response regulator
JW297_RS17040	COG1393	Belongs to the ArsC family
JW297_RS17050	COG1876	peptidase activity
JW297_RS17055	COG2832	Protein of unknown function (DUF454)
JW297_RS17075	COG2707	UPF0756 membrane protein
JW297_RS17080	COG2321	neutral zinc metallopeptidase
JW297_RS17085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JW297_RS17090	COG1349	DNA-binding transcription factor activity
JW297_RS17095	COG0483	inositol monophosphate 1-phosphatase activity
JW297_RS17100	COG2223	nitrite transmembrane transporter activity
JW297_RS17105	COG1216	Glycosyl transferase, family 2
JW297_RS17110	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JW297_RS17120	COG2716	regulation of RNA biosynthetic process
JW297_RS17125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JW297_RS17135	COG0628	permease
JW297_RS17140	COG4783	chaperone-mediated protein folding
JW297_RS17145	COG1393	Belongs to the ArsC family
JW297_RS17165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JW297_RS17170	COG2267	carboxylic ester hydrolase activity
JW297_RS17175	COG2453	phosphatase
JW297_RS17175	COG0671	phosphoesterase, PA-phosphatase related
JW297_RS17185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JW297_RS17190	COG2233	PERMEase
JW297_RS17195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JW297_RS17200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JW297_RS17205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JW297_RS17215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW297_RS17220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JW297_RS17225	COG0248	Ppx GppA phosphatase
JW297_RS17230	COG2239	Acts as a magnesium transporter
JW297_RS17255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW297_RS17260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JW297_RS17265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JW297_RS17270	COG2205	protein histidine kinase activity
JW297_RS17275	COG0745	RESPONSE REGULATOR receiver
JW297_RS17285	COG0826	peptidase U32
JW297_RS17290	COG1597	lipid kinase activity
JW297_RS17295	COG1830	Aldolase
JW297_RS17300	COG1187	pseudouridine synthase activity
JW297_RS17305	COG0351	phosphomethylpyrimidine kinase
JW297_RS17320	COG1113	amino acid transport
JW297_RS17330	COG2207	Transcriptional regulator
JW297_RS17335	COG0561	phosphatase activity
JW297_RS17340	COG1114	Component of the transport system for branched-chain amino acids
JW297_RS17345	COG3023	N-Acetylmuramoyl-L-alanine amidase
JW297_RS17360	COG1115	amino acid carrier protein
JW297_RS17380	COG1584	GPR1 FUN34 yaaH family protein
JW297_RS17395	COG0318	PFAM AMP-dependent synthetase and ligase
JW297_RS17400	COG1441	menaquinone biosynthetic process
JW297_RS17410	COG0596	Alpha beta hydrolase
JW297_RS17415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JW297_RS17420	COG1169	isochorismate synthase
JW297_RS17435	COG1007	ATP synthesis coupled electron transport
JW297_RS17440	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW297_RS17445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JW297_RS17450	COG0713	ATP synthesis coupled electron transport
JW297_RS17455	COG0839	Belongs to the complex I subunit 6 family
JW297_RS17460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW297_RS17465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JW297_RS17485	COG0649	NAD binding
JW297_RS17485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW297_RS17495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JW297_RS17500	COG0583	DNA-binding transcription factor activity
JW297_RS17505	COG0436	Aminotransferase
JW297_RS17510	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JW297_RS17515	COG0490	domain, Protein
JW297_RS17515	COG0471	metal ion transport
JW297_RS17520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JW297_RS17525	COG3013	Belongs to the UPF0304 family
JW297_RS17530	COG3092	negative regulation of chromosome organization
JW297_RS17535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JW297_RS17540	COG0280	phosphate acetyltransferase
JW297_RS17540	COG0857	belongs to the CobB CobQ family
JW297_RS17555	COG1090	epimerase
JW297_RS17560	COG0163	prenyltransferase activity
JW297_RS17565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JW297_RS17570	COG1286	toxin biosynthetic process
JW297_RS17575	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JW297_RS17580	COG0285	dihydrofolate synthase activity
JW297_RS17585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JW297_RS17590	COG0586	Pfam SNARE associated Golgi protein
JW297_RS17595	COG0101	tRNA pseudouridine synthase activity
JW297_RS17600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JW297_RS17605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JW297_RS17615	COG0697	spore germination
JW297_RS17625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JW297_RS17630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JW297_RS17630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JW297_RS17655	COG3101	peptidyl-lysine hydroxylation
JW297_RS17660	COG0730	response to heat
JW297_RS17665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JW297_RS17675	COG2840	Smr protein MutS2
JW297_RS17680	COG2062	phosphohistidine phosphatase, SixA
JW297_RS17685	COG1250	3-hydroxyacyl-CoA dehydrogenase
JW297_RS17685	COG1024	Enoyl-CoA hydratase
JW297_RS17690	COG0183	Belongs to the thiolase family
JW297_RS17695	COG3691	Protein conserved in bacteria
JW297_RS17700	COG2067	long-chain fatty acid transport protein
JW297_RS17710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JW297_RS17715	COG3048	D-serine ammonia-lyase activity
JW297_RS17720	COG2610	gluconate transmembrane transporter activity
JW297_RS17725	COG0583	DNA-binding transcription factor activity
JW297_RS17750	COG3772	lysozyme
JW297_RS17780	COG1464	Belongs to the NlpA lipoprotein family
JW297_RS17810	COG3422	double-strand break repair
JW297_RS17820	COG2841	Protein conserved in bacteria
JW297_RS17845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JW297_RS17850	COG2315	Protein conserved in bacteria
JW297_RS17855	COG1396	sequence-specific DNA binding
JW297_RS17860	COG0702	epimerase
JW297_RS17865	COG1733	regulation of RNA biosynthetic process
JW297_RS17870	COG0582	viral genome integration into host DNA
JW297_RS17895	COG0538	isocitrate dehydrogenase activity
JW297_RS18065	COG3772	lysozyme
JW297_RS18090	COG0589	response to stress
JW297_RS18100	COG1403	HNH endonuclease
JW297_RS18165	COG0582	viral genome integration into host DNA
JW297_RS18180	COG0538	isocitrate dehydrogenase activity
JW297_RS18185	COG1187	pseudouridine synthase activity
JW297_RS18195	COG0482	sulfurtransferase activity
JW297_RS18200	COG2915	High frequency lysogenization protein hflD homolog
JW297_RS18205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JW297_RS18210	COG0745	RESPONSE REGULATOR receiver
JW297_RS18220	COG2850	peptidyl-arginine hydroxylation
JW297_RS18230	COG3188	usher protein
JW297_RS18235	COG3121	Chaperone
JW297_RS18255	COG4591	ABC-type transport system involved in lipoprotein release permease component
JW297_RS18260	COG1136	(ABC) transporter
JW297_RS18265	COG4591	ABC-type transport system involved in lipoprotein release permease component
JW297_RS18270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JW297_RS18275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JW297_RS18290	COG1252	NADH dehydrogenase
JW297_RS18295	COG3150	esterase
JW297_RS18300	COG1472	Belongs to the glycosyl hydrolase 3 family
JW297_RS18310	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
JW297_RS18315	COG0537	adenosine 5'-monophosphoramidase activity
JW297_RS18320	COG0084	hydrolase, TatD family'
JW297_RS18325	COG0470	DNA polymerase III
JW297_RS18335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JW297_RS18340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JW297_RS18345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JW297_RS18350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JW297_RS18360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JW297_RS18365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JW297_RS18370	COG0416	fatty acid biosynthetic process
JW297_RS18375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JW297_RS18380	COG1399	metal-binding, possibly nucleic acid-binding protein
JW297_RS18385	COG0424	maF-like protein
JW297_RS18395	COG0564	pseudouridine synthase activity
JW297_RS18400	COG1530	ribonuclease E activity
JW297_RS18405	COG2926	Belongs to the UPF0265 family
JW297_RS18410	COG2925	Exonuclease
JW297_RS18420	COG0277	FAD linked oxidase domain protein
JW297_RS18430	COG0531	amino acid
JW297_RS18435	COG4771	TonB-dependent receptor
JW297_RS18440	COG1120	ATPase activity
JW297_RS18445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW297_RS18455	COG0833	amino acid
JW297_RS18460	COG0583	DNA-binding transcription factor activity
JW297_RS18465	COG2855	membrane
JW297_RS18470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JW297_RS18475	COG1105	Belongs to the carbohydrate kinase PfkB family
JW297_RS18480	COG0494	nUDIX hydrolase
JW297_RS18485	COG0814	amino acid
JW297_RS18490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JW297_RS18505	COG0671	phosphoesterase, PA-phosphatase related
JW297_RS18510	COG0791	NLP P60 protein
JW297_RS18520	COG2814	Major facilitator Superfamily
JW297_RS18525	COG1187	pseudouridine synthase activity
JW297_RS18530	COG1061	Type III restriction enzyme res subunit
JW297_RS18535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JW297_RS18540	COG3081	Nucleoid-associated protein
JW297_RS18545	COG3082	Protein of unknown function (DUF1414)
JW297_RS18550	COG3083	sulfuric ester hydrolase activity
JW297_RS18560	COG1278	Cold shock
JW297_RS18565	COG3969	phosphoadenosine phosphosulfate
JW297_RS18570	COG1475	DNA binding
JW297_RS18580	COG0730	response to heat
JW297_RS18590	COG0586	Pfam SNARE associated Golgi protein
JW297_RS18600	COG1278	Cold shock
JW297_RS18620	COG2814	Major facilitator Superfamily
JW297_RS18630	COG1032	radical SAM domain protein
JW297_RS18650	COG1032	radical SAM domain protein
JW297_RS18655	COG1032	radical SAM domain protein
JW297_RS18860	COG2369	cell adhesion
JW297_RS18895	COG3772	lysozyme
JW297_RS18905	COG3272	Protein of unknown function (DUF1722)
JW297_RS18935	COG0305	Participates in initiation and elongation during chromosome replication
JW297_RS18945	COG1802	Transcriptional regulator
JW297_RS18945	COG4626	Terminase
JW297_RS19035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JW297_RS19040	COG0322	excinuclease ABC activity
JW297_RS19045	COG2197	response regulator
JW297_RS19050	COG0778	Nitroreductase
JW297_RS19060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JW297_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
JW297_RS19070	COG2837	iron assimilation
JW297_RS19075	COG2822	iron ion transport
JW297_RS19085	COG4633	Protein conserved in bacteria
JW297_RS19180	COG3530	Putative quorum-sensing-regulated virulence factor
JW297_RS19185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JW297_RS19190	COG3115	cell septum assembly
JW297_RS19205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW297_RS19210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JW297_RS19240	COG3135	benzoate transporter
JW297_RS19245	COG1396	sequence-specific DNA binding
JW297_RS19275	COG1309	transcriptional regulator
JW297_RS19605	COG0582	viral genome integration into host DNA
JW297_RS19630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JW297_RS19635	COG0813	purine-nucleoside phosphorylase activity
JW297_RS19660	COG4771	TonB-dependent receptor
JW297_RS19665	COG1609	Transcriptional regulator
JW297_RS19670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW297_RS19675	COG2017	converts alpha-aldose to the beta-anomer
JW297_RS19680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JW297_RS19685	COG1085	galactose-1-phosphate uridylyltransferase
JW297_RS19690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JW297_RS19695	COG1609	Transcriptional regulator
JW297_RS19700	COG3250	beta-galactosidase activity
JW297_RS19705	COG2731	YhcH YjgK YiaL family protein
JW297_RS19735	COG0640	Transcriptional regulator
JW297_RS19785	COG5001	Diguanylate cyclase
JW297_RS19785	COG3300	MHYT domain
JW297_RS19875	COG0531	amino acid
JW297_RS19885	COG2233	PERMEase
JW297_RS19905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JW297_RS19925	COG2841	Protein conserved in bacteria
JW297_RS19945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW297_RS19955	COG3842	ATPase activity
JW297_RS19960	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JW297_RS19965	COG0725	ABC transporter, periplasmic molybdate-binding protein
JW297_RS19985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
JW297_RS20000	COG0583	DNA-binding transcription factor activity
JW297_RS20035	COG1309	transcriptional regulator
JW297_RS20040	COG0531	amino acid
JW297_RS20045	COG1982	Orn Lys Arg decarboxylase major
JW297_RS20060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JW297_RS20070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JW297_RS20075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JW297_RS20085	COG0716	FMN binding
JW297_RS20100	COG0354	folic acid binding
JW297_RS20110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JW297_RS20110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JW297_RS20115	COG0509	glycine decarboxylation via glycine cleavage system
JW297_RS20120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JW297_RS20125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JW297_RS20130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JW297_RS20135	COG0006	proline dipeptidase activity
JW297_RS20140	COG3079	Belongs to the UPF0149 family
JW297_RS20155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JW297_RS20160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JW297_RS20165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JW297_RS20170	COG0583	DNA-binding transcription factor activity
JW297_RS20180	COG1279	arginine transmembrane transporter activity
JW297_RS20190	COG0668	transmembrane transport
JW297_RS20195	COG3112	Uncharacterised protein family (UPF0231)
JW297_RS20200	COG1049	propionate catabolic process, 2-methylcitrate cycle
JW297_RS20205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW297_RS20210	COG0508	dehydrogenase complex catalyzes the overall conversion of
JW297_RS20215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JW297_RS20225	COG3023	N-Acetylmuramoyl-L-alanine amidase
JW297_RS20230	COG4969	Belongs to the N-Me-Phe pilin family
JW297_RS20235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JW297_RS20245	COG0237	dephospho-CoA kinase activity
JW297_RS20250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JW297_RS20260	COG0494	nUDIX hydrolase
JW297_RS20265	COG0653	protein targeting
JW297_RS20280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JW297_RS20285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JW297_RS20290	COG0849	cell division
JW297_RS20295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JW297_RS20305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JW297_RS20310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JW297_RS20315	COG0772	Belongs to the SEDS family
JW297_RS20325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JW297_RS20330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JW297_RS20335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JW297_RS20340	COG0768	penicillin binding
JW297_RS20345	COG3116	cell division
JW297_RS20350	COG0275	rRNA processing
JW297_RS20355	COG2001	Belongs to the MraZ family
JW297_RS20370	COG0028	Belongs to the TPP enzyme family
JW297_RS20375	COG1022	Amp-dependent synthetase and ligase
JW297_RS20385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JW297_RS20390	COG0473	3-isopropylmalate dehydrogenase activity
JW297_RS20395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JW297_RS20405	COG4533	DNA binding
JW297_RS20410	COG3066	DNA modification
JW297_RS20430	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JW297_RS20445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW297_RS20460	COG0583	DNA-binding transcription factor activity
JW297_RS20480	COG1129	ABC transporter
JW297_RS20490	COG0010	Belongs to the arginase family
JW297_RS20495	COG1166	arginine decarboxylase activity
JW297_RS20500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JW297_RS20515	COG0640	Transcriptional regulator
JW297_RS20525	COG2239	Acts as a magnesium transporter
JW297_RS20535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JW297_RS20540	COG1151	hydroxylamine reductase activity
JW297_RS20545	COG4772	TonB-dependent receptor
JW297_RS20555	COG1115	amino acid carrier protein
JW297_RS20575	COG2814	Major facilitator Superfamily
JW297_RS20580	COG1566	PFAM secretion protein HlyD family protein
JW297_RS20590	COG2353	YceI-like domain
JW297_RS20595	COG3038	cytochrome b561
JW297_RS20630	COG2390	Transcriptional regulator
JW297_RS20635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JW297_RS20640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JW297_RS20645	COG0842	Transport permease protein
JW297_RS20645	COG1129	ABC transporter
JW297_RS20650	COG0842	Transport permease protein
JW297_RS20655	COG1609	Transcriptional regulator
JW297_RS20670	COG1070	Carbohydrate kinase
JW297_RS20675	COG1129	ABC transporter
JW297_RS20680	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW297_RS20685	COG1879	ABC-type sugar transport system periplasmic component
JW297_RS20700	COG3961	Belongs to the TPP enzyme family
JW297_RS20715	COG1349	DNA-binding transcription factor activity
JW297_RS20725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS20735	COG3716	PTS system mannose fructose sorbose family IID component
JW297_RS20740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW297_RS20745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JW297_RS20750	COG2222	sugar isomerase
JW297_RS20760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW297_RS20760	COG1263	PTS System
JW297_RS20770	COG2233	PERMEase
JW297_RS20775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW297_RS20775	COG0493	'glutamate synthase
JW297_RS20780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JW297_RS20785	COG2313	pseudouridylate synthase activity
JW297_RS20790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW297_RS20790	COG1522	sequence-specific DNA binding
JW297_RS20795	COG3443	Belongs to the bacterial solute-binding protein 9 family
JW297_RS20800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JW297_RS20805	COG0254	rRNA binding
JW297_RS20810	COG0754	glutathionylspermidine amidase activity
JW297_RS20815	COG2233	PERMEase
JW297_RS20820	COG1064	alcohol dehydrogenase
JW297_RS20855	COG0604	alcohol dehydrogenase
JW297_RS20860	COG1309	transcriptional regulator
JW297_RS20870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JW297_RS20885	COG0640	Transcriptional regulator